Constance E. Brinckerhoff

Constance E. Brinckerhoff's AcademicInfluence.com Rankings

Biology

#10000

World Rank

#13277

Historical Rank

#2473

USA Rank

Microbiology

#736

World Rank

#810

Historical Rank

#141

USA Rank

biology Degrees

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Biology

Constance E. Brinckerhoff's Degrees

Bachelors Microbiology University of California, Berkeley
Masters Microbiology Stanford University

Why Is Constance E. Brinckerhoff Influential?

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According to Wikipedia, Constance E. Brinckerhoff is an American microbiologist and an emeritus professor of medicine at the Geisel School of Medicine. Life Brinckerhoff was born to social worker Elizabeth E. Zimmerman and physician Maurice K. Laurence.

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Constance E. Brinckerhoff's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Matrix metalloproteinases: a tail of a frog that became a prince (2002) (1122)
Matrix metalloproteinases: role in arthritis. (2006) (1095)
Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors (2001) (718)
Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3. (2000) (625)
Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma: a potential mechanism of lesion stabilization. (1998) (611)
A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter creates an Ets binding site and augments transcription. (1998) (564)
The AP-1 site and MMP gene regulation: what is all the fuss about? (1997) (514)
Interstitial collagenases as markers of tumor progression. (2000) (345)
Regulating expression of the gene for matrix metalloproteinase-1 (collagenase): mechanisms that control enzyme activity, transcription, and mRNA stability. (1996) (270)
Nuclear factor kappaB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1beta-stimulated synovial fibroblasts. (1998) (237)
IL-1 induces collagenase-3 (MMP-13) promoter activity in stably transfected chondrocytic cells: requirement for Runx-2 and activation by p38 MAPK and JNK pathways. (2001) (236)
Rat collagenase. Cloning, amino acid sequence comparison, and parathyroid hormone regulation in osteoblastic cells. (1990) (235)
Using inhibitors of metalloproteinases to treat arthritis. Easier said than done? (1994) (205)
Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2α in von Hippel–Lindau renal cell carcinoma (2005) (180)
Signal transduction and cell‐type specific regulation of matrix metalloproteinase gene expression: Can MMPs be good for you? (2007) (178)
Matrix metalloproteinases as therapeutic targets in arthritic diseases: bull's-eye or missing the mark? (2002) (168)
Autocrine induction of collagenase by serum amyloid A-like and beta 2-microglobulin-like proteins. (1989) (158)
Inhibition by retinoic acid of collagenase production in rheumatoid synovial cells. (1980) (154)
Manganese Superoxide Dismutase Signals Matrix Metalloproteinase Expression via H2O2-dependent ERK1/2 Activation* (2001) (153)
Early response genes induced in chondrocytes stimulated with the inflammatory cytokine interleukin-1beta (2001) (152)
Overexpression of Collagenase 1 (MMP-1) Is Mediated by the ERK Pathway in Invasive Melanoma Cells (2004) (151)
The AP-1 sequence is necessary but not sufficient for phorbol induction of collagenase in fibroblasts. (1991) (149)
Half-life of synovial cell collagenase mRNA is modulated by phorbol myristate acetate but not by all-trans-retinoic acid or dexamethasone. (1986) (128)
Molecular targets in osteoarthritis: metalloproteinases and their inhibitors. (2007) (126)
Joint destruction in arthritis: metalloproteinases in the spotlight. (1991) (121)
Collagenase production by synovial fibroblasts treated with phorbol myristate acetate. (1979) (118)
Cell‐type specific regulation of human interstitial collagenase‐1 gene expression by interleukin‐1β (IL‐1β) in human fibroblasts and BC‐8701 breast cancer cells (1997) (115)
Induction of collagenase and stromelysin gene expression by mechanical injury in a vascular smooth muscle‐derived cell line (1993) (112)
Post‐Transcriptional regulationa of collagenase and stromelysin gene expression by epidermal growth factor and dexamethasone in cultured human fibroblasts (1992) (106)
A Novel Host/Tumor Cell Interaction Activates Matrix Metalloproteinase 1 and Mediates Invasion through Type I Collagen* (1999) (106)
Serum amyloid A (SAA3) produced by rabbit synovial fibroblasts treated with phorbol esters or interleukin 1 induces synthesis of collagenase and is neutralized with specific antiserum. (1991) (103)
Matrix metalloproteinase-1 and thrombin differentially activate gene expression in endothelial cells via PAR-1 and promote angiogenesis. (2008) (99)
Cloning of the genes for human stromelysin and stromelysin 2: differential expression in rheumatoid synovial fibroblasts. (1989) (99)
A Matrix Metalloproteinase-1/Protease Activated Receptor-1 signaling axis promotes melanoma invasion and metastasis (2009) (95)
A gene for rabbit synovial cell collagenase: member of a family of metalloproteinases that degrade the connective tissue matrix. (1987) (95)
Transforming growth factor beta inhibitory element in the rabbit matrix metalloproteinase-1 (collagenase-1) gene functions as a repressor of constitutive transcription. (2000) (95)
Cloning of the gene for interstitial collagenase-3 (matrix metalloproteinase-13) from rabbit synovial fibroblasts: differential expression with collagenase-1 (matrix metalloproteinase-1). (1998) (93)
RNA interference inhibition of matrix metalloproteinase-1 prevents melanoma metastasis by reducing tumor collagenase activity and angiogenesis. (2007) (92)
Collagenase production by rheumatoid synovial cells: morphological and immunohistochemical studies of the dendritic cell. (1979) (89)
Synergistic induction of matrix metalloproteinase 1 by interleukin-1alpha and oncostatin M in human chondrocytes involves signal transducer and activator of transcription and activator protein 1 transcription factors via a novel mechanism. (2001) (87)
Regulation of collagenase gene expression by IL-1 beta requires transcriptional and post-transcriptional mechanisms. (1994) (86)
Interleukin-1 or phorbol induction of the stromelysin promoter requires an element that cooperates with AP-1. (1991) (85)
Biosynthesis and secretion of procollagenase by rabbit synovial fibroblasts. Inhibition of procollagenase secretion by monensin and evidence for glycosylation of procollagenase. (1983) (85)
Two activator protein-1 elements in the matrix metalloproteinase-1 promoter have different effects on transcription and bind Jun D, c-Fos, and Fra-2. (1995) (84)
Basic Calcium Phosphate Crystals Induce Matrix Metalloproteinase-1 through the Ras/Mitogen-activated Protein Kinase/c-Fos/AP-1/Metalloproteinase 1 Pathway (2002) (82)
Collagenase immunolocalization in cultures of rheumatoid synovial cells. (1978) (79)
Transcriptional Repression of Matrix Metalloproteinase Gene Expression by the Orphan Nuclear Receptor NURR1 in Cartilage* (2007) (79)
Identification of a cigarette smoke-responsive region in the distal MMP-1 promoter. (2009) (79)
Cloning of a complementary DNA for rabbit proactivator. A metalloproteinase that activates synovial cell collagenase, shares homology with stromelysin and transin, and is coordinately regulated with collagenase. (1987) (78)
CXCR4 and Matrix Metalloproteinase-1 Are Elevated in Breast Carcinoma–Associated Fibroblasts and in Normal Mammary Fibroblasts Exposed to Factors Secreted by Breast Cancer Cells (2009) (78)
Modulation by retinoic acid and corticosteroids of collagenase production by rabbit synovial fibroblasts treated with phorbol myristate acetate or poly(ethylene glycol). (1981) (74)
Increased proliferation of human synovial fibroblasts treated with recombinant immune interferon. (1985) (73)
A synthetic triterpenoid selectively inhibits the induction of matrix metalloproteinases 1 and 13 by inflammatory cytokines. (2001) (72)
Short hairpin RNA-mediated inhibition of matrix metalloproteinase-1 in MDA-231 cells: effects on matrix destruction and tumor growth. (2005) (71)
Erk 1/2 differentially regulates the expression from the 1G/2G single nucleotide polymorphism in the MMP-1 promoter in melanoma cells. (2002) (71)
A precursor form of latent collagenase produced in a cell-free system with mRNA from rabbit synovial cells. (1981) (70)
Consequences of altered TGF-β expression and responsiveness in breast cancer: evidence for autocrine and paracrine effects (2002) (64)
Fra-1 targets the AP-1 site/2G single nucleotide polymorphism (ETS site) in the MMP-1 promoter. (2003) (62)
Matrix metalloproteinase and G protein coupled receptors: co-conspirators in the pathogenesis of autoimmune disease and cancer. (2009) (58)
Matrix metalloproteinase-1 promotes breast cancer angiogenesis and osteolysis in a novel in vivo model (2009) (58)
The potential of signal transduction inhibitors for the treatment of arthritis: Is it all just JNK? (2001) (58)
BRAF Inhibition Alleviates Immune Suppression in Murine Autochthonous Melanoma (2014) (56)
Multiple murine BRafV600E melanoma cell lines with sensitivity to PLX4032 (2014) (55)
Post-transcriptional regulation of collagenase and stromelysin gene expression by epidermal growth factor and dexamethasone in cultured human fibroblasts. (1992) (54)
Elevated levels of collagenase and prostaglandin e2 from synovium associated with chronic lyme arthritis (1980) (54)
Use of agarose culture to measure the effect of transforming growth factor beta and epidermal growth factor on rabbit articular chondrocytes. (1985) (53)
Increased level of translatable collagenase messenger ribonucleic acid in rabbit synovial fibroblasts treated with phorbol myristate acetate or crystals of monosodium urate monohydrate. (1982) (53)
Role of serum amyloid A as an intermediate in the IL-1 and PMA-stimulated signaling pathways regulating expression of rabbit fibroblast collagenase. (1997) (52)
Loss of heterozygosity on chromosome 11q22-23 in melanoma is associated with retention of the insertion polymorphism in the matrix metalloproteinase-1 promoter. (2001) (52)
Isolation of a collagenase cDNA clone and measurement of changing collagenase mRNA levels during induction in rabbit synovial fibroblasts. (1984) (51)
Diesel Exhaust Particles Activate the Matrix-Metalloproteinase-1 Gene in Human Bronchial Epithelia in a β-Arrestin–Dependent Manner via Activation of RAS (2008) (51)
The acute phase reactant serum amyloid A (SAA3) is a novel substrate for degradation by the metalloproteinases collagenase and stromelysin. (1993) (51)
Heat shock of rabbit synovial fibroblasts increases expression of mRNAs for two metalloproteinases, collagenase and stromelysin (1989) (51)
Potential for the 2G single nucleotide polymorphism in the promoter of matrix metalloproteinase to enhance gene expression in normal stromal cells. (2002) (50)
Rabbit procollagenase synthesized and secreted by a high-yield mammalian expression vector requires stromelysin (matrix metalloproteinase-3) for maximal activation. (1990) (49)
Regulation of metalloproteinase gene expression: implications for osteoarthritis. (1992) (49)
PTEN suppression of YY1 induces HIF-2 activity in von hippel lindau null renal cell carcinoma (2009) (49)
Survival of rheumatoid synovium implanted into nude mice. (1981) (47)
src-related tyrosine kinases regulate transcriptional activation of the interstitial collagenase gene, MMP-1, in interleukin-1-stimulated synovial fibroblasts. (1996) (46)
Relationship of procollagenase activator, stromelysin and matrix metalloproteinase 3. (1988) (46)
BRAFV600E melanoma cells secrete factors that activate stromal fibroblasts and enhance tumourigenicity (2014) (46)
Molecular cloning of human synovial cell collagenase and selection of a single gene from genomic DNA. (1987) (45)
Tumor cell invasion of von Hippel Lindau renal cell carcinoma cells is mediated by membrane type-1 matrix metalloproteinase (2006) (45)
The 2G Single Nucleotide Polymorphism (SNP) in the MMP-1 Promoter Contributes to High Levels of MMP-1 Transcription in MCF-7/ADR Breast Cancer Cells (2003) (43)
Cell-type specific regulation of human interstitial collagenase-1 gene expression by interleukin-1 beta (IL-1 beta) in human fibroblasts and BC-8701 breast cancer cells. (1997) (42)
Nuclear hormone receptors inhibit matrix metalloproteinase (MMP) gene expression through diverse mechanisms. (1996) (41)
Novel inhibitors of matrix metalloproteinase gene expression as potential therapies for arthritis. (2004) (38)
Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses (2021) (37)
Regulation of Collagenase Gene Expression in Synovial Fibroblasts a (1990) (36)
Regulation of matrix metalloproteinase gene expression by a retinoid X receptor-specific ligand. (2007) (36)
Human breast cancer cells activate procollagenase-1 and invade type I collagen: invasion is inhibited by all-trans retinoic acid (1999) (35)
Peroxisome proliferator-activated receptor-gamma-independent repression of collagenase gene expression by 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and prostaglandin 15-deoxy-delta(12,14) J2: a role for Smad signaling. (2004) (35)
Iron increases collagenase production by rabbit synovial fibroblasts. (1981) (35)
Retinoid‐Mediated Suppression of Tumor Invasion and Matrix Metalloproteinase Synthesis (1999) (34)
Collagen production by cultures containing multinucleated cells derived from synovial fibroblasts. (1978) (33)
ETS sites in the promoters of the matrix metalloproteinases collagenase (MMP-1) and stromelysin (MMP-3) are auxiliary elements that regulate basal and phorbol-induced transcription. (1997) (33)
Transcriptional repression of the human collagenase-1 (MMP-1) gene in MDA231 breast cancer cells by all-trans-retinoic acid requires distal regions of the promoter (1999) (32)
Synthesis of PGE2, collagenase and tissue factor by fibroblast substrains: substrains are differentially activated for different metabolic products. (1985) (32)
Differential regulation of collagenase gene expression by retinoic acid receptors—α, β and γ (1992) (32)
Selective modulation of collagenase 1 gene expression by the chemotherapeutic agent doxorubicin. (1999) (31)
Regulation of Extrahepatic Apolipoprotein Serum Amyloid A (ApoSAA) Gene Expression by Interleukin‐1α Alone: Synthesis and Secretion of ApoSAA by Cultured Aortic Smooth Muscle Cells (1997) (29)
Morphologic and mitogenic responses of rabbit synovial fibroblasts to transforming growth factor β require transforming growth factor α or epidermal growth factor (1983) (29)
Elevated levels of collagenase and prostaglandin E2 from synovium associated with erosion of cartilage and bone in a patient with chronic Lyme arthritis. (1980) (28)
Induction of collagenase mRNA in lapine articular chondrocytes by synovial factors and interleukin-1. (1988) (27)
Autoregulation of collagenase production by a protein synthesized and secreted by synovial fibroblasts: cellular mechanism for control of collagen degradation. (1985) (27)
Collagenase production by cloned populations of rabbit synovial fibroblasts. (1981) (25)
Retinoid X receptor and peroxisome proliferator-activated receptor-gamma agonists cooperate to inhibit matrix metalloproteinase gene expression (2008) (24)
Transcriptional regulation of the collagenase gene by basic fibroblast growth factor in osteoblastic MC3T3-E1 cells. (1995) (24)
The synthetic retinoid (4-hydroxyphenyl)retinamide decreases collagen expression in vitro and in the tight-skin mouse. (1993) (23)
Distal Interleukin-1β (IL-1β) Response Element of Human Matrix Metalloproteinase-13 (MMP-13) Binds Activator Protein 1 (AP-1) Transcription Factors and Regulates Gene Expression* (2011) (23)
CXCR3 Signaling in BRAFWT Melanoma Increases IL-8 Expression and Tumorigenicity (2015) (22)
The mitogen-activated protein kinase pathway plays a critical role in regulating immunological properties of BRAF mutant cutaneous melanoma cells (2016) (21)
Posttranscriptional regulation of collagenase-1 gene expression in synoviocytes by adenosine receptor stimulation. (1997) (20)
Retinoids and rheumatoid arthritis: modulation of extracellular matrix by controlling expression of collagenase. (1990) (20)
A TLR7 agonist strengthens T and NK cell function during BRAF‐targeted therapy in a preclinical melanoma model (2019) (19)
Effects of all-trans-retinoic acid (retinoic acid) and 4-hydroxyphenylretinamide on synovial cells and articular cartilage. (1982) (19)
The BRAFV600E inhibitor, PLX4032, increases type I collagen synthesis in melanoma cells (2015) (19)
Autocrine control of collagenase synthesis by synovial fibroblasts (1988) (18)
Activation of the MMP-1 promoter by cigarette smoke in human small airway epithelial cells requires ERK MAP kinase signaling: differential response of the 1G and 2G promoter sequences. (2006) (18)
Analysis of Matrix Metalloproteinase-1 Gene Polymorphisms and Expression in Benign and Malignant Breast Tumors (2011) (16)
Expression of stromelysin and stromelysin-2 in rabbit and human fibroblasts. (1992) (16)
Retinoids and rexinoids for the 21st century: a brave new world for arthritis. (2003) (14)
The nuclear receptor corepressor SMRT inhibits interstitial collagenase (MMP-1) transcription through an HRE-independent mechanism. (1997) (14)
Selective retinoic acid receptor ligands for rheumatoid arthritis. (2004) (12)
Effect of retinoids on rheumatoid arthritis, a proliferative and invasive non-malignant disease. (2008) (12)
Transcriptional regulation of matrix metalloproteinase genes: role of AP-1 sequences. (1992) (11)
Site controlled transgenic mice validating increased expression from human matrix metalloproteinase (MMP-1) promoter due to a naturally occurring SNP. (2009) (10)
Homology between exon-containing portions of rabbit genomic clones for synovial cell collagenase and human foreskin and synovial cell mRNAs. (1986) (10)
Morphologic and mitogenic responses of rabbit synovial fibroblasts to transforming growth factor beta require transforming growth factor alpha or epidermal growth factor. (1983) (9)
Prolonged inhibition of protein and glycoprotein synthesis in tumor cells treated with muconomycin A. (1977) (9)
Confocal assay for invasion: use of propidium iodide fluorescence and laser reflectance to quantify the rate of migration of cells through a matrix. (2000) (8)
Characterization of rabbit genes for synovial cell collagenase. (1986) (8)
Differential regulation of collagenase gene expression by retinoic acid receptors--alpha, beta and gamma. (1992) (7)
CXCR 4 and Matrix Metalloproteinase-1 Are Elevated in Breast Carcinoma – Associated Fibroblasts and in Normal Mammary Fibroblasts Exposed to Factors Secreted by Breast Cancer Cells (2009) (7)
Interstitial Collagenases as Markers of Tumor Progression 1 (2000) (6)
Secretion of inflammatory mediators from synovial fibroblasts: dissociation of collagenase and prostaglandin release. (1980) (5)
Wild‐type versus mutant MMP‐8 in melanoma: ‘When you come to a fork in the road, take it’ * (2009) (5)
“Matrix Metalloproteinases: They’re Not Just for Matrix Anymore!” (2017) (4)
Patterns of regulation of collagen breakdown in articular cartilage (1981) (4)
Increased tumor immunity in mice inoculated with muconomycin A-treated B16 melanoma cells. (1978) (4)
Sialic acid-deficient tumor cells: inhibition of sialoglycoprotein synthesis by emetine. (1974) (4)
Saturable, high affinity binding of serum amyloid A (SAA3) to rabbit fibroblasts (1995) (4)
Matrix Metalloproteinases in Health and Disease:Sculpting the Human Body (2017) (4)
Collagenase release from synovial fibroblasts: relationship to fatty acid release and prostaglandin synthesis (1980) (2)
The Collagenases: Novel Roles for Matrix Metalloproteinases (MMPS) in Invasion and Metastasis (2002) (1)
Specificity of glucocorticoid inhibition of synovial prostaglandin synthesis (1980) (1)
Regulation of collagenase gene expression in synovial cells. (1987) (0)
A Brief Introduction to Proteinases (2017) (0)
Effects of lymphokines on rheumatoid arthritis. (1990) (0)
Collagenase Activity and Angiogenesis Prevents Melanoma Metastasis by Reducing Tumor RNA Interference Inhibition of Matrix Metalloproteinase-1 (2007) (0)
Matrix Metalloproteinases (MMPs) in Homeostasis and Health: Can MMPs be Good for You? (2017) (0)
Effect of a Single Nucleotide Polymorphism (NP) on Breast Cancer Invasion (2001) (0)
Matrix Metalloproteinases (MMPs) as Therapeutic Targets (2017) (0)
The role of RXR in retinoic acid-mediated suppression of collagenase gene expression (1993) (0)
What are the therapeutic implications of increased collagen expression in melanoma cells treated with vemurafenib? (2016) (0)
The 'RASor's' edge: Ras proteins and matrix destruction in arthritis (2009) (0)
Heat shock of rabbit synovial fibroblasts rsf induces messenger rna expression for two metalloproteinases mps collagenase and stromelysin (1988) (0)
Nuclear receptor ligands LG268 and rosiglitazone inhibit collagen destruction by chondrocytic cells stimulated with interleukin‐1 beta (2009) (0)
Chapter 15 – Transcriptional Regulation of Matrix Metalloproteinases (2003) (0)
Abstract P4-07-09: The Impact of Matrix Metalloproteinase-1 Promoter 1G/2G Polymorphism on Breast Diseases (2010) (0)
Autoregulation of collagenase prod and secreted by synovial fibroblast control of collagen degradation (phorbol myristate acetate/connective tissue regulation/immunopreci (2016) (0)
Through the Looking Glass into the Era of Precision Medicine (2017) (0)
Erratum (2020) (0)
Editorial The 'RASor's' edge: Ras proteins and matrix destruction in (2009) (0)
Potential for the 2 G Single Nucleotide Polymorphism in the Promoter of Matrix Metalloproteinase to Enhance Gene Expression in Normal Stromal Cells 1 (2002) (0)
JCP anniversary issue: Seventy‐five years of milestones in cellular physiology (2007) (0)

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