Christopher Pittenger
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Christopher Pittenger's Degrees
- PhD Neuroscience Stanford University
Why Is Christopher Pittenger Influential?
(Suggest an Edit or Addition)According to Wikipedia, Christopher J. Pittenger is an American psychiatrist and translational neuroscientist. He is a professor of psychiatry at the Yale School of Medicine and Director of the Yale OCD Research Clinic. Early life and education Pittenger was born in 1972 in Baltimore, Maryland to parents Judy MacGillivray and Arthur Pittenger. Growing up, he was a choirboy at St. Davids Episcopal Church and attended Friends School of Baltimore. Pittenger completed his Bachelor of Science degree in 1994 from Yale University and his PhD in 2002 from Columbia University. During college, Pittenger discovered that "neurobiology was an ideal way to synthesize his interests in molecular biology and human psychology." While completing his doctorate under the guidance of Eric Kandel, he accidentally altered the striatum in mice, instead of altering the hippocampus. Pittenger then worked towards his medical degree, which he earned in 2003 at Columbia University Vagelos College of Physicians and Surgeons, and his residency in Adult Psychiatry in 2007.
Christopher Pittenger's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms (2008) (1608)
- Analysis of shared heritability in common disorders of the brain (2016) (1385)
- Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders (2019) (724)
- Reversible Inhibition of CREB/ATF Transcription Factors in Region CA1 of the Dorsal Hippocampus Disrupts Hippocampus-Dependent Spatial Memory (2002) (487)
- Meta-analysis of the symptom structure of obsessive-compulsive disorder. (2008) (483)
- Blocking TGF-β–Smad2/3 innate immune signaling mitigates Alzheimer-like pathology (2008) (412)
- Some Forms of cAMP-Mediated Long-Lasting Potentiation Are Associated with Release of BDNF and Nuclear Translocation of Phospho-MAP Kinase (2001) (351)
- Altered global brain signal in schizophrenia (2014) (324)
- Glutamate abnormalities in obsessive compulsive disorder: neurobiology, pathophysiology, and treatment. (2011) (323)
- Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture (2013) (280)
- Riluzole Augmentation in Treatment-Resistant Obsessive–Compulsive Disorder: An Open-Label Trial (2005) (279)
- Characterization of a mutant strain of Saccharomyces cerevisiae with a deletion of the RAD27 gene, a structural homolog of the RAD2 nucleotide excision repair gene (1995) (269)
- Genome-wide association study of obsessive-compulsive disorder (2013) (256)
- Microglial Dysregulation in Psychiatric Disease (2013) (243)
- Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis. (2017) (235)
- Systematic Review: Pharmacological and Behavioral Treatment for Trichotillomania (2007) (231)
- Meta-analysis of the dose-response relationship of SSRI in obsessive-compulsive disorder (2010) (214)
- Global Resting-State Functional Magnetic Resonance Imaging Analysis Identifies Frontal Cortex, Striatal, and Cerebellar Dysconnectivity in Obsessive-Compulsive Disorder (2014) (212)
- Toward a neurobiology of psychotherapy: basic science and clinical applications. (2005) (208)
- N-acetylcysteine augmentation in serotonin reuptake inhibitor refractory obsessive-compulsive disorder (2005) (199)
- The NMDA receptor as a therapeutic target in major depressive disorder. (2007) (192)
- CREB, memory enhancement and the treatment of memory disorders: promises, pitfalls and prospects (2003) (184)
- In search of general mechanisms for long-lasting plasticity: Aplysia and the hippocampus. (2003) (182)
- Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer’s disease mouse model (2010) (171)
- Glutamate-modulating drugs as novel pharmacotherapeutic agents in the treatment of obsessive-compulsive disorder (2011) (164)
- Orbitofrontal cortex neurofeedback produces lasting changes in contamination anxiety and resting-state connectivity (2013) (156)
- Riluzole in the Treatment of Mood and Anxiety Disorders (2008) (155)
- Pharmacological treatment of obsessive-compulsive disorder. (2014) (152)
- Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice (2014) (148)
- N-Acetylcysteine in the treatment of pediatric trichotillomania: a randomized, double-blind, placebo-controlled add-on trial. (2013) (143)
- A double dissociation revealing bidirectional competition between striatum and hippocampus during learning (2008) (136)
- Cognitive inflexibility in Obsessive-Compulsive Disorder (2017) (133)
- The past, the future and the biology of memory storage. (1999) (130)
- Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD. (2015) (123)
- Impaired Bidirectional Synaptic Plasticity and Procedural Memory Formation in Striatum-Specific cAMP Response Element-Binding Protein-Deficient Mice (2006) (114)
- Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome (2015) (112)
- Dissociable regulation of instrumental action within mouse prefrontal cortex (2010) (110)
- Association of the serotonin transporter polymorphism and obsessive‐compulsive disorder: Systematic review (2008) (109)
- Copy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study. (2014) (109)
- Effects of Ketamine in Treatment-Refractory Obsessive-Compulsive Disorder (2012) (105)
- Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines (2019) (98)
- Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice (2014) (97)
- Meta-Analysis: Hoarding Symptoms Associated with Poor Treatment Outcome in Obsessive-Compulsive Disorder (2014) (93)
- Recent advances in Tourette syndrome. (2011) (92)
- Orbitofrontal Circuits Control Multiple Reinforcement-Learning Processes (2019) (92)
- Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [11C]ABP688 and PET imaging study in depression (2017) (90)
- Time course of clinical change following neurofeedback (2018) (80)
- A genetic switch for long-term memory. (1998) (78)
- Dimensional predictors of response to SRI pharmacotherapy in obsessive-compulsive disorder. (2010) (73)
- Disorders of memory and plasticity in psychiatric disease (2013) (68)
- Riluzole augmentation in treatment-refractory obsessive-compulsive disorder: a series of 13 cases, with long-term follow-up. (2008) (65)
- Age and gender correlates of pulling in pediatric trichotillomania. (2013) (64)
- The tyrosine phosphatase STEP: implications in schizophrenia and the molecular mechanism underlying antipsychotic medications (2012) (64)
- Ablation of fast-spiking interneurons in the dorsal striatum, recapitulating abnormalities seen post-mortem in Tourette syndrome, produces anxiety and elevated grooming (2016) (64)
- The Role of Stress in the Pathogenesis and Maintenance of Obsessive-Compulsive Disorder (2018) (63)
- Gabapentin abuse, and delirium tremens upon gabapentin withdrawal. (2007) (62)
- Microglial Dysregulation in OCD, Tourette Syndrome, and PANDAS (2016) (61)
- Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium (2020) (61)
- Decision-making under uncertainty in obsessive-compulsive disorder. (2015) (61)
- A form of long-lasting, learning-related synaptic plasticity in the hippocampus induced by heterosynaptic low-frequency pairing. (2004) (61)
- Dimensional correlates of poor insight in obsessive–compulsive disorder (2011) (59)
- Resting state functional connectivity predicts neurofeedback response (2014) (57)
- Lesions of the dorsomedial striatum disrupt prepulse inhibition (2011) (56)
- Riluzole augmentation in treatment-refractory obsessive-compulsive disorder: a pilot randomized placebo-controlled trial. (2015) (56)
- Histamine regulation of microglia: Gene-environment interaction in the regulation of central nervous system inflammation (2016) (55)
- Randomized, Double-Blind, Placebo-Controlled Trial of N-Acetylcysteine Augmentation for Treatment-Resistant Obsessive-Compulsive Disorder. (2017) (55)
- Early onset of response with selective serotonin reuptake inhibitors in obsessive-compulsive disorder: a meta-analysis. (2016) (54)
- Corticostriatal interactions in the generation of tic-like behaviors after local striatal disinhibition (2015) (54)
- The Role of Interneurons in Autism and Tourette Syndrome (2017) (52)
- Dysregulated intracellular signaling in the striatum in a pathophysiologically grounded model of Tourette syndrome (2014) (52)
- Histamine and histamine receptors in Tourette syndrome and other neuropsychiatric conditions (2016) (51)
- Targeted Interneuron Depletion in the Dorsal Striatum Produces Autism-like Behavioral Abnormalities in Male but Not Female Mice (2017) (51)
- LONG‐TERM OUTCOME IN ADULTS WITH OBSESSIVE‐COMPULSIVE DISORDER (2013) (50)
- Meta-Analysis of the Symptom Structure of Obsessive-Compulsive Disorder (2015) (48)
- Regulation of Alcohol Extinction and Cue-Induced Reinstatement by Specific Projections among Medial Prefrontal Cortex, Nucleus Accumbens, and Basolateral Amygdala (2017) (48)
- Symptom dimensions are associated with age of onset and clinical course of obsessive–compulsive disorder (2013) (46)
- Histidine decarboxylase knockout mice, a genetic model of Tourette syndrome, show repetitive grooming after induced fear (2015) (46)
- An overview of the first 5 years of the ENIGMA obsessive–compulsive disorder working group: The power of worldwide collaboration (2020) (42)
- Initial evidence of the beneficial effects of glutamate-modulating agents in the treatment of self-injurious behavior associated with borderline personality disorder. (2005) (42)
- Glutamatergic agents for OCD and related disorders (2015) (41)
- The Histamine H3 Receptor Differentially Modulates Mitogen-activated Protein Kinase (MAPK) and Akt Signaling in Striatonigral and Striatopallidal Neurons* (2016) (40)
- Two cases of delayed-onset suicidal ideation, dysphoria and anxiety after ketamine infusion in patients with obsessive–compulsive disorder and a history of major depressive disorder (2013) (40)
- Arbitration between Action Strategies in Obsessive-Compulsive Disorder (2016) (39)
- Beneficial effects of the glutamate-modulating agent riluzole on disordered eating and pathological skin-picking behaviors. (2006) (37)
- Histamine modulation of the basal ganglia circuitry in the development of pathological grooming (2017) (35)
- CREB selectively controls learning-induced structural remodeling of neurons. (2012) (34)
- Striatum‐dependent habits are insensitive to both increases and decreases in reinforcer value in mice (2013) (34)
- Genome-wide association study of obsessive-compulsive disorder (2013) (33)
- Histamine H3R receptor activation in the dorsal striatum triggers stereotypies in a mouse model of tic disorders (2017) (33)
- OCD is associated with an altered association between sensorimotor gating and cortical and subcortical 5-HT1b receptor binding. (2016) (33)
- Clinical treatment of obsessive compulsive disorder. (2005) (32)
- Differential binding of antibodies in PANDAS patients to cholinergic interneurons in the striatum (2017) (32)
- Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models (2016) (32)
- Modeling tics in rodents: Conceptual challenges and paths forward (2017) (31)
- Beneficial effects of the antiglutamatergic agent riluzole in a patient diagnosed with trichotillomania. (2007) (31)
- Inhibition of CREB Activity in the Dorsal Portion of the Striatum Potentiates Behavioral Responses to Drugs of Abuse (2009) (30)
- Glutamate modulators in the treatment of obsessive-compulsive disorder. (2015) (30)
- Histidine Decarboxylase Knockout Mice as a Model of the Pathophysiology of Tourette Syndrome and Related Conditions. (2017) (29)
- Tourette disorder and other tic disorders. (2018) (28)
- Antibodies From Children With PANDAS Bind Specifically to Striatal Cholinergic Interneurons and Alter Their Activity. (2020) (27)
- Lesions of the dorsomedial striatum delay spatial learning and render cue-based navigation inflexible in a water maze task in mice (2014) (27)
- Real-time fMRI biofeedback targeting the orbitofrontal cortex for contamination anxiety. (2012) (26)
- Trio Haploinsufficiency Causes Neurodevelopmental Disease–Associated Deficits (2019) (25)
- Association of polymorphisms in HCN4 with mood disorders and obsessive compulsive disorder (2011) (25)
- High levels of histidine decarboxylase in the striatum of mice and rats (2011) (23)
- Neural Correlates of Success and Failure Signals During Neurofeedback Learning (2016) (20)
- Value-based decision making under uncertainty in hoarding and obsessive- compulsive disorders (2017) (19)
- Contrasting contributions of anhedonia to obsessive-compulsive, hoarding, and post-traumatic stress disorders. (2019) (19)
- Intranasal Ketamine and Cognitive-Behavioral Therapy for Treatment-Refractory Obsessive-Compulsive Disorder. (2017) (18)
- Imagery rescripting as an adjunct clinical intervention for obsessive compulsive disorder. (2019) (18)
- Glutamatergic dysfunction in obsessive-compulsive disorder and the potential clinical utility of glutamate-modulating agents (2006) (17)
- Cued and spatial learning in the water maze: Equivalent learning in male and female mice (2010) (17)
- Genetic susceptibility in obsessive-compulsive disorder. (2018) (15)
- Toward understanding the heterogeneity in obsessive-compulsive disorder: Evidence from narratives in adult patients (2016) (15)
- Tourette Syndrome and Tic Disorders (2013) (15)
- Genome-wide association study of pediatric obsessive-compulsive traits: shared genetic risk between traits and disorder (2019) (14)
- Animal Models of Tourette Syndrome and Obsessive-Compulsive Disorder (2015) (14)
- Visual hallucinations from the addition of riluzole to memantine and bupropion. (2006) (11)
- Transcranial direct current stimulation targeting the medial prefrontal cortex modulates functional connectivity and enhances safety learning in obsessive‐compulsive disorder: Results from two pilot studies (2021) (11)
- Inhibitory regulation of calcium transients in prefrontal dendritic spines is compromised by a nonsense Shank3 mutation (2020) (9)
- Striatal Signaling Regulated by the H3R Histamine Receptor in a Mouse Model of tic Pathophysiology (2018) (9)
- Unbending mind: Individuals with hoarding disorder do not modify decision strategy in response to feedback under risk (2018) (9)
- Pharmacological antagonism of histamine H2R ameliorated L-DOPA–induced dyskinesia via normalization of GRK3 and by suppressing FosB and ERK in PD (2019) (9)
- Risky Business: The Circuits that Impact Stress-Induced Decision-Making (2017) (8)
- Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta-and Mega-Analysis (vol , pg , 2016) (2017) (8)
- The Genetics of Obsessive-Compulsive Disorder. (2010) (8)
- Genome-wide association study identifies new locus associated with OCD (2021) (7)
- Pharmacotherapeutic Strategies and New Targets in OCD. (2021) (7)
- Recent Insights on DNA Repair: The Mechanism of Damaged Nucleotide Excision in Eukaryotes and Its Relationship to Other Cellular Processes a (1994) (6)
- The histidine decarboxylase model of tic pathophysiology: a new focus on the histamine H3 receptor (2019) (6)
- Probing Implicit Learning in Obsessive-Compulsive Disorder: Moderating Role of Medication on the Weather Prediction Task. (2016) (6)
- Animal models of OCD-relevant processes: an RDoC perspective. (2019) (5)
- Are there Biological Commonalities among Different Psychiatric Disorders (2015) (5)
- Specialty knowledge and competency standards for pharmacotherapy for adult obsessive-compulsive disorder (2021) (5)
- Global resting-state fMRI analysis identifies frontal cortex, striatal, and cerebellar dysconnectivity in obsessive-compulsive disorder (2014) (5)
- Riluzole augmentation in treatment-refractory obsessive- compulsive disorder: a pilot placebo-controlled trial (2015) (5)
- Epigenetic modification of the BDNF locus by early-life enrichment: Towards a molecular correlate of resilience? (2011) (4)
- The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder (2022) (4)
- Pathophysiological Modeling of Obsessive-Compulsive Disorder: Challenges, and Progress (2011) (4)
- Developing image sets for inducing obsessive-compulsive checking symptoms (2018) (3)
- Cyclic Nucleotides in the Nervous System (2012) (3)
- Blocking TGF-b – Smad 2 / 3 innate immune signaling mitigates Alzheimer ’ s-like pathology (2008) (3)
- Electroencephalographic Correlates and Predictors of Treatment Outcome in OCD: A Brief Narrative Review (2021) (3)
- The Roles of Endogenous Opioid System in the Antidepressant Actions of Ketamine (2021) (2)
- Tourette's syndrome and translational clinical science. (2015) (2)
- Correction: Mapping brain-behavior space relationships along the psychosis spectrum (2022) (2)
- [Past and future studies of memory]. (2003) (2)
- Disgust sensitivity mediates the effects of race on contamination aversion. (2018) (2)
- Exploring Retrospective Biases in Obsessive-Compulsive Disorder: an Experience-Sampling Study (2018) (2)
- Cholinergic neurons in the basal forebrain are involved in behavioral abnormalities associated with Cul3 deficiency: Role of prefrontal cortex projections in cognitive deficits (2023) (2)
- OCD Influences Evidence Accumulation During Decision Making in Males but Not Females During Perceptual and Value-Driven Choice (2021) (2)
- Decision-making under uncertainty in obsessiveecompulsive disorder (2015) (1)
- Methylone, a rapid acting entactogen with robust anxiolytic and antidepressant-like activity (2023) (1)
- The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium. (2023) (1)
- Decision-making under uncertainty in obsessive e compulsive disorder (2015) (1)
- Distinct but Synergistic Roles for Histone Deacetylase in the Dorsal Striatum During Habit Formation (2018) (1)
- 332. 5-MeO-DMT Modifies Innate Behaviors and Promotes Structural Neural Plasticity in Mice (2022) (1)
- Obsessive compulsive symptom dimensions are linked to altered white-matter microstructure in a community sample of youth (2022) (1)
- Treatment of obsessive-compulsive disorder with frontopolar multifocal transcranial direct current stimulation and exposure and response prevention: A case Series (2021) (1)
- Biology in the Service of Psychotherapy (2005) (1)
- Poster Session II (2011) (1)
- The histamine H3 receptor modulates dopamine D2 receptor–dependent signaling pathways and mouse behaviors (2023) (0)
- Psychedelics (2022) (0)
- 37.5 PATHOPHYSIOLOGICALLY GROUNDED MODELS OF TIC DISORDERS: HISTAMINE DYSREGULATION IN TOURETTE'S DISORDER (2016) (0)
- Imagery Rescripting (ImRs) as an Adjunctive Treatment to Exposure and Response Prevention (ERP)-Resistant Obsessive-Compulsive Disorder: A Case Study (2022) (0)
- Comments on ''Efficacy of Quetiapine Monotherapy in Bipolar I and II (2008) (0)
- Exploring Retrospective Biases in Obsessive-Compulsive Disorder: an Experience-Sampling Study (2018) (0)
- 19.1 Renaissance in Psychedelic Research (2022) (0)
- Excessive acquisition of information during simple judgments in individuals with hoarding disorder (2020) (0)
- Transcranial direct current stimulation (tDCS) targeting the medial prefrontal cortex (mPFC) modulates functional connectivity and enhances inhibitory safety learning in obsessive-compulsive disorder (OCD) (2021) (0)
- Response to Chamberlain et al. Re: Systematic Review: Pharmacological and Behavioral Treatments for Trichotillomania (2008) (0)
- Author Correction: Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines (2021) (0)
- Structural neuroimaging biomarkers for obsessive-compulsive disorder in the ENIGMA-OCD medication matters. (2020) (0)
- The thalamus and its subnuclei: a gateway to obsessive-compulsive disorder findings from the ENIGMA-OCD Working Group (2021) (0)
- T18. Characterizing Reward Responsiveness in Obsessive-Compulsive Disorder and Schizophrenia Through a Probabilistic Reward Task (2018) (0)
- Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome (2022) (0)
- F16. Aberrant Causal Reasoning in Obsessive-Compulsive Disorder (OCD) (2019) (0)
- 511. Common and Distinct Effects of Incentives on Spatial Working Memory in Schizophrenia and Obsessive-Compulsive Disorder (2023) (0)
- 348. Sexual Dimorphism in the Behavioral Outcomes Following Early Life Stress (2023) (0)
- Does Internal Preoccupation with Obsessive-Compulsive Themes Affect Externally Oriented Functioning in OCD?: Behavioral Results and Clinical Cases (2022) (0)
- Circuit- and Behavioral- Level Investigation of Plasticity After Administration of Entactogens in Mice (2023) (0)
- O4-02-06: Blocking Tgf-β–smad 2/3 innate immune signaling mitigates Alzheimer-like pathology in transgenic mice (2008) (0)
- Supplemental Information Running Title : Global Signal in Schizophrenia 1 SUPPLEMENTAL INFORMATION Altered Global Brain Signal in Schizophrenia (2014) (0)
- White matter abnormalities in the Hdc knockout mouse, a model of tic and OCD pathophysiology (2022) (0)
- From Bedside to Bench and Back Again: Tourette Syndrome and Translational Clinical Science (2015) (0)
- P456. The Effects of Early Life Stress on Tourette Syndrome-Relevant Pathology (2022) (0)
- Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines (2020) (0)
- Neuroinflammation in Obsessive-Compulsive Disorder: Sydenham Chorea, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections, and Pediatric Acute Onset Neuropsychiatric Syndrome. (2023) (0)
- ACNP 56th Annual Meeting: Poster Session II, December 5, 2017 (2017) (0)
- Histaminergic Regulation of Stereotyped Movements in a Mouse Model of Repetitive Motor Behavior (2020) (0)
- 390. Altered Confidence Adaptation During Set-Shifting in OCD (2023) (0)
- Prefrontal allopregnanolone mediates the adverse effects of acute stress in a mouse model of tic pathophysiology (2022) (0)
- Safety, tolerability, and clinical and neural effects of single-dose psilocybin in obsessive–compulsive disorder: protocol for a randomized, double-blind, placebo-controlled, non-crossover trial (2023) (0)
- The Pharmacological Treatment of Obsessive-Compulsive Disorder. (2023) (0)
- High levels of histamine decarboxylase in the striatum of mice and rats (2011) (0)
- Author Correction: Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines (2021) (0)
- Diseases of the Mind and Diseases of the Brain Mind and Brain in Psychiatric Disease (2007) (0)
- Single-dose psilocybin for treatment-resistant obsessive-compulsive disorder: A case report (2022) (0)
- Obsessive Compulsive Symptom Dimensions are Linked to Altered White Matter Microstructure in a Community Sample of Adolescents (2021) (0)
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