Chuan He
#32,793
Most Influential Person Now
Chinese-American chemical biologist
Chuan He's AcademicInfluence.com Rankings
Chuan Hechemistry Degrees
Chemistry
#889
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#1452
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Organic Chemistry
#197
World Rank
#249
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Chemistry
Chuan He's Degrees
- PhD Chemistry University of California, Berkeley
- Bachelors Chemistry Peking University
Why Is Chuan He Influential?
(Suggest an Edit or Addition)According to Wikipedia, Chuan He is a Chinese-American chemical biologist. He currently serves as the John T. Wilson Distinguished Service Professor at the University of Chicago, and an Investigator of the Howard Hughes Medical Institute. He is best known for his work in discovering and deciphering reversible RNA methylation in post-transcriptional gene expression regulation. He was awarded the 2023 Wolf Prize in Chemistry for his work in discovering and deciphering reversible RNA methylation in post-transcriptional gene expression regulation in addition to his contributions to the invention of TAB-seq, a biochemical method that can map 5-hydroxymethylcytosine at base-resolution genome-wide, as well as hmC-Seal, a method that covalently labels 5hmC for its detection and profiling.
Chuan He's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine (2011) (2895)
- N6-Methyladenosine in Nuclear RNA is a Major Substrate of the Obesity-Associated FTO (2011) (2512)
- ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. (2013) (2105)
- m6A-dependent regulation of messenger RNA stability (2013) (2037)
- N 6 -methyladenosine Modulates Messenger RNA Translation Efficiency (2015) (1978)
- A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation (2013) (1902)
- Dynamic RNA Modifications in Gene Expression Regulation (2017) (1647)
- Global Epigenomic Reconfiguration During Mammalian Brain Development (2013) (1562)
- Post-transcriptional gene regulation by mRNA modifications (2016) (1239)
- Recognition of RNA N6-methyladenosine by IGF2BP Proteins Enhances mRNA Stability and Translation (2018) (1174)
- N6-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions (2015) (1014)
- YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA (2017) (984)
- m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program. (2017) (953)
- FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N6-Methyladenosine RNA Demethylase. (2017) (929)
- Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers. (2019) (771)
- FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis (2014) (771)
- m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells (2017) (755)
- RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation (2015) (630)
- The dynamic N1-methyladenosine methylome in eukaryotic messenger RNA (2016) (630)
- R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling (2018) (624)
- METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification. (2017) (612)
- YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs (2017) (590)
- Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis (2017) (550)
- Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing. (2016) (548)
- RNA modifications modulate gene expression during development (2018) (547)
- DNA Methylation on N6-Adenine in C. elegans (2015) (491)
- Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation (2017) (490)
- VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation (2018) (488)
- Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal. (2018) (476)
- N6-Methyladenine DNA Modification in Drosophila (2015) (473)
- m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer (2018) (464)
- m6A RNA methylation regulates the UV-induced DNA damage response (2017) (440)
- Anti-tumor immunity controlled through mRNA m6A and YTHDF1 in dendritic cells (2019) (423)
- Sperm, but Not Oocyte, DNA Methylome Is Inherited by Zebrafish Early Embryos (2013) (389)
- N 6-Methyldeoxyadenosine Marks Active Transcription Start Sites in Chlamydomonas (2015) (373)
- m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition (2016) (366)
- Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm. (2018) (363)
- N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis (2017) (356)
- Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally (2019) (340)
- Grand challenge commentary: RNA epigenetics? (2010) (339)
- Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. (2012) (336)
- RNA m6A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail (2019) (327)
- ALKBH1-Mediated tRNA Demethylation Regulates Translation (2016) (326)
- Programming and Inheritance of Parental DNA Methylomes in Mammals (2014) (323)
- m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade (2019) (317)
- FTO-Mediated Formation of N6-Hydroxymethyladenosine and N6-Formyladenosine in Mammalian RNA (2013) (309)
- Fate by RNA methylation: m6A steers stem cell pluripotency (2015) (307)
- Unique Features of the m6A Methylome in Arabidopsis thaliana (2014) (306)
- N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription (2020) (299)
- m6A facilitates hippocampus-dependent learning and memory through Ythdf1 (2018) (284)
- Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA (2012) (283)
- 5mC oxidation by Tet2 modulates enhancer activity and timing of transcriptome reprogramming during differentiation. (2014) (279)
- Integrating 5-Hydroxymethylcytosine into the Epigenomic Landscape of Human Embryonic Stem Cells (2011) (276)
- High-resolution N(6) -methyladenosine (m(6) A) map using photo-crosslinking-assisted m(6) A sequencing. (2015) (268)
- Dynamics of Human and Viral RNA Methylation during Zika Virus Infection. (2016) (267)
- Epigenetic mechanisms in neurogenesis (2016) (256)
- Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain (2014) (256)
- Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis (2017) (246)
- HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis (2013) (241)
- A METTL 3-METTL 14 complex mediates mammalian nuclear RNA N 6-adenosine methylation (2016) (234)
- DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia. (2014) (231)
- Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine (2014) (231)
- A protein engineered to bind uranyl selectively and with femtomolar affinity. (2014) (220)
- N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation (2018) (203)
- Transcriptome-wide Mapping of Internal N7-Methylguanosine Methylome in Mammalian mRNA. (2019) (203)
- 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers (2017) (200)
- N6-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression (2016) (197)
- 6-phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumor growth by inhibiting LKB1-AMPK signaling (2014) (189)
- Single-base mapping of m6A by an antibody-independent method (2019) (188)
- DNA N6-methyladenine: a new epigenetic mark in eukaryotes? (2015) (186)
- Nm-seq maps 2′-O-methylation sites in human mRNA with base precision (2017) (185)
- Bacterial infection remodels the DNA methylation landscape of human dendritic cells (2015) (184)
- Live Cell MicroRNA Imaging Using Cascade Hybridization Reaction. (2015) (181)
- Ythdf2-mediated m6A mRNA clearance modulates neural development in mice (2018) (180)
- Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig (2016) (179)
- Nucleic Acid Modifications in Regulation of Gene Expression. (2016) (179)
- Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG. (2019) (172)
- m6A RNA methylation: from mechanisms to therapeutic potential (2021) (171)
- 5-Formyl- and 5-carboxyl-cytosine reduce the rate and substrate specificity of RNA polymerase II transcription (2012) (171)
- YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma (2019) (164)
- Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation. (2018) (158)
- Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation. (2015) (156)
- Effects of cytosine modifications on DNA flexibility and nucleosome mechanical stability (2016) (155)
- RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia. (2020) (155)
- m 6 A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade (2019) (154)
- ALKBH10B Is an RNA N6-Methyladenosine Demethylase Affecting Arabidopsis Floral Transition[OPEN] (2017) (154)
- Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion (2018) (152)
- The emerging biology of RNA post-transcriptional modifications (2017) (152)
- YTHDF3 Induces the Translation of m6A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis. (2020) (145)
- Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells (2016) (143)
- FMRP Modulates Neural Differentiation through m6A-Dependent mRNA Nuclear Export (2019) (141)
- Molecular Basis for 5-Carboxycytosine Recognition by RNA Polymerase II Elongation Complex (2015) (140)
- Widespread occurrence of N6-methyladenosine in bacterial mRNA (2015) (140)
- TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells (2017) (134)
- Genome-wide mapping of 5-hydroxymethylcytosines in circulating cell-free DNA as a non-invasive approach for early detection of hepatocellular carcinoma (2019) (130)
- The multiple antibiotic resistance regulator MarR is a copper sensor in Escherichia coli. (2014) (128)
- Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer (2015) (127)
- N6-methyladenosine modification and the YTHDF2 reader protein play cell type specific roles in lytic viral gene expression during Kaposi's sarcoma-associated herpesvirus infection (2017) (124)
- TET1 regulates hypoxia-induced epithelial-mesenchymal transition by acting as a co-activator (2014) (123)
- N6-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I (2019) (122)
- Iron-Catalyzed Oxidation Intermediates Captured in a DNA Repair Dioxygenase (2010) (120)
- Dynamic RNA Modifications in Posttranscriptional Regulation (2014) (117)
- miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia (2016) (116)
- An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease (2020) (115)
- Enhanced 5-methylcytosine detection in single-molecule, real-time sequencing via Tet1 oxidation (2013) (115)
- Chemical Modifications in the Life of an mRNA Transcript. (2018) (114)
- RNA epigenetics--chemical messages for posttranscriptional gene regulation. (2016) (113)
- Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells (2016) (113)
- Decoding the epitranscriptional landscape from native RNA sequences (2018) (113)
- Programming and Inheritance of Parental DNA Methylomes in Mammals (2014) (112)
- Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling. (2015) (112)
- RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia (2018) (111)
- N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA. (2020) (110)
- Golden Pigment Production and Virulence Gene Expression Are Affected by Metabolisms in Staphylococcus aureus (2010) (105)
- Mapping new nucleotide variants in the genome and transcriptome (2012) (105)
- Bisulfite-free and Base-resolution Analysis of 5-formylcytosine at Whole-genome Scale (2015) (104)
- Regulation of Gene Expression by N6-methyladenosine in Cancer. (2019) (104)
- Upregulation of METTL14 mediates the elevation of PERP mRNA N6 adenosine methylation promoting the growth and metastasis of pancreatic cancer (2020) (100)
- EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma (2021) (99)
- In the Staphylococcus aureus Two-Component System sae, the Response Regulator SaeR Binds to a Direct Repeat Sequence and DNA Binding Requires Phosphorylation by the Sensor Kinase SaeS (2010) (99)
- A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations. (2016) (99)
- N6-methyldeoxyadenine is a transgenerational epigenetic signal for mitochondrial stress adaptation (2018) (97)
- A dynamic N6-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors (2018) (96)
- m6A mRNA Methylation Regulates Human β-Cell Biology in Physiological States and in Type 2 Diabetes (2019) (96)
- MeCP2 recognizes cytosine methylated tri-nucleotide and di-nucleotide sequences to tune transcription in the mammalian brain (2017) (96)
- A metabolic labeling method detects m6A transcriptome-wide at single base resolution (2020) (95)
- Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth. (2014) (95)
- Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis. (2014) (93)
- Reading RNA methylation codes through methyl-specific binding proteins (2014) (92)
- Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency (2013) (88)
- Sources of artifact in measurements of 6mA and 4mC abundance in eukaryotic genomic DNA (2019) (86)
- Crystal Structures of the Reduced, Sulfenic Acid, and Mixed Disulfide Forms of SarZ, a Redox Active Global Regulator in Staphylococcus aureus* (2009) (85)
- Epitranscriptomic influences on development and disease (2017) (85)
- Expression of Multidrug Resistance Efflux Pump Gene norA Is Iron Responsive in Staphylococcus aureus (2012) (81)
- Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation (2013) (80)
- Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis (2017) (80)
- Synthesis of a FTO inhibitor with anticonvulsant activity. (2014) (79)
- Crystal Structures of SlyA Protein, a Master Virulence Regulator of Salmonella, in Free and DNA-bound States* (2011) (78)
- Genetic Analyses Support the Contribution of mRNA N6-methyladenosine (m6A) Modification to Human Disease Heritability (2020) (77)
- Characterization of eukaryotic DNA N6-methyladenine by a highly sensitive restriction enzyme-assisted sequencing (2016) (77)
- Intramolecular amide bonds stabilize pili on the surface of bacilli (2009) (76)
- TET family proteins: oxidation activity, interacting molecules, and functions in diseases. (2015) (76)
- Kinetic gating mechanism of DNA damage recognition by Rad4/XPC (2015) (75)
- 2′-O-methylation in mRNA disrupts tRNA decoding during translation elongation (2018) (73)
- N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer’s disease (2021) (72)
- Spatiotemporal clustering of the epigenome reveals rules of dynamic gene regulation (2013) (70)
- N6-Methyladenosine–binding proteins suppress HIV-1 infectivity and viral production (2018) (70)
- The dynamics of DNA methylation fidelity during mouse embryonic stem cell self-renewal and differentiation (2014) (69)
- CcpA Mediates Proline Auxotrophy and Is Required for Staphylococcus aureus Pathogenesis (2010) (69)
- METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis (2022) (69)
- DNA N6-methyladenine in metazoans: functional epigenetic mark or bystander? (2017) (66)
- Base-resolution maps of 5-formylcytosine and 5-carboxylcytosine reveal genome-wide DNA demethylation dynamics (2015) (66)
- Mapping and characterizing N6-methyladenine in eukaryotic genomes using single-molecule real-time sequencing (2018) (65)
- Capsule anchoring in Bacillus anthracis occurs by a transpeptidation reaction that is inhibited by capsidin (2009) (61)
- Developing drugs targeting transition metal homeostasis. (2017) (60)
- RNA demethylation increases the yield and biomass of rice and potato plants in field trials (2021) (59)
- Iron homeostasis regulates the activity of the microRNA pathway through poly(C)-binding protein 2. (2012) (58)
- RNA m6A Modification in Cancers: Molecular Mechanisms and Potential Clinical Applications (2020) (58)
- Base-Resolution Analysis of Cisplatin-DNA Adducts at the Genome Scale. (2016) (57)
- The RNA-binding protein FMRP facilitates the nuclear export of N6-methyladenosine–containing mRNAs (2019) (57)
- 5-Hydroxymethylation-associated epigenetic modifiers of Alzheimer's disease modulate Tau-induced neurotoxicity. (2016) (56)
- Duplex Interrogation by a Direct DNA Repair Protein in Search of Base Damage (2012) (55)
- Evolution of a Reverse Transcriptase to Map N1-Methyladenosine in Human mRNA (2019) (54)
- Base-resolution detection of N4-methylcytosine in genomic DNA using 4mC-Tet-assisted-bisulfite- sequencing (2015) (54)
- Correction: N6-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression (2017) (53)
- m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome (2022) (51)
- Pseudouridine in a new era of RNA modifications (2014) (51)
- Weakened N3 Hydrogen Bonding by 5-Formylcytosine and 5-Carboxylcytosine Reduces Their Base-Pairing Stability. (2016) (50)
- RNA–protein interaction mapping via MS2- or Cas13-based APEX targeting (2020) (50)
- A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation (2020) (49)
- Publisher Correction: N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation (2019) (48)
- Circulating tumor DNA 5-hydroxymethylcytosine as a novel diagnostic biomarker for esophageal cancer (2018) (48)
- ALKBHs-facilitated RNA modifications and de-modifications. (2016) (48)
- Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis (2021) (48)
- Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m6A Methylation. (2020) (48)
- Bisulfite-Free, Nanoscale Analysis of 5-Hydroxymethylcytosine at Single Base Resolution. (2018) (48)
- Keth-seq for transcriptome-wide RNA structure mapping (2019) (47)
- FOXA1 potentiates lineage-specific enhancer activation through modulating TET1 expression and function (2016) (46)
- Evolution of transcript modification by N6-methyladenosine in primates. (2017) (46)
- ALKBH1-Mediated tRNA Demethylation Regulates Translation (2016) (46)
- N6-Allyladenosine: A New Small Molecule for RNA Labeling Identified by Mutation Assay. (2017) (46)
- Control of Early B Cell Development by the RNA N6-Methyladenosine Methylation. (2020) (46)
- REPIC: a database for exploring the N6-methyladenosine methylome (2019) (45)
- RADAR: differential analysis of MeRIP-seq data with a random effect model (2019) (45)
- Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia (2017) (45)
- A Critical Role of Nuclear m6A Reader YTHDC1 in Leukemogenesis by Regulating MCM Complex-Mediated DNA Replication. (2021) (42)
- Crystal structure of the RNA demethylase ALKBH5 from zebrafish (2014) (42)
- Post-translational modification of RNA m6A demethylase ALKBH5 regulates ROS-induced DNA damage response (2021) (42)
- METTL3-dependent RNA m6A dysregulation contributes to neurodegeneration in Alzheimer’s disease through aberrant cell cycle events (2021) (41)
- N6-methyldeoxyadenosine directs nucleosome positioning in Tetrahymena DNA (2018) (41)
- The Pseudomonas aeruginosa Global Regulator VqsR Directly Inhibits QscR To Control Quorum-Sensing and Virulence Gene Expression (2012) (41)
- Viral N6-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus (2019) (41)
- TET-mediated epimutagenesis of the Arabidopsis thaliana methylome (2017) (40)
- QSER1 protects DNA methylation valleys from de novo methylation (2021) (40)
- Our views of dynamic N6-methyladenosine RNA methylation (2018) (40)
- Pseudomonas aeruginosa Outer Membrane Vesicles Modulate Host Immune Responses by Targeting the Toll-Like Receptor 4 Signaling Pathway (2013) (40)
- Inhibition of Copper Transport Induces Apoptosis in Triple-Negative Breast Cancer Cells and Suppresses Tumor Angiogenesis (2019) (39)
- DNA Methylation on N 6-Adenine in C . elegans Graphical Abstract Highlights (2015) (39)
- Detailed modeling of positive selection improves detection of cancer driver genes (2019) (38)
- METTL14 facilitates global genome repair and suppresses skin tumorigenesis (2021) (38)
- Balance of DNA methylation and demethylation in cancer development (2012) (37)
- Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis. (2019) (37)
- Kethoxal-assisted single-stranded DNA sequencing captures global transcription dynamics and enhancer activity in situ (2020) (35)
- N6-Adenosine Methylation of Socs1 mRNA Is Required to Sustain the Negative Feedback Control of Macrophage Activation. (2020) (35)
- Application of a low cost array-based technique - TAB-Array - for quantifying and mapping both 5mC and 5hmC at single base resolution in human pluripotent stem cells. (2014) (35)
- FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development (2022) (35)
- Corrigendum: N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO (2012) (34)
- Quantifying mammalian genomic DNA hydroxymethylcytosine content using solid-state nanopores (2016) (33)
- Steady-State Hydrogen Peroxide Induces Glycolysis in Staphylococcus aureus and Pseudomonas aeruginosa (2014) (33)
- Modeling non-heme iron proteins. (2004) (33)
- Epigenetic DNA Modification N6-Methyladenine Causes Site-Specific RNA Polymerase II Transcriptional Pausing. (2017) (33)
- Molecular mechanisms of two-component system RhpRS regulating type III secretion system in Pseudomonas syringae (2014) (32)
- YTHDF2 promotes mitotic entry and is regulated by cell cycle mediators (2020) (32)
- Long genes linked to autism spectrum disorders harbor broad enhancer-like chromatin domains (2018) (30)
- RNA-protein interaction mapping via MS2 or Cas13-based APEX targeting (2020) (30)
- Chromatin and transcriptional regulation by reversible RNA methylation. (2021) (30)
- Progress toward liquid biopsies in pediatric solid tumors (2019) (29)
- Understanding Variation in Transcription Factor Binding by Modeling Transcription Factor Genome-Epigenome Interactions (2013) (29)
- Targeting PUS7 suppresses tRNA pseudouridylation and glioblastoma tumorigenesis (2021) (29)
- Transcriptome-wide reprogramming of N6-methyladenosine modification by the mouse microbiome (2018) (26)
- Prognostic implications of 5-hydroxymethylcytosines from circulating cell-free DNA in diffuse large B-cell lymphoma. (2019) (25)
- Author Correction: Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation (2018) (25)
- Direct DNA crosslinking with CAP-C uncovers transcription-dependent chromatin organization at high resolution (2020) (25)
- Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus (2016) (24)
- 5-Hydroxymethylcytosine-mediated alteration of transposon activity associated with the exposure to adverse in utero environments in human. (2016) (24)
- High-Resolution Mapping of N⁶-Methyladenosine in Transcriptome and Genome Using a Photo-Crosslinking-Assisted Strategy. (2015) (23)
- Publisher Correction: Post-transcriptional gene regulation by mRNA modifications (2018) (23)
- N6-methyladenosine modification of HIV-1 RNA suppresses type-I interferon induction in differentiated monocytic cells and primary macrophages (2021) (22)
- Corrigendum: RNA m6A methylation regulates the ultraviolet-induced DNA damage response (2017) (22)
- 6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda (2019) (22)
- Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation (2018) (22)
- Identification of MLL-fusion/MYC⊣miR-26⊣TET1 signaling circuit in MLL-rearranged leukemia. (2016) (21)
- ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing (2021) (20)
- "Gamete On" for m6A: YTHDF2 Exerts Essential Functions in Female Fertility. (2017) (20)
- Tet-Assisted Bisulfite Sequencing (TAB-seq). (2018) (20)
- Remodeling of the m6A landscape in the heart reveals few conserved post-transcriptional events underlying cardiomyocyte hypertrophy. (2020) (20)
- 5-Hydroxymethylcytosine Profiles in Circulating Cell-Free DNA Associate with Disease Burden in Children with Neuroblastoma (2019) (19)
- Pentafluorosulfanyl-Substituted Benzopyran Analogues As New Cyclooxygenase-2 Inhibitors with Excellent Pharmacokinetics and Efficacy in Blocking Inflammation. (2017) (19)
- Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells (2020) (17)
- Challenges and recommendations for epigenomics in precision health (2017) (17)
- N6‐methyladenosine modification of lncRNA Pvt1 governs epidermal stemness (2021) (16)
- Author Correction: Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells (2019) (16)
- Detection of mismatched 5-hydroxymethyluracil in DNA by selective chemical labeling. (2015) (15)
- Nonsegmented Negative-Sense RNA Viruses Utilize N6-Methyladenosine (m6A) as a Common Strategy To Evade Host Innate Immunity (2021) (15)
- 5-Hydroxymethylcytosines in Circulating Cell-Free DNA Reveal Vascular Complications of Type 2 Diabetes. (2019) (15)
- Jump-seq: Genome-Wide Capture and Amplification of 5-Hydroxymethylcytosine Sites. (2019) (15)
- Single base resolution mapping of 2'-O-methylation sites in human mRNA and in 3' terminal ends of small RNAs. (2019) (15)
- 5-Hydroxymethylcytosine Profiles Are Prognostic of Outcome in Neuroblastoma and Reveal Transcriptional Networks That Correlate With Tumor Phenotype (2019) (14)
- Cancer: Damage prevention targeted (2014) (14)
- Novel evidence for m6A methylation regulators as prognostic biomarkers and FTO as a potential therapeutic target in gastric cancer (2021) (14)
- N6-methyladenosine promotes induction of ADAR1-mediated A-to-I RNA editing to suppress aberrant antiviral innate immune responses (2021) (14)
- Thymine DNA glycosylase recognizes the geometry alteration of minor grooves induced by 5-formylcytosine and 5-carboxylcytosine† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc02807b (2019) (14)
- Site-specific m6A editing (2019) (13)
- LEAD-m6A-seq for Locus-specific Detection of N6-methyladenosine and Quantification of Differential Methylation. (2020) (12)
- Introduction: epigenetics. (2015) (11)
- m6A deposition is regulated by PRMT1‐mediated arginine methylation of METTL14 in its disordered C‐terminal region (2021) (11)
- METTL3 Regulates Liver Homeostasis, Hepatocyte Ploidy, and Circadian Rhythm-Controlled Gene Expression in Mice. (2021) (11)
- A new modification for mammalian messenger RNA (2017) (11)
- HRD1-mediated METTL14 degradation regulates m6A mRNA modification to suppress ER proteotoxic liver disease (2021) (10)
- Author Correction: RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia (2018) (10)
- DNA 5-Methylcytosine Specific Amplification and Sequencing. (2020) (9)
- An integrative analysis of genome-wide 5-hydroxymethylcytosines in circulating cell-free DNA detects noninvasive diagnostic markers for gliomas (2021) (9)
- [Studies on chemical constituents from herbs of Usnea longissima]. (2009) (9)
- Author Correction: Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion (2018) (8)
- Author response: YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs (2017) (8)
- Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation (2017) (8)
- Identifying the m6A Methylome by Affinity Purification and Sequencing. (2018) (8)
- 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic and predictive biomarkers for coronary artery disease (2020) (8)
- Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells. (2021) (7)
- Tethering-facilitated DNA ‘opening’ and complementary roles of β-hairpin motifs in the Rad4/XPC DNA damage sensor protein (2020) (7)
- Balance of DNA methylation and demethylation in cancer development (2012) (7)
- Transcriptome-wide profiling and quantification of N6-methyladenosine by enzyme-assisted adenosine deamination. (2023) (7)
- Viral RNA N6-methyladenosine modification modulates both innate and adaptive immune responses of human respiratory syncytial virus (2021) (7)
- Chromate Binding and Removal by the Molybdate‐Binding Protein ModA (2017) (7)
- 5-Hydroxymethylcytosine profiles of cfDNA are highly predictive of R-CHOP treatment response in diffuse large B cell lymphoma patients (2021) (6)
- Exon architecture controls mRNA m6A suppression and gene expression (2023) (6)
- High-Resolution Mapping of N 6-Methyladenosine Using m6A Crosslinking Immunoprecipitation Sequencing (m6A-CLIP-Seq). (2018) (6)
- Alterations of 5-hydroxymethylation in circulating cell-free DNA reflect molecular distinctions of subtypes of non-Hodgkin lymphoma (2021) (6)
- DNA cytosine hydroxymethylation levels are distinct among non-overlapping classes of peripheral blood leukocytes (2016) (5)
- KAS-seq: genome-wide sequencing of single-stranded DNA by N3-kethoxal–assisted labeling (2022) (5)
- Aberrant RNA methylation triggers recruitment of an alkylation repair complex. (2021) (5)
- Domains of methylated CAC and CG target MeCP2 to tune transcription in the brain (2016) (5)
- Small RNA profiling reveals involvement of microRNA-mediated gene regulation in response to mycorrhizal symbiosis in Poncirus trifoliata L. Raf. (2018) (5)
- YTHDF2 orchestrates tumor-associated macrophage reprogramming and controls antitumor immunity through CD8+ T cells (2023) (4)
- The 5-Hydroxymethylcytosine Landscape of Prostate Cancer (2022) (4)
- Making Changes: N6-Methyladenosine-Mediated Decay Drives the Endothelial-to-Hematopoietic Transition. (2017) (4)
- Preparation of Human Nuclear RNA m⁶A Methyltransferases and Demethylases and Biochemical Characterization of Their Catalytic Activity. (2015) (4)
- Impact of DNA sequences on DNA 'opening' by the Rad4/XPC nucleotide excision repair complex. (2021) (4)
- Aberrant RNA methylation triggers recruitment of an alkylation repair complex (2020) (4)
- Alterations of 5-hydroxymethylcytosines in circulating cell-free DNA reflect retinopathy in type 2 diabetes. (2020) (4)
- Cell-free DNA 5-hydroxymethylcytosine is an emerging marker of acute myeloid leukemia (2022) (3)
- The mechanism underlying redundant functions of the YTHDF proteins (2022) (3)
- Phasing Gene Expression: mRNA N6-Methyladenosine Regulates Temporal Progression of Mammalian Cortical Neurogenesis. (2018) (2)
- Correction to: YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma (2020) (2)
- FMRP phosphorylation modulates neuronal translation through YTHDF1 (2022) (2)
- 287-OR: M6A mRNA Methylation Regulates the Innate Immune Response in Human ß-Cells (2021) (2)
- Special Issue on Regulating the Central Dogma. (2019) (2)
- Author Correction: 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers (2019) (2)
- N6-methyladenosine binding proteins negatively regulate HIV-1 infectivity and viral production (2018) (2)
- 5-Hydroxymethylcytosines from Circulating Cell-free DNA as Diagnostic and Prognostic Markers for Hepatocellular Carcinoma (2018) (2)
- METTL14 is a chromatin regulator independent of its RNA N6-methyladenosine methyltransferase activity. (2023) (2)
- VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation (2018) (2)
- Author Correction: Kethoxal-assisted single-stranded DNA sequencing captures global transcription dynamics and enhancer activity in situ (2020) (1)
- INHIBITION OF BRD PROTEINS SUPPRESSES THE PHENOTYPE OF UTERINE FIBROIDS VIA REGULATION OF N6-METHYLADENOSINE REGULATORS (2021) (1)
- WITHDRAWN: ALKBHs-facilitated RNA modifications and de-modifications (2016) (1)
- mRNA acetylation: a new addition to the epitranscriptome (2019) (1)
- DNA 5-Hydroxymethylcytosines from Cell-free Circulating DNA as Diagnostic Biomarkers for Human Cancers (2017) (1)
- METTL4-mediated nuclear N6-deoxyadenosine methylation promotes metastasis through activating multiple metastasis-inducing targets (2022) (1)
- Genome-wide Analysis Reflects Novel 5-Hydroxymethylcytosines Implicated in Diabetic Nephropathy and the Biomarker Potential. (2022) (1)
- 5-Hydroxymethylcytosine of Circulating Cell-Free DNA in Plasma: A Novel Non-Invasive Marker for Progression and Prognosis in Multiple Myeloma (2017) (1)
- Development of Mild Chemical Catalysis Conditions for m1A-to-m6A Rearrangement on RNA. (2022) (1)
- N6-methyldeoxyadenosine directs nucleosome positioning in Tetrahymena DNA (2018) (1)
- N6-adenomethylation of GsdmC is essential for Lgr5+ stem cell survival to maintain normal colonic epithelial morphogenesis. (2022) (1)
- Retraction for Zhao et al., Pseudomonas aeruginosa Outer Membrane Vesicles Modulate Host Immune Responses by Targeting the Toll-Like Receptor 4 Signaling Pathway (2015) (1)
- spKAS-seq reveals R-loop dynamics using low-input materials by detecting single-stranded DNA with strand specificity (2022) (1)
- Abstract 3046: Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth (2015) (1)
- Chemical decaging in living systems. (2015) (1)
- 5-Hydroxymethylcytosine (5-hmC) Specific Enrichment. (2012) (1)
- Abstract 433: Genome-wide 5-hydroxymethylcytosine mapping in circulating cell-free DNA Identifies robust diagnostic markers for pancreatic adenocarcinoma (2019) (1)
- The chromatin organization of a chlorarachniophyte nucleomorph genome (2021) (1)
- N6-methyladenosine modification of HIV-1 RNA evades RIG-I-mediated sensing to suppresses type-I interferon induction in monocytic cells (2020) (1)
- Direct profiling of genome-wide dCas9 and Cas9 specificity using ssDNA mapping (CasKAS) (2021) (1)
- Author Correction: Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia (2018) (1)
- Reply to ‘Are the 5-hydroxymethylcytosine-based wd-scores really superior over α-fetoprotein for the early diagnosis of hepatocellular carcinoma?’ (2019) (1)
- 5-Hydroxymethylcytosines in circulating cell-free DNA and overall survival in patients with multiple myeloma. (2021) (1)
- Author Correction: An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease (2020) (1)
- A glance at N6-methyladenosine in transcript isoforms (2016) (1)
- Systematic identification of CRISPR off-target effects by CROss-seq (2022) (1)
- Abstract 4319: Hypoxia regulates m6A-reader YTHDF2 to fuel cancer-promoting inflammation in hepatocellular carcinoma (2019) (1)
- Impact of DNA sequences in the DNA duplex opening by the Rad4/XPC nucleotide excision repair complex (2020) (1)
- Transcriptome-Wide Detection of Internal N7-Methylguanosine. (2021) (1)
- Asymmetric Total Synthesis of (+)-Phainanoid A and Biological Evaluation of the Natural Product and Its Synthetic Analogues. (2023) (1)
- m 6 A RNA methylation regulates the UV-induced DNA damage response (2017) (1)
- ABERRANT EXPRESSION OF N6-METHYLADENOSINE REGULATORS IN UTERINE FIBROIDS FROM THE EKER RAT MODEL (2021) (1)
- 820 m6A mRNA demethylase FTO regulates tumorigenicity and response to anti-PD-1 immunotherapy in melanoma (2019) (1)
- N6-methyladenosine and Epitranscriptomic Regulation of Learning and Responses to Cocaine (2018) (0)
- Decoding the transcriptome and DNA methylome of human primordial germ cells (2015) (0)
- Author Correction: RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia (2018) (0)
- m6A mRNA methylation drives cardiomyocyte hypertrophy (2018) (0)
- Abstract 5711: Targeting FTO suppresses pancreatic carcinogenesis via cancer stem cell maintenance (2022) (0)
- KAS-pipe2: a flexible toolkit for exploring KAS-seq and spKAS-seq data (2022) (0)
- OGT binds a conserved C-terminal domain of TET 1 to regulate TET 1 activity and function in 1 development 2 3 (0)
- Redox Regulation of m6A Methyltransferase METTL3 in Human β-cells Controls the Innate Immune Response in Type 1 Diabetes (2023) (0)
- YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma (2019) (0)
- M6A demethylase ALKBH5 selectively promotes tumorigenesis and cancer stem cell self-renewal in acute myeloid leukemia (2020) (0)
- m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade (2019) (0)
- Author Correction: Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia (2018) (0)
- Abstract P5-04-09: Copper chaperons as novel targets for therapy in triple-negative breast cancer (TNBC) (2016) (0)
- 084 mRNA methylation in skin tumorigenesis and therapeutic resistance (2022) (0)
- RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia (2018) (0)
- 1 A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm Graphical (2018) (0)
- Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia (2017) (0)
- Mammalian DNA N6-methyladenosine: Challenges and new insights. (2023) (0)
- Discovery of synapse-specific RNA N6-methyladenosine readers associated with the consolidation of fear extinction memory (2022) (0)
- 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers (2017) (0)
- The METTL5-TRMT112 N6-methyladenosine methyltransferase complex regulates metabolism and development via translation (2021) (0)
- Sa1796 - 5-Hydroxymethylcytosine Profile from Plasma of Ulcerative Colitis and Crohn's Disease Patients as Novel Diagnostic Biomarkers (2018) (0)
- 5-Hydroxymethylcytosines of Circulating Cell-Free DNA and Prognosis in Diffuse Large B-Cell Lymphoma (2018) (0)
- A dynamic N6-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors (2018) (0)
- Abstract B67: Genome-wide 5-hydroxymethylcytosine mapping in circulating cell-free DNA reveals prognostic implications in pancreatic ductal adenocarcinoma (2020) (0)
- CasKAS: direct profiling of genome-wide dCas9 and Cas9 specificity using ssDNA mapping (2023) (0)
- Internal N6-methyladenosine modification controls the innate immune response to viral RNA (2020) (0)
- 6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda (2019) (0)
- Circulating tumor DNA 5-hydroxymethylcytosine as a novel diagnostic biomarker for esophageal cancer (2018) (0)
- Abstract B02: 5-Hydroxymethylcytosine profiles in circulating cell-free DNA are biomarkers of disease burden in children with neuroblastoma (2020) (0)
- Chemical methods to study protein-nucleic acid interactions. (2009) (0)
- Splice epitranscriptomics and DNA damage repair together: ALKBH5-m6A-SF3B1 regulation in leukemic transformation. (2023) (0)
- Visualizing a protein's sugars. (2014) (0)
- Acid Modifications with Epigenetic Significance (2012) (0)
- 5hmC Gene Signature Predicts the Treatment Response to Azacitidine with High-Dose Cytarabine and Mitoxantrone in AML (2021) (0)
- Model-based analysis of positive selection significantly expands the list of cancer driver genes, including RNA methyltransferases (2018) (0)
- Author Correction: TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells (2017) (0)
- 5-Hydroxymethylcytosine (5hmC) DNA Profiles Distinguish Malignant Colonocytes from Non-Neoplastic Colonocytes and Tumor-Associated Stromal Cells (2017) (0)
- Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis. (2019) (0)
- Fear extinction is regulated by long noncoding RNA activity at the synapse (2022) (0)
- Multi-cancer detection and tissue of origin determination based on 5-hydroxymethylcytosine biomarkers in circulating cell-free DNA. (2021) (0)
- RNA m6A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail (2019) (0)
- 304-OR: 5-Hydroxymethylcytosines in Circulating Cell-Free DNA Reveal Diabetic Nephropathy (2020) (0)
- 604 RNA methylation facilitates the repair of UV-induced DNA damage and suppresses photocarcinogenesis (2022) (0)
- Cell‐free DNA 5‐hydroxymethylcytosine as a marker for common cancer detection (2022) (0)
- N 6-methyladenosine modification and the YTHDF 2 reader protein play cell type 1 specific roles in lytic viral gene expression during Kaposi ’ s sarcoma-associated 2 herpesvirus infection 3 4 (2017) (0)
- Publisher Correction: TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells (2017) (0)
- The chromatin landscape of the euryarchaeon Haloferax volcanii (2023) (0)
- Compositions et procédés liés à la modification de 5-hydroxyméthylcytosine (5-hmc) (2011) (0)
- dynamic gene regulation Spatiotemporal clustering of the epigenome reveals rules of Material (2014) (0)
- Epitranscriptomic influences on development and disease (2017) (0)
- Protective effects of agmatine on severe trauma induced acute hepatic injury (2016) (0)
- Global Detection of RNA Methylation by Click Degradation (2020) (0)
- Abstract PR16: Whole-genome analysis of the epigenetic mark 5-hydroxymethylcytosine reveals differential profiles in low- , intermediate- , and high-risk neuroblastomas (2018) (0)
- TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells (2017) (0)
- Epigenetics: Making your mark on DNA. (2017) (0)
- Abstract IA008: Chromatin regulation by reversible chromatin-associated RNA methylation (2022) (0)
- The m6A methyltransferase METTL3 regulates muscle maintenance and growth in mice (2022) (0)
- Requirement for N6-Methyladenosine mRNA Methylation during Human Erythropoiesis (2022) (0)
- Author Correction: TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells (2017) (0)
- Abstract A17: Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth (2016) (0)
- Sa1740 – Spontaneous Mouse Colitis Produced by Deletion of Rna Methylation Writer Mettl14 in T Cells (2019) (0)
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