Christopher L.-H. Huang
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Christopher L.-H. Huang's Degrees
- PhD Computer Science Stanford University
- Masters Electrical Engineering Stanford University
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Why Is Christopher L.-H. Huang Influential?
(Suggest an Edit or Addition)According to Wikipedia, Christopher L.-H. Huang FRSB is professor of cell physiology at the University of Cambridge. Christopher L.-H. Huang was awarded a Florence Heale Scholar to read Medicine and Physiology at The Queen's College, Oxford. He completed his preregistration clinical appointments in the Nuffield Department of Medicine, The John Radcliffe Hospital, Oxford. He then joined Gonville and Caius College, Cambridge as an MRC Scholar to complete a PhD in membrane biophysics, and then successively became an Assistant Lecturer and Lecturer in Physiology, Reader and finally the Professor of Cell Physiology at Cambridge, whilst being Fellow and Director of Medical Studies at Murray Edwards College. He is also independent nonexecutive director of Hutchison China Meditech and Hutchison Biofilm Solutions, and Manager of the Prince Philip Scholarship fund. He serves on the Fellowship and Advisory Boards of the British Heart Foundation His research is directed at the control of cellular activation. He thus has worked on the initiation of muscle contraction, its implications for cellular electrolyte homeostasis, the control of bone resorption under both normal and osteoporotic conditions and cortical spreading depression phenomena in the central nervous system often presaging migraine headache . His current interests are directed towards mechanisms of arrhythmogenesis in genetically modified hearts, studied using biophysical, physiological and molecular biological methods and their implications for the management of atrial fibrillation and sudden cardiac death.
Christopher L.-H. Huang's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a (2002) (401)
- A new function for CD38/ADP-ribosyl cyclase in nuclear Ca2+ homeostasis (1999) (167)
- Impaired Impulse Propagation in Scn5a-Knockout Mice: Combined Contribution of Excitability, Connexin Expression, and Tissue Architecture in Relation to Aging (2005) (166)
- Determinants of myocardial conduction velocity: implications for arrhythmogenesis (2013) (141)
- Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2. (2003) (125)
- Sinus node dysfunction following targeted disruption of the murine cardiac sodium channel gene Scn5a (2005) (121)
- Physiological studies of cortical spreading depression. (2007) (121)
- Modernized Classification of Cardiac Antiarrhythmic Drugs (2018) (121)
- Temperature dependence of human ether-a-go-go-related gene K+ currents. (2006) (111)
- Cardiac Na+ Current Regulation by Pyridine Nucleotides (2009) (109)
- Effects of premature stimulation on HERG K+ channels (2001) (108)
- Divalent cations mimic the inhibitory effect of extracellular ionised calcium on bone resorption by isolated rat osteoclasts: Further evidence for a “calcium receptor” (1991) (89)
- Genetic Na+ channelopathies and sinus node dysfunction. (2008) (86)
- TGF-&bgr;1-Mediated Fibrosis and Ion Channel Remodeling Are Key Mechanisms in Producing the Sinus Node Dysfunction Associated With SCN5A Deficiency and Aging (2011) (86)
- SCN5A and sinoatrial node pacemaker function. (2007) (85)
- A new look at sodium channel β subunits (2015) (78)
- Murine Electrophysiological Models of Cardiac Arrhythmogenesis. (2017) (78)
- Epac activation, altered calcium homeostasis and ventricular arrhythmogenesis in the murine heart (2008) (76)
- Atrial fibrillation and bisphosphonate therapy (2010) (75)
- Cortical spreading depression in the gyrencephalic feline brain studied by magnetic resonance imaging (1999) (72)
- A quantitative analysis of cell volume and resting potential determination and regulation in excitable cells (2004) (71)
- Disordered osteoclast formation and function in a CD38 (ADP‐ribosyl cyclase)‐deficient mouse establishes an essential role for CD38 in bone resorption (2003) (70)
- Sudden Death in Noncoronary Heart Disease Is Associated With Delayed Paced Ventricular Activation (2003) (69)
- A novel mechanism for coupling cellular intermediary metabolism to cytosolic Ca2+ signaling via CD38/ADP‐ribosyl cyclase, a putative intracellular NAD+ sensor (2002) (68)
- Variable Nav1.5 Protein Expression from the Wild-Type Allele Correlates with the Penetrance of Cardiac Conduction Disease in the Scn5a +/− Mouse Model (2010) (68)
- Paced Electrogram Fractionation Analysis of Arrhythmogenic Tendency in ΔKPQ Scn5a Mice (2005) (65)
- Scn3b knockout mice exhibit abnormal ventricular electrophysiological properties (2008) (65)
- Paced ventricular electrogram fractionation predicts sudden cardiac death in hypertrophic cardiomyopathy. (2008) (62)
- Cortical spreading depression and migraine: new insights from imaging? (2001) (62)
- Generation and Culture of Blood Outgrowth Endothelial Cells from Human Peripheral Blood (2015) (60)
- CELLULAR BIOLOGY OF BONE RESORPTION (1993) (59)
- Electrogram prolongation and nifedipine‐suppressible ventricular arrhythmias in mice following targeted disruption of KCNE1 (2003) (58)
- Effects of L‐type Ca2+ channel antagonism on ventricular arrhythmogenesis in murine hearts containing a modification in the Scn5a gene modelling human long QT syndrome 3 (2007) (58)
- Effects of flecainide and quinidine on arrhythmogenic properties of Scn5a+/− murine hearts modelling the Brugada syndrome (2007) (58)
- Relationships between resting conductances, excitability, and t-system ionic homeostasis in skeletal muscle (2011) (56)
- Quantitative techniques for steady-state calculation and dynamic integrated modelling of membrane potential and intracellular ion concentrations. (2007) (52)
- Ventricular arrhythmogenesis: insights from murine models. (2008) (51)
- The contribution of refractoriness to arrhythmic substrate in hypokalemic Langendorff-perfused murine hearts (2007) (51)
- Dispersions of repolarization and ventricular arrhythmogenesis: lessons from animal models. (2008) (50)
- The cardiac sodium channel mutation delQKP 1507–1509 is associated with the expanding phenotypic spectrum of LQT3, conduction disorder, dilated cardiomyopathy, and high incidence of youth sudden death (2008) (49)
- Loss of Nav1.5 expression and function in murine atria containing the RyR2-P2328S gain-of-function mutation. (2013) (48)
- Multiple targets for flecainide action: implications for cardiac arrhythmogenesis (2018) (48)
- Calcium sensing and cell signaling processes in the local regulation of osteoclastic bone resorption (2004) (48)
- Activation of the Ca2+ “receptor” on the osteoclast by Ni2+ elicits cytosolic Ca2+ signals: Evidence for receptor activation and inactivation, intracellular Ca2+ redistribution, and divalent cation modulation (1993) (48)
- Calcium and bone disease. (2011) (47)
- Diffusion-Weighted MRI Used to Detect in Vivo Modulation of Cortical Spreading Depression: Comparison of Sumatriptan and Tonabersat (2001) (46)
- Mutant MiRP1 subunits modulate HERG K+ channel gating: a mechanism for pro‐arrhythmia in long QT syndrome type 6 (2003) (46)
- Sodium channel biophysics, late sodium current and genetic arrhythmic syndromes (2017) (46)
- In vivo studies of Scn5a+/− mice modeling Brugada syndrome demonstrate both conduction and repolarization abnormalities (2010) (45)
- Increased Right Ventricular Repolarization Gradients Promote Arrhythmogenesis in a Murine Model of Brugada Syndrome (2010) (45)
- Cardiac Potassium Channels: Physiological Insights for Targeted Therapy (2017) (45)
- Principles of Optogenetic Methods and Their Application to Cardiac Experimental Systems (2019) (44)
- Calcitonin: the other thyroid hormone. (2002) (44)
- Ca(2+) influx through the osteoclastic plasma membrane ryanodine receptor. (2002) (44)
- Mkk4 Is a Negative Regulator of the Transforming Growth Factor Beta 1 Signaling Associated With Atrial Remodeling and Arrhythmogenesis With Age (2014) (43)
- Caffeine-induced arrhythmias in murine hearts parallel changes in cellular Ca(2+) homeostasis. (2005) (42)
- Calcium waves induced by hypertonic solutions in intact frog skeletal muscle fibres (2001) (42)
- Magnetic resonance imaging analysis of cardiac cycle events in diabetic rats: the effect of angiotensin‐converting enzyme inhibition (2002) (41)
- Risk stratification for sudden cardiac death. (2008) (40)
- Mechanisms of ventricular arrhythmogenesis in mice following targeted disruption of KCNE1 modelling long QT syndrome 5 (2007) (39)
- Control of Cell Volume in Skeletal Muscle (2009) (39)
- Effects of flecainide and quinidine on arrhythmogenic properties of Scn5a+/Δ murine hearts modelling long QT syndrome 3 (2007) (38)
- Ventricular arrhythmogenesis following slowed conduction in heptanol-treated, Langendorff-perfused mouse hearts (2012) (38)
- Acute atrial arrhythmogenicity and altered Ca2+ homeostasis in murine RyR2-P2328S hearts (2010) (36)
- Translational musculoskeletal science: Is sarcopenia the next clinical target after osteoporosis? (2011) (35)
- Delayed conduction and its implications in murine Scn5a+/− hearts: independent and interacting effects of genotype, age, and sex (2010) (34)
- Criteria for arrhythmogenicity in genetically-modified Langendorff-perfused murine hearts modelling the congenital long QT syndrome type 3 and the Brugada syndrome (2007) (34)
- Detection of pharmacologically mediated changes in cerebral activity by functional magnetic resonance imaging: the effects of sulpiride in the brain of the anaesthetised rat (2001) (34)
- Linkage of extracellular and intracellular control of cytosolic Ca2+ in rat osteoclasts in the presence of thapsigargin (1993) (33)
- Action potential wavelength restitution predicts alternans and arrhythmia in murine Scn5a+/− hearts (2013) (32)
- Membrane potential stabilization in amphibian skeletal muscle fibres in hypertonic solutions (2004) (32)
- The effect of intracellular acidification on the relationship between cell volume and membrane potential in amphibian skeletal muscle (2005) (31)
- A quantitative description of components of in vitro morphometric change in the rat osteoclast model: relationships with cellular function (2004) (31)
- Reduced Na+ and higher K+ channel expression and function contribute to right ventricular origin of arrhythmias in Scn5a+/− mice (2012) (31)
- Regulation of bone turnover by calcium‐regulated calcium channels (2010) (31)
- The Developmental Basis of Skeletal Cell Differentiation and the Molecular Basis of Major Skeletal Defects (2008) (29)
- Restitution analysis of alternans and its relationship to arrhythmogenicity in hypokalaemic Langendorff-perfused murine hearts (2007) (29)
- The RyR2-P2328S mutation downregulates Nav1.5 producing arrhythmic substrate in murine ventricles (2015) (29)
- The effect of extracellularly applied divalent cations on cytosolic Ca2+ in murine Leydig cells: evidence for a Ca2+‐sensing receptor (1998) (29)
- Amylin in bone conservation current evidence and hypothetical Considerations (1993) (29)
- The effect of extracellular tonicity on the anatomy of triad complexes in amphibian skeletal muscle (2004) (28)
- Deletion of the metabolic transcriptional coactivator PGC1β induces cardiac arrhythmia. (2011) (28)
- Electrogram prolongation and nifedipine-suppressible ventricular arrhythmias in mice following targeted disruption of KCNE1 (2003) (28)
- Frequency distribution analysis of activation times and regional fibrosis in murine Scn5a+/− hearts: The effects of ageing and sex (2012) (28)
- Autophagy contributes to BMP type 2 receptor degradation and development of pulmonary arterial hypertension (2019) (28)
- Late sodium current associated cardiac electrophysiological and mechanical dysfunction (2018) (28)
- Nifedipine and diltiazem suppress ventricular arrhythmogenesis and calcium release in mouse hearts (2004) (27)
- Mapping of reentrant spontaneous polymorphic ventricular tachycardia in a Scn5a+/− mouse model (2011) (27)
- Pak1 Is Required to Maintain Ventricular Ca 2+ Homeostasis and Electrophysiological Stability Through SERCA2a Regulation in Mice (2014) (27)
- Refractory dispersion promotes conduction disturbance and arrhythmias in a Scn5a+/− mouse model (2011) (26)
- The effect of heptanol on the electrical and contractile function of the isolated, perfused rabbit heart (2000) (26)
- Reciprocal dihydropyridine and ryanodine receptor interactions in skeletal muscle activation (2011) (26)
- Ageing, the autonomic nervous system and arrhythmia: From brain to heart (2018) (25)
- Altered sinoatrial node function and intra-atrial conduction in murine gain-of-function Scn5a+/ΔKPQ hearts suggest an overlap syndrome (2012) (25)
- The G604S-hERG mutation alters the biophysical properties and exerts a dominant-negative effect on expression of hERG channels in HEK293 cells (2008) (25)
- Activation of purinergic receptors by ATP induces ventricular tachycardia by membrane depolarization and modifications of Ca2+ homeostasis. (2009) (25)
- Normal conduction of surface action potentials in detubulated amphibian skeletal muscle fibres (2001) (24)
- Delayed paced ventricular activation in the long QT syndrome is associated with ventricular fibrillation. (2006) (24)
- Effect of membrane potential on surface Ca2+ receptor activation in rat osteoclasts (1995) (23)
- Factors affecting the electrocardiographic QT interval in malaria: A systematic review and meta-analysis of individual patient data (2020) (23)
- Measurement and interpretation of electrocardiographic QT intervals in murine hearts (2014) (23)
- Spatial and temporal heterogeneities are localized to the right ventricular outflow tract in a heterozygotic Scn5a mouse model (2010) (23)
- The influence of intracellular lactate and H+ on cell volume in amphibian skeletal muscle (2006) (23)
- Atrial arrhythmogenicity in aged Scn5a+/∆KPQ mice modeling long QT type 3 syndrome and its relationship to Na+ channel expression and cardiac conduction (2010) (22)
- UvA-DARE ( Digital Academic Repository ) Variable Na ( v ) 1 . 5 Protein Expression from the Wild-Type Allele Correlates with the Penetrance of Cardiac Conduction Disease in the Scn 5 a ( + /-) Mouse Model (2010) (21)
- Atrial arrhythmogenesis in wild-type and Scn5a+/Δ murine hearts modelling LQT3 syndrome (2009) (20)
- Nonlinearity between action potential alternans and restitution, which both predict ventricular arrhythmic properties in Scn5a+/- and wild-type murine hearts. (2012) (20)
- Dual actions of tetracaine on intramembrane charge in amphibian striated muscle (1997) (19)
- Abnormal Ca2+ homeostasis, atrial arrhythmogenesis, and sinus node dysfunction in murine hearts modeling RyR2 modification (2013) (19)
- Transforming growth factor &bgr; receptor inhibition prevents ventricular fibrosis in a mouse model of progressive cardiac conduction disease (2017) (19)
- Tetracyclines modulate cytosolic Ca2+ responses in the osteoclast associated with “Ca2+ receptor” activation (1993) (18)
- Slow volume transients in amphibian skeletal muscle fibres studied in hypotonic solutions (2005) (18)
- Contributions of BMPR2 Mutations and Extrinsic Factors to Cellular Phenotypes of Pulmonary Arterial Hypertension Revealed by Induced Pluripotent Stem Cell Modeling (2018) (18)
- Epac‐induced ryanodine receptor type 2 activation inhibits sodium currents in atrial and ventricular murine cardiomyocytes (2017) (16)
- Role of the pituitary-bone axis in skeletal pathophysiology (2009) (16)
- The effect of tetracyclines on quantitative measures of osteoclast morphology (1993) (16)
- Ion channel gating in cardiac ryanodine receptors from the arrhythmic RyR2-P2328S mouse (2019) (16)
- Age-dependent atrial arrhythmic phenotype secondary to mitochondrial dysfunction in Pgc-1β deficient murine hearts (2017) (16)
- Arrhythmic effects of Epac‐mediated ryanodine receptor activation in Langendorff‐perfused murine hearts are associated with reduced conduction velocity (2017) (16)
- An iPSC-Derived Myeloid Lineage Model of Herpes Virus Latency and Reactivation (2019) (16)
- Alterations in calcium homeostasis reduce membrane excitability in amphibian skeletal muscle (2006) (16)
- Osmotic ’detubulation‘ in frog muscle arises from a reversible vacuolation process (1997) (15)
- The influence of perchlorate ions on complex charging transients in amphibian striated muscle (1998) (15)
- Arrhythmogenic mechanisms of obstructive sleep apnea in heart failure patients (2018) (14)
- Alternans in Genetically Modified Langendorff-Perfused Murine Hearts Modeling Catecholaminergic Polymorphic Ventricular Tachycardia (2010) (14)
- Molecular cloning, expression, and function of osteoclastic calcineurin Aα (2003) (14)
- Acute atrial arrhythmogenicity and altered Ca 2 1 homeostasis in murine RyR 2P 2328 S hearts (2011) (14)
- Transient alterations in transmural repolarization gradients and arrhythmogenicity in hypokalaemic Langendorff‐perfused murine hearts (2007) (14)
- Effects of flecainide and quinidine on action potential and ventricular arrhythmogenic properties in Scn3b knockout mice (2010) (13)
- A quantitative analysis of the effect of cycle length on arrhythmogenicity in hypokalaemic Langendorff-perfused murine hearts (2007) (13)
- A delayed class of BOLD waveforms associated with spreading depression in the feline cerebral cortex can be detected and characterised using independent component analysis (ICA). (2003) (13)
- Mechanistic insights into ventricular arrhythmogenesis of hydroxychloroquine and azithromycin for the treatment of COVID-19 (2020) (13)
- A hypothesis for the local control of osteoclast function by Ca2+, nitric oxide and free radicals (1992) (12)
- Cardiac arrhythmogenesis: a tale of two clocks? (2019) (12)
- Pharmacological changes in cellular Ca2+ homeostasis parallel initiation of atrial arrhythmogenesis in murine langendorff-perfused hearts (2009) (12)
- Arrhythmogenic substrate and its modification by nicorandil in a murine model of long QT type 3 syndrome. (2008) (12)
- Ion channels, long QT syndrome and arrhythmogenesis in ageing (2017) (11)
- Novel insights into mechanisms for Pak1-mediated regulation of cardiac Ca2+ homeostasis (2015) (11)
- Mapping of the cerebral response to acetazolamide using graded asymmetric spin echo EPI. (2005) (11)
- 4PBA Restores Signalling of a Cysteine-substituted Mutant BMPR2 Receptor Found in Patients with PAH. (2020) (11)
- Ventricular pro-arrhythmic phenotype, arrhythmic substrate, ageing and mitochondrial dysfunction in peroxisome proliferator activated receptor-γ coactivator-1β deficient (Pgc-1β−/−) murine hearts (2018) (11)
- Determination of cable parameters in skeletal muscle fibres during repetitive firing of action potentials (2014) (10)
- Cell-Adhesion Properties of β-Subunits in the Regulation of Cardiomyocyte Sodium Channels (2020) (10)
- Differential effects of sarcoplasmic reticular Ca2+‐ATPase inhibition on charge movements and calcium transients in intact amphibian skeletal muscle fibres (2002) (10)
- Cellular and Molecular Consequences of Calcineurin Aα Gene Deletion (2007) (10)
- Age‐dependent electrocardiographic changes in Pgc‐1β deficient murine hearts (2017) (10)
- Loop diuretics inhibit detubulation and vacuolation in amphibian muscle fibres exposed to osmotic shock (2004) (10)
- Pro‐arrhythmic atrial phenotypes in incrementally paced murine Pgc1β −/− hearts: effects of age (2017) (10)
- Effect of repetitive stimulation on cell volume and its relationship to membrane potential in amphibian skeletal muscle (2006) (9)
- Ryanodine receptor modulation by caffeine challenge modifies Na+ current properties in intact murine skeletal muscle fibres (2020) (9)
- Progressive Conduction Diseases. (2010) (9)
- Pharmacological Modulation of Right Ventricular Endocardial-Epicardial Gradients in Brugada Syndrome (2018) (9)
- Alterations in triad ultrastructure following repetitive stimulation and intracellular changes associated with exercise in amphibian skeletal muscle (2007) (9)
- Update on antiarrhythmic drug pharmacology (2020) (9)
- The effects of ageing and adrenergic challenge on electrocardiographic phenotypes in a murine model of long QT syndrome type 3 (2017) (9)
- Can the SARS-CoV-2 Spike Protein Bind Integrins Independent of the RGD Sequence? (2021) (9)
- The complexity of clinically-normal sinus-rhythm ECGs is decreased in equine athletes with a diagnosis of paroxysmal atrial fibrillation (2020) (9)
- Protein expression profiles in murine ventricles modeling catecholaminergic polymorphic ventricular tachycardia: effects of genotype and sex (2020) (8)
- Gating control of the cardiac sodium channel Nav1.5 by its β3-subunit involves distinct roles for a transmembrane glutamic acid and the extracellular domain (2019) (8)
- Supramolecular clustering of the cardiac sodium channel Nav1.5 in HEK293F cells, with and without the auxiliary β3‐subunit (2020) (8)
- SERCA2a stimulation by istaroxime: a novel mechanism of action with translational implications (2013) (8)
- Understanding osteoclast formation and function: implications for future therapies for osteoporosis (2003) (8)
- Ventricular SK2 upregulation following angiotensin II challenge: Modulation by p21-activated kinase-1. (2021) (8)
- Cardiomyocyte ionic currents in intact young and aged murine Pgc-1β−/− atrial preparations (2018) (8)
- Effects of ageing on pro-arrhythmic ventricular phenotypes in incrementally paced murine Pgc-1β−/− hearts (2017) (7)
- Cardiac electrophysiological adaptations in the equine athlete—Restitution analysis of electrocardiographic features (2018) (7)
- Flecainide Paradoxically Activates Cardiac Ryanodine Receptor Channels under Low Activity Conditions: A Potential Pro-Arrhythmic Action (2021) (7)
- Cardiac glycosides inhibit detubulation in amphibian skeletal muscle fibres exposed to osmotic shock (2004) (7)
- Experimental Physiology –Research Paper: Atrial arrhythmogenic properties in wild‐type and Scn5a+/− murine hearts (2010) (7)
- ECG Restitution Analysis and Machine Learning to Detect Paroxysmal Atrial Fibrillation: Insight from the Equine Athlete as a Model for Human Athletes (2020) (7)
- Charge movements in intact amphibian skeletal muscle fibres in the presence of cardiac glycosides (2001) (7)
- Extracellular Charge Adsorption Influences Intracellular Electrochemical Homeostasis in Amphibian Skeletal Muscle (2008) (7)
- Pathophysiological Mechanisms of Sino-Atrial Dysfunction and Ventricular Conduction Disease Associated with SCN5A Deficiency: Insights from Mouse Models (2012) (6)
- Molecular basis of arrhythmic substrate in ageing murine peroxisome proliferator-activated receptor γ co-activator deficient hearts modelling mitochondrial dysfunction (2019) (6)
- Ca2+-dependent modulation of voltage-gated myocyte sodium channels (2021) (6)
- Regulatory actions of 3′,5′‐cyclic adenosine monophosphate on osteoclast function: possible roles of Epac‐mediated signaling (2018) (6)
- Sodium current inhibition following stimulation of exchange protein directly activated by cyclic-3′,5′-adenosine monophosphate (Epac) in murine skeletal muscle (2019) (6)
- Arrhythmogenic actions of the Ca2+ channel agonist FPL-64716 in Langendorff-perfused murine hearts (2008) (6)
- Similarities and Contrasts in Ryanodine Receptor Localization and Function in Osteoclasts and Striated Muscle Cells (2007) (6)
- Autonomic modulation of the electrical substrate in mice haploinsufficient for cardiac sodium channels: a model of the Brugada syndrome. (2019) (6)
- A BMPR2/YY1 Signaling Axis Is Required for Human Cytomegalovirus Latency in Undifferentiated Myeloid Cells (2021) (5)
- Membrane potentials in Rana temporaria muscle fibres in strongly hypertonic solutions (2006) (5)
- The application of Lempel-Ziv and Titchener complexity analysis for equine telemetric electrocardiographic recordings (2019) (5)
- Spatial and temporal heterogeneities are localized to the right ventricular outflow tract in a heterozygotic Scn 5 a mouse model (2011) (5)
- Sarcoplasmic reticular Ca2+-ATPase inhibition paradoxically upregulates murine skeletal muscle Nav1.4 function (2021) (5)
- Reduced cardiomyocyte Na+ current in the age‐dependent murine Pgc‐1β −/− model of ventricular arrhythmia (2018) (5)
- The cardiac CaMKII-Nav1.5 relationship: From physiology to pathology. (2020) (5)
- Detubulation abolishes membrane potential stabilization in amphibian skeletal muscle (2004) (5)
- Generation of induced pluripotent stem cells (iPSCs) from an infant with catecholaminergic polymorphic ventricular tachycardia carrying the double heterozygous mutations A1855D in RyR2 and Q1362H in SCN10A. (2019) (5)
- From channels to systems: Ca2+‐sensitive K+ currents, alternans and cardiac arrhythmia (2017) (4)
- Electrophysiological and Proarrhythmic Effects of Hydroxychloroquine Challenge in Guinea-Pig Hearts. (2021) (4)
- Editorial: Ca2+ Signaling and Heart Rhythm (2016) (4)
- Cellular and molecular consequences of calcineurin A alpha gene deletion. (2007) (4)
- Late sodium current associated cardiac electrophysiological and mechanical dysfunction (2017) (4)
- How does flecainide impact RyR2 channel function? (2022) (4)
- The SCN5A Mutation A1180V is Associated With Electrocardiographic Features of LQT3 (2014) (4)
- Anti-arrhythmic effects of cyclopiazonic acid in Langendorff-perfused murine hearts. (2008) (4)
- Gating of RYR2 channels from the arrhythmic RYR2-P2328S mouse heart and some unexpected actions of flecainide. (2021) (3)
- Molecular basis of ventricular arrhythmogenicity in a Pgc-1α deficient murine model (2021) (3)
- Characterisation of the osteoclast calcium “receptor”: evidence for a novel receptor-operated calcium channel and intracellular mobilisation (1992) (3)
- Ageing in Pgc-1β−/− mice modelling mitochondrial dysfunction induces differential expression of a range of genes regulating ventricular electrophysiology (2019) (3)
- Gene and Protein Expression Profile of Selected Molecular Targets Mediating Electrophysiological Function in Pgc-1α Deficient Murine Atria (2018) (3)
- Persistent tubular conduction in vacuolated amphibian skeletal muscle following osmotic shock (2004) (3)
- Chapter 28 - Genetics and Cell Biology of Calcitonin Action (1997) (3)
- Translational imaging studies of cortical spreading depression in experimental models for migraine aura (2008) (3)
- Empirical correlation of triggered activity and spatial and temporal re-entrant substrates with arrhythmogenicity in a murine model for Jervell and Lange-Nielsen syndrome (2009) (3)
- Cardiac arrhythmogenesis is a major clinical problem. (2008) (3)
- Computational analysis of the electromechanical consequences of short QT syndrome (2015) (3)
- Atrial Transcriptional Profiles of Molecular Targets Mediating Electrophysiological Function in Aging and Pgc-1β Deficient Murine Hearts (2019) (3)
- Finite element analysis predicts Ca2+ microdomains within tubular-sarcoplasmic reticular junctions of amphibian skeletal muscle (2021) (2)
- Separation of detubulation and vacuolation phenomena in amphibian skeletal muscle (2004) (2)
- Detubulation experiments localise delayed rectifier currents to the surface membrane of amphibian skeletal muscle fibres (2004) (2)
- The RyR2-P2328S mutation downregulates Na v 1.5 (2015) (2)
- Transcriptional profiles of genes related to electrophysiological function in Scn5a +/− murine hearts (2021) (2)
- Clinically compatible advances in blood-derived endothelial progenitor cell isolation and reprogramming for translational applications. (2021) (2)
- A novel mechanism for coupling cellular intermediary metabolism to cytosolic Ca 2 (cid:1) signaling via CD38/ADP-ribosyl cyclase, a putative intracellular NAD (cid:1) sensor (2002) (2)
- Paced electrogram fractionation analysis (PEFA) of arrhythmogenic tendency in deltaKPQ Scn5a (Long QT 3) mice (2005) (2)
- OSMOTIC PROCESSES IN VACUOLATION AND DETUBULATION OF SKELETAL MUSCLE (2002) (2)
- SOX17 Deficiency Impairs Tube Network Formation Through the Reduction of Arterial Identity in Pulmonary Arterial Hypertension (2020) (1)
- FPL-64176 alters both charge movement and Ca2+ release properties in amphibian muscle fibres (2004) (1)
- Editorial: Optogenetics: An Emerging Approach in Cardiac Electrophysiology (2020) (1)
- The Voltage-Dependent Sodium Channel Family (2018) (1)
- Physiological studies of cortical spreading depression (2006) (1)
- Ca2+ Signaling and Heart Rhythm (2016) (1)
- Sinus node dysfunction following targeted disruption of the cardiac sodium channel gene, Scn5a (2005) (1)
- Cardiac sodium channel complexes and arrhythmia: structural and functional roles of the β1 and β3 subunits (2022) (1)
- Overview: Inhibitors of Bone Resorption and Implications for Therapy (1992) (1)
- The β3-subunit modulates the effect of venom peptides ProTx-II and OD1 on NaV 1.7 gating. (2023) (0)
- iPSCs derived from endothelial progenitors model latency and reactivation during human cytomegalovirus infection (2019) (0)
- Elevated cytosolic calcium levels in human lymphocytes during surface virus infections (1994) (0)
- Ventricular arrhythmogenesis following slowed conduction in heptanol-treated, Langendorff-perfused mouse hearts (2012) (0)
- The Relationship Between Conduction Velocity and Atrial Arrhythmogenicity under Conditions of Altered Ca2+ Homeostasis in RyR2-P2328S Murine Hearts (2012) (0)
- Assessment of magnitude and dispersion of epicardial conduction velocity in Langendorff perfused murine hearts (2012) (0)
- The effects of ageing and adrenergic challenge on electrocardiographic phenotypes in a murine model of long QT syndrome type 3 (2017) (0)
- Editor's evaluation: iMyoblasts for ex vivo and in vivo investigations of human myogenesis and disease modeling (2021) (0)
- Effects of ageing on pro-arrhythmic ventricular phenotypes in incrementally paced murine Pgc-1β−/− hearts (2017) (0)
- Response by Lei et al to Letter Regarding Article, "Modernized Classification of Cardiac Antiarrhythmic Drugs". (2019) (0)
- Acidification protects skeletal muscle volume during anaerobic exercise: Biophysical measurements and theoretical modelling of resting skeletal muscle exposed to extracellular lactate demonstrate that intracellular buffering of hydrogen ions precisely offsets the effect of increased intracellular la (2007) (0)
- Sodium channel biophysics, late sodium current and genetic arrhythmic syndromes (2017) (0)
- Roger Yonchien Tsien. 1 February 1952—24 August 2016 (2018) (0)
- MKK4 is a negative regulator of the TGF- β 1 signaling associated with atrial remodelling and arrhythmogenesis with age Davies, and atrial arrhythmogenesis (2013) (0)
- 62 Gender effects on protein expression profiles related to arrhythmic phenotype in murine ventricles modelling catecholaminergic polymorphic ventricular tachycardia (2020) (0)
- MIRNA-FACILITATED SELF-REPLICATIVE RNA (SRRNA) REPROGRAMMING OF ENDOTHELIAL PROGENITOR CELLS (EPCS) DERIVED FROM HUMAN PERIPHERAL BLOOD AND CORD BLOOD (2015) (0)
- Molecular basis of arrhythmic substrate in ageing, Pgc-1β-deficient murine hearts modelling mitochondrial dysfunction (2018) (0)
- Abstract 8633: Right Ventricular Origin of Arrhythmias in Scn5a+/- Mice Modeling Brugada Syndrome is Due to Reduced Na+ and Higher K+ Channel Expression and Function in the Right Ventricle (2011) (0)
- Electrophysiological Determinants for Arrhythmogenesis Following Premature Stimulation In Murine Hearts (2010) (0)
- Molecular cloning, expression, and function of osteoclastic calcineurin Aalpha. (2003) (0)
- Pharmacological modulation of right ventricular endocardial-epicardial gradients 1 in Brugada Syndrome 2 3 4 (2018) (0)
- Cardiac & Respiratory Physiology Themed Meeting (2013) (0)
- Antiarrhythmic drugs – An updated classification after 50 years (2020) (0)
- A Comparative Study of Systolic and Diastolic Mechanical Synchrony in Canine, Primate, and Healthy and Failing Human Hearts (2021) (0)
- Abstract 2568: Metabolic Control of Cardiac Na+ Current Through Pyridine Nucleotides (2009) (0)
- Scn5a deficiency and ageing associated sinus node dysfunction: contribution of ion channel remodeling and TGF-??1 related fibrosis (2010) (0)
- P115Pak1 is required to maintain ventricular Ca2+ homeostasis and electrophysiological stability through SERCA2a regulation in mice. (2014) (0)
- Editor's evaluation: The role of action potential changes in depolarization-induced failure of excitation contraction coupling in mouse skeletal muscle (2021) (0)
- Cardiomyocyte electrophysiology and its modulation: current views and future prospects (2023) (0)
- The RyR2-P2328S mutation downregulates Nav1.5 producing a ventricular arrhythmic substrate in murine ventricles. (2015) (0)
- The complexity of clinically-normal sinus-rhythm ECGs is decreased in equine athletes with a diagnosis of paroxysmal atrial fibrillation (2020) (0)
- Ventricular arrhythmogenesis in Nav1.5-haploinsufficient murine hearts (2012) (0)
- Ion Channel Function and Cardiac Arrhythmogenesis (2020) (0)
- Cellular Ionic Homeostatic Processes in Osteoclastic Bone Resorption (2020) (0)
- Nav1.5 deficiency triggered TGF-β1-mediated fibrosis as a key mechanism producing sinus node dysfunction associated with Scn5a disruption and aging in mice (2011) (0)
- Biology of Calcitonin as An Osteoprotective Agent (2020) (0)
- Pathological turret mutations in the cardiac sodium channel cause long-range pore disruption (2021) (0)
- Age-related cardiac conduction slowing in PGC-1β-/- hearts (2016) (0)
- Slow conduction in mouse hearts with targeted disruption of the cardiac sodium channel gene, Scn5a (2005) (0)
- Magnetic resonanceimaging planes forthe3-dimensional characterisation ofhumancoronaryarteries (1994) (0)
- Review SCN5A and sinoatrial node pacemaker function (2007) (0)
- Structure and Function of Skeletal Muscle (2020) (0)
- The RyR2-P2328S mutation downregulates Nav1.5 producing arrhythmic substrate in murine ventricles (2015) (0)
- Abstract 11020: Multi Array Mapping Demonstrates both Conduction Delay and Repolarization Abnormalities in a Murine Model of Brugada Syndrome (2010) (0)
- Calcium and contractility: smooth muscle: edited by A. K. Grover and E. E. Daniel, The Humana Press Inc, 1985. $64.50 (USA) $74.50 (elsewhere) (xx + 487 pages) ISBN 0 89603 068 7 (1986) (0)
- The interdependence of cell volume and resting membrane potential (2005) (0)
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