Christopher T. Walsh
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American biochemist
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Biology
Why Is Christopher T. Walsh Influential?
(Suggest an Edit or Addition)According to Wikipedia, Christopher T. Walsh was a Hamilton Kuhn professor of biological chemistry and pharmacology at Harvard Medical School. His research focused on enzymes and enzyme inhibition, and most recently focused on the problem of antibiotic resistance. He was elected to the National Academy of Sciences in 1989.
Christopher T. Walsh's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Antibiotics for Emerging Pathogens (2009) (1596)
- Molecular mechanisms that confer antibacterial drug resistance (2000) (1398)
- Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. (2013) (1360)
- Protein posttranslational modifications: the chemistry of proteome diversifications. (2005) (1218)
- Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms. (2006) (1208)
- Lessons from natural molecules (2004) (983)
- Antibiotics: Actions, Origins, Resistance (2003) (885)
- A new enzyme superfamily - the phosphopantetheinyl transferases. (1996) (736)
- Genetics and Assembly Line Enzymology of Siderophore Biosynthesis in Bacteria (2002) (732)
- Enzymatic Reaction Mechanisms (1978) (678)
- Opinion — anti-infectives: Where will new antibiotics come from? (2003) (662)
- Functional association of cyclophilin A with HIV-1 virions (1994) (662)
- Non-heme Fe(IV)-oxo intermediates. (2007) (661)
- Minimum Information about a Biosynthetic Gene cluster. (2015) (600)
- Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA. (1991) (583)
- Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases. (1998) (581)
- New antibiotics from bacterial natural products (2006) (570)
- Harnessing the biosynthetic code: combinations, permutations, and mutations. (1998) (558)
- Glycopeptide and lipoglycopeptide antibiotics. (2005) (532)
- Polyketide and Nonribosomal Peptide Antibiotics: Modularity and Versatility (2004) (506)
- Posttranslational Modification of Proteins: Expanding Nature's Inventory (2005) (474)
- Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin. (1998) (401)
- Nature's inventory of halogenation catalysts: oxidative strategies predominate. (2006) (401)
- Natural products version 2.0: connecting genes to molecules. (2010) (400)
- Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras. (1994) (374)
- Suicide substrates: mechanism-based enzyme inactivators (1982) (368)
- Regioselectivity and stereoselectivity of androgen hydroxylations catalyzed by cytochrome P-450 isozymes purified from phenobarbital-induced rat liver. (1983) (363)
- Biological formation of pyrroles: nature's logic and enzymatic machinery. (2006) (351)
- Bacterial resistance to vancomycin: five genes and one missing hydrogen bond tell the story. (1996) (337)
- Genetically encoded short peptide tag for versatile protein labeling by Sfp phosphopantetheinyl transferase. (2005) (337)
- Localization of labile posttranslational modifications by electron capture dissociation: the case of gamma-carboxyglutamic acid. (1999) (335)
- Prospects for new antibiotics: a molecule-centered perspective (2013) (318)
- An alternative 7-ethoxyresorufin O-deethylase activity assay: a continuous visible spectrophotometric method for measurement of cytochrome P-450 monooxygenase activity. (1984) (314)
- Vancomycin assembly: nature's way. (2003) (312)
- Flavin coenzymes: at the crossroads of biological redox chemistry (1980) (307)
- Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor. (1993) (298)
- How pathogenic bacteria evade mammalian sabotage in the battle for iron (2006) (297)
- The Genetic and Molecular Basis for Sunscreen Biosynthesis in Cyanobacteria (2010) (289)
- Intracellular steps of bacterial cell wall peptidoglycan biosynthesis: enzymology, antibiotics, and antibiotic resistance. (1992) (285)
- Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis (2006) (285)
- Aminoacyl-CoAs as probes of condensation domain selectivity in nonribosomal peptide synthesis. (1999) (283)
- Halogenation strategies in natural product biosynthesis. (2008) (282)
- The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2 (2006) (279)
- The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases. (1999) (278)
- Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence. (1991) (273)
- Tailoring enzymes that modify nonribosomal peptides during and after chain elongation on NRPS assembly lines. (2001) (263)
- Active site mutants of human cyclophilin A separate peptidyl‐prolyl isomerase activity from cyclosporin A binding and calcineurin inhibition (1992) (263)
- Site-specific protein labeling by Sfp phosphopantetheinyl transferase (2006) (262)
- Potent Stimulation of SH-PTP2 Phosphatase Activity by Simultaneous Occupancy of Both SH2 Domains (*) (1995) (258)
- Peptide cyclization catalysed by the thioesterase domain of tyrocidine synthetase (2000) (255)
- Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3. (2007) (255)
- Cyclosporin A, the cyclophilin class of peptidylprolyl isomerases, and blockade of T cell signal transduction. (1992) (254)
- Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis (2005) (254)
- Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds. (2013) (254)
- Enzymes in the D-alanine branch of bacterial cell wall peptidoglycan assembly. (1989) (250)
- The evolution of gene collectives: How natural selection drives chemical innovation (2008) (249)
- Formation of cyanide from carbon 1 of 1-aminocyclopropane-1-carboxylic acid during its conversion to ethylene. (1984) (246)
- From Peptide Precursors to Oxazole and Thiazole-Containing Peptide Antibiotics: Microcin B17 Synthase (1996) (245)
- Suicide substrates, mechanism-based enzyme inactivators: recent developments. (1984) (240)
- SyrB2 in syringomycin E biosynthesis is a nonheme FeII alpha-ketoglutarate- and O2-dependent halogenase. (2005) (236)
- Drugs as materials: valuing physical form in drug discovery (2004) (235)
- Mercuric reductase. Purification and characterization of a transposon-encoded flavoprotein containing an oxidation-reduction-active disulfide. (1982) (234)
- The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis (2007) (233)
- Purification and characterization of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulfide-containing flavoprotein reductases. (1986) (229)
- Hsp90 chaperonins possess ATPase activity and bind heat shock transcription factors and peptidyl prolyl isomerases. (1993) (226)
- Post-translational modification of polyketide and nonribosomal peptide synthases. (1997) (226)
- Biomimetic synthesis and optimization of cyclic peptide antibiotics (2002) (225)
- Thiazole and oxazole peptides: biosynthesis and molecular machinery. (1999) (223)
- Flavoenzymes: versatile catalysts in biosynthetic pathways. (2013) (223)
- The structure of VibH represents nonribosomal peptide synthetase condensation, cyclization and epimerization domains (2002) (223)
- Iron acquisition in plague: modular logic in enzymatic biogenesis of yersiniabactin by Yersinia pestis. (1998) (219)
- Peptidyl-prolyl cis-trans-isomerase from Escherichia coli: a periplasmic homolog of cyclophilin that is not inhibited by cyclosporin A. (1990) (214)
- Identification of vancomycin resistance protein VanA as a D-alanine:D-alanine ligase of altered substrate specificity. (1991) (212)
- Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1. (1994) (211)
- Reconstitution and characterization of the Escherichia coli enterobactin synthetase from EntB, EntE, and EntF. (1998) (211)
- Vancomycin resistance: structure of D-alanine:D-alanine ligase at 2.3 A resolution. (1994) (210)
- Intramolecular regulation of protein tyrosine phosphatase SH-PTP1: a new function for Src homology 2 domains. (1994) (210)
- Characteristics of the cofactor requirements for the superoxide-generating NADPH oxidase of human polymorphonuclear leukocytes. (1981) (209)
- Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation (2009) (207)
- Robust in vitro activity of RebF and RebH, a two-component reductase/halogenase, generating 7-chlorotryptophan during rebeccamycin biosynthesis. (2005) (206)
- Enterobactin biosynthesis in Escherichia coli: isochorismate lyase (EntB) is a bifunctional enzyme that is phosphopantetheinylated by EntD and then acylated by EntE using ATP and 2,3-dihydroxybenzoate. (1997) (203)
- Enzymic Baeyer–Villiger Oxidations by Flavin‐Dependent Monooxygenases (1988) (201)
- Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE. (2002) (200)
- Binuclear [2Fe-2S] Clusters in the Escherichia coli SoxR Protein and Role of the Metal Centers in Transcription (*) (1995) (199)
- Oxidative Cyclization in Natural Product Biosynthesis. (2017) (198)
- Cloning, expression, and purification of human cyclophilin in Escherichia coli and assessment of the catalytic role of cysteines by site-directed mutagenesis. (1990) (198)
- Naturally occurring 5-deazaflavin coenzymes: biological redox roles (1986) (197)
- Structure of the UDP-glucosyltransferase GtfB that modifies the heptapeptide aglycone in the biosynthesis of vancomycin group antibiotics. (2001) (192)
- MurA (MurZ), the enzyme that catalyzes the first committed step in peptidoglycan biosynthesis, is essential in Escherichia coli (1995) (191)
- Chlorination by a long-lived intermediate in the mechanism of flavin-dependent halogenases. (2007) (190)
- Structure of the detoxification catalyst mercuric ion reductase from Bacillus sp. strain RC607 (1991) (189)
- Genetically encoded short peptide tags for orthogonal protein labeling by Sfp and AcpS phosphopantetheinyl transferases. (2007) (188)
- Cloning, Overproduction, and Characterization of the Escherichia coli Holo-acyl Carrier Protein Synthase (*) (1995) (187)
- Substrate-triggered formation and remarkable stability of the C-H bond-cleaving chloroferryl intermediate in the aliphatic halogenase, SyrB2. (2009) (185)
- Phenobarbital-induced rat liver cytochrome P-450. Purification and characterization of two closely related isozymic forms. (1982) (184)
- Mechanistic studies on cyclohexanone oxygenase. (1982) (183)
- The chemical versatility of natural-product assembly lines. (2008) (183)
- Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin (2009) (175)
- Combinatorial Biosynthesis of Antibiotics: Challenges and Opportunities (2002) (174)
- Bacterial carbon-phosphorus lyase: products, rates, and regulation of phosphonic and phosphinic acid metabolism (1987) (172)
- Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin. (1996) (172)
- Vancomycin resistance: decoding the molecular logic. (1993) (171)
- Assembling the glycopeptide antibiotic scaffold: The biosynthesis of from Streptomyces toyocaensis NRRL15009 (2002) (170)
- Labeling proteins with small molecules by site-specific posttranslational modification. (2004) (170)
- Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2 (2009) (169)
- Structural insights into nonribosomal peptide enzymatic assembly lines. (2009) (168)
- Cyclosporin-mediated inhibition of bovine calcineurin by cyclophilins A and B. (1992) (167)
- In vitro characterization of salmochelin and enterobactin trilactone hydrolases IroD, IroE, and Fes. (2005) (165)
- Molecular Studies on Enzymes in Chorismate Metabolism and the Enterobactin Biosynthetic Pathway (1990) (165)
- BluB cannibalizes flavin to form the lower ligand of vitamin B12 (2007) (163)
- A singular enzymatic megacomplex from Bacillus subtilis (2007) (163)
- Coumarin formation in novobiocin biosynthesis: beta-hydroxylation of the aminoacyl enzyme tyrosyl-S-NovH by a cytochrome P450 NovI. (2001) (161)
- Yersiniabactin synthetase: a four-protein assembly line producing the nonribosomal peptide/polyketide hybrid siderophore of Yersinia pestis. (2002) (161)
- Mechanism and kinetics of iron release from ferritin by dihydroflavins and dihydroflavin analogues. (1978) (161)
- Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells (1994) (158)
- Molecular cloning and sequence analysis of the complestatin biosynthetic gene cluster (2001) (157)
- Acinetobacter cyclohexanone monooxygenase: gene cloning and sequence determination (1988) (156)
- An aryl hydrocarbon hydroxylating hepatic cytochrome P-450 from the marine fish Stenotomus chrysops. (1983) (156)
- Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis. (2005) (154)
- Crystal structure of recombinant human T-cell cyclophilin A at 2.5 A resolution. (1991) (154)
- Lysine biosynthesis in Saccharomyces cerevisiae: mechanism of alpha-aminoadipate reductase (Lys2) involves posttranslational phosphopantetheinylation by Lys5. (1999) (152)
- Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis. (2006) (150)
- Human and Escherichia coli cyclophilins: sensitivity to inhibition by the immunosuppressant cyclosporin A correlates with a specific tryptophan residue. (1991) (149)
- The nonribosomal peptide synthetase HMWP2 forms a thiazoline ring during biogenesis of yersiniabactin, an iron-chelating virulence factor of Yersinia pestis. (1998) (148)
- In vitro characterization of IroB, a pathogen-associated C-glycosyltransferase. (2005) (148)
- Initiation, elongation, and termination strategies in polyketide and polypeptide antibiotic biosynthesis. (1999) (147)
- Differential functions of the two Src homology 2 domains in protein tyrosine phosphatase SH-PTP1. (1996) (146)
- In vitro biosynthesis of violacein from L-tryptophan by the enzymes VioA-E from Chromobacterium violaceum. (2006) (145)
- Mutational analysis of the epimerization domain in the initiation module PheATE of gramicidin S synthetase. (2000) (145)
- Generation of D amino acid residues in assembly of arthrofactin by dual condensation/epimerization domains. (2005) (145)
- Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway (2003) (143)
- Molecular biology of carbon-phosphorus bond cleavage. Cloning and sequencing of the phn (psiD) genes involved in alkylphosphonate uptake and C-P lyase activity in Escherichia coli B. (1990) (143)
- Biosynthesis of the Escherichia coli siderophore enterobactin: sequence of the entF gene, expression and purification of EntF, and analysis of covalent phosphopantetheine. (1991) (142)
- Dynamic thiolation–thioesterase structure of a non-ribosomal peptide synthetase (2008) (142)
- Cyclization of Fungal Nonribosomal Peptides by a Terminal Condensation-Like Domain (2012) (141)
- Conversion of L-proline to pyrrolyl-2-carboxyl-S-PCP during undecylprodigiosin and pyoluteorin biosynthesis. (2002) (140)
- Generality of peptide cyclization catalyzed by isolated thioesterase domains of nonribosomal peptide synthetases. (2001) (139)
- Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry. (2006) (138)
- Studies on the mechanism of action of D-amino acid oxidase. Evidence for removal of substrate -hydrogen as a proton. (1971) (137)
- Existence of two D-alanine:D-alanine ligases in Escherichia coli: cloning and sequencing of the ddlA gene and purification and characterization of the DdlA and DdlB enzymes. (1991) (136)
- Class I and III polyhydroxyalkanoate synthases from Ralstonia eutropha and Allochromatium vinosum: characterization and substrate specificity studies. (2001) (136)
- Halogenation of unactivated carbon centers in natural product biosynthesis: trichlorination of leucine during barbamide biosynthesis. (2006) (135)
- Assembly line enzymology by multimodular nonribosomal peptide synthetases: the thioesterase domain of E. coli EntF catalyzes both elongation and cyclolactonization. (1999) (135)
- Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics. (2000) (135)
- GliP, a multimodular nonribosomal peptide synthetase in Aspergillus fumigatus, makes the diketopiperazine scaffold of gliotoxin. (2006) (135)
- Purification and characterization of VanR and the cytosolic domain of VanS: a two-component regulatory system required for vancomycin resistance in Enterococcus faecium BM4147. (1993) (135)
- Introduction: antibiotic resistance. (2005) (134)
- Suicide substrates for the alanine racemase of Escherichia coli B. (1978) (133)
- Cloning and sequencing of Escherichia coli murZ and purification of its product, a UDP-N-acetylglucosamine enolpyruvyl transferase (1992) (131)
- Kinetics, stoichiometry, and identification of the reactive thiolate in the inactivation of UDP-GlcNAc enolpyruvoyl transferase by the antibiotic fosfomycin. (1994) (130)
- Crystal structure of vancosaminyltransferase GtfD from the vancomycin biosynthetic pathway: interactions with acceptor and nucleotide ligands. (2004) (129)
- Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides. (2001) (129)
- Holo-(Acyl Carrier Protein) Synthase and Phosphopantetheinyl Transfer in Escherichia coli * (2000) (129)
- The MerR metalloregulatory protein binds mercuric ion as a tricoordinate, metal-bridged dimer. (1990) (128)
- Cloning and characterization of the biosynthetic gene cluster for kutznerides (2007) (128)
- Enzymology of acyl chain macrocyclization in natural product biosynthesis. (2003) (127)
- Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways. (2008) (127)
- The antibiotic microcin B17 is a DNA gyrase poison: characterisation of the mode of inhibition. (2001) (127)
- Quantitation of the interaction of the immunosuppressant deoxyspergualin and analogs with Hsc70 and Hsp90. (1994) (127)
- Production, Purification, and Cleavage of Tandem Repeats of Recombinant Peptides (1994) (127)
- Cyclopiazonic acid biosynthesis in Aspergillus sp.: characterization of a reductase-like R* domain in cyclopiazonate synthetase that forms and releases cyclo-acetoacetyl-L-tryptophan. (2009) (126)
- Incorporation of glucose analogs by GtfE and GtfD from the vancomycin biosynthetic pathway to generate variant glycopeptides. (2002) (126)
- Vancomycin resistance in enterococci: reprogramming of the D-ala-D-Ala ligases in bacterial peptidoglycan biosynthesis. (2000) (125)
- Terrequinone A biosynthesis through L-tryptophan oxidation, dimerization and bisprenylation (2007) (124)
- 8-Hydroxy-5-deazaflavin-reducing hydrogenase from Methanobacterium thermoautotrophicum: 1. Purification and characterization. (1987) (123)
- Spectroscopic evidence for a high-spin Br-Fe(IV)-oxo intermediate in the alpha-ketoglutarate-dependent halogenase CytC3 from Streptomyces. (2007) (122)
- Investigating the initial steps in the biosynthesis of cyanobacterial sunscreen scytonemin. (2008) (122)
- Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes (2007) (120)
- Reconstitution and characterization of the Vibrio cholerae vibriobactin synthetase from VibB, VibE, VibF, and VibH. (2000) (120)
- Acetylenic enzyme inactivators. Inactivation of gamma-cystathionase, in vitro and in vivo, by propargylglycine. (1973) (120)
- CloQ, a prenyltransferase involved in clorobiocin biosynthesis (2003) (120)
- Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the rapamycin gene cluster. (2006) (119)
- Formation of β-Hydroxy Histidine in the Biosynthesis of Nikkomycin Antibiotics (2002) (119)
- Purification and properties of an 8-hydroxy-5-deazaflavin-reducing hydrogenase from Methanobacterium thermoautotrophicum. (1982) (119)
- Evidence for in vivo incorporation of D-lactate into peptidoglycan precursors of vancomycin-resistant enterococci (1992) (118)
- Cytochrome P-450 isozyme 1 from phenobarbital-induced rat liver: purification, characterization, and interactions with metyrapone and cytochrome b5. (1983) (117)
- Assembly of the Pseudomonas aeruginosa nonribosomal peptide siderophore pyochelin: In vitro reconstitution of aryl-4, 2-bisthiazoline synthetase activity from PchD, PchE, and PchF. (1999) (117)
- A chemoenzymatic approach to glycopeptide antibiotics. (2004) (117)
- Mercuric reductase: homology to glutathione reductase and lipoamide dehydrogenase. Iodoacetamide alkylation and sequence of the active site peptide. (1983) (116)
- FUNCTIONAL GROUP DIVERSITY IN ENZYMIC OXYGENATION REACTIONS CATALYZED BY BACTERIAL FLAVIN‐CONTAINING CYCLOHEXANONE OXYGENASE (1985) (116)
- The residual enzymatic phosphorylation activity of hexokinase II mutants is correlated with glucose repression in Saccharomyces cerevisiae. (1989) (115)
- Studies on the chirality of sulfoxidation catalyzed by bacterial flavoenzyme cyclohexanone monooxygenase and hog liver flavin adenine dinucleotide containing monooxygenase. (1982) (114)
- Biosynthetic alanine racemase of Salmonella typhimurium: purification and characterization of the enzyme encoded by the alr gene. (1986) (114)
- Staurosporine and rebeccamycin aglycones are assembled by the oxidative action of StaP, StaC, and RebC on chromopyrrolic acid. (2006) (114)
- Subcloning, expression, and purification of the enterobactin biosynthetic enzyme 2,3-dihydroxybenzoate-AMP ligase: demonstration of enzyme-bound (2,3-dihydroxybenzoyl)adenylate product. (1989) (113)
- Chemical and enzymic properties of riboflavin analogs (1978) (113)
- Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum. (2011) (113)
- Cyclophilin B trafficking through the secretory pathway is altered by binding of cyclosporin A. (1994) (113)
- Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism. (2017) (113)
- Characterization of the Cereulide NRPS α-Hydroxy Acid Specifying Modules: Activation of α-Keto Acids and Chiral Reduction on the Assembly Line (2006) (110)
- Essential PchG-Dependent Reduction in Pyochelin Biosynthesis of Pseudomonas aeruginosa (2001) (110)
- Preparation, characterization, and chemical properties of the flavin coenzyme analogues 5-deazariboflavin, 5-deazariboflavin 5'-phosphate, and 5-deazariboflavin 5'-diphosphate, 5' → 5'-adenosine ester (1976) (109)
- Flavin redox chemistry precedes substrate chlorination during the reaction of the flavin-dependent halogenase RebH. (2006) (109)
- Enabling the chemistry of life (2001) (109)
- Type II Thioesterase Restores Activity of a NRPS Module Stalled with an Aminoacyl‐S‐enzyme that Cannot Be Elongated (2004) (109)
- Insights into the chemical logic and enzymatic machinery of NRPS assembly lines. (2016) (108)
- Identification and characterization of the echinocandin B biosynthetic gene cluster from Emericella rugulosa NRRL 11440. (2012) (107)
- Biosynthesis of Yersiniabactin, a Complex Polyketide-Nonribosomal Peptide, Using Escherichia coli as a Heterologous Host (2003) (107)
- Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region. (1995) (106)
- The EntF and EntE adenylation domains of Escherichia coli enterobactin synthetase: sequestration and selectivity in acyl-AMP transfers to thiolation domain cosubstrates. (2000) (105)
- Substrate specificity for the human rotamase FKBP: a view of FK506 and rapamycin as leucine-(twisted amide)-proline mimics (1990) (105)
- A hydrogenase-linked gene in Methanobacterium thermoautotrophicum strain delta H encodes a polyferredoxin. (1989) (105)
- Assembly Line Polyketide Synthases: Mechanistic Insights and Unsolved Problems (2014) (104)
- Identification of the DNA-binding site for the phosphorylated VanR protein required for vancomycin resistance in Enterococcus faecium. (1994) (104)
- How Nature Morphs Peptide Scaffolds into Antibiotics (2009) (103)
- Structural basis for the selectivity of the external thioesterase of the surfactin synthetase (2008) (103)
- Deoxysugars in glycopeptide antibiotics: enzymatic synthesis of TDP-L-epivancosamine in chloroeremomycin biosynthesis. (2000) (103)
- Aminoacyl-SNACs as small-molecule substrates for the condensation domains of nonribosomal peptide synthetases. (2000) (102)
- Vibriobactin biosynthesis in Vibrio cholerae: VibH is an amide synthase homologous to nonribosomal peptide synthetase condensation domains. (2000) (102)
- Thermostable alanine racemase from Bacillus stearothermophilus: molecular cloning of the gene, enzyme purification, and characterization. (1986) (101)
- Nucleotide sequence of a cluster of Escherichia coli enterobactin biosynthesis genes: identification of entA and purification of its product 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase (1989) (100)
- In vitro reconstitution of the Pseudomonas aeruginosa nonribosomal peptide synthesis of pyochelin: characterization of backbone tailoring thiazoline reductase and N-methyltransferase activities. (2001) (100)
- Overexpression, purification, and characterization of VanX, a D-, D-dipeptidase which is essential for vancomycin resistance in Enterococcus faecium BM4147. (1995) (100)
- Mechanistic studies of a protonolytic organomercurial cleaving enzyme: bacterial organomercurial lyase. (1986) (100)
- A common fold for peptide synthetases cleaving ATP to ADP: glutathione synthetase and D-alanine:d-alanine ligase of Escherichia coli. (1995) (99)
- Manipulation of thiocillin variants by prepeptide gene replacement: structure, conformation, and activity of heterocycle substitution mutants. (2010) (99)
- Cytochrome P-450 isozymes from the marine teleost Stenotomus chrysops: their roles in steroid hydroxylation and the influence of cytochrome b5. (1986) (99)
- Overexpression, purification, and characterization of isochorismate synthase (EntC), the first enzyme involved in the biosynthesis of enterobactin from chorismate. (1990) (98)
- Using affinity capillary electrophoresis to determine binding stoichiometries of protein-ligand interactions. (1994) (97)
- Properties of 7,8-didemethyl-8-hydroxy-5-deazaflavins relevant to redox coenzyme function in methanogen metabolism (1984) (97)
- Carrier protein structure and recognition in polyketide and nonribosomal peptide biosynthesis. (2006) (96)
- Mutational analysis of potential zinc-binding residues in the active site of the enterococcal D-Ala-D-Ala dipeptidase VanX. (1997) (95)
- The stress response to ionizing radiation involoves c-Abl-dependent phosphorylation of SHPTP1. (1996) (95)
- Use of a site-directed triple mutant to trap intermediates: demonstration that the flavin C(4a)-thiol adduct and reduced flavin are kinetically competent intermediates in mercuric ion reductase. (1990) (95)
- Phosphorylation of Ser-42 and Ser-59 in the N-terminal region of the tyrosine kinase p56lck. (1993) (94)
- Ability of Streptomyces spp. acyl carrier proteins and coenzyme A analogs to serve as substrates in vitro for E. coli holo-ACP synthase. (1997) (94)
- Oxidase domains in epothilone and bleomycin biosynthesis: thiazoline to thiazole oxidation during chain elongation. (2003) (93)
- Characterization of the surfactin synthetase C-terminal thioesterase domain as a cyclic depsipeptide synthase. (2002) (93)
- Overexpression, purification, and mechanistic study of UDP-N-acetylenolpyruvylglucosamine reductase. (1993) (93)
- Acetyltransfer precedes uridylyltransfer in the formation of UDP-N-acetylglucosamine in separable active sites of the bifunctional GlmU protein of Escherichia coli. (1996) (93)
- D-Alanyl-D-alanine ligases and the molecular mechanism of vancomycin resistance (1992) (92)
- Two alanine racemase genes in Salmonella typhimurium that differ in structure and function (1983) (92)
- Kinetics of p56lck and p60src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonance. (1993) (91)
- Organomercurial lyase and mercuric ion reductase: nature's mercury detoxification catalysts (1990) (91)
- Cloning, sequence determination, and expression of the genes encoding the subunits of the nickel-containing 8-hydroxy-5-deazaflavin reducing hydrogenase from Methanobacterium thermoautotrophicum delta H. (1990) (91)
- Cyclization of backbone-substituted peptides catalyzed by the thioesterase domain from the tyrocidine nonribosomal peptide synthetase. (2001) (90)
- Catabolic alanine racemase from Salmonella typhimurium: DNA sequence, enzyme purification, and characterization. (1984) (89)
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- Nickel and iron EXAFS of F420-reducing hydrogenase from Methanobacterium thermoautotrophicum (1984) (77)
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- p-Aminobenzoate synthesis in Escherichia coli: purification and characterization of PabB as aminodeoxychorismate synthase and enzyme X as aminodeoxychorismate lyase. (1990) (74)
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- Biosynthetic thiolase from Zoogloea ramigera. III. Isolation and characterization of the structural gene. (1987) (71)
- Crystallographic trapping in the rebeccamycin biosynthetic enzyme RebC (2007) (71)
- Homologous metalloregulatory proteins from both gram-positive and gram-negative bacteria control transcription of mercury resistance operons (1989) (71)
- Structural Analysis of an Open Active Site Conformation of Nonheme Iron Halogenase CytC3 (2009) (70)
- Cross-talk between the Histidine Protein Kinase VanS and the Response Regulator PhoB (1995) (70)
- Transcriptional regulation of the Enterococcus faecium BM4147 vancomycin resistance gene cluster by the VanS-VanR two-component regulatory system in Escherichia coli K-12 (1997) (70)
- Homologs of the vancomycin resistance D-Ala-D-Ala dipeptidase VanX in Streptomyces toyocaensis, Escherichia coli and Synechocystis: attributes of catalytic efficiency, stereoselectivity and regulation with implications for function. (1998) (69)
- Cyclophilin residues that affect noncompetitive inhibition of the protein serine phosphatase activity of calcineurin by the cyclophilin.cyclosporin A complex. (1994) (69)
- In vitro and in vivo functional characterization of bovine vitamin K-dependent gamma-carboxylase expressed in Chinese hamster ovary cells. (1993) (68)
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- Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus (2010) (68)
- The structure of the substrate-free form of MurB, an essential enzyme for the synthesis of bacterial cell walls. (1996) (66)
- Non-uniformly sampled double-TROSY hNcaNH experiments for NMR sequential assignments of large proteins. (2006) (66)
- AknT is an activating protein for the glycosyltransferase AknS in L-aminodeoxysugar transfer to the aglycone of aclacinomycin A. (2005) (66)
- Rotational resonance determination of the structure of an enzyme-inhibitor complex: phosphorylation of an (aminoalkyl)phosphinate inhibitor of D-alanyl-D-alanine ligase by ATP. (1990) (66)
- The lyngbyatoxin biosynthetic assembly line: chain release by four-electron reduction of a dipeptidyl thioester to the corresponding alcohol. (2007) (65)
- Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A. (1994) (65)
- The loading module of mycosubtilin: an adenylation domain with fatty acid selectivity. (2007) (65)
- Kinetic evidence for the formation of D-alanyl phosphate in the mechanism of D-alanyl-D-alanine ligase. (1990) (65)
- A protein interaction surface in nonribosomal peptide synthesis mapped by combinatorial mutagenesis and selection. (2006) (65)
- A systematic investigation of the synthetic utility of glycopeptide glycosyltransferases. (2005) (65)
- Identification of the thiazolyl peptide GE37468 gene cluster from Streptomyces ATCC 55365 and heterologous expression in Streptomyces lividans (2011) (65)
- Substrate specificities of catalytic fragments of protein tyrosine phosphatases (HPTPβ, LAR, and CD45) toward phosphotyrosylpeptide substrates and thiophosphotyrosylated peptides as inhibitors (1993) (65)
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- Genetic interception and structural characterization of thiopeptide cyclization precursors from Bacillus cereus. (2010) (63)
- Effects of cyclosporin A and FK506 on Fc epsilon receptor type I-initiated increases in cytokine mRNA in mouse bone marrow-derived progenitor mast cells: resistance to FK506 is associated with a deficiency in FK506-binding protein FKBP12. (1992) (63)
- Nine enzymes are required for assembly of the pacidamycin group of peptidyl nucleoside antibiotics. (2011) (63)
- Purification of an alanine racemase from Streptococcus faecalis and analysis of its inactivation by (1-aminoethyl)phosphonic acid enantiomers. (1985) (62)
- Biosynthesis of Piperazic Acid via N5‐Hydroxy‐Ornithine in Kutzneria spp. 744 (2012) (62)
- A flavin-dependent halogenase catalyzes the chlorination step in the biosynthesis of Dictyostelium differentiation-inducing factor 1 (2010) (62)
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- In vivo characterization of the type A and B vancomycin-resistant enterococci (VRE) VanRS two-component systems in Escherichia coli: a nonpathogenic model for studying the VRE signal transduction pathways. (1998) (62)
- Expression, purification, and characterization of HMWP2, a 229 kDa, six domain protein subunit of Yersiniabactin synthetase. (2000) (61)
- Stereospecific synthesis of threo- and erythro-beta-hydroxyglutamic acid during kutzneride biosynthesis. (2009) (61)
- Enzymatic Generation of the Antimetabolite γ,γ-Dichloroaminobutyrate by NRPS and Mononuclear Iron Halogenase Action in a Streptomycete (2006) (61)
- Dithiolopyrrolones: biosynthesis, synthesis, and activity of a unique class of disulfide-containing antibiotics. (2014) (61)
- Three siderophores from one bacterial enzymatic assembly line. (2009) (61)
- Biosynthetic tailoring of microcin E492m: post-translational modification affords an antibacterial siderophore-peptide conjugate. (2007) (61)
- Enzymatic Baeyer-Villiger type oxidations of ketones catalyzed by cyclohexanone oxygenase (1989) (61)
- Biosynthetic thiolase from zoogloea ramigera. I. Preliminary characterization and analysis of proton transfer reaction. (1987) (60)
- Three ring posttranslational circuses: insertion of oxazoles, thiazoles, and pyridines into protein-derived frameworks. (2012) (60)
- ATP-dependent inactivation and slow binding inhibition of Salmonella typhimurium D-alanine:D-alanine ligase (ADP) by (aminoalkyl)phosphinate and aminophosphonate analogues of D-alanine. (1988) (60)
- Isolation, cloning, and sequencing of the Salmonella typhimurium ddlA gene with purification and characterization of its product, D-alanine:D-alanine ligase (ADP forming). (1988) (60)
- How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic (2009) (59)
- Single-cell FRET imaging of transferrin receptor trafficking dynamics by Sfp-catalyzed, site-specific protein labeling. (2005) (59)
- Biosynthetic Thiolase from Zoogloea ramigera (1987) (59)
- Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry. (2006) (59)
- 1-Aminocyclopropanephosphonate: time-dependent inactivation of 1-aminocyclopropanecarboxylate deaminase and Bacillus stearothermophilus alanine racemase by slow dissociation behavior. (1987) (59)
- Structural elements of an NRPS cyclization domain and its intermodule docking domain (2016) (59)
- Biosynthetic thiolase from Zoogloea ramigera. Evidence for a mechanism involving Cys-378 as the active site base. (1991) (58)
- The formation of dihydrodiols by the chemical or enzymic oxidation of benz[a] anthracene and 7,12-dimethylbenz[a] anthracene. (1978) (58)
- Flavin and 5-deazaflavin photosensitized cleavage of thymine dimer: a model of in vivo light-requiring DNA repair (1984) (58)
- Poly-(R)-3-hydroxybutyrate (PHB) biosynthesis: mechanistic studies on the biological Claisen condensation catalyzed by β-ketoacyl thiolase (1989) (58)
- Nonenzymatic oxidative steps accompanying action of the cytochrome P450 enzymes StaP and RebP in the biosynthesis of staurosporine and rebeccamycin. (2007) (58)
- Dissection of the EntF condensation domain boundary and active site residues in nonribosomal peptide synthesis. (2003) (58)
- Molecular and biochemical comparison of the 70-kDa heat shock proteins of Trypanosoma cruzi. (1994) (58)
- Vinylglycine and proparglyglycine: complementary suicide substrates for L-amino acid oxidase and D-amino acid oxidase. (1976) (58)
- Genome-wide high-throughput mining of natural-product biosynthetic gene clusters by phage display. (2007) (58)
- The loading module of rifamycin synthetase is an adenylation-thiolation didomain with substrate tolerance for substituted benzoates. (2001) (58)
- Characterization of a new tailoring domain in polyketide biogenesis: the amine transferase domain of MycA in the mycosubtilin gene cluster. (2005) (58)
- Inactivation of a flavoprotein, lactate oxidase, by an acetylenic substrate. (1972) (58)
- Short pathways to complexity generation: fungal peptidyl alkaloid multicyclic scaffolds from anthranilate building blocks. (2013) (57)
- EcdGHK are three tailoring iron oxygenases for amino acid building blocks of the echinocandin scaffold. (2013) (57)
- Protein assembly line components in prodigiosin biosynthesis: characterization of PigA,G,H,I,J. (2006) (57)
- Loading peptidyl-coenzyme A onto peptidyl carrier proteins: a novel approach in characterizing macrocyclization by thioesterase domains. (2003) (57)
- tRNA-dependent peptide bond formation by the transferase PacB in biosynthesis of the pacidamycin group of pentapeptidyl nucleoside antibiotics (2011) (57)
- Streptomyces clavuligerus HlmI is an intramolecular disulfide-forming dithiol oxidase in holomycin biosynthesis. (2011) (56)
- Reconstitution of Escherichia coli photolyase with flavins and flavin analogues. (1990) (56)
- Aminoacyl-S-enzyme intermediates in beta-hydroxylations and alpha,beta-desaturations of amino acids in peptide antibiotics. (2001) (56)
- Antimicrobials (2005) (56)
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- Biosynthesis of (-)-(1S,2R)-allocoronamic acyl thioester by an Fe(II)-dependent halogenase and a cyclopropane-forming flavoprotein. (2008) (55)
- Enzyme-catalyzed redox reactions with the flavin analogues 5-deazariboflavin, 5-deazariboflavin 5'-phosphte, and 5-deazariboflavin 5'-diphosphate, 5' leads to 5'-adenosine ester. (1976) (55)
- NRPS Substrate Promiscuity Diversifies the Xenematides (2011) (55)
- Mutagenesis of the N- and C-terminal cysteine pairs of Tn501 mercuric ion reductase: consequences for bacterial detoxification of mercurials. (1989) (55)
- Purification of glutathionylspermidine and trypanothione synthetases from crithidia fasciculata (1992) (55)
- Elucidating the substrate specificity and condensation domain activity of FkbP, the FK520 pipecolate-incorporating enzyme. (2005) (55)
- beta-Hydroxylation of the aspartyl residue in the phytotoxin syringomycin E: characterization of two candidate hydroxylases AspH and SyrP in Pseudomonas syringae. (2008) (55)
- Active site of mercuric reductase resides at the subunit interface and requires Cys135 and Cys140 from one subunit and Cys558 and Cys559 from the adjacent subunit: evidence from in vivo and in vitro heterodimer formation. (1990) (55)
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- Characteristics of beta, beta-difluoroalanine and beta, beta, beta -trifluoroalanine as suicide substrates for Escherichia coli B alanine racemase. (1981) (54)
- Characterization of cyclo-acetoacetyl-L-tryptophan dimethylallyltransferase in cyclopiazonic acid biosynthesis: substrate promiscuity and site directed mutagenesis studies. (2009) (54)
- Stereochemical course of enzymatic enolpyruvyl transfer and catalytic conformation of the active site revealed by the crystal structure of the fluorinated analogue of the reaction tetrahedral intermediate bound to the active site of the C115A mutant of MurA. (1998) (54)
- A transglutaminase homologue as a condensation catalyst in antibiotic assembly lines (2007) (54)
- Identification of amino acids in the gamma-carboxylation recognition site on the propeptide of prothrombin. (1990) (53)
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- In vivo processing and antibiotic activity of microcin B17 analogs with varying ring content and altered bisheterocyclic sites. (1999) (53)
- Inactivation of the Pseudomonas striata broad specificity amino acid racemase by D and L isomers of beta-substituted alanines: kinetics, stoichiometry, active site peptide, and mechanistic studies. (1984) (53)
- The posttranslational modification cascade to the thiopeptide berninamycin generates linear forms and altered macrocyclic scaffolds (2013) (53)
- Synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin and confirmation of its identity with the deazaisoalloxazine chromophore of Methanobacterium redox coenzyme F420 (1979) (53)
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- The structural basis for induction of VanB resistance. (2002) (53)
- Epimerization of an L-cysteinyl to a D-cysteinyl residue during thiazoline ring formation in siderophore chain elongation by pyochelin synthetase from Pseudomonas aeruginosa. (2003) (52)
- The leader peptide is essential for the post‐translational modification of the DNA‐gyrase inhibitor microcin B17 (1997) (52)
- Epothilone C macrolactonization and hydrolysis are catalyzed by the isolated thioesterase domain of epothilone polyketide synthase. (2003) (52)
- Purification and characterization of a soluble catalytic fragment of the human transmembrane leukocyte antigen related (LAR) protein tyrosine phosphatase from an Escherichia coli expression system. (1991) (52)
- An eight residue fragment of an acyl carrier protein suffices for post-translational introduction of fluorescent pantetheinyl arms in protein modification in vitro and in vivo. (2008) (52)
- Kinetic characterization of wild-type and S229A mutant MurB: evidence for the role of Ser 229 as a general acid. (1997) (52)
- Overexpression, purification, and characterization of SHPTP1, a Src homology 2-containing protein-tyrosine-phosphatase. (1993) (52)
- A three enzyme pathway for 2-amino-3-hydroxycyclopent-2-enone formation and incorporation in natural product biosynthesis. (2010) (52)
- Roles of FAD and 8-hydroxy-5-deazaflavin chromophores in photoreactivation by Anacystis nidulans DNA photolyase. (1992) (51)
- Biosynthetic Chlorination of the Piperazate Residue in Kutzneride Biosynthesis by KthP (2011) (51)
- The thioesterase domain from a nonribosomal peptide synthetase as a cyclization catalyst for integrin binding peptides (2002) (51)
- D-Alanyl-D-Lactate and D-Alanyl-D-Alanine Synthesis by D-Alanyl-D-Alanine Ligase from Vancomycin-resistant Leuconostoc mesenteroides EFFECTS OF A PHENYLALANINE 261 TO TYROSINE MUTATION* (1997) (51)
- Aminobenzoates as building blocks for natural product assembly lines. (2012) (51)
- Biosynthetic alr alanine racemase from Salmonella typhimurium: DNA and protein sequence determination. (1986) (51)
- Factor 390 chromophores: phosphodiester between AMP or GMP and methanogen factor 420. (1985) (51)
- Modification of Ser59 in the unique N-terminal region of tyrosine kinase p56lck regulates specificity of its Src homology 2 domain. (1995) (50)
- Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus. (2011) (50)
- ATP/GTP hydrolysis is required for oxazole and thiazole biosynthesis in the peptide antibiotic microcin B17. (1998) (50)
- Kinetic characterization of the carbon monoxide-acetyl-CoA (carbonyl group) exchange activity of the acetyl-CoA synthesizing CO dehydrogenase from Clostridium thermoaceticum. (1988) (50)
- [45] Suicide substrates for flavoprotein enzymes (1978) (49)
- A chemocentric view of the natural product inventory. (2015) (49)
- Chemical logic and enzymatic machinery for biological assembly of peptidyl nucleoside antibiotics. (2011) (49)
- Enzymes of vancomycin resistance: the structure of D-alanine-D-lactate ligase of naturally resistant Leuconostoc mesenteroides. (2000) (49)
- Expression of Trypanosoma congolense trypanothione reductase in Escherichia coli: overproduction, purification, and characterization. (1989) (49)
- p-aminobenzoate synthesis in Escherichia coli: kinetic and mechanistic characterization of the amidotransferase PabA. (1992) (48)
- Localized protein interaction surfaces on the EntB carrier protein revealed by combinatorial mutagenesis and selection. (2006) (48)
- Directed evolution of aryl carrier proteins in the enterobactin synthetase (2007) (48)
- Catalytic domains of the LAR and CD45 protein tyrosine phosphatases from Escherichia coli expression systems: purification and characterization for specificity and mechanism. (1992) (48)
- Mechanism-based inactivation of pig heart L-alanine transaminase by L-propargylglycine. Half-site reactivity. (1980) (48)
- Investigations of the MceIJ-catalyzed posttranslational modification of the microcin E492 C-terminus: linkage of ribosomal and nonribosomal peptides to form "trojan horse" antibiotics. (2008) (48)
- X-ray crystal structures of the S229A mutant and wild-type MurB in the presence of the substrate enolpyruvyl-UDP-N-acetylglucosamine at 1.8-A resolution. (1997) (48)
- Mutagenesis of the cysteines in the metalloregulatory protein MerR indicates that a metal-bridged dimer activates transcription. (1989) (48)
- The LIM region of a presumptive Caenorhabditis elegans transcription factor is an iron-sulfur- and zinc-containing metallodomain. (1991) (48)
- Inhibition of alanine racemase by alanine phosphonate: detection of an imine linkage to pyridoxal 5'-phosphate in the enzyme-inhibitor complex by solid-state 15N nuclear magnetic resonance. (1988) (47)
- Active site-directed inactivation of cystathionine gamma-synthetase and glutamic pyruvic transaminase by propargylglycine. (1975) (47)
- Co‐ordination between BrlA regulation and secretion of the oxidoreductase FmqD directs selective accumulation of fumiquinazoline C to conidial tissues in Aspergillus fumigatus (2014) (47)
- Divalent ion effects and insights into the catalytic mechanism of protein tyrosine kinase Csk. (1997) (47)
- Characterization of a regiospecific epivancosaminyl transferase GtfA and enzymatic reconstitution of the antibiotic chloroeremomycin. (2004) (47)
- Peptidyl thiophenols as substrates for nonribosomal peptide cyclases. (2004) (47)
- Selectivity of the yersiniabactin synthetase adenylation domain in the two-step process of amino acid activation and transfer to a holo-carrier protein domain. (2000) (47)
- Substrate recognition and selection by the initiation module PheATE of gramicidin S synthetase. (2001) (47)
- Nickel tetrapyrrole cofactor F430: comparison of the forms bound to methyl S-coenzyme M reductase and protein free in cells of Methanobacterium thermoautotrophicum .DELTA.H (1984) (47)
- Heterocycle formation in vibriobactin biosynthesis: alternative substrate utilization and identification of a condensed intermediate. (2001) (46)
- AknK is an L-2-deoxyfucosyltransferase in the biosynthesis of the anthracycline aclacinomycin A. (2004) (46)
- Demonstration of carbon-carbon bond cleavage of acetyl coenzyme A by using isotopic exchange catalyzed by the CO dehydrogenase complex from acetate-grown Methanosarcina thermophila (1991) (46)
- Role of the microcin B17 propeptide in substrate recognition: solution structure and mutational analysis of McbA1-26. (1998) (46)
- Toward efficient analysis of <70 kDa proteins with 100% sequence coverage (2001) (46)
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- Competitive inhibition of calcineurin phosphatase activity by its autoinhibitory domain. (1996) (46)
- Assembly of asperlicin peptidyl alkaloids from anthranilate and tryptophan: a two-enzyme pathway generates heptacyclic scaffold complexity in asperlicin E. (2012) (46)
- Complexity generation in fungal peptidyl alkaloid biosynthesis: a two-enzyme pathway to the hexacyclic MDR export pump inhibitor ardeemin. (2013) (46)
- Studies on the elimination reaction of D-amino acid oxidase with -amino- -chlorobutyrate. Further evidence for abstraction of substrate -hydrogen as a proton. (1973) (45)
- Evidence for a monomeric structure of nonribosomal Peptide synthetases. (2002) (45)
- Inactivation of bacterial D-amino acid transaminases by the olefinic amino acid D-vinylglycine. (1977) (45)
- Substrate analogues as mechanistic probes of methyl-S-coenzyme M reductase. (1987) (45)
- 8-Hydroxy-5-deazaflavin-reducing hydrogenase from Methanobacterium thermoautotrophicum: 2. Kinetic and hydrogen-transfer studies. (1987) (44)
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- Mechanism of inactivation of alanine racemase by beta, beta, beta-trifluoroalanine. (1989) (44)
- Cloning and Characterization of the Two Enzymes Responsible for Trypanothione Biosynthesis in Crithidia fasciculata * (1998) (44)
- Vitamin K-dependent carboxylation. In vitro modification of synthetic peptides containing the gamma-carboxylation recognition site. (1989) (44)
- In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides. (2005) (44)
- Localization of the affinity peptide-substrate inactivator site on recombinant vitamin K-dependent carboxylase. (1994) (44)
- Gain of D-alanyl-D-lactate or D-lactyl-D-alanine synthetase activities in three active-site mutants of the Escherichia coli D-alanyl-D-alanine ligase B. (1996) (44)
- Directed mutagenesis of the redox-active disulfide in the flavoenzyme mercuric ion reductase. (1985) (43)
- In vitro characterization of DNA gyrase inhibition by microcin B17 analogs with altered bisheterocyclic sites (2001) (43)
- Andrimid producers encode an acetyl-CoA carboxyltransferase subunit resistant to the action of the antibiotic (2008) (43)
- The versatility of phosphoenolpyruvate and its vinyl ether products in biosynthesis. (1996) (43)
- Time-dependent inhibition of Bacillus stearothermophilus alanine racemase by (1-aminoethyl)phosphonate isomers by isomerization to noncovalent slowly dissociating enzyme-(1-aminoethyl)phosphonate complexes. (1986) (43)
- The Role of the Catalytic Base in the Protein Tyrosine Kinase Csk (*) (1995) (43)
- One-and two-electron redox chemistry of 1-carba-1-deazariboflavin. (1977) (43)
- Enzymatic tailoring of enterobactin alters membrane partitioning and iron acquisition. (2006) (43)
- Mechanistic studies on the rat kidney flavoenzyme L-alpha-hydroxy acid oxidase. (1975) (43)
- Chemoenzymatic route to macrocyclic hybrid peptide/polyketide-like molecules. (2003) (43)
- Unraveling terminal C-domain-mediated condensation in fungal biosynthesis of imidazoindolone metabolites. (2011) (42)
- The Violacein Biosynthetic Enzyme VioE Shares a Fold with Lipoprotein Transporter Proteins* (2008) (42)
- Stereochemical Studies on the Reactions Catalyzed by the PLP-Dependent Enzyme 1-Aminocyclopropane-1-carboxylate Deaminase (1984) (42)
- Purification and properties of dihydroorotate oxidase from Crithidia fasciculata and Trypanosoma brucei. (1983) (42)
- Dissection of Glutathionylspermidine Synthetase/Amidase from Escherichia coli into Autonomously Folding and Functional Synthetase and Amidase Domains* (1997) (42)
- Mutational analysis of posttranslational heterocycle biosynthesis in the gyrase inhibitor microcin B17: distance dependence from propeptide and tolerance for substitution in a GSCG cyclizable sequence. (1998) (41)
- (1-Aminoethyl)boronic acid: a novel inhibitor for Bacillus stearothermophilus alanine racemase and Salmonella typhimurium D-alanine:D-alanine ligase (ADP-forming). (1989) (41)
- Macrolactamization of glycosylated peptide thioesters by the thioesterase domain of tyrocidine synthetase. (2004) (41)
- Cloning and characterization of a photolyase gene from the cyanobacterium Anacystis nidulans. (1988) (41)
- Bacterial resistance to vancomycin: overproduction, purification, and characterization of VanC2 from Enterococcus casseliflavus as a D-Ala-D-Ser ligase. (1997) (41)
- The NADPH-linked acetoacetyl-CoA reductase from Zoogloea ramigera. Characterization and mechanistic studies of the cloned enzyme over-produced in Escherichia coli. (1988) (41)
- Stoichiometry and specificity of in vitro phosphopantetheinylation and aminoacylation of the valine-activating module of surfactin synthetase. (1998) (41)
- C-terminal cysteines of Tn501 mercuric ion reductase. (1992) (40)
- Mechanistic studies on trans-2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase (Ent A) in the biosynthesis of the iron chelator enterobactin. (1990) (40)
- Structure-Activity Relationship and Molecular Mechanics Reveal the Importance of Ring Entropy in the Biosynthesis and Activity of a Natural Product. (2017) (40)
- Characterization of the aminocarboxycyclopropane-forming enzyme CmaC. (2007) (40)
- Kinetic studies on the inactivation of L-lactate oxidase by [the acetylenic suicide substrate] 2-hydroxy-3-butynoate. (1976) (40)
- Two-electron reduced mercuric reductase binds Hg(II) to the active site dithiol but does not catalyze Hg(II) reduction. (1986) (40)
- Initial characterization of novobiocic acid noviosyl transferase activity of NovM in biosynthesis of the antibiotic novobiocin. (2003) (40)
- Localization of the factor IX propeptide binding site on recombinant vitamin K dependent carboxylase using benzoylphenylalanine photoaffinity peptide inactivators. (1995) (40)
- Mutagenesis of the redox-active disulfide in mercuric ion reductase: catalysis by mutant enzymes restricted to flavin redox chemistry. (1989) (40)
- The State of the Art of Chemical Biology (2009) (40)
- Interdomain communication between the thiolation and thioesterase domains of EntF explored by combinatorial mutagenesis and selection. (2006) (40)
- Mass spectrometric interrogation of thioester-bound intermediates in the initial stages of epothilone biosynthesis. (2004) (40)
- Non‐Heme Fe(IV)—Oxo Intermediates (2007) (40)
- Characterization of CmaA, an Adenylation-Thiolation Didomain Enzyme Involved in the Biosynthesis of Coronatine (2004) (39)
- The structure of the covalent flavin adduct formed between lactate oxidase and the suicide substrate 2-hydroxy-3-butynoate. (1976) (39)
- The ATP-dependent amide ligases DdaG and DdaF assemble the fumaramoyl-dipeptide scaffold of the dapdiamide antibiotics. (2009) (39)
- Phagemid encoded small molecules for high throughput screening of chemical libraries. (2004) (39)
- Tandem heterocyclization activity of the multidomain 230 kDa HMWP2 subunit of Yersinia pestis yersiniabactin synthetase: interaction of the 1-1382 and 1383-2035 fragments. (1999) (39)
- A Backup Plan for Self‐Protection: S‐Methylation of Holomycin Biosynthetic Intermediates in Streptomyces clavuligerus (2012) (39)
- Structural characterization of enterobactin hydrolase IroE. (2006) (39)
- 83‐Kilodalton heat shock proteins of trypanosomes are potent peptide‐stimulated ATPases (1992) (39)
- Nickel and iron EXAFS of carbon monoxide dehydrogenase from Clostridium thermoaceticum strain DSM (1988) (39)
- Total Biosynthesis: in vitro Reconstitution of Polyketide and Nonribosomal Peptide Pathways (2008) (39)
- Determinants for differential effects on D-Ala-D-lactate vs D-Ala-D-Ala formation by the VanA ligase from vancomycin-resistant enterococci. (1999) (38)
- Identification of phenylalanine 3-hydroxylase for meta-tyrosine biosynthesis. (2011) (38)
- Stereochemical studies of 8-hydroxy-5-deazaflavin-dependent NADP+ reductase from Methanococcus vannielii. (1980) (38)
- PchC Thioesterase Optimizes Nonribosomal Biosynthesis of the Peptide Siderophore Pyochelin in Pseudomonas aeruginosa (2004) (38)
- Heterologous expression in Escherichia coli of the first module of the nonribosomal peptide synthetase for chloroeremomycin, a vancomycin-type glycopeptide antibiotic. (2000) (37)
- Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity. (1997) (37)
- Investigation of anticapsin biosynthesis reveals a four-enzyme pathway to tetrahydrotyrosine in Bacillus subtilis. (2010) (37)
- Utilization of Enzymatically Phosphopantetheinylated Acyl Carrier Proteins and Acetyl−Acyl Carrier Proteins by the Actinorhodin Polyketide Synthase† (1997) (37)
- Rat kidney L-alpha-hydroxy acid oxidase: isolation of enzyme with one flavine coenzyme per two subunits. (1975) (37)
- Flavin analogs as mechanistic probes of adrenodoxin reductase-dependent electron transfer to the cholesterol side chain cleavage cytochrome P-450 of the adrenal cortex. (1980) (37)
- Mechanisms of active transport in isolated bacterial membrane vesicles. X. Inactivation of D-lactate dehydrogenase and D-lactate dehydrogenase-coupled transport in Escherichia coli membrane vesicles by an acetylenic substrate. (1972) (37)
- Holo-[acyl-carrier-protein] synthase of Escherichia coli. (1997) (37)
- Expressed protein ligation to probe regiospecificity of heterocyclization in the peptide antibiotic microcin B17. (1999) (37)
- Biosynthesis of epothilone intermediates with alternate starter units: engineering polyketide-nonribosomal interfaces. (2003) (36)
- Escherichia coli glyoxalate carboligase. Properties and reconstitution with 5-deazaFAD and 1,5-dihydrodeazaFADH2. (1976) (36)
- Gatekeeping versus promiscuity in the early stages of the andrimid biosynthetic assembly line. (2008) (36)
- Vitamin K-dependent carboxylase: affinity purification from bovine liver by using a synthetic propeptide containing the gamma-carboxylation recognition site. (1989) (36)
- A phosphoenzyme intermediary in phosphoglycerate kinase action. (1971) (36)
- Mutational analysis of active-site residues of the enterococcal D-ala-D-Ala dipeptidase VanX and comparison with Escherichia coli D-ala-D-Ala ligase and D-ala-D-Ala carboxypeptidase VanY. (1999) (36)
- Formation of beta-hydroxy histidine in the biosynthesis of nikkomycin antibiotics. (2002) (36)
- Characterization of EntF as a serine‐activating enzyme (1992) (36)
- Generation of thiocillin ring size variants by prepeptide gene replacement and in vivo processing by Bacillus cereus. (2012) (36)
- Phosphinate analogs of D-, D-dipeptides: slow-binding inhibition and proteolysis protection of VanX, a D-, D-dipeptidase required for vancomycin resistance in Enterococcus faecium. (1995) (36)
- Purification, priming, and catalytic acylation of carrier protein domains in the polyketide synthase and nonribosomal peptidyl synthetase modules of the HMWP1 subunit of yersiniabactin synthetase. (2001) (35)
- Fragmentative and stereochemical isomerization probes for homolytic carbon to phosphorus bond scission catalyzed by bacterial carbon-phosphorus lyase (1987) (35)
- The Pseudomonas aeruginosa antimetabolite L -2-amino-4-methoxy-trans-3-butenoic acid (AMB) is made from glutamate and two alanine residues via a thiotemplate-linked tripeptide precursor (2015) (35)
- Biosynthetic thiolase from Zoogloea ramigera. Mutagenesis of the putative active-site base Cys-378 to Ser-378 changes the partitioning of the acetyl S-enzyme intermediate. (1992) (35)
- DpgC is a metal- and cofactor-free 3,5-dihydroxyphenylacetyl-CoA 1,2-dioxygenase in the vancomycin biosynthetic pathway. (2004) (35)
- Enzymatic assembly of epothilones: the EpoC subunit and reconstitution of the EpoA-ACP/B/C polyketide and nonribosomal peptide interfaces. (2002) (34)
- Enzymatic reduction of 5-deazariboflavine from reduced nicotinamide adenine dinucleotide by direct hydrogen transfer. (1974) (34)
- Propeptide and glutamate-containing substrates bound to the vitamin K-dependent carboxylase convert its vitamin K epoxidase function from an inactive to an active state. (1997) (34)
- Profactor IX Propeptide and Glutamate Substrate Binding Sites on the Vitamin K-dependent Carboxylase Identified by Site-directed Mutagenesis* (1996) (34)
- SyrB 2 in syringomycin E biosynthesis is a nonheme FeII-ketoglutarate-and O 2-dependent halogenase (2005) (34)
- Nickel enzymes. (1987) (34)
- Communication between the active sites in dimeric mercuric ion reductase: an alternating sites hypothesis for catalysis. (1991) (34)
- SylC catalyzes ureido-bond formation during biosynthesis of the proteasome inhibitor syringolin A. (2009) (34)
- Characterization of SyrC, an aminoacyltransferase shuttling threonyl and chlorothreonyl residues in the syringomycin biosynthetic assembly line. (2007) (34)
- Repurposing libraries of eukaryotic protein kinase inhibitors for antibiotic discovery (2009) (33)
- The phosphopeptide-binding specificity of Src family SH2 domains. (1994) (33)
- Kinetics and regioselectivity of peptide-to-heterocycle conversions by microcin B17 synthetase. (1998) (33)
- Biochemistry of the Cyclopropyl Group (2005) (33)
- Stereochemistry of the enzymatic ring opening of 1-aminocyclopropanecarboxylic acid (1984) (33)
- Mechanistic studies on reactions of bacterial methionine gamma-lyase with olefinic amino acids. (1981) (33)
- Determination of all NOes in 1H–13C–Me-ILV-U−2H–15N Proteins with Two Time-Shared Experiments (2006) (33)
- Hybrid nonribosomal peptide-polyketide interfaces in epothilone biosynthesis: minimal requirements at N and C termini of EpoB for elongation. (2004) (33)
- Isolation and structural elucidation of a tetrahedral intermediate in the UDP-N-acetylglucosamine enolpyruvoyl transferase enzymic pathway (1993) (33)
- The nonribosomal peptide synthetase enzyme DdaD tethers N(β)-fumaramoyl-l-2,3-diaminopropionate for Fe(II)/α-ketoglutarate-dependent epoxidation by DdaC during dapdiamide antibiotic biosynthesis. (2010) (32)
- Biological matching of chemical reactivity: pairing indole nucleophilicity with electrophilic isoprenoids. (2014) (32)
- Electron microscopy of nickel-containing methanogenic enzymes: methyl reductase and F420-reducing hydrogenase (1987) (32)
- An unusual role for a mobile flavin in StaC-like indolocarbazole biosynthetic enzymes. (2012) (31)
- Mechanism-based inactivation of the flavoenzyme cyclohexane oxygenase during oxygenation of cyclic thiol ester substrates (1987) (31)
- Functional analysis of an interspecies chimera of acyl carrier proteins indicates a specialized domain for protein recognition (1998) (31)
- Dichlorination and Bromination of a Threonyl‐S‐Carrier Protein by the Non‐heme FeII Halogenase SyrB2 (2006) (31)
- Utilization of alternate substrates by the first three modules of the epothilone synthetase assembly line. (2002) (31)
- A ketoreductase domain in the PksJ protein of the bacillaene assembly line carries out both α- and β-ketone reduction during chain growth (2008) (31)
- Mechanistic studies of the coenzyme F420 reducing formate dehydrogenase from Methanobacterium formicicum. (1986) (31)
- Assembly of dimeric variants of coumermycins by tandem action of the four biosynthetic enzymes CouL, CouM, CouP, and NovN. (2004) (31)
- Characterization of rhodosaminyl transfer by the AknS/AknT glycosylation complex and its use in reconstituting the biosynthetic pathway of aclacinomycin A. (2007) (31)
- Letter: Stereospecific synthesis of isotopically labeled serine at carbon 3 and stereochemical analysis of D-serine dehydrase reaction. (1976) (31)
- Cross-talk between the Histidine Protein Kinase VanS and the Response Regulator PhoB CHARACTERIZATION AND IDENTIFICATION OF A VanS DOMAIN THAT INHIBITS ACTIVATION OF PhoB* (1995) (31)
- Characterization of molecular interactions between ACP and halogenase domains in the Curacin A polyketide synthase. (2012) (31)
- Crystallographic Evidence of Drastic Conformational Changes in the Active Site of a Flavin-Dependent N-Hydroxylase (2014) (31)
- New ways to squash superbugs. (2009) (30)
- C-methyltransferase and cyclization domain activity at the intraprotein PK/NRP switch point of yersiniabactin synthetase. (2001) (30)
- Yersiniabactin synthetase: probing the recognition of carrier protein domains by the catalytic heterocyclization domains, Cy1 and Cy2, in the chain-initiating HWMP2 subunit. (2001) (30)
- Expression of bovine vitamin K-dependent carboxylase activity in baculovirus-infected insect cells. (1993) (30)
- The FAD Cofactor of RebC Shifts to an IN Conformation upon Flavin Reduction†,‡ (2008) (30)
- Mechanistic studies with vinylglycine and beta-haloaminobutyrates as substrates for cystathionine gamma-synthetase from Salmonella typhimurium. (1979) (30)
- Blurring the lines between ribosomal and nonribosomal peptide scaffolds. (2014) (30)
- Separation of flavins and flavin analogs by high-performance liquid chromatography. (1986) (29)
- Morphing peptide backbones into heterocycles (2008) (29)
- Prephenate decarboxylases: a new prephenate-utilizing enzyme family that performs nonaromatizing decarboxylation en route to diverse secondary metabolites. (2010) (29)
- Stereochemical outcome of processing of fluorinated substrates by ATP citrate lyase and malate synthase. (1981) (29)
- Kinetic comparison of the specificity of the vancomycin resistance VanSfor two response regulators, VanR and PhoB. (1996) (29)
- Evidence for a glutathionyl-enzyme intermediate in the amidase activity of the bifunctional glutathionylspermidine synthetase/amidase from Escherichia coli. (1997) (29)
- Mutational analysis of parasite trypanothione reductase: acquisition of glutathione reductase activity in a triple mutant. (1991) (29)
- Site-specific observation of acyl intermediate processing in thiotemplate biosynthesis by fourier transform mass spectrometry: the polyketide module of yersiniabactin synthetase. (2003) (29)
- Erratum: Assembly line enzymology by multimodular nonribosomal peptide synthetases: The thioesterase domain of E. coli EntF catalyzes both elongation and cyclolactonization (Chemistry and Biology (1999) 6 (385-400)) (1999) (29)
- Redox enzyme engineering: conversion of human glutathione reductase into a trypanothione reductase. (1991) (29)
- Design, synthesis, and biochemical evaluation of phosphonate and phosphonamidate analogs of glutathionylspermidine as inhibitors of glutathionylspermidine synthetase/amidase from Escherichia coli. (1997) (29)
- Molecular studies on trypanothione reductase, a target for antiparasitic drugs. (1991) (29)
- Stereochemistry of propionyl-coenzyme A and pyruvate carboxylations catalyzed by transcarboxylase. (1975) (28)
- The involvement of a 'bay-region' and a non-'bay-region' diol-epoxide in the metabolic activation of benz[a]anthracene in mouse skin and in hamster embryo cells. (1980) (28)
- Specific proteolysis of native alanine racemases from Salmonella typhimurium: identification of the cleavage site and characterization of the clipped two-domain proteins. (1987) (28)
- Dimeric structure of the six-domain VibF subunit of vibriobactin synthetase: mutant domain activity regain and ultracentrifugation studies. (2003) (28)
- Biosynthetic thiolase from Zoogloea ramigera. II. Inactivation with haloacetyl CoA analogs. (1987) (28)
- Fluorinated substrate analogues as stereochemical probes of enzymatic reaction mechanisms. (1978) (28)
- Coupling of alanine racemase and D-alanine dehydrogenase to active transport of amino acids in Escherichia coli B membrane vesicles. (1975) (28)
- Bio-Claisen condensation catalyzed by thiolase from Zoogloea ramigera. Active site cysteine residues (1989) (28)
- Kinetic characterization of the [3'-32P]coenzyme A/acetyl coenzyme A exchange catalyzed by a three-subunit form of the carbon monoxide dehydrogenase/acetyl-CoA synthase from Clostridium thermoaceticum. (1989) (28)
- Construction of a synthetic gene for the metalloregulatory protein MerR and analysis of regionally mutated proteins for transcriptional regulation. (1994) (27)
- Kinetic analysis of three activated phenylalanyl intermediates generated by the initiation module PheATE of gramicidin S synthetase. (2001) (27)
- Recent Advances in Enzymatic Complexity Generation: Cyclization Reactions. (2017) (27)
- The crystal structure of the novobiocin biosynthetic enzyme NovP: the first representative structure for the TylF O-methyltransferase superfamily. (2010) (27)
- Additional evidence for the involvement of the 3,4-diol 1,2-oxides in the metabolic activation of 7,12-dimethylbenz[a]anthracene in mouse skin. (1980) (27)
- Oxygen reactivity of p-hydroxybenzoate hydroxylase containing 1-deaza-FAD. (1980) (27)
- Price ER, Jin MJ, Lim D et al.Cyclophilin B trafficking through the secretory pathway is altered by binding of cyclosporin A. Proc Natl Acad Sci USA 91:3931-3935 (1994) (27)
- Dithiol Compounds: Potent, Time-Dependent Inhibitors of VanX, a Zinc-Dependent d,d-Dipeptidase Required for Vancomycin Resistance in Enterococcus faecium (1996) (27)
- Active-site mutants of the VanC2 D-alanyl-D-serine ligase, characteristic of one vancomycin-resistant bacterial phenotype, revert towards wild-type D-alanyl-D-alanine ligases. (1998) (27)
- Installation of the pyrrolyl-2-carboxyl pharmacophore by CouN1 and CouN7 in the late biosynthetic steps of the aminocoumarin antibiotics clorobiocin and coumermycin A1. (2006) (27)
- Chemoenzymatic formation of novel aminocoumarin antibiotics by the enzymes CouN1 and CouN7. (2007) (27)
- Carrier protein recognition in siderophore-producing nonribosomal peptide synthetases. (2002) (26)
- The mutant Escherichia coli F112W cyclophilin binds cyclosporin A in nearly identical conformation as human cyclophilin. (1994) (26)
- Characterization of the cereulide NRPS alpha-hydroxy acid specifying modules: activation of alpha-keto acids and chiral reduction on the assembly line. (2006) (26)
- Chorismate aminations: partial purification of Escherichia coli PABA synthase and mechanistic comparison with anthranilate synthase. (1987) (26)
- Acyl-CoA hydrolysis by the high molecular weight protein 1 subunit of yersiniabactin synthetase: mutational evidence for a cascade of four acyl-enzyme intermediates during hydrolytic editing. (2000) (26)
- Enzymatic Glycosylation of Vancomycin Aglycon: Completion of a Total Synthesis of Vancomycin and N- and C-Terminus Substituent Effects of the Aglycon Substrate (2014) (26)
- The Position of a Key Tyrosine in dTDP-4-Keto-6-deoxy-D-glucose-5-epimerase (EvaD) Alters the Substrate Profile for This RmlC-like Enzyme* (2004) (25)
- Nickel coordination in deazaflavin and viologen-reducing hydrogenases from Methanobacterium thermoautotrophicum: investigation by electron spin echo spectroscopy (1984) (25)
- p-Aminobenzoate synthesis in Escherichia coli: mutational analysis of three conserved amino acid residues of the amidotransferase PabA. (1993) (25)
- A double TROSY hNCAnH experiment for efficient assignment of large and challenging proteins. (2009) (25)
- The preparation of dihydrodiols from 7-methylbenz[a]-anthracene. (1978) (25)
- Mutagenesis of Vitamin K-dependent Carboxylase Demonstrates a Carboxyl Terminus-mediated Interaction with Vitamin K Hydroquinone (*) (1995) (25)
- Crystallization and preliminary crystallographic analysis of trypanothione reductase from Trypanosoma cruzi, the causative agent of Chagas' disease (1993) (25)
- Role of the active site cysteine of DpgA, a bacterial type III polyketide synthase. (2004) (25)
- Nickel-containing carbon monoxide dehydrogenase catalyzes reversible decarbonylation of acetyl CoA with retention of stereochemistry at the methyl group (1987) (24)
- Isolation and characterization of mutations in the HXK2 gene of Saccharomyces cerevisiae (1989) (24)
- Analysis of fluoromethyl group chirality establishes a common stereochemical course for the enolpyruvyl transfers catalyzed by EPSP synthase and UDP-GlcNAc enolpyruvyl transferase. (1996) (24)
- Mechanistic studies with deuterated dihydroorotates on the dihydroorotate oxidase from Crithidia fasciculata. (1984) (24)
- Preparation, characterization, and coenzymic properties of 5-carba-5-deaza and 1-carba-1-deaza analogs of riboflavin, FMN, and FAD. (1980) (24)
- In Vitro Reconstitution of Metabolic Pathways: Insights into Nature’s Chemical Logic (2015) (24)
- Excision of the epothilone synthetase B cyclization domain and demonstration of in trans condensation/cyclodehydration activity. (2005) (24)
- FenF: Servicing the Mycosubtilin Synthetase Assembly Line in trans (2007) (23)
- Enhanced macrocyclizing activity of the thioesterase from tyrocidine synthetase in presence of nonionic detergent. (2004) (23)
- Prospects for Antibacterial Discovery and Development. (2021) (23)
- Action and timing of BacC and BacD in the late stages of biosynthesis of the dipeptide antibiotic bacilysin. (2013) (23)
- Purification, crystallization, and preliminary x-ray diffraction studies of the flavoenzyme mercuric ion reductase from Bacillus sp. strain RC607. (1989) (23)
- Kinetic analysis of teicoplanin glycosyltransferases and acyltransferase reveal ordered tailoring of aglycone scaffold to reconstitute mature teicoplanin. (2007) (23)
- The McbB component of microcin B17 synthetase is a zinc metalloprotein. (2000) (23)
- Chirality of peptide bond-forming condensation domains in nonribosomal peptide synthetases: the C5 domain of tyrocidine synthetase is a (D)C(L) catalyst. (2003) (23)
- Chemical and enzymatic properties of riboflavin analogues. (1978) (23)
- Portability of oxidase domains in nonribosomal peptide synthetase modules. (2004) (22)
- Stereochemical studies on the hydration of monofluorofumarate and 2,3-difluorofumarate by fumarase. (1982) (22)
- Novel inhibitors of trypanothione biosynthesis: Synthesis and evaluation of a phosphinate analog of glutathionyl spermidine (GSP), a potent, slow-binding inhibitor of GSP synthetase (1997) (22)
- { alpha }-ketoglutarate-and O 2-dependent halogenase From The Cover : SyrB 2 in syringomycin E biosynthesis is a nonheme FeII (2005) (22)
- Characterization of the aminocoumarin ligase SimL from the simocyclinone pathway and tandem incubation with NovM,P,N from the novobiocin pathway. (2005) (22)
- Characterisation of Streptomyces spheroides NovW and revision of its functional assignment to a dTDP-6-deoxy-D-xylo-4-hexulose 3-epimerase. (2006) (22)
- Allylic and propargylic phenyl selenide oxygenation by cyclohexanone oxygenase: [2,3]-sigmatraopic rearrangement of the enzyme-generated selenoxide (1986) (22)
- Isolation and Structure Elucidation of the 4-Amino-4-deoxychorismate Intermediate in the PABA Enzymic Pathway (1991) (22)
- The loading and initial elongation modules of rifamycin synthetase collaborate to produce mixed aryl ketide products. (2002) (22)
- Regioselectivity and Chemoselectivity Analysis of Oxazole and Thiazole Ring Formation by the Peptide-Heterocyclizing Microcin B17 Synthetase Using High-Resolution MS/MS (1998) (21)
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- D-Ala-D-X ligases: evaluation of D-alanyl phosphate intermediate by MIX, PIX and rapid quench studies. (2000) (21)
- Bacterial organomercurial lyase: novel enzymic protonolysis of organostannanes (1988) (21)
- Determination of the absolute number of Escherichia coli membrane vesicles that catalyze active transport. (1974) (21)
- Olefin isomerization regiochemistries during tandem action of BacA and BacB on prephenate in bacilysin biosynthesis. (2012) (21)
- Resonance Raman and coherent anti-stokes Raman scattering spectra of flavin derivatives. Vibrational assignments and the zwitterionic structure of 8-methylamino-riboflavin. (1980) (21)
- Mass spectrometric characterization of a three-enzyme tandem reaction for assembly and modification of the novobiocin skeleton. (2004) (21)
- Polyketide-nonribosomal peptide epothilone antitumor agents: the EpoA, B, C subunits (2003) (20)
- X-ray crystallographic studies of the alanine-specific racemase from Bacillus stearothermophilus. Overproduction, crystallization, and preliminary characterization. (1987) (20)
- Dioxygen transfer during vitamin K dependent carboxylase catalysis. (1992) (20)
- CmaE: a transferase shuttling aminoacyl groups between carrier protein domains in the coronamic acid biosynthetic pathway. (2007) (20)
- Non‐Heme Hydroxylase Engineering For Simple Enzymatic Synthesis of L‐threo‐Hydroxyaspartic Acid (2008) (20)
- Studies on the kinetics and stoichiometry of inactivation of Pseudomonas omega-amino acid:pyruvate transaminase by gabaculine. (1980) (20)
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- Role of tyrosine residues in Hg(II) detoxification by mercuric reductase from Bacillus sp. strain RC607. (1993) (19)
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- Kinetic Characterization of the Inactivation of UDP-GlcNAc Enolpyruvyl Transferase by (Z)-3-Fluorophosphoenolpyruvate: Evidence for Two Oxocarbenium Ion Intermediates in Enolpyruvyl Transfer Catalysis (1995) (19)
- Purification and initial characterization of the lymphoid-cell protein-tyrosine kinase p56lck from a baculovirus expression system. (1991) (19)
- Directing Biosynthesis (2006) (19)
- Synthesis of proposed oxidation-cyclization-methylation intermediates of the coumarin antibiotic biosynthetic pathway. (2003) (19)
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- The 1.6‐Å resolution crystal structure of NovW: A 4‐keto‐6‐deoxy sugar epimerase from the novobiocin biosynthetic gene cluster of Streptomyces spheroides (2006) (18)
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- MICROCIN LEADER PEPTIDE FROM E. COLI, NMR, 25 STRUCTURES (1998) (0)
- Online capillary LC-FTMS for the analysis of covalent enzyme intermediates of polyketide and nonribosomal peptide synthetases (2002) (0)
- Vitamin B 2 : Riboflavin . Richard S. Rivlin, Ed. Plenum, New York, 1975. xiv, 434 pp., illus. $46.90. (1975) (0)
- Dowling, Daniel P. and Kung, Yan and Croft, Anna K. and Taghizadeh, Koli and Kelly, Wendy L. and Walsh, Christopher T. and Drennan, Catherine L. (2016) Structural elements of an NRPS cyclization (2017) (0)
- Correction to The ATP-Dependent Amide Ligases DdaG and DdaF Assemble the Fumaramoyl-Dipeptide Scaffold of the Dapdiamide Antibiotics (2010) (0)
- Native and K252c bound RebC-10x (2012) (0)
- HUMAN GLUTATHIONE REDUCTASE A34E/R37W MUTANT (1997) (0)
- Determination oftheAbsolute NumberofEscherwhia coliMembrane Vesicles ThatCatalyze Active Transport*t (1974) (0)
- Overexpression, purification, andcharacterization ofSHPTP1,a Srchomology 2-containing protein-tyrosine -phosphatase (1993) (0)
- Nature's Assembly Line Logic for Natural Products (2005) (0)
- NOVEL CHEMISTRY STILL TO BE FOUND IN NATURE (2014) (0)
- Mechanisms: The logic of biological process (2005) (0)
- A methanogen hydrogenase reduces a [3Fe3S] flavoprotein (1989) (0)
- Enzymology of Acyl Chain Macrocyclization in Natural Product Biosynthesis (2003) (0)
- Crystal structure of E. coli MccB + MccA-N7isoASN (2009) (0)
- mutagenesis and selection A protein interaction surface in nonribosomal peptide synthesis mapped by combinatorial (2006) (0)
- Introduction to Major Antibiotic Classes and Modes of Action (2003) (0)
- Enterobactin Hydolase IroE Complex with DFP (2006) (0)
- Propeptide and Glutamate Substrate Binding Sites on the Vitamin K-dependent Carboxylase Identified by Site-directed Mutagenesis (1996) (0)
- Crystal structure of E. coli MccB + AMPCPP + SeMeT MccA (2009) (0)
- How Nature Morphs Reptide Scaffolds into Antibiotics (2009) (0)
- Substrate analogues as mechanistic probes of methyl coenzyme m reductase from methanobacterium thermoautotrophicumdelta h (1986) (0)
- as Terminal Electron Acceptor : From TCA Cycle to Cytochrome Oxidase V 9 . 2 . Iron-Based Oxygenases (2017) (0)
- Catalytic mercury reduction by the detoxification enzyme, mercuric ion reductase, requires four active site cysteines located at the subunit interface (1989) (0)
- The three-dimensional structure of mercuric ion reductase from Bacillus sp. strain RC607 (1991) (0)
- Phosphopantethenyltransferasen and their uses (1996) (0)
- Mutagenesis of paired cysteine residues in the disulphide-containing flavoprotein mercuric ion reductase from mercury-resistant bacteria. (1988) (0)
- Biochemistry of naturally-occurring deazaflavin coenzymes (1984) (0)
- Determination of the Absolute Number of Escherwhia coli Membrane Vesicles That Catalyze Active Transport * t ( vinylglycolate / 2-hydroxy-3-butenoate / D-lactate / radioautography / electron microscopy ) (0)
- ON THE MECHANISM OF MERCURIC REDUCTASE: AN ALTERNATING SITES HYPOTHESIS (1991) (0)
- NMR structure of holo-ACPI domain from CurA module from Lyngbya majuscula (2011) (0)
- -glycosyltransferase C characterization of IroB, a pathogen-associated In vitro From The Cover: (2006) (0)
- DEEPTHI. T.V. “METAL CHELATES OF 1,3-DIKETONES STRUCTURALLY RELATED TO CURCUMINOIDS”. THESIS. DEPARTMENT OF CHEMISTRY,SREE NEELAKANTA (0)
- ENCYMATIC REDUCTION OF 5-DEAZARIBOFLAVINE FROM REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE BY DIRECT HYDROGEN TRANSFER (1974) (0)
- phosphopantetheinyl transferase Genetically encoded short peptide tag for versatile protein labeling by Sfp (2005) (0)
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