Cigall Kadoch
#115,217
Most Influential Person Now
American cancer biologist
Cigall Kadoch's AcademicInfluence.com Rankings
Cigall Kadochbiology Degrees
Biology
#9155
World Rank
#12325
Historical Rank
Genetics
#1806
World Rank
#1920
Historical Rank
Cigall Kadochphilosophy Degrees
Philosophy
#11687
World Rank
#16140
Historical Rank
Logic
#8488
World Rank
#10631
Historical Rank
Download Badge
Biology Philosophy
Cigall Kadoch's Degrees
- Bachelors Biological Sciences Stanford University
Why Is Cigall Kadoch Influential?
(Suggest an Edit or Addition)According to Wikipedia, Cigall Kadoch is an American biochemist and cancer biologist who is Associate Professor of Pediatric Oncology at the Dana–Farber Cancer Institute and Harvard Medical School and an Investigator at the Howard Hughes Medical Institute. Her research is focused in chromatin regulation and how changes in cellular structure can lead to human diseases, such as Cancer, Neurodevelopmental disorders, and others. She is internationally recognized for her work on the mammalian SWI/SNF complex, a large molecular machine known as a Chromatin remodeling complex. She was named as one of the world's leading scientists by MIT Technology Review, 35 Under 35 and Forbes 30 Under 30, and a Finalist for the Blavatnik Awards for Young Scientists. In 2019, she received the Martin and Rose Wachtel Cancer Research Prize from the American Association for the Advancement of Science and in 2020, the American Association for Cancer Research Outstanding Achievement in Basic Cancer Research Award. Kadoch was also recognized as one of the 100 Influential Women in Oncology by OncoDaily.
Cigall Kadoch's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy (2013) (999)
- Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics (2015) (571)
- Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes (2018) (363)
- Reversible Disruption of mSWI/SNF (BAF) Complexes by the SS18-SSX Oncogenic Fusion in Synovial Sarcoma (2013) (356)
- Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection (2020) (298)
- Cancer-Specific Retargeting of BAF Complexes by a Prion-like Domain (2017) (277)
- A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation (2018) (214)
- Dynamics of BAF- Polycomb Complex Opposition on Heterochromatin in Normal and Oncogenic States (2016) (193)
- CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma. (2013) (179)
- SMARCB1 is required for widespread BAF complex-mediated activation of enhancers and bivalent promoters (2017) (176)
- The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma. (2018) (149)
- Smarca4 ATPase mutations disrupt direct eviction of PRC1 from chromatin (2016) (146)
- Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer (2018) (145)
- Protein biomarker identification in the CSF of patients with CNS lymphoma. (2008) (140)
- Mammalian SWI/SNF complexes in cancer: emerging therapeutic opportunities. (2017) (124)
- Spliceosomal disruption of the non-canonical BAF complex in cancer (2019) (121)
- Chromatin regulatory mechanisms and therapeutic opportunities in cancer (2019) (118)
- Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens. (2018) (103)
- Multicenter phase 1 trial of intraventricular immunochemotherapy in recurrent CNS lymphoma. (2011) (101)
- PRC2 and SWI/SNF Chromatin Remodeling Complexes in Health and Disease. (2016) (99)
- Mammalian SWI/SNF Chromatin Remodeling Complexes: Emerging Mechanisms and Therapeutic Strategies. (2020) (95)
- ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer (2020) (87)
- A Novel SS18-SSX Fusion-specific Antibody for the Diagnosis of Synovial Sarcoma (2020) (78)
- Composition and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Disease. (2016) (73)
- The ATPase module of mammalian SWI/SNF family complexes mediates subcomplex identity and catalytic activity-independent genomic targeting (2019) (67)
- A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms (2020) (67)
- Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer. (2020) (67)
- TOP2 synergizes with BAF chromatin remodeling for both resolution and formation of facultative heterochromatin (2017) (63)
- Binding of TMPRSS2-ERG to BAF Chromatin Remodeling Complexes Mediates Prostate Oncogenesis. (2018) (62)
- Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling (2019) (59)
- Wiskott–Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma (2018) (48)
- Molecular pathogenesis of primary central nervous system lymphoma. (2006) (44)
- Pathologic Correlates of Primary Central Nervous System Lymphoma Defined in an Orthotopic Xenograft Model (2009) (41)
- Mammalian SWI/SNF Complex Genomic Alterations and Immune Checkpoint Blockade in Solid Tumors (2020) (38)
- Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma (2021) (37)
- Complement Activation and Intraventricular Rituximab Distribution in Recurrent Central Nervous System Lymphoma (2013) (37)
- ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression (2020) (36)
- Current state of pediatric sarcoma biology and opportunities for future discovery: A report from the sarcoma translational research workshop. (2016) (36)
- Biology and treatment of primary central nervous system lymphoma (2009) (33)
- Chromatin landscape signals differentially dictate the activities of mSWI/SNF family complexes (2021) (31)
- Differential gene expression in central nervous system lymphoma. (2009) (28)
- Polycomb and trithorax opposition in development and disease (2016) (28)
- Disruption of mammalian SWI/SNF and polycomb complexes in human sarcomas: mechanisms and therapeutic opportunities (2018) (26)
- Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition (2018) (26)
- Genomic and Immunologic Characterization of INI1-Deficient Pediatric Cancers (2020) (20)
- BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms. (2020) (19)
- The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma (2020) (19)
- Diverse compositions and functions of chromatin remodeling machines in cancer (2019) (14)
- A Two-Faced mSWI/SNF Subunit: Dual Roles for ARID1A in Tumor Suppression and Oncogenicity in the Liver. (2017) (9)
- OCT4 cooperates with distinct ATP-dependent chromatin remodelers in naïve and primed pluripotent states in human (2021) (9)
- SMARCE1 deficiency generates a targetable mSWI/SNF dependency in clear cell meningioma (2022) (7)
- A SMARCD2-containing mSWI/SNF complex is required for granulopoiesis (2017) (7)
- Abstract PR05: Reversing the oncogenic roles of misdirected chromatin remodeling: Disruption of mSWI/SNF (BAF) complexes by the SS18-SSX fusion in human synovial sarcoma (2013) (6)
- A pioneer factor locally opens compacted chromatin to enable targeted ATP-dependent nucleosome remodeling (2022) (5)
- When prostate brachytherapy fails: a case report and discussion. (2005) (4)
- Lifting Up the HAT: Synthetic Lethal Screening Reveals a Novel Vulnerability at the CBP-p300 Axis. (2016) (4)
- The FUS::DDIT3 fusion oncoprotein inhibits BAF complex targeting and activity in myxoid liposarcoma. (2022) (3)
- Abstract PR09: Cancer-specific retargeting of BAF complexes by a prion-like domain (2018) (3)
- Structure and Function of ATP-Dependent Chromatin Remodeling Complexes in Human Cancer (2019) (2)
- Synthesis of Oriented Hexasomes and Asymmetric Nucleosomes Using a Template Editing Process. (2022) (2)
- Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling (2020) (2)
- Alcohol as a potential contributing factor in radiation complications. (2009) (2)
- Abstract PR11: SSX-mediated chromatin engagement and targeting of BAF complexes activates oncogenic transcription in synovial sarcoma (2018) (1)
- Spliceosomal Disruption of the Non-Canonical SWI/SNF Chromatin Remodeling Complex in SF3B1 Mutant Leukemias (2019) (1)
- Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection (2023) (1)
- Abstract 3875: SSX drives gain-of-function BAF complex chromatin affinity and genomic targeting in synovial sarcoma (2017) (1)
- Abstract 2728: Multivariate analysis of cerebrospinal fluid protein biomarkers in central nervous system lymphoma patients and controls (2010) (1)
- Abstract 949: ARID1A is a critical regulator of luminal identity and therapeutic response in estrogen receptor-positive breast cancer (2019) (1)
- Targeting NF-KB Activation in Novel Intracranial Models of CNS Lymphoma (2016) (1)
- Novel Intracranial Xenografts Of CNS Lymphoma Implicate a Role For Cereblon As a Mediator Of Lenalidomide Efficacy (2013) (1)
- Reply to H. Zetterberg et al (2009) (1)
- Opposing immune and genetic forces shape oncogenic programs in synovial sarcoma (2019) (1)
- Dynamic Changes in Macrophage Polarization Correlate with Progression and Response in CNS Lymphoma: Insights Into the Transcriptome of Lymphoma-Associated M2 Macrophages, (2011) (1)
- Chromatin regulatory mechanisms and therapeutic opportunities in cancer (2019) (1)
- Complement Activation and Resistance within the Cerebrospinal Fluid Following Intraventricular Administration of Anti-CD20 in the Treatment of Recurrent CNS Lymphoma. (2007) (1)
- A functional mammalian display screen identifies rare antibodies that stimulate NK cell–mediated cytotoxicity (2021) (0)
- Genomic and Molecular Properties of Relapsed CNS Lymphoma Using Novel Primary Meningeal Lymphoma Cell Lines and Intracranial Xenografts (2011) (0)
- Non-Hodgkin’s lymphoma of the brainstem: a case report and discussion. (2006) (0)
- Structure and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Disease (2019) (0)
- Abstract B17: Identification of Druggable Targets through Functional Multi-Omics in Renal Medullary Carcinoma (2017) (0)
- The Baf Subunit Dpf2 Regulates Resolution of Inflammation By Controlling Macrophage Differentiation Transcription Factor Networks (2020) (0)
- Reversing the oncogenic roles of misdirected chromatin remodeling: Mechanistic insights into the SS18-SSX fusion protein in synovial sarcoma. (2013) (0)
- Spliceosomal disruption of the non-canonical BAF complex in cancer (2019) (0)
- Interim results of a phase I trial of intraventricular rituximab plus methotrexate in recurrent CNS lymphoma: Macrophage polarization and acquired resistance to therapy. (2010) (0)
- Abstract 2315: Reversible disruption of mSWI/SNF-like BAF complexes by the SS18-SSX oncogenic fusion in synovial sarcoma. (2013) (0)
- Abstract PR15: BRD9 defines a novel mammalian SWI/SNF (BAF) complex configuration which supports proliferation in AML (2017) (0)
- Application of Hyperpolarized 13C Magnetic Resonance Imaging to Detect Target Inhibition of NFkB Activation in Preclinical Patient-Derived Models of CNS Lymphoma (2018) (0)
- The ATPase module of mammalian SWI/SNF family complexes mediates subcomplex identity and catalytic activity–independent genomic targeting (2019) (0)
- Abstract 5559: Using cancer dependency data to discover tumor suppressive and oncogenic functional modules (2017) (0)
- Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustion (2023) (0)
- Abstract 802: Loss of function of Arid1a synergizes with MYCN in neuroblastoma pathogenesis (2017) (0)
- Abstract 5580: Macrophage polarization and acquired resistance to rituximab in CNS lymphoma (2010) (0)
- Abstract 1020: BRD9 defines a novel mammalian SWI/SNF (BAF) complex configuration which supports proliferation in AML (2017) (0)
- Identification of CSF Biomarkers for the Diagnosis of CNS Lymphoma. (2006) (0)
- Abstract 1653: Application of high-density tiling CRISPR screen technology to identify chromatin remodeler complex targets for drug discovery (2019) (0)
- Complement Activation and Intraventricular Rituximab Distribution inRecurrentCentral NervousSystemLymphoma (2014) (0)
- Macrophage Polarization and Acquired Resistance to Rituximab in CNS Lymphoma. (2009) (0)
- ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer (2020) (0)
- Abstract 882: TMPRSS2-ERG drives global mistargeting of mammalian SWI/SNF (BAF) complexes in prostate cancer (2016) (0)
- Abstract B18: Modeling renal medullary carcinomas identifies druggable vulnerabilities in SMARCB1-deficient cancers (2018) (0)
- Wiskott–Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma (2018) (0)
- Abstract 290: Development and characterization of antibodies specific for the SS18-SSX fusion protein in synovial sarcoma (2020) (0)
- Abstract 2658: Genome-wide mistargeting of oncogenic SWI/SNF(BAF) complexes in SMARCB1(BAF47)-deficient sarcomas (2016) (0)
- Author Correction: The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma (2020) (0)
- Abstract 1794: Targeting mammalian SWI/SNF chromatin remodeling complexes to improve T cell-based cancer immunotherapies (2023) (0)
- Faculty Opinions recommendation of Allosteric activation dictates PRC2 activity independent of its recruitment to chromatin. (2018) (0)
- G enitourinary C ancer When Prostate Brachytherapy Fails: A Case Report and Discussion (2005) (0)
- Structural and functional properties of mSWI/SNF chromatin remodeling complexes revealed through single-cell perturbation screens. (2023) (0)
- Abstract 3485: Intrinsically disordered regions of the ARID1A/B tumor suppressors encode an interaction network within biomolecular condensates that directs mSWI/SNF chromatin remodeler complex activity (2023) (0)
- SMARCB1 nucleosome-interacting C-terminal alpha helix (2019) (0)
- Abstract A16: Genomic and immunologic characterization of a cohort of INI1-deficient pediatric cancers (2020) (0)
- A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation (2018) (0)
- First Rounders: Cigall Kadoch (2019) (0)
- Kinase-independent activity of DYRK1A promotes viral entry of highly pathogenic human coronaviruses (2022) (0)
- Faculty Opinions recommendation of RNA Interactions Are Essential for CTCF-Mediated Genome Organization. (2019) (0)
- Abstract IA30: BAF complex structure and function in development and disease (2016) (0)
- Abstract 907: Bioinformatic method to define epigenetically regulated enhancer elements associated with cancer (2019) (0)
- The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma (2020) (0)
- Intellectual disability-associated SMARCB1 mutations reveal a nucleosome acidic patch interaction site that potentiates mSWI/SNF chromatin remodeling (2020) (0)
This paper list is powered by the following services:
Other Resources About Cigall Kadoch
What Schools Are Affiliated With Cigall Kadoch?
Cigall Kadoch is affiliated with the following schools:
