Claudio A. Hetz

Claudio A. Hetz's AcademicInfluence.com Rankings

Claudio A. Hetz

Biology

#6764

World Rank

#9553

Historical Rank

Cell Biology

#233

World Rank

#241

Historical Rank

Neuroscience

#825

World Rank

#859

Historical Rank

Biochemistry

#891

World Rank

#999

Historical Rank

biology Degrees

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Biology

Claudio A. Hetz's Degrees

PhD Biochemistry University of Chile

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Claudio A. Hetz's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Guidelines for the use and interpretation of assays for monitoring autophagy (2012) (6925)
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018) (3106)
The unfolded protein response: controlling cell fate decisions under ER stress and beyond (2012) (2930)
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012) (2913)
The Unfolded Protein Response and Cell Fate Control. (2017) (844)
Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia. (2005) (811)
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 (2021) (811)
Targeting the unfolded protein response in disease (2013) (809)
In Vitro Generation of Infectious Scrapie Prions (2005) (778)
Mechanisms, regulation and functions of the unfolded protein response (2020) (686)
Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases (2014) (581)
Proteostasis control by the unfolded protein response (2015) (551)
ER stress and the unfolded protein response in neurodegeneration (2017) (549)
XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. (2009) (509)
The unfolded protein response: integrating stress signals through the stress sensor IRE1α. (2011) (499)
Proapoptotic BAX and BAK Modulate the Unfolded Protein Response by a Direct Interaction with IRE1α (2006) (473)
Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease. (2018) (420)
Caspase‐12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein (2003) (408)
Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome. (2009) (397)
When ER stress reaches a dead end. (2013) (375)
Endoplasmic Reticulum Stress and the Hallmarks of Cancer. (2016) (335)
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018) (323)
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. (2009) (290)
Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons (2013) (289)
Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis. (2015) (269)
Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 1. An overview. (2014) (257)
Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy. (2012) (250)
Modulating stress responses by the UPRosome: a matter of life and death. (2011) (241)
HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1α-XBP1 Signaling through a Physical Interaction (2010) (240)
Protein folding stress in neurodegenerative diseases: a glimpse into the ER. (2011) (228)
Axonal Degeneration Is Mediated by the Mitochondrial Permeability Transition Pore (2011) (201)
The Disulfide Isomerase Grp58 Is a Protective Factor against Prion Neurotoxicity (2005) (199)
Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1 (2014) (182)
An ERcentric view of Parkinson's disease. (2013) (175)
Calcium signaling at the endoplasmic reticulum: fine-tuning stress responses. (2017) (167)
Emerging roles of ER stress in the etiology and pathogenesis of Alzheimer's disease (2018) (163)
BCL-2 family: integrating stress responses at the ER to control cell demise (2017) (162)
Pharmacological targeting of the unfolded protein response for disease intervention (2019) (160)
Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis (2008) (158)
Integrating stress signals at the endoplasmic reticulum: The BCL-2 protein family rheostat. (2011) (155)
Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases (2021) (149)
Endoplasmic reticulum proteostasis impairment in aging (2017) (144)
Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics (2019) (142)
Thy-1 binds to integrin β3 on astrocytes and triggers formation of focal contact sites (2001) (137)
The stress rheostat: an interplay between the unfolded protein response (UPR) and autophagy in neurodegeneration. (2008) (133)
IRE1 signaling exacerbates Alzheimer’s disease pathogenesis (2017) (130)
Microcin E492, a channel-forming bacteriocin from Klebsiella pneumoniae, induces apoptosis in some human cell lines (2002) (130)
Targeting autophagy in neurodegenerative diseases. (2014) (128)
Activation of the unfolded protein response enhances motor recovery after spinal cord injury (2012) (128)
Regulation of Memory Formation by the Transcription Factor XBP1. (2016) (127)
Dual IRE1 RNase functions dictate glioblastoma development (2018) (121)
Caspase-dependent initiation of apoptosis and necrosis by the Fas receptor in lymphoid cells: onset of necrosis is associated with delayed ceramide increase (2002) (119)
Converging pathways in the occurrence of endoplasmic reticulum (ER) stress in Huntington's disease. (2011) (118)
Amyloid β-peptide oligomers stimulate RyR-mediated Ca2+ release inducing mitochondrial fragmentation in hippocampal neurons and prevent RyR-mediated dendritic spine remodeling produced by BDNF. (2011) (116)
Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α. (2018) (113)
ER stress signaling and the BCL-2 family of proteins: from adaptation to irreversible cellular damage. (2007) (110)
BH3‐only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α (2012) (107)
The unfolded protein response in Alzheimer’s disease (2013) (105)
Targeting PERK signaling with the small molecule GSK2606414 prevents neurodegeneration in a model of Parkinson's disease (2018) (104)
TMBIM protein family: ancestral regulators of cell death (2014) (103)
Endoplasmic reticulum proteostasis in glioblastoma—From molecular mechanisms to therapeutic perspectives (2017) (100)
Stressing out the ER: a role of the unfolded protein response in prion-related disorders. (2006) (97)
Protein disulfide isomerases in neurodegeneration: From disease mechanisms to biomedical applications (2012) (96)
Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis (2014) (95)
Measurement of autophagy flux in the nervous system in vivo (2013) (94)
ER Dysfunction and Protein Folding Stress in ALS (2013) (93)
Interplay Between the Oxidoreductase PDIA6 and microRNA-322 Controls the Response to Disrupted Endoplasmic Reticulum Calcium Homeostasis (2014) (92)
A failure in energy metabolism and antioxidant uptake precede symptoms of Huntington’s disease in mice (2013) (92)
Autophagy in hepatic adaptation to stress. (2020) (91)
The daily job of night killers: alternative roles of the BCL-2 family in organelle physiology. (2008) (90)
BAX inhibitor‐1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response (2011) (89)
Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis (2012) (89)
ALS‐linked protein disulfide isomerase variants cause motor dysfunction (2016) (87)
Commentary: XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity (2016) (87)
Prion Protein Misfolding Affects Calcium Homeostasis and Sensitizes Cells to Endoplasmic Reticulum Stress (2010) (82)
Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia. (2012) (80)
IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A (2018) (78)
TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis (2012) (78)
Functional Contribution of the Transcription Factor ATF4 to the Pathogenesis of Amyotrophic Lateral Sclerosis (2013) (77)
Is loss of function of the prion protein the cause of prion disorders? (2003) (74)
Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury (2016) (74)
Perturbation of Endoplasmic Reticulum Homeostasis Facilitates Prion Replication* (2007) (73)
The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivo (2017) (73)
The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosis (2007) (73)
AAV-mediated delivery of the transcription factor XBP1s into the striatum reduces mutant Huntingtin aggregation in a mouse model of Huntington's disease. (2012) (71)
Mystery solved: Trehalose kickstarts autophagy by blocking glucose transport (2016) (70)
Gene expression-based discovery of atovaquone as a STAT3 inhibitor and anticancer agent. (2016) (70)
Amyotrophic lateral sclerosis pathogenesis: a journey through the secretory pathway. (2010) (69)
ER Proteostasis Control of Neuronal Physiology and Synaptic Function (2018) (69)
Nonselective cation channels as effectors of free radical–induced rat liver cell necrosis (2001) (67)
Addicted to secrete - novel concepts and targets in cancer therapy. (2014) (67)
Beyond apoptosis: nonapoptotic cell death in physiology and disease. (2005) (66)
The UFMylation System in Proteostasis and Beyond. (2019) (66)
Identification of rare protein disulfide isomerase gene variants in amyotrophic lateral sclerosis patients. (2015) (66)
Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis (2018) (64)
Targeting the unfolded protein response for disease intervention (2015) (61)
Bax Channel Inhibitors Prevent Mitochondrion-mediated Apoptosis and Protect Neurons in a Model of Global Brain Ischemia* (2005) (59)
Hormesis: protecting neurons against cellular stress in Parkinson disease. (2012) (58)
Oxidative stress activates the c-Abl/p73 proapoptotic pathway in Niemann-Pick type C neurons (2011) (57)
Glucose Metabolism: A Sweet Relief of Alzheimer’s Disease (2016) (53)
Astrocytic αVβ3 Integrin Inhibits Neurite Outgrowth and Promotes Retraction of Neuronal Processes by Clustering Thy-1 (2012) (53)
The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity (2014) (52)
Small Molecules to Improve ER Proteostasis in Disease. (2019) (52)
Prion replication alters the distribution of synaptophysin and caveolin 1 in neuronal lipid rafts. (2004) (52)
Crosstalk between the UPR and autophagy pathway contributes to handling cellular stress in neurodegenerative disease (2012) (52)
Role of the unfolded protein response in organ physiology: Lessons from mouse models (2013) (51)
The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein* (2015) (50)
Emerging Roles of the Endoplasmic Reticulum Associated Unfolded Protein Response in Cancer Cell Migration and Invasion (2019) (49)
The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease (2019) (49)
Hormesis (2012) (47)
Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response (2020) (47)
Molecular mechanisms of neurotoxicity of pathological prion protein. (2004) (47)
Protein misfolding and disease: the case of prion disorders (2003) (47)
Prion Pathogenesis is Independent of Caspase-12 (2007) (46)
Genome-wide circulating microRNA expression profiling reveals potential biomarkers for amyotrophic lateral sclerosis (2017) (43)
The intersection between growth factors, autophagy and ER stress: A new target to treat neurodegenerative diseases? (2016) (43)
XBP-1 deficiency in the nervous system reveals a homeostatic switch to activate autophagy (2009) (42)
Brain organoids: a next step for humanized Alzheimer’s disease models? (2019) (42)
When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response. (2020) (40)
Memory loss in Alzheimer's disease: are the alterations in the UPR network involved in the cognitive impairment? (2014) (40)
ER proteostasis addiction in cancer biology: Novel concepts. (2015) (40)
Abnormal calcium homeostasis and protein folding stress at the ER (2011) (38)
Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration (2015) (37)
Autophagosomes cooperate in the degradation of intracellular C‐terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway (2017) (36)
Altered Prion Protein Expression Pattern in CSF as a Biomarker for Creutzfeldt-Jakob Disease (2012) (36)
Adaptive preconditioning in neurological diseases – therapeutic insights from proteostatic perturbations (2016) (36)
NFκB is a central regulator of protein quality control in response to protein aggregation stresses via autophagy modulation (2016) (36)
Adapting the proteostasis capacity to sustain brain healthspan (2021) (36)
A BAX/BAK and Cyclophilin D-Independent Intrinsic Apoptosis Pathway (2012) (35)
The Unfolded Protein Response: At the Intersection between Endoplasmic Reticulum Function and Mitochondrial Bioenergetics (2017) (35)
Targeting autophagy in ALS: A complex mission (2011) (35)
Control of systemic proteostasis by the nervous system. (2015) (35)
BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE 1 a (2009) (34)
Protein homeostasis networks in physiology and disease. (2011) (34)
Gene therapy to target ER stress in brain diseases (2016) (34)
PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response (2015) (34)
Diminishing Apoptosis by Deletion of Bax or Overexpression of Bcl-2 Does Not Protect against Infectious Prion Toxicity In Vivo (2007) (33)
The ER proteostasis network in ALS: Determining the differential motoneuron vulnerability (2017) (33)
Insulin-like growth factor 2 (IGF2) protects against Huntington’s disease through the extracellular disposal of protein aggregates (2020) (33)
Targeting of the unfolded protein response (UPR) as therapy for Parkinson's disease (2019) (33)
Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 (2016) (33)
Editorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652 (2016) (31)
ER Stress and Neurodegenerative Disease: A Cause or Effect Relationship? (2018) (31)
BAX inhibitor‐1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response (2017) (31)
A novel ER stress-independent function of the UPR in angiogenesis. (2014) (31)
Gene Therapy Strategies to Restore ER Proteostasis in Disease. (2018) (30)
Herp depletion protects from protein aggregation by up-regulating autophagy. (2013) (30)
Autophagy impairment: a crossroad between neurodegeneration and tauopathies (2012) (30)
ER proteostasis disturbances in Parkinson's disease: novel insights (2015) (29)
Interplay Between the Unfolded Protein Response and Immune Function in the Development of Neurodegenerative Diseases (2018) (29)
Proteostasis disturbance in amyotrophic lateral sclerosis (2017) (29)
Unspliced XBP1 controls autophagy through FoxO1 (2013) (29)
Bax Inhibitor-1-mediated Ca2+ leak is decreased by cytosolic acidosis. (2013) (28)
ER stress signaling and neurodegeneration: At the intersection between Alzheimer's disease and Prion-related disorders. (2015) (28)
Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease (2020) (27)
The biological meaning of the UPR (2013) (26)
The UPRosome – decoding novel biological outputs of IRE1α function (2020) (26)
A new method to measure autophagy flux in the nervous system (2014) (24)
Common ground: stem cell approaches find shared pathways underlying ALS. (2014) (23)
Injury to the nervous system: A look into the ER (2016) (21)
Mastering organismal aging through the endoplasmic reticulum proteostasis network (2020) (19)
Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis (2019) (18)
The UPR as a survival factor of cancer cells: More than folding proteins? (2009) (18)
BCL-2 protein family : essential regulators of cell death (2010) (17)
Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration. (2021) (17)
Turning off the unfolded protein response: An interplay between the apoptosis machinery and ER stress signaling (2009) (17)
Endoplasmic Reticulum stress signaling and the pathogenesis of Non-Alcoholic Fatty Liver Disease (2019) (16)
Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43A315T ALS/FTD mouse model (2017) (16)
BCL-2 protein family. Essential regulators of cell death. Preface. (2010) (15)
Autophagy meets fused in sarcoma-positive stress granules (2014) (15)
The ER in 4D: a novel stress pathway controlling endoplasmic reticulum membrane remodeling (2012) (15)
Acute Pannexin 1 Blockade Mitigates Early Synaptic Plasticity Defects in a Mouse Model of Alzheimer’s Disease (2020) (15)
Fine-tuning PERK signaling to control cell fate under stress (2017) (14)
Cyclosporine A binding to COX-2 reveals a novel signaling pathway that activates the IRE1α unfolded protein response sensor (2018) (14)
Caveolin-1 suppresses tumor formation through the inhibition of the unfolded protein response (2020) (13)
Drug repurposing to target proteostasis and prevent neurodegeneration: accelerating translational efforts. (2017) (13)
Lack of Activation of the Unfolded Protein Response in Mouse and Cellular Models of Niemann-Pick Type C Disease (2010) (13)
Emerging roles of the unfolded protein response signaling in physiology and disease. (2006) (13)
Unraveling the role of motoneuron autophagy in ALS (2018) (12)
Emerging roles of the unfolded protein response (UPR) in the nervous system: A link with adaptive behavior to environmental stress? (2020) (12)
BH 3-only proteins are part of a regulatory network that control the sustained signaling of the Unfolded Protein Response sensor IRE 1 α (2010) (12)
Fine-Tuning ER Stress Signal Transducers to Treat Amyotrophic Lateral Sclerosis (2017) (12)
Erratum: Proteostasis control by the unfolded protein response (2015) (11)
The unfolded protein response in alzheimers disease (2013) (11)
Alternative functions of the BCL-2 protein family at the endoplasmic reticulum. (2010) (11)
ER stress sensing mechanism: Putting off the brake on UPR transducers (2018) (11)
A Molecular Reporter for Monitoring Autophagic Flux in Nervous System In Vivo. (2017) (11)
Control of mammalian brain aging by the unfolded protein response (UPR) (2020) (11)
β-catenin aggregation in models of ALS motor neurons: GSK3β inhibition effect and neuronal differentiation (2019) (10)
ERp57 in neurodegeneration and regeneration (2016) (10)
The p75NTR neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability (2019) (10)
A decay of the adaptive capacity of the unfolded protein response exacerbates Alzheimer's disease (2017) (10)
BAX inhibitor‐1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response (2021) (9)
Protein disulfide isomerase ERp57 protects early muscle denervation in experimental ALS (2021) (9)
Gene therapy in Parkinson's disease: targeting the endplasmic reticulum proteostasis network (2015) (9)
Balancing energy and protein homeostasis at ER-mitochondria contact sites (2022) (9)
Protein Misfolding Disorders: A Trip into the ER (2018) (8)
Correction: Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration (2015) (8)
Cell-nonautonomous control of the UPR: mastering energy homeostasis. (2014) (8)
Peroxisomes Get Loud: A Redox Antidote to Hearing Loss (2015) (8)
Proteostasis impairment: at the intersection between Alzheimer's disease and diabetes. (2013) (8)
Homeostatic interplay between FoxO proteins and ER proteostasis in cancer and other diseases. (2018) (8)
BCL-2 Protein Family (2010) (8)
ERp57 as a novel cellular factor controlling prion protein biosynthesis: Therapeutic potential of protein disulfide isomerases (2016) (8)
ER stress in neurodegenerative disease: from disease mechanisms to therapeutic interventions (2017) (8)
(off)Targeting UPR signaling: the race toward intervening ER proteostasis (2018) (7)
A new model to study cell-to-cell transfer of αSynuclein in vivo. (2018) (7)
Cell death regulation by MAMs: from molecular mechanisms to therapeutic implications in cardiovascular diseases (2022) (7)
RESETing ER proteostasis: selective stress pathway hidden in the secretory route (2014) (7)
Control of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1 (2021) (7)
Publisher Correction: Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics (2019) (6)
Apoptosis, necrosis and autophagy: from mechanisms to biomedical applications. (2008) (6)
Targeting endoplasmic reticulum acetylation to restore proteostasis in Alzheimer's disease. (2016) (6)
ER stress links aging to sporadic ALS (2019) (6)
Theme Series--UPR in cancer. (2015) (6)
A phenolic-rich extract from Ugni molinae berries reduces abnormal protein aggregation in a cellular model of Huntington’s disease (2021) (6)
Critical roles of protein disulfide isomerases in balancing proteostasis in the nervous system (2022) (5)
Editorial [ Apoptosis, Necrosis and Autophagy: From Mechanisms to Biomedical Applications (Part-I) Guest Editor: Claudio Hetz ] (2008) (5)
Retinal Ganglion Cells Functional Changes in a Mouse Model of Alzheimer's Disease Are Linked with Neurotransmitter Alterations. (2021) (5)
Saved by the Matrix: UPR Independent Survival under ER Stress (2019) (5)
Cell‐nonautonomous control of the UPR (2012) (4)
DEF8 and Autophagy-Associated Genes are Altered in Mild Cognitive Impairment, Probable Alzheimer's Disease Patients and a Transgenic Model of the Disease. (2021) (4)
RNA metabolism: putting the brake on the UPR (2015) (4)
Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging (2022) (3)
Stress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputs (2020) (3)
BH3‐only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α (2021) (3)
Simultaneous determination of intraluminal lysosomal calcium and pH by dextran-conjugated fluorescent dyes. (2021) (3)
Mutation in protein disulfide isomerase A3 causes neurodevelopmental defects by disturbing endoplasmic reticulum proteostasis (2021) (3)
Stressing out the ER in aminoglycoside-induced hearing loss (2015) (3)
Protein homeostasis: Modeling UPR adaptive responses. (2014) (3)
Publisher Correction: Pharmacological targeting of the unfolded protein response for disease intervention (2019) (3)
Proteostasis and resilience: on the interphase between individual’s and intracellular stress (2022) (3)
Dual Role of Autophagy in Neurodegenerative Diseases: The Case of Amyotrophic Lateral Sclerosis (2015) (2)
Prion Function and Pathophysiology in Non-Mammalian Models. (2017) (2)
Bursting the unfolded protein response accelerates axonal regeneration (2016) (2)
Correction: The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease (2020) (2)
Paradoxical implication of BAX/BAK in the persistence of tetraploid cells (2021) (2)
Prion Protein Misfolding and Brain Degeneration (2003) (2)
Signaling Pathways Controling Prion Neurotoxicity: Role of Endoplasmic Reticulum Stress-Mediated Apoptosis (2005) (2)
Targeting Endoplasmic Reticulum Stress Pathways to Treat Neurological Disorders Associated with Protein Misfolding (2009) (2)
P125Endoplasmic reticulum stress responses to disrupted endoplasmic reticulum ca2+ homeostasis (2014) (2)
IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A (2018) (2)
Disruption of Endoplasmic Reticulum Proteostasis in Age-Related Nervous System Disorders. (2021) (2)
Proapoptotic RECS1: a requisite gateway to lysosomal dysfunction and death (2022) (2)
Erratum: Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis (Proceedings of the National Academy of Sciences of the United States of America (2008) 105:2 (757-762) DOI: 10.1073/pnas.0711094105) (2009) (2)
Therapeutic potential of insulin-like growth factor 2 in Huntington’s disease: controlling proteostasis to alleviate the load of misfolded protein (2021) (1)
Editorial: signaling in cell death, survival, proliferation and degeneration. (2013) (1)
Proteostasis deregulation as a driver of C9ORF72 pathogenesis (2021) (1)
The unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease by improving synaptic function and proteostasis (2022) (1)
Getting intimate: Lysosomes and ER rendezvous to control autophagy. (2020) (1)
Caspase‐12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein (2021) (1)
Protein disulfide isomerase gene variants are associated with amyotrophic lateral sclerosis (2014) (1)
Correction: Prion Protein Misfolding Affects Calcium Homeostasis and Sensitizes Cells to Endoplasmic Reticulum Stress (2011) (1)
Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the unfolded protein response (UPR) in models of neurodegeneration (2020) (1)
Neuronal Rubicon Represses Extracellular APP/Amyloid β Deposition in Alzheimer’s Disease (2022) (1)
A chosen STING with a PERKy trail (2022) (1)
Mitochondria-associated niches in health and disease. (2022) (1)
Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease (2020) (0)
Editorial [Hot Topic: Emerging Roles of the Unfolded Protein Response Signaling in Physiology and Disease (Executive Editor: Claudio A. Hetz and Claudio Soto )] (2006) (0)
Assays to Study IRE1 Activation and Signaling. (2022) (0)
Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43A315T ALS/FTD mouse model (2017) (0)
Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics (2019) (0)
Publisher Correction: IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A (2018) (0)
The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity (2014) (0)
Erratum (2000) (0)
Calcium signaling in lysosome-dependent cell death (2023) (0)
Protein disulfide isomerase ERp57 protects early muscle denervation in experimental ALS (2021) (0)
Publisher Correction: IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A (2018) (0)
Insulin-like growth factor 2 (IGF2) protects against HD through the extracellular disposal of protein aggregates (2019) (0)
Mechanisms, regulation and functions of the unfolded protein response (2020) (0)
Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response (2020) (0)
The p75NTR neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability (2019) (0)
PREFACE: Divergent roles of ER stress in neurodegeneration and brain disorders (2016) (0)
Expression of Concern: Caspase-dependent initiation of apoptosis and necrosis by the Fas receptor in lymphoid cells: onset of necrosis is associated with delayed ceramide increase. (2022) (0)
DiminishingApoptosisbyDeletionofBaxorOverexpressionof Bcl-2DoesNotProtectagainstInfectiousPrionToxicityInVivo (2007) (0)
Cyclosporine A binding to COX-2 reveals a novel signaling pathway that activates the IRE1α unfolded protein response sensor (2018) (0)
Royal academy of medicine in Ireland (0)
The endoplasmic reticulum stress sensor IRE1 regulates collagen secretion through the enforcement of the proteostasis factor P4HB/PDIA1 contributing to liver damage and fibrosis (2023) (0)
Emerging roles of endoplasmic reticulum proteostasis in brain development. (2022) (0)
[Creutzfeldt-Jakob disease: Report of one case]. (2016) (0)
Publisher Correction: Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics (2019) (0)
Autophagy impairment: a crossroad between neurodegeneration and tauopathies (2012) (0)
Dual IRE1 RNase functions dictate glioblastoma development (2022) (0)
Corrigendum (2021) (0)
The unfolded protein response in Alzheimer’s disease (2013) (0)
Meet Our Associate Editor (2015) (0)
Erratum: Barrientos et al., “Axonal Degeneration Is Mediated by the Mitochondrial Permeability Transition Pore” (2021) (0)
Author Correction: IRE1α governs cytoskeleton remodeling and cell migration through a direct interaction with filamin A (2021) (0)
Correction for Hetz et al., Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis (2009) (0)
Editorial (Hot Topic: Signaling in Cell Death, Survival, Proliferation and Degeneration) (2012) (0)
Decision letter: Cell-based HTS identifies a chemical chaperone for preventing ER protein aggregation and proteotoxicity (2019) (0)
Proteostasis impairment and ER stress as a possible target to treat Parkinson's disease (2021) (0)
Apoptotic cell death in disease—Current understanding of the NCCD 2023 (2023) (0)
Dual IRE1 RNase functions dictate glioblastoma development (2023) (0)
Author Correction: IRE1α governs cytoskeleton remodeling and cell migration through a direct interaction with filamin A (2021) (0)
Transition Metals in Atmospheric Particulate Matter of Santiago and Concepcion Cities in Chile are Correlated with Elevated Levels of LDH and Protein in Bronchoalveolar Lavages of Instilled Rats (2010) (0)
Correction: Prion Protein Misfolding Affects Calcium Homeostasis and Sensitizes Cells to Endoplasmic Reticulum Stress (2022) (0)
Correction: The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease (2020) (0)
amyotrophic lateral sclerosis by increasing autophagy XBP-1 deficiency in the nervous system protects against Material Supplemental (2009) (0)
Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis (2019) (0)
Control of mammalian brain ageing by the unfolded protein response transcription factor XBP1 (2020) (0)
When the Good Turns Bad: Challenges in the Targeting of Autophagy in Neurodegenerative Diseases (2015) (0)
Abstracts of the Royal Academy of Medicine in Ireland Section of Biomedical Sciences Annual Meeting 2012. June 14, 2012. Galway, Ireland. (2013) (0)
Supplementary Material for: Lack of Activation of the Unfolded Protein Response in Mouse and Cellular Models of Niemann-Pick Type C Disease (2017) (0)
Author Correction: Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury (2021) (0)
Regulation of Memory For mation by the Transcription Factor XBP 1 Graphical (2016) (0)

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Claudio A. Hetz is affiliated with the following schools:

University of Chile
Osaka University
Brandeis University

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What Schools Are Affiliated With Claudio A. Hetz?

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