Craig Mello
#4,281
Most Influential Person Now
American biologist
Craig Mello's AcademicInfluence.com Rankings
Craig Mellobiology Degrees
Biology
#190
World Rank
#350
Historical Rank
#110
USA Rank
Molecular Biology
#69
World Rank
#71
Historical Rank
#47
USA Rank
Genetics
#93
World Rank
#128
Historical Rank
#61
USA Rank
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Biology
Craig Mello's Degrees
- Bachelors Biochemistry Brown University
Why Is Craig Mello Influential?
(Suggest an Edit or Addition)According to Wikipedia, Craig Cameron Mello is an American biologist and professor of molecular medicine at the University of Massachusetts Medical School in Worcester, Massachusetts. He was awarded the 2006 Nobel Prize for Physiology or Medicine, along with Andrew Z. Fire, for the discovery of RNA interference. This research was conducted at the University of Massachusetts Medical School and published in 1998. Mello has been a Howard Hughes Medical Institute investigator since 2000.
Craig Mello's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans (1998) (14634)
- Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing (2001) (1941)
- The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans (1999) (1335)
- Revealing the world of RNA interference (2004) (1001)
- Chapter 19 DNA Transformation (1995) (919)
- Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals (2016) (891)
- RNAi in C. elegans: Soaking in the Genome Sequence (1998) (707)
- Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans Embryos (1997) (675)
- Analysis of the C. elegans Argonaute Family Reveals that Distinct Argonautes Act Sequentially during RNAi (2006) (631)
- The dsRNA Binding Protein RDE-4 Interacts with RDE-1, DCR-1, and a DExH-Box Helicase to Direct RNAi in C. elegans (2002) (553)
- piRNAs Initiate an Epigenetic Memory of Nonself RNA in the C. elegans Germline (2012) (542)
- PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans. (2008) (532)
- Sequence-Specific Inhibition of Small RNA Function (2004) (516)
- Genetic requirements for inheritance of RNAi in C. elegans. (2000) (504)
- Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline. (2009) (449)
- The Argonaute CSR-1 and Its 22G-RNA Cofactors Are Required for Holocentric Chromosome Segregation (2009) (418)
- Functional Proteomics Reveals the Biochemical Niche of C. elegans DCR-1 in Multiple Small-RNA-Mediated Pathways (2006) (392)
- The PIE-1 protein and germline specification in C. elegans embryos (1996) (350)
- C. elegans piRNAs Mediate the Genome-wide Surveillance of Germline Transcripts (2012) (327)
- Repression of gene expression in the embryonic germ lineage of C. elegans (1996) (323)
- Diverse pathways generate microRNA-like RNAs and Dicer-independent small interfering RNAs in fungi. (2010) (312)
- WRM-1 Activates the LIT-1 Protein Kinase to Transduce Anterior/Posterior Polarity Signals in C. elegans (1999) (310)
- Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants (2005) (284)
- par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3. (1996) (281)
- MEX-3 Is a KH Domain Protein That Regulates Blastomere Identity in Early C. elegans Embryos (1996) (274)
- The pie-1 and mex-1 genes and maternal control of blastomere identity in early C. elegans embryos (1992) (255)
- The maternal gene skn-1 encodes a protein that is distributed unequally in early C. elegans embryos (1993) (252)
- A Co-CRISPR Strategy for Efficient Genome Editing in Caenorhabditis elegans (2014) (242)
- pos-1 encodes a cytoplasmic zinc-finger protein essential for germline specification in C. elegans. (1999) (236)
- Robust Genome Editing with Short Single-Stranded and Long, Partially Single-Stranded DNA Donors in Caenorhabditis elegans (2018) (224)
- MEP-1 and a Homolog of the NURD Complex Component Mi-2 Act Together to Maintain Germline-Soma Distinctions in C. elegans (2002) (207)
- Argonautes ALG-3 and ALG-4 are required for spermatogenesis-specific 26G-RNAs and thermotolerant sperm in Caenorhabditis elegans (2010) (206)
- The C. elegans CSR-1 argonaute pathway counteracts epigenetic silencing to promote germline gene expression. (2013) (203)
- CDE-1 Affects Chromosome Segregation through Uridylation of CSR-1-Bound siRNAs (2009) (189)
- CapSeq and CIP-TAP Identify Pol II Start Sites and Reveal Capped Small RNAs as C. elegans piRNA Precursors (2012) (185)
- Sequential rounds of RNA-dependent RNA transcription drive endogenous small-RNA biogenesis in the ERGO-1/Argonaute pathway (2010) (184)
- SRC-1 and Wnt signaling act together to specify endoderm and to control cleavage orientation in early C. elegans embryos. (2002) (178)
- A CBP/p300 homolog specifies multiple differentiation pathways in Caenorhabditis elegans. (1998) (174)
- Inducible systemic RNA silencing in Caenorhabditis elegans. (2003) (159)
- Argonautes Promote Male Fertility and Provide a Paternal Memory of Germline Gene Expression in C. elegans (2013) (158)
- Identification of piRNA Binding Sites Reveals the Argonaute Regulatory Landscape of the C. elegans Germline (2018) (153)
- MicroRNA-regulated, Systemically Delivered rAAV9: A Step Closer to CNS-restricted Transgene Expression (2010) (146)
- The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans. (2002) (141)
- RNA interference-mediated antiviral defense in insects (2015) (129)
- RNA Interference in Caenorhabditis elegans (2003) (116)
- A Member of the Polymerase β Nucleotidyltransferase Superfamily Is Required for RNA Interference in C. elegans (2005) (109)
- Specific miRNA stabilization by Gld2-catalyzed monoadenylation. (2012) (104)
- The RNase PARN-1 Trims piRNA 3′ Ends to Promote Transcriptome Surveillance in C. elegans (2016) (101)
- The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegans (2006) (101)
- par-2, a gene required for blastomere asymmetry in Caenorhabditis elegans, encodes zinc-finger and ATP-binding motifs. (1994) (96)
- Functional conservation between members of an ancient duplicated transcription factor family, LSF/Grainyhead. (2003) (95)
- RNAi (Nematodes: Caenorhabditis elegans). (2002) (88)
- Wnt signaling drives WRM-1/beta-catenin asymmetries in early C. elegans embryos. (2005) (86)
- Genetic identification, sequence, and alternative splicing of the Caenorhabditis elegans alpha 2(IV) collagen gene (1993) (81)
- The minibrain kinase homolog, mbk-2, is required for spindle positioning and asymmetric cell division in early C. elegans embryos. (2004) (76)
- Suppression of pervasive noncoding transcription in embryonic stem cells by esBAF (2015) (76)
- An inductive interaction in 4-cell stage C. elegans embryos involves APX-1 expression in the signalling cell. (1996) (72)
- RDE-2 interacts with MUT-7 to mediate RNA interference in Caenorhabditis elegans (2005) (69)
- ZNFX-1 Functions within Perinuclear Nuage to Balance Epigenetic Signals. (2018) (68)
- A Ribonuclease Coordinates siRNA Amplification and mRNA Cleavage during RNAi (2015) (67)
- Influenza A virus preferentially snatches noncoding RNA caps (2015) (60)
- The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins. (2004) (59)
- The Antiviral RNA Interference Response Provides Resistance to Lethal Arbovirus Infection and Vertical Transmission in Caenorhabditis elegans (2017) (53)
- The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis (2006) (52)
- NMY-2 maintains cellular asymmetry and cell boundaries, and promotes a SRC-dependent asymmetric cell division. (2010) (51)
- A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes (2016) (51)
- Melting dsDNA Donor Molecules Greatly Improves Precision Genome Editing in Caenorhabditis elegans (2020) (45)
- Return to the RNAi world: rethinking gene expression and evolution. (2007) (42)
- The Coding Regions of Germline mRNAs Confer Sensitivity to Argonaute Regulation in C. elegans (2018) (38)
- A Sex Chromosome piRNA Promotes Robust Dosage Compensation and Sex Determination in C. elegans. (2018) (38)
- HAT activity is essential for CBP‐1‐dependent transcription and differentiation in Caenorhabditis elegans (2002) (33)
- Wnt and CDK-1 regulate cortical release of WRM-1/β-catenin to control cell division orientation in early Caenorhabditis elegans embryos (2013) (33)
- The Translin-TRAX complex/C3PO is a ribonuclease in tRNA processing (2012) (32)
- Tudor domain ERI-5 tethers an RNA-dependent RNA polymerase to DCR-1 to potentiate endo-RNAi (2011) (32)
- Tudor domain ERI-5 tethers an RNA-dependent RNA polymerase to DCR-1 to potentiate endo-RNAi (2013) (32)
- GCNA interacts with Spartan and Topoisomerase II to regulate genome stability (2019) (32)
- Return to the RNAi world: rethinking gene expression and evolution (2007) (31)
- The Vasa Homolog RDE-12 Engages Target mRNA and Multiple Argonaute Proteins to Promote RNAi in C. elegans (2014) (31)
- Micromanaging insulin secretion (2004) (23)
- Divide and differentiate (2014) (23)
- Cloning Argonaute-associated small RNAs from Caenorhabditis elegans. (2011) (23)
- 5′ Modifications Improve Potency and Efficacy of DNA Donors for Precision Genome Editing (2018) (22)
- Return to the RNAi World: Rethinking Gene Expression and Evolution (Nobel Lecture) (2007) (21)
- Chromatin regulation during C. elegans germline development. (2003) (19)
- Microinjection for precision genome editing in Caenorhabditis elegans (2021) (19)
- POS-1 Promotes Endo-mesoderm Development by Inhibiting the Cytoplasmic Polyadenylation of neg-1 mRNA. (2015) (18)
- A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection (2014) (15)
- The RNA phosphatase PIR-1 regulates endogenous small RNA pathways in C. elegans (2020) (15)
- Melting dsDNA Donor Molecules Greatly Improves Precision Genome Editing in Caenorhabditis elegans. (2020) (13)
- Germ granule dysfunction is a hallmark and mirror of Piwi mutant sterility (2021) (12)
- A Co-CRISPR Strategy for Efficient Genome Editing in C. elegans (2014) (12)
- 5′-Modifications improve potency and efficacy of DNA donors for precision genome editing (2021) (11)
- Wnt signaling drives WRM-1/ (cid:1) -catenin asymmetries in early C. elegans embryos (2005) (10)
- HDAC1 SUMOylation promotes Argonaute directed transcriptional silencing in C. elegans (2020) (8)
- A conversation with Craig C Mello on the discovery of RNAi (2007) (6)
- morphogenesis and cell migrations in C . elegans The GEX-2 and GEX-3 proteins are required for tissue (2002) (5)
- Cues from mRNA splicing prevent default Argonaute silencing in C. elegans. (2021) (4)
- PIE-1 SUMOylation promotes germline fates and piRNA-dependent silencing in C. elegans (2021) (4)
- HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans (2021) (4)
- Primal RNAs: The End of the Beginning? (2010) (4)
- Caenorhabditis elegans DNA that directs segregation in yeast cells. (1985) (3)
- A C. elegans model for the rare human channelopathy, Timothy syndrome type 1 (2018) (3)
- Robust genome editing with short single-stranded and long, partially single-stranded DNA donors in C. elegans (2018) (3)
- RNA-silencing induces target gene relocalization toward a specialized nuage domain (2021) (3)
- Melting dsDNA donor molecules potentiates precision genome editing in C. elegans (2020) (3)
- Inductive asymmetric cell division: The WRM leads the way (2014) (2)
- The RNase PARN-1 Trims piRNA 3 0 Ends to Promote Transcriptome Surveillance in C . elegans Graphical (1)
- Blood chimerism in twins (2018) (1)
- POS-1 and germ cell specification (1998) (1)
- The Time to Demand Funding (2009) (1)
- Author response: 5′-Modifications improve potency and efficacy of DNA donors for precision genome editing (2021) (1)
- A family of C. elegans VASA homologs control Argonaute pathway specificity and promote transgenerational silencing (2022) (1)
- Efficient gene transfer inC.elegans: extrachromosomal maintenance andintegration oftransforming sequences (1991) (0)
- The Nobel Prize in Physiology or Medicine for 2006 jointly to Andrew Fire and Craig Mello “ for their discovery of RNA interference – gene silencing by double-stranded RNA (2007) (0)
- Author response: A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection (2014) (0)
- elegans embryos-catenin asymmetries in early C . β Wnt signaling drives WRM-1 / Material Supplemental (2013) (0)
- Craig C. Mello (1960 (2017) (0)
- Evidence for a Temporal Window of Argonaute Surveillance Prior to mRNA Translation in the C. Elegans Germline (2018) (0)
- PIE-1 promotes SUMOylation and activation of HDAC1 during the C. elegans oogenesis (2020) (0)
- The nuclear Argonaute HRDE-1 directs target gene re-localization and shuttles to nuage to promote small RNA mediated inherited silencing (2022) (0)
- Production in vivo de petits arn d'interference qui regulent le silencage genique (2002) (0)
- Nonstop Decay in C. elegans: Examination of a Possible Role for Endogenous siRNAs (2016) (0)
- The human genome is peppered with genes for small microRNAs, whose functions are only beginning to come to light. One such microRNA is now implicated in the secretion of insulin from pancreatic beta cells. (2004) (0)
- par-2, agenerequired forblastomere asymmetry inCaenorhabditis elegans, encodes zinc-finger andATP-binding motifs (1994) (0)
- P.136 Occult B infection in the Brazilian northeastern region: a preliminary report (2006) (0)
- P.064 Spontaneous clearance of HBV markers among HBV carriers from an area of northeastern Brazil where genotype A prevails (2006) (0)
- Derived DNA Structured RNA RNA-RNA Hybrid RNA-viral RNA Hybrid Integration into Cellular Genome ? Transcription of Virus-Derived DNA Slicing (2015) (0)
- Author response: A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes (2016) (0)
- The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegans (2006) (0)
- Author response: A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes (2016) (0)
- Decision letter: High-fidelity, efficient, and reversible labeling of endogenous proteins using CRISPR-based designer exon insertion (2021) (0)
- ZNFX-1 Engages Argonaute Proteins to Promote the Stable Inheritance of Epigenetic States in C. Elegans (2018) (0)
- Author response: HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans (2021) (0)
- RNA Interference in Caenorhabditis Elegans (2003) (0)
- PNAS Plus Significance Statements (2012) (0)
- Author response: PIE-1 SUMOylation promotes germline fates and piRNA-dependent silencing in C. elegans (2021) (0)
- CHAIRMAN'S CORNER (2006) (0)
- Inductive asymmetric cell division (2013) (0)
- Touching base (2000) (0)
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What Schools Are Affiliated With Craig Mello?
Craig Mello is affiliated with the following schools:
