Christopher J. Schofield
#68,842
Most Influential Person Now
British chemist
Christopher J. Schofield's AcademicInfluence.com Rankings
Christopher J. Schofieldchemistry Degrees
Chemistry
#1354
World Rank
#2048
Historical Rank
Organic Chemistry
#194
World Rank
#245
Historical Rank
Download Badge
Chemistry
Why Is Christopher J. Schofield Influential?
(Suggest an Edit or Addition)According to Wikipedia, Christopher Joseph Schofield is a Professor of Chemistry at the University of Oxford and a Fellow of the Royal Society. Chris Schofield is a professor of organic chemistry at the University of Oxford, Department of Chemistry and a Fellow of Hertford College. Schofield studied functional, structural and mechanistic understanding of enzymes that employ oxygen and 2-oxoglutarate as a co-substrate. His work has opened up new possibilities in antibiotic research, oxygen sensing, and gene regulation.
Christopher J. Schofield's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation (2001) (4708)
- C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation (2001) (3193)
- Oxygen sensing by HIF hydroxylases (2004) (1916)
- The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase (2007) (1375)
- The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases (2011) (851)
- A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response (2012) (783)
- Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family* (2002) (681)
- Expanding chemical biology of 2-oxoglutarate oxygenases. (2008) (462)
- Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL (2002) (454)
- Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins. (2006) (389)
- Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes (1995) (389)
- Jmjd6 Catalyses Lysyl-Hydroxylation of U2AF65, a Protein Associated with RNA Splicing (2009) (377)
- Structure of Factor-inhibiting Hypoxia-inducible Factor (HIF) Reveals Mechanism of Oxidative Modification of HIF-1α* (2003) (344)
- Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes. (1999) (333)
- A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene (2009) (318)
- Signalling hypoxia by HIF hydroxylases. (2005) (314)
- Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2). (2006) (314)
- Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity (2007) (307)
- Structure of a cephalosporin synthase (1998) (297)
- Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha. (2008) (279)
- Structure and mechanism of anthocyanidin synthase from Arabidopsis thaliana. (2002) (275)
- Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH) (2006) (271)
- 2-Oxoglutarate-Dependent Oxygenases. (2018) (260)
- Methods for converting cysteine to dehydroalanine on peptides and proteins (2011) (255)
- Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases. (2011) (237)
- Structural studies on human 2-oxoglutarate dependent oxygenases. (2010) (235)
- Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase (2000) (234)
- Structure of isopenicillinN synthase complexed with substrate and the mechanism ofpenicillin formation (1997) (231)
- Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains (2014) (222)
- Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases. (2008) (218)
- The hypoxia‐inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens (2011) (215)
- Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. (2002) (213)
- Asparaginyl Hydroxylation of the Notch Ankyrin Repeat Domain by Factor Inhibiting Hypoxia-inducible Factor* (2007) (206)
- Structural and Mechanistic Studies on the Inhibition of the Hypoxia-inducible Transcription Factor Hydroxylases by Tricarboxylic Acid Cycle Intermediates* (2007) (204)
- Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay. (2007) (200)
- Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases. (2009) (198)
- Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors (2010) (198)
- Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803. (2002) (197)
- Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates (2016) (192)
- Inhibition of 2-oxoglutarate dependent oxygenases. (2011) (191)
- Mechanistic Studies on Three 2-Oxoglutarate-dependent Oxygenases of Flavonoid Biosynthesis (2004) (187)
- Targeting histone lysine demethylases — Progress, challenges, and the future (2014) (167)
- Inhibition of 2‐Oxoglutarate Dependent Oxygenases (2011) (162)
- Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases (2016) (160)
- Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases. (2012) (158)
- Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions. (2012) (158)
- Human UTY(KDM6C) Is a Male-specific Nϵ-Methyl Lysyl Demethylase* (2014) (155)
- PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase. (2010) (154)
- Conversion of cysteine into dehydroalanine enables access to synthetic histones bearing diverse post-translational modifications. (2012) (153)
- Recent Progress in Histone Demethylase Inhibitors. (2016) (152)
- Refsum's disease: a peroxisomal disorder affecting phytanic acid α‐oxidation (2002) (148)
- The HIF pathway as a therapeutic target. (2004) (146)
- The enzymes of β-lactam biosynthesis. (2013) (146)
- Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches† (2010) (143)
- 2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase. (2003) (143)
- Epidithiodiketopiperazines Block the Interaction between Hypoxia-inducible Factor-1α (HIF-1α) and p300 by a Zinc Ejection Mechanism* (2009) (142)
- Differential Sensitivity of Hypoxia Inducible Factor Hydroxylation Sites to Hypoxia and Hydroxylase Inhibitors* (2011) (142)
- Mechanisms of human histone and nucleic acid demethylases. (2012) (141)
- Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair. (2011) (140)
- Chemistry and biosynthesis of clavulanic acid and other clavams. (1997) (138)
- Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation (2014) (137)
- Structural and Evolutionary Basis for the Dual Substrate Selectivity of Human KDM4 Histone Demethylase Family* (2011) (132)
- 5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation. (2013) (131)
- Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. (2012) (131)
- Crystal structure of a clavaminate synthase–Fe(II)–2‐oxoglutarate–substrate–NO complex: evidence for metal centred rearrangements (2002) (122)
- Selective inhibition of factor inhibiting hypoxia-inducible factor. (2005) (122)
- The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity (2012) (120)
- Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation. (1997) (120)
- Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents. (2010) (119)
- Structures of Human ALKBH5 Demethylase Reveal a Unique Binding Mode for Specific Single-stranded N6-Methyladenosine RNA Demethylation* (2014) (116)
- Protein Hydroxylation Catalyzed by 2-Oxoglutarate-dependent Oxygenases* (2015) (114)
- Structural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols. (2008) (113)
- Expression of Idh1R132H in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis (2016) (113)
- Crystal structure and mechanistic implications of 1-aminocyclopropane-1-carboxylic acid oxidase--the ethylene-forming enzyme. (2004) (112)
- Structural basis for inhibition of the fat mass and obesity associated protein (FTO). (2013) (111)
- Pharmacological targeting of the HIF hydroxylases--A new field in medicine development. (2016) (110)
- Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers (2015) (109)
- Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. (2012) (109)
- Studies on the active site of deacetoxycephalosporin C synthase. (1999) (109)
- Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy (2014) (106)
- Human AlkB Homologue 5 Is a Nuclear 2-Oxoglutarate Dependent Oxygenase and a Direct Target of Hypoxia-Inducible Factor 1α (HIF-1α) (2011) (106)
- Inhibition of TEM-2 beta-lactamase from Escherichia coli by clavulanic acid: observation of intermediates by electrospray ionization mass spectrometry. (1996) (104)
- Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. (2013) (104)
- The use of dioxygen by HIF prolyl hydroxylase (PHD1). (2002) (103)
- Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition. (2014) (103)
- Mechanisms and structures of crotonase superfamily enzymes – How nature controls enolate and oxyanion reactivity (2008) (103)
- Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities. (2014) (102)
- Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models (2016) (101)
- Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate. (2005) (101)
- Thiomandelic acid, a broad spectrum inhibitor of zinc beta-lactamases: kinetic and spectroscopic studies. (2001) (99)
- DNA Modification under Mild Conditions by Suzuki–Miyaura Cross-Coupling for the Generation of Functional Probes** (2013) (99)
- Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases (2019) (98)
- Noninvasive Quantification of 2-Hydroxyglutarate in Human Gliomas with IDH1 and IDH2 Mutations. (2016) (97)
- Highly selective inhibition of histone demethylases by de novo macrocyclic peptides (2017) (97)
- OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation (2014) (96)
- X-ray snapshots of serine protease catalysis reveal a tetrahedral intermediate (2001) (96)
- The Selectivity and Inhibition of AlkB* (2003) (95)
- Optimal Translational Termination Requires C4 Lysyl Hydroxylation of eRF1 (2014) (94)
- Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1 (2017) (93)
- Kinetic and crystallographic studies on deacetoxycephalosporin C synthase (DAOCS). (2001) (90)
- Structure of proline 3-hydroxylase. Evolution of the family of 2-oxoglutarate dependent oxygenases. (2001) (89)
- Assay Platform for Clinically Relevant Metallo-β-lactamases (2013) (89)
- The road to avibactam: the first clinically useful non-β-lactam working somewhat like a β-lactam. (2016) (89)
- Oxidative degradation of bilirubin produces vasoactive compounds. (2000) (87)
- Metabolic adaptation to chronic hypoxia in cardiac mitochondria (2012) (87)
- Bisthiazolidines: A Substrate-Mimicking Scaffold as an Inhibitor of the NDM-1 Carbapenemase. (2015) (86)
- Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases (2016) (86)
- Cyclic Boronates Inhibit All Classes of β-Lactamases (2017) (85)
- Trifluoromethyl alcohol and ketone inhibitors of metallo-β-lactamases (1996) (85)
- Therapeutic manipulation of the HIF hydroxylases. (2010) (84)
- Metal-catalyzed oxidation and mutagenesis studies on the iron(II) binding site of 1-aminocyclopropane-1-carboxylate oxidase. (1997) (84)
- Oxygenase catalyzed 5-methylcytosine hydroxylation. (2009) (84)
- Ribosomal Oxygenases are Structurally Conserved from Prokaryotes to Humans (2014) (82)
- Crystal Structure of Carbapenem Synthase (CarC)* (2003) (82)
- The Mechanism of ACV Synthetase. (1997) (82)
- Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells (2017) (81)
- Purification and initial characterization of proline 4-hydroxylase from Streptomyces griseoviridus P8648: a 2-oxoacid, ferrous-dependent dioxygenase involved in etamycin biosynthesis. (1996) (81)
- The chemical biology of branched-chain lipid metabolism. (2003) (80)
- A miniaturized screen for inhibitors of Jumonji histone demethylases. (2010) (79)
- 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors (2016) (78)
- Structure-function relationships of human JmjC oxygenases-demethylases versus hydroxylases. (2016) (78)
- Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases (2014) (78)
- Evidence for the slow reaction of hypoxia‐inducible factor prolyl hydroxylase 2 with oxygen (2010) (78)
- Amino acid synthesis via ring opening of N-sulphonyl aziridine-2-carboxylate esters with organometallic reagents (1993) (76)
- Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6. (2010) (76)
- The human oxygen sensing machinery and its manipulation. (2008) (76)
- Identification of valid housekeeping genes for quantitative RT-PCR analysis of cardiosphere-derived cells preconditioned under hypoxia or with prolyl-4-hydroxylase inhibitors (2011) (75)
- The oxygenase Jmjd6--a case study in conflicting assignments. (2015) (75)
- Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity. (2004) (75)
- Inhibition of Histone Demethylases by 4‐Carboxy‐2,2′‐Bipyridyl Compounds (2011) (75)
- Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(II). (2009) (75)
- Analysis of Jmjd6 Cellular Localization and Testing for Its Involvement in Histone Demethylation (2010) (74)
- Structure of Human Phytanoyl-CoA 2-Hydroxylase Identifies Molecular Mechanisms of Refsum Disease* (2005) (74)
- Refsum's disease: a peroxisomal disorder affecting phytanic acid alpha-oxidation. (2002) (74)
- Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors. (2012) (73)
- Proteins of the penicillin biosynthesis pathway. (1997) (72)
- Purification and initial characterization of an enzyme with deacetoxycephalosporin C synthetase and hydroxylase activities. (1987) (71)
- Interaction of Avibactam with Class B Metallo-β-Lactamases (2016) (71)
- The Chemical Biology of Human Metallo-β-Lactamase Fold Proteins (2016) (70)
- Human SNM1A suppresses the DNA repair defects of yeast pso2 mutants. (2008) (70)
- Glyco- and peptidomimetics from three-component Joullié-Ugi coupling show selective antiviral activity. (2005) (69)
- Kinetic Rationale for Selectivity toward N- and C-terminal Oxygen-dependent Degradation Domain Substrates Mediated by a Loop Region of Hypoxia-Inducible Factor Prolyl Hydroxylases* (2008) (69)
- Allosteric Inhibition of the SARS‐CoV‐2 Main Protease: Insights from Mass Spectrometry Based Assays (2020) (69)
- Acyl coenzyme A: 6‐aminopenicillanic acid acyltransferase from Penicillium chrysogenum and Aspergillus nidulans (1990) (68)
- Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases. (2012) (68)
- Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains (2011) (68)
- Hydroxylation of methylated CpG dinucleotides reverses stabilisation of DNA duplexes by cytosine 5-methylation. (2011) (67)
- Structure-function analysis of phytanoyl-CoA 2-hydroxylase mutations causing Refsum's disease. (2001) (66)
- Identification of the KDM2/7 Histone Lysine Demethylase Subfamily Inhibitor and its Antiproliferative Activity (2013) (65)
- Studies on the catalytic domains of multiple JmjC oxygenases using peptide substrates (2014) (65)
- Emulsion PCR significantly improves nonequilibrium capillary electrophoresis of equilibrium mixtures-based aptamer selection: allowing for efficient and rapid selection of aptamer to unmodified ABH2 protein. (2015) (65)
- Stereospecific synthesis of dealanylalahopcin (1990) (65)
- Structural and mechanistic studies on γ-butyrobetaine hydroxylase. (2010) (65)
- A Code for RanGDP Binding in Ankyrin Repeats Defines a Nuclear Import Pathway (2014) (64)
- Asparagine and Aspartate Hydroxylation of the Cytoskeletal Ankyrin Family Is Catalyzed by Factor-inhibiting Hypoxia-inducible Factor* (2010) (64)
- Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses (2017) (64)
- Modulating the hypoxia-inducible factor signaling pathway: applications from cardiovascular disease to cancer. (2004) (63)
- Targeting Protein–Protein Interactions in the HIF System (2016) (63)
- Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility (2010) (63)
- PTP1B regulates non-mitochondrial oxygen consumption via RNF213 to promote tumour survival during hypoxia (2016) (63)
- Small-molecule-based inhibition of histone demethylation in cells assessed by quantitative mass spectrometry. (2010) (63)
- Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases* (2016) (63)
- Are anthocyanidins the immediate products of anthocyanidin synthase (2001) (62)
- Development of homogeneous luminescence assays for histone demethylase catalysis and binding. (2010) (62)
- Mechanistic insights into the inhibition of serine proteases by monocyclic lactams. (1999) (60)
- Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins (2007) (60)
- Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor* (2015) (60)
- X-ray absorption studies of the ferrous active site of isopenicillin N synthase and related model complexes. (1993) (59)
- Structural insights into how 5-hydroxymethylation influences transcription factor binding. (2014) (59)
- Monitoring Conformational Changes in the NDM-1 Metallo-β-lactamase by 19F NMR Spectroscopy** (2014) (59)
- Faculty Opinions recommendation of Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response. (2002) (58)
- Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases. (2003) (58)
- Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1). (2011) (57)
- How formaldehyde reacts with amino acids (2019) (57)
- A γ-lactam analogue of penems possessing antibacterial activity (1986) (57)
- Isolation and partial characterisation of ACV synthetase from Cephalosporium acremonium and Streptomyces clavuligerus. (1990) (56)
- Will morphing boron-based inhibitors beat the β-lactamases? (2019) (56)
- Jumonji domain containing protein 6 (Jmjd6) modulates splicing and specifically interacts with arginine–serine-rich (RS) domains of SR- and SR-like proteins (2014) (56)
- Evidence for a stereoelectronic effect in human oxygen sensing. (2009) (55)
- Dynamic states of the DNA repair enzyme AlkB regulate product release (2008) (55)
- X-ray Structure of a Serine Protease Acyl-Enzyme Complex at 0.95-Å Resolution* (2002) (55)
- Cyclic sulphamidates : new synthetic precursors for β-functionalised α-amino acids (1990) (55)
- A Cell-Permeable Ester Derivative of the JmjC Histone Demethylase Inhibitor IOX1 (2014) (55)
- Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2 (2013) (54)
- Biochemical characterization of New Delhi metallo-β-lactamase variants reveals differences in protein stability (2014) (54)
- The role of iron and 2-oxoglutarate oxygenases in signalling. (2003) (54)
- Use of (S)-N-tert-butoxycarbonylaziridine-2-carboxylate derivatives for α-amino acid synthesis (1996) (54)
- Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation (2014) (53)
- Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains (2015) (53)
- Iron-mediated cleavage of C-C bonds in vicinal tricarbonyl compounds in water. (2009) (53)
- Isolation and partial characterisation of ACV synthetase from Cephalosporium acremonium and Streptomyces clavuligerus. Evidence for the presence of phosphopantothenate in ACV synthetase. (1991) (52)
- Autocatalysed oxidative modifications to 2‐oxoglutarate dependent oxygenases (2012) (52)
- The 2‐Oxoglutarate‐Dependent Oxygenase JMJD6 Catalyses Oxidation of Lysine Residues to give 5S‐Hydroxylysine Residues (2011) (52)
- Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates. (2011) (52)
- Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase. (2013) (52)
- Structure of a specific acyl-enzyme complex formed between β-casomorphin-7 and porcine pancreatic elastase (1997) (52)
- On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury (2016) (51)
- Competitive Inhibitors of the CphA Metallo-β-Lactamase from Aeromonas hydrophila (2007) (50)
- The enzymology of clavam and carbapenem biosynthesis. (2005) (50)
- Utilization of sterol carrier protein-2 by phytanoyl-CoA 2-hydroxylase in the peroxisomal alpha oxidation of phytanic acid. (2002) (50)
- Identification of a pathogenic FTO mutation by next-generation sequencing in a newborn with growth retardation and developmental delay (2015) (50)
- Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2. (2007) (50)
- Inactivation of 1-aminocyclopropane-1-carboxylate oxidase involves oxidative modifications. (1997) (49)
- Anaerobic crystallisation of an isopenicillin N synthase.Fe(II).substrate complex demonstrated by X-ray studies. (1996) (49)
- Fast and forceful refolding of stretched alpha-helical solenoid proteins. (2010) (49)
- Structural and mechanistic studies on anthocyanidin synthase catalysed oxidation of flavanone substrates: the effect of C-2 stereochemistry on product selectivity and mechanism. (2005) (49)
- Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase. (2012) (49)
- A fluorescence-based assay for 2-oxoglutarate-dependent oxygenases. (2005) (49)
- The ring opening of aziridine-2-carboxylate esters with organometallic reagents (1989) (49)
- NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors† †Electronic supplementary information (ESI) available: All experimental details, crystallographic data collection and refinement statistics, details of chemical synthesis, additional figures and tables. See D (2016) (48)
- Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates (2019) (48)
- Product-substrate engineering by bacteria: studies on clavaminate synthase, a trifunctional dioxygenase (1999) (48)
- Isolation of dihydroclavaminic acid, an intermediate in the biosynthesis of clavulanic acid (1991) (48)
- Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors. (2013) (48)
- Glucose Metabolism and Oxygen Availability Govern Reactivation of the Latent Human Retrovirus HTLV-1 (2017) (48)
- Evidence That Two Enzyme-derived Histidine Ligands Are Sufficient for Iron Binding and Catalysis by Factor Inhibiting HIF (FIH)* (2008) (47)
- Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold. (2009) (47)
- A photoreactive small-molecule probe for 2-oxoglutarate oxygenases. (2011) (47)
- On the histone lysine methyltransferase activity of fungal metabolite chaetocin. (2013) (46)
- Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure. (2009) (45)
- Monitoring the Activity of 2‐Oxoglutarate Dependent Histone Demethylases by NMR Spectroscopy: Direct Observation of Formaldehyde (2010) (45)
- Expression, purification and characterization of 1-aminocyclopropane-1-carboxylate oxidase from tomato in Escherichia coli. (1995) (45)
- Binding of D‐ and L‐captopril inhibitors to metallo‐β‐lactamase studied by polarizable molecular mechanics and quantum mechanics (2002) (45)
- Adipocyte Pseudohypoxia Suppresses Lipolysis and Facilitates Benign Adipose Tissue Expansion (2014) (45)
- Generation of a synthetic GlcNAcylated nucleosome reveals regulation of stability by H2A-Thr101 GlcNAcylation (2015) (44)
- Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth (2014) (44)
- Hypoxia-dependent sequestration of an oxygen sensor by a widespread structural motif can shape the hypoxic response - a predictive kinetic model (2010) (43)
- A γ-lactam analogue of the penems possessing antibacterial activity (1989) (43)
- Purified recombinant hARD1 does not catalyse acetylation of Lys532 of HIF‐1α fragments in vitro (2006) (43)
- Carboxymethylproline Synthase (CarB), an Unusual Carbon-Carbon Bond-forming Enzyme of the Crotonase Superfamily Involved in Carbapenem Biosynthesis* (2004) (43)
- Crystal structure of human persulfide dioxygenase: structural basis of ethylmalonic encephalopathy (2015) (42)
- The most versatile of all reactive intermediates? (2007) (42)
- ORF17 from the Clavulanic Acid Biosynthesis Gene Cluster Catalyzes the ATP-dependent Formation of N-Glycyl-clavaminic Acid* (2006) (42)
- Dynamic combinatorial mass spectrometry leads to metallo-beta-lactamase inhibitors. (2008) (42)
- Characterization of the Human SNM1A and SNM1B/Apollo DNA Repair Exonucleases* (2012) (42)
- Comparison of Verona Integron-Borne Metallo-β-Lactamase (VIM) Variants Reveals Differences in Stability and Inhibition Profiles (2015) (41)
- Evidence for oxidation at C-3 of the flavonoid C-ring during anthocyanin biosynthesis. (2002) (41)
- The C-4 stereochemistry of leucocyanidin substrates for anthocyanidin synthase affects product selectivity. (2003) (41)
- Crystal Structure and Mechanistic Implications of N2-(2-Carboxyethyl)arginine Synthase, the First Enzyme in the Clavulanic Acid Biosynthesis Pathway* (2004) (40)
- Hydroxamate Inhibitors ofAeromonas hydrophilaAE036 Metallo-B-lactamase (1999) (40)
- Use of electrospray mass spectrometry to directly observe an acyl enzyme intermediate in β‐lactamase catalysis (1990) (40)
- HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice (2014) (39)
- Synthesis and evaluation of δ-lactams (piperazones) as elastase inhibitors (2003) (39)
- γ-Lactam analogues of carbapenicillanic acids (1985) (39)
- Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain (2015) (39)
- Studying the active-site loop movement of the São Paolo metallo-β-lactamase-1 (2014) (38)
- Studies on the reaction of glutathione and formaldehyde using NMR. (2010) (38)
- ORF6 from the clavulanic acid gene cluster of Streptomyces clavuligerus has ornithine acetyltransferase activity. (2002) (38)
- Cephalosporin biosynthesis: A branched pathway sensitive to an isotope effect (1991) (38)
- Crystal structure of the PHF8 Jumonji domain, an N ε‐methyl lysine demethylase (2010) (37)
- Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis. (2002) (37)
- Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen. (2014) (37)
- The Inhibitor Thiomandelic Acid Binds to Both Metal Ions in Metallo-β-lactamase and Induces Positive Cooperativity in Metal Binding* (2003) (37)
- Anion-exchange chromatography mass spectrometry provides extensive coverage of primary metabolic pathways revealing altered metabolism in IDH1 mutant cells (2020) (37)
- Structural/mechanistic insights into the efficacy of nonclassical β‐lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates (2017) (36)
- Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases. (2004) (36)
- Structure-guided design of cell wall biosynthesis inhibitors that overcome β-lactam resistance in Staphylococcus aureus (MRSA). (2011) (36)
- Structural Analyses on Intermediates in Serine Protease Catalysis* (2006) (36)
- Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication (2020) (35)
- Proline-Hydroxylated Hypoxia-Inducible Factor 1α (HIF-1α) Upregulation in Human Tumours (2014) (35)
- The role of PHD2 mutations in the pathogenesis of erythrocytosis (2014) (35)
- Discovery of ML324, a JMJD2 demethylase inhibitor with demonstrated antiviral activity (2013) (35)
- Inhibitors of the FEZ-1 metallo-beta-lactamase. (2007) (34)
- Structural studies on the reaction of isopenicillin N synthase with the truncated substrate analogues delta-(L-alpha-aminoadipoyl)-L-cysteinyl-glycine and delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alanine. (2005) (34)
- Rapid Identification of Novel Psychoactive and Other Controlled Substances Using Low-Field 1H NMR Spectroscopy (2019) (34)
- Observations on the deprotection of pinanediol and pinacol boronate esters via fluorinated intermediates. (2010) (34)
- Substrate specificity of l-δ-(α-aminoadipoyl)-l-cysteinyl-d-valine synthetase from Cephalosporium acremonium: demonstration of the structure of several unnatural tripeptide products (1994) (34)
- Incorporation of oxygen into the succinate co‐product of iron(II) and 2‐oxoglutarate dependent oxygenases from bacteria, plants and humans (2005) (33)
- The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes (2021) (33)
- Combined Mass Spectrometry and Dynamic Chemistry Approach to Identify Metalloenzyme Inhibitors (2007) (33)
- A substrate analogue study on clavaminic acid synthase: possible clues to the biosynthetic origin of proclavamic acid (1993) (33)
- The polyserine domain of the lysyl-5 hydroxylase Jmjd6 mediates subnuclear localization. (2013) (33)
- Characterization of the SARS-CoV-2 ExoN (nsp14ExoN–nsp10) complex: implications for its role in viral genome stability and inhibitor identification (2020) (33)
- Structural and stereoelectronic insights into oxygenase-catalyzed formation of ethylene from 2-oxoglutarate (2017) (33)
- Rationally engineered flavin‐dependent oxidase reveals steric control of dioxygen reduction (2015) (33)
- The Human Oxygen Sensing Machinery and Its Manipulation (2008) (33)
- In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors. (2018) (33)
- Inhibition of elastase by N-sulfonylaryl beta-lactams: anatomy of a stable acyl-enzyme complex. (1998) (33)
- Clavulanic acid dehydrogenase: structural and biochemical analysis of the final step in the biosynthesis of the beta-lactamase inhibitor clavulanic acid. (2007) (33)
- Assessing histone demethylase inhibitors in cells: lessons learned (2017) (33)
- Studies on deacetoxycephalosporin C synthase support a consensus mechanism for 2-oxoglutarate dependent oxygenases. (2014) (32)
- Inhibition of the HIF1α-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II). (2015) (32)
- Asparaginyl beta-hydroxylation of proteins containing ankyrin repeat domains influences their stability and function. (2009) (32)
- An approach to enzyme inhibition employing reversible boronate ester formation (2011) (32)
- Alteration of the Co-substrate Selectivity of Deacetoxycephalosporin C Synthase (2001) (32)
- Ethylene biosynthesis by 1-aminocyclopropane-1-carboxylic acid oxidase: a DFT study. (2006) (32)
- The Ugi four-component reaction enables expedient synthesis and comparison of photoaffinity probes (2013) (31)
- Molecular Basis of Class A β-Lactamase Inhibition by Relebactam (2019) (31)
- Is JmjC Oxygenase Catalysis Limited to Demethylation?** (2013) (31)
- The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids. (2005) (31)
- Direct sulfonylation of anilines mediated by visible light† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc03891g (2017) (31)
- JMJD5 is a human arginyl C-3 hydroxylase (2018) (30)
- Investigations into the post-translational modification and mechanism of isopenicillin N:acyl-CoA acyltransferase using electrospray mass spectrometry. (1993) (30)
- Controlling the Substrate Selectivity of Deacetoxycephalosporin/deacetylcephalosporin C Synthase* (2004) (30)
- Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors. (2009) (30)
- Preconditioning of Cardiosphere-Derived Cells with Hypoxia or Prolyl-4-Hydroxylase Inhibitors Increases Stemness and Decreases Reliance on Oxidative Metabolism (2016) (30)
- Reaction of (Trifluoromethyl)trimethylsilane with Oxazolidin-5-ones: Synthesis of Peptidic and Nonpeptidic Trifluoromethyl Ketones (1998) (29)
- β-Lactam synthetase: implications for β-lactamase evolution (1998) (29)
- Structural and Mechanistic Studies on Carboxymethylproline Synthase (CarB), a Unique Member of the Crotonase Superfamily Catalyzing the First Step in Carbapenem Biosynthesis* (2005) (29)
- Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases. (2015) (29)
- X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster. (2005) (29)
- Inactivation of 1-aminocyclopropane-1-carboxylate (ACC) oxidase (1994) (29)
- Profiling interactions of vaborbactam with metallo-β-lactamases (2019) (28)
- Pharmacological Inhibition of FTO (2015) (28)
- KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability (2017) (28)
- δ‐L‐(α‐Aminoadipoyl)‐L‐cysteinyl‐D‐valine synthetase: the order of peptide bond formation and timing of the epimerisation reaction (1995) (28)
- CHAPTER 2:Introduction to Structural Studies on 2-Oxoglutarate-Dependent Oxygenases and Related Enzymes (2015) (28)
- The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases (2018) (27)
- Evidence that Thienamycin Biosynthesis Proceeds via C‐5 Epimerization: ThnE Catalyzes the Formation of (2S,5S)‐trans‐Carboxymethylproline (2009) (27)
- Crotonase catalysis enables flexible production of functionalized prolines and carbapenams. (2012) (27)
- Structure of the Ribosomal Oxygenase OGFOD1 Provides Insights into the Regio- and Stereoselectivity of Prolyl Hydroxylases (2015) (27)
- Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor† (2014) (27)
- Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern (2019) (27)
- The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase. (2002) (27)
- Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor. (2013) (27)
- A New Mechanism for β‐Lactamases: Class D Enzymes Degrade 1β‐Methyl Carbapenems through Lactone Formation (2018) (27)
- Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate. (2003) (26)
- Mechanism for cyclization reaction by clavaminic acid synthase. Insights from modeling studies. (2007) (26)
- Biosynthesis of Carbapenem Antibiotics: New Carbapenam Substrates for Carbapenem Synthase (CarC) (2004) (26)
- The effect of cysteine mutations on recombinant deacetoxycephalosporin C synthase from S. clavuligerus. (2000) (26)
- Discovery of SARS-CoV-2 Mpro peptide inhibitors from modelling substrate and ligand binding (2021) (26)
- Probing the penicillin sidechain selectivity of recombinant deacetoxycephalosporin C synthase (2001) (26)
- Crystal structures of VIM‐1 complexes explain active site heterogeneity in VIM‐class metallo‐β‐lactamases (2018) (26)
- 2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2. (2009) (26)
- Histone H2A monoubiquitylation and p38-MAPKs regulate immediate-early gene-like reactivation of latent retrovirus HTLV-1. (2018) (26)
- Substrate specificity of proline 4-hydroxylase : chemical and enzymatic synthesis of 2S,3R,4S-epoxyproline (1994) (26)
- Studies on the inhibition of AmpC and other β-lactamases by cyclic boronates. (2019) (25)
- The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities (2015) (25)
- Investigations on recyclisation and hydrolysis in avibactam mediated serine β-lactamase inhibition (2016) (25)
- ESI‐MS Studies on Prolyl Hydroxylase Domain 2 Reveal a New Metal Binding Site (2008) (25)
- Reaction of ruppert's reagent (TMS-CF3) with Oxazolidinones: Synthesis of protected α-amino trifluoromethylketones (1995) (25)
- Does the observation of noncovalent complexes between biomolecules by electrospray ionisation mass spectrometry necessarily reflect specific solution interactions (1994) (25)
- Stereoselective C-C bond formation catalysed by engineered carboxymethylproline synthases. (2011) (25)
- The emzymatic ring expansion of penicillins to cephalosporins : side chain specificity (1987) (25)
- Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model (2020) (25)
- Using NMR solvent water relaxation to investigate metalloenzyme-ligand binding interactions. (2010) (24)
- SYNTHESIS OF (2S, 3R, 4S), (2S, 3S, 4R)-EPOXYPROLINES AND AMINOHYDROXYPROLINES (1998) (24)
- Structure guided development of potent reversibly binding penicillin binding protein inhibitors. (2011) (24)
- New Delhi Metallo-β-Lactamase 1 Catalyzes Avibactam and Aztreonam Hydrolysis (2017) (24)
- β-Sultams—A novel class of serine protease inhibitors (2001) (24)
- Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-β-lactamase inhibition. (2017) (24)
- Thioester hydrolysis and C-C bond formation by carboxymethylproline synthase from the crotonase superfamily. (2008) (24)
- ‘Chemical co-substrate rescue’ of phytanoyl-CoA 2-hydroxylase mutants causing Refsum’s Disease (2001) (24)
- A boronic-acid-based probe for fluorescence polarization assays with penicillin binding proteins and β-lactamases. (2012) (24)
- Triflic anhydride-mediated synthesis of oxazoles (2009) (24)
- 2-Oxoglutarate oxygenases are inhibited by a range of transition metals. (2010) (24)
- NMR analyses on N-hydroxymethylated nucleobases – implications for formaldehyde toxicity and nucleic acid demethylases† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8ob00734a (2018) (23)
- DNA aptamers for as analytical tools for the quantitative analysis of DNA-dealkylating enzymes. (2011) (23)
- Purification, crystallization and preliminary X-ray diffraction of anthocyanidin synthase from Arabidopsis thaliana. (2001) (23)
- Cyclobutanone Mimics of Intermediates in Metallo‐β‐Lactamase Catalysis (2018) (23)
- Isopenicilin N synthase: a new mode of reactivity (1992) (23)
- 11B NMR studies of an aryl boronic acid bound to chymotrypsin and subtilisin (1991) (23)
- Non‐Hydrolytic β‐Lactam Antibiotic Fragmentation by l,d‐Transpeptidases and Serine β‐Lactamase Cysteine Variants (2019) (23)
- Reactions of a glycidyl radical equivalent with 2-functionalised allyl stannanes (1988) (23)
- Improved synthesis of 5-hydroxymethyl-2'-deoxycytidine phosphoramidite using a 2'-deoxyuridine to 2'-deoxycytidine conversion without temporary protecting groups. (2011) (23)
- Direct analysis of enzyme-catalyzed DNA demethylation. (2009) (23)
- Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor. (2010) (23)
- Structure-Based in Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library (2019) (23)
- Catalysis by the Non-Heme Iron(II) Histone Demethylase PHF8 Involves Iron Center Rearrangement and Conformational Modulation of Substrate Orientation (2019) (23)
- Chromophore‐Linked Substrate (CLS405): Probing Metallo‐β‐Lactamase Activity and Inhibition (2013) (23)
- γ-Lactam formation from tripeptides with isopenicillin N synthase (1988) (22)
- Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates (2017) (22)
- Molecular dynamics simulations of the acyl‐enzyme and the tetrahedral intermediate in the deacylation step of serine proteases (2002) (22)
- Isocitrate dehydrogenase variants in cancer — Cellular consequences and therapeutic opportunities (2020) (22)
- A Noninvasive Comparison Study between Human Gliomas with IDH1 and IDH2 Mutations by MR Spectroscopy (2018) (22)
- C−H Cyanation of 6‐Ring N‐Containing Heteroaromatics (2017) (22)
- The unusual bifunctional catalysis of epimerization and desaturation by carbapenem synthase. (2004) (22)
- Active site mutations of recombinant deacetoxycephalosporin C synthase. (2002) (22)
- Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors (2021) (22)
- Analytical determination of heroin, fentanyl and fentalogues using high-performance liquid chromatography with diode array and amperometric detection (2019) (22)
- Synthesis of a bicyclic γ-lactam dipeptide analogue (1993) (22)
- Investigating d-lysine stereochemistry for epigenetic methylation, demethylation and recognition. (2017) (22)
- The inhibition of metallo-β-lactamase by thioxo-cephalosporin derivatives (2004) (21)
- Mapping the Hydrophobic Substrate Binding Site of Phenylalanine Ammonia-Lyase from Petroselinum crispum (2019) (21)
- Mechanistic Insights into β-Lactamase-Catalysed Carbapenem Degradation Through Product Characterisation (2019) (21)
- Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles. (2010) (21)
- Mechanical anisotropy of ankyrin repeats. (2012) (21)
- Proline 4-hydroxylase: Stereochemical course of the reaction (1993) (21)
- A comparison of 2‐hydroxyglutarate detection at 3 and 7 T with long‐TE semi‐LASER (2018) (20)
- Studies on phytanoyl-CoA 2-hydroxylase and synthesis of phytanoyl-coenzyme A. (2001) (20)
- Synthesis of potential β-turn bicyclic dipeptide mimetics (1993) (20)
- Studies on ternary metallo-β lactamase-inhibitor complexes using electrospray ionization mass spectrometry (2006) (20)
- 13C-Carbamylation as a mechanistic probe for the inhibition of class D β-lactamases by avibactam and halide ions. (2017) (20)
- Structure and Mechanism of a Viral Collagen Prolyl Hydroxylase (2015) (20)
- Synthesis of a novel bicyclic γ-lactam analogue of the 1-oxapenams (1989) (20)
- 2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2† †Electronic supplementary information (ESI) available: Details of experimental procedures and additional experiments. See DOI: 10.1039/c8cc00387d (2018) (20)
- Expanding the yeast protein arginine methylome (2015) (20)
- Comments on the Use of Diphenyloxazinone Derivatives as Glycine Anion Templates for Amino Acid Synthesis (1992) (20)
- Structural and mechanistic studies on the peroxisomal oxygenase phytanoyl-CoA 2-hydroxylase (PhyH). (2007) (20)
- Improved Localization for 2-Hydroxyglutarate Detection at 3 T Using Long-TE Semi-LASER (2016) (19)
- Normal tissue radioprotection by amifostine via Warburg-type effects (2016) (19)
- 1,3,5-Trisubstituted benzenes as fluorescent photoaffinity probes for human carbonic anhydrase II capture. (2013) (19)
- Binding of (5S)-penicilloic acid to penicillin binding protein 3. (2013) (19)
- Development and Application of a Fluoride‐Detection‐Based Fluorescence Assay for γ‐Butyrobetaine Hydroxylase (2012) (19)
- Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2. (2009) (19)
- 1 The biosynthesis of ß-lactams (1992) (18)
- Isopenicillin N synthase: a new mode of reactivity (1991) (18)
- γ-Butyrobetaine hydroxylase catalyses a Stevens type rearrangement. (2012) (18)
- Role of Structural Dynamics in Selectivity and Mechanism of Non-heme Fe(II) and 2-Oxoglutarate-Dependent Oxygenases Involved in DNA Repair (2020) (18)
- 19F‐NMR Reveals the Role of Mobile Loops in Product and Inhibitor Binding by the São Paulo Metallo‐β‐Lactamase (2017) (18)
- The Clinically Used Iron Chelator Deferasirox is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases. (2019) (18)
- HIF hydroxylase inhibitors decrease cellular oxygen consumption depending on their selectivity (2019) (18)
- Epimerization and desaturation by carbapenem synthase (CarC). A hybrid DFT study (2006) (18)
- Synthesis of metallo-β-lactamase inhibitors (1997) (18)
- Inhibition of 1-aminocyclopropane-1-carboxylate oxidase by 2-oxoacids (1996) (18)
- Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19 (2021) (18)
- Expression in Escherichia coli of a clavaminic acid synthase isozyme : a trifunctional oxygenase involved in clavulanic acid biosynthesis (1994) (18)
- Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in β-lactam biosynthesis (2018) (18)
- Isolation of an intermediate in clavulanic acid biosynthesis (1990) (17)
- Observation of enzyme bound intermediates in the biosynthesis of preuroporphyrinogen by PBG deaminase (1991) (17)
- Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases (2018) (17)
- Mechanistic studies on the application of DNA aptamers as inhibitors of 2-oxoglutarate-dependent oxygenases. (2012) (17)
- Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo† †Electronic supplementary information (ESI) available: General experimental procedures and supplementary figures. See DOI: 10.1039/c6cc00529b Click here for additional data file. (2016) (17)
- Kruidenier et al. reply (2014) (17)
- MeLAD: an integrated resource for metalloenzyme-ligand associations (2019) (17)
- Modulating carnitine levels by targeting its biosynthesis – selective inhibition of γ-butyrobetaine hydroxylase (2014) (17)
- Cation–π Interactions Contribute to Substrate Recognition in γ‐Butyrobetaine Hydroxylase Catalysis (2015) (17)
- Cephalosporin C biosynthesis; a branched pathway sensitive to a kinetic isotope effect (1987) (17)
- The enzymatic conversion of exomethylene cephalosporin c into deacetyl cephalosporin c and the role of molecular oxygen in cephalosporin c biosynthesis (1988) (17)
- Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases. (2008) (17)
- Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion. (2013) (17)
- Synthesis of regio- and stereoselectively deuterium-labelled derivatives of L-glutamate semialdehyde for studies on carbapenem biosynthesis. (2009) (17)
- Assay for drug discovery: Synthesis and testing of nitrocefin analogues for use as β-lactamase substrates. (2015) (17)
- Tripeptide LY301621 and its diastereomers as methicillin potentiators against methicillin resistant Staphylococcus aureus. (1997) (16)
- Structural and Biochemical Characterization of Rm3, a Subclass B3 Metallo-β-Lactamase Identified from a Functional Metagenomic Study (2016) (16)
- Crystallization and preliminary X‐ray diffraction studies on recombinant isopenicillin N synthase from Aspergillus nidulans (1995) (16)
- Quantification of MDMA in seized tablets using benchtop 1H NMR spectroscopy in the absence of internal standards (2020) (16)
- Revised structures for Tü 1718B and valclavam (1993) (16)
- Deciphering Functions of Intracellular Formaldehyde: Linking Cancer and Aldehyde Metabolism. (2018) (16)
- Hitting the Jackpot - Development of gas chromatography-mass spectrometry (GC-MS) and other rapid screening methods for the analysis of 18 fentanyl-derived synthetic opioids. (2020) (16)
- Use of ferrous iron by metallo-β-lactamases (2016) (16)
- Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase. (2011) (16)
- Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway (2010) (15)
- Substrate analogues and inhibition of ACC oxidase: conversion of D-valine to iso-butanal (1998) (15)
- 5,5-Fused thiophene γ-lactams as templates for serine protease inhibition (2002) (15)
- Inhibitors of both the N-methyl lysyl- and arginyl-demethylase activities of the JmjC oxygenases (2018) (15)
- Syntheses of (S)-β-pyrazolylalanine and (S)-quisqualic acid from a serine-derived aziridine (1996) (15)
- New structural insights into the inhibition of serine proteases by cyclic peptides from bacteria. (2003) (15)
- Enzymatic ring expansion of penicillins to cephalosporins: side chain specificity (1987) (15)
- Open Science Discovery of Potent Non-Covalent SARS-CoV-2 Main Protease Inhibitors (2023) (15)
- Sideromimic Modification of Lactivicin Dramatically Increases Potency against Extensively Drug-Resistant Stenotrophomonas maltophilia Clinical Isolates (2016) (15)
- Structural basis for the interaction of lactivicins with serine beta-lactamases. (2010) (15)
- Assay platform for clinically relevant metallo-beta-lactamases (2013) (15)
- Chemical basis for the selectivity of the von Hippel Lindau tumor suppressor pVHL for prolyl-hydroxylated HIF-1alpha. (2010) (15)
- An essential role for dNTP homeostasis following CDK-induced replication stress (2018) (15)
- An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography (2021) (15)
- Oxidation of deacetylcephalosporin C by deacetoxycephalosporin C/deacetylcephalosporin C synthase. (1992) (15)
- The broad spectrum 2-oxoglutarate oxygenase inhibitor N-oxalylglycine is present in rhubarb and spinach leaves. (2015) (15)
- Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β-Lactamase from Escherichia coli (2020) (15)
- Substrate specificity of cloned deacetoxycephalosporin C/deacetylcephalosporin C synthetase. (1988) (14)
- Cyclic boronates as versatile scaffolds for KPC-2 β-lactamase inhibition. (2020) (14)
- The ring expansion of penama to cephams: a possible biomimetic process (1988) (14)
- Self- hydroxylation of the splicing factor lysyl hydroxylase, JMJD6 (2012) (14)
- Studies on the specificity of unprocessed and mature forms of phytanoyl-CoA 2-hydroxylase and mutation of the iron binding ligands Published, JLR Papers in Press, June 1, 2005. DOI 10.1194/jlr.M500034-JLR200 (2005) (14)
- Antibiotics as food for bacteria (2018) (14)
- δ‐l‐(α‐Aminoadipoyl)‐l‐cysteinyl‐d‐valine synthetase: isolation of l‐cysteinyl‐d‐valine, a ‘shunt’ product, and implications for the order of peptide bond formation (1995) (14)
- Enantiospecific synthesis of dealanylalahopcin (1990) (14)
- Conformational Dynamics Underlies Different Functions of Human KDM7 Histone Demethylases. (2019) (14)
- Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases (2018) (14)
- Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor (2017) (13)
- Fluoromethylated derivatives of carnitine biosynthesis intermediates--synthesis and applications. (2014) (13)
- Kinetic parameters of human aspartate/asparagine–β-hydroxylase suggest that it has a possible function in oxygen sensing (2020) (13)
- Reversible acylation of elastase by γ-lactam analogues of β-lactam inhibitors (1997) (13)
- Synthesis of L-ornithines stereospecifically deuterated at C-3 (1993) (13)
- Ring expansion of penams to cephams: a possible biomimetic process (1987) (13)
- Oxygenase-Catalyzed Desymmetrization of N,N-Dialkyl-piperidine-4-carboxylic Acids** (2014) (13)
- Structures of Mycobacterium tuberculosis Penicillin-Binding Protein 3 in Complex with Five β-Lactam Antibiotics Reveal Mechanism of Inactivation (2020) (13)
- The potential of 2-oxoglutarate oxygenases acting on nucleic acids as therapeutic targets (2012) (13)
- Preclinical Evaluation of Discorhabdins in Antiangiogenic and Antitumor Models (2018) (13)
- Comparison of the substrate selectivity and biochemical properties of human and bacterial γ-butyrobetaine hydroxylase. (2014) (13)
- 'pH-jump' crystallographic analyses of gamma-lactam-porcine pancreatic elastase complexes. (2000) (13)
- Mass spectrometry reveals potential of b -lactams as SARS-CoV-2 M pro inhibitors † (2021) (13)
- Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition (2021) (13)
- Structural and mechanistic studies on N(2)-(2-carboxyethyl)arginine synthase. (2009) (13)
- X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis (2021) (13)
- BETA -LACTAM SYNTHETASE : IMPLICATIONS FOR BETA -LACTAMASE EVOLUTION (1998) (13)
- Structure‐Activity Relationship and Crystallographic Studies on 4‐Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors (2019) (12)
- Synthesis and analysis of Leu-enkephalin analogues containing reverse turn peptidomimetics (1996) (12)
- Anatomy of a simple acyl intermediate in enzyme catalysis: combined biophysical and modeling studies on ornithine acetyl transferase. (2009) (12)
- JMJD6 Is a Druggable Oxygenase That Regulates AR-V7 Expression in Prostate Cancer (2021) (12)
- Structural and mechanistic studies on gamma-butyrobetaine hydroxylase. (2010) (12)
- Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6 (2019) (12)
- Syntheses of (6S)-Cephalosporins from 6-Aminopenicillanic Acid (2000) (12)
- The role of α-ketoglutarate in cephalosporin biosynthesis (1989) (12)
- The synthesis of potential γ-lactam antibiotics containing a cycloserine nucleus (1990) (12)
- Analysis of JmjC Demethylase-Catalyzed Demethylation Using Geometrically-Constrained Lysine Analogues. (2016) (12)
- Synthesis of deuterium labelled L- and D-glutamate semialdehydes and their evaluation as substrates for carboxymethylproline synthase (CarB)--implications for carbapenem biosynthesis. (2005) (12)
- Kinetics and mechanisms of hydrolysis and aminolysis of thioxocephalosporins. (2004) (11)
- Natural variants modify Klebsiella pneumoniae carbapenemase (KPC) acyl–enzyme conformational dynamics to extend antibiotic resistance (2020) (11)
- An investigation into the mechanism of elastase inhibition by cephalosporins using electrospray ionisation mass spectrometry (1993) (11)
- Contributions of cardiac “funny” (f) channels and sarcoplasmic reticulum Ca2+ in regulating beating rate of mouse and guinea pig sinoatrial node (2015) (11)
- Crotonases: Nature’s Exceedingly Convertible Catalysts (2017) (11)
- Broad Spectrum β-lactamase Inhibition by a Thioether Substituted Bicyclic Boronate. (2019) (11)
- Stepwise hydrogen removal in the enzymic ring expansion of penicillin N to deacetoxycephalosporin C (1987) (11)
- Studies on the selectivity of proline hydroxylases reveal new substrates including bicycles (2019) (11)
- Unusually stable azetidinone sulfenic acids (1998) (11)
- Rh(III)-Catalyzed directed C–H carbenoid coupling reveals aromatic bisphosphonates inhibiting metallo- and Serine-β-lactamases (2018) (11)
- Mechanism of molecular oxygen diffusion in a hypoxia sensing prolyl hydroxylase using multiscale simulation. (2020) (11)
- The origin of the β-lactam carbons of clavulanic acid (1997) (11)
- Mutagenesis studies on the iron binding ligands of clavaminic acid synthase. (2000) (11)
- Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 Mpro inhibitors† †Electronic supplementary information (ESI) available: Experimental details and inhibition data. See DOI: 10.1039/d0cc06870e (2021) (11)
- Crystal structures of an oligopeptide-binding protein from the biosynthetic pathway of the beta-lactamase inhibitor clavulanic acid. (2010) (11)
- Targeting the Mycobacterium tuberculosis transpeptidase LdtMt2 with cysteine-reactive inhibitors including ebselen† †Electronic supplementary information (ESI) available: Experimental details, IC50 curves, mass spectra, electron density maps. See DOI: 10.1039/c9cc04145a (2019) (11)
- Catalysis by the JmjC histone demethylase KDM4A integrates substrate dynamics, correlated motions and molecular orbital control† (2020) (11)
- Enzymes of valclavam biosynthesis (1994) (11)
- Enzymatic Synthesis of Monocyclic β-Lactams (2002) (11)
- Structural Basis of Metallo-β-lactamase Inhibition by N-Sulfamoylpyrrole-2-carboxylates (2021) (11)
- The SNM1A DNA repair nuclease (2020) (10)
- Ejection of structural zinc leads to inhibition of γ-butyrobetaine hydroxylase. (2014) (10)
- Adipoyl-6-aminopenicillanic acid is a substrate for deacetoxycephalosporin C synthase (DAOCS) (1996) (10)
- Studies on the stereospecificity of the clavaminic acid synthase catalysed hydroxylation reaction (1993) (10)
- Biosynthetic precursors of valclavam (1994) (10)
- Comments on the use of a dichromophoric circular dichroism assay for the identification of beta-turns in peptides. (2009) (10)
- Non-competitive cyclic peptides for targeting enzyme–substrate complexes† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc00286j (2018) (10)
- 19F NMR Monitoring of Reversible Protein Post‐Translational Modifications: Class D β‐Lactamase Carbamylation and Inhibition (2019) (10)
- Roles of metal ions in the selective inhibition of oncogenic variants of isocitrate dehydrogenase 1 (2021) (10)
- Non-invasive quantification of 2-hydroxyglutarate in human gliomas with IDH 1 and IDH 2 mutations (2017) (10)
- Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat (2021) (10)
- Conformational flexibility influences structure-function relationships in nucleic acid N-methyl demethylases. (2019) (10)
- Thiomandelic Acid, a Broad Spectrum Inhibitor of Zinc β-Lactamases (2001) (10)
- Hypoxia and hypoxia mimetics differentially modulate histone post-translational modifications (2020) (10)
- Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors (2020) (9)
- CHAPTER 6:The Role of 2-Oxoglutarate-Dependent Oxygenases in Hypoxia Sensing (2015) (9)
- Formation of a novel bicyclic γ-lactam with isopenicillin N synthase (1989) (9)
- Studies on the mechanism of deacetoxy–deacetylcephalosporin C synthase using cyclopropyl substituted cephalosporin probes (1991) (9)
- Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6. (2010) (9)
- L-delta-(alpha-Aminoadipoyl)-L-cysteinyl-D-valine synthetase: thioesterification of valine is not obligatory for peptide bond formation. (1997) (9)
- Inhibition of the Oxygen-Sensing Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-Inducible Factor: A Potential Hypoxia Response Modulating Strategy. (2021) (9)
- The role of molecular oxygen in cephalosporin C biosynthesis (1987) (9)
- Studies on the Glutathione-Dependent Formaldehyde-Activating Enzyme from Paracoccus denitrificans (2015) (9)
- Synthesis and Biological Evaluation of Tripartin, a Putative KDM4 Natural Product Inhibitor, and 1‐Dichloromethylinden‐1‐ol Analogues (2018) (9)
- Chemo-enzymatic synthesis of bicyclic γ-lactams using clavaminic acid synthase (1997) (9)
- Kinetic and crystallographic analysis of complexes formed between elastase and peptides from beta-casein. (2001) (9)
- “To Cross-Seed or Not To Cross-Seed”: A Pilot Study Using Metallo-β-lactamases (2017) (8)
- A prodrug system for hydroxylamines based on esterase catalysis. (2005) (8)
- Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease (2018) (8)
- Stereoselective preparation of lipidated carboxymethyl-proline/pipecolic acid derivatives via coupling of engineered crotonases with an alkylmalonyl-CoA synthetase. (2013) (8)
- A Fluorescence‐Based Assay for Screening β‐Lactams Targeting the Mycobacterium tuberculosis Transpeptidase LdtMt2 (2019) (8)
- Studies of isopenicillin N synthase enzymatic properties using a continuous spectrophotometric assay (2000) (8)
- OS-9: another piece in the HIF complex story. (2005) (8)
- Human Uty(Kdm6C) is a Male-Specific Nepislon-Methyl Lysyl Demethylase. (2013) (8)
- Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-N ε-trimethyllysine† †Electronic supplementary information (ESI) available: Synthesis procedures, assay conditions, NMR assignments and spectra, and MS analyses. See DOI: 10.1039/c6cc08381a Click here for additional data file. (2016) (8)
- Studies on the inhibition of porcine pancreatic elastase using electrospray mass spectrometry (1992) (8)
- Anaerobic fixed-target serial crystallography (2020) (8)
- Quantitative MS‐Based Proteomics: Comparing the MCF‐7 Cellular Response to Hypoxia and a 2‐Oxoglutarate Analogue (2020) (8)
- Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane (2022) (8)
- Mechanistic and structural studies of KDM‐catalysed demethylation of histone 1 isotype 4 at lysine 26 (2018) (8)
- Substrate analogue studies on clavaminic acid synthase (1993) (8)
- The kinetic properties of various R258 mutants of deacetoxycephalosporin C synthase. (2003) (8)
- Faropenem reacts with serine and metallo-β-lactamases to give multiple products. (2021) (8)
- Conformational studies on substituted ε-caprolactams by X-ray crystallography and NMR spectroscopy (2014) (8)
- Mass spectrometric studies on the inhibition of TEM-2 beta-lactamase by clavulanic acid derivatives. (1997) (8)
- Terminally Truncated Isopenicillin N Synthase Generates a Dithioester Product: Evidence for a Thioaldehyde Intermediate during Catalysis and a New Mode of Reaction for Non‐Heme Iron Oxidases (2017) (8)
- Substrate specificity of L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase from Cephalosporium acremonium: demonstration of the structure of several unnatural tripeptide products. (1994) (7)
- Exploiting Electrode Nanoconfinement to Investigate the Catalytic Properties of Isocitrate Dehydrogenase (IDH1) and a Cancer-Associated Variant (2021) (7)
- Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway. (2013) (7)
- Pseudomonas expression of an oxygen sensing prolyl hydroxylase homologue regulates neutrophil host responses in vitro and in vivo (2017) (7)
- Synthesis and conformational analysis of cyclic analogues of inverse gamma-turns. (2008) (7)
- Use of electrospray mass spectrometry to investigate the inhibition of β-lactamases by 6-halogenopenicillanic acids (1993) (7)
- In vitro and in vivo activity of ML302F: a thioenolate inhibitor of VIM-subfamily metallo β-lactamases (2016) (7)
- An effective substitute for α-aminoadipic acid in the enzymatic synthesis of penicillins (1987) (7)
- Exchange of the valine 2-H in the biosynthesis of L-δ-(α-aminoadipoyl)-L-Cysteinyl-D-valine (1993) (7)
- The Enzymology of Clavam and Carbapenem Biosynthesis (2006) (7)
- Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors (2022) (7)
- The Stereospecific Synthesis of alahopcin (1991) (7)
- Analysis of β-lactone formation by clinically observed carbapenemases informs on a novel antibiotic resistance mechanism (2020) (7)
- Studies on non-haem ferrous-dependent oxygenases and oxidases. (1997) (7)
- Identifying Small‐Molecule Binding Sites for Epigenetic Proteins at Domain–Domain Interfaces (2018) (7)
- The reaction of Tms-Cf3 with Amino Acid Derived Ring-Templates: Studies with Oxazin-2-Ones and Oxazolidin-5-Ones (2000) (6)
- Lysine‐241 Has a Role in Coupling 2OG Turnover with Substrate Oxidation During KDM4‐Catalysed Histone Demethylation (2018) (6)
- Mass spectrometry reveals elastase inhibitors from the reactive centre loop of alpha1-antitrypsin. (2000) (6)
- Metabolic adaptations in cancers expressing isocitrate dehydrogenase mutations (2021) (6)
- Synthesis of Novel Pyridine‐Carboxylates as Small‐Molecule Inhibitors of Human Aspartate/Asparagine‐β‐Hydroxylase (2020) (6)
- Mass Spectrometric Assays Reveal Discrepancies in Inhibition Profiles for the SARS‐CoV‐2 Papain‐Like Protease (2022) (6)
- STUDIES ON THE REACTIVITY OF AZETIDIN-2-ONES IN PHOSPHATE BUFFER (1997) (6)
- Development and application of ligand-based NMR screening assays for γ-butyrobetaine hydroxylase†‡ (2016) (6)
- Generation, validation and humanisation of a novel insulin resistant cell model. (2010) (6)
- Use of Methylmalonyl‐CoA Epimerase in Enhancing Crotonase Stereoselectivity (2016) (6)
- An efficient substitute for the α-amimoadipoyl moiety of δ-(-α-aminloadipoytl)--cisteintl--valine in the emzymatic synthesis of penicillins (1987) (6)
- What is The Catalytic Mechanism of Enzymatic Histone N-Methyl Arginine Demethylation and Can it be Influenced by an External Electric Field? (2021) (6)
- Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8md00548f (2019) (6)
- Side chain specificity in the pnzymatic synthesis of eenicillins (1990) (6)
- Design and enantioselective synthesis of 3-(α-acrylic acid) benzoxaboroles to combat carbapenemase resistance† (2021) (6)
- Cephalosporin C biosynthesis; stereochemistry of the incorporation of D,L,D-α-aminodipoyl-cysteinyl-(3S)-[2-2H,4-13C]valine into β-lactam compounds (1989) (6)
- Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2 (2022) (6)
- Photoactivable peptides for identifying enzyme-substrate and protein-protein interactions. (2011) (6)
- Isocitrate dehydrogenase gene variants in cancer and their clinical significance (2021) (6)
- Structural Investigations of the Inhibition of Escherichia coli AmpC β-Lactamase by Diazabicyclooctanes (2020) (5)
- Formaldehyde quantification using ampicillin is not selective (2019) (5)
- The Ugi Four-Component Reaction Enables Expedient Synthesis and Comparison of Photoaffinity Probes. (2014) (5)
- Syntheses of [2‐13C] and [1,2‐13C] labelled α‐ketoglutaric acid (1989) (5)
- 1-Aminocyclopropane-1-Carboxylate Oxidase: Molecular Structure and Catalytic Function (1997) (5)
- Reaction of Clavams with Elastase Reveals a General Method for Inhibiting ‘Serine’ Enzymes (2000) (5)
- YcfDRM is a thermophilic oxygen-dependent ribosomal protein uL16 oxygenase (2018) (5)
- Detection, discrimination and quantification of amphetamine, cathinone and nor-ephedrine regioisomers using benchtop 1 H and 19 F NMR spectroscopy. (2021) (5)
- Expansion of base excision repair compensates for a lack of DNA repair by oxidative dealkylation in budding yeast (2019) (5)
- Small-molecule active pharmaceutical ingredients of approved cancer therapeutics inhibit human aspartate/asparagine-β-hydroxylase (2020) (5)
- Studies on the exchange of valine-oxygen during the biosynthesis of δ-(L-α-Aminoadipoyl)-L-cysteinyl-D-valine. (1992) (5)
- One-Step Synthesis of Photoaffinity Probes for Live-Cell MS-Based Proteomics. (2021) (5)
- 1 KINETIC RATIONALE FOR SELECTIVITY TOWARDS NAND C-TERMINAL OXYGEN DEPENDENT DEGRADATION DOMAIN SUBSTRATES MEDIATED BY A LOOP REGION OF HIF PROLYL HYDROXYLASES (2007) (5)
- Synthesis and Evaluation of 3-( Dihydroxyboryl ) benzoic Acids as D , D-Carboxypeptidase R 39 Inhibitors (2009) (5)
- Stereoselective Production of Dimethyl-Substituted Carbapenams via Engineered Carbapenem Biosynthesis Enzymes (2017) (5)
- Human Oxygenase Variants Employing a Single Protein FeII Ligand Are Catalytically Active (2021) (5)
- Competitive inhibitors of the CphA metallo-beta-lactamase from Aeromonas hydrophila (2007) (5)
- Activation of Hypoxia-Inducible Factor by Di-Methyl Oxalyl Glycine (DMOG) Increases Neovascularization within Ischaemic Myocardium in a Porcine Coronary Artery Occlusion Model (2011) (5)
- The fate of valine-oxygen during penicillin biosynthesis (1989) (5)
- β-lactam chemistry (1997) (5)
- Penicillin Derivatives Inhibit the SARS-CoV-2 Main Protease by Reaction with Its Nucleophilic Cysteine (2022) (5)
- MeDBA: the Metalloenzyme Data Bank and Analysis platform (2022) (4)
- Studies on the Substrate Selectivity of the Hypoxia‐Inducible Factor Prolyl Hydroxylase 2 Catalytic Domain (2018) (4)
- Cyclic Boronates Inhibit All Classes of -Lactamases. Antimicrobial (2016) (4)
- An Investigation of the N-Arylsulfonylation of 2-Azetidinones (1997) (4)
- Author Correction: Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model (2020) (4)
- Crystallization and preliminary X-ray diffraction studies on a recombinant isopenicillin N synthase from Cephalosporium acremonium. (1994) (4)
- Analysis of β-lactone formation by clinically observed carbapenemases informs on a novel antibiotic resistance mechanism. (2020) (4)
- A human protein hydroxylase that accepts D-residues (2020) (4)
- delta-L-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase: the order of peptide bond formation and timing of the epimerisation reaction. (1995) (4)
- Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors (2021) (4)
- Syntheses of (6S,7S)- and (6S,7R)-deacetoxycephalosporanic acids from 6-aminopenicillanic acid (1996) (4)
- Nuclear entry and export of FIH are mediated by HIF1α and exportin1, respectively (2018) (4)
- Biocatalytic production of bicyclic β-lactams with three contiguous chiral centres using engineered crotonases (2019) (4)
- High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes (2021) (4)
- Syntheses of (S)-β-Pyrazolylalanine and (S)-Quisqualic Acid from a Serine-Derived Aziridine. (1996) (4)
- Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens (2018) (4)
- Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-β-hydroxylase (2020) (4)
- Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases (2021) (4)
- Small-molecules that covalently react with a human prolyl hydroxylase – towards activity modulation and substrate capture† †Electronic supplementary information (ESI) available: Synthesis, mass spectrometry, inhibition assays, mutagenesis. See DOI: 10.1039/c8cc07706a (2018) (3)
- Structure‐Activity Studies Reveal Scope for Optimisation of Ebselen‐Type Inhibition of SARS‐CoV‐2 Main Protease (2021) (3)
- JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells. (2021) (3)
- Cephalosporins Inhibit Human Metallo β-Lactamase Fold DNA Repair Nucleases SNM 1 A and SNM 1 B / Apollo (2016) (3)
- Fluoromethylated Derivatives of Carnitine biosynthesis Intermediates — Synthesis and Applications. (2014) (3)
- In Vitro Enzyme Assays for JmjC‐Domain‐Containing Lysine Histone Demethylases (JmjC‐KDMs) (2018) (3)
- Inhibition of a viral prolyl hydroxylase. (2019) (3)
- Oxygenases for oxygen sensing (2008) (3)
- Inhibition of JMJD6 by 2‐Oxoglutarate Mimics (2021) (3)
- 2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases (2021) (3)
- Synthesis of (2S,3R,4S), (2S,3S,4R)‐Epoxyprolines and Aminohydroxyprolines. (1998) (3)
- Structural studies on the reaction of isopenicillin N synthase with the substrate analogue δ -( L - α -aminoadipoyl)- L -cysteinyl- D - α -aminobutyrate (2003) (3)
- Reducing Agent‐Mediated Nonenzymatic Conversion of 2‐Oxoglutarate to Succinate: Implications for Oxygenase Assays (2020) (3)
- Investigations on Zinc Isotope Fractionation in Breast Cancer Tissue Using in vitro Cell Culture Uptake-Efflux Experiments (2022) (3)
- Enzymatic synthesis of bicyclic γ-lactams using clavaminic acid synthase (1992) (3)
- Structural and biochemical analyses reveal how ornithine acetyl transferase binds acidic and basic amino acid substrates. (2011) (3)
- Structural Basis of Metallo- (cid:2) -Lactamase Inhibition by Captopril Stereoisomers (2015) (3)
- Molecular mechanism of the multifunctional enzyme l-δ-(α-aminoadipoyl)-l-cysteinyl-d-valine (ACV) synthetase (1995) (3)
- Studies on ternary metallo-beta lactamase-inhibitor complexes using electrospray ionization mass spectrometry. (2006) (3)
- First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53 (2021) (3)
- The inhibition of metallo-beta-lactamase by thioxo-cephalosporin derivatives. (2004) (3)
- 74 Pro-Angiogenic Effects of the Prolyl-hydroxylase Inhibitor FG-2216/BIQ: Therapeutic Angiogenesis for the Treatment of Chronic Total Occlusions (2014) (2)
- Demonstration of protocadherin X/Y immunoreactive neurones in human cerebral cortex (2002) (2)
- Natural variants modify Klebsiella pneumoniae carbapenemase (KPC) acyl-enzyme conformational dynamics to extend antibiotic resistance. (2020) (2)
- Author response: Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates (2019) (2)
- Identification of valid housekeeping genes for quantitative RT-PCR analysis of cardiosphere-derived cells preconditioned under hypoxia or with prolyl-4-hydroxylase inhibitors (2011) (2)
- Penicillin biosynthesis : dependence of substrate stereochemistry on the mode of second ring closure (1990) (2)
- Synthesis of δ-lactam (2-oxopiperazine) inhibitors of elastase (2005) (2)
- Role of phytanoyl-CoA 2-hydroxylase in phytanic acid metabolism. (2003) (2)
- Discovery of neuroprotective agents that inhibit human prolyl hydroxylase PHD2. (2021) (2)
- β-Lactam Synthetase: Implications for β-Lactamase Evolution. (2010) (2)
- Adventures in Defining Roles of Oxygenases in the Regulation of Protein Biosynthesis. (2018) (2)
- Peptide mapping of the active site of Bacillus cereusβ-lactamase I by the use of high pressure liquid chromatography coupled to electrospray ionisation mass spectrometry (1994) (2)
- Cyclic Sulfamidates: New Synthetic Precursors for - Functionalized a-Amino Acids. (1991) (2)
- Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding (2019) (2)
- A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family (2021) (2)
- A Fluorescent Benzo[g]isoquinoline‐Based HIF Prolyl Hydroxylase Inhibitor for Cellular Imaging (2018) (2)
- DEACETOXYCEPHALOSPORIN C SYNTHASE FROM S. CLAVULIGERUS (1999) (2)
- Modulating carnitine levels by targeting its biosynthesis pathway - selective inhibition of γ-butyrobetaine hydroxylase. (2014) (2)
- Penicillin biosynthesis: active substrates derived by methoxy substitution in the valinyl residue of the natural substrate (1989) (2)
- Quantifying the Binding Interaction between the Hypoxia-Inducible Transcription Factor and the von Hippel-Lindau Suppressor. (2015) (2)
- Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii (2020) (2)
- Improved Synthesis of Phosphoramidite-Protected N6-Methyladenosine via BOP-Mediated SNAr Reaction (2020) (2)
- The Origin of the β‐Lactam Carbons of Clavulanic Acid. (1997) (2)
- Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2 (2020) (2)
- Monitoring protein-metal binding by 19 F NMR – a case study with the New Delhi metallo- β lactamase 1 † (2020) (2)
- Therapeutic Strategies that Target the HIF System (2008) (2)
- Accelerating Inhibitor Discovery for Multiple SARS-CoV-2 Targets with a Single, Sequence-Guided Deep Generative Framework (2022) (2)
- The role of sulphur in cephalosporin biosynthesis (1991) (2)
- Studies on enmetazobactam clarify mechanisms of widely used β-lactamase inhibitors (2022) (2)
- Crystal Structure of JMJD2A Complexed with Inhibitor (2012) (1)
- Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine (2023) (1)
- The Ring Expansion of Penams to Cephams: A Possible Biomimetic Process. (1989) (1)
- Unnatural cosubstrate-based rescue of enzyme activity in Refsum's disease resulting from a PAHX mutation (2000) (1)
- An Investigation of the N‐Arylsulfonylation of 2‐Azetidinones. (1997) (1)
- A small-molecule probe for monitoring binding to prolyl hydroxylase domain 2 by fluorescence polarisation. (2020) (1)
- Synthesis of a bicyclic oxo-γ-lactam from a simple caprolactam derivative (2017) (1)
- Unusually Stable Azetidinone Sulfenic Acids. (1998) (1)
- Journal of Medicinal Chemistry (2010) (1)
- Combined proteomic and biochemical analyses redefine the consensus sequence requirement for epidermal growth factor-like domain hydroxylation (2022) (1)
- 19F NMR studies on γ-butyrobetaine hydroxylase provide mechanistic insights and suggest a dual inhibition mode† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9cc06466d (2019) (1)
- A process for the preparation of clavulanic acid (1989) (1)
- A γ‐Lactam Analogue of the Penems Possessing Antibacterial Activity. (1989) (1)
- Broad‐range metalloprotease profiling in plants uncovers immunity provided by defence‐related metalloenzyme (2022) (1)
- Mutations to metabolic enzymes in cancer herald a need to unify genetics and biochemistry (2011) (1)
- What is the Catalytic Mechanism of Enzymatic Histone N-Methyl Arginine Demethylation and Can It be Influenced by an External Electric Field? (2021) (1)
- Penicillin biosynthesis: stereochemical dependence on mode of second ring closure (1989) (1)
- Exchange of valine-oxygen during the biosynthesis of δ-(L-α-aminoadipoyl)-L-cysteinyl-D-valine (1991) (1)
- Activity-based proteomics uncovers suppressed hydrolases and a neo-functionalised antibacterial enzyme at the plant-pathogen interface (2022) (1)
- Abstract 14: Preclinical evaluation of novel HIF-1α/P300 binding inhibitors (2018) (1)
- Exploring links between 2‐oxoglutarate‐dependent oxygenases and Alzheimer's disease (2022) (1)
- Recent physical and mechanistic studies on isopenicillin N synthase (1991) (1)
- WELO5 SMALL MOLECULE HALOGENASE WITH NI(II) AND 2-OXOGLUTARATE (2017) (1)
- Widespread hydroxylation of unstructured lysine-rich protein domains by JMJD6 (2022) (1)
- Microbiome-derived metabolites reproduce the mitochondrial dysfunction and decreased insulin sensitivity observed in type 2 diabetes (2020) (1)
- Can Second Coordination Sphere and Long-Range Interactions Modulate Hydrogen Atom Transfer in a Non-Heme Fe(II)-Dependent Histone Demethylase? (2022) (1)
- 5,5-Fused thiophene gamma-lactams as templates for serine protease inhibition. (2002) (1)
- Cover Picture: Evidence that Thienamycin Biosynthesis Proceeds via C‐5 Epimerization: ThnE Catalyzes the Formation of (2S,5S)‐trans‐Carboxymethylproline (ChemBioChem 2/2009) (2009) (1)
- Side Chain Specificity in the Enzymatic Synthesis of Penicillins. (1990) (1)
- Cover Picture: ESI-MS Studies on Prolyl Hydroxylase Domain 2 Reveal a New Metal Binding Site (ChemMedChem 4/2008) (2008) (1)
- Corrigendum to “Incorporation of oxygen into the succinate co‐product of iron(II) and 2‐oxoglutarate dependent oxygenases from bacteria, plants and humans (FEBS 29930)” [FEBS Lett. 579 (2005) 5170–5174] (2005) (1)
- ISOLATION AND PARTIAL CHARACTERISATION OF ACV (2006) (1)
- Anion-exchange chromatography mass spectrometry provides extensive coverage of primary metabolic pathways revealing altered metabolism in IDH1 mutant cells (2020) (1)
- Evaluation of 3-carbamoylpropanoic acid analogs as inhibitors of human hypoxia-inducible factor (HIF) prolyl hydroxylase domain enzymes (2021) (1)
- High level expression in Escherichia coli of a fungal gene under the control of strong promoters. (1990) (1)
- Synthesis and evaluation of delta-lactams (piperazones) as elastase inhibitors. (2003) (1)
- Amino Acid Synthesis via Ring Opening of N-Sulfonyl Aziridine-2- carboxylate Esters with Organometallic Reagents. (2010) (1)
- Substrate Specificity of Proline 4-Hydroxylase: Chemical and Enzymatic Synthesis of (2S,3R,4S)-Epoxyproline. (1994) (1)
- β-Sultams — A Novel Class of Serine Protease Inhibitors. (2001) (1)
- Delta-L-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase: isolation of L-cysteinyl-D-valine, a 'shunt' product, and implications for the order of peptide bond formation. (1995) (1)
- Antibiotics: Current Innovations and Future Trends. Edited by Sergio Sánchez and Arnold L. Demain (2015) (1)
- Use of (S)‐N‐tert‐Butoxycarbonylaziridine‐2‐carboxylate Derivatives for α‐Amino Acid Synthesis. (1996) (1)
- Hypoxic Response and Associated Diseases (2008) (1)
- Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5–RNA complexes (2022) (1)
- Kinetic and Structural Characterization of the First B3 Metallo-β-Lactamase with an Active-Site Glutamic Acid (2021) (1)
- Chapter 5:Chemical Biology of Histone Modifications (2010) (1)
- CRYSTAL STRUCTURE OF CLAVAMINATE SYNTHASE (2000) (1)
- Titelbild: Monitoring Conformational Changes in the NDM-1 Metallo-β-lactamase by 19F NMR Spectroscopy (Angew. Chem. 12/2014) (2014) (1)
- Enzymatic Synthesis of Monocyclic β-Lactams. (2002) (1)
- Isopenicillin N Synthase: A New Mode of Reactivity. (1993) (1)
- Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans (2022) (1)
- Monitoring protein-metal binding by 19F NMR – a case study with the New Delhi metallo-β-lactamase 1† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9md00416e (2020) (1)
- Synthesis of a Bicyclic γ‐Lactam Dipeptide Analogue. (2010) (1)
- Abstract P027: Preconditioning Cardiosphere-Derived Cells by Hypoxia and Prolyl Hydroxylase Inhibitors to Induce HIF-Related Metabolic Changes and C-Kit Expression (2011) (1)
- Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii. (2020) (1)
- Synthesis of a Bicyclic g-Lactam Dipeptide Analogue (1992) (1)
- Methyl 6-amino-6-oxohexanoate (2012) (1)
- Human histone demethylase KDM6B can catalyse sequential oxidations† †Electronic supplementary information (ESI) available: Procedures for synthesis of lysine analogues, solid phase peptide synthesis, MS and NMR activity assays. Characterisation of lysine analogues. See DOI: 10.1039/c8cc04057e (2018) (1)
- Factor inhibiting HIF can catalyze two asparaginyl hydroxylations in VNVN motifs of ankyrin fold proteins (2022) (1)
- Expanding the Repertoire of Low‐Molecular‐Weight Pentafluorosulfanyl‐Substituted Scaffolds (2022) (1)
- Metampicillin is a cyclic aminal produced by reaction of ampicillin with formaldehyde (2020) (1)
- Cleavage of the 5-amino-5-carboxy-2-oxapentanoyl side chain from enzymatically synthesised penicillins and cephalosporins (1995) (1)
- Substrate selectivity and inhibition of histidine JmjC hydroxylases MINA53 and NO66 (2023) (0)
- HIF prolyl hydroxylase 2 (PHD2/EGLN1) I280V/R281L/I292V variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216) (2016) (0)
- Spectroscopic studies reveal details of substrate-induced conformational changes distant from the active site in isopenicillin N synthase (2022) (0)
- Factor inhibiting HIF-1 Alpha in complex with Notch 1 fragment mouse notch (1930-1949) peptide (2010) (0)
- The Enzymatic Conversion of Exomethylene Cephalosporin C into Deacetyl Cephalosporin C and the Role of Molecular Oxygen in Cephalosporin C Biosynthesis. (1988) (0)
- Kinetic and inhibition studies on human Jumonji-C (JmjC) domain-containing protein 5 (2023) (0)
- isopenicillin N synthase in complex with ACV and Fe under anaerobic environment using FT-SSX methods (2020) (0)
- Novel 2‐Oxoglutarate Analogues Modulate the Epigenetic Activity of the Cancer‐related Human Enzyme Aspartate/Asparagine‐β‐Hydroxylase (2020) (0)
- Accelerating Inhibitor Discovery With A Deep Generative Foundation Model: Validation for SARS-CoV-2 Drug Targets (2022) (0)
- Human JMJD5 in complex with MN, NOG and RPS6 (129-144) (complex-1) (2018) (0)
- PORCINE PANCREATIC ELASTASE COMPLEXED WITH ACETYL-VAL-GLU-PRO-ILE-COOH (2001) (0)
- JMJD2A COMPLEXED WITH R-2-HYDROXYGLUTARATE AND HISTONE H3K36me3 PEPTIDE (30-41) (2011) (0)
- In Situ Inhibitor Synthesis and Screening by Fluorescence Polarization: An Efficient Approach for Accelerating Drug Discovery (2022) (0)
- Isolation of Dihydroclavaminic Acid (I), an Intermediate in the Biosynthesis of Clavulanic Acid (1991) (0)
- FACTOR INHIBITING HIF-1 ALPHA WITH 2-(3-hydroxyphenyl)-2-oxoacetic acid (2010) (0)
- Crystal structure of BRD9 bromodomain in complex with an indolizine ligand (2015) (0)
- Characterization of hypoxia inducible factor pathway in neuroprotection and neurorestoration following cerebral ischaemia (2013) (0)
- Activity-based probes trap early active intermediates during metacaspase activation (2022) (0)
- prolyl hydroxylase in complex with hypoxia inducible factor oxygen degradation domain peptide fragment from Trichoplax adhaerens (2018) (0)
- Clavulanic acid biosynthesis oligopeptide binding protein 2 (2009) (0)
- Ultra High Resolution Dickerson-Drew dodecamer B-DNA with 5-Hydroxymethyl-cytosine Modification (2013) (0)
- Human JMJD5 (Q275C) in complex with Mn(II), NOG and RPS6-A138C (129-144) (complex-2) (2018) (0)
- Clavulanic acid biosynthesis oligopeptide binding protein 2 complexed with bradykinin (2009) (0)
- University of Birmingham Expression of Idh1(R132H) in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis (0)
- Synthesis of δ-Lactam (2-Oxopiperazine) Inhibitors of Elastase. (2006) (0)
- Fluorine labeled IPNS S55C in complex with Fe and ACV under anaerobic conditions. (2021) (0)
- Alpha-ketoglutarate-dependent dioxygenase AlkB in complex with Fe and AKG after oxygen exposure using FT-SSX methods (2020) (0)
- [Table, MLS Numbers for probe analogs]. (2013) (0)
- Dioxygen Binding is Controlled by the Protein Environment in Non-Heme Fe(II) and 2-Oxoglutarate Oxygenases - A Study on Histone Demethylase PHF8 and an Ethylene Forming Enzyme. (2023) (0)
- Structures of human m6A RNA demethylases: FTO and ALKBH5 (2014) (0)
- Crystal Structure of VIM-2 metallo-beta-lactamase in complex with ML302F (2014) (0)
- Enantiospecific Synthesis of Dealanylalahopcin (I). (1990) (0)
- PORCINE PANCREATIC ELASTASE COMPLEXED WITH (3S, 4S)N-PARA-NITROBENZENESULPHONYL -3-ETHYL-4-(CARBOXYLIC ACID)PYRROLIDIN-2-ONE (1999) (0)
- Crystal structure of the metallo-beta-lactamase BCII (2014) (0)
- 4-Nitrobenzyl 5-oxo-2-(2-oxopiperidin-1-yl)-tetrahydrofuran-2-carboxylate (2007) (0)
- Syntheses of cis‐ and trans‐Pyrrolidine‐2,5‐dicarboxylic Acids. (1992) (0)
- CRYSTAL STRUCTURE OF CLAVAMINATE SYNTHASE IN COMPLEX WITH FE(II), 2-OXOGLUTARATE AND PROCLAVAMINIC ACID (2000) (0)
- Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with manganese, 3-fluoropyridine-2,4-dicarboxylic acid, and factor X substrate peptide fragment (39mer-4Ser) (2021) (0)
- Structure of the Na + /H + antiporter NhaA (2006) (0)
- FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH S-2-HYDROXYGLUTARATE (2011) (0)
- Novel multi-component approaches towards dimeric epidithiodiketopiperazines as anti-cancer agents (2011) (0)
- Crystal structure of JMJD2A complexed with 5-carboxy-8-hydroxyquinoline (2010) (0)
- Crystal Structure of Factor Inhibiting HIF-1 Alpha Complexed with Inhibitor (2011) (0)
- Modified DAOC/DACS enzymes (2005) (0)
- UPREGULATION OF HYPOXIA-INDUCIBLE FACTOR BY DI-METHYL OXALYL GLYCINE (DMOG) INCREASES NEOVASCULARIZATION WITHIN ISCHAEMIC MYOCARDIUM IN A PORCINE CORONARY OCCLUSION MODEL (2010) (0)
- Crystal Structure of Human ALKBH5 (2014) (0)
- HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with bicyclic FG2216 and RaPID-derived cyclic peptide 3C (14-mer) (2020) (0)
- Publisher Correction: JMJD5 is a human arginyl C-3 hydroxylase (2018) (0)
- Human phytanoyl-coa 2-hydroxylase in complex with iron and 2-oxoglutarate (2005) (0)
- Crystal structure of a hydroxylated HIF-1 alpha peptide bound to the pVHL/elongin-C/elongin-B complex (2002) (0)
- Snapshots of serine protease catalysis: (B) acyl-enzyme intermediate between porcine pancreatic elastase and human beta-casomorphin-7 jumped to pH 10 for 10 seconds (2001) (0)
- Crystal Structure of AlkB in complex with Fe(III) and N-Oxalyl-S-(3-nitrobenzyl)-L-cysteine (2012) (0)
- Factor inhibiting HIF-1 alpha in complex with N-(carboxycarbonyl)-D-phenylalanine (2005) (0)
- DELTA-R307A DEACETOXYCEPHALOSPORIN C SYNTHASE COMPLEXED WITH SUCCINATE AND CARBON DIOXIDE (2001) (0)
- Mouse Notch 1 Ankyrin Repeat Intracellular Domain (2008) (0)
- Factor inhibiting HIF-1 Alpha in complex with Notch 1 fragment mouse notch (1997-2016) peptide (2010) (0)
- Triflic Anhydride Mediated Synthesis of Oxazoles. (2009) (0)
- A promising cancer target: lead compounds blocking the HIF-1alpha/p300 interaction (2008) (0)
- Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins (2022) (0)
- HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Fe(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]alanine (2013) (0)
- Crystal structure of Tpa1p from Saccharomyces cerevisiae, termination and polyadenylation protein 1, in complex with pyridine-2,4-dicarboxylic acid (2,4-PDCA) (2014) (0)
- Toxoplasma activates host hypoxia inducible factor-1 by cytoplasmic trapping and lamp1-dependent lysosomal degradation of prolyl-hydroxylase 2 (2018) (0)
- FACTOR INHIBITING HIF-1 ALPHA WITH N,3-dihydroxybenzamide (2010) (0)
- HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with 2OG and RaPID-derived silent allosteric cyclic peptide 3C (14-mer) (2020) (0)
- Figure 8, Concentration response curve of compound 1 (CID: 459617) in MALDI-TOF-MS hit validation assay (2013) (0)
- Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with manganese, N-oxalyl-alpha-methylalanine, and factor X substrate peptide fragment(39mer-4Ser) (2021) (0)
- Figure 1, Previously reported inhibitors of JMJD histone demethylases (2013) (0)
- Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with manganese, 4,4-dimethyl-2-oxoglutarate, and factor X substrate peptide fragment(39mer-4Ser) (2021) (0)
- 60S ribosomal protein L8 histidine hydroxylase (NO66) in apo form (2014) (0)
- Structure of an oxygenase (2009) (0)
- Crystal structure of the 19F labelled OXA-48 (2019) (0)
- Structure of pVHL-elongin B-elongin C (VCB) in complex with hydroxylated-HIF-2alpha (523-542) in the C2221 form (2019) (0)
- Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with manganese, 2-oxoglutarate, and factor X substrate peptide fragment(39mer-4Ser) (2021) (0)
- Crystal structure of the metallo-beta-lactamase IMP-1 with D-captopril (2014) (0)
- Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9) (2013) (0)
- Crystal structure of AmpC from E. coli with Taniborbactam (VNRX-5133) (2020) (0)
- Ethyl 2-(2,3-dihyroxybenzamido) Acetate Induces Hypoxia Induced Factor-related Metabolic Changes in Cardiosphere-Derived Cells for Myocardial Infarction Therapy (2016) (0)
- Crystal Structure of JMJD2A complexed with inhibitor Pyridine-2,4- dicarboxylic acid (2007) (0)
- Faculty Opinions recommendation of A molecular switch and proton wire synchronize the active sites in thiamine enzymes. (2004) (0)
- Snapshots of serine protease catalysis: (A) acyl-enzyme intermediate between porcine pancreatic elastase and human beta-casomorphin-7 at pH 5 (2001) (0)
- HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with N-oxalylglycine (NOG) (2016) (0)
- Porcine pancreatic elastase complexed with Asn-Pro-Ile at pH 5.0 (2006) (0)
- FACTOR INHIBITING HIF-1 ALPHA WITH PYRIDINE 2,4 DICARBOXYLIC ACID (2009) (0)
- Crystal structure of Tpa1p from Saccharomyces cerevisiae, termination and polyadenylation protein 1, in complex with N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9) (2014) (0)
- Factor inhibiting HIF-1 alpha in complex with consensus ankyrin repeat domain-(d)allyl-GLY peptide (2015) (0)
- Crystal Structure of Phenylalanine Ammonia Lyase (PAL) from Petroselinum crispum bound to cinnamate (2019) (0)
- Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with citrate and rhein (RHN) (2013) (0)
- JMJD2A COMPLEXED WITH R-2-HYDROXYGLUTARATE (2011) (0)
- Kinetic investigations on the reaction of a 2-oxoglutarate dependent histone demethylase with oxygen (2012) (0)
- Isopenicillin N synthase structure in complex with Fe and IPN exposed to dioxygen. (2021) (0)
- Abstract LB-302: PTP1B regulates the Moyamoya disease-associated E3 ligase, RNF213 and cellular dioxygenase activity to allow breast tumor survival in hypoxia (2015) (0)
- Porcine pancreatic elastase complexed with beta-casomorphin-7 and Arg-Phe at pH 5.0 (50 min soak) (2006) (0)
- Crystal structure of AmpC from E. coli with Cyclic Boronate 3 (CB3 / APC308) (2020) (0)
- Figure 13, Immunofluorescent staining for the HSV DNA replication protein UL29 (2013) (0)
- Trifluoromethyl Alcohol and Ketone Inhibitors of Metallo-β- lactamases. (1997) (0)
- Studies on deacetoxycephalosporin C synthase (1999) (0)
- TCT-441 Enhanced Endothelial Tubule Formation in Response to Proly-Hydroxylase Inhibitor FG-2216: A Step Towards Therapeutic Angiogenesis in Chronic Total Occlusions (2012) (0)
- ANTHOCYANIDIN SYNTHASE FROM ARABIDOPSIS THALIANA COMPLEXED with naringenin (2006) (0)
- Oxygen Consumption Rate (OCR), Extracellular Acidification Rate (ECAR) of C2C12, and wild-type and FTO knockout MEFs treated with 1 μM IOX3 or an equivalent amount of vehicle control for 16 hours. (2015) (0)
- Crystal Structure of AlkB in complex with Fe(III) and N-Oxalyl-S-(2-napthalenemethyl)-L-cysteine (2012) (0)
- "From one seed a whole handful": homologous proteins as seeds in crystallisation (2014) (0)
- Halofantrine in the treatment of multidrug-resistant malaria continued. (2016) (0)
- Microsoft Word-UTY manuscript JBC final changes marked RJH corrected.docx (2014) (0)
- Human JMJD5 in complex with MN and 2OG. (2018) (0)
- Table 3, Variations to compound 1 (2013) (0)
- Rhodothermus marinus YCFD-like ribosomal protein L16 Arginyl hydroxylase (2014) (0)
- Porcine pancreatic elastase complexed with beta-casomorphin-7 and Lys-Ser at pH 5 and immersed in pH 9 buffer for 30 seconds (2006) (0)
- Structural studies on the mechanism of 2-oxoglutarate oxygenases (2000) (0)
- Crystal Structure of CTX-M-15 with 1C (2017) (0)
- Structural and mechanistic studies on a cephalosporin esterase from the clavulanic acid biosynthesis pathway (2011) (0)
- Structural, functional and evolutionary studies on prolyl-hydroxylases (2014) (0)
- Crystal structure of JMJD2A complexed with bipyridyl inhibitor (2011) (0)
- Anthocyanidin synthase from Arabidopsis thaliana (selenomethionine substituted) (2002) (0)
- Expression of Idh1R132H in the murine subventricular zone stem cell niche recapitulates early gliomagenesis (2016) (0)
- Studies on enzymes mechanism and selectivity using synthetic substrate analogues (2012) (0)
- Publisher Correction: JMJD5 is a human arginyl C-3 hydroxylase (2018) (0)
- University of Birmingham Mutation analysis of HIF-prolylhydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility (2010) (0)
- VIM-2 metallo-beta-lactamase in complex with 3-oxo-2-phenylisoindoline-4-carboxylic acid (compound 30) (2017) (0)
- Lysine-N,N-Dimethylated HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with BB-287 (2020) (0)
- Factor Inhibiting HIF (FIH) in complex with zinc, NOG and ASPP2 (970-992) (2019) (0)
- The catalytic domains of all human KDM5 JmjC demethylases catalyse N‐methyl arginine demethylation (2023) (0)
- Crystal structure of Tpa1p from Saccharomyces cerevisiae, termination and polyadenylation protein 1, in complex with N-oxalylglycine (NOG) (2014) (0)
- Publisher Correction: Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19 (2021) (0)
- Arginine hydroxylase VioC in complex with Arg, 2OG and Fe under anaerobic environment using FT-SSX methods (2020) (0)
- Differentiating Inhibition Selectivity and Binding Affinity of Isocitrate Dehydrogenase 1 Variant Inhibitors (2023) (0)
- Crystal structure of a Pseudomonas putida prolyl-4-hydroxylase (P4H) in complex with elongation factor Tu (EF-Tu) (2014) (0)
- HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with a Spiro[4.5]decanone inhibitor (JPHM-2-167) (2020) (0)
- Controlling the Substrate Selectivity of Deacetoxycephalosporin/ (2004) (0)
- Dynamical nonequilibrium molecular dynamics simulations identify allosteric sites and positions associated with drug resistance in the SARS-CoV-2 main protease (2022) (0)
- 60S ribosomal protein L27A histidine hydroxylase (MINA53 Y209C) in complex with MN(II), 2-oxoglutarate (2OG) and 60S ribosomal protein L27A (RPL27A G37C) peptide fragment (2014) (0)
- Crystal structure of Fe(II)- and 2OG-dependent oxygenase JMJD6 (aa 1-403) in complex with Mn(II) and NOG (2018) (0)
- Erratum. Adipocyte Pseudohypoxia Suppresses Lipolysis and Facilitates Benign Adipose Tissue Expansion. Diabetes 2015;64:733–745 (2021) (0)
- Engineered oxidase reveals steric control of oxygen (2014) (0)
- Figure 18, Co-crystallization of compound 1 with JMJD2A (PDB: 3NJY) (2013) (0)
- γ-Lactam Formation from Tripeptides with Isopenicillin N Synthase. (1989) (0)
- Refsum's disease: a peroxisomal disorder affecting alpha-oxidation of phytanic acid: a mini-review (2002) (0)
- Improved Synthesis of 5-Hydroxymethyl-2′-deoxycytidine Phosphoramidite Using a 2′-Deoxyuridine to 2′-Deoxycytidine Conversion Without Temporary Protecting Groups. (2011) (0)
- Mechanistic studies on 2-oxoglutarate dependent oxygenases (2012) (0)
- Correction to “Structure-Based in Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library” (2019) (0)
- Biochemical and Structural Insights into FIH‐Catalysed Hydroxylation of Transient Receptor Potential Ankyrin Repeat Domains (2022) (0)
- Expression of protocadherinX/Y in the developing human brain (2004) (0)
- JMJD5 is a human arginyl C-3 hydroxylase (2018) (0)
- HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Mn(II) and 2-(4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid (2013) (0)
- CRYSTAL STRUCTURE OF E. COLI PBP5 WITH 2C (2016) (0)
- Scheme 1, Synthetic route for analogs containing 5-COOH (2013) (0)
- Crystal structure of the metallo-beta-lactamase VIM-5 (2015) (0)
- PHD2:Fe:UN9:partial HIF1-alpha substrate complex (2009) (0)
- S-nitrosylated PHD2 (GSNO soaked) in complex with Zn(II) and UN9 (2010) (0)
- Crystal structure of the OXA10 with 1C (2016) (0)
- VIM-2 metallo-beta-lactamase in complex with 2-(3-fluoro-4-hydroxyphenyl)-3-oxoisoindoline-4-carboxylic acid (compound 35) (2017) (0)
- Crystal structure of human phytanoyl-COA dioxygenase phyhd1 2-oxoglutarate and iron complex (2010) (0)
- HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Vadadustat (2017) (0)
- Pseudomonas expression of an oxygen sensing prolyl hydroxylase homologue regulates neutrophil host responses and in vitro in vivo [ version 1 ; referees : awaiting peer review ] (2017) (0)
- Faculty Opinions recommendation of Drugs, their targets and the nature and number of drug targets. (2006) (0)
- Aspartyl/Asparaginyl beta-hydroxylase (AspH) H725A in complex with Factor X peptide fragment (39mer-4Ser) (2021) (0)
- Factor Inhibiting HIF (FIH) in complex with zinc and Molidustat (2017) (0)
- Structure of VIM-2 metallo-beta-lactamase with hydrolysed Faropenem imine product (2021) (0)
- Crystal structure of AlkB in complex with Fe(III) and 2-(3-hydroxypicolinomido)acetic acid (2012) (0)
- Crystal structure of AmpC from E. coli with cyclic boronate 2 (2020) (0)
- HIF-prolyl-hydroxylase 2 clinical inhibitor complex structure and XChem fragment-based screen obtained with succinate co-product used as a crystallisation tool (2021) (0)
- Cephalosporin Biosynthesis: A Branched Pathway Sensitive to an Isotope Effect. (1992) (0)
- JmjC domain-containing protein 5 (JMJD5) in complex with Mn and pyridine-2,4-dicarboxylic acid (2,4-PDCA) (2019) (0)
- Anthocyanidin synthase from Arabidopsis thaliana complexed with trans-dihydroquercetin (2002) (0)
- Isopenicillin N synthase in complex with Fe, O2 and ACV under cryo conditions. (2021) (0)
- Ethylene Forming Enzyme from Pseudomonas syringae pv. phaseolicola - I222 crystal form in complex with manganese and 2-oxoglutarate (2017) (0)
- Tumour suppression by a protein hydroxylase (2016) (0)
- Factor Inhibiting HIF (FIH) in complex with zinc, NOG and ASPP1(932-954) (2019) (0)
- Figure 6, Plate Z' trend for the JMJD2E primary qHTS (2013) (0)
- Crystal structure of Pseudomonas putida elongation factor Tu (EF-Tu) (2014) (0)
- Crystal structure of human OGFOD1, 2-oxoglutarate and iron-dependent oxygenase domain containing 1, in complex with pyridine-2,4-dicarboxylic acid (2,4-PDCA) (2014) (0)
- HIF inhibitors for use in the treatment of anemia hydroxylase. (2003) (0)
- Crystal structure of the catalytic domain of PHD finger protein 8 (2009) (0)
- Human JMJD5 in its apo form. (2018) (0)
- 60S ribosomal protein L8 histidine hydroxylase (NO66) in complex with Mn(II) and N-oxalylglycine (NOG) (2014) (0)
- Crystal structure of JMJD2A complexed with histone H3 peptide monomethylated at Lys9 (2007) (0)
- Jmjd4b, a putative nuclear hydroxylase is essential for embryogenesis, tissue homeostasis, and immunity (2006) (0)
- A ¨-lactam analogue of the penems possessing antibacterial activity (1986) (0)
- Cover Picture: Monitoring Conformational Changes in the NDM‐1 Metallo‐β‐lactamase by 19F NMR Spectroscopy (Angew. Chem. Int. Ed. 12/2014) (2014) (0)
- HIF prolyl hydroxylase 2 (PHD2/EGLN1) G294E variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216) (2016) (0)
- Modulation of the hypoxic response in cancer; inhibition of the HIF-1α/p300 protein-protein interaction (2014) (0)
- New deacetoxy/deacetylcephalosporin C synthase (DAOC/DACS) enzyme modified to reduce the hydroxylation activity of the enzyme, useful for improving ring-expanding activity (2005) (0)
- FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH TANKYRASE-2 (TNKS2) FRAGMENT PEPTIDE (21-MER) (2011) (0)
- inhibition by prolyl hydroxylase domain inhibitors Complement C 1 q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target that stabilize hypoxia-inducible factor (2017) (0)
- Antibiotics as food for bacteria (2018) (0)
- CRYSTAL STRUCTURE OF CLAVAMINATE SYNTHASE IN COMPLEX WITH FE(II) AND 2-OXOGLUTARATE (2000) (0)
- Comparative study of the analysis of seized samples by GC-MS, 1H NMR and FT-IR spectroscopy within a Night-Time Economy (NTE) setting. (2022) (0)
- Figure 16, Probe development/medicinal chemistry optimization flowchart (2013) (0)
- Natural and synthetic 2-oxoglutarate derivatives are substrates for oncogenic variants of human isocitrate dehydrogenase 1 and 2 (2023) (0)
- Formaldehyde reacts with N-terminal proline residues to give bicyclic aminals (2023) (0)
- Factor Inhibiting HIF (FIH) in complex with zinc, NOG and TRPV3 (220-246) (2019) (0)
- Correction to “Structural Basis of Metallo-β-lactamase Inhibition by N-Sulfamoylpyrrole-2-carboxylates” (2021) (0)
- Inhibiteurs d’histone lysine déméthylase (2009) (0)
- Figure 11, [(A) Viral IE (ICP4, ICP27,...]. (2013) (0)
- Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with manganese, 5-fluoropyridine-2,4-dicarboxylic acid, and factor X substrate peptide fragment (39mer-4Ser) (2021) (0)
- Porcine pancreatic elastase complexed with beta-casomorphin-7 and Lys-Ala-NH2 at pH 5.0 (2006) (0)
- Publisher Correction: The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases (2018) (0)
- Factor Inhibiting HIF (FIH) in complex with zinc, NOG and TRPV3 (229-255) (2019) (0)
- mono-Zinc VIM-5 metallo-beta-lactamase in complex with (1-chloro-4-hydroxyisoquinoline-3-carbonyl)-D-tryptophan (Compound 1) (2017) (0)
- Crystal structure of 2OG oxygenase JMJD6 (aa 1-343) in complex with Fe(II) and 2OG (2019) (0)
- Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with manganese and 2-oxoglutarate (2021) (0)
- Applications of 19F-NMR to study protein-ligand interactions and protein conformational changes in solution (2015) (0)
- DEACETOXYCEPHALOSPORIN C SYNTHASE COMPLEXED WITH FE(II) (1999) (0)
- Crystal Structure of AlkB in complex with 5-carboxy-8-hydroxyquinoline (IOX1) (2013) (0)
- Biomimetic Catalysts Human Oxygenase Variants Employing a Single Protein Fe Ligand Are Catalytically Active (2021) (0)
- YcfDRM is a thermophilic oxygen-dependent ribosomal protein uL16 oxygenase (2018) (0)
- Histone Lysine demethylase JMJD2A in complex with T11C peptide substrate crosslinked to N-oxalyl-D-cysteine (2012) (0)
- Crystal structure of the metallo-beta-lactamase VIM-2 with ML302F (2014) (0)
- Factor Inhibiting HIF-1 alpha (2002) (0)
- Phd 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses (2017) (0)
- Human gamma-butyrobetaine dioxygenase (BBOX1) in complex with Ni(II) and N-(3-hydroxypicolinoyl)-S-(pyridin-2-ylmethyl)-L-cysteine (AR692B) (2014) (0)
- Crystal structure of NDM-1 with VNRX-5133 (2019) (0)
- HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with CCT6, a GSK1278863-related compound (2017) (0)
- JmjC domain-containing protein 5 (JMJD5) in complex with Mn and R-2-hydroxyglutarate (2019) (0)
- Faculty Opinions recommendation of Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis. (2006) (0)
- Carboxyethylarginine synthase from Streptomyces clavuligerus: putative reaction intermediate complex (2007) (0)
- Crystal Structure of human PHF8 in complex with Daminozide (2012) (0)
- Nanomechanics of Ankyrin-R Repeats Probed by AFM and SMD Simulations (2010) (0)
- Studies on the Reactivity of Azetidin-2-ones in Phosphate Buffer. (1998) (0)
- NAR Breakthrough Article Structure of human RNA N6-methyladenine (2013) (0)
- Porcine pancreatic elastase complexed with beta-casomorphin-7 and Arg-Phe at pH 5.0 (50 min soak) and immersed in pH 9 buffer for 30 seconds (2006) (0)
- HIF prolyl hydroxylase 2 (PHD2-R281C/P317C/R396T) cross-linked to HIF-1alpha NODD-L397C/D412C and N-oxalylglycine (NOG) (complex-3) (2016) (0)
- Adult presentation of hypophosphatasia due to a novel compound heterozygous Tissue Nonspecific Alkaline Phosphatase (ALPL) mutation (2016) (0)
- Crystal structure of human OGFOD1, 2-oxoglutarate and iron-dependent oxygenase domain containing 1, in complex with N-oxalylglycine (NOG) (2014) (0)
- 60S ribosomal protein L8 histidine hydroxylase (NO66 L299C/C300S) in complex with Mn(II), N-oxalylglycine (NOG) and 60S ribosomal protein L8 (RPL8 G220C) peptide fragment (complex-2) (2014) (0)
- DELTA-R306 DEACETOXYCEPHALOSPORIN C SYNTHASE COMPLEXED WITH IRON AND 2-OXOGLUTARATE. (2001) (0)
- Biochemical and structural analysis of the Clavulanic acid dehydeogenase (CAD) from Streptomyces clavuligerus (2007) (0)
- Carboxyethylarginine synthase from Streptomyces clavuligerus: 5-guanidinovaleric acid complex (2007) (0)
- Epigenetic modifiers reduce proliferation of human neuroendocrine tumour cell lines (2013) (0)
- Crystal Structure of Clavaminate Synthase with Nitric Oxide (2003) (0)
- Chemical probes for bromodomains outside the BET family (2013) (0)
- Crystal Structure of VIM-2 metallo-beta-lactamase in complex with ML302 and ML302F (2014) (0)
- Porcine pancreatic elastase complexed with Asn-Pro-Ile and Ala-Ala at pH 5.0 (2006) (0)
- Table 1, LSD1 histone demethylaseassay protocol (2013) (0)
- Engineering carboxymethylproline synthases towards the biosynthetic productions of carbapenem antibiotics (2013) (0)
- Prolyl Hydroxylase (PHD) involved in hypoxia sensing by Dictyostelium discoideum (2020) (0)
- PHD2:Mn:NOG:HIF1-alpha substrate complex (2009) (0)
- Frontispiece: Cation–π Interactions Contribute to Substrate Recognition in γ‐Butyrobetaine Hydroxylase Catalysis (2016) (0)
- PROCLAVAMINATE AMIDINO HYDROLASE FROM STREPTOMYCES CLAVULIGERUS (2002) (0)
- Asn-hydroxylation stabilises the ankyrin repeat domain fold (2008) (0)
- Synthesis and Evaluation of δ‐Lactams (Piperazones) as Elastase Inhibitors. (2003) (0)
- JMJD2A COMPLEXED WITH NI(II), NOG AND HISTONE H3K27me3 PEPTIDE (25-29) ARK(me3)SA (2014) (0)
- Metallo-β-lactamase-mediated antimicrobial resistance and progress in inhibitor discovery. (2023) (0)
- Magnetic resonance spectroscopy for 2-hydroxyglutarate identifies IDH mutant gliomas (2013) (0)
- CCDC 872411: Experimental Crystal Structure Determination (2012) (0)
- CRYSTAL STRUCTURE OF HUMAN GAMMA-BUTYROBETAINE,2-OXOGLUTARATE IN COMPLEX WITH 449, A NOVEL SUBSTRATE (2014) (0)
- Structure of a novel N-acyl-enzyme intermediate of an N-terminal nucleophile (Ntn) hydrolase, OAT2 (2008) (0)
- Crystal structure of AmpC from E.coli with Relebactam (MK-7655) (2020) (0)
- Factor Inhibiting HIF (FIH) in complex with zinc and GSK128863 (2017) (0)
- The Ring Opening of Aziridine-2-carboxylate Esters with Organometallic Reagents. (1990) (0)
- Comparison of Verona Integron-Borne Metallo- (cid:2) -Lactamase (VIM) Variants Reveals Differences in Stability and Inhibition Profiles (2016) (0)
- Tautomer-Specific Deacylation and Ω-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 β-Lactamase (2022) (0)
- Structure of the acyl-enzyme complex of an N-terminal nucleophile (Ntn) hydrolase, OAT2 (2008) (0)
- DNA Modification under Mild Conditions by Suzuki—Miyaura Cross‐Coupling for the Generation of Functional Probes. (2014) (0)
- FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH R-2-HYDROXYGLUTARATE (2011) (0)
- Artemis (DCLRE1C, SNM1C): A Target Enabling Package (2021) (0)
- Aspartyl/Asparaginyl beta-hydroxylase (AspH) H679A in the apo form (2020) (0)
- VIM-2 metallo-beta-lactamase in complex with 2-(2-chloro-6-fluorobenzyl)-3-oxoisoindoline-4-carboxylic acid (compound 16) (2017) (0)
- Factor Inhibiting HIF (FIH) in complex with zinc, NOG and TRPA1 (313-339) (2019) (0)
- Room temperature XFEL Isopenicillin N synthase structure in complex with Fe and ACV after exposure to dioxygen for 400ms. (2021) (0)
- Kinetic and mechanistic studies of oxygen sensing Fe(II)/2-oxoglutarate dependent oxygenases (2014) (0)
- Anthocyanidin synthase from Arabidopsis thaliana complexed with trans-dihydroquercetin (with 30 min exposure to O2) (2002) (0)
- Human JMJD7 in complex with Mn and 2OG in the P21212 form (2018) (0)
- Porcine pancreatic elastase complexed with N-acetyl-NPI and Ala-Ala at pH 5.0 (2006) (0)
- Syntheses of (6S,7S)‐ and (6S,7R)‐Deacetoxycephalosporanic Acids from 6‐Aminopenicillanic Acid. (1996) (0)
- Unnatural cosubstrate-based rescue of enzyme in Refsum's disease resulting from mutations in R275 of phytanoyl-CoA 2-hydroxylase (2000) (0)
- carboxymethylproline synthase (CarB) from pectobacterium carotovora, complexed with acetyl CoA and bicine (2005) (0)
- Ethylene Forming Enzyme from Pseudomonas syringae pv. phaseolicola - I222 crystal form (2017) (0)
- Arginine hydroxylase VioC in complex with (3S)-OH-Arg, succinate and Fe after oxygen exposure using FT-SSX methods (2020) (0)
- Time-resolved serial femtosecond crystallography of the early intermediates in the isopenicillin N synthase reaction with ACV and O2 (2020) (0)
- FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH CONSENSUS ANKYRIN REPEAT DOMAIN-LEU PEPTIDE (20-MER) (2013) (0)
- Chemoenzymatic Synthesis of Bicyclic γ‐Lactams Using Clavaminic Acid Synthase. (1997) (0)
- Crystal structure of the metallo-beta-lactamase BCII with D-captopril (2014) (0)
- Snapshots of serine protease catalysis: (C) acyl-enzyme intermediate between porcine pancreatic elastase and human beta-casomorphin-7 jumped to pH 9 for 1 minute (2001) (0)
- Room temperature XFEL Isopenicillin N synthase structure in complex with Fe and ACV under anaerobic conditions. (2021) (0)
- Single-Molecule Atomic-Force Spectroscopy Captures a Novel Class of Molecular Nanosprings with Robust Stepwise Refolding Properties (2010) (0)
- ISOPENICILLIN N SYNTHASE aminoadipoyl-cysteinyl-aminobutyrate-FE-NO COMPLEX (2004) (0)
- Interaction of Avibactam with Class B Metallo- (cid:2) -Lactamases (2016) (0)
- The Reaction of TMS‐CF3 with Amino Acid Derived Ring‐Templates: Studies with Oxazin‐2‐ones and Oxazolidin‐5‐ones. (2000) (0)
- Ethylene Forming Enzyme from Pseudomonas syringae pv. phaseolicola - P1 ultra-high resolution crystal form in complex with iron, N-oxalylglycine and arginine (2017) (0)
- Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with 5-carboxy-8-hydroxyquinoline (IOX1) (2013) (0)
- FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH DAMINOZIDE (2012) (0)
- Symmetry breaking by enzyme-catalyzed epoxide hydrolysis (2018) (0)
- The Synthesis of Potential γ-Lactam Antibiotics Containing a Cycloserine Nucleus. (1991) (0)
- Crystallographic studies on 2-oxoglutarate dependent oxygenases (2014) (0)
- HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9) (2013) (0)
- X-Ray structure of E. coli ycfD (2014) (0)
- SNM1A (DCLRE1A) is required for the efficient repair of complex DNA breaks in human cells (2022) (0)
- Figure 15, MRC-5 cells were treated with DMSO or 50 mM ML324 for 3 hr, followed by infection with hCMV (0.1 pfu/cell) for 5 hr (2013) (0)
- FACTOR INHIBITING HIF-1 ALPHA with fumarate (2006) (0)
- Book Reviews: : Comprehensive Natural Products Chemistry. Volumes 1 to 8. (1999) (0)
- Front Cover: What Is the Catalytic Mechanism of Enzymatic Histone N‐Methyl Arginine Demethylation and Can It Be Influenced by an External Electric Field? (Chem. Eur. J. 46/2021) (2021) (0)
- Dioxygen Binding Is Controlled by the Protein Environment in Non-heme FeII and 2-Oxoglutarate Oxygenases: A Study on Histone Demethylase PHF8 and an Ethylene-Forming Enzyme. (2023) (0)
- Alpha-ketoglutarate-dependent dioxygenase AlkB in complex with Fe, AKG and methylated DNA under anaerobic environment using FT-SSX methods (2020) (0)
- Faculty Opinions recommendation of Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy. (2010) (0)
- Human Ethylmalonic Encephalopathy Protein 1 (hETHE1) (2014) (0)
- Isopenicillin N synthase in complex with Fe, the oxygen surrogate NO and ACV. (2021) (0)
- Adipocyte-specific deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality (2021) (0)
- ULTRA HIGH RESOLUTION DICKERSON-DREW DODECAMER B-DNA (2013) (0)
- Crystal structure of LdtMt2 from Mycobacterium tuberculosis (2019) (0)
- Backbone and Partial Side-Chain Chemical Shift Assignments and DynamicsMeasurements for The Catalytic Domain of Human Prolyl Hydroxylase Domain 2 (PHD2) With Zn(II) and 2-Oxoglutarate (2OG) (2016) (0)
- JMJD2A COMPLEXED WITH DAMINOZIDE (2012) (0)
- Probing the Charge and Conformational Requirements of JmjC Demethylases (2017) (0)
- Crystal structure of a Pseudomonas putida prolyl-4-hydroxylase (P4H) (2014) (0)
- HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with monocyclic BB-328 (2020) (0)
- A dominant mutation in the obesity susceptibility gene FTO results in reduced fat mass with enhanced lipid and carbohydrate metabolism (2009) (0)
- ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (MANGANESE COMPLEX) (1998) (0)
- Bromodomain inhibitors reduce proliferation and increase apoptosis of human neuroendocrine tumour cells (2014) (0)
- Crystal structure of AmpC from E.coli with Nacubactam (OP0595) (2020) (0)
- Rhodothermus marinus YCFD-like ribosomal protein L16 Arginyl hydroxylase in complex substrate fragment (2014) (0)
- Characterization of Rm3 Metallo- β -Lactamase Structural and Biochemical Characterization of Rm3, a SubClass B3 Metallo- 1 β -Lactamase Identified from a Functional Metagenomic Study (2016) (0)
- In vitro and in vivo Activity of ML302F a Novel Thioenolate Metallo-β-lactamase Inhibitor (2015) (0)
- Interactions of hydrolyzed β-lactams with the L1 metallo-β-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products (2023) (0)
- VIM-2 in Complex with Biapenem Imine and Enamine Hydrolysis Products (2021) (0)
- Crystal structures of 2OG oxygenases involved in ribosomal protein hydroxylation (2014) (0)
- Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with manganese and 3-methyl-2-oxoglutarate (2021) (0)
- Synthesis of Potential β-Turn Bicyclic Dipeptide Mimetics. (1993) (0)
- JMJD7 IN COMPLEX WITH MN AND 2OG IN THE H32 FORM (2018) (0)
- Expression in Escherichia coli of a Clavaminic Acid Synthase Isozyme: A Trifunctional Oxygenase Involved in Clavulanic Acid Biosynthesis. (1994) (0)
- Faculty Opinions recommendation of Expanding role of the jumonji C domain as an RNA hydroxylase. (2010) (0)
- Ornithine Acetyltransferase (ORF6 Gene Product - Clavulanic Acid Biosynthesis) from Streptomyces clavuligerus (SeMet structure) (2004) (0)
- Hif hydroxylase inhibitors for anemia treatment (2003) (0)
- Studies of JMJD4-catalyzed oxidative modifications of eukaryotic release factor 1 (2015) (0)
- Corrigendum: A substrate analogue study on clavaminic acid synthesis: Possible clues to the biosynthetic origin of proclavamic acid (Journal of the Chemical Society, Chemical Communications (1993) (500)) (1993) (0)
- Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins. (2022) (0)
- Figure 12, [(A) MRC-5 cells were treated...]. (2013) (0)
- Alteration of the 2-Oxoacid Cosubstrate Selectivity in Deacetoxycephalosporin C Synthase: The Role of Arginine-258 (2001) (0)
- 3-Methoxy-3-oxopropanaminium chloride (2012) (0)
- FACTOR INHIBITING HIF-1 ALPHA with succinate (2006) (0)
- Dosages de mina53 (2006) (0)
- STUDIES ON SIDE CHAIN INTERACTIONS DURING THE ISOPENICILLIN N SYNTHASE CATALYSED BIOSYNTHESIS OF PENICILLINS (1997) (0)
- Stereospecific Synthesis of Dealanylalahopcin. (1990) (0)
- Figure 17, SAR summary of JMD2E probe, ML324 (2013) (0)
- JMJD2A COMPLEXED WITH NI(II), NOG AND HISTONE H3K27me3 PEPTIDE (16-35) (2014) (0)
- HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with MD-253 (2020) (0)
- VIM-2 metallo-beta-lactamase in complex with (S)-1-allyl-2-(3-methoxyphenyl)-3-oxoisoindoline-4-carboxylic acid (compound 42) (2017) (0)
- VIM-2 Metallo Beta Lactamase in complex with 3-(mercaptomethyl)-[1,1'-biphenyl]-4-carboxylic acid (2017) (0)
- The crystal structure of JMJD2A complexed with Ni and N-oxalylglycine (2007) (0)
- Carboxyethylarginine synthase from Streptomyces clavuligerus (2003) (0)
- VIM-2 metallo-beta-lactamase in complex with 3-oxo-2-(3-(trifluoromethyl)phenyl)isoindoline-4-carboxylic acid (compound 17) (2017) (0)
- Reaction of Ruppert′s Reagent (TMS‐CF3) with Oxazolidinones: Synthesis of Protected α‐Amino Trifluoromethylketones. (1996) (0)
- Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with N-[(3-hydroxypyridin-2-yl)carbonyl]glycine (MD6) (2013) (0)
- The Mechanism of ACV Synthetase (1998) (0)
- PORCINE PANCREATIC ELASTASE COMPLEXED WITH (3S, 4R)-1-TOLUENESULPHONYL-3-ETHYL-AZETIDIN-2-ONE-4-CARBOXYLIC ACID (1999) (0)
- STRUCTURE OF JMJD2A COMPLEXED WITH INHIBITOR 10A (2010) (0)
- Crystal structure of AmpC from E.coli with Zidebactam (WCK 5107) (2020) (0)
- NAR Breakthrough Structure of human RNA N 6 -methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation (2014) (0)
- Human JMJD5 in complex with Mn(II) and Succinate. (2018) (0)
- Revised Structures for Tue 1718B (Ia) and Valclavam (Ib). (1994) (0)
- Roles of oxygenases in nucleic acid modification (2011) (0)
- Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors (2020) (0)
- Synthesis of a Novel Bicyclic γ-Lactam Analogue of the 1-Oxapenams. (1990) (0)
- FACTOR INHIBITING HIF (FIH) Q239H MUTANT IN COMPLEX WITH ZN(II), NOG AND ASP-SUBSTRATE PEPTIDE (20-MER) (2010) (0)
- Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans (2022) (0)
- Cover Picture: Chromophore‐Linked Substrate (CLS405): Probing Metallo‐β‐Lactamase Activity and Inhibition (ChemMedChem 12/2013) (2013) (0)
- 8-Hydroxyquinoline-5-Carboxylic Acid is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation (2013) (0)
- Human metallo beta lactamase domain containing protein 1 (hMBLAC1) (2016) (0)
- Crystal structure of an oxygenase in complex with inhibitor cco010 (2015) (0)
- Figure 14, [(A) Viral yields from HSV-1...]. (2013) (0)
- carboxymethylproline synthase (CarB) from pectobacterium carotovora, apo enzyme (2005) (0)
- CRYSTAL STRUCTURE OF CLAVAMINATE SYNTHASE IN COMPLEX WITH FE(II), 2-OXOGLUTARATE AND N-ALPHA-L-ACETYL ARGININE (2000) (0)
- Crystal structure of the human 2-oxoglutarate oxygenase LOC390245 (2009) (0)
- VIM-2 metallo-beta-lactamase in complex with ((S)-3-mercapto-2-methylpropanoyl)-D-tryptophan (Compound 3) (2017) (0)
- NADP(H)-dependent biocatalysis without adding NADP(H) (2022) (0)
- Crystal structure of the metallo-beta-lactamase VIM-2 with D-captopril (2014) (0)
- JMJD2A/ KDM4A COMPLEXED WITH NI(II), NOG AND Macrocyclic PEPTIDE Inhibitor CP2_R6Kme3 (13-mer) (2017) (0)
- HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with N-oxalylglycine (NOG) and a RaPID-derived silent allosteric cyclic peptide 3C (14-mer) (2020) (0)
- PENICILLIN-BINDING PROTEIN 1B (PBP-1B) IN COMPLEX WITH AN ALKYL BORONATE (A01) (2011) (0)
- Structure of Metallo-beta-lactamase (2015) (0)
- Structural and mechanistic studies on prolyl hydroxylases (2008) (0)
- HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) in complex with N-Oxalyl Glycine (NOG), HIF-1ALPHA CODD (556-574) and a RaPID-derived cyclic peptide 3C (14-mer) (2020) (0)
- HIF prolyl hydroxylase 2 (PHD2/EGLN1) in complex with 6-(5-oxo-4-(1H- 1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinic acid (2015) (0)
- 5,5‐Fused Thiophene γ‐Lactams as Templates for Serine Protease Inhibition. (2002) (0)
- Reactions of a Glycidyl Radical Equivalent with 2-Functionalized Allylstannanes. (1989) (0)
- Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with pyridine-2,4-dicarboxylate (2,4-PDCA) (2013) (0)
- Crystal structure of AmpC from E.coli (2020) (0)
- Design and synthesis of small molecule chemical probes for bromodomain-containing proteins. (2014) (0)
- The Stereospecific Synthesis of Alahopcin. (1991) (0)
- Faculty Opinions recommendation of SLR-2 and JMJC-1 regulate an evolutionarily conserved stress-response network. (2010) (0)
- JMJD2A/ KDM4A COMPLEXED WITH NI(II) AND Macrocyclic PEPTIDE Inhibitor CP2 (13-mer) (2017) (0)
- Porcine pancreatic elastase complexed with human beta-casomorphin-7 (1999) (0)
- JMJD2A COMPLEXED WITH NI(II), NOG AND HISTONE H4(1-15)R3me2s PEPTIDE (2016) (0)
- Optimized Synthesis of Indole Carboxylate Metallo-β-Lactamase Inhibitor EBL-3183 (2023) (0)
- Factor Inhibiting HIF-1 alpha in complex with HIF-1 alpha fragment peptide (2002) (0)
- Contents list. (2017) (0)
- Crystal Structure of Bacillus cereus Metallo-Beta-Lactamase with 2C (2016) (0)
- Expression of proline-hydroxylated HIF-1α predicts poorer overall survival in primary breast cancer. (2014) (0)
- Crystal structure of AmpC from E.coli with Enmetazobactam (AAI-101) (2020) (0)
- Porcine pancreatic elastase acyl enzyme at 0.95 A resolution (2002) (0)
- PORCINE PANCREATIC ELASTASE COMPLEXED WITH (3S, 4S)N-PARA-NITROBENZENESULPHONYL -3-ETHYL-4-(CARBOXYLIC ACID)PYRROLIDIN-2-ONE SOAKED IN PH 9 BUFFER FOR 2 MINUTES (2000) (0)
- Table 4, ADME profile for ML324 (2013) (0)
- Room temperature XFEL Isopenicillin N synthase structure in complex with Fe and ACV after exposure to dioxygen for 500ms without glycerol. (2021) (0)
- Structure of carbapenem synthase (CarC) complexed with N-acetyl proline (2003) (0)
- Development and validation of a cell based model of insulin resistance and investigation into the intracellular molecular defects induced by diabetes and obesity (2011) (0)
- Assessing histone demethylase inhibitors in cells: lessons learned (2017) (0)
- Reaction of (Trifluoromethyl)trimethylsilane with Oxazolidin‐5‐ones: Synthesis of Peptidic and Nonpeptidic Trifluoromethyl Ketones. (1998) (0)
- Snapshots of serine protease catalysis: unravelling the mechanism of deacylation (2002) (0)
- Porcine pancreatic elastase complexed with beta-casomorphin-7 and Arg-Phe at pH 5.0 (50 min soak) and immersed in pH 9 buffer for 28 seconds (2nd pH jump) (2006) (0)
- 19F-NMR Reveals the Role of Mobile Loops in Product and Inhibitor Binding by the Metallo--Lactamase. (2017) (0)
- The Enzymatic Synthesis of 3-Aceto-Penams Using Isopenicillin N Synthase (1990) (0)
- Structural analysis of the 2-oxoglutarate binding site of the circadian rhythm linked oxygenase JMJD5 (2022) (0)
- Structure of an N-terminal nucleophile (Ntn) hydrolase, OAT2, in complex with glutamate (2009) (0)
- Enzymatic Ring Expansion of Penicillins to Cephalosporins: Side Chain Specificity. (1987) (0)
- Proline 3-hydroxylase (type II) - Iron form (2001) (0)
- Author Correction: Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors (2020) (0)
- Synthesis and Application of Constrained Amidoboronic Acids Using Amphoteric Boron-Containing Building Blocks. (2021) (0)
- Crystal structure of human phytanoyl-CoA dioxygenase PHYHD1 (apo) (2007) (0)
- TCT-380 The Prolyl Hydroxylase Inhibitor BIQ/FG-2216 Stabilises HIF-1α and Upregulates VEGF in vitro: A Potential Strategy For Difficult CTO Lesions in Patients. (2013) (0)
- Ornithine Acetyltransferase (ORF6 Gene Product - Clavulanic Acid Biosynthesis) from Streptomyces clavuligerus (2004) (0)
- Molecular mechanism of the multifunctional enzyme L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine (ACV) synthetase. (1995) (0)
- HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with 4-hydroxy-N-(4-phenoxybenzyl)-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamide (2019) (0)
- S-nitrosylated PHD2 (NO exposed) in complex with Fe(II) and UN9 (2010) (0)
- Crystal structure of the AmpC from Pseudomonas aeruginosa with 1C (2019) (0)
- isopenicillin N synthase in complex with IPN and Fe using FT-SSX methods (2021) (0)
- Human JMJD5 (N308C) in complex with Mn(II), 2OG and RCCD1 (139-143) (complex-4) (2018) (0)
- JMJD2A COMPLEXED WITH 8-HYDROXYQUINOLINE-4-CARBOXYLIC ACID (2014) (0)
- Crystal Structure of BcII metallo-beta-lactamase in complex with DZ-305 (2018) (0)
- Crystal structure of the closed form of Pseudomonas aeruginosa SPM-1 (2014) (0)
- Enzymatic synthesis of monocyclic beta-lactams. (2002) (0)
- Crystal structure of LdtMt2 from Mycobacterium tuberculosis bound to Ebselen (2019) (0)
- The structure of ACC oxidase (2005) (0)
- Carboxyethylarginine synthase from Streptomyces clavuligerus (SeMet structure) (2003) (0)
- Identifying small molecule binding sites for epigenetic proteins at domain-domain interfaces (2018) (0)
- Aspartyl/Asparaginyl beta-hydroxylase (AspH) H679A in complex with Mn, NOG and Factor X peptide fragment (39mer-4Ser) (2020) (0)
- Porcine pancreatic elastase complexed with MetPheLeuGlu at pH 5.0 (2006) (0)
- 60S ribosomal protein L27A histidine hydroxylase (MINA53) in complex with Ni(II) and 2-oxoglutarate (2OG) (2014) (0)
- ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (ACV-FE-NO COMPLEX) (1999) (0)
- Studies on the Mechanism of Deacetoxy‐Deacetylcephalosporin C Synthase Using Cyclopropyl Substituted Cephalosporin Probes. (1992) (0)
- Factor Inhibiting HIF-1 Alpha D201A Mutant in Complex with FE(II), Alpha-Ketoglutarate and HIF-1 Alpha 35mer (2007) (0)
- Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with N-oxalylglycine (NOG) (2013) (0)
- Room temperature XFEL Isopenicillin N synthase structure in complex with Fe and IPN after dioxygen exposure (2021) (0)
- Crystal structure of OXA-10 with VNRX-5133 (2019) (0)
- Dynamic combinatorial mass spectrometry for 2-oxoglutarate oxygenase inhibition (2013) (0)
- Synthesis of Metallo-β-lactamase Inhibitors. (1997) (0)
- Biosynthetic Precursors of Valclavam (I). (2010) (0)
- JMJD2A/ KDM4A COMPLEXED WITH NI(II), NOG AND Histone H1.4(18-32)K26me3 peptide (15-mer) (2018) (0)
- Faculty Opinions recommendation of Mechanism of auxin perception by the TIR1 ubiquitin ligase. (2007) (0)
- Crystal Structure of Human gamma-butyrobetaine,2-oxoglutarate dioxygenase 1 (BBOX1) (2010) (0)
- INHIBITORS OF METALLO-BETA-LACTAMASES : WO/2018/215800 (2018) (0)
- Japan-UK Science, Technology & Innovation Symposium 2014 in London Expanding the Protein and Peptide Universe (2014) (0)
- HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) IN COMPLEX WITH 2-OXOGLUTARATE (2OG) AND HIF-1ALPHA CODD (556-574) (2016) (0)
- Crystal structure of AmpC from E.coli with Avibactam (2020) (0)
This paper list is powered by the following services:
Other Resources About Christopher J. Schofield
What Schools Are Affiliated With Christopher J. Schofield?
Christopher J. Schofield is affiliated with the following schools:
