Cornelia van Duijn
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Epidemiologist
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Cornelia van Duijn's Degrees
- PhD Epidemiology Erasmus University Rotterdam
- Masters Epidemiology Erasmus University Rotterdam
- Bachelors Biology Leiden University
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Why Is Cornelia van Duijn Influential?
(Suggest an Edit or Addition)According to Wikipedia, Cornelia M. van Duijn is a Dutch epidemiologist. She is Professor of Epidemiology at Nuffield Department of Population Health and a Fellow of St Cross College, Oxford. Life Cornelia van Duijn studied human nutrition and mathematical statistics at the Agricultural University of Wageningen, and genetics and epidemiology at Erasmus University Medical School.
Cornelia van Duijn's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids (2010) (3485)
- Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism (2002) (2622)
- Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. (1997) (2488)
- Discovery and Refinement of Loci Associated with Lipid Levels (2013) (2475)
- New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (2010) (2087)
- Variant of TREM2 associated with the risk of Alzheimer's disease. (2013) (2004)
- Hundreds of variants clustered in genomic loci and biological pathways affect human height (2010) (1961)
- Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk (2011) (1928)
- Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes (2012) (1839)
- Defining the role of common variation in the genomic and biological architecture of adult human height (2014) (1805)
- GenABEL: an R library for genome-wide association analysis (2007) (1781)
- Six new loci associated with body mass index highlight a neuronal influence on body weight regulation (2009) (1735)
- Common variants in ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease (2011) (1701)
- The Rotterdam Study: 2010 objectives and design update (2007) (1257)
- Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease (2014) (1230)
- New genetic loci link adipose and insulin biology to body fat distribution (2014) (1227)
- Association analyses of 249,796 individuals reveal eighteen new loci associated with body mass index (2010) (1179)
- Genome-wide analysis of genetic loci associated with Alzheimer disease. (2010) (1177)
- Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis (2013) (1170)
- Genome-wide association study identifies 74 loci associated with educational attainment (2016) (1114)
- Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) (1073)
- Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture (2012) (1045)
- A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants (2015) (1024)
- The UK10K project identifies rare variants in health and disease (2015) (926)
- Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts (2009) (909)
- Low-penetrance susceptibility to breast cancer due to CHEK2*1100delC in noncarriers of BRCA1 or BRCA2 mutations (2002) (860)
- GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment (2013) (803)
- Updated clinical diagnostic criteria for sporadic Creutzfeldt-Jakob disease (2009) (782)
- Common variants associated with plasma triglycerides and risk for coronary artery disease (2013) (767)
- Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways (2012) (758)
- Seven New Loci Associated with Age-Related Macular Degeneration (2013) (741)
- Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries (2018) (735)
- Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans (2015) (724)
- Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease (2017) (693)
- Twenty bone mineral density loci identified by large-scale meta-analysis of genome-wide association studies (2009) (687)
- Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease. (2001) (667)
- Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (2018) (659)
- The Generation R Study: design and cohort update 2017 (2016) (654)
- Genome-Wide Association Study of Retinopathy in Individuals without Diabetes (2013) (651)
- Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity (2016) (634)
- Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia. (2016) (630)
- Genetic and physiological data implicating the new human gene G72 and the gene for d-amino acid oxidase in schizophrenia (2002) (602)
- Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes (2018) (578)
- Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture (2013) (568)
- Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses (2016) (563)
- The Generation R Study: design and cohort update 2010 (2010) (553)
- The Generation R Study: design and cohort update 2012 (2012) (553)
- An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans (2017) (547)
- The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (2015) (532)
- Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution (2009) (516)
- The Generation R Study: design and cohort update until the age of 4 years (2008) (516)
- Rare and low-frequency coding variants alter human adult height (2016) (511)
- Parent-of-origin specific allelic associations among 106 genomic loci for age at menarche (2014) (511)
- Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children (2011) (508)
- Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE statement (2009) (494)
- STrengthening the REporting of Genetic Association Studies (STREGA)— An Extension of the STROBE Statement (2009) (482)
- Genetic association of apolipoprotein E with age-related macular degeneration. (1998) (478)
- Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels (2011) (476)
- Frontotemporal dementia in The Netherlands: patient characteristics and prevalence estimates from a population-based study. (2003) (471)
- Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA (2016) (471)
- Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals (2012) (459)
- Meta-analyses of genetic studies on major depressive disorder (2008) (445)
- Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer disease. (1998) (437)
- ProbABEL package for genome-wide association analysis of imputed data (2010) (437)
- Genome-wide association study of PR interval (2010) (432)
- Genetic risk of primary open-angle glaucoma. Population-based familial aggregation study. (1998) (428)
- Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk (2017) (428)
- Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure (2011) (424)
- High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in the Netherlands. (1999) (418)
- Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease (2010) (417)
- Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function (2018) (417)
- Erratum: Detection and interpretation of shared genetic influences on 42 human traits (2016) (417)
- Maternal Use of Antiepileptic Drugs and the Risk of Major Congenital Malformations: A Joint European Prospective Study of Human Teratogenesis Associated with Maternal Epilepsy (1997) (414)
- Genetic prion disease: the EUROCJD experience (2005) (403)
- Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study. (1998) (399)
- Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function (2016) (388)
- A polymorphism in the gene for IGF-I: functional properties and risk for type 2 diabetes and myocardial infarction. (2001) (385)
- Park7, a novel locus for autosomal recessive early-onset parkinsonism, on chromosome 1p36. (2001) (384)
- The Rotterdam Study: 2016 objectives and design update (2015) (383)
- Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry (2009) (382)
- Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence (2017) (380)
- The Rotterdam Study: 2018 update on objectives, design and main results (2017) (375)
- A genome-wide association meta-analysis identifies new childhood obesity loci (2012) (375)
- Genetic risk of age-related maculopathy. Population-based familial aggregation study. (1998) (372)
- Genome-wide associations for birth weight and correlations with adult disease (2016) (371)
- Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium (2009) (369)
- Complement factor H polymorphism, complement activators, and risk of age-related macular degeneration. (2006) (366)
- Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits (2013) (365)
- APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy. (2006) (355)
- Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. (2002) (354)
- Quantifying prion disease penetrance using large population control cohorts (2016) (352)
- Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1 (2010) (350)
- Genetic fine-mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci (2015) (349)
- The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals (2016) (347)
- Genome-wide patterns and properties of de novo mutations in humans (2015) (345)
- Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction (2010) (345)
- Novel Associations of Multiple Genetic Loci With Plasma Levels of Factor VII, Factor VIII, and von Willebrand Factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium (2010) (344)
- Disease variants alter transcription factor levels and methylation of their binding sites (2015) (341)
- Increasing Prevalence of Myopia in Europe and the Impact of Education (2015) (339)
- Genome-wide meta-analysis identifies new susceptibility loci for migraine (2013) (336)
- The Rotterdam Study: objectives and design update (2007) (334)
- Identification of context-dependent expression quantitative trait loci in whole blood (2016) (332)
- The Rotterdam Study: 2012 objectives and design update (2011) (329)
- Mortality from Creutzfeldt–Jakob disease and related disorders in Europe, Australia, and Canada (2005) (329)
- META-ANALYSIS OF GENOME-WIDE ASSOCIATION STUDIES IDENTIFIES THREE NEW RISK LOCI FOR ATOPIC DERMATITIS (2011) (325)
- Multiple Genetic Loci Influence Serum Urate Levels and Their Relationship With Gout and Cardiovascular Disease Risk Factors (2010) (323)
- Genome-based prediction of common diseases: advances and prospects. (2008) (319)
- Antiepileptic drug regimens and major congenital abnormalities in the offspring (1999) (318)
- Common polygenic variation enhances risk prediction for Alzheimer's disease. (2015) (316)
- Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation. (1997) (314)
- Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile (2011) (313)
- Prevalence of refractive error in Europe: the European Eye Epidemiology (E3) Consortium (2015) (312)
- The Rotterdam Study: 2014 objectives and design update (2013) (304)
- New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism (2012) (300)
- The impact of low-frequency and rare variants on lipid levels (2015) (300)
- Genome-wide association study of intracranial aneurysm identifies three new risk loci (2010) (298)
- Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel (2015) (296)
- Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes (2017) (294)
- Predicting Type 2 Diabetes Based on Polymorphisms From Genome-Wide Association Studies (2008) (292)
- Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks. (2014) (292)
- A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease (2017) (288)
- Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome (2018) (288)
- Genome-Wide Association Study for Coronary Artery Calcification With Follow-Up in Myocardial Infarction (2011) (286)
- Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials (2011) (281)
- Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder. (2015) (281)
- NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium (2009) (281)
- CSF tests in the differential diagnosis of Creutzfeldt-Jakob disease (2006) (277)
- A critical appraisal of the scientific basis of commercial genomic profiles used to assess health risks and personalize health interventions. (2008) (276)
- Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism (2015) (276)
- Epidemiology of Alzheimer's disease. (1992) (273)
- Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited (2011) (273)
- Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption (2011) (270)
- Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors (2018) (269)
- Correction: Corrigendum: Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis (2015) (268)
- Collaborative Meta-analysis: Associations of 150 Candidate Genes With Osteoporosis and Osteoporotic Fracture (2009) (267)
- ACE polymorphisms. (2006) (266)
- Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration (2011) (264)
- Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases (2012) (263)
- Common genetic variants associated with cognitive performance identified using the proxy-phenotype method (2014) (262)
- Predictors of survival in sporadic Creutzfeldt-Jakob disease and other human transmissible spongiform encephalopathies. (2004) (261)
- Determinants of diagnostic investigation sensitivities across the clinical spectrum of sporadic Creutzfeldt-Jakob disease. (2006) (261)
- Genetic and environmental influences interact with age and sex in shaping the human methylome (2016) (260)
- The Genome of the Netherlands: design, and project goals (2013) (260)
- Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization (2014) (260)
- A Genomic Background Based Method for Association Analysis in Related Individuals (2007) (259)
- The Generation R Study Biobank: a resource for epidemiological studies in children and their parents (2007) (253)
- Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene. (2008) (253)
- Fine-Mapping the Genetic Association of the Major Histocompatibility Complex in Multiple Sclerosis: HLA and Non-HLA Effects (2013) (252)
- A large‐scale population‐based study of the association of vitamin D receptor gene polymorphisms with bone mineral density (1996) (252)
- A catalog of genetic loci associated with kidney function from analyses of a million individuals (2019) (252)
- Psychiatric history and related exposures as risk factors for Alzheimer's disease: a collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group. (1991) (252)
- Best Practices and Joint Calling of the HumanExome BeadChip: The CHARGE Consortium (2013) (250)
- Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight (2010) (250)
- Genome-wide analysis identifies 12 loci influencing human reproductive behavior (2016) (250)
- Genomewide association studies of stroke. (2009) (247)
- A NOVEL ALZHEIMER DISEASE LOCUS LOCATED NEAR THE GENE ENCODING TAU PROTEIN (2015) (246)
- New insights into the genetic etiology of Alzheimer’s disease and related dementias (2022) (246)
- New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk (2016) (242)
- PredictABEL: an R package for the assessment of risk prediction models (2011) (240)
- Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age (2014) (238)
- Novel genetic loci associated with hippocampal volume (2017) (238)
- Predictive testing for complex diseases using multiple genes: Fact or fiction? (2006) (232)
- Association between genetic variation in the gene for insulin-like growth factor-l and low birthweight (2002) (229)
- GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy. (2015) (229)
- Common variants at 12q14 and 12q24 are associated with hippocampal volume (2012) (227)
- Genome-wide association meta-analysis for total serum bilirubin levels. (2009) (224)
- Familial aggregation of Alzheimer's disease and related disorders: a collaborative re-analysis of case-control studies. (1991) (222)
- Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis. (2008) (220)
- A Genome-Wide Association Study of Optic Disc Parameters (2010) (216)
- Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque (2011) (214)
- Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci (2016) (214)
- Genome-wide analysis of multiethnic cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma (2014) (212)
- Alcohol and tobacco consumption as risk factors for Alzheimer's disease: a collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group. (1991) (209)
- Large-scale association analyses identify host factors influencing human gut microbiome composition (2020) (206)
- Large meta-analysis establishes the ACE insertion-deletion polymorphism as a marker of Alzheimer's disease. (2005) (205)
- Association of 5' estrogen receptor alpha gene polymorphisms with bone mineral density, vertebral bone area and fracture risk. (2003) (203)
- Relation between nicotine intake and Alzheimer's disease. (1991) (200)
- The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis (2013) (199)
- Genetic evidence of assortative mating in humans (2017) (199)
- Genetic Determinants of Circulating Sphingolipid Concentrations in European Populations (2009) (199)
- KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference (2016) (198)
- Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol. (2014) (197)
- Rapid variance components–based method for whole-genome association analysis (2012) (196)
- The Generation R Study: Biobank update 2015 (2014) (195)
- Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure underpinning obesity (2017) (193)
- Novel genetic loci underlying human intracranial volume identified through genome-wide association (2016) (192)
- Descriptive epidemiology of Creutzfeldt‐Jakob disease in six european countries, 1993–1995 (1998) (188)
- Familial aggregation in frontotemporal dementia (1998) (187)
- Shared Constitutional Risks for Maternal Vascular-Related Pregnancy Complications and Future Cardiovascular Disease (2008) (186)
- Reducing the genetic risk of age-related macular degeneration with dietary antioxidants, zinc, and ω-3 fatty acids: the Rotterdam study. (2011) (186)
- Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease. (2006) (186)
- Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility (2015) (185)
- Genome-Wide Association Studies of Serum Magnesium, Potassium, and Sodium Concentrations Identify Six Loci Influencing Serum Magnesium Levels (2010) (185)
- Common Genetic Determinants of Intraocular Pressure and Primary Open-Angle Glaucoma (2012) (185)
- Relation between smoking and risk of dementia and Alzheimer disease (2007) (184)
- Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels (2019) (183)
- Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations (2012) (181)
- Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function (2012) (180)
- Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels (2015) (179)
- Genome‐wide association studies of cerebral white matter lesion burden (2011) (178)
- Association of Hypertension Drug Target Genes With Blood Pressure and Hypertension in 86 588 Individuals (2011) (178)
- Association of Genome-Wide Variation With the Risk of Incident Heart Failure in Adults of European and African Ancestry: A Prospective Meta-Analysis From the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium (2010) (177)
- Hippocampal, amygdalar, and global brain atrophy in different apolipoprotein E genotypes (2002) (176)
- Genetic adaptation of fatty-acid metabolism: a human-specific haplotype increasing the biosynthesis of long-chain omega-3 and omega-6 fatty acids. (2012) (176)
- Medical history and the risk of Alzheimer's disease: a collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group. (1991) (174)
- Interaction Between Hypertension, apoE, and Cerebral White Matter Lesions (2004) (171)
- Identification of a Rare Coding Variant in Complement 3 Associated with Age-related Macular Degeneration (2013) (171)
- Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects. (2018) (171)
- Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation (2018) (171)
- Vitamin D receptor genotype is associated with radiographic osteoarthritis at the knee. (1997) (170)
- Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis (2014) (170)
- Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals. (2010) (168)
- Polymorphism in the IGF-I gene: clinical relevance for short children born small for gestational age (SGA). (2002) (168)
- A Genome-Wide Association Study of Depressive Symptoms (2013) (166)
- Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium (2015) (164)
- A Genome-Wide Association Study Reveals Variants in ARL15 that Influence Adiponectin Levels (2009) (164)
- The effect of genetic drift in a young genetically isolated population. (2005) (163)
- Heritabilities of radiologic osteoarthritis in peripheral joints and of disc degeneration of the spine. (1999) (163)
- Genetic risk profiles for depression and anxiety in adult and elderly cohorts (2010) (163)
- Common genetic variants associated with open-angle glaucoma. (2011) (161)
- Serum copper and zinc and the risk of death from cancer and cardiovascular disease. (1988) (159)
- A meta-analysis of genome-wide association studies identifies multiple longevity genes (2019) (158)
- Blood lipids influence DNA methylation in circulating cells (2016) (156)
- Four Novel Loci (19q13, 6q24, 12q24, and 5q14) Influence the Microcirculation In Vivo (2010) (156)
- A pooled case-control study of the apolipoprotein E (APOE) gene in age-related maculopathy (2002) (155)
- Genome-wide association analysis identifies multiple loci related to resting heart rate. (2010) (154)
- Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults (2017) (153)
- The Trans-Ancestral Genomic Architecture of Glycemic Traits (2020) (151)
- Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. (2014) (150)
- Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits (2017) (149)
- Meta-analyses identify 13 novel loci associated with age at menopause and highlights DNA repair and immune pathways (2011) (149)
- Genetic architecture of subcortical brain structures in 38,851 individuals (2019) (148)
- A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population. (2007) (148)
- Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error (2018) (147)
- Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels (2016) (147)
- The impact of genotype frequencies on the clinical validity of genomic profiling for predicting common chronic diseases (2007) (146)
- Computational pan-genomics: status, promises and challenges (2016) (145)
- Loci influencing blood pressure identified using a cardiovascular gene-centric array. (2013) (145)
- Directional dominance on stature and cognition in diverse human populations (2015) (144)
- Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. (2013) (143)
- Insights into the Genetic Architecture of Early Stage Age-Related Macular Degeneration: A Genome-Wide Association Study Meta-Analysis (2013) (141)
- Cdx‐2 Polymorphism in the Promoter Region of the Human Vitamin D Receptor Gene Determines Susceptibility to Fracture in the Elderly (2003) (140)
- Interaction Between the Vitamin D Receptor Gene and Collagen Type Iα1 Gene in Susceptibility for Fracture (2001) (140)
- A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals (2019) (139)
- A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. (2010) (139)
- Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits (2018) (139)
- Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI (2015) (139)
- SIRT1 Genetic Variation Is Related to BMI and Risk of Obesity (2009) (139)
- The Molecular Genetic Architecture of Self-Employment (2013) (137)
- Risk factors for Creutzfeldt‐Jakob disease (1996) (137)
- Nucleotide Excision DNA Repair Is Associated With Age-Related Vascular Dysfunction (2012) (137)
- Genome-wide association study of smoking initiation and current smoking. (2009) (136)
- History of dementia and Parkinson's disease in 1st‐degree relatives of patients with Alzheimer's disease (1989) (136)
- Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study (2016) (135)
- Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer’s disease: A prospective study in eight cohorts (2018) (134)
- Cerebrospinal fluid biomarker supported diagnosis of Creutzfeldt–Jakob disease and rapid dementias: a longitudinal multicentre study over 10 years (2012) (134)
- Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites. (2005) (133)
- New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics (2017) (133)
- Parkinson's disease: piecing together a genetic jigsaw. (2003) (132)
- The apolipoprotein E ε2 allele is associated with an increased risk of early‐onset alzheimer's disease and a reduced survival (1995) (130)
- Interaction between genetic and environmental risk factors for Alzheimer's disease: A reanalysis of case‐control studies (1994) (129)
- The power of genetic diversity in genome-wide association studies of lipids (2021) (129)
- Adiposity as a cause of cardiovascular disease: a Mendelian randomization study. (2015) (128)
- Reproductive period and risk of dementia in postmenopausal women. (2001) (128)
- Genetic contributions to glaucoma: heritability of intraocular pressure, retinal nerve fiber layer thickness, and optic disc morphology. (2007) (127)
- Large meta-analysis of genome-wide association studies identifies five loci for lean body mass (2017) (127)
- Estrogen receptor alpha gene haplotype is associated with radiographic osteoarthritis of the knee in elderly men and women. (2003) (126)
- Relationship between gut microbiota and circulating metabolites in population-based cohorts (2019) (125)
- GWAS for executive function and processing speed suggests involvement of the CADM2 gene (2016) (125)
- Genetic overlap between Alzheimer’s disease and Parkinson’s disease at the MAPT locus (2015) (124)
- Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression (2020) (124)
- Cholesterol and age-related macular degeneration: is there a link? (2004) (124)
- Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease (2015) (124)
- Multiple Loci Are Associated with White Blood Cell Phenotypes (2011) (123)
- Common variants at 12q15 and 12q24 are associated with infant head circumference (2012) (121)
- Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney (2017) (121)
- Heritability of the Function and Structure of the Arterial Wall: Findings of the Erasmus Rucphen Family (ERF) Study (2005) (121)
- Retinal vessel diameters and risk of impaired fasting glucose or diabetes: the Rotterdam study. (2006) (121)
- Improving Phenotypic Prediction by Combining Genetic and Epigenetic Associations (2015) (120)
- Predicting human height by Victorian and genomic methods (2009) (120)
- Leveraging Cross-Species Transcription Factor Binding Site Patterns: From Diabetes Risk Loci to Disease Mechanisms (2014) (120)
- Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course. (2013) (120)
- Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC review. (2007) (119)
- Head trauma and the risk of Alzheimer's disease. (1992) (119)
- Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region (2012) (118)
- Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies (2016) (118)
- Association of the interleukin-1 gene cluster with radiographic signs of osteoarthritis of the hip. (2004) (117)
- Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity (2017) (117)
- Medical and environmental risk factors for sporadic frontotemporal dementia: a retrospective case–control study (2003) (117)
- The risk of overanticoagulation in patients with cytochrome P450 CYP2C9*2 or CYP2C9*3 alleles on acenocoumarol or phenprocoumon. (2004) (115)
- Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. (2009) (115)
- Estrogen use and early onset Alzheimer's disease: a population-based study (1999) (114)
- Common genetic variants associate with serum phosphorus concentration. (2010) (114)
- Survival in Elderly Persons with Down Syndrome (2008) (113)
- Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory (2014) (113)
- Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness (2017) (113)
- Aldehyde Dehydrogenase 2 and Head and Neck Cancer: A Meta-analysis Implementing a Mendelian Randomization Approach (2009) (113)
- Characteristics of de novo structural changes in the human genome (2015) (113)
- Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes (2013) (113)
- A novel common variant in DCST2 is associated with length in early life and height in adulthood (2014) (112)
- Risk factors for Alzheimer's disease: overview of the EURODEM collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group. (1991) (112)
- The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data (2011) (111)
- The probabilistic model of Alzheimer disease: the amyloid hypothesis revised (2021) (110)
- Common variants at 6q22 and 17q21 are associated with intracranial volume (2012) (110)
- Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia. (2014) (110)
- The Effect of Genetic Drift in a Young Genetically Isolated Population (2005) (107)
- Apolipoprotein E genotype in patients with alzheimer's disease: Implications for the risk of dementia among relatives (1995) (107)
- Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms (2016) (106)
- PRNP Val129 homozygosity increases risk for early‐onset Alzheimer's disease (2003) (106)
- Interleukin 6 −174 G/C Promoter Polymorphism and Risk of Coronary Heart Disease: Results from the Rotterdam Study and a Meta-Analysis (2006) (106)
- Polymorphisms in metabolic genes, their combination and interaction with tobacco smoke and alcohol consumption and risk of gastric cancer: a case-control study in an Italian population (2007) (106)
- Association of Altered Liver Enzymes With Alzheimer Disease Diagnosis, Cognition, Neuroimaging Measures, and Cerebrospinal Fluid Biomarkers (2019) (106)
- Prevalence and heritability of the metabolic syndrome and its individual components in a Dutch isolate: the Erasmus Rucphen Family study (2008) (105)
- Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries (2021) (105)
- A genome‐wide association study of sleep habits and insomnia (2013) (105)
- Meta-analysis of genome-wide association studies identifies common variants in CTNNA2 associated with excitement-seeking (2011) (105)
- Strengthening the reporting of genetic association studies (STREGA): an extension of the strengthening the reporting of observational studies in epidemiology (STROBE) statement. (2009) (105)
- Challenges in conducting genome-wide association studies in highly admixed multi-ethnic populations: the Generation R Study (2015) (104)
- Renin‐angiotensin system inhibitors, angiotensin I‐converting enzyme gene insertion/deletion polymorphism, and cancer (2008) (104)
- STrengthening the REporting of Genetic Association Studies (STREGA)—an extension of the STROBE statement (2009) (104)
- Plasma phosphatidylcholine and sphingomyelin concentrations are associated with depression and anxiety symptoms in a Dutch family-based lipidomics study. (2013) (104)
- Separating the Mechanism-Based and Off-Target Actions of Cholesteryl Ester Transfer Protein Inhibitors With CETP Gene Polymorphisms (2010) (104)
- Genome-wide association study of plasma lipids (2019) (103)
- STrengthening the REporting of Genetic Association studies (STREGA) – an extension of the STROBE statement (2009) (103)
- Effects of Metformin on Metabolite Profiles and LDL Cholesterol in Patients With Type 2 Diabetes (2015) (103)
- Complement component C3 and risk of age-related macular degeneration. (2008) (103)
- Telomere length in circulating leukocytes is associated with lung function and disease (2013) (103)
- Common variants in the JAZF1 gene associated with height identified by linkage and genome-wide association analysis. (2009) (102)
- Association Between Chromosome 9p21 Variants and the Ankle-Brachial Index Identified by a Meta-Analysis of 21 Genome-Wide Association Studies (2012) (102)
- Angiotensin-Converting Enzyme Gene Polymorphism and Carotid Artery Wall Thickness: A Meta-Analysis (2003) (101)
- Heritability of blood pressure traits and the genetic contribution to blood pressure variance explained by four blood-pressure-related genes (2007) (101)
- The Alzheimer's Disease Sequencing Project: Study design and sample selection (2017) (101)
- Strengthening the reporting of genetic risk prediction studies: the GRIPS statement (2011) (101)
- A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. (2018) (100)
- Total Zinc Intake May Modify the Glucose-Raising Effect of a Zinc Transporter (SLC30A8) Variant (2011) (100)
- Power of Selective Genotyping in Genetic Association Analyses of Quantitative Traits (2000) (99)
- Dense-core senile plaques in the Flemish variant of Alzheimer's disease are vasocentric. (2002) (99)
- The risk of bleeding complications in patients with cytochrome P450 CYP2C9*2 or CYP2C9*3 alleles on acenocoumarol or phenprocoumon (2004) (99)
- Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies. (2012) (99)
- Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area. (2011) (98)
- Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine (2015) (98)
- Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine (2015) (98)
- GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes (2018) (98)
- Improved imputation quality of low-frequency and rare variants in European samples using the ‘Genome of The Netherlands' (2014) (98)
- Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk (2018) (98)
- CYP1A1, CYP2E1, GSTM1, GSTT1, EPHX1 exons 3 and 4, and NAT2 polymorphisms, smoking, consumption of alcohol and fruit and vegetables and risk of head and neck cancer (2007) (98)
- Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error (2016) (98)
- A polymorphism in the IGF-I gene influences the age-related decline in circulating total IGF-I levels. (2003) (98)
- 52 Genetic Loci Influencing Myocardial Mass. (2016) (98)
- A common polymorphism in the complement factor H gene is associated with increased risk of myocardial infarction: the Rotterdam Study. (2006) (96)
- A high-quality human reference panel reveals the complexity and distribution of genomic structural variants (2016) (96)
- Plasma amyloid β, apolipoprotein E, lacunar infarcts, and white matter lesions (2004) (95)
- The -514 C->T hepatic lipase promoter region polymorphism and plasma lipids: a meta-analysis. (2004) (95)
- Sporadic Creutzfeldt–Jakob disease and surgery: A case–control study using community controls (2002) (94)
- Genetic Variation at the Phospholipid Transfer Protein Locus Affects Its Activity and High-Density Lipoprotein Size and Is a Novel Marker of Cardiovascular Disease Susceptibility (2010) (94)
- Shared genetic factors in migraine and depression (2010) (94)
- Apolipoprotein E genotype and association between smoking and early onset Alzheimer's disease (1995) (94)
- Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids (2019) (93)
- Association of Novel Genetic Loci With Circulating Fibrinogen Levels: A Genome-Wide Association Study in 6 Population-Based Cohorts (2009) (93)
- Variance heterogeneity analysis for detection of potentially interacting genetic loci: method and its limitations (2010) (92)
- Follow-up of loci from the International Genomics of Alzheimer's Disease Project identifies TRIP4 as a novel susceptibility gene (2014) (92)
- Leukocyte telomere length associates with prospective mortality independent of immune-related parameters and known genetic markers (2014) (92)
- Alcohol intake in relation to brain magnetic resonance imaging findings in older persons without dementia. (2004) (91)
- Common Genetic Variation in the 3′-BCL11B Gene Desert Is Associated With Carotid-Femoral Pulse Wave Velocity and Excess Cardiovascular Disease Risk: The AortaGen Consortium (2012) (91)
- A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation (2009) (91)
- Prenatal exposure to the 1944-45 Dutch 'hunger winter' and addiction later in life. (2008) (90)
- European surveillance on Creutzfeldt-Jakob disease: a case-control study for medical risk factors. (2000) (90)
- Meta-analysis of genome-wide association for migraine in six population-based European cohorts (2011) (89)
- Prediction of age-related macular degeneration in the general population: the Three Continent AMD Consortium. (2013) (89)
- Shared genetic basis for migraine and ischemic stroke (2015) (89)
- Endocytic disturbances distinguish among subtypes of alzheimer's disease and related disorders (2001) (88)
- Replication of CD58 and CLEC16A as genome-wide significant risk genes for multiple sclerosis (2009) (88)
- Genome-Wide Association Studies of MRI-Defined Brain Infarcts: Meta-Analysis From the CHARGE Consortium (2010) (88)
- Genomic Variation Associated With Mortality Among Adults of European and African Ancestry With Heart Failure: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (2010) (88)
- Adjacent genes, for COL2A1 and the vitamin D receptor, are associated with separate features of radiographic osteoarthritis of the knee. (2000) (88)
- Metabolomics Profile in Depression: A Pooled Analysis of 230 Metabolic Markers in 5283 Cases With Depression and 10,145 Controls (2020) (88)
- The Role of Body Mass Index, Insulin, and Adiponectin in the Relation Between Fat Distribution and Bone Mineral Density (2009) (87)
- Genome-based prediction of common diseases: methodological considerations for future research (2009) (87)
- Revisiting the clinical validity of multiplex genetic testing in complex diseases. (2004) (87)
- Genetic variability in the regulatory region of presenilin 1 associated with risk for Alzheimer's disease and variable expression. (2000) (86)
- Genetic Architecture of Plasma Adiponectin Overlaps With the Genetics of Metabolic Syndrome–Related Traits (2010) (86)
- Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores (2021) (85)
- Discovery and functional prioritization of Parkinson’s disease candidate genes from large-scale whole exome sequencing (2017) (85)
- Apolipoprotein E and Carotid Artery Atherosclerosis: The Rotterdam Study (2001) (84)
- Estrogen Receptor β (ESR2) Polymorphisms in Interaction With Estrogen Receptor α (ESR1) and Insulin‐Like Growth Factor I (IGF1) Variants Influence the Risk of Fracture in Postmenopausal Women (2006) (84)
- Genome-wide association studies of cerebral white matter lesion burden: the CHARGE Consortium (2011) (84)
- A genetic association study of the IGF-1 gene and radiological osteoarthritis in a population-based cohort study (the Rotterdam study) (1998) (84)
- Genetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degeneration (2013) (82)
- Genomewide meta‐analysis identifies loci associated with IGF‐I and IGFBP‐3 levels with impact on age‐related traits (2016) (82)
- Genetic determinants of treatment benefit of the angiotensin-converting enzyme-inhibitor perindopril in patients with stable coronary artery disease. (2010) (81)
- Characterization of pathogenic SORL1 genetic variants for association with Alzheimer’s disease: a clinical interpretation strategy (2017) (81)
- Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes. (2012) (81)
- Use of Genome-Wide Expression Data to Mine the “Gray Zone” of GWA Studies Leads to Novel Candidate Obesity Genes (2010) (81)
- Evidence of Inbreeding Depression on Human Height (2012) (81)
- Risk factors for childhood acute non-lymphocytic leukemia: an association with maternal alcohol consumption during pregnancy? (1994) (81)
- Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals (2022) (80)
- Localization of autosomal recessive early‐onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset (2002) (80)
- Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium (2016) (80)
- Insight in Genome-Wide Association of Metabolite Quantitative Traits by Exome Sequence Analyses (2015) (80)
- Influence of timing on CSF tests value for Creutzfeldt-Jakob disease diagnosis (2007) (79)
- Population-specific genotype imputations using minimac or IMPUTE2 (2015) (78)
- The association between H63D mutations in HFE and amyotrophic lateral sclerosis in a Dutch population. (2007) (78)
- Causal Effect of Plasminogen Activator Inhibitor Type 1 on Coronary Heart Disease (2017) (78)
- Causal Effect of Plasminogen Activator Inhibitor Type 1 on Coronary Heart Disease (2017) (78)
- The Influence of an Insulin‐Like Growth Factor I Gene Promoter Polymorphism on Hip Bone Geometry and the Risk of Nonvertebral Fracture in the Elderly: The Rotterdam Study (2004) (78)
- Plasma β amyloid and the risk of Alzheimer's disease in Down syndrome (2012) (78)
- Genome-wide linkage analysis of serum creatinine in three isolated European populations. (2009) (78)
- Apolipoprotein E gene and sporadic frontal lobe dementia (1997) (77)
- Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. (2019) (77)
- ARHGEF12 influences the risk of glaucoma by increasing intraocular pressure. (2015) (76)
- Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps (2016) (75)
- Discovery and fine mapping of serum protein loci through transethnic meta-analysis. (2012) (75)
- Skewed X-inactivation is common in the general female population (2018) (75)
- Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium (2012) (75)
- Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process (2014) (75)
- Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability (2018) (74)
- Cerebrospinal fluid biomarkers in human genetic transmissible spongiform encephalopathies (2009) (74)
- Evaluation of risk prediction updates from commercial genome-wide scans (2009) (74)
- Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length (2020) (74)
- A Genome-Wide Association Scan of RR and QT Interval Duration in 3 European Genetically Isolated Populations: The EUROSPAN Project (2009) (72)
- Familial clustering and genetic risk for dementia in a genetically isolated Dutch population. (2004) (72)
- Identification of a common variant at the NOS1AP locus strongly associated to QT-interval duration. (2008) (72)
- Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation (2015) (72)
- Evaluation of a Genetic Risk Score to Improve Risk Prediction for Alzheimer's Disease. (2016) (71)
- Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE Statement (2009) (71)
- Increased High-Density Lipoprotein Levels Associated with Age-Related Macular Degeneration: Evidence from the EYE-RISK and European Eye Epidemiology Consortia. (2018) (71)
- Clinical features and neuroimaging of PARK7‐linked parkinsonism (2003) (70)
- Novel parkin mutations detected in patients with early‐onset Parkinson's disease (2005) (70)
- Maternal transmission of multiple sclerosis in a dutch population. (2008) (70)
- Human age estimation from blood using mRNA, DNA methylation, DNA rearrangement, and telomere length. (2016) (70)
- Long-term Air Pollution Exposure, Genome-wide DNA Methylation and Lung Function in the LifeLines Cohort Study (2018) (69)
- Variation in the von Willebrand factor gene is associated with von Willebrand factor levels and with the risk for cardiovascular disease. (2011) (69)
- Associations of autozygosity with a broad range of human phenotypes (2019) (68)
- Transmission of human mtDNA heteroplasmy in the Genome of the Netherlands families: support for a variable-size bottleneck (2016) (68)
- Metabolomics based markers predict type 2 diabetes in a 14-year follow-up study (2017) (68)
- Angiotensinogen Gene Promoter Haplotype and Microangiopathy-Related Cerebral Damage: Results of the Austrian Stroke Prevention Study (2001) (68)
- Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. (2012) (67)
- GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI (2019) (67)
- Epidemiology of the dementias: recent developments and new approaches. (1996) (67)
- PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION (2018) (67)
- Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error. (2013) (67)
- Insulin-resistance and metabolic syndrome are related to executive function in women in a large family-based study (2010) (67)
- Interleukin-6 Signaling Effects on Ischemic Stroke and Other Cardiovascular Outcomes (2019) (66)
- Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity (2019) (65)
- A saturated map of common genetic variants associated with human height (2022) (65)
- A metabolomic profile is associated with the risk of incident coronary heart disease. (2014) (65)
- European lactase persistence genotype shows evidence of association with increase in body mass index (2009) (65)
- Improvement of risk prediction by genomic profiling: reclassification measures versus the area under the receiver operating characteristic curve. (2010) (65)
- Genome-wide association study identifies 48 common genetic variants associated with handedness (2019) (65)
- Genetic susceptibility, dietary antioxidants, and long-term incidence of age-related macular degeneration in two populations. (2014) (64)
- Genome-wide association study of migraine implicates a common susceptibility variant on 8 q 22 . 1 (2010) (64)
- Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations. (2014) (64)
- Heritability of the shape of subcortical brain structures in the general population (2016) (64)
- A case—control study of apolipoprotein E genotypes in Alzheimer's disease associated with Down's syndrome (1995) (64)
- New insights on the genetic etiology of Alzheimer’s and related dementia (2020) (64)
- Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits. (2016) (64)
- Genetic analysis for a shared biological basis between migraine and coronary artery disease (2015) (64)
- The impact of APOE on myocardial infarction, stroke, and dementia (2004) (64)
- Angiotensin-Converting Enzyme Gene Insertion/Deletion Polymorphism and Breast Cancer Risk (2005) (64)
- Two-octapeptide repeat deletion of prion protein associated with rapidly progressive dementia (2001) (63)
- Multilocus Genetic Risk Score Associates With Ischemic Stroke in Case–Control and Prospective Cohort Studies (2014) (63)
- Exome sequencing and functional analyses suggest that SIX6 is a gene involved in an altered proliferation-differentiation balance early in life and optic nerve degeneration at old age. (2014) (63)
- Patients with an ApoE epsilon4 allele require lower doses of coumarin anticoagulants. (2005) (63)
- Modeling of Environmental Effects in Genome-Wide Association Studies Identifies SLC2A2 and HP as Novel Loci Influencing Serum Cholesterol Levels (2010) (63)
- Genomewide scan for affective disorder susceptibility Loci in families of a northern Swedish isolated population. (2005) (63)
- Age- and Sex-Specific Causal Effects of Adiposity on Cardiovascular Risk Factors (2015) (62)
- Meta-analysis of epigenome-wide association studies of cognitive abilities (2018) (62)
- Association between an insulin-like growth factor I gene promoter polymorphism and bone mineral density in the elderly: the Rotterdam Study. (2003) (62)
- Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs (2016) (62)
- Linkage and Genome‐wide Association Analysis of Obesity‐related Phenotypes: Association of Weight With the MGAT1 Gene (2010) (62)
- PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity (2018) (61)
- Risk factors for Alzheimer's disease: the EURODEM collaborative re-analysis of case-control studies. (1992) (61)
- Octapeptide repeat insertions in the prion protein gene and early onset dementia (2004) (61)
- Common variants at 6q22 and 17q21 are associated with intracranial volume (2012) (61)
- TGF-&bgr;1 Polymorphisms and Risk of Myocardial Infarction and Stroke: The Rotterdam Study (2006) (60)
- Association of matrilin-3 polymorphisms with spinal disc degeneration and osteoarthritis of the first carpometacarpal joint of the hand (2006) (60)
- A Systematic Review of Meta-Analyses on Gene Polymorphisms and Gastric Cancer Risk (2008) (60)
- Polymorphisms in the vascular endothelial growth factor gene and risk of age-related macular degeneration: the Rotterdam Study. (2008) (60)
- Cataract surgery and the risk of aging macula disorder: the rotterdam study. (2008) (60)
- Genetic evidence for a role of adiponutrin in the metabolism of apolipoprotein B-containing lipoproteins. (2009) (59)
- Apolipoprotein E genotype, atherosclerosis, and cognitive decline: the Rotterdam Study. (1998) (59)
- Migraine is not associated with enhanced atherosclerosis (2013) (59)
- A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape (2016) (59)
- Meta-analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and risk of head and neck and lung cancer. (2009) (59)
- Genetic variation associated with circulating monocyte count in the eMERGE Network. (2013) (59)
- Polymorphism in the Promoter Region of the Insulin-like Growth Factor I Gene Is Related to Carotid Intima-Media Thickness and Aortic Pulse Wave Velocity in Subjects With Hypertension (2003) (58)
- ATP5H/KCTD2 locus is associated with Alzheimer's disease risk (2013) (58)
- Apolipoprotein E genotype and progression of Alzheimer’s disease: the Rotterdam Study (1999) (58)
- Deleterious Alleles in the Human Genome Are on Average Younger Than Neutral Alleles of the Same Frequency (2013) (58)
- Alzheimer's disease in Down syndrome: An overlooked population for prevention trials (2018) (58)
- Blood-based metabolic signatures in Alzheimer's disease (2017) (58)
- The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project (2010) (58)
- Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability (2020) (58)
- Angiotensin converting enzyme insertion/deletion polymorphism and the risk of heart failure in hypertensive subjects. (2004) (58)
- Allelic Variants of Cytochrome P450 2C9 Modify the Interaction Between Nonsteroidal Anti‐inflammatory Drugs and Coumarin Anticoagulants (2005) (57)
- Association of adiposity genetic variants with menarche timing in 92,105 women of European descent. (2013) (57)
- The Impact of Partial and Complete Loss-of-Function Mutations in Endothelial Lipase on High-Density Lipoprotein Levels and Functionality in Humans (2013) (57)
- A study of gene–environment interaction on the gene for angiotensin converting enzyme: a combined functional and population based approach (2004) (57)
- Association Analysis of Bitter Receptor Genes in Five Isolated Populations Identifies a Significant Correlation between TAS2R43 Variants and Coffee Liking (2014) (56)
- Presentation of amyloidosis in carriers of the codon 692 mutation in the amyloid precursor protein gene (APP692). (2000) (56)
- Genetic association studies: genes in search of diseases. (2002) (56)
- Cerebral small vessel disease genomics and its implications across the lifespan (2020) (56)
- Cerebral small vessel disease genomics and its implications across the lifespan (2020) (56)
- Predicting Stroke Through Genetic Risk Functions: The CHARGE Risk Score Project (2014) (56)
- PET neuroimaging and mutations in the DJ-1 gene (2004) (56)
- The apolipoprotein E ε4 allele does not influence the clinical expression of the amyloid precursor protein gene codon 693 or 692 mutations (1994) (56)
- Genome-Wide Association Study of Vascular Dementia (2012) (56)
- Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases (2018) (55)
- A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level (2010) (55)
- Angiotensin converting enzyme gene polymorphism and cardiovascular morbidity and mortality: the Rotterdam Study (2005) (55)
- The Glu318Gly substitution in presenilin 1 is not causally related to Alzheimer disease. (1999) (55)
- Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene. (2005) (55)
- Familial aggregation, the PDE4D gene, and ischemic stroke in a genetically isolated population (2005) (55)
- Shared genetic contribution to ischemic stroke and Alzheimer's disease (2016) (55)
- The α2-macroglobulin gene in AD (2000) (55)
- Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease (2009) (54)
- An approach for cutting large and complex pedigrees for linkage analysis (2008) (54)
- Evidence for major gene inheritance of Alzheimer disease in families of patients with and without apolipoprotein E epsilon 4. (1996) (54)
- WNT10A exonic variant increases the risk of keratoconus by decreasing corneal thickness. (2015) (54)
- Early age at menopause is associated with increased risk of dementia and mortality in women with Down syndrome. (2010) (54)
- Maternal age and Alzheimer's disease: a collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group. (1991) (53)
- Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits (2017) (53)
- Investigation of the association of the CRTM and CRTL1 genes with radiographically evident osteoarthritis in subjects from the Rotterdam study. (1997) (53)
- Angiotensin-converting enzyme gene polymorphism and common carotid stiffness. The Rotterdam study. (2004) (53)
- Short telomere length is associated with impaired cognitive performance in European ancestry cohorts (2017) (53)
- The PCLO gene and depressive disorders: replication in a population-based study. (2010) (52)
- Point Mutation in the Stalk of Angiotensin-Converting Enzyme Causes a Dramatic Increase in Serum Angiotensin-Converting Enzyme But No Cardiovascular Disease (2001) (52)
- LPIN2 Is Associated With Type 2 Diabetes, Glucose Metabolism, and Body Composition (2007) (51)
- Linkage and association studies identify a novel locus for Alzheimer disease at 7q36 in a Dutch population-based sample. (2005) (51)
- SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin. (2009) (51)
- Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration (2011) (50)
- Occupational exposure to pesticides is associated with differential DNA methylation (2016) (50)
- Risk Scores of Common Genetic Variants for Lipid Levels Influence Atherosclerosis and Incident Coronary Heart Disease (2013) (50)
- Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia (2018) (50)
- The occurrence of Guillain-Barré syndrome within families (2004) (50)
- Expression of Type III Hyperlipoproteinemia in Apolipoprotein E2 (Arg158→Cys) Homozygotes Is Associated With Hyperinsulinemia (2002) (50)
- New Blood Pressure–Associated Loci Identified in Meta-Analyses of 475 000 Individuals (2017) (50)
- A case-control study on the effect of p53 and p73 gene polymorphisms on gastric cancer risk and progression. (2009) (49)
- Association of metformin, sulfonylurea and insulin use with brain structure and function and risk of dementia and Alzheimer’s disease: Pooled analysis from 5 cohorts (2019) (49)
- Polymorphisms of the renin–angiotensin system are associated with blood pressure, atherosclerosis and cerebral white matter pathology (2007) (49)
- Clinical features and mortality in patients with early-onset Alzheimer's disease. (1996) (49)
- Phenome-wide investigation of health outcomes associated with genetic predisposition to loneliness (2018) (49)
- An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis (2019) (49)
- Micronutrients and the risk of lung cancer. (1987) (48)
- Rare variants in γ‐aminobutyric acid type A receptor genes in rolandic epilepsy and related syndromes (2015) (48)
- A priori collaboration in population imaging: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium (2015) (48)
- An epidemiological perspective on the future of direct-to-consumer personal genome testing (2010) (48)
- Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair (2017) (47)
- Haplotype analysis of three polymorphisms of the COL2A1 gene and associations with generalised radiological osteoarthritis (1999) (47)
- The gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sample. (2002) (47)
- A pharmacogenetic analysis of determinants of hypertension and blood pressure response to angiotensin-converting enzyme inhibitor therapy in patients with vascular disease and healthy individuals (2011) (47)
- Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration (2019) (47)
- From blood to lung tissue: effect of cigarette smoke on DNA methylation and lung function (2018) (46)
- Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis. (2017) (46)
- Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults (2020) (46)
- Trans-ethnic meta-analysis of white blood cell phenotypes. (2014) (46)
- Autosomal recessive early onset parkinsonism is linked to three loci: PARK2, PARK6, and PARK7 (2002) (46)
- Estrogen receptor α polymorphisms and postmenopausal breast cancer risk (2007) (46)
- Genome‐wide association study on the FEV1/FVC ratio in never‐smokers identifies HHIP and FAM13A (2017) (46)
- Angiotensinogen M235T polymorphism and the risk of myocardial infarction and stroke among hypertensive patients on ACE-inhibitors or β-blockers (2007) (46)
- Risk genes associated with pediatric-onset MS but not with monophasic acquired CNS demyelination (2013) (46)
- CYP2E1PstI/RsaI polymorphism and interaction with tobacco, alcohol and GSTs in gastric cancer susceptibility: A meta-analysis of the literature. (2007) (46)
- Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2019) (45)
- Genome-Wide Meta-Analysis of Myopia and Hyperopia Provides Evidence for Replication of 11 Loci (2014) (45)
- IGF-I Bioactivity in an Elderly Population (2010) (45)
- A genome-wide search for linkage-disequilibrium with type 1 diabetes in a recent genetically isolated population from the Netherlands. (2002) (45)
- Human Prion Diseases in The Netherlands (1998–2009): Clinical, Genetic and Molecular Aspects (2012) (45)
- Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease (2016) (45)
- Association of cognitive functioning with retinal nerve fiber layer thickness. (2009) (45)
- CLEC4M and STXBP5 gene variations contribute to von Willebrand factor level variation in von Willebrand disease (2015) (45)
- A genome-wide association study of intra-ocular pressure suggests a novel association in the gene FAM125B in the TwinsUK cohort (2014) (44)
- CYP1A2 and coffee intake and the modifying effect of sex, age, and smoking. (2012) (44)
- Mortality in patients with hypertension on angiotensin-I converting enzyme (ACE)-inhibitor treatment is influenced by the ACE insertion/deletion polymorphism (2005) (44)
- Intensity of human prion disease surveillance predicts observed disease incidence (2013) (44)
- Gene-based pleiotropy across migraine with aura and migraine without aura patient groups (2016) (44)
- Molecular genetic aetiology of general cognitive function is enriched in evolutionarily conserved regions (2016) (43)
- Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and susceptibility to gastric adenocarcinoma in an Italian population (2007) (43)
- Early cognitive decline is associated with prion protein codon 129 polymorphism (2003) (43)
- The GenABEL Project for statistical genomics (2016) (43)
- Genome of the Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels (2015) (43)
- Multiple etiologies for Alzheimer disease are revealed by segregation analysis. (1994) (43)
- Heritability of Serum Iron, Ferritin and Transferrin Saturation in a Genetically Isolated Population, the Erasmus Rucphen Family (ERF) Study (2006) (43)
- Pharmacogenetic interactions between ABCB1 and SLCO1B1 tagging SNPs and the effectiveness of statins in the prevention of myocardial infarction. (2010) (43)
- The involvement of upstream stimulatory factor 1 in Dutch patients with familial combined hyperlipidemias⃞ Published, JLR Papers in Press, October 25, 2006. (2007) (42)
- The cholesteryl ester transfer protein (CETP) gene and the risk of Alzheimer’s disease (2007) (42)
- Linkage and association analyses of glaucoma related traits in a large pedigree from a Dutch genetically isolated population (2011) (42)
- Lipidomic profiling identifies signatures of metabolic risk (2019) (42)
- Rare Exome Sequence Variants in CLCN6 Reduce Blood Pressure Levels and Hypertension Risk (2016) (42)
- Insulin-like growth factor I promoter polymorphism, risk of stroke, and survival after stroke: the Rotterdam study (2005) (41)
- The complement component 5 gene and age-related macular degeneration. (2010) (41)
- Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities (2020) (41)
- The apolipoprotein E epsilon 2 allele is associated with an increased risk of early-onset Alzheimer's disease and a reduced survival. (1995) (41)
- Occupational exposures to solvents and lead as risk factors for Alzheimer's disease: a collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group. (1991) (41)
- The effect of APOE on dementia is not through atherosclerosis: the Rotterdam Study. (1999) (40)
- Large-scale whole-exome sequencing association studies identify rare functional variants influencing serum urate levels (2018) (40)
- Preparing for presymptomatic DNA testing for early onset Alzheimer's disease/cerebral haemorrhage and hereditary Pick disease. (1997) (40)
- &agr;-Adducin Polymorphism, Atherosclerosis, and Cardiovascular and Cerebrovascular Risk (2006) (40)
- Eight-fold increased risk for congenital heart defects in children carrying the nicotinamide N-methyltransferase polymorphism and exposed to medicines and low nicotinamide. (2008) (40)
- Smoking-dependent effects of the angiotensin-converting enzyme gene insertion/deletion polymorphism on blood pressure (2004) (40)
- Alzheimer’s Disease: Genes, Pathogenesis and Risk Prediction (2001) (40)
- Insulin-like growth factor-I gene polymorphism and risk of heart failure (the Rotterdam Study). (2004) (40)
- Dominant hemochromatosis due to N144H mutation of SLC11A3: clinical and biological characteristics. (2002) (40)
- A population-based study of familial Alzheimer disease: linkage to chromosomes 14, 19, and 21. (1994) (40)
- Prediction of male-pattern baldness from genotypes (2015) (39)
- Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis (2016) (39)
- Large common deletions associate with mortality at old age. (2011) (39)
- Correction: Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution (2009) (39)
- DNA methylation signatures of educational attainment (2018) (39)
- The -1997 G/T and Sp1 Polymorphisms in the Collagen Type I alpha1 (COLIA1) Gene in Relation to Changes in Femoral Neck Bone Mineral Density and the Risk of Fracture in the Elderly: The Rotterdam Study (2007) (39)
- Genetic transmission of Alzheimer's disease among families in a Dutch population based study. (1993) (38)
- Heritability estimates for 361 blood metabolites across 40 genome-wide association studies (2020) (38)
- Association between apolipoprotein-ε4 and long-term outcome after traumatic brain injury (2007) (38)
- Genome-wide study links MTMR7 gene to variant Creutzfeldt-Jakob risk (2012) (38)
- A study of the SORL1 gene in Alzheimer's disease and cognitive function. (2009) (38)
- Two MTHFR polymorphisms, maternal B-vitamin intake, and CHDs. (2008) (38)
- Myocilin mutations in a population-based sample of cases with open-angle glaucoma: the Rotterdam Study (2002) (38)
- Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans (2016) (37)
- Genetic and environmental factors in Alzheimer's disease. (1999) (37)
- Genetic risk factors for cerebral small-vessel disease in hypertensive patients from a genetically isolated population (2010) (37)
- A genome-wide association meta-analysis of plasma Aβ peptides concentrations in the elderly (2014) (37)
- Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry. (2019) (37)
- ApoE Gene Polymorphisms, BMD, and Fracture Risk in Elderly Men and Women: The Rotterdam Study (2004) (37)
- Strengthening the reporting of genetic risk prediction studies: the GRIPS statement. (2011) (37)
- Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (2016) (37)
- Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6 (2018) (37)
- Genetic epidemiology of Alzheimer disease. (1997) (36)
- Gene co-expression analysis identifies brain regions and cell types involved in migraine pathophysiology: a GWAS-based study using the Allen Human Brain Atlas (2016) (36)
- Identification of a candidate gene for astigmatism. (2013) (36)
- Genome-Based Prediction of Breast Cancer Risk in the General Population: A Modeling Study Based on Meta-Analyses of Genetic Associations (2011) (36)
- International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents (2016) (36)
- Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants in Human Hematopoiesis. (2016) (36)
- Common variants in Mendelian kidney disease genes and their association with renal function. (2013) (35)
- Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus (2013) (35)
- Lack of association of two common polymorphisms on 9p21 with risk of coronary heart disease and myocardial infarction; results from a prospective cohort study (2008) (35)
- Fifteen Genetic Loci Associated With the Electrocardiographic P Wave (2017) (35)
- Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug–metabolite atlas (2020) (34)
- Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants. (2014) (34)
- Heterogeneity of the genetic risk in age-related macular disease: a population-based familial risk study. (2005) (34)
- Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels (2016) (34)
- A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol (2011) (34)
- No association between the alpha 1‐antichymotrypsin A allele and Alzheimer's disease (1997) (34)
- The sex-specific associations of the aromatase gene with Alzheimer’s disease and its interaction with IL10 in the Epistasis Project (2013) (34)
- Plasma amino acids and neopterin in healthy persons with Down’s syndrome (2007) (34)
- The relationship between fertility and lifespan in humans (2011) (34)
- A genome-wide search for genes involved in type 2 diabetes in a recently genetically isolated population from the Netherlands. (2003) (34)
- Genetics of the human metabolome, what is next? (2014) (33)
- Pathologically confirmed autoimmune encephalitis in suspected Creutzfeldt-Jakob disease (2015) (33)
- Clinical implications of old and new genes for open-angle glaucoma. (2011) (33)
- Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk (2018) (33)
- Mutations in the Hemochromatosis Gene (HFE) and Stroke (2002) (33)
- Rate of progression of Alzheimer's disease is associated with genetic risk. (1995) (33)
- Variations in estrogen receptor alpha gene and risk of dementia, and brain volumes on MRI. (2004) (32)
- Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects (2019) (32)
- The effect of catechol-O-methyltransferase Met/Val functional polymorphism on smoking cessation: retrospective and prospective analyses in a cohort study (2009) (32)
- Integrating metabolomics, genomics and disease pathways in age-related macular degeneration: The EYE-RISK Consortium. (2020) (32)
- Differential Roles of Angiotensinogen and Angiotensin Receptor type 1 Polymorphisms in Breast Cancer Risk (2007) (32)
- Human transmissible spongiform encephalopathies in eleven countries: diagnostic pattern across time, 1993–2002 (2006) (32)
- Haplotype analyses of the APOA5 gene in patients with familial combined hyperlipidemia. (2007) (32)
- Heritabilities, apolipoprotein E, and effects of inbreeding on plasma lipids in a genetically isolated population: The Erasmus Rucphen Family Study (2007) (32)
- Novel strategy to identify genetic risk factors for COPD severity: a genetic isolate (2009) (32)
- Creutzfeldt-Jakob disease 38 years after diagnostic use of human growth hormone (2002) (32)
- Genetic factors and insulin secretion: gene variants in the IGF genes. (2004) (32)
- Genome-wide association study of primary open-angle glaucoma in continental and admixed African populations (2018) (32)
- Plasma Amyloid-β Levels, Cerebral Small Vessel Disease, and Cognition: The Rotterdam Study. (2017) (32)
- Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis (2019) (31)
- A study of familial aggregation of depression, dementia and Parkinson's disease (2004) (31)
- Haplotype reference consortium panel: Practical implications of imputations with large reference panels (2017) (31)
- Region-Based Association Analysis of Human Quantitative Traits in Related Individuals (2013) (31)
- Genome-Wide Profiling of Blood Pressure in Adults and Children (2012) (31)
- Whole genome sequencing of Caribbean Hispanic families with late‐onset Alzheimer's disease (2018) (31)
- Serum MHPG strongly predicts conversion to Alzheimer's disease in behaviorally characterized subjects with Down syndrome. (2014) (31)
- The interleukin-6 –174 G/C promoter polymorphism and arterial stiffness; the Rotterdam Study (2008) (31)
- Source of Variant Creutzfeldt-Jakob Disease outside United Kingdom (2007) (31)
- Loss of DPP6 in neurodegenerative dementia: a genetic player in the dysfunction of neuronal excitability (2019) (31)
- A Methodological Perspective on Genetic Risk Prediction Studies in Type 2 Diabetes: Recommendations for Future Research (2011) (31)
- Estrogen receptor alpha gene polymorphisms associated with incident aging macula disorder. (2007) (30)
- N-acetyltransferase-2 polymorphism in Parkinson’s disease: the Rotterdam study (1999) (30)
- Exome-sequencing in a large population-based study reveals a rare Asn396Ser variant in the LIPG gene associated with depressive symptoms (2017) (30)
- Genome-wide association study for acute otitis media in children identifies FNDC1 as disease contributing gene (2016) (30)
- A Mendelian Randomization Study of Metabolite Profiles, Fasting Glucose, and Type 2 Diabetes (2017) (30)
- Strengthening the Reporting of Genetic Risk Prediction Studies: The GRIPS Statement (2011) (30)
- Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine (2019) (30)
- Family score as an indicator of genetic risk of primary open-angle glaucoma. (2002) (30)
- Whole-Exome Sequencing in Age-Related Macular Degeneration Identifies Rare Variants in COL8A1, a Component of Bruch’s Membrane (2018) (30)
- Familial clustering of multiple sclerosis in a Dutch genetic isolate (2007) (30)
- An R package "VariABEL" for genome-wide searching of potentially interacting loci by testing genotypic variance heterogeneity (2012) (29)
- Amyloid beta secretase gene (BACE) is neither mutated in nor associated with early-onset Alzheimer's disease. (2001) (29)
- Assessment of the 9p21.3 locus in severity of coronary artery disease in the presence and absence of type 2 diabetes (2013) (29)
- Discovery of novel heart rate-associated loci using the Exome Chip (2017) (29)
- Parental family history of dementia in relation to subclinical brain disease and dementia risk (2017) (29)
- Maternal medication use, carriership of the ABCB1 3435C > T polymorphism and the risk of a child with cleft lip with or without cleft palate (2009) (29)
- Interaction between the Gly460Trp α-adducin gene variant and diuretics on the risk of myocardial infarction (2009) (29)
- Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour (2021) (29)
- A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine (2020) (29)
- Gut Microbiota Composition Is Related to AD Pathology (2022) (28)
- Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype. (2019) (28)
- Determinants of DNA yield and purity collected with buccal cell samples (2009) (28)
- Detecting Low Frequent Loss-of-Function Alleles in Genome Wide Association Studies with Red Hair Color as Example (2011) (28)
- Interactions between dietary vitamin E intake and SIRT1 genetic variation influence body mass index. (2010) (28)
- A promoter polymorphism of the insulin-like growth factor-I gene is associated with left ventricular hypertrophy (2005) (28)
- Susceptibility to Chronic Mucus Hypersecretion, a Genome Wide Association Study (2011) (28)
- Genetic Loci for Retinal Arteriolar Microcirculation (2013) (28)
- A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. (2019) (28)
- Genetic Scoring Analysis: a way forward in Genome Wide Association Studies? (2009) (28)
- Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium (2014) (28)
- Beyond public health genomics: proposals from an international working group (2014) (28)
- The influence of the alpha-adducin G460W polymorphism and angiotensinogen M235T polymorphism on antihypertensive medication and blood pressure (2006) (28)
- The ACE insertion/deletion polymorphism and risk of cancer, a review and meta-analysis of the literature. (2011) (28)
- Glucocorticoid receptor-9beta polymorphism is associated with systolic blood pressure and heart growth during early childhood. The Generation R Study. (2011) (28)
- Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval (2013) (27)
- The cystatin C polymorphism is not associated with early onset Alzheimer’s disease (2001) (27)
- Accuracy of self-reported family history is strongly influenced by the accuracy of self-reported personal health status of relatives. (2012) (26)
- The H63D variant in the HFE gene predisposes to arthralgia, chondrocalcinosis and osteoarthritis (2007) (26)
- Associations with intraocular pressure across Europe: The European Eye Epidemiology (E3) Consortium (2015) (26)
- Stroke genetics informs drug discovery and risk prediction across ancestries (2022) (26)
- Bivariate Genome-Wide Association Study of Depressive Symptoms With Type 2 Diabetes and Quantitative Glycemic Traits (2017) (26)
- Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes (2018) (26)
- In search of genes involved in neurodegenerative disorders. (2005) (26)
- The genetic epidemiology of glioma (2001) (26)
- Genetic Loci for Coronary Calcification and Serum Lipids Relate to Aortic and Carotid Calcification (2013) (26)
- Transforming-growth factor beta1 Leu10Pro polymorphism and breast cancer morbidity. (2007) (26)
- Association of HSP70 and its co-chaperones with Alzheimer's disease. (2011) (26)
- GWAS and Meta-Analysis in Aging/Longevity. (2015) (26)
- Antipsychotic-Induced Movement Disorders in Long-Stay Psychiatric Patients and 45 Tag SNPs in 7 Candidate Genes: A Prospective Study (2012) (26)
- The Rationale and Design of the Perindopril Genetic Association Study (PERGENE): A Pharmacogenetic Analysis of Angiotensin-Converting Enzyme Inhibitor Therapy in Patients with Stable Coronary Artery Disease (2009) (26)
- Prediction of febrile seizures in siblings: a practical approach (1998) (26)
- Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) (26)
- A Genome Wide Association Study Links Glutamate Receptor Pathway to Sporadic Creutzfeldt-Jakob Disease Risk (2015) (26)
- Adherence to and dosing of beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitors in the general population differs according to apolipoprotein E-genotypes. (2003) (26)
- Apolipoprotein E4 in the temporal variant of frontotemporal dementia (2002) (26)
- Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume (2018) (26)
- An insulin-like growth factor-I promoter polymorphism is associated with increased mortality in subjects with myocardial infarction in an elderly Caucasian population. (2006) (26)
- Harmonising and linking biomedical and clinical data across disparate data archives to enable integrative cross-biobank research (2015) (26)
- Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits (2019) (26)
- Angiotensinogen Promoter B-Haplotype Associated With Cerebral Small Vessel Disease Enhances Basal Transcriptional Activity (2004) (26)
- Association of common genetic variants with brain microbleeds (2020) (25)
- A novel presenilin 1 mutation (L174 M) in a large Cuban family with early onset Alzheimer disease (2002) (25)
- Health professions and risk of sporadic Creutzfeldt-Jakob disease, 1965 to 2010. (2012) (25)
- Epistatic effect of cholesteryl ester transfer protein and hepatic lipase on serum high-density lipoprotein cholesterol levels. (2007) (25)
- Predictive value of multiple genetic testing for age-related macular degeneration. (2007) (25)
- Rare Genetic Variant in SORL1 May Increase Penetrance of Alzheimer’s Disease in a Family with Several Generations of APOE-ɛ4 Homozygosity (2016) (25)
- Effect of the APOE-491A/T promoter polymorphism on apolipoprotein E levels and risk of Alzheimer disease: The Rotterdam Study. (2002) (25)
- Candidate Gene-Based Association Study of Antipsychotic-Induced Movement Disorders in Long-Stay Psychiatric Patients: A Prospective Study (2012) (25)
- Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants in Human Hematopoiesis. (2016) (25)
- Evidence for Allelic Heterogeneity in Familial Early-Onset Alzheimer's Disease (1991) (25)
- Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer’s Disease Sequencing Project (2018) (25)
- Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer’s disease (2018) (24)
- Constant Transmission Properties of Variant Creutzfeldt-Jakob Disease in 5 Countries (2012) (24)
- Variation in the IGF1 gene and growth in foetal life and infancy. The Generation R Study (2008) (24)
- Genome-wide association study in almost 195,000 individuals identifies 50 previously unidentified genetic loci for eye color (2021) (24)
- Risk of Left Ventricular Dysfunction in Patients with Probable Alzheimer's Disease with APOE*4 Allele (1998) (24)
- Drug-Gene Interactions between Genetic Polymorphisms and Antihypertensive Therapy (2004) (24)
- Smoking-by-genotype interaction in type 2 diabetes risk and fasting glucose (2020) (24)
- A Genome-Wide Screen for Depression in Two Independent Dutch Populations (2010) (24)
- The association between angiotensin-converting enzyme gene polymorphism and coronary calcification. The Rotterdam Coronary Calcification Study. (2005) (24)
- An IGF-I Gene Polymorphism Modifies the Risk of Diabetic Retinopathy (2006) (24)
- Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting (2019) (24)
- ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals (2018) (24)
- A polymorphism in the regulatory region of PRNP is associated with increased risk of sporadic Creutzfeldt-Jakob disease (2011) (23)
- Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache (2020) (23)
- Novel Genetic Loci Associated With Retinal Microvascular Diameter (2016) (23)
- Genetic architecture of open angle glaucoma and related determinants (2010) (23)
- Metabolic profiling of intra- and extracranial carotid artery atherosclerosis. (2018) (23)
- The cholesteryl ester transfer protein I405V polymorphism is associated with increased high-density lipoprotein levels and decreased risk of myocardial infarction: the Rotterdam Study (2007) (23)
- Interactions between PPAR-α and inflammation-related cytokine genes on the development of Alzheimer's disease, observed by the Epistasis Project. (2012) (23)
- The ERCC6 Gene and Age-Related Macular Degeneration (2010) (23)
- Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images (2020) (23)
- Association between Type 2 Diabetes Loci and Measures of Fatness (2010) (23)
- The risk of myocardial infarction in patients with reduced activity of cytochrome P450 2C9 (2007) (23)
- Space-time clustering patterns of gliomas in The Netherlands suggest an infectious aetiology. (2005) (23)
- Plasma levels of nitric oxide related amino acids in demented subjects with Down syndrome are related to neopterin concentrations (2009) (23)
- Non-additive genome-wide association scan reveals a new gene associated with habitual coffee consumption (2016) (22)
- Narrow-sense heritability estimation of complex traits using identity-by-descent information (2017) (22)
- Twenty-eight genetic loci associated with ST-T-wave amplitudes of the electrocardiogram (2016) (22)
- Is genetic screening for hemochromatosis worthwhile? (2003) (22)
- Heritabilities, proportions of heritabilities explained by GWAS findings, and implications of cross-phenotype effects on PR interval (2015) (22)
- Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration (2011) (22)
- Pharmacoeconomic evaluation of testing for angiotensin-converting enzyme genotype before starting beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitor therapy in men. (2004) (22)
- Common variants at 12q15 and 12q24 are associated with infant head circumference (2013) (22)
- Insulin-like growth factor-I receptor stimulating activity is associated with dementia. (2014) (22)
- Association of an APOC3 promoter variant with type 2 diabetes risk and need for insulin treatment in lean persons (2011) (22)
- Heritability of dietary food intake patterns (2012) (22)
- A Genome-Wide Scan for MicroRNA-Related Genetic Variants Associated With Primary Open-Angle Glaucoma (2017) (22)
- A systematic evaluation of 151 candidate genes for their association with osteoporosis and osteoporotic fracture in a meta-analysis of genome-wide association data (2009) (22)
- Genetic Testing Has No Place as a Routine Diagnostic Test in Sporadic and Familial Cases of Alzheimer's Disease (2004) (21)
- An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene‐Lifestyle Interactions Working Group (2016) (21)
- Genetic architecture of circulating lipid levels (2011) (21)
- Evidence for a role of the genomic region of the gene encoding for the alpha1 chain of type IX collagen (COL9A1) in hip osteoarthritis: A population-based study. (2005) (21)
- The role of hemochromatosis C282Y and H63D gene mutations in type 2 diabetes: findings from the Rotterdam Study and meta-analysis. (2002) (21)
- Exome-sequencing in a large population-based study reveals a rare Asn396Ser variant in the LIPG gene associated with depressive symptoms (2017) (21)
- White Matter Lesion Progression: Genome-Wide Search for Genetic Influences (2015) (21)
- A linear mixed-model approach to study multivariate gene–environment interactions (2018) (21)
- Interleukin 6 G−174 C polymorphism and breast cancer risk (2006) (21)
- The effectiveness of hydroxy-methylglutaryl coenzyme A reductase inhibitors (statins) in the elderly is not influenced by apolipoprotein E genotype. (2002) (21)
- Heritability and Genome-Wide Association Analyses of Human Gait Suggest Contribution of Common Variants. (2016) (20)
- Blood Metabolomic Measures Associate With Present and Future Glycemic Control in Type 2 Diabetes (2018) (20)
- Effectiveness of HMG-CoA reductase inhibitors is modified by the ACE insertion deletion polymorphism. (2004) (20)
- HASE: Framework for efficient high-dimensional association analyses (2016) (20)
- Revisiting the Role of Insulin-Like Growth Factor-I Receptor Stimulating Activity and the Apolipoprotein E in Alzheimer’s Disease (2019) (20)
- Evaluation of the Myocilin Mutation Gln368Stop Demonstrates Reduced Penetrance for Glaucoma in European Populations. (2017) (20)
- Search for Early Pancreatic Cancer Blood Biomarkers in Five European Prospective Population Biobanks Using Metabolomics (2019) (20)
- Shared genetic factors in the co-occurrence of symptoms of depression and cardiovascular risk factors. (2010) (20)
- Hypertension as a risk factor for glioma? Evidence from a population-based study of comorbidity in glioma patients. (2004) (20)
- COPD GWAS variant at 19q13.2 in relation with DNA methylation and gene expression (2017) (20)
- Metabolic Age Based on the BBMRI-NL 1H-NMR Metabolomics Repository as Biomarker of Age-related Disease (2020) (20)
- Insulin gene variable number of tandem repeats is not associated with weight from fetal life until infancy: the Generation R Study. (2007) (19)
- Hypothesis-free identification of modulators of genetic risk factors (2015) (19)
- Breast-Feeding Modifies the Association of PPARγ2 Polymorphism Pro12Ala With Growth in Early Life (2009) (19)
- Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease (2018) (19)
- IGF-I gene promoter polymorphism is a predictor of survival after myocardial infarction in patients with type 2 diabetes. (2006) (19)
- Interaction of insulin and PPAR-α genes in Alzheimer’s disease: the Epistasis Project (2012) (19)
- STrengthening the REporting of Genetic Association studies (STREGA): an extension of the STROBE Statement. (2009) (19)
- Delirium in the acute phase after stroke and the role of the apolipoprotein E gene. (2013) (19)
- Modifiable risk factors for dementia and dementia risk profiling. A user manual for Brain Health Services—part 2 of 6 (2021) (19)
- Translational research in genomics of Alzheimer's disease: a review of current practice and future perspectives. (2010) (19)
- Heritability and Genome-Wide Association Analyses of Intracranial Carotid Artery Calcification: The Rotterdam Study (2016) (19)
- Serum NGAL is Associated with Distinct Plasma Amyloid-β Peptides According to the Clinical Diagnosis of Dementia in Down Syndrome. (2015) (19)
- Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology. (2019) (19)
- Perspectives on the Use of Multiple Sclerosis Risk Genes for Prediction (2011) (19)
- The alpha2-macroglobulin gene in AD: a population-based study and meta-analysis. (2000) (19)
- Insulin VNTR and IGF-1 Promoter Region Polymorphisms Are Not Associated with Body Composition in Early Childhood: The Generation R Study (2010) (19)
- Parent-of-Origin Effects of the APOB Gene on Adiposity in Young Adults (2015) (18)
- Role of shared genetic and environmental factors in symptoms of depression and body composition (2009) (18)
- Large-scale Meta-analysis of Genome-wide Association (GWA) Scans for Osteoporosis Traits: the GEFOS Consortium (2008) (18)
- Hormone replacement therapy and Alzheimer's disease. (1999) (18)
- Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval (2018) (18)
- Integrating metabolomics profiling measurements across multiple biobanks. (2014) (18)
- Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error (2020) (18)
- A genome-wide association study identifies genetic loci associated with specific lobar brain volumes (2019) (18)
- Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS (2022) (18)
- Understanding the role of the chromosome 15q25.1 in COPD through epigenetics and transcriptomics (2018) (17)
- Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (2018) (17)
- Rare genetic variation implicated in non-Hispanic white families with Alzheimer disease (2018) (17)
- Association of Circulating Metabolites in Plasma or Serum and Risk of Stroke (2020) (17)
- Strengthening the reporting of genetic risk prediction studies: the GRIPS statement (2011) (17)
- Pharmacogenetic interactions of three candidate gene polymorphisms with ACE-inhibitors or beta-blockers and the risk of atherosclerosis. (2007) (17)
- Effects of the Renin-Angiotensin System Genes and Salt Sensitivity Genes on Blood Pressure and Atherosclerosis in the Total Population and Patients With Type 2 Diabetes (2007) (17)
- TGF-beta1 polymorphisms and arterial stiffness; the Rotterdam Study. (2007) (17)
- HFE gene mutations increase the risk of coronary heart disease in women (2010) (17)
- Drug-Gene Interaction Between the Insertion/Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Antihypertensive Therapy (2006) (17)
- Identifying genetic risk variants for coronary heart disease in familial hypercholesterolemia: an extreme genetics approach (2014) (16)
- Reversal of Aging‐Induced Increases in Aortic Stiffness by Targeting Cytoskeletal Protein‐Protein Interfaces (2018) (16)
- Genetic Variation in the Renin-Angiotensin System and Arterial Stiffness. The Rotterdam Study (2009) (16)
- Development and Application of Genomic Control Methods for Genome-Wide Association Studies Using Non-Additive Models (2013) (16)
- Evaluation of Presumably Disease Causing SCN1A Variants in a Cohort of Common Epilepsy Syndromes (2016) (16)
- Direct-to-consumer personal genome testing for age-related macular degeneration. (2014) (16)
- No association between the angiotensin-converting enzyme gene and major depression: a case-control study and meta-analysis. (2006) (16)
- Longevity candidate genes and their association with personality traits in the elderly (2012) (16)
- CYP2D6 polymorphism in Parkinson's disease: The Rotterdam study (2001) (15)
- Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease. (2022) (15)
- Genetic Factors Influence the Clustering of Depression among Individuals with Lower Socioeconomic Status (2009) (15)
- Association Analysis of Ten Candidate Genes in a Large Multinational Cohort of Small for Gestational Age Children and Children with Idiopathic Short Stature (NESTEGG study) (2013) (15)
- Three VCP Mutations in Patients with Frontotemporal Dementia. (2018) (15)
- Genetic variation in the fibrinogen-α and fibrinogen-γ genes in relation to arterial stiffness: the Rotterdam Study (2009) (15)
- Suggestive linkage to chromosome 19 in a large Cuban family with late‐onset Parkinson's disease (2003) (15)
- Identification of Srp9 as a febrile seizure susceptibility gene (2014) (15)
- Type 2 diabetes gene TCF7L2 polymorphism is not associated with fetal and postnatal growth in two birth cohort studies (2009) (15)
- Genetic testing should not be advocated as a diagnostic tool in familial forms of dementia. (2000) (15)
- Quality control and integration of genotypes from two calling pipelines for whole genome sequence data in the Alzheimer's disease sequencing project. (2019) (15)
- IGF-1 CA repeat variant and breast cancer risk in postmenopausal women. (2007) (15)
- Variable expression of presenilin 1 is not a major determinant of risk for late-onset Alzheimer's Disease (2001) (14)
- Apolipoprotein E gene is related to mortality only in normal weight individuals: The Rotterdam study (2007) (14)
- Gut microbiome-wide association study of depressive symptoms (2022) (14)
- Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention (2022) (14)
- Angiotensinogen M235T polymorphism and symptoms of depression in a population-based study and a family-based study (2008) (14)
- No evidence for association between tau gene haplotypic variants and susceptibility to Creutzfeldt-Jakob disease (2007) (14)
- A characterization of cis- and trans-heritability of RNA-Seq-based gene expression (2019) (14)
- Genetic analysis of over one million people identifies 535 novel loci for blood pressure (2017) (14)
- Linkage analysis and whole exome sequencing identify a novel candidate gene in a Dutch multiple sclerosis family (2018) (14)
- Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation (2018) (14)
- Characteristics of the initial seizure in familial febrile seizures (1999) (14)
- Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity (2020) (14)
- Genome-wide identification of directed gene networks using large-scale population genomics data (2017) (14)
- The α-Adducin Gene Is Associated With Macrovascular Complications and Mortality in Patients With Type 2 Diabetes (2006) (14)
- An insulin-like growth factor-I gene polymorphism modifies the risk of microalbuminuria in subjects with an abnormal glucose tolerance. (2006) (14)
- Age at onset of genetic (E200K) and sporadic Creutzfeldt-Jakob diseases is modulated by the CYP4X1 gene (2018) (13)
- Automated workflow-based exploitation of pathway databases provides new insights into genetic associations of metabolite profiles (2013) (13)
- Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk (2020) (13)
- An empirical comparison of meta-analyses of published gene-disease associations versus consortium analyses (2009) (13)
- Prospective study of insulin-like growth factor-I, insulin-like growth factor-binding protein 3, genetic variants in the IGF1 and IGFBP3 genes and risk of coronary artery disease. (2011) (13)
- REVIEW: Prospects of genetic epidemiology in the 21st century (2002) (13)
- Exome Chip Analysis Identifies Low-Frequency and Rare Variants in MRPL38 for White Matter Hyperintensities on Brain Magnetic Resonance Imaging (2018) (13)
- A critical appraisal of epidemiological studies comes from basic knowledge: a reader's guide to assess potential for biases (2007) (13)
- Agreement between oral contraceptive users and prescribers: implications for case-control studies. (1992) (13)
- The first two patients with dura mater associated Creutzfeldt-Jakob disease in the Netherlands (2001) (12)
- Heritability and genome-wide associations studies of cerebral blood flow in the general population (2017) (12)
- Lipoprotein receptor-related protein 1 variants and dietary fatty acids: meta-analysis of European origin and African American studies (2013) (12)
- Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes (2019) (12)
- No association of obesity gene FTO with body composition at the age of 6 months. The Generation R Study (2011) (12)
- Score test for familial aggregation in probands studies: application to Alzheimer's disease. (1995) (12)
- Effectiveness of statins in the reduction of the risk of myocardial infarction is modified by the GNB3 C825T variant (2008) (12)
- Interleukin-1 gene cluster variants with innate cytokine production profiles and osteoarthritis in subjects from the Genetics, Osteoarthritis and Progression Study. (2010) (12)
- Cathepsin D (C224T) Polymorphism in Sporadic and Genetic Creutzfeldt-Jakob Disease (2010) (12)
- Genetic loci for serum lipid fractions and intracerebral hemorrhage. (2016) (12)
- Insertion/deletion gene polymorphism of the angiotensin-converting enzyme and blood pressure changes in older adults. The Rotterdam study (2007) (12)
- The hemochromatosis N144H mutation of SLC11A3 gene in patients with type 2 diabetes. (2002) (12)
- The Challenges of Genome-Wide Interaction Studies: Lessons to Learn from the Analysis of HDL Blood Levels (2014) (12)
- Genetics of human gut microbiome composition (2020) (12)
- Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome‐wide association study in over 12,000 non‐demented participants (2021) (12)
- Genetic risk of Parkinson's disease in the general population. (2016) (12)
- Genetic Determinants of Unruptured Intracranial Aneurysms in the General Population (2015) (11)
- Genetic African Ancestry Is Associated With Central Corneal Thickness and Intraocular Pressure in Primary Open-Angle Glaucoma. (2017) (11)
- Reasons for non‐response in observational pharmacogenetic research (2009) (11)
- A variant of the IGF-I gene is associated with blood pressure but not with left heart dimensions at the age of 2 years: the Generation R Study. (2008) (11)
- The Epistasis Project: A Multi-Cohort Study of the Effects of BDNF, DBH, and SORT1 Epistasis on Alzheimer's Disease Risk. (2019) (11)
- Fast LC-ESI-MS/MS analysis and influence of sampling conditions for gut metabolites in plasma and serum (2019) (11)
- Runs of Homozygosity Do Not Influence Survival to Old Age (2011) (11)
- Associations of NINJ2 Sequence Variants with Incident Ischemic Stroke in the Cohorts for Heart and Aging in Genomic Epidemiology (CHARGE) Consortium (2014) (11)
- BSE and variant Creutzfeldt-Jakob disease: never say never (2002) (11)
- The association between antihypertensive drugs and glioma (2006) (11)
- Impact of cumulative SBP and serious adverse events on efficacy of intensive blood pressure treatment: a randomized clinical trial (2019) (11)
- Genetic Determinants of Electrocardiographic P-Wave Duration and Relation to Atrial Fibrillation (2020) (10)
- DNA methylation is associated with lung function in never smokers (2019) (10)
- Genetic variation in the renin—angiotensin system, use of renin—angiotensin system inhibitors and the risk of myocardial infarction (2011) (10)
- Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium (2012) (10)
- Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2018) (10)
- A large cross-ancestry meta-analysis of genome-wide association studies identifies 69 novel risk loci for primary open-angle glaucoma and includes a genetic link with Alzheimer’s disease (2020) (10)
- Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers (2022) (10)
- Bone Mineral Density in Sjögren Syndrome Patients with and Without Distal Renal Tubular Acidosis (2016) (10)
- Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche DTU Orbit (05/11/2017) (2014) (10)
- Commentary: A polymorphic CA repeat in the promoter region of the insulin-like growth factor I (IGF-I) gene (2002) (10)
- A genetic epidemiologic study of candidate genes involved in the optic nerve head morphology. (2012) (10)
- Insertion/deletion polymorphism of the ACE gene and adherence to ACE inhibitors. (2005) (10)
- Strengthening the reporting of Genetic Risk Prediction Studies: the GRIPS statement. (2011) (10)
- Association of lysophosphatidic acids with cerebrospinal fluid biomarkers and progression to Alzheimer’s disease (2020) (10)
- Gray matter heritability in family‐based and population‐based studies using voxel‐based morphometry (2017) (9)
- Editorial: Good prospects for genetic and molecular epidemiologic studies in the European Journal of Epidemiology (2002) (9)
- A cross-omics integrative study of metabolic signatures of chronic obstructive pulmonary disease (2020) (9)
- Role of APOE in Dementia:A Critical Reappraisal (1998) (9)
- Association of heat shock proteins with Parkinson’s disease (2011) (9)
- Multi-ancestry genome-wide gene–sleep interactions identify novel loci for blood pressure (2021) (9)
- Multiomics integrative analysis identifies APOE allele-specific blood biomarkers associated to Alzheimer’s disease etiopathogenesis (2021) (9)
- Correction: Four Novel Loci (19q13, 6q24, 12q24, and 5q14) Influence the Microcirculation In Vivo (2010) (9)
- A common haplotype lowers SPI1 (PU.1) expression in myeloid cells and delays age at onset for Alzheimer’s disease (2017) (9)
- Correction: Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults (2017) (9)
- Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders (2017) (9)
- Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci (2020) (9)
- Strengthening the reporting of Genetic RIsk Prediction Studies: the GRIPS Statement. (2011) (9)
- Scientific reporting is suboptimal for aspects that characterize genetic risk prediction studies: a review of published articles based on the Genetic RIsk Prediction Studies statement. (2014) (9)
- Value of the HLA-DRB1 shared epitope for predicting radiographic damage in rheumatoid arthritis depends on the individual patient risk profile. (2006) (9)
- Twenty loci associated with bone mineral density identified by large-scale meta-analysis of genome-wide association datasets (2009) (8)
- Measurement and genetic architecture of lifetime depression in the Netherlands as assessed by LIDAS (Lifetime Depression Assessment Self-report) (2020) (8)
- A Genome-Wide Linkage Study for Chronic Obstructive Pulmonary Disease in a Dutch Genetic Isolate Identifies Novel Rare Candidate Variants (2018) (8)
- A large-scale population-based analysis of common genetic variation in the thyroid hormone receptor alpha locus and bone. (2012) (8)
- Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass (2017) (8)
- Determining Possible Shared Genetic Architecture Between Myopia and Primary Open-Angle Glaucoma (2019) (8)
- Decreased sensitivity to dexamethasone in lymphocytes from patients with Alzheimer's disease. (1994) (8)
- Association of Diabetes Medication With Open-Angle Glaucoma, Age-Related Macular Degeneration, and Cataract in the Rotterdam Study. (2022) (8)
- Linkage analysis for plasma amyloid beta levels in persons with hypertension implicates Aβ-40 levels to presenilin 2 (2012) (8)
- Burden of genetic risk variants in multiple sclerosis families in the Netherlands (2016) (8)
- Strengthening the reporting of genetic risk prediction studies: the GRIPS statement (2011) (8)
- Evidence for novel loci for late-onset Parkinson’s disease in a genetic isolate from the Netherlands (2006) (7)
- Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function (2019) (7)
- Discovering patterns of pleiotropy in genome-wide association studies (2018) (7)
- Strengthening the reporting of genetic risk prediction studies: the GRIPS statement (2011) (7)
- Patients with an ApoE ϵ4 allele require lower doses of coumarin anticoagulants (2005) (7)
- No association of obesity gene FTO with body composition at the age of 6 months. The Generation R Study. (2011) (7)
- Plasma beta amyloid and impaired CO2-induced cerebral vasomotor reactivity. (2007) (7)
- A case-control study of apolipoprotein E genotypes in Alzheimer's disease associated with Down's syndrome. Dutch Study Group on Down's Syndrome and Ageing. (1995) (7)
- Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium (2019) (7)
- REVIEW: Variant Creutzfeldt-Jakob disease (2002) (7)
- Genetic susceptibility to multiple sclerosis: Brain structure and cognitive function in the general population (2017) (7)
- Expression and gene variation studies deny association of human HSD3B1 gene with aldosterone production or blood pressure. (2015) (7)
- Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity (2017) (7)
- A Potential Role for the STXBP5-AS1 Gene in Adult ADHD Symptoms (2019) (7)
- Pharmacogenomics Study of Thiazide Diuretics and QT Interval in Multi-Ethnic Populations: The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) (2017) (7)
- Predicting biological age based on the BBMRI-NL 1H-NMR metabolomics repository (2019) (7)
- Partial derivatives meta-analysis: pooled analyses when individual participant data cannot be shared (2016) (7)
- Exome sequencing identifies three novel AD‐associated genes (2020) (6)
- The Well-Known Gene HHIP and Novel Gene MECR Are Implicated in Small Airway Obstruction. (2016) (6)
- [Eleven years of autopsy on account of Creutzfeldt-Jakob disease in the Netherlands]. (2009) (6)
- The alpha-adducin gene is associated with macrovascular complications and mortality in patients with type 2 diabetes. (2006) (6)
- Menopause and the brain. (1997) (6)
- Predominance of hospital deliveries among children with acute lymphocytic leukemia: speculations about neonatal exposure to fluorescent light (1992) (6)
- A genome-wide association study identifies genetic loci associated with specific lobar brain volumes (2019) (6)
- Apolipoprotein E epsilon4 allele is associated with left ventricular systolic dysfunction. (2004) (6)
- Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals (2019) (6)
- A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids (2021) (6)
- Genome-Wide Meta-Analysis of Late-Onset Alzheimer's Disease Using Rare Variant Imputation in 324,809 Subjects Identifies Novel Rare Variant Locus NCK2: The International Genomics of Alzheimer's Project (IGAP) (2021) (6)
- Strengthening the Reporting of Genetic Risk Prediction Studies: The GRIPS Statement (2011) (6)
- The first case of variant Creutzfeldt-Jakob disease in the Netherlands (2007) (6)
- EIF2AK3 variants in Dutch patients with Alzheimer's disease (2019) (6)
- [Gliomas: the role of environmental risk factors and genetic predisposition]. (2005) (6)
- Interpretation and actionability of genetic variants in cardiomyopathies: a position statement from the European Society of Cardiology Council on cardiovascular genomics. (2022) (6)
- Fine mapping the CETP region reveals a common intronic insertion associated to HDL-C (2015) (6)
- Random glucose GWAS in 493,036 individuals provides insights into diabetes pathophysiology, complications and treatment stratification (2021) (6)
- Infectious mononucleosis-linked HLA class I single nucleotide polymorphism is associated with multiple sclerosis (2010) (6)
- The Role of Gut Microbiota in Neuropsychiatric Diseases – Creation of An Atlas-Based on Quantified Evidence (2022) (6)
- A genetic variant in SLC6A20 is associated with Type 2 diabetes in white‐European and Chinese populations (2014) (5)
- Multicenter cohort association study of SLC2A1 single nucleotide polymorphisms and age-related macular degeneration (2012) (5)
- Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer’s disease (2022) (5)
- Matrix metalloproteinase 10 is linked to the risk of progression to dementia of the Alzheimer's type. (2022) (5)
- A polymorphic CA repeat in the promoter region of the insulin-like growth factor- (2003) (5)
- Genetic transmission ofAlzheimer's disease among families inaDutchpopulation based study (1993) (5)
- Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways (2022) (5)
- Strengthening the reporting of genetic risk prediction studies: the GRIPS statement (2011) (5)
- The TNFRSF6 gene is not implicated in familial early-onset Alzheimer's disease. (2001) (5)
- Opportunities for population-based studies of complex genetic disorders after the human genome project. (2001) (5)
- Genome Wide Association Metanalysis Of Skull Bone Mineral Density Identifies Loci Relevant For Osteoporosis And Craniosynostosis (2021) (5)
- Phenotypic Subtypes in Attention Deficit Hyperactivity Disorder in an Isolated Population (2005) (5)
- Circulating metabolites are associated with brain atrophy and white matter hyperintensities (2020) (5)
- Variation in the IGF‐1 gene is associated with lymphocyte subset counts in neonates: The Generation R Study (2009) (5)
- An Integrated Molecular Atlas of Alzheimer's Disease (2021) (5)
- Variants in STAT5B associate with serum TC and LDL-C levels. (2011) (4)
- A combined linkage, microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy (2018) (4)
- A Combined Linkage and Exome Sequencing Analysis for Electrocardiogram Parameters in the Erasmus Rucphen Family Study (2016) (4)
- Genome-wide association study identifies 48 common genetic variants associated with handedness (2020) (4)
- Genome-wide association study of frontotemporal dementia identifies a C9ORF72 haplotype with a median of 12-G4C2 repeats that predisposes to pathological repeat expansions (2021) (4)
- Insulin-like growth factor-I genotype and birthweight (2002) (4)
- Occupational exposure to gases/fumes and mineral dust affect DNA methylation levels of genes regulating expression (2019) (4)
- Occupational exposure to gases/fumes and mineral dust affect DNA methylation levels of genes regulating expression (2019) (4)
- Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2018) (4)
- Meta-analysis of genome-wide association results in > 10.000 individuals for the big five personality traits (2009) (4)
- Variants in TTC25 affect autistic trait in patients with autism spectrum disorder and general population (2017) (4)
- Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity (2017) (4)
- Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration (2011) (4)
- WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene (2019) (4)
- A multi-omics study of circulating phospholipid markers of blood pressure (2020) (4)
- Strengthening the reporting of Genetic RIsk Prediction Studies (GRIPS): explanation and elaboration. (2011) (4)
- Exome-Wide Meta-Analysis Identifies Rare 3′-UTR Variant in ERCC1/CD3EAP Associated with Symptoms of Sleep Apnea (2017) (4)
- No modification of the beneficial effect of NSAIDs on colorectal cancer by CYP2C9 genotype. (2009) (4)
- Brain Health Services: organization, structure, and challenges for implementation. A user manual for Brain Health Services—part 1 of 6 (2021) (4)
- Plasma Brain-Derived Neurotropic Factor Levels Are Associated with Aging and Smoking But Not with Future Dementia in the Rotterdam Study (2021) (4)
- [Roaming through methodology. XXXVII. Unintentional population stratification in genetic case-control studies]. (2002) (4)
- SIRT1 genetic variation is related to body mass index and risk of obesity Running title: SIRT1 gene variation, BMI, and obesity (2009) (4)
- Polymorphisms in genes within the IGF-axis influence antenatal and postnatal growth (2012) (3)
- Exome Sequencing Analysis Identifies Rare Variants in ATM and RPL8 That Are Associated With Shorter Telomere Length (2020) (3)
- Large meta-analysis of genome-wide association studies identifies five loci for lean body mass (2017) (3)
- A Method for Pooling Alleles from Different Genotyping Experiments (2005) (3)
- A method for pooling alleles from different genotyping experiments. (2005) (3)
- Prion protein codon 129 polymorphism in mild cognitive impairment and dementia: the Rotterdam Study (2020) (3)
- Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure (2020) (3)
- Discovery and functional prioritization of Parkinson’s disease candidate genes from large-scale whole exome sequencing (2017) (3)
- [Human spongiform encephalopathies in the Netherlands]. (2009) (3)
- Genome-wide analysis of constitutional DNA methylation in familial melanoma (2020) (3)
- Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate (2022) (3)
- Alcohol and mortality Results from the EPOZ follow-up study (2003) (3)
- Second probable case of vCJD in the Netherlands. (2006) (3)
- Prospects of genetic research of mild cognitive impairment. (2004) (3)
- [From gene to disease; presenilins and Alzheimer disease]. (2002) (3)
- A novel method for serum lipoprotein profiling using high performance capillary isotachophoresis. (2016) (3)
- A polymorphism in the gene for insulin-like growth factor-I: Functional properties and risk for type 2 diabetes mellitus and myocardial infarction (2000) (2)
- Absence of pathogenic mutations in presenilin homologue 2 in a conclusively 17-linked tau-negative dementia family (2004) (2)
- Whole-Genome Linkage Scan Combined With Exome Sequencing Identifies Novel Candidate Genes for Carotid Intima-Media Thickness (2018) (2)
- [The role of apolipoproteins E genotyping in the differential diagnosis of dementia]. (1996) (2)
- [Creutzfeldt-Jakob disease: diagnosis, incidence, prevention and treatment]. (2002) (2)
- Novel Rare Genetic Variants Associated with Airflow Obstruction in the General Population. (2020) (2)
- Publisher Correction: A meta-analysis of genome-wide association studies identifies multiple longevity genes (2021) (2)
- Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning (2022) (2)
- Publisher Correction: Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability (2019) (2)
- Gene association studies in small for gestational age infants. (2002) (2)
- Interferon gamma receptor 2 gene variants are associated with liver fibrosis in the general population: the Rotterdam Study (2014) (2)
- TheTNFRSF6 gene is not implicated in familial early-onset Alzheimer's disease (2001) (2)
- MIND diet lowers risk of open-angle glaucoma: the Rotterdam Study (2022) (2)
- Genetic variation underlying cognition and its relation with neurological outcomes and brain imaging (2018) (2)
- Correction: Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation (2019) (2)
- Metabolic profile changes in serum of migraine patients detected using 1H-NMR spectroscopy (2021) (2)
- Clostridium shows a higher abundance in less neurovascular and neurodegenerative changes: A microbiome‐wide association study (2020) (2)
- Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney (2017) (2)
- Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids (2019) (2)
- Commentary: Genetic screening for common mutations: Lessons from hereditary hemochromatosis (2003) (2)
- Exome sequencing identifies rare damaging variants in the ATB8B4 and ABCA1 genes as novel risk factors for Alzheimer’s disease (2021) (2)
- INFANT FEEDING AND CHILDHOOD CANCER (1988) (2)
- Genome-wide association study identifies risk variants for sporadic Creutzfeldt-Jakob disease in STX6 and GAL3ST1 (2020) (2)
- Association of low-frequency and rare coding variants with information processing speed (2016) (2)
- Fat metabolism is associated with telomere length in six population-based studies. (2021) (2)
- Novel DNA methylation sites of glucose and insulin homeostasis: an integrative cross-omics analysis (2018) (2)
- Limited overlap in significant hits between genome-wide association studies on two airflow obstruction definitions in the same population (2019) (2)
- Variant Creutzfeldt-Jakob disease. (2003) (2)
- Author Correction: Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases (2019) (2)
- Erratum: Common variants at 6q22 and 17q21 are associated with intracranial volume (2013) (2)
- What Are the Key Gut Microbiota Involved in Neurological Diseases? A Systematic Review (2022) (2)
- Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities (2019) (2)
- Genetic variation in the C-reactive protein gene and arterial stiffness: The Rotterdam Study (2008) (2)
- Independent Multiple Factor Association Analysis for Multiblock Data in Imaging Genetics (2019) (2)
- Meta-analysis of genome-wide association data involving 6,100 adults of European origin identifies common variants associated with fasting glucose levels (2008) (2)
- Reply to Stephan et al. (2008) (2)
- Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the CHARGE Consortium Running title: Morrison et al; Genomic variation and mortality in adults with HF (2009) (2)
- Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability (2021) (1)
- Alzheimer's disease and glaucoma-reply. (2014) (1)
- Alzheimer dementia characterized by amyloid angiopathy and large amyloid core type senile plaques in the APP 692 Ala → Gly mutation (1998) (1)
- Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization (2021) (1)
- Genome‐wide meta‐analysis of late‐onset Alzheimer’s disease using rare variant imputation in 65,602 subjects identifies risk loci with roles in memory, neurodevelopment, and cardiometabolic traits: The international genomics of Alzheimer’s project (IGAP) (2020) (1)
- Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume (2018) (1)
- Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity (2019) (1)
- STROBE-ME too! (2011) (1)
- Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology. (2019) (1)
- University of Groningen A Genome-Wide Screen for Interactions Reveals a New Locus on 4 p 15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol (2011) (1)
- Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits (2017) (1)
- Skewed X-inactivation is common in the general female population (2018) (1)
- Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus (2020) (1)
- Genetic architecture of subcortical brain structures in 38,851 individuals (2019) (1)
- Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits (2019) (1)
- The role of adiposity in cardiometabolic traits (2013) (1)
- The effectiveness of HMG-CoA reductase inhibitors in an elderly population is independent of apolipoprotein E-genotypes (2002) (1)
- Author Correction: Heritability estimates for 361 blood metabolites across 40 genome-wide association studies (2020) (1)
- Effect of inbreeding on type 2 diabetes-related metabolites in a Dutch genetic isolate (2019) (1)
- Adherence to and dosing of statins differs according to apolipoprotein E-genotypes. (2002) (1)
- Correction. Heritability and genome-wide association analyses of intracranial carotid artery calcification: The Rotterdam Study. (2016) (1)
- Ped_Outlier software for automatic identification of within-family outliers (2010) (1)
- PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity (2018) (1)
- ANGIOTENSIN CONVERTING ENZYME INSERTION/DELETION POLYMORPHISM AND RISK OF HEART FAILURE IN HYPERTENSIVE SUBJECTS: P2.215 (2004) (1)
- Author Correction: Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps (2018) (1)
- Re: "Case-control studies of environmental influences in diseases with genetic determinants, with an application to Alzheimer's disease". (1992) (1)
- Epigenetic and integrative cross-omics analyses of cerebral white matter hyperintensities on MRI (2022) (1)
- The genomic architecture of blood metabolites based on a decade of genome-wide analyses (2019) (1)
- STROBE-ME too! (2011) (1)
- Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries (2022) (1)
- Large-scale meta-analysis establishes the association of the ACE indel polymorphism with Alzheimer’s disease (2005) (1)
- Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility (2017) (1)
- Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error (2020) (1)
- Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution (2019) (1)
- Data and script for the GenABEL paper (2016) (1)
- Genome-wide Association Study Links APOEɛ4 and BACE1 Variants with Plasma Amyloid β Levels (2017) (1)
- [The first patient with the new variant of Creutzfeldt-Jakob's disease in The Netherlands]. (2005) (1)
- Quality Control and Integration of Genotypes from Two Calling Pipelines for Whole Genome Sequence Data in the Alzheimer’s Disease Sequencing Project (2018) (1)
- Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6 (2018) (1)
- The role of the gut microbiome in cognitive function and Alzheimer’s disease (2020) (1)
- CHOLESTERYL ESTER TRANSFER PROTEIN GENE AND CORONARY HEART DISEASE MORTALITY: THE ROTTERDAM STUDY (2007) (1)
- Evidence for a Role of the Genomic Region of the Gene Encoding for the 1 Chain of Type IX Collagen (COL9A1) in Hip Osteoarthritis (2005) (1)
- Modifiable risk factors for dementia and dementia risk profiling. A user manual for Brain Health Services—part 2 of 6 (2021) (1)
- Loci influencing blood pressure identified using a cardiovascular gene-centric array (Correction to Ganesh et al. 22 (8): 1663) (2013) (1)
- Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference (2020) (1)
- Causal Effects of Adiposity on Cardiovascular Risk Factors (2015) (1)
- SORL1‐variant carriers in ADES‐ADSP: A higher level of variant pathogenicity associates with earlier age at onset of Alzheimer's disease (2020) (1)
- Modifiable risk factors for dementia and dementia risk profiling. A user manual for Brain Health Services—part 2 of 6 (2021) (1)
- Migraine without aura: genome-wide association analysis identifies several novel susceptibility (2013) (1)
- Dementia prevention in memory clinics: recommendations from the European task force for brain health services (2023) (1)
- methylSCOPA and META-methylSCOPA: software for the analysis and aggregation of epigenome-wide association studies of multiple correlated phenotypes (2019) (1)
- Ethnicity influences risk of dementia in the UK Biobank (2021) (1)
- Genome-wide association meta-analysis of PR interval identifies 47 novel loci associated with atrial and atrioventricular electrical activity (2018) (1)
- The probabilistic model of Alzheimer disease: the amyloid hypothesis revised (2021) (0)
- Reply (1996) (0)
- Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability (2018) (0)
- Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (2018) (0)
- hypertrophygene is associated with left ventricular A promoter polymorphism of the insulin-like growth (2006) (0)
- The involvement of upstream stimulatory factor 1 in Dutch patients with familial combined hyperlipidemias⃞ (2006) (0)
- Contents Vol. 4, 2001 (2002) (0)
- Author Index Suppl. 1, Vol. 11, 1992 (1992) (0)
- Migraine is not associated with enhanced atherosclerosis 7 (2015) (0)
- Disentangling the relationship between apolipoprotein E, cardiovascular disease, COVID‐19, dementia and mortality (2021) (0)
- Metabolomics based markers predict type 2 diabetes in a 14-year follow-up study (2017) (0)
- Employed family-based genetic discovery combining linkage analysis and exome sequencing to identify RCL1 as a novel candidate gene for depression, with independent replication in a population-based cohort (2018) (0)
- Large-scale whole-exome sequencing association studies identify rare functional variants influencing serum urate levels (2018) (0)
- P4-162 Heritability of cognitive function in later adult life in a single extended pedigree (2004) (0)
- The effects of a moderate physical activity intervention on physical fitness and cognition in healthy elderly with low levels of physical activity: a randomized controlled trial (2023) (0)
- O3-02-07 Linkage analysis for AD using amyloid beta 42 levels shows evidence for a novel AD gene on chromosome 19 (2004) (0)
- University of Groningen Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations Demirkan, (2012) (0)
- A catalog of genetic loci associated with kidney function from analyses of a million individuals (2019) (0)
- Subject Index Vol. 4, 2001 (2002) (0)
- The effect of CYP 2 C 19 polymorphism on the pharmacokinetics and acid-inhibitory effects of oral lansoprazole and omeprazole (2002) (0)
- Erratum (2020) (0)
- Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function (2018) (0)
- Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error (2018) (0)
- First participant diagnosed with Creutzfeldt-Jakob disease in the population-based Rotterdam Study was classified with mild cognitive impairment (2021) (0)
- The H63D mutation in the HFE gene predisposes to arthralgia, chondrocalcinosis, and osteoarthritis (2004) (0)
- Type 2 diabetes gene TCF 7 L 2 polymorphism is not associated with fetal and postnatal growth in two birth cohort studies . TCF 7 L 2 and early growth (2009) (0)
- Author and Subject Index (1998) (0)
- Genomewide meta-analysis identifies loci associated with IGF-I and IGEBP-3 levels with impact on age-related traits (vol 15, pg 811, 2016) (2017) (0)
- Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors (2019) (0)
- Standard process-oriented workflow introduces pre-analytical error when used in large study sample batches (2018) (0)
- The long-term relation between physical activity and executive function in the Rotterdam Study (2022) (0)
- Use with Brain Structure and Function and Risk of Dementia and Alzheimer’s Disease: Pooled Analysis from 6 Cohorts (2018) (0)
- Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals (2019) (0)
- The angiotensinogen gene contributes to the genetic variance of depression symptomatology (2005) (0)
- ' s response to reviews Title : Lack of association of two common polymorphisms on 9 p 21 with risk of coronary heart disease and myocardial infarction (2008) (0)
- STREGA Reporting Recommendations, Extended from STROBE Statement (2009) (0)
- Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms (2016) (0)
- Correction (1960) (0)
- GENETICS: ROLE OF RARE AND LOW FREQUENCY VARIANTS IN ALZHEIMER’S DISEASE O3-13-01 WHOLEGENOMESEQUENCINGOFLATE-ONSET ALZHEIMER’S DISEASE PATIENTS FROM GENETIC ISOLATE (2015) (0)
- We-W30:6 The APOAV gene is associated with familial combined hyperlipidemia and dyslipidemia (2006) (0)
- Correction for both common and rare cell types in blood is important to identify genes that correlate with age (2021) (0)
- ALCOHOL AND MORTALITY. (0)
- Exosomes Isolation Tool with nanofluidic concentration device (EXIT) (2018) (0)
- 297 A NON-SYNONYMOUS SNP IN GENE ASSOCIATED WITH SUSCEPTIBILITY TO SYMPTOMATIC OSTEOARTHRITIS (2007) (0)
- Dna Repair Capacity Determines Age-Related Vascular Dysfunction: 5c.01 (2011) (0)
- A framework for the detection of de novo mutations in family-based sequencing data (2016) (0)
- Genome-wide identification of directed gene networks using large-scale population genomics data (2018) (0)
- An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis (2019) (0)
- Genetic studies of birth weight give biological insights into links with adult disease (2016) (0)
- Five genetic variants associated with prostate cancer. (2008) (0)
- Genetic mechanisms of 184 neuro-related proteins in human plasma (2023) (0)
- A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine (2020) (0)
- Insulin-Like Growth Factor-I Receptor Stimulating Activity Is Associated with Dementia (P1.253) (2014) (0)
- UK 10 K Consortium (2019) (0)
- DNA methylation signatures of educational attainment (2018) (0)
- Profiling the metabolome of patients with dementia in the UK Biobank (2021) (0)
- DNA methylation signatures of educational attainment (2018) (0)
- Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes (2019) (0)
- disease : the Rotterdam study N-acetyltransferase-2 polymorphism in Parkinson ' s (1999) (0)
- Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits (2018) (0)
- Genome-wide association study of primary open-angle glaucoma in continental and admixed African populations (2018) (0)
- Causal relationships between migraine and microstructural white matter: a Mendelian randomization study (2023) (0)
- GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes (2018) (0)
- Mo-W13:5 The CETP I405V polymorphism is associated with high density lipoprotein cholesterol levels and decreased risk of myocardial infarction (2006) (0)
- [Familial forms of fronto-temporal dementia]. (1995) (0)
- Original Article Interactions between PPAR-α and inflammation-related cytokine genes on the development of Alzheimer's dis- ease, observed by the Epistasis Project (2012) (0)
- University of Groningen Common Genetic Determinants of Intraocular Pressure and Primary Open-Angle Glaucoma (2012) (0)
- Reply to — Alzheimer's disease and the family effect (1994) (0)
- University of Groningen Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci Tragante, (2014) (0)
- Gut microbiome‐related metabolites in plasma are associated with general cognition (2021) (0)
- A multi-omics study of circulating phospholipid markers of blood pressure (2022) (0)
- Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels (2019) (0)
- Correction: Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses (2016) (0)
- Analysis of individual families implicates noncoding DNA variation and multiple biological pathways in Alzheimer’s disease risk (2020) (0)
- Interplay of Metabolome and Gut Microbiome in Individuals With Major Depressive Disorder vs Control Individuals. (2023) (0)
- Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores (2023) (0)
- Molecular genetic overlap between migraine and major depressive disorder (2018) (0)
- Genome-wide analysis of constitutional DNA methylation in familial melanoma (2020) (0)
- Association of lysophosphatidic acids with cerebrospinal fluid biomarkers and progression to Alzheimer’s disease (2020) (0)
- Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function (2019) (0)
- A combined linkage, microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy (2018) (0)
- Interplay of the human exposome, metabolome and gut microbiome in dementia and major depression (2022) (0)
- Recessive genetic effects on type 2 diabetes-related metabolites in a consanguineous population (2019) (0)
- Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases (2018) (0)
- A new polygenic score for refractive error improves detection of children at risk of high myopia but not the prediction of those at risk of myopic macular degeneration. (2023) (0)
- Correction: Susceptibility to Chronic Mucus Hypersecretion, a Genome Wide Association Study (2015) (0)
- Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease (2023) (0)
- The Deep Dementia Phenotyping (DEMON) Network: A global platform for innovation using data science and artificial intelligence (2022) (0)
- Blood lipids influence DNA methylation in circulating cells (2016) (0)
- The Deep Dementia Phenotyping (DEMON) Network: A global platform for innovation using data science and artificial intelligence (2022) (0)
- Gene co-expression analysis identifies brain regions and cell types involved in migraine pathophysiology: a GWAS-based study using the Allen Human Brain Atlas (2016) (0)
- Serum High-Density Lipoprotein Cholesterol Levels Epistatic Effect of Cholesteryl Ester Transfer Protein and Hepatic Lipase on (2007) (0)
- Independent Multiple Factor Association Analysis for Multiblock Data in Imaging Genetics (2019) (0)
- Bone Mineral Density in Sjögren Syndrome Patients with and Without Distal Renal Tubular Acidosis (2016) (0)
- Author Correction: Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases (2019) (0)
- Cerebrovascular disease and dementia: exploring causal pathways (2022) (0)
- Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals (2018) (0)
- Publisher Correction: Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability (2019) (0)
- Linkage analysis for plasma amyloid beta levels in persons with hypertension implicates Aβ-40 levels to presenilin 2 (2012) (0)
- Unraveling Neuro-Proteogenomic Landscape and Therapeutic Implications for Human Behaviors and Psychiatric Disorders (2023) (0)
- Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes (2018) (0)
- Correction: Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images (2021) (0)
- Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation (2018) (0)
- Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug–metabolite atlas (2020) (0)
- Penetrance estimation of Alzheimer disease in SORL1 loss-of-function variant carriers using a family-based strategy and stratification by APOE genotypes (2022) (0)
- Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium (2014) (0)
- The genetic architecture of plasma adiponectin overlaps with the genetics of metabolic syndrome related traits Running Title: Shared heritability of adiponectin and the MetS (2010) (0)
- Correction: Association of low-frequency and rare coding variants with information processing speed (2022) (0)
- The &agr;2-macroglobulin gene in AD: A population-based study and meta-analysis (2000) (0)
- Author Correction: Heritability estimates for 361 blood metabolites across 40 genome-wide association studies (2020) (0)
- Rare variant analyses across multiethnic cohorts identify novel genes for refractive error (2021) (0)
- Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease (2020) (0)
- Common DNA variants predict tall stature in Europeans (2013) (0)
- Automated workflow-based exploitation of pathway databases provides new insights into genetic associations of metabolite profiles (2013) (0)
- Understanding the role of the chromosome 15q25.1 in COPD through epigenetics and transcriptomics (2018) (0)
- Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory (2014) (0)
- [Prion diseases in The Netherlands: twenty-nine years of surveillance]. (2022) (0)
- Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass (2017) (0)
- 376 META-ANALYSIS OF GENOME-WIDE ASSOCIATION DATA IMPLICATES THE 4P15.3 REGION TO INFLUENCE CHRONIC WIDESPREAD PAIN IN WOMEN (2010) (0)
- Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) (0)
- Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium (2015) (0)
- Rare missense variant (R251G) on APOE counterbalances the Alzheimer’s disease risk associated with APOE‐ε4 (2022) (0)
- Heritabilities, proportions of heritabilities explained by GWAS findings, and implications of cross-phenotype effects on PR interval (2015) (0)
- Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression (2020) (0)
- Sociodemographic, lifestyle and clinical characteristics of energy-related depression symptoms: A pooled analysis of 13,965 depressed cases in 8 Dutch cohorts. (2022) (0)
- Reply (2003) (0)
- Cross‐omics studies of the role of apolipoprotein E in Alzheimer’s disease and dementia: Searching common pathways in patients, populations and cellular models (2020) (0)
- Multidomain interventions: state-of-the-art and future directions for protocols to implement precision dementia risk reduction. A user manual for Brain Health Services—part 4 of 6 (2021) (0)
- Author Correction: Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps (2018) (0)
- Antidiabetic Medications and Eye Diseases (2021) (0)
- Publisher Correction: Identification of 371 genetic variants for age at first sex and birth linked to externalising behavior (2021) (0)
- Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction (2020) (0)
- An R package "VariABEL" for genome-wide searching of potentially interacting loci by testing genotypic variance heterogeneity (2012) (0)
- Does ethnicity influence dementia, stroke and mortality risk? Evidence from the UK Biobank (2021) (0)
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