Claudio Franceschi
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Philosophy
Claudio Franceschi's Degrees
- PhD Biomedical Sciences University of Bologna
- Doctorate Medicine University of Bologna
Why Is Claudio Franceschi Influential?
(Suggest an Edit or Addition)Claudio Franceschi's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Inflamm‐aging: An Evolutionary Perspective on Immunosenescence (2000) (3720)
- Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. (2014) (2422)
- Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans (2007) (1762)
- Chronic inflammation in the etiology of disease across the life span (2019) (1434)
- Geroscience: Linking Aging to Chronic Disease (2014) (1391)
- Inflammaging: a new immune–metabolic viewpoint for age-related diseases (2018) (1180)
- Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians (2010) (1150)
- A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolcarbocyanine iodide (JC-1). (1993) (1039)
- JC‐1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess ΔΨ changes in intact cells: implications for studies on mitochondrial functionality during apoptosis (1997) (991)
- Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes? (2018) (746)
- Increased cytokine production in mononuclear cells of healthy elderly people (1993) (632)
- Gut Microbiota and Extreme Longevity (2016) (534)
- The immunology of exceptional individuals: the lesson of centenarians. (1995) (519)
- Inflammaging and ‘Garb-aging’ (2017) (515)
- Shortage of circulating naive CD8(+) T cells provides new insights on immunodeficiency in aging. (2000) (496)
- Interventions to Slow Aging in Humans: Are We Ready? (2015) (462)
- The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates (2018) (459)
- Innate immunity and inflammation in ageing: a key for understanding age-related diseases (2005) (458)
- Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space. (2000) (453)
- Inflamm‐ageing and lifelong antigenic load as major determinants of ageing rate and longevity (2005) (446)
- Mitochondria are selective targets for the protective effects of heat shock against oxidative injury. (1996) (419)
- Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans. (2003) (417)
- Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice (2005) (410)
- Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans (1999) (394)
- The immune system in extreme longevity (2008) (393)
- Inflammaging as a major characteristic of old people: can it be prevented or cured? (2007) (387)
- Accelerated epigenetic aging in Down syndrome (2015) (381)
- A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. (2005) (353)
- Expansion of cytotoxic CD8+ CD28− T cells in healthy ageing people, including centenarians (1996) (342)
- Centenarians as a model for healthy aging. (2003) (341)
- T cells and aging, January 2002 update. (2002) (328)
- Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence (2017) (327)
- Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries (2020) (326)
- Methylation of ELOVL2 gene as a new epigenetic marker of age (2012) (326)
- Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control. (2003) (321)
- Inflammation markers predicting frailty and mortality in the elderly. (2006) (320)
- The aging thyroid. (1995) (319)
- Undulating changes in human plasma proteome profiles across the lifespan (2019) (317)
- Aging of the immune system as a prognostic factor for human longevity. (2008) (316)
- The network and the remodeling theories of aging: historical background and new perspectives (2000) (313)
- Ageing of the human metaorganism: the microbial counterpart (2011) (310)
- A gender–dependent genetic predisposition to produce high levels of IL‐6 is detrimental for longevity (2001) (303)
- Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons. (2003) (302)
- The neuroimmunology of stress from invertebrates to man (1996) (300)
- Protective effect of N-acetylcysteine in tumor necrosis factor-alpha-induced apoptosis in U937 cells: the role of mitochondria. (1995) (297)
- Plasma antioxidants and longevity: a study on healthy centenarians. (2000) (288)
- Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition (2017) (283)
- Risk factors and incidence of postoperative delirium in elderly patients after elective and emergency surgery (2010) (271)
- Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for “inflamm‐aging” (2014) (260)
- Functional metagenomic profiling of intestinal microbiome in extreme ageing (2013) (257)
- Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring (2015) (244)
- Do men and women follow different trajectories to reach extreme longevity? (2000) (242)
- Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age (2014) (238)
- CD45 isoforms expression on CD4+ and CD8+ T cells throughout life, from newborns to centenarians: implications for T cell memory (1996) (235)
- Vaccination in the elderly: The challenge of immune changes with aging. (2018) (232)
- Aging and Parkinson's Disease: Inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis (2018) (228)
- The Three Genetics (Nuclear DNA, Mitochondrial DNA, and Gut Microbiome) of Longevity in Humans Considered as Metaorganisms (2014) (227)
- Gender-specific association between −1082 IL-10 promoter polymorphism and longevity (2002) (227)
- Complex alteration of thyroid function in healthy centenarians. (1993) (224)
- The immune system in the elderly (2004) (220)
- Identification of a geographic area characterized by extreme longevity in the Sardinia island: the AKEA study (2004) (220)
- Correction: Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians (2010) (219)
- Ageing and gut microbes: perspectives for health maintenance and longevity. (2013) (219)
- Thyroid and other organ-specific autoantibodies in healthy ceritenarians (1992) (215)
- Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile (2013) (213)
- Inflamm-aging, cytokines and aging: state of the art, new hypotheses on the role of mitochondria and new perspectives from systems biology. (2006) (212)
- Aging, Longevity, Inflammation, and Cancer (2004) (212)
- Reconfiguration of DNA methylation in aging (2015) (212)
- Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians (2005) (207)
- The Genetics of Human Longevity (2006) (203)
- Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism (2013) (200)
- Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains (2006) (200)
- Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging (2012) (199)
- Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence (2003) (197)
- N-glycomic biomarkers of biological aging and longevity: A link with inflammaging (2013) (195)
- Oxidative stress and the ageing endocrine system (2013) (195)
- Mitochondrial modifications during rat thymocyte apoptosis: a study at the single cell level. (1994) (192)
- Inflamm-ageing (2013) (189)
- Lipoprotein(a) and lipoprotein profile in healthy centenarians: a reappraisal of vascular risk factors (1998) (189)
- Immunosenescence and Immunogenetics of Human Longevity (2008) (188)
- Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians’ offspring (2013) (186)
- MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling (2013) (182)
- Interleukin-6 gene alleles affect the risk of Alzheimer’s disease and levels of the cytokine in blood and brain (2003) (182)
- Immune system, cell senescence, aging and longevity--inflamm-aging reappraised. (2013) (180)
- Massive Load of Functional Effector CD4+ and CD8+ T Cells against Cytomegalovirus in Very Old Subjects1 (2007) (179)
- MARK-AGE biomarkers of ageing (2015) (179)
- Inflammation, genetics, and longevity: further studies on the protective effects in men of IL-10 −1082 promoter SNP and its interaction with TNF-α −308 promoter SNP (2003) (177)
- Fibroblast cultures from healthy centenarians have an active proteasome (2000) (177)
- Genome‐wide linkage analysis for human longevity: Genetics of Healthy Aging Study (2013) (174)
- Mitochondrial DNA haplogroups and APOE4 allele are non-independent variables in sporadic Alzheimer's disease (2001) (173)
- MicroRNAs linking inflamm-aging, cellular senescence and cancer (2013) (172)
- Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes (2003) (171)
- Cytomegalovirus Infection (2007) (171)
- Gender, aging and longevity in humans: an update of an intriguing/neglected scenario paving the way to a gender-specific medicine (2016) (168)
- Immunobiography and the Heterogeneity of Immune Responses in the Elderly: A Focus on Inflammaging and Trained Immunity (2017) (167)
- The invertebrate phagocytic immunocyte: clues to a common evolution of immune and neuroendocrine systems. (1997) (161)
- Extremely low frequency pulsed electromagnetic fields increase cell proliferation in lymphocytes from young and aged subjects. (1989) (160)
- Mitochondrial membrane potential and DNA stainability in human sperm cells: a flow cytometry analysis with implications for male infertility. (1998) (159)
- THYMIC HORMONE DEFICIENCY IN NORMAL AGEING AND DOWN'S SYNDROME: IS THERE A PRIMARY FAILURE OF THE THYMUS? (1984) (159)
- A meta-analysis of genome-wide association studies identifies multiple longevity genes (2019) (158)
- Increased brain-predicted aging in treated HIV disease (2017) (158)
- The treatment of osteosarcoma of the extremities: Twenty year's experience at the istituto ortopedico rizzoli (1981) (153)
- Age-related inflammation: the contribution of different organs, tissues and systems. How to face it for therapeutic approaches. (2010) (153)
- Biomarkers of immunosenescence within an evolutionary perspective: the challenge of heterogeneity and the role of antigenic load (1999) (145)
- Low vitamin D status, high bone turnover, and bone fractures in centenarians. (2003) (144)
- Chemokines, sTNF-Rs and sCD30 serum levels in healthy aged people and centenarians (2001) (144)
- Gut microbiota changes in the extreme decades of human life: a focus on centenarians (2017) (144)
- Inflammaging and Cancer: A Challenge for the Mediterranean Diet (2015) (143)
- Genes, demography, and life span: the contribution of demographic data in genetic studies on aging and longevity. (1999) (143)
- A Cross-Sectional Analysis of Body Composition Among Healthy Elderly From the European NU-AGE Study: Sex and Country Specific Features (2018) (140)
- HAPLOFIND: A New Method for High‐Throughput mtDNA Haplogroup Assignment (2013) (137)
- What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment? (2005) (137)
- Novel loci and pathways significantly associated with longevity (2016) (136)
- Cytometric analysis of immunosenescence. (1997) (132)
- Opposite effects of interleukin 10 common gene polymorphisms in cardiovascular diseases and in successful ageing: genetic background of male centenarians is protective against coronary heart disease (2004) (132)
- Changes in circuIating B cells and immunoglobulin cIasses and subcIasses in a healthy aged popuIation (1992) (131)
- Immunogenetics, Gender, and Longevity (2006) (131)
- Gene polymorphism affecting α1‐antichymotrypsin and interleukin‐1 plasma levels increases Alzheimer's disease risk (2000) (130)
- Interleukin-10 promoter polymorphism in sporadic Alzheimer's disease (2003) (130)
- New advances in CMV and immunosenescence (2014) (130)
- Role of Toll-like receptor 4 in acute myocardial infarction and longevity. (2004) (129)
- Mitochondria alterations and dramatic tendency to undergo apoptosis in peripheral blood lymphocytes during acute HIV syndrome (1997) (129)
- Apoptosis‐like, reversible changes in plasma membrane asymmetry and permeability, and transient modifications in mitochondrial membrane potential induced by curcumin in rat thymocytes (1998) (128)
- Paradoxes in longevity: sequence analysis of mtDNA haplogroup J in centenarians (2001) (127)
- Curcumin in Cell Death Processes: A Challenge for CAM of Age-Related Pathologies (2007) (126)
- Diverse Effect of Inflammatory Markers on Insulin Resistance and Insulin‐Resistance Syndrome in the Elderly (2004) (124)
- Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2) (1998) (123)
- A Study of Serum Immunoglobulin Levels in Elderly Persons That Provides New Insights into B Cell Immunosenescence (2006) (123)
- What evidence is there for the existence of individual genes with antagonistic pleiotropic effects? (2005) (121)
- Inflammaging and human longevity in the omics era (2017) (119)
- Different contribution of EBV and CMV infections in very long-term carriers to age-related alterations of CD8+ T cells (2004) (118)
- Evidence for Sub-Haplogroup H5 of Mitochondrial DNA as a Risk Factor for Late Onset Alzheimer's Disease (2010) (118)
- Extremely low frequency pulsed electromagnetic fields increase interleukin‐2 (IL‐2) utilization and IL‐2 receptor expression in mitogen‐stimulated human lymphocytes from old subjects (1989) (117)
- Aging and Imaging Assessment of Body Composition: From Fat to Facts (2020) (117)
- Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity (2015) (117)
- Combating inflammaging through a Mediterranean whole diet approach: The NU-AGE project's conceptual framework and design (2014) (116)
- Precocious aging of the immune system in Down syndrome: alteration of B lymphocytes, T-lymphocyte subsets, and cells with natural killer markers. (2005) (116)
- Cell proliferation, cell death and aging (1989) (116)
- Vitamin E–gene interactions in aging and inflammatory age-related diseases: Implications for treatment. A systematic review (2014) (115)
- Age-dependent modifications of Type 1 and Type 2 cytokines within virgin and memory CD4+ T cells in humans (2006) (114)
- The G/C915 polymorphism of transforming growth factor β1 is associated with human longevity: a study in Italian centenarians (2004) (113)
- Inhibition of apoptosis by zinc: a reappraisal. (1992) (112)
- Resistance to apoptosis in CTLL-2 cells constitutively expressing c-Myb is associated with induction of BCL-2 expression and Myb-dependent regulation of bcl-2 promoter activity. (1997) (112)
- In Vitro Exposure of Human Lymphocytes to 900 MHz CW and GSM Modulated Radiofrequency: Studies of Proliferation, Apoptosis and Mitochondrial Membrane Potential (2004) (112)
- Human aging and longevity are characterized by high levels of mitokines. (2018) (112)
- Telomere length in fibroblasts and blood cells from healthy centenarians. (1999) (111)
- Thymic output and functionality of the IL‐7/IL‐7 receptor system in centenarians: implications for the neolymphogenesis at the limit of human life (2006) (110)
- Mediterranean diet and inflammaging within the hormesis paradigm (2017) (110)
- Allele frequencies of +874T→A single nucleotide polymorphism at the first intron of interferon-γ gene in a group of Italian centenarians (2002) (110)
- Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia (2011) (109)
- Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity (2014) (108)
- Age-dependent alteration in muscle regeneration: the critical role of tissue niche (2013) (107)
- An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging (2021) (106)
- Age-related expansion of functionally inefficient cells with markers of natural killer activity in Down's syndrome. (1991) (106)
- Serum N-glycan profile shift during human ageing (2010) (105)
- Human intestinal microbiota: cross-talk with the host and its potential role in colorectal cancer (2011) (105)
- Long-term immune-endocrine effects of bereavement: relationships with anxiety levels and mood (2003) (104)
- Apoptosis and spermatogenesis: evidence from an in vivo model of testosterone withdrawal in the adult rat. (1994) (102)
- AKEntAnnos. The Sardinia Study of Extreme Longevity (1999) (102)
- Gene polymorphisms predicting high plasma levels of coagulation and fibrinolysis proteins. A study in centenarians. (1997) (102)
- N-glycomic changes in serum proteins during human aging. (2007) (102)
- Long-term immunologic effects of thymectomy in patients with myasthenia gravis. (1999) (101)
- Mitochondria, aging and longevity – a new perspective (2001) (101)
- Genetics of Healthy Aging in Europe (2007) (101)
- The −174 C/G locus affects in vitro/in vivo IL-6 production during aging (2002) (101)
- Oxygen radicals induce stress proteins and tolerance to oxidative stress in human lymphocytes. (1996) (100)
- The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death (2004) (99)
- Autocrine nerve growth factor protects human keratinocytes from apoptosis through its high affinity receptor (TRK): a role for BCL-2. (1997) (99)
- Association of the mitochondrial DNA haplogroup J with longevity is population specific (2004) (99)
- Identifying the genomic determinants of aging and longevity in human population studies: Progress and challenges (2013) (98)
- Is Aging As Complex As It Would Appear? (1992) (97)
- Metallothioneins/PARP-1/IL-6 interplay on natural killer cell activity in elderly: parallelism with nonagenarians and old infected humans. Effect of zinc supply (2003) (97)
- Exposure to low frequency pulsed electromagnetic fields increases interleukin-1 and interleukin-6 production by human peripheral blood mononuclear cells. (1993) (97)
- Hemopoiesis in healthy old people and centenarians: well-maintained responsiveness of CD34+ cells to hemopoietic growth factors and remodeling of cytokine network. (2000) (97)
- Earthworm leukocytes that are not phagocytic and cross-react with several human epitopes can kill human tumor cell lines. (1996) (97)
- Gene expression changes in human cells after exposure to mobile phone microwaves (2006) (96)
- Metabolic age modelling: the lesson from centenarians (2000) (95)
- Pro-opiomelanocortin-derived peptides, cytokines, and nitric oxide in immune responses and stress: an evolutionary approach. (1997) (95)
- The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific (2013) (95)
- The aging gut microbiota: New perspectives (2011) (95)
- Effect of interleukin-6 polymorphisms on human longevity: A systematic review and meta-analysis (2009) (94)
- C60 carboxyfullerene exerts a protective activity against oxidative stress-induced apoptosis in human peripheral blood mononuclear cells. (2000) (94)
- -174 G>C polymorphism of interleukin 6 gene promoter affects interleukin 6 serum level in patients with colorectal cancer. (2003) (93)
- Effect of Etanercept on Insulin Sensitivity in Nine Patients with Psoriasis (2007) (93)
- In vivo accumulation of sulfated glycoprotein 2 mRNA in rat thymocytes upon dexamethasone-induced cell death. (1991) (92)
- Age- and glycemia-related miR-126-3p levels in plasma and endothelial cells (2014) (92)
- From lifetime to evolution: timescales of human gut microbiota adaptation (2014) (92)
- The −174G/C polymorphism of IL-6 is useful to screen old subjects at risk for atherosclerosis or to reach successful ageing (2004) (92)
- Serum IL-1beta levels in health and disease: a population-based study. 'The InCHIANTI study'. (2003) (92)
- The A3 adenosine receptor mediates cell spreading, reorganization of actin cytoskeleton, and distribution of Bcl-XL: studies in human astroglioma cells. (1997) (91)
- Apoptosis--programmed cell death: a role in the aging process? (1992) (91)
- In vitro peroxidase oxidation induces stable dimers of beta-amyloid (1-42) through dityrosine bridge formation. (1999) (91)
- Impact of personalized diet and probiotic supplementation on inflammation, nutritional parameters and intestinal microbiota - The "RISTOMED project": Randomized controlled trial in healthy older people. (2015) (90)
- Discovery of novel and selective SIRT6 inhibitors. (2014) (89)
- Leukocyte telomere length is associated with complications of Type 2 diabetes mellitus (2011) (88)
- Identification of a DNA methylation signature in blood cells from persons with Down Syndrome (2014) (87)
- Corticotropin-releasing hormone modulates cytokines release in cultured human peripheral blood mononuclear cells. (1993) (87)
- Modulation of Apoptosis by Adenosine in the Central Nervous System: a Possible Role for the A3 Receptor (1997) (87)
- A novel action for adenosine: apoptosis of astroglial cells in rat brain primary cultures. (1995) (86)
- 1800 MHz radiofrequency (mobile phones, different Global System for Mobile communication modulations) does not affect apoptosis and heat shock protein 70 level in peripheral blood mononuclear cells from young and old donors (2004) (85)
- Intense Antiextracellular Adaptive Immune Response to Human Cytomegalovirus in Very Old Subjects with Impaired Health and Cognitive and Functional Status (2010) (85)
- Pathophysiology of ageing, longevity and age related diseases (2007) (85)
- Neuroinflammation and the genetics of Alzheimer’s disease: The search for a pro-inflammatory phenotype (2001) (85)
- N-Glycomic Changes in Serum Proteins in Type 2 Diabetes Mellitus Correlate with Complications and with Metabolic Syndrome Parameters (2015) (84)
- Genes and longevity: lessons from studies of centenarians. (2000) (84)
- Presence of ACTH and β-endorphin immunoreactive molecules in the freshwater snail Planorbarius corneus (L.) (Gastropoda, Pulmonata) and their possible role in phagocytosis (1990) (84)
- Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells (2020) (83)
- Family clustering in Sardinian longevity: A genealogical approach (2006) (83)
- Deficiency of autologous mixed lymphocyte reactions and serum thymic factor level in Down's syndrome. (1981) (83)
- Association between the interleukin-1β polymorphisms and Alzheimer's disease: A systematic review and meta-analysis (2008) (83)
- Retention of the p53 codon 72 arginine allele is associated with a reduction of disease-free and overall survival in arginine/proline heterozygous breast cancer patients. (2003) (83)
- HLA, aging, and longevity: a critical reappraisal. (2000) (83)
- Present and future of anti-ageing epigenetic diets (2014) (83)
- Inflamm-aging of the stem cell niche: breast cancer as a paradigmatic example: breakdown of the multi-shell cytokine network fuels cancer in aged people. (2012) (82)
- The evolution of the adipose tissue: a neglected enigma. (2011) (82)
- Immunoproteasomes and immunosenescence (2003) (82)
- Systematic review by meta-analyses on the possible role of TNF-α polymorphisms in association with Alzheimer's disease (2009) (82)
- Have the oldest old adults ever been frail in the past? A hypothesis that explains modern trends in survival. (2001) (82)
- Von Willebrand factor in Italian centenarians. (2003) (81)
- Numerical and functional alterations of circulating γδ T lymphocytes in aged people and centenarians (2002) (81)
- Presence of several cytokine-like molecules in molluscan hemocytes. (1993) (80)
- Low circulating IGF-I bioactivity is associated with human longevity: Findings in centenarians’ offspring (2012) (80)
- Association between longevity and cytokine gene polymorphisms. A study in Sardinian centenarians (2004) (79)
- Decreased susceptibility to oxidative stress-induced apoptosis of peripheral blood mononuclear cells from healthy elderly and centenarians (2001) (79)
- The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: A systems biology approach (2014) (79)
- Carboxyfullerenes protect human keratinocytes from ultraviolet-B-induced apoptosis. (2000) (78)
- Network, degeneracy and bow tie. Integrating paradigms and architectures to grasp the complexity of the immune system (2010) (78)
- Perilipin 2 and Age-Related Metabolic Diseases: A New Perspective (2016) (78)
- Circulating levels of adipokines and IGF-1 are associated with skeletal muscle strength of young and old healthy subjects (2013) (78)
- Mitochondrial DNA involvement in human longevity. (2006) (77)
- Elevated plasma homocysteine levels in centenarians are not associated with cognitive impairment (2001) (77)
- Inherited Variability of the Mitochondrial Genome and Successful Aging in Humans (2000) (76)
- Genes, ageing and longevity in humans: Problems, advantages and perspectives (2006) (76)
- The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity (2019) (75)
- Complexity of anti-immunosenescence strategies in humans. (2006) (75)
- The unusual genetics of human longevity. (2006) (75)
- The interleukin-6 -174 G>C promoter polymorphism is associated with a higher risk of death after an acute coronary syndrome in male elderly patients. (2005) (74)
- Acceleration of leukocytes’ epigenetic age as an early tumor and sex-specific marker of breast and colorectal cancer (2017) (74)
- Do people living with HIV experience greater age advancement than their HIV-negative counterparts? (2018) (74)
- Mitochondrial heterogeneity during staurosporine-induced apoptosis in HL60 cells: analysis at the single cell and single organelle level. (2000) (74)
- Mediterranean-Style Diet Improves Systolic Blood Pressure and Arterial Stiffness in Older Adults (2019) (74)
- Apoptosis by 2-chloro-2′-deoxy-adenosine and 2-chloro-adenosine in human peripheral blood mononuclear cells (1998) (74)
- Immunogenetics of longevity. Is major histocompatibility complex polymorphism relevant to the control of human longevity? A review of literature data (2001) (73)
- Gut microbiota as a candidate for lifespan extension: an ecological/evolutionary perspective targeted on living organisms as metaorganisms (2011) (73)
- Activation of the A3 adenosine receptor affects cell cycle progression and cell growth (2000) (73)
- The highly reducing sugar 2-deoxy-D-ribose induces apoptosis in human fibroblasts by reduced glutathione depletion and cytoskeletal disruption. (1998) (72)
- Low insulin resistance and preserved β-cell function contribute to human longevity but are not associated with TH–INS genes (2001) (72)
- Inhibin and activin modulate human monocyte chemotaxis and human lymphocyte interferon-gamma production. (1991) (72)
- Elevated gut microbiome abundance of Christensenellaceae, Porphyromonadaceae and Rikenellaceae is associated with reduced visceral adipose tissue and healthier metabolic profile in Italian elderly (2021) (71)
- The extreme longevity: The state of the art in Italy (2008) (71)
- The frequency of Klotho KL-VS polymorphism in a large Italian population, from young subjects to centenarians, suggests the presence of specific time windows for its effect (2010) (71)
- Why do centenarians escape or postpone cancer? The role of IGF-1, inflammation and p53 (2009) (71)
- Immunosenescence in humans: deterioration or remodelling? (1995) (71)
- Metformin improves putative longevity effectors in peripheral mononuclear cells from subjects with prediabetes. A randomized controlled trial. (2015) (71)
- Apoptosis of skeletal and cardiac muscles and physical exercise (1997) (71)
- Handbook on immunosenescence : basic understanding and clinical applications (2009) (71)
- The genetics of human longevity: an intricacy of genes, environment, culture and microbiome (2017) (69)
- Human longevity and 11p15.5: a study in 1321 centenarians (2009) (69)
- Autogeneic but not allogeneic earthworm effector coelomocytes kill the mammalian tumor cell target K562. (1995) (69)
- Mitochondrial DNA Backgrounds Might Modulate Diabetes Complications Rather than T2DM as a Whole (2011) (69)
- Gut microbiota and osteoarthritis management: An expert consensus of the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO) (2019) (69)
- Male/female ratio in centenarians: a possible role played by population genetic structure (2002) (69)
- Genomic Instability and Aging (1992) (69)
- Massive activation of immune cells with an intact T cell repertoire in acute human immunodeficiency virus syndrome. (1995) (69)
- Mutant factor V (Arg506Gln) in healthy centenarians (1996) (69)
- Invertebrate and Vertebrate Immune Cells Express Pro-opiomelanocortin (POMC) mRNA (1995) (69)
- Spontaneous and mitomycin-C-induced micronuclei in human lymphocytes exposed to extremely low frequency pulsed magnetic fields. (1991) (68)
- Mitochondria hyperfusion and elevated autophagic activity are key mechanisms for cellular bioenergetic preservation in centenarians (2014) (68)
- Oral zinc supplementation in Down's syndrome: restoration of thymic endocrine activity and of some immune defects. (2008) (68)
- Inflammaging 2018: An update and a model. (2018) (68)
- Paraoxonase polymorphisms PON1 192 and 55 and longevity in Italian centenarians and Irish nonagenarians. A pooled analysis (2004) (67)
- Immunoproteasome LMP2 60HH Variant Alters MBP Epitope Generation and Reduces the Risk to Develop Multiple Sclerosis in Italian Female Population (2010) (67)
- Age‐related changes of the 3′APOB‐VNTR genotype pool in ageing cohorts (1998) (67)
- Lamins are rapamycin targets that impact human longevity: a study in centenarians (2014) (66)
- Systems biology and longevity: an emerging approach to identify innovative anti-aging targets and strategies. (2010) (66)
- Common evolutionary origin of the immune and neuroendocrine systems: from morphological and functional evidence to in silico approaches. (2007) (66)
- Human Immunosenescence (2006) (66)
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- Estrogen Containing Hormone Replacement Therapy Affects MicroRNAs And Fas/FasL In Genetically Identical Female Twin Pairs: 85 Board #6 May 28, 9 (2014) (1)
- Author Correction: Sarcolab pilot study into skeletal muscle’s adaptation to longterm spaceflight (2018) (1)
- Accelerated biological aging in people with Down syndrome with full and segmental trisomy 21 begins in childhood as revealed by immunoglobulin G glycosylation (2021) (1)
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- Abstract 1229: Clonal hematopoiesis of indeterminate potential (CHIP), centenarians and age-related cardiovascular risk: Is TET2 the culprit (2018) (1)
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- On the Way to Longevity: How to Combat Neuro-Degenerative Disease (2013) (1)
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- MATURATION OF THE IMMUNE RESPONSE IN VITRO (1972) (1)
- Mitochondrial DNA and aging: Study on heteroplasmy levels with DHPLC technology within the EU project MARKAGE (2013) (1)
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- UNDULATIONS OF THE PLASMA PROTEOME DEFINE DISTINCT STAGES OF HUMAN LIFESPAN AND REVEAL ACCELERATED AGING IN ALZHEIMER’S DISEASE (2019) (0)
- Erythropoietin (EPO) haplotype associated with all-cause mortality in a cohort of Italian patients with Type-2 Diabetes (2019) (0)
- Frailty in Old Age Is Associated with Altered Cytokine Production in Response to TLR Ligation (2019) (0)
- ProteaMAlg: a Proteasome Modelling Algorithm to address the complexity of intracellular protein degradation kinetics (2008) (0)
- Impact Of Physical Activity On N-glycan Profile In Older Adults (2019) (0)
- Heterogeneity of Cellular Senescence: Cell Type-Specific and Senescence Stimulus-Dependent Epigenetic Alterations (2023) (0)
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- Myotendinous and neuromuscular adaptation to long-term spaceflight: Results from the sarcolab pilot study (2016) (0)
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- Quantification of Mediator Relevance in Immune Cell Network (2007) (0)
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- Human Longevity Aging of the Immune System as a Prognostic Factor for (2016) (0)
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- Gene expression profiling in T cells with ageing: 2. analysis of time series results encompassing the whole human lifespan (2006) (0)
- Analysis of mitochondrial DNA sequence variations in type 2 diabetes patients characterized for haplogroup affiliation (2010) (0)
- SUN-P108: Effects of a 2-Month Dietand Nutraceutical Intervention on Quality of Life and Depression with Respect to Inflammaging: Ristomed, an Open Label Intervention Trial (2016) (0)
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- Survival features of EBV-stabilized cells from centenarians: morpho-functional and transcriptomic analyses (2011) (0)
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- Author Correction: Erythropoietin (EPO) haplotype associated with all-cause mortality in a cohort of Italian patients with Type-2 Diabetes (2020) (0)
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- Contributors to immune senescence during treated HIV-1 infection (2017) (0)
- Conserved and species-specific molecular denominators in mammalian skeletal muscle aging (2017) (0)
- Review Mitochondrial DNA involvement in human longevity (2006) (0)
- 3-Aminobenzamide protection from apoptosis: The role of cytoskeleton (1995) (0)
- Mitochondrial haplogroups in a Sardinian centenarian population. (2006) (0)
- Analysis of mitochndrial membrane potential [delta psi] with fluorescent probes (1997) (0)
- LONGEVITY AND MYOCARDIAL INFARCTION: ROLE OF ALPHA1-ANTITRYPSIN DEFICENCY (2004) (0)
- Gene expression profiling of Healthy Centenarians (2001) (0)
- Mitochondria, Aging, and Disease: A Genomic Perspective (2003) (0)
- Author response: Whole-genome sequencing analysis of semi-supercentenarians (2021) (0)
- [Chronic persistent HBsAG positive hepatitis in children. I. Subpopulations of T and B lymphocytes]. (1978) (0)
- Home administration of Pamidronate in patients with bone metastases from various types of cancers. Using an intermate infusion device. (2000) (0)
- Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains (2021) (0)
- Progetto Neurooncologia Emilia Romagna - PERNO (2008) (0)
- Brain aging and garbage cleaning (2020) (0)
- The epigenetic landscape of age-related diseases: the geroscience perspective (2017) (0)
- Towards an unifying perspective of the fundamental properties and structural principles governing the immune system (2008) (0)
- Association between fat-soluble vitamins and self-reported health status: a cross-sectional analysis of the MARK-AGE cohort (2021) (0)
- MicroRNA profiles of human peripheral arteries and abdominal aorta in normal conditions: MicroRNAs-27a-5p, -139-5p and -155-5p emerge and in atheroma too (2021) (0)
- Sarcolab pilot study into skeletal muscle’s adaptation to long-term spaceflight (2018) (0)
- A novel action for adenosine suggested by apoptosis of astroglial cells in rat brain primary cultures (1995) (0)
- Author Correction: Sarcolab pilot study into skeletal muscle’s adaptation to longterm spaceflight (2018) (0)
- K252a, a high affinity NGF-receptor (trk) inhibitor, induces apoptosis in cultured human keratinocytes. (1995) (0)
- Differential expression of perilipin 2 and 5 in human skeletal muscle during aging and their association with atrophy-related genes (2015) (0)
- Association of Torquetenovirus viremia with physical frailty and cognitive impairment in three independent European cohorts. (2022) (0)
- Epigenomic signature of the progeroid Cockayne syndrome exposes distinct and common features with physiological ageing (2021) (0)
- Compared effects of N-hydroxyurethan, urethan and hydroxyurea on DNA synthesis. In vivo and in vitro studies (1977) (0)
- Erratum to: Differential expression of perilipin 2 and 5 in human skeletal muscle during aging and their association with atrophy-related genes (2015) (0)
- HUMAN LYMPHOC'flE PROLIFERATIIN VITRO AND DNA REPAIR (1988) (0)
- A General Learning Rule for Network Modeling of Neuroimmune Interactome (2005) (0)
- Down Syndrome: Neuropsychological phenotype and mitochondrial DNA (2012) (0)
- Self‑rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains Konstanzer Online-Publikations-System (KOPS) URL: (2021) (0)
- Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer’s disease in comparison with healthy aging (2020) (0)
- Small immunological clocks identified by Deep Learning and Gradient Boosting (2023) (0)
- The smell of longevity: a combination of Volatile Organic Compounds (VOCs) can discriminate centenarians and their offspring from age-matched subjects and young controls (2019) (0)
- Heterogeneity of prodromal Parkinson symptoms in siblings of Parkinson disease patients (2021) (0)
- Disease classification for whole-blood DNA methylation: Meta-analysis, missing values imputation, and XAI (2022) (0)
- Role of Non-feminizing Estrogens in Brain Protection from Cerebral Ischemia and Alzheimer ’ s Disease Neuropathology (2016) (0)
- Remodelling of biological parameters during human ageing: evidence for complex regulation in longevity and in type 2 diabetes (2011) (0)
- Distinct profile of CD34+ cells and plasma-derived extracellular vesicles from triple-negative patients with Myelofibrosis reveals potential markers of aggressive disease (2021) (0)
- Cognitive and Functional Old Subjects with Impaired Health and Very Response to Human Cytomegalovirus in Intense Antiextracellular Adaptive Immune (2010) (0)
- DNA repair after gamma radiation and high temperature in peripheral blood lymphocytes from MS patients (1987) (0)
- P1-339 mtDNA inherited and somatic variability in Alzheimer’s disease (2006) (0)
- NACHR4 594C/T SNP IN ALZHEIMER’S DISEASE (2005) (0)
- Gender-differences in centenarians: Health status and life-style (2013) (0)
- Naïve and memory CD8 T cell pool homeostasis in advanced aging: impact of age and of antigen-specific responses to cytomegalovirus (2013) (0)
- Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity. (2023) (0)
- MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling (2012) (0)
- Identification of a T cell gene expression clock obtained by exploiting a MZ twin design (2017) (0)
- Metabolite and lipoprotein profiles reveal sex-related oxidative stress imbalance in de novo drug-naive Parkinson’s disease patients (2022) (0)
- Role of IGF1 system in human longevity. A study in a wide population of centenarians and centenarians' offspring (2010) (0)
- Genomic stability, anti-inflammatory phenotype, and up-regulation of the RNAseH2 in cells from centenarians (2019) (0)
- Epigenetic clocks suggest accelerated aging in patients with isolated REM Sleep Behavior Disorder (2023) (0)
- The Malignant Hemopoietic Clone of Triple Negative Patients with Myelofibrosis Shows in Vitro Functional Defects but Is Highly Responsive to the Pro-Survival Signals of Circulating Autologous Microvesicles (2018) (0)
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- Regulatory T cells from patients with end-stage organ disease can be isolated, expanded and cryopreserved according good manufacturing practice improving their function (2019) (0)
- Forthcoming papers Effect of hyperthermia on the internal microviscosity of erythrocytes and lymph- ocytes : a spin label study (1990) (0)
- Deep Learning vs Gradient Boosting in age prediction on immunology profile (2022) (0)
- Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians’ offspring (2012) (0)
- Levamisole and HBsAg positive chronic persistent hepatitis. (1978) (0)
- Author response: Non-nucleoside reverse transcriptase inhibitor-based combination antiretroviral therapy is associated with lower cell-associated HIV RNA and DNA levels compared to protease inhibitor-based therapy (2021) (0)
- DNA methylation in human teeth as a molecular mechanism for age-estimation: a preliminary study focused on the cementum, dentin and pulp of teeth from modern individuals (2016) (0)
- Age-dependent alteration in muscle regeneration: the critical role of tissue niche (2013) (0)
- Transcriptomic analysis reveals an association of FCGBP with Parkinson’s disease (2022) (0)
- Population-specific association of genes for telomere-associated proteins with longevity in an Italian population (2015) (0)
- Serum dehydroepiandrosterone sulfate (DHEA-S) and total antioxidant capacity (TAC) in healthy centenarian subjects. (1999) (0)
- The expression pattern of GDF15 in human brain changes during aging and in Alzheimer’s disease (2023) (0)
- Uncovering the Relationship between Selenium Status, Age, Health, and Dietary Habits: Insights from a Large Population Study including Nonagenarian Offspring from the MARK-AGE Project (2023) (0)
- One-year Mediterranean diet promotes epigenetic rejuvenation with country- and sex-specific effects: a pilot study from the NU-AGE project (2020) (0)
- Circulating miR-122-5p, miR-92a-3p, and miR-18a-5p as Potential Biomarkers in Human Liver Transplantation Follow-Up (2023) (0)
- A public health perspective of aging: do hyper-inflammatory syndromes such as COVID-19, SARS, ARDS, cytokine storm syndrome, and post-ICU syndrome accelerate short- and long-term inflammaging? (2020) (0)
- Long-term human spaceflight and inflammaging: Does it promote aging? (2023) (0)
- Genomic stability, anti-inflammatory phenotype and up-regulation of the RNAseH2-dependent RNA:DNA hybrid degrading enzyme in cells from centenarians. (2019) (0)
- Evidence for the presence of immunoreactive POMC-derived peptides and cytokines in the thymus of the goldfish (Carassius c. auratus) (2004) (0)
- Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years (2017) (0)
- Electrocardiographic Evaluation of Pregnant Women with Indeterminate Chagas Disease (2010) (0)
- Paper alert. (2020) (0)
- The invertebrate blueprint of the connection between aging and immune neuroendocrine responses (2009) (0)
- DNAging: the forum for molecular biological research on aging (1989) (0)
- Adenosine-Induced Apoptosis of C 2 C 12 Myoblastic Cells (2007) (0)
- Tu-P10:405 Increased levels of cysteine and homocysteine in Sardinian centenarians (AKEA-project) (2006) (0)
- in Very Old Subjects T Cells against Cytomegalovirus + and CD8 + Massive Load of Functional Effector CD4 (2012) (0)
- Corrigendum to “Immune parameters identify Italian centenarians with a longer five-year survival independent of their health and functional status” [Exp. Gerontol. 54C (2014) 14–20] (2016) (0)
- -174 c>g polymorphism in interleukin-6 gene promoter affects preoperative interleukin-6 serum level in patients with colorectal cancer (2003) (0)
- Immunogenetics of longevity: HLA antigens in Italian Centenarians (2001) (0)
- Embedding machine-readable proteins interactions data in scientific articles for easy access and retrieval (2008) (0)
- Absence of the Prothrombin Gene Variant in Koreans (2012) (0)
- Preparation and Purification of Latrodectus Antivenene. (1942) (0)
- Perspectives: Is Immunosenescence Clinically Relevant? (2019) (0)
- Lifelong calorie restriction and markers of colonic health in aging mice (2018) (0)
- The influences on human longe v ity by HUMTHO 1 . STR polymorphism ( Tyrosine Hydroxylase gene ) A relati v e risk approach (2002) (0)
- Sysbiohealth Symposium 2007 (2007) (0)
- RECIPROCAL FUELLING OF GARBAGING/INFLAMMAGING AND CHRONIC AGE-RELATED DISEASES (2017) (0)
- Correction: Analysis of Population Substructure in Two Sympatric Populations of Gran Chaco, Argentina (2014) (0)
- L'inevitabile Retorica Del Discorso Scientifico (2005) (0)
- Sex differences in genetic associations with longevity in Han Chinese-- Sex-stratified GWAS and polygenic risk score analyses (2017) (0)
- K252a, A High-Affinity NGF-Receptor (Trk) Inhibitor, Induces Apoptosis In Human Keratinocytes (1995) (0)
- The Properties of Anti-Anthrax Serum: the Protective Antibodies. (0)
- Interleukin-10 (IL-10) genotype frequencies in Italian centenarians (2001) (0)
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What Schools Are Affiliated With Claudio Franceschi?
Claudio Franceschi is affiliated with the following schools: