Christine S. Chow
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Chemist
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Chemistry
Christine S. Chow's Degrees
- PhD Chemistry University of California, Berkeley
- Bachelors Chemistry University of California, Berkeley
Why Is Christine S. Chow Influential?
(Suggest an Edit or Addition)According to Wikipedia, Christine "Christy" Chow is a professor of chemistry and former associate dean of the College of Liberal Arts and Sciences at Wayne State University. She works on modified RNAs, RNA-ligand interactions and RNA therapeutics. She is a Fellow of the American Chemical Society .
Christine S. Chow's Published Works
Published Works
- A Structural Basis for RNA−Ligand Interactions (1997) (184)
- High-mobility-group 1 protein mediates DNA bending as determined by ring closures. (1993) (183)
- Aminoglycosides modified by resistance enzymes display diminished binding to the bacterial ribosomal aminoacyl-tRNA site. (2002) (144)
- Expanding the nucleotide repertoire of the ribosome with post-transcriptional modifications. (2007) (139)
- Design of novel antibiotics that bind to the ribosomal acyltransfer site. (2002) (136)
- Transition metal complexes as probes of nucleic acids. (1992) (107)
- Production of Nanostructures of DNA on Surfaces (2002) (98)
- Unique structural and stabilizing roles for the individual pseudouridine residues in the 1920 region of Escherichia coli 23S rRNA. (2000) (89)
- HMG domain proteins induce sharp bends in cisplatin-modified DNA. (1994) (76)
- Structural and Kinetic Studies of a Cisplatin-modified DNA Icosamer Binding to HMG1 Domain B* (1999) (72)
- A single HMG domain in high-mobility group 1 protein binds to DNAs as small as 20 base pairs containing the major cisplatin adduct. (1995) (56)
- A Structural Basis for RNA-Ligand Interactions (1997) (54)
- Effects of nucleotide substitution and modification on the stability and structure of helix 69 from 28S rRNA. (2005) (53)
- Recognition of tertiary structure in tRNAs by Rh(phen)2phi3+, a new reagent for RNA structure-function mapping. (1992) (49)
- Shape-selective cleavage of tRNAPhe by transition metal complexes (1990) (47)
- Characterization of a novel alpha1,2-fucosyltransferase of Escherichia coli O128:b12 and functional investigation of its common motif. (2008) (42)
- A modified fluorescent intercalator displacement assay for RNA ligand discovery. (2011) (42)
- Pseudouridines in rRNA helix 69 play a role in loop stacking interactions. (2008) (41)
- Recognition of G-U mismatches by tris(4,7-diphenyl-1,10-phenanthroline)rhodium(III). (1992) (40)
- Design, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens. (2019) (38)
- Identification of a new alpha1,2-fucosyltransferase involved in O-antigen biosynthesis of Escherichia coli O86:B7 and formation of H-type 3 blood group antigen. (2008) (38)
- RNA-aminoglycoside antibiotic interactions: fluorescence detection of binding and conformational change. (1999) (35)
- Histone stoichiometry and DNA circularization in archaeal nucleosomes. (1999) (34)
- Synthesis of helix 69 of Escherichia coli 23S rRNA containing its natural modified nucleosides, m3ψ and ψ (2002) (33)
- Thermodynamics of RNA hairpins containing single internal mismatches. (1999) (32)
- Selection of peptides that target the aminoacyl-tRNA site of bacterial 16S ribosomal RNA. (2009) (30)
- Post-transcriptional Modifications Modulate rRNA Structure and Ligand Interactions. (2016) (30)
- A new role for cisplatin: probing ribosomal RNA structure. (2009) (29)
- Evaluation of Hybrid Theoretical Approaches for Structural Determination of a Glycine-Linked Cisplatin Derivative via Infrared Multiple Photon Dissociation (IRMPD) Action Spectroscopy. (2015) (29)
- More pronounced salt dependence and higher reactivity for platination of the hairpin r(CGCGUUGUUCGCG) compared with d(CGCGTTGTTCGCG) (2006) (29)
- Delineation of structural domains in eukaryotic 5S rRNA with a rhodium probe. (1992) (27)
- pH-dependent structural changes of helix 69 from Escherichia coli 23S ribosomal RNA. (2008) (27)
- Identification and role of functionally important motifs in the 970 loop of Escherichia coli 16S ribosomal RNA. (2008) (26)
- Synthesis and solution conformation studies of 3-substituted uridine and pseudouridine derivatives. (2008) (25)
- Probing conformational states of modified helix 69 in 50S ribosomes. (2011) (25)
- Single-molecule FRET reveals a cooperative effect of two methyl group modifications in the folding of human mitochondrial tRNA(Lys). (2011) (23)
- Role of pseudouridine in structural rearrangements of helix 69 during bacterial ribosome assembly. (2012) (23)
- Combined Approaches to Site-Specific Modification of RNA. (2008) (22)
- Structure modulation of helix 69 from Escherichia coli 23S ribosomal RNA by pseudouridylations (2013) (22)
- Amino acid-linked platinum(II) analogues have altered specificity for RNA compared to cisplatin. (2014) (22)
- Selection of Peptides Targeting Helix 31 of Bacterial 16S Ribosomal RNA by Screening M13 Phage-Display Libraries (2011) (22)
- Ligand- and pH-induced conformational changes of RNA domain helix 69 revealed by 2-aminopurine fluorescence. (2012) (21)
- Monitoring aminoglycoside-induced conformational changes in 16S rRNA through acrylamide quenching. (2007) (21)
- Comparison of solution conformations and stabilities of modified helix 69 rRNA analogs from bacteria and human. (2012) (19)
- Synthesis of a 3-methyluridine phosphoramidite to investigate the role of methylation in a ribosomal RNA hairpin. (2002) (17)
- A practical synthesis of the modified RNA nucleoside pseudouridine (1999) (15)
- Automated reticulocyte counting--an evaluation of GEN-S, Cell-Dyn 3500 and Cell-Dyn 4000. (1999) (14)
- Modified Nucleosides in Biochemistry, Biotechnology and Medicine (2009) (13)
- Cisplatin Targeting of Bacterial Ribosomal RNA Hairpins (2015) (13)
- A Structural Basis for RNAminus signLigand Interactions. (1997) (13)
- Reactions of platinum(II) complexes with a DNA hairpin, d(CGCGTTGTTCGCG): structural characterization and kinetic studies (2000) (12)
- The synthesis of allyl- and allyloxycarbonyl-protected RNA phosphoramidites. Useful reagents for solid-phase synthesis of RNAs with base-labile modifications (1998) (12)
- Chemical probing for examining the structure of modified RNAs and ligand binding to RNA. (2019) (12)
- Synthesis and solution conformation studies of the modified nucleoside N(4),2'-O-dimethylcytidine (m(4)Cm) and its analogues. (2008) (12)
- Redox-Inactive Peptide Disrupting Trx1-Ask1 Interaction for Selective Activation of Stress Signaling. (2018) (12)
- Selection of heptapeptides that bind helix 69 of bacterial 23S ribosomal RNA. (2013) (11)
- Solution conformations of two naturally occurring RNA nucleosides: 3-methyluridine and 3-methylpseudouridine. (2005) (11)
- NMR conformational analysis of p-tolyl furanopyrimidine 2'-deoxyribonucleoside and crystal structure of its 3',5'-di-O-acetyl derivative. (2005) (10)
- Probing RNA hairpins with cobalt(III)hexammine and electrospray ionization mass spectrometry (2006) (10)
- An Advanced Apralog with Increased in vitro and in vivo Activity toward Gram‐negative Pathogens and Reduced ex vivo Cochleotoxicity (2020) (9)
- Structural and Kinetic Studies of a Cisplatin-modified DNA Icosamer Binding to HMG 1 Domain B (1999) (8)
- Synthesis and characterization of modified nucleotides in the 970 hairpin loop of Escherichia coli 16S ribosomal RNA. (2009) (8)
- Expression and in vivo characterization of the antimicrobial peptide oncocin and variants binding to ribosomes. (2020) (8)
- Helix 69: A Multitasking RNA Motif as a Novel Drug Target (2013) (7)
- Synthesis of helix 69 of Escherichia coli 23S rRNA containing its natural modified nucleosides, m(3)Psi and Psi. (2002) (7)
- Calculations of pKa Values for a Series of Naturally Occurring Modified Nucleobases. (2022) (6)
- Synthesis and Purification of a Hammerhead Ribozyme and a Fluorescein-Labeled RNA Substrate. A Biochemistry Laboratory: Part 1 (1999) (6)
- The development of peptide ligands that target helix 69 rRNA of bacterial ribosomes. (2016) (6)
- Modulation of conformational changes in helix 69 mutants by pseudouridine modifications. (2015) (6)
- Modified Nucleosides in RNA (2008) (6)
- Probing the stabilizing effects of modified nucleotides in the bacterial decoding region of 16S ribosomal RNA. (2013) (5)
- Photoinduced cleavage by a rhodium complex at G.U mismatches and exposed guanines in large and small RNAs. (2002) (5)
- Monitoring Hammerhead Ribozyme-Catalyzed Cleavage with a Fluorescein-Labeled Substrate: Effects of Magnesium Ions and Antibiotic Inhibitors. A Biochemistry Laboratory: Part 2 (1999) (4)
- Synthesis of 15N-enriched pseudouridine derivatives. (2003) (4)
- Amino acid-linked platinum(II) compounds: non-canonical nucleoside preferences and influence on glycosidic bond stabilities (2019) (3)
- Structural determination of arginine-linked cisplatin complexes via IRMPD action spectroscopy: arginine binds to platinum via NO- binding mode. (2021) (3)
- Pseudouridine modifications influence binding of aminoglycosides to helix 69 of bacterial ribosomes. (2017) (2)
- Use of a fluorescence assay to determine relative affinities of semisynthetic aminoglycosides to small RNAs representing bacterial and mitochondrial A sites. (2019) (2)
- Binding of Antibiotics to the Aminoacyl-Trna Site of Bacterial Ribosome (2007) (2)
- The use of electrospray ionization mass spectrometry to monitor RNA-ligand interactions. (2019) (2)
- Site-selective cleavage of tRNA and 5S rRNA by Rh(phen)2(phi)3+ and Rh(DIP)33+ (1991) (0)
- High-mobility-group 1 protein mediates DNA bending as determined by ring closures ( bending / DNA circles ) (2005) (0)
- Unmodified Helix 69 (2014) (0)
- The Synthesis of Allyl- and Allyloxycarbonyl-Protected RNA Phosphoramidites. Useful Reagents for Solid-Phase Synthesis of RNAs with Base-Labile Modifications. (1998) (0)
- Crystal structure of the Thermus thermophilus 70S ribosome in complex with propylamycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.75A resolution (2019) (0)
- In vivo expression of H69-targeting peptides in bacteria (2016) (0)
- New Ionization Processes for Ionizing Nonvolatile Compounds in Mass Spectrometry: The Road of Discovery to Current State-of-the-Art (2020) (0)
- Site-specifically modified ribosomal RNAs (2008) (0)
- Recognition of cisplatin-modified DNA by proteins with HMG-box domains (1993) (0)
- The use of peptide as novel antibiotic development against the bacterial ribosome (2008) (0)
- FOCUS :N UCLEIC ACIDS IN MASS SPECTROMETRY Probing RNA Hairpins with Cobalt(III)hexammine and Electrospray Ionization Mass Spectrometry (2006) (0)
- Carbohydrate‐linked cisplatin analogue: reactivity studies with RNA and DNA (2017) (0)
- Transition metal complexes as probes for higher-order structure in RNA (1992) (0)
- Calculated pKa Values for a Series of Aza- and Deaza-Modified Nucleobases (2023) (0)
- FOCUS: NUCLEIC ACIDS IN MASS SPECTROMETRY Probing RNA Hairpins with Cobalt(III)hexammine and Electrospray Ionization Mass Spectrometry (2006) (0)
- Site-selective cleavage of tRNAPhe by metal complexes (1989) (0)
- Synthesis of Helix 69 of Escherichia coli 23S rRNA Containing Its Natural Modified Nucleosides, m3Ψ and Ψ. (2003) (0)
- Structure Determination of Ornithine-Linked Cisplatin by Infrared Multiple Photon Dissociation Action Spectroscopy (2016) (0)
- Determination of Structural Interaction Between T Box Antiterminator-tRNA Complex : Chemo-enzymatic probing (2004) (0)
- Structure of Helix 69 from Escherichia coli 23S Ribosomal RNA (2014) (0)
- STRUCTURE DETERMINATION OF CISPLATIN-AMINO ACID ANALOGUES BY INFRARED MULTIPLE PHOTON DISSOCIATION ACTION SPECTROSCOPY (2015) (0)
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