Clifton Bogardus
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Engineering Computer Science
Clifton Bogardus's Degrees
- PhD Computer Science Stanford University
- Masters Electrical Engineering University of California, Berkeley
- Bachelors Computer Engineering University of California, Berkeley
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(Suggest an Edit or Addition)Clifton Bogardus's Published Works
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Published Works
- The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. (1999) (1869)
- Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. (1993) (1558)
- Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus (2000) (1464)
- Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action (1997) (1198)
- Reduced rate of energy expenditure as a risk factor for body-weight gain. (1988) (1191)
- Determinants of 24-hour energy expenditure in man. Methods and results using a respiratory chamber. (1986) (1093)
- Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans. (2011) (986)
- Skeletal muscle capillary density and fiber type are possible determinants of in vivo insulin resistance in man. (1987) (820)
- Skeletal muscle metabolism is a major determinant of resting energy expenditure. (1990) (804)
- Low ratio of fat to carbohydrate oxidation as predictor of weight gain: study of 24-h RQ. (1990) (741)
- Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts Type II diabetes independent of insulin resistance (2000) (737)
- High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes. (2002) (714)
- Impaired glucose tolerance as a disorder of insulin action. Longitudinal and cross-sectional studies in Pima Indians. (1988) (643)
- Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion. (2001) (641)
- Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergic-receptor gene. (1995) (640)
- Relationship of genetics, age, and physical fitness to daily energy expenditure and fuel utilization. (1989) (587)
- Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans. (2002) (567)
- High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes. (2002) (524)
- Evaluation of simple indices of insulin sensitivity and insulin secretion for use in epidemiologic studies. (2000) (473)
- Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects. (1984) (441)
- Relationship between degree of obesity and in vivo insulin action in man. (1985) (396)
- An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance. (1995) (380)
- Correlation between muscle glycogen synthase activity and in vivo insulin action in man. (1984) (361)
- Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development. (2001) (358)
- Identification of individuals with insulin resistance using routine clinical measurements. (2005) (353)
- Insulin resistance associated with lower rates of weight gain in Pima Indians. (1991) (332)
- Obesity in the Pima Indians: its magnitude and relationship with diabetes. (1991) (318)
- Skeletal muscle membrane lipid composition is related to adiposity and insulin action. (1995) (317)
- A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM (1995) (317)
- In Vivo Insulin Action Is Familial Characteristic in Nondiabetic Pima Indians (1987) (317)
- A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance. (2000) (301)
- Effects of Physical Training and Diet Therapy on Carbohydrate Metabolism in Patients with Glucose Intolerance and Non-insulin-dependent Diabetes Mellitus (1984) (295)
- Metabolic characteristics of individuals with impaired fasting glucose and/or impaired glucose tolerance. (1999) (283)
- A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia. (2000) (275)
- Effect of muscle glycogen depletion on in vivo insulin action in man. (1983) (263)
- Relatively low plasma leptin concentrations precede weight gain in Pima Indians (1997) (262)
- Microarray profiling of isolated abdominal subcutaneous adipocytes from obese vs non-obese Pima Indians: increased expression of inflammation-related genes (2005) (237)
- Familial dependence of the resting metabolic rate. (1986) (232)
- An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians. (1998) (229)
- Low urinary chiro-inositol excretion in non-insulin-dependent diabetes mellitus. (1990) (222)
- Obesity and insulin resistance: lessons learned from the Pima Indians. (1988) (222)
- Autosomal genomic scan for loci linked to obesity and energy metabolism in Pima Indians. (1998) (196)
- Lower sedentary metabolic rate in women compared with men. (1992) (196)
- Absence of Mutations in the Human OB Gene in Obese/Diabetic Subjects (1996) (189)
- Body weight gain in free-living Pima Indians: effect of energy intake vs expenditure (2003) (188)
- Determinants of energy expenditure and fuel utilization in man: effects of body composition, age, sex, ethnicity and glucose tolerance in 916 subjects (1999) (184)
- A Polymorphism in the Human Intestinal Fatty Acid Binding Protein Alters Fatty Acid Transport across Caco-2 Cells (*) (1996) (178)
- Thermic effect of infused glucose and insulin in man. Decreased response with increased insulin resistance in obesity and noninsulin-dependent diabetes mellitus. (1983) (177)
- Energy balance and weight regulation: genetics versus environment (2000) (176)
- Spontaneous physical activity and obesity: cross-sectional and longitudinal studies in Pima Indians. (1992) (175)
- Cloning and Characterization of PDK4 on 7q21.3 Encoding a Fourth Pyruvate Dehydrogenase Kinase Isoenzyme in Human* (1996) (175)
- Relationship between insulin-mediated glucose disposal and lipid metabolism in man. (1985) (171)
- Deterioration in carbohydrate metabolism and lipoprotein changes induced by modern, high fat diet in Pima Indians and Caucasians. (1991) (168)
- Exaggerated early insulin release and insulin resistance in a diabetes-prone population: a metabolic comparison of Pima Indians and Caucasians. (1991) (165)
- Short-term energy balance: relationship with protein, carbohydrate, and fat balances. (1988) (162)
- A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians. (2003) (161)
- Linkage of Chromosomal Markers on 4q With a Putative Gene Determining Maximal Insulin Action in Pima Indians (1993) (153)
- Structure and sequence variation at the human leptin receptor gene in lean and obese Pima Indians. (1997) (153)
- Interstitial insulin concentrations determine glucose uptake rates but not insulin resistance in lean and obese men. (1994) (152)
- Association Analysis of Variation in/Near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B With Type 2 Diabetes and Related Quantitative Traits in Pima Indians (2009) (150)
- Genomewide search for genes influencing percent body fat in Pima Indians: suggestive linkage at chromosome 11q21-q22. Pima Diabetes Gene Group. (1997) (150)
- Energy metabolism in African Americans: potential risk factors for obesity. (1999) (149)
- Linkage between obesity and a marker near the tumor necrosis factor-alpha locus in Pima Indians. (1995) (148)
- Energy expenditure, fat oxidation, and body weight regulation: a study of metabolic adaptation to long-term weight change. (2000) (147)
- Reduced insulin secretion: an independent predictor of body weight gain. (1995) (145)
- Increased expression of inflammation-related genes in cultured preadipocytes/stromal vascular cells from obese compared with non-obese Pima Indians (2005) (143)
- Distribution of In Vivo Insulin Action in Pima Indians as Mixture of Three Normal Distributions (1989) (142)
- Relationship between obesity and maximal insulin-stimulated glucose uptake in vivo and in vitro in Pima Indians. (1984) (140)
- Interrelationships between muscle morphology, insulin action, and adiposity. (1996) (138)
- Skeletal muscle uncoupling protein 3 expression is a determinant of energy expenditure in Pima Indians. (1999) (138)
- Low acute insulin secretory responses in adult offspring of people with early onset type 2 diabetes. (2001) (131)
- A brief overview of human energy metabolism and its relationship to essential obesity. (1992) (127)
- Insulin resistance is associated with reduced fasting and insulin-stimulated glycogen synthase phosphatase activity in human skeletal muscle. (1990) (126)
- Glucose storage is a major determinant of in vivo "insulin resistance" in subjects with normal glucose tolerance. (1986) (126)
- Increased fat accumulation in liver may link insulin resistance with subcutaneous abdominal adipocyte enlargement, visceral adiposity, and hypoadiponectinemia in obese individuals. (2008) (125)
- Regulation of glycogen synthase and phosphorylase activities by glucose and insulin in human skeletal muscle. (1987) (122)
- 11β-Hydroxysteroid dehydrogenase Type 1: genetic polymorphisms are associated with Type 2 diabetes in Pima Indians independently of obesity and expression in adipocyte and muscle (2004) (120)
- A low sympathoadrenal activity is associated with body weight gain and development of central adiposity in Pima Indian men. (1997) (119)
- Familiality of physical and metabolic characteristics that predict the development of non-insulin-dependent diabetes mellitus in Pima Indians. (1997) (119)
- Microarray profiling of skeletal muscle tissues from equally obese, non-diabetic insulin-sensitive and insulin-resistant Pima Indians (2002) (118)
- Plasma adiponectin and endogenous glucose production in humans. (2003) (118)
- Insulin downregulates pyruvate dehydrogenase kinase (PDK) mRNA: potential mechanism contributing to increased lipid oxidation in insulin-resistant subjects. (1998) (115)
- Energy expenditure by doubly labeled water: validation in lean and obese subjects. (1991) (114)
- Increased Resting Metabolic Rates in Obese Subjects with Non-insulin-dependent Diabetes Mellitus and the Effect of Sulfonylurea Therapy (1986) (106)
- The 24-h carbohydrate oxidation rate in a human respiratory chamber predicts ad libitum food intake. (2007) (102)
- A functional variant in the peroxisome proliferator-activated receptor gamma2 promoter is associated with predictors of obesity and type 2 diabetes in Pima Indians. (2003) (101)
- A Search for Variants Associated With Young-Onset Type 2 Diabetes in American Indians in a 100K Genotyping Array (2007) (100)
- No accumulation of glucose in human skeletal muscle during euglycemic hyperinsulinemia. (1988) (96)
- Metabolic factors contributing to increased resting metabolic rate and decreased insulin-induced thermogenesis during the development of type 2 diabetes. (1999) (96)
- Multiple disturbances of free fatty acid metabolism in noninsulin-dependent diabetes. Effect of oral hypoglycemic therapy. (1985) (95)
- Long-term changes in insulin action and insulin secretion associated with gain, loss, regain and maintenance of body weight (2000) (95)
- Free fatty acid metabolism and obesity in man: in vivo in vitro comparisons. (1986) (93)
- Missing Heritability and GWAS Utility (2009) (89)
- A C-reactive protein promoter polymorphism is associated with type 2 diabetes mellitus in Pima Indians. (2003) (89)
- TCF7L2 Is Not a Major Susceptibility Gene for Type 2 Diabetes in Pima Indians (2007) (88)
- A common variant in PPP1R3 associated with insulin resistance and type 2 diabetes. (1998) (88)
- Ethnic differences in sympathetic nervous system-mediated energy expenditure. (1991) (87)
- Higher fasting plasma concentrations of glucagon-like peptide 1 are associated with higher resting energy expenditure and fat oxidation rates in humans. (2006) (87)
- Impaired insulin-stimulated muscle glycogen synthase activation in vivo in man is related to low fasting glycogen synthase phosphatase activity. (1988) (86)
- Increased Rate of Cori Cycle in Obese Subjects With NIDDM and Effect of Weight Reduction (1988) (86)
- Effect of elevated FFA on carbohydrate and lipid oxidation during prolonged exercise in humans. (1986) (86)
- Effects of an Ala54Thr polymorphism in the intestinal fatty acid-binding protein on responses to dietary fat in humans. (2000) (85)
- Concomitant interindividual variation in body temperature and metabolic rate. (1992) (81)
- Variants in the interleukin 6 receptor gene are associated with obesity in Pima Indians. (2003) (81)
- Subcutaneous abdominal adipocyte size, a predictor of type 2 diabetes, is linked to chromosome 1q21--q23 and is associated with a common polymorphism in LMNA in Pima Indians. (2001) (79)
- Relation of the white blood cell count to obesity and insulin resistance: effect of race and gender. (1995) (79)
- The role of insulin receptor substrate-1 gene (IRS1) in type 2 diabetes in Pima Indians. (2003) (79)
- Association of amino acid variants in the activating transcription factor 6 gene (ATF6) on 1q21-q23 with type 2 diabetes in Pima Indians. (2006) (78)
- Racial difference in body core temperature between Pima Indian and Caucasian men. (1995) (77)
- Effects of acute hyperinsulinemia on plasma leptin concentrations in insulin-sensitive and insulin-resistant Pima Indians. (1996) (77)
- Lower energy expenditure predicts long-term increases in weight and fat mass. (2013) (77)
- Muscle Sympathetic Nerve Activity in Response to Glucose Ingestion: Impact of Plasma Insulin and Body Fat (1994) (74)
- Muscle Glycogen Synthesis and Disposition of Infused Glucose in Humans With Reduced Rates of Insulin-Mediated Carbohydrate Storage (1988) (72)
- Norepinephrine turnover and energy expenditure in Pima Indian and white men. (1993) (70)
- Variations in the vitamin D-binding protein (Gc locus) are associated with oral glucose tolerance in nondiabetic Pima Indians. (1998) (70)
- Association of dopamine D2 receptor polymorphisms Ser311Cys and TaqIA with obesity or type 2 diabetes mellitus in Pima Indians (2000) (69)
- A Human Thrifty Phenotype Associated With Less Weight Loss During Caloric Restriction (2015) (67)
- Genetic variation in UCP2 (uncoupling protein-2) is associated with energy metabolism in Pima Indians (2005) (67)
- A Genome-Wide Association Study in American Indians Implicates DNER as a Susceptibility Locus for Type 2 Diabetes (2013) (63)
- Variations in peptide YY and Y2 receptor genes are associated with severe obesity in Pima Indian men. (2005) (60)
- SIRT1 is associated with a decrease in acute insulin secretion and a sex specific increase in risk for type 2 diabetes in Pima Indians. (2011) (60)
- Differential methylation of genes in individuals exposed to maternal diabetes in utero (2017) (60)
- Insulin-sensitive tyrosine kinase: relationship with in vivo insulin action in humans. (1990) (60)
- Identification of novel putative membrane proteins selectively expressed during adipose conversion of 3T3-L1 cells. (2002) (59)
- Lower Metabolic Rate in Individuals Heterozygous for Either a Frameshift or a Functional Missense MC4R Variant (2008) (59)
- Identification of differentially expressed genes in skeletal muscle of non-diabetic insulin-resistant and insulin-sensitive Pima Indians by differential display PCR (2003) (59)
- Variants in hepatocyte nuclear factor 4alpha are modestly associated with type 2 diabetes in Pima Indians. (2005) (59)
- Comparison of carbohydrate-containing and carbohydrate-restricted hypocaloric diets in the treatment of obesity. Endurance and metabolic fuel homeostasis during strenuous exercise. (1981) (59)
- Absence of Linkage of Obesity and Energy Metabolism to Markers Flanking Homologues of Rodent Obesity Genes in Pima Indians (1996) (58)
- Melanocortin 4 receptor gene variation is associated with severe obesity in Pima Indians. (2004) (58)
- Overnutrition induced decrease in insulin action for glucose storage: in vivo and in vitro in man. (1986) (57)
- Potential epigenetic dysregulation of genes associated with MODY and type 2 diabetes in humans exposed to a diabetic intrauterine environment: an analysis of genome-wide DNA methylation. (2014) (57)
- Evidence for Linkage Between a Region on Chromosome 1p and the Acute Insulin Response in Pima Indians (1995) (56)
- Strong Parent-of-Origin Effects in the Association of KCNQ1 Variants With Type 2 Diabetes in American Indians (2013) (56)
- A Ser311Cys mutation in the human dopamine receptor D2 gene is associated with reduced energy expenditure. (2001) (53)
- FGF21 Is a Hormonal Mediator of the Human “Thrifty” Metabolic Phenotype (2018) (53)
- A novel missense substitution (Val1483Ile) in the fatty acid synthase gene (FAS) is associated with percentage of body fat and substrate oxidation rates in nondiabetic Pima Indians. (2004) (53)
- Greater Impact of Melanocortin-4 Receptor Deficiency on Rates of Growth and Risk of Type 2 Diabetes During Childhood Compared With Adulthood in Pima Indians (2011) (53)
- Plasma concentrations of macrophage migration inhibitory factor are elevated in Pima Indians compared to Caucasians and are associated with insulin resistance (2002) (53)
- Linkage Analysis of Acute Insulin Secretion With GLUT2 and Glucokinase in Pima Indians and the Identification of a Missense Mutation in GLUT2 (1994) (52)
- Insulin Action in Obese Non-Insulin-Dependent Diabetics and in Their Isolated Adipocytes Before and After Weight Loss (1987) (51)
- Acute insulin response is an independent predictor of type 2 diabetes mellitus in individuals with both normal fasting and 2‐h plasma glucose concentrations (2007) (51)
- Common Variation in SIM1 Is Reproducibly Associated With BMI in Pi ma Indians (2009) (50)
- Plasma concentrations of free triiodothyronine predict weight change in euthyroid persons. (2007) (50)
- Regulation of plasma lactate concentration in resting human subjects. (1990) (50)
- Thermogenic response to insulin and glucose infusions in man: a model to evaluate the different components of the thermic effect of carbohydrate. (1982) (49)
- Comparison of carbohydrate-containing and carbohydrate-restricted hypocaloric diets in the treatment of obesity: effects of appetite and mood. (1982) (48)
- Reduced early insulin secretion in the etiology of type 2 diabetes mellitus in Pima Indians. (2002) (48)
- Elevated plasma nonesterified fatty acids are associated with deterioration of acute insulin response in IGT but not NGT. (2003) (47)
- Exaggerated insulin secretion in Pima Indians and African‐Americans but higher insulin resistance in Pima Indians compared to African‐Americans and Caucasians (2004) (46)
- Studies of the etiology of obesity in Pima Indians. (1991) (46)
- Energy expenditure in the obese: is there a thrifty gene? (1990) (45)
- Hyperglycemia stimulates carbohydrate oxidation in humans. (1987) (45)
- Evaluation of A2BP1 as an Obesity Gene (2010) (44)
- Plasma leptin responses to fasting in Pima Indians. (1997) (43)
- Exaggerated pancreatic polypeptide secretion in Pima Indians: can an increased parasympathetic drive to the pancreas contribute to hyperinsulinemia, obesity, and diabetes in humans? (2001) (43)
- The effects of short-term overfeeding on adipocyte metabolism in Pima Indians. (1985) (43)
- Insulin response of components of whole-body and muscle carbohydrate metabolism in humans. (1988) (42)
- Insulin Resistance in the Pathogenesis of NIDDM in Pima Indians (1993) (42)
- Changing habits to delay diabetes. (2001) (41)
- Differential Expression of Matrix Metalloproteinase 3 (MMP3) in Preadipocytes/Stromal Vascular Cells From Nonobese Nondiabetic Versus Obese Nondiabetic Pima Indians (2006) (40)
- Metabolic effects of the Gly1057Asp polymorphism in IRS-2 and interactions with obesity. (2003) (40)
- Association analyses of variants in the DIO2 gene with early-onset type 2 diabetes mellitus in Pima Indians. (2012) (39)
- Lower “Awake and Fed Thermogenesis” Predicts Future Weight Gain in Subjects With Abdominal Adiposity (2013) (39)
- ABCC8 R1420H Loss-of-Function Variant in a Southwest American Indian Community: Association With Increased Birth Weight and Doubled Risk of Type 2 Diabetes (2015) (38)
- Reduced skeletal muscle calpain-10 transcript level is due to a cumulative decrease in major isoforms. (2001) (38)
- Variant in the regulatory subunit of phosphatidylinositol 3-kinase (p85alpha): preliminary evidence indicates a potential role of this variant in the acute insulin response and type 2 diabetes in Pima women. (1998) (38)
- Bimodal distribution of RNA expression levels in human skeletal muscle tissue (2011) (37)
- Defective insulin response of phosphorylase phosphatase in insulin-resistant humans. (1992) (37)
- In vitro insensitivity of glucose transport and antilipolysis to insulin due to receptor and postreceptor abnormalities in obese Pima Indians with normal glucose tolerance. (1984) (37)
- CHRM3 Gene Variation Is Associated With Decreased Acute Insulin Secretion and Increased Risk for Early-Onset Type 2 Diabetes in Pima Indians (2006) (36)
- Glycogen synthase: a putative locus for diet-induced hyperglycemia. (1994) (35)
- Genetic variation in the human winged helix/forkhead transcription factor gene FOXC2 in Pima Indians. (2003) (35)
- Evidence for reduced thermic effect of insulin and glucose infusions in Pima Indians. (1985) (34)
- Variants in ARHGEF11, a Candidate Gene for the Linkage to Type 2 Diabetes on Chromosome 1q, Are Nominally Associated With Insulin Resistance and Type 2 Diabetes in Pima Indians (2007) (33)
- Parasympathetic blockade attenuates augmented pancreatic polypeptide but not insulin secretion in Pima Indians. (2004) (33)
- Variants in ACAD10 are associated with type 2 diabetes, insulin resistance and lipid oxidation in Pima Indians (2010) (33)
- HLA-DRB1 reduces the risk of type 2 diabetes mellitus by increased insulin secretion (2011) (33)
- Impaired Metabolic Flexibility to High-Fat Overfeeding Predicts Future Weight Gain in Healthy Adults (2019) (33)
- Analysis of MGEA5 on 10q24.1-q24.3 encoding the beta-O-linked N-acetylglucosaminidase as a candidate gene for type 2 diabetes mellitus in Pima Indians. (2002) (32)
- Fasting hyperglycemia predicts lower rates of weight gain by increased energy expenditure and fat oxidation rate. (2015) (31)
- Greater Impact of Melanocortin-4 Receptor De fi ciency on Rates of Growth and Risk of Type 2 Diabetes Mellitus During Childhood Compared With Adulthood in Pima Indians (2011) (31)
- Defective insulin response of cyclic adenosine monophosphate-dependent protein kinase in insulin-resistant humans. (1991) (31)
- Glucose-6-phosphate stimulation of human muscle glycogen synthase phosphatase. (1988) (31)
- Whole Exome Sequencing Identifies Variation in CYB5A and RNF10 Associated with Adiposity and Type 2 Diabetes (2013) (31)
- Effects of carbohydrate-containing and carbohydrate-restricted hypocaloric and eucaloric diets on serum concentrations of retinol-binding protein, thyroxine-binding prealbumin and transferrin. (1983) (30)
- Lack of IRS-1 codon 513 and 972 polymorphism in Pima Indians. (1995) (30)
- Glycemic response to stress is altered in euglycemic Pima Indians. (1994) (30)
- Pima Indians as a model to study the genetics of NIDDM (1992) (30)
- A Genome‐Wide Association Study of BMI in American Indians (2011) (29)
- Linkage Disequilibrium Mapping of the Replicated Type 2 Diabetes Linkage Signal on Chromosome 1q (2009) (28)
- A Genome-Wide Association Study Using a Custom Genotyping Array Identifies Variants in GPR158 Associated With Reduced Energy Expenditure in American Indians (2017) (28)
- Variants in the Cav2.3 (α1E) Subunit of Voltage-Activated Ca2+ Channels Are Associated With Insulin Resistance and Type 2 Diabetes in Pima Indians (2007) (28)
- Lower total fasting plasma adiponectin concentrations are associated with higher metabolic rates. (2006) (27)
- Linkage between stature and a region on chromosome 20 and analysis of a candidate gene, bone morphogenetic protein 2. (1995) (27)
- Common genetic variation in the glucokinase gene (GCK) is associated with type 2 diabetes and rates of carbohydrate oxidation and energy expenditure (2014) (27)
- The hyperbolic law—a 25-year perspective (2005) (26)
- Molecular characterization of the human PEA15 gene on 1q21-q22 and association with type 2 diabetes mellitus in Pima Indians. (2000) (26)
- Common genetic variation in and near the melanocortin 4 receptor gene (MC4R) is associated with body mass index in American Indian adults and children (2014) (26)
- MAP2K3 is associated with body mass index in American Indians and Caucasians and may mediate hypothalamic inflammation (2013) (26)
- Association of the glycogen synthase locus on 19q13 with NIDDM in Pima Indians (1996) (26)
- Variants in the LEPR gene are nominally associated with higher BMI and lower 24 hour energy expenditure in Pima Indians (2012) (25)
- The effect of propranolol on free fatty acid mobilization and resting metabolic rate. (1989) (25)
- Pathogenesis of NIDDM in Pima Indians (1991) (24)
- Analysis of linkage disequilibrium between polymorphisms in the KCNJ9 gene with type 2 diabetes mellitus in Pima Indians. (2001) (24)
- Where all the glucose doesn't go in non-insulin-dependent diabetes mellitus. (1990) (24)
- Molecular analysis of KCNJ10 on 1q as a candidate gene for Type 2 diabetes in Pima Indians. (2002) (24)
- Variants in ASK1 Are Associated With Skeletal Muscle ASK1 Expression, In Vivo Insulin Resistance, and Type 2 Diabetes in Pima Indians (2010) (23)
- Evidence for a Role of LPGAT1 in Influencing BMI and Percent Body Fat in Native Americans (2012) (23)
- Analysis of the SIM1 Contribution to Polygenic Obesity in the French Population (2010) (23)
- Endogenous glucose production, insulin sensitivity, and insulin secretion in normal glucose-tolerant Pima Indians with low birth weight. (2004) (23)
- Protein tyrosine phosphatase 1B is not a major susceptibility gene for type 2 diabetes mellitus or obesity among Pima Indians (2007) (21)
- Analysis of SLC16A11 Variants in 12,811 American Indians: Genotype-Obesity Interaction for Type 2 Diabetes and an Association With RNASEK Expression (2015) (20)
- Evaluation of the microsomal glutathione S-transferase 3 (MGST3) locus on 1q23 as a Type 2 diabetes susceptibility gene in Pima Indians (2003) (20)
- Risk Factors for the Development of Obesity (1993) (20)
- Insulin sensitivity in adipocytes from subjects with varying degrees of glucose tolerance. (1986) (19)
- Functional Variants in MBL2 Are Associated With Type 2 Diabetes and Pre-Diabetes Traits in Pima Indians and the Old Order Amish (2010) (19)
- Perspective: Does insulin resistance primarily affect skeletal muscle? (1989) (19)
- Polymorphisms in the oxygen-regulated protein 150 gene (ORP150) are associated with insulin resistance in Pima Indians. (2002) (19)
- A cis-eQTL in PFKFB2 is associated with diabetic nephropathy, adiposity and insulin secretion in American Indians. (2015) (18)
- Energy expenditure during normo- and overfeeding in peripubertal children of lean and obese Pima Indians. (1989) (18)
- Identification of genetic variation that determines human trehalase activity and its association with type 2 diabetes (2013) (18)
- Mutations in the genes for hepatocyte nuclear factor (HNF)-1alpha, -4alpha, -1beta, and -3beta; the dimerization cofactor of HNF-1; and insulin promoter factor 1 are not common causes of early-onset type 2 diabetes in Pima Indians. (2000) (18)
- PCLO Variants Are Nominally Associated With Early-Onset Type 2 Diabetes and Insulin Resistance in Pima Indians (2008) (18)
- Identification of Susceptibility Genes for Complex Metabolic Diseases (2002) (18)
- Deficiency in phosphorylase phosphatase activity despite elevated protein phosphatase type-1 catalytic subunit in skeletal muscle from insulin-resistant subjects. (1991) (18)
- The effect of insulin on net lipid oxidation predicts worsening of insulin resistance and development of type 2 diabetes mellitus. (2007) (18)
- Analysis of slc19a2, on 1q23.3 encoding a thiamine transporter as a candidate gene for type 2 diabetes mellitus in pima indians. (2001) (17)
- Insulin resistance in Pima Indians. A combined effect of genetic predisposition and obesity-related skeletal muscle cell hypertrophy. (2009) (17)
- Cloning, expression and genomic structure of human LMX1A, and variant screening in Pima Indians. (2002) (17)
- A Functional Tyr1306Cys Variant in LARG Is Associated With Increased Insulin Action in Vivo (2006) (17)
- Polymorphism in the 3' untranslated region of MTG8 is associated with obesity in Pima Indian males. (1998) (17)
- Skeletal muscle glycogen synthase activity in subjects with non-insulin-dependent diabetes mellitus after glyburide therapy. (1990) (16)
- Palmitate oxidation rate and action on glycogen synthase in myoblasts from insulin-resistant subjects. (2000) (16)
- Association of a F479L variant in the cytosolic phospholipase A2 gene (PLA2G4A) with decreased glucose turnover and oxidation rates in Pima Indians. (2003) (16)
- Assessing variation across 8 established East Asian loci for type 2 diabetes mellitus in American Indians: Suggestive evidence for new sex‐specific diabetes signals in GLIS3 and ZFAND3 (2017) (16)
- Analysis of PBX1 as a candidate gene for type 2 diabetes mellitus in Pima Indians. (2001) (15)
- Postabsorptive respiratory quotient and insulin-stimulated glucose storage rate in nondiabetic pima indians are related To glycogen synthase fractional activity in cultured myoblasts. (1998) (15)
- A type 2 diabetes-associated polymorphic ARE motif affecting expression of PPP1R3 is involved in RNA-protein interactions. (1999) (15)
- Positional Cloning of an Obesity/Diabetes Susceptibility Gene(s) on Chromosome 11 in Pima Indians (2002) (14)
- Effect of Paternal Diabetes on Pre-Diabetic Phenotypes in Adult Offspring (2010) (14)
- Autoantibodies against PFDN2 are associated with an increased risk of type 2 diabetes: A case‐control study (2017) (14)
- Molecular and linkage analysis of type-1 protein phosphatase catalytic beta-subunit gene: lack of evidence for its major role in insulin resistance in Pima Indians (1995) (13)
- Assessment of established HDL-C loci for association with HDL-C levels and type 2 diabetes in Pima Indians (2016) (13)
- Adenosine 3',5'-monophosphate-dependent protein kinase activity decreases in human muscle after insulin infusion. (1989) (13)
- The Role of Glucose Allostasis in Type 2 Diabetes (2004) (13)
- Use of a High-Density Protein Microarray to Identify Autoantibodies in Subjects with Type 2 Diabetes Mellitus and an HLA Background Associated with Reduced Insulin Secretion (2015) (12)
- T‐cell receptor repertoire variation may be associated with type 2 diabetes mellitus in humans (2016) (12)
- Euglycemic hyperinsulinemia increases glucose 1,6-bisphosphate in human skeletal muscle. (1989) (11)
- Palmitate action to inhibit glycogen synthase and stimulate protein phosphatase 2A increases with risk factors for type 2 diabetes. (2008) (11)
- 35th Annual meeting of the European Association for the Study of Diabetes. Brussels, Belgium, 28 September-2 October, 1999. Abstracts. (1999) (11)
- Association analysis of Krüppel-like factor 11 variants with type 2 diabetes in Pima Indians. (2008) (11)
- Glucose-induced thermogenesis and insulin resistance in man. (1985) (10)
- Assessing the Role of 98 Established Loci for Body Mass Index in American Indians (2019) (10)
- Characterization of exome variants and their metabolic impact in 6,716 American Indians from Southwest US (2020) (10)
- Salsalate has no effect on insulin secretion but decreases insulin clearance: a randomized, placebo‐controlled trial in subjects without diabetes (2015) (9)
- VO2max is associated with measures of energy expenditure in sedentary condition but does not predict weight change. (2019) (9)
- Functional and association analysis of an Amerindian-derived population-specific p.(Thr280Met) variant in RBPJL, a component of the PTF1 complex (2018) (8)
- Assessing FOXO1A as a Potential Susceptibility Locus for Type 2 Diabetes and Obesity in American Indians (2015) (8)
- The transcribed endosulfine alpha gene is located within a type 2 diabetes-linked region on 1q: sequence and expression analysis in Pima Indians. (2004) (7)
- Relationship between carbohydrate oxidation and G-1,6-P2 in human skeletal muscle during euglycemic hyperinsulinemia. (1991) (7)
- Currently identified genes affecting insulin resistance are not associated with birth weight in the Pima population (2002) (7)
- The interaction of free fatty acids in radioimmunoassays for reverse triiodothyronine. (1982) (7)
- Next generation sequencing and the classical HLA loci in full heritage Pima Indians of Arizona: Defining the core HLA variation for North American Paleo-Indians. (2019) (7)
- Protein targeting to glycogen/PPP1R5: screening of coding and flanking genomic regions for polymorphisms and association analysis with insulin action in Pima Indians. (1999) (6)
- Polymorphism screening of the insulin receptor-related receptor gene (INSRR) on 1q in Pima Indians. (2001) (6)
- Insulin-sensitive tyrosine kinase activity changes in parallel with plasma insulin and glucose concentrations in humans. (1991) (6)
- Variants in ASK 1 are Associated with Skeletal Muscle ASK 1 Expression , in vivo Insulin Resistance , and Type 2 Diabetes in Pima Indians Running (2010) (6)
- Genomewide Search forGenesInfluencing Percent BodyFatinPima Indians: Suggestive Linkage atChromosome 11q21-q22 (1997) (6)
- Antecedent events for non-insulin dependent diabetes mellitus. (1988) (5)
- Metabolic fuels and the capacity for exercise during hypocaloric diet. (1981) (5)
- Tyrosine kinase activity of skeletal muscle during insulin infusion in humans. (1992) (5)
- Differences in Oral Temperature and Body Shape in Two Populations with Different Propensities for Obesity (2002) (5)
- Insulin-mediated increase in glucose 1,6-bisphosphate is attenuated in skeletal muscle of insulin-resistant man. (1990) (5)
- Agonist: the case for insulin resistance as a necessary and sufficient cause of type II diabetes mellitus. (1995) (5)
- Obesity Triggers: Sequencing the Genome vs Sequencing the Environment (2017) (5)
- The pathogenesis of obesity in man: results of studies on Pima Indians. (1990) (5)
- Assessing Accuracy of Genotype Imputation in American Indians (2014) (5)
- Relationship between obesity and maximal insulin-stimulated glucose uptake in vivo and in vitro in man. (1985) (4)
- Short-term energy balance: relationship with protein (1988) (4)
- Variant screening of PRKAB2, a type 2 diabetes mellitus susceptibility candidate gene on 1q in Pima Indians. (2002) (4)
- 1490-P: Using Longitudinal Modeling to Find One-Hour Glucose Alternatives to Two-Hour Glucose for Prediction and Diagnosis of Glucose Tolerance (2019) (3)
- Identification and functional analysis of a novel G310D variant in the insulin‐like growth factor 1 receptor (IGF1R) gene associated with type 2 diabetes in American Indians (2018) (3)
- Serum androgens in hyperinsulinemic Pima Indian and obese Caucasian women and their response to short-term insulin infusion (1993) (3)
- Exome sequencing identifies a nonsense variant in DAO associated with reduced energy expenditure in American Indians. (2020) (3)
- Does insulin resistance primarily affect skeletal muscle? (1989) (3)
- Energy expenditure and body-weight gain. (1988) (3)
- Exome Sequencing of 21 Bardet‐Biedl Syndrome (BBS) Genes to Identify Obesity Variants in 6,851 American Indians (2021) (3)
- Perspectives in Diabetes Glucose Allostasis (2003) (3)
- Decline in the acute insulin response in relationship to plasma glucose concentrations (2018) (3)
- Genome-wide scan for CAG/CTG repeat expansions in Pimas with early onset of type 2 diabetes mellitus. (1999) (2)
- Erratum to “A C-reactive protein promoter polymorphism is associated with type 2 diabetes mellitus in Pima Indians” [Mol. Genet. Metab. 78 (2003) 136–144] (2003) (2)
- Fasting plasma lipoprotein concentrations and the development of non- insulin dependent diabetes mellitus (1997) (2)
- Recent epidemiological contributions to the pathogenesis and etiology of non-insulin dependent diabetes. (1987) (2)
- Glucose allostasis: Disrobing common wisdom (2009) (2)
- Relationships betweenInsulin Secretion, Insulin Action, andFasting Plasma GlucoseConcentration inNondiabetic andNoninsulin-dependent Diabetic Subjects (1984) (2)
- The 24h carbohydrate oxidation rate in a human respiratory chamber predicts ad libitum food intake 1 – 3 (2007) (2)
- Functional and association analysis of an Amerindian-derived population-specific p.(Thr280Met) variant in RBPJL, a component of the PTF1 complex (2018) (1)
- Assessing established BMI variants for a role in nighttime eating behavior in robustly phenotyped Southwestern American Indians (2020) (1)
- Relationship Between Insulin Secretion and Insulin Sensitivity and its Role in Development of Type 2 Diabetes Mellitus: Beyond the Disposition Index. (2021) (1)
- Sensitivity of glucose uptake to insulin in vitro and in vivo in obese Pima Indians. (1985) (1)
- 1715-P: Identifying Potentially Functional Variants in Regulatory Regions in KCNQ1 that Associate with Type 2 Diabetes in American Indians (2019) (1)
- A missense variant Arg611Cys in LIPE which encodes hormone sensitive lipase decreases lipolysis and increases risk of type 2 diabetes in American Indians (2021) (1)
- 1709-P: Assessing the Role of 211 “Established” Type 2 Diabetes Variants in American Indians (2019) (1)
- Putative association signals identified through high-density LD mapping of the replicated T2D linkage region on chromosome 1q are not confirmed in large-scale follow-up studies (2008) (1)
- Functional characterization of a novel p.Ser76Thr variant in IGFBP4 that associates with body mass index in American Indians (2022) (1)
- Functional variants in cytochrome b5 type A (CYB5A) are enriched in Southwest American Indian individuals and associate with obesity (2022) (0)
- Impaired Insulin-stimulat ed MuscleGlycogenSynthaseActivation InVivoinMan IsRelated toLowFasting GlycogenSynthasePhosphatase Activity (1988) (0)
- Generation of Isogenic hiPSCs with Targeted Edits at Multiple Intronic SNPs to Study the Effects of the Type 2 Diabetes Associated KCNQ1 Locus in American Indians (2022) (0)
- Next generation sequencing for HLA loci in full heritage Pima Indians of Arizona, Part II: HLA-A, -B, and -C with selected non-classical loci at 4-field resolution from whole genome sequences. (2021) (0)
- 2018-P: Whole-Genome Sequence Identifies Potentially Functional Variants in Cytochrome B5 Type A (CYB5A) that Associate with Obesity in Southwest American Indians (2020) (0)
- Functional Variants in MBL2 are Associated with Type 2 diabetes and Pre- diabetic Traits in Pima Indians and the Old Order Amish Running Title: MBL2 and Type 2 diabetes (2010) (0)
- Common genetic variation in and near the melanocortin 4 receptor gene (MC4R) is associated with body mass index in American Indian adults and children (2014) (0)
- 2116-P: A Pipeline to Explore Rare Variation Which Can Contribute to Extreme Obesity in American Indians (2019) (0)
- 271-OR: Whole-Exome Sequence Identifies Potentially Functional Rare Variants in Bardet-Biedl Syndrome (BBS) Genes that Associate with Obesity in American Indians (2019) (0)
- Relationship Between Insulin Secretion and Insulin Sensitivity and Its Role in Development of Type 2 Diabetes: Beyond the Disposition Index (2021) (0)
- Relationship Between Insulin Secretion and Insulin Sensitivity and its Role in Development of Type 2 Diabetes Mellitus: Beyond the Disposition Index. (2021) (0)
- 301-OR: Modeling the Type 2 Diabetes–Associated ABCC8 Arg1420 His Mutation using iPSC–Derived Pancreatic Islet-Like Cells (2022) (0)
- Large-scale association studies to identify diabetes-susceptibility loci on chromosome 1q: The importance of stringent quality control (2006) (0)
- Clinical aspects of insulin action in skeletal muscle (1989) (0)
- [Non-insulin-dependent diabetes mellitus: what we have learnt from studies carried out among Pima Indians]. (1990) (0)
- 200-OR: Optimal Use of Measures of Insulin Secretion and Sensitivity in Predicting Diabetes: Beyond the Disposition Index (2021) (0)
- Variation in the retinoid X receptor gamma gene is associated with type 2 diabetes in sample sets displaying linkage to chromosome 1q (2006) (0)
- Erratum. Impaired Metabolic Flexibility to High-Fat Overfeeding Predicts Future Weight Gain in Healthy Adults. Diabetes 2020;69:181–192 (2021) (0)
- Thermic Effect of Inf used Glucose and Insulin in Man DECREASEDRESPONSE WITH INCREASED INSULIN RESISTANCE IN OBESITY AND NONINSULIN-DEPENDENT DIABETES MELLITUS (2013) (0)
- Identification of Novel Alternatively Spliced Transcripts of RBMS3 in Skeletal Muscle with Correlations to Insulin Action in vivo (2009) (0)
- Nicotine: its extraction, estimation, and physical properties (0)
- A Low-Frequency Amerindian Specific Variant in PALD1, a Negative Regulator of Insulin Signaling, Associates with Type 2 Diabetes (2018) (0)
- Identification of genetic variation that determines human trehalase activity and its association with type 2 diabetes (2013) (0)
- Relationship Between Insulin Secretion and Insulin Sensitivity and its Role in Development of Type 2 Diabetes Mellitus: Beyond the Disposition Index (2021) (0)
- 1977-P: Whole-Exome Sequencing Followed by Functional Analysis to Identify Variants That May Influence Body Mass Index (BMI) via a Role in Adipogenesis (2020) (0)
- Replicated association between type 2 diabetes and variants in CAPON revealed by high density linkage disequilibrium mapping on chromosome 1q (2006) (0)
- OBESITY (1941) (0)
- Increased homozygosity at four microsatellite marker loci in Pima Indian DNA (1994) (0)
- The effect of paternal diabetes on pre-diabetic phenotypes in adult offspring A short running title : Paternal inheritance and pre-diabetic phenotypes (2010) (0)
- Regulation ofGlycogen Synthase andPhosphorylase Activities byGlucoseandInsulin inHumanSkeletal Muscle (1987) (0)
- Large-scale follow-up study does not confirm putative association signals in the NOS1AP and PKLR gene regions on chromosome 1q with type 2 diabetes (2008) (0)
- Low Serum Insulinlike Growth Factor II Levels Correlate with High BMI in American Indian Adults (2020) (0)
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