Curtis Dean Klaassen

Curtis Dean Klaassen's AcademicInfluence.com Rankings

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#361

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#511

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Toxicology

World Rank

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Pharmacology

#26

World Rank

#32

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Curtis Dean Klaassen's Degrees

PhD Pharmacology University of Kansas
Bachelors Pharmacy University of Kansas

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Curtis Dean Klaassen's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Casarett and Doull's Toxicology. The Basic Science of Poisons (1981) (2574)
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity (2001) (1270)
Metallothionein: an intracellular protein to protect against cadmium toxicity. (1999) (1126)
Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation (2010) (729)
Fatty Acid (2020) (728)
Metallothionein protection of cadmium toxicity. (2009) (595)
Structure, Function, Expression, Genomic Organization, and Single Nucleotide Polymorphisms of Human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) Efflux Transporters (2006) (377)
CASARETT AND DOULL'S TOXICOLOGY (2013) (364)
Nrf2 the rescue: effects of the antioxidative/electrophilic response on the liver. (2010) (335)
Mechanism of tissue‐specific farnesoid X receptor in suppressing the expression of genes in bile‐acid synthesis in mice (2012) (324)
The importance of 3‘‐phosphoadenosine 5‘‐phosphosulfate (PAPS) in the regulation of sulfation (1997) (319)
Oxidative and electrophilic stress induces multidrug resistance–associated protein transporters via the nuclear factor‐E2–related factor‐2 transcriptional pathway (2007) (312)
Toxicology of cadmium (1995) (303)
Beneficial role of Nrf2 in regulating NADPH generation and consumption. (2011) (280)
Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor. (2001) (275)
Cadmium-induced hepatic and renal injury in chronically exposed rats: likely role of hepatic cadmium-metallothionein in nephrotoxicity. (1985) (274)
Cadmium-induced apoptosis in mouse liver. (1998) (267)
Casarett and Doull's toxicology : the basic science of poisons :companion handbook (1999) (261)
INDUCTION OF THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN FAMILY OF TRANSPORTERS BY CHEMICAL ACTIVATORS OF RECEPTOR-MEDIATED PATHWAYS IN MOUSE LIVER (2005) (259)
Acute exposure to cadmium causes severe liver injury in rats. (1982) (256)
Introducing the "TCDD-inducible AhR-Nrf2 gene battery". (2009) (254)
Dose-response effects of various metal ions on rat liver metallothionein, glutathione, heme oxygenase, and cytochrome P-450. (1980) (245)
Coordinated Regulation of Hepatic Phase I and II Drug-Metabolizing Genes and Transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-Null Mice (2012) (228)
Increase in metallothionein produced by chemicals that induce oxidative stress. (1991) (226)
Cadmium toxicity and lipid peroxidation in isolated rat hepatocytes. (1980) (226)
Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC-MS/MS. (2008) (225)
Protective effect of metallothionein against the toxicity of cadmium and other metals(1). (2001) (221)
Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic. (2001) (220)
Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp/Abcg2) in rats and mice. (2004) (220)
NF-E2-Related Factor 2 Inhibits Lipid Accumulation and Oxidative Stress in Mice Fed a High-Fat Diet (2008) (218)
Relative effects of various chlorinated hydrocarbons on liver and kidney function in mice. (1966) (214)
Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats. (2002) (212)
Mechanisms of toxicity. (1969) (210)
TISSUE DISTRIBUTION AND HEPATIC AND RENAL ONTOGENY OF THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN (MRP) FAMILY IN MICE (2005) (199)
Comparison of the biochemical alterations elicited in livers from rats treated with carbon tetrachloride, chloroform, 1,1,2-trichloroethane and 1,1,1-trichloroethane. (1969) (199)
Tissue distribution and ontogeny of sulfotransferase enzymes in mice. (2006) (199)
Metallothioneins in brain--the role in physiology and pathology. (1997) (197)
Intestinal absorption of cadmium is associated with divalent metal transporter 1 in rats. (2002) (195)
Gender-specific and developmental influences on the expression of rat organic anion transporters. (2002) (189)
Reduction of thyroid hormone levels and alteration of thyroid function by four representative UDP-glucuronosyltransferase inducers in rats. (1994) (187)
Tissue mRNA expression of the rat UDP-glucuronosyltransferase gene family. (2003) (186)
UDP-glucuronosyltransferase inducers reduce thyroid hormone levels in rats by an extrathyroidal mechanism. (1992) (178)
Tissue- and Gender-Specific mRNA Expression of UDP-Glucuronosyltransferases (UGTs) in Mice (2007) (177)
Toxicity and distribution of cadmium administered to rats at sublethal doses. (1977) (173)
Tissue distribution and renal developmental changes in rat organic cation transporter mRNA levels. (2002) (172)
Casarett & Doull's Essentials of Toxicology (2015) (170)
Tissue distribution and chemical induction of multiple drug resistance genes in rats. (2002) (166)
Oxidative stress and the pathogenesis of cholestasis. (2010) (166)
Constitutive expression of various xenobiotic and endobiotic transporter mRNAs in the choroid plexus of rats. (2003) (165)
Tissue distribution and gender-divergent expression of 78 cytochrome P450 mRNAs in mice. (2011) (165)
TISSUE DISTRIBUTION AND ONTOGENY OF MOUSE ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPS) (2005) (164)
Regulation of hepatic transporters by xenobiotic receptors. (2005) (163)
Disposition of metals in rats: a comparative study of fecal, urinary, and biliary excretion and tissue distribution of eighteen metals. (1986) (162)
Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet. (2010) (162)
Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes. (2009) (161)
Zinc-induced tolerance to cadmium hepatotoxicity. (1984) (161)
Circadian Expression Profiles of Drug-Processing Genes and Transcription Factors in Mouse Liver (2009) (160)
Testicular toxicity of di-(2-ethylhexyl)phthalate in young Sprague-Dawley rats. (2002) (159)
Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats. (2004) (155)
Relative in vitro affinity of hepatic metallothionein for metals. (1984) (154)
Effect of bile duct ligation on bile acid composition in mouse serum and liver (2012) (154)
Production of Metallothionein and Heat-Shock Proteins in Response to Metals (1993) (152)
Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species. (2009) (151)
Transgenic mice that overexpress metallothionein-I are protected from cadmium lethality and hepatotoxicity. (1995) (151)
Transcriptional Regulation of Renal Cytoprotective Genes by Nrf2 and Its Potential Use as a Therapeutic Target to Mitigate Cisplatin-Induced Nephrotoxicity (2010) (151)
First-pass effect of morphine in rats. (1977) (151)
Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2. (2008) (148)
The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators. (2007) (144)
Detection of chemical-induced differential expression of rat hepatic cytochrome P450 mRNA transcripts using branched DNA signal amplification technology. (2000) (144)
Altered subcellular distribution of cadmium following cadmium pretreatment: possible mechanism of tolerance to cadmium-induced lethality. (1983) (143)
Isolation and characterization of metallothionein which is highly concentrated in newborn rat liver. (1979) (142)
Role of metallothionein in carcinogenesis. (1994) (142)
Induction of Mouse UDP-Glucuronosyltransferase mRNA Expression in Liver and Intestine by Activators of Aryl-Hydrocarbon Receptor, Constitutive Androstane Receptor, Pregnane X Receptor, Peroxisome Proliferator-Activated Receptor α, and Nuclear Factor Erythroid 2-Related Factor 2 (2009) (139)
Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR. (2008) (139)
Role of metallothionein in cadmium-induced hepatotoxicity and nephrotoxicity. (1997) (139)
Differential effects of microsomal enzyme inducers on in vitro thyroxine (T(4)) and triiodothyronine (T(3)) glucuronidation. (2000) (138)
Tissue distribution, ontogeny, and regulation of aldehyde dehydrogenase (Aldh) enzymes mRNA by prototypical microsomal enzyme inducers in mice. (2008) (137)
Differential expression of mouse hepatic transporter genes in response to acetaminophen and carbon tetrachloride. (2005) (137)
Rat and mouse differences in gender-predominant expression of organic anion transporter (Oat1-3; Slc22a6-8) mRNA levels. (2004) (137)
Review: Mechanisms of How the Intestinal Microbiota Alters the Effects of Drugs and Bile Acids (2015) (135)
Dietary iron regulates intestinal cadmium absorption through iron transporters in rats. (2004) (133)
Concentration of metallothionein in major organs of rats after administration of various metals. (1985) (133)
Effect of several metallothionein inducers on oxidative stress defense mechanisms in rats. (1995) (132)
Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co–therapy (2013) (132)
Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice[S] (2010) (131)
NRF2 Protection against Liver Injury Produced by Various Hepatotoxicants (2013) (130)
Biliary Excretion of Drugs in Man (1979) (130)
REGULATION OF MOUSE ORGANIC ANION-TRANSPORTING POLYPEPTIDES (OATPS) IN LIVER BY PROTOTYPICAL MICROSOMAL ENZYME INDUCERS THAT ACTIVATE DISTINCT TRANSCRIPTION FACTOR PATHWAYS (2005) (129)
Diurnal Variation of Hepatic Antioxidant Gene Expression in Mice (2012) (129)
Induction of rat organic anion transporting polypeptide 2 by pregnenolone-16alpha-carbonitrile is via interaction with pregnane X receptor. (2002) (128)
Induction of metallothionein as an adaptive mechanism affecting the magnitude and progression of toxicological injury. (1998) (128)
TISSUE DISTRIBUTION AND ONTOGENY OF ORGANIC CATION TRANSPORTERS IN MICE (2006) (128)
Protection of carbon tetrachloride-induced hepatotoxicity by zinc: role of metallothionein. (1979) (127)
Xenobiotic transporters: ascribing function from gene knockout and mutation studies. (2008) (127)
The relationship of metallothionein to the toxicity of cadmium after prolonged oral administration to rats. (1978) (127)
The presence of xenobiotic transporters in rat placenta. (2003) (127)
Dose-response of five bile acids on serum and liver bile Acid concentrations and hepatotoxicty in mice. (2011) (126)
Effect of Graded Nrf2 Activation on Phase-I and -II Drug Metabolizing Enzymes and Transporters in Mouse Liver (2012) (126)
Glucose and Insulin Induction of Bile Acid Synthesis (2011) (125)
Metallothionein (MT)-null mice are sensitive to cisplatin-induced hepatotoxicity. (1998) (124)
Alteration of thyroid homeostasis by UDP-glucuronosyltransferase inducers in rats: a dose-response study. (1995) (121)
Induction of Drug-Metabolizing Enzymes by Garlic and Allyl Sulfide Compounds via Activation of Constitutive Androstane Receptor and Nuclear Factor E2-Related Factor 2 (2007) (121)
Comparison of the effectiveness of several chelators after single administration on the toxicity, excretion, and distribution of cadmium. (1981) (120)
Nrf2 activation prevents cadmium-induced acute liver injury. (2012) (119)
TISSUE DISTRIBUTION OF CONCENTRATIVE AND EQUILIBRATIVE NUCLEOSIDE TRANSPORTERS IN MALE AND FEMALE RATS AND MICE (2004) (118)
Neurotoxic effects of cadmium in young rats. (1982) (118)
Carrier-mediated transport of ouabain in isolated hepatocytes. (1978) (118)
Final Report of the Safety Assessment of Kojic Acid as Used in Cosmetics (2010) (117)
Comparison of the effects of metals on cellular injury and lipid peroxidation in isolated rat hepatocytes. (1981) (115)
Hepatic phase I and phase II biotransformations in quail and trout: comparison to other species commonly used in toxicity testing. (1983) (113)
Biliary excretion of manganese in rats, rabbits, and dogs. (1974) (113)
Molecular targets of epigenetic regulation and effectors of environmental influences. (2010) (112)
Final Report of the Safety Assessment of Hyaluronic Acid, Potassium Hyaluronate, and Sodium Hyaluronate (2009) (112)
Susceptibility of MT-null mice to chronic CdCl2-induced nephrotoxicity indicates that renal injury is not mediated by the CdMT complex. (1998) (111)
Time course of cadmium-induced ultrastructural changes in rat liver. (1984) (111)
Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation. (2012) (110)
Tissue Distribution, Gender-Divergent Expression, Ontogeny, and Chemical Induction of Multidrug Resistance Transporter Genes (Mdr1a, Mdr1b, Mdr2) in Mice (2009) (110)
Studies on the mechanism of phenobarbital-enhanced sulfobromophthalein disappearance. (1968) (108)
Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid. (2008) (108)
Effects of microsomal enzyme inducers on thyroid-follicular cell proliferation, hyperplasia, and hypertrophy. (1999) (108)
Organic anion–transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2‐null mice (2011) (107)
Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia. (2012) (106)
ANIT-induced intrahepatic cholestasis alters hepatobiliary transporter expression via Nrf2-dependent and independent signaling. (2009) (106)
Effect of various antibiotics on modulation of intestinal microbiota and bile acid profile in mice. (2014) (106)
Changes in hepatic glutathione concentration modify cadmium-induced hepatotoxicity. (1984) (105)
Th2 Skewing by Activation of Nrf2 in CD4+ T Cells (2012) (105)
The effect of Chinese hepatoprotective medicines on experimental liver injury in mice. (1994) (104)
Metallothionein transgenic and knock-out mouse models in the study of cadmium toxicity. (1998) (104)
Comprar Casarett & Doull's Toxicology: The Basic Science of Poisons | Curtis Klaassen | 9780071470513 | Mcgraw-Hill Education (2008) (104)
Induction of metallothionein mRNA and protein in murine astrocyte cultures. (1996) (103)
Metallothionein-null mice are more sensitive than wild-type mice to liver injury induced by repeated exposure to cadmium. (2000) (102)
Inhibition of lipid peroxidation without prevention of cellular injury in isolated rat hepatocytes. (1981) (102)
Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1alpha. (2006) (102)
Maximum Biliary Excretion of Bilirubin and Sulfobromophthalein During Anesthesia-Induced Alteration of Rectal Temperature.∗ (1967) (102)
Increase in hepatic metallothionein in rats treated with alkylating agents. (1979) (102)
NUCLEAR RECEPTOR, PREGNANE X RECEPTOR, IS REQUIRED FOR INDUCTION OF UDP-GLUCURONOSYLTRANSFERASES IN MOUSE LIVER BY PREGNENOLONE-16α-CARBONITRILE (2003) (101)
CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes. (2009) (101)
Induction of Rat UDP-Glucuronosyltransferases in Liver and Duodenum by Microsomal Enzyme Inducers That Activate Various Transcriptional Pathways (2006) (101)
Chronic combined exposure to cadmium and arsenic exacerbates nephrotoxicity, particularly in metallothionein-I/II null mice. (2000) (101)
Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice. (2009) (101)
The effects of 10 triterpenoid compounds on experimental liver injury in mice. (1994) (100)
Biliary flow after microsomal enzyme induction. (1969) (100)
Metallothionein-I/II knockout mice are sensitive to acetaminophen-induced hepatotoxicity. (1999) (99)
Effects of Microsomal Enzyme Inducers on Thyroid Follicular Cell Proliferation and Thyroid Hormone Metabolism (2001) (98)
Tolerance to cadmium-induced hepatotoxicity following cadmium pretreatment. (1984) (98)
Comparison of methods for estimating hepatic metallothionein in rats. (1977) (96)
Cadmium uptake by isolated rat hepatocytes. (1980) (96)
Nuclear Factor Erythroid 2-Related Factor 2 Deletion Impairs Glucose Tolerance and Exacerbates Hyperglycemia in Type 1 Diabetic Mice (2010) (96)
The protective effect of metallothionein on the toxicity of various metals in rat primary hepatocyte culture. (1991) (95)
Three Patterns of Cytochrome P450 Gene Expression during Liver Maturation in Mice (2009) (95)
Induction studies on the functional heterogeneity of rat liver UDP-glucuronosyltransferases. (1982) (95)
Tissue distribution and thyroid hormone regulation of Pept1 and Pept2 mRNA in rodents (2006) (95)
Regulation of metal transporters by dietary iron, and the relationship between body iron levels and cadmium uptake (2007) (93)
Dosage-dependent disposition of cadmium administered orally to rats. (1986) (93)
Species variation in toxication and detoxication of acetaminophen in vivo: a comparative study of biliary and urinary excretion of acetaminophen metabolites. (1988) (93)
RNA-Seq Quantification of Hepatic Drug Processing Genes in Germ-Free Mice (2015) (92)
Diurnal Variations of Mouse Plasma and Hepatic Bile Acid Concentrations as well as Expression of Biosynthetic Enzymes and Transporters (2011) (92)
Regulation of rat multidrug resistance protein 2 by classes of prototypical microsomal enzyme inducers that activate distinct transcription pathways. (2002) (92)
Regulation of Hepatic Drug-Metabolizing Enzymes in Germ-Free Mice by Conventionalization and Probiotics (2016) (92)
Constitutive mRNA expression of various glutathione S-transferase isoforms in different tissues of mice. (2007) (91)
Constitutive expression of metallothionein genes in mouse brain. (1995) (91)
Effects of phenobarbital on the plasma disappearance and biliary excretion of drugs in rats. (1970) (90)
Metallothionein-I/II null mice are sensitive to chronic oral cadmium-induced nephrotoxicity. (2000) (89)
Tolerance to cadmium-induced toxicity depends on presynthesized metallothionein in liver. (1984) (88)
Regulation of Sulfotransferase Enzymes by Prototypical Microsomal Enzyme Inducers in Mice (2008) (88)
Cadmium absorption and its relationship to divalent metal transporter-1 in the pregnant rat. (2002) (88)
Effect of Diet on Expression of Genes Involved in Lipid Metabolism, Oxidative Stress, and Inflammation in Mouse Liver–Insights into Mechanisms of Hepatic Steatosis (2014) (86)
Effect of oleanolic acid on hepatic toxicant-activating and detoxifying systems in mice. (1995) (85)
Repeated administration of berberine inhibits cytochromes P450 in humans (2012) (85)
Final Report of the Safety Assessment of Methylisothiazolinone (2010) (84)
Distribution and retention of cadmium in metallothionein I and II null mice. (1996) (84)
Induction of metallothionein by arsenicals in mice. (1993) (82)
Induction of multidrug resistance protein 3 in rat liver is associated with altered vectorial excretion of acetaminophen metabolites. (2003) (82)
Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice. (2009) (82)
Bromobenzene-induced hepatotoxicity at the transcriptome level. (2004) (82)
Tissue expression, ontogeny, and inducibility of rat organic anion transporting polypeptide 4. (2002) (81)
Production of metallothionein and heat-shock proteins in response to metals. (1993) (81)
Biliary excretion of arsenic in rats, rabbits, and dogs. (1974) (81)
Relationship between liver and kidney levels of glutathione and metallothionein in rats. (1981) (81)
Support of science-based decisions concerning the evaluation of the toxicology of mixtures: a new beginning. (2002) (81)
Regulation of hepatic bile acid transporters Ntcp and Bsep expression. (2007) (81)
Protective effects of oleanolic acid on acetaminophen-induced hepatotoxicity in mice. (1993) (81)
Importance of Hepatic Induction of Constitutive Androstane Receptor and Other Transcription Factors That Regulate Xenobiotic Metabolism and Transport (2007) (81)
Effect of microsomal enzyme inducers on the biliary excretion of cardiac glycosides. (1974) (80)
Biliary excretion of metals. (1976) (80)
Tissue-specific expression of rat sulfotransferase messenger RNAs. (1998) (79)
Increase in rat liver UDP-glucuronosyltransferase mRNA by microsomal enzyme inducers that enhance thyroid hormone glucuronidation. (2002) (79)
Metallothionein-null mice are highly susceptible to the hematotoxic and immunotoxic effects of chronic CdCl2 exposure. (1999) (79)
Acute cadmium exposure induces stress-related gene expression in wild-type and metallothionein-I/II-null mice. (2002) (78)
Acute CdMT injection is not a good model to study chronic Cd nephropathy: comparison of chronic CdCl2 and CdMT exposure with acute CdMT injection in rats. (1998) (78)
National Cancer Institute workshop on the possible roles of metallothionein in carcinogenesis. (1993) (78)
Metallothionein-I and -II knock-out mice are sensitive to cadmium-induced liver mRNA expression of c-jun and p53. (1996) (78)
Genetic Activation of Nrf2 Protects against Fasting-Induced Oxidative Stress in Livers of Mice (2013) (78)
Regulation of transporter expression in mouse liver, kidney, and intestine during extrahepatic cholestasis. (2007) (77)
Studies on the increased biliary flow produced by phenobarbital in rats. (1971) (76)
Tissue distribution, ontogeny and induction of the transporters Multidrug and toxin extrusion (MATE) 1 and MATE2 mRNA expression levels in mice. (2008) (76)
Induction of hepatic glutathione S-transferases in male mice by prototypes of various classes of microsomal enzyme inducers. (2008) (76)
The effect of chelating agents on the excretion of endogenous metals. (1982) (76)
Induction of Hepatic Transporters Multidrug Resistance-Associated Proteins (Mrp) 3 and 4 by Clofibrate Is Regulated by Peroxisome Proliferator-Activated Receptor α (2006) (76)
Biliary excretion of colchicine. (1975) (75)
Regulation of mRNA Expression of Xenobiotic Transporters by the Pregnane X Receptor in Mouse Liver, Kidney, and Intestine (2006) (75)
Chemical modulation of metallothionein I and III mRNA in mouse brain (1995) (75)
Induction of metallothionein mRNA and protein in primary murine neuron cultures. (1996) (75)
Tissue Distribution, Ontogeny, and Hormonal Regulation of Xenobiotic Transporters in Mouse Kidneys (2009) (75)
Age difference in the susceptibility to cadmium-induced testicular damage in rats. (1980) (75)
Nrf2 protects against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative injury and steatohepatitis. (2011) (75)
Multidrug-resistance mdr1a/1b double knockout mice are more sensitive than wild type mice to acute arsenic toxicity, with higher arsenic accumulation in tissues. (2002) (74)
Characterization of metallothionein-I-transgenic mice. (1995) (74)
Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet. (2012) (73)
Safety Assessment of Propylene Glycol, Tripropylene Glycol, and PPGs as Used in Cosmetics (2012) (73)
Dynamic Patterns of Histone Methylation Are Associated with Ontogenic Expression of the Cyp3a Genes during Mouse Liver Maturation (2009) (72)
ChIPing the cistrome of PXR in mouse liver (2010) (72)
Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium (2015) (72)
Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor. (2010) (71)
Uptake of bile acids by isolated rat hepatocytes. (1982) (71)
Screening of Natural Compounds as Activators of the Keap1-Nrf2 Pathway (2013) (71)
Decreased effectiveness of chelation therapy with time after acute cadmium poisoning. (1982) (71)
Endocrine regulation of rat organic anion transporters. (2003) (70)
Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures. (2014) (70)
Effects of cysteine pro-drugs on acetaminophen-induced hepatotoxicity. (1986) (70)
Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors. (2008) (70)
Induction of T(4) UDP-GT activity, serum thyroid stimulating hormone, and thyroid follicular cell proliferation in mice treated with microsomal enzyme inducers. (2003) (70)
Glucuronidation and biliary excretion of acetaminophen in rats. (1984) (69)
Effect of metallothionein on hepatic disposition of metals. (1978) (69)
Importance of Large Intestine in Regulating Bile Acids and Glucagon-Like Peptide-1 in Germ-Free Mice (2015) (68)
Oxidative and conjugative metabolism of xenobiotics by livers of cattle, sheep, swine and rats. (1984) (68)
Rat liver microsomal UDP-glucuronosyltransferase activity toward thyroxine: characterization, induction, and form specificity. (1992) (68)
RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome. (2016) (67)
Metallothionein plays less of a protective role in cadmium-metallothionein-induced nephrotoxicity than in cadmium chloride-induced hepatotoxicity. (1996) (67)
Regulation of sulfotransferase mRNA expression in male and female rats of various ages. (1998) (67)
Sensitivity of thyroid gland growth to thyroid stimulating hormone (TSH) in rats treated with antithyroid drugs. (1999) (66)
Resistance to cadmium-induced hepatotoxicity in immature rats. (1984) (66)
Cadmium-binding proteins of rat testes. Characterization of a low-molecular-mass protein that lacks identity with metallothionein. (1984) (66)
Genetic background but not metallothionein phenotype dictates sensitivity to cadmium-induced testicular injury in mice. (2001) (66)
Differential effects of polychlorinated biphenyl congeners on serum thyroid hormone levels in rats. (2010) (66)
Lipoic acid impairs glycine conjugation of benzoic acid and renal excretion of benzoylglycine. (1996) (66)
In vitro and in vivo studies on the degradation of metallothionein. (1994) (66)
Effects of microsomal enzyme inducers on outer-ring deiodinase activity toward thyroid hormones in various rat tissues. (2000) (65)
Developmental Regulation of Drug-Processing Genes in Livers of Germ-Free Mice. (2015) (65)
Plasma disappearance and biliary excretion of indocyanine green in rats, rabbits, and dogs. (1969) (65)
RNA Sequencing Reveals Dynamic Changes of mRNA Abundance of Cytochromes P450 and Their Alternative Transcripts during Mouse Liver Development (2012) (65)
Constitutive Androstane Receptor-Mediated Changes in Bile Acid Composition Contributes to Hepatoprotection from Lithocholic Acid-Induced Liver Injury in Mice (2009) (64)
Individual bile acids have differential effects on bile acid signaling in mice. (2015) (64)
Nuclear factor-E2-related factor 2 expression in liver is critical for induction of NAD(P)H:quinone oxidoreductase 1 during cholestasis (2006) (64)
Hepatic Ischemia-Reperfusion Induces Renal Heme Oxygenase-1 via NF-E2-Related Factor 2 in Rats and Mice (2007) (63)
Effect of lipoic acid on biliary excretion of glutathione and metals. (1992) (63)
Prominent Expression of Xenobiotic Efflux Transporters in Mouse Extraembryonic Fetal Membranes Compared with Placenta (2008) (63)
CYP2D plays a major role in berberine metabolism in liver of mice and humans (2011) (62)
Differential expression of the metallothionein gene in liver and brain of mice and rats. (1993) (62)
Chemically-induced alteration of UDP-glucuronic acid concentration in rat liver. (1983) (62)
Studies on the pregnenolone-16 alpha-carbonitrile-inducible form of rat liver microsomal cytochrome P-450 and UDP-glucuronosyltransferase. (1987) (62)
Immaturity of the newborn rat's hepatic excretory function for ouabain. (1972) (62)
Cadmium decreases gap junctional intercellular communication in mouse liver. (2000) (62)
Interaction of metal ions with cadmium-induced cellular toxicity. (1981) (62)
Species variation in metabolism, storage, and excretion of sulfobromophthalein. (1967) (62)
Effect of microsomal enzyme inducers on the biliary excretion of triiodothyronine (T(3)) and its metabolites. (2002) (61)
Role of hepatic transporters in prevention of bile acid toxicity after partial hepatectomy in mice. (2009) (61)
Effect of microsomal enzyme inducers on the soluble enzymes of hepatic phase II biotransformation. (1982) (61)
Induction of multidrug resistance protein 3 (mrp3) in vivo is independent of constitutive androstane receptor. (2003) (61)
Kidney synthesizes less metallothionein than liver in response to cadmium chloride and cadmium-metallothionein. (1988) (60)
Induction profile of rat organic anion transporting polypeptide 2 (oatp2) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways. (2002) (60)
Rat multidrug resistance protein 4 (Mrp4, Abcc4): molecular cloning, organ distribution, postnatal renal expression, and chemical inducibility. (2004) (60)
Up-regulation of Mrp4 expression in kidney of Mrp2-deficient TR- rats. (2005) (60)
Coordinated induction of Nrf2 target genes protects against iron nitrilotriacetate (FeNTA)-induced nephrotoxicity. (2008) (60)
Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen. (2007) (60)
Absorption and distribution of cadmium in metallothionein-I transgenic mice. (1996) (60)
Mechanism of Gender-Divergent UDP-Glucuronosyltransferase mRNA Expression in Mouse Liver and Kidney (2009) (59)
Separation and quantitation of metallothioneins by high-performance liquid chromatography coupled with atomic absorption spectrophotometry. (1986) (59)
Effects of Aging on mRNA Profiles for Drug-Metabolizing Enzymes and Transporters in Livers of Male and Female Mice (2012) (59)
Accumulation and degradation of the protein moiety of cadmium-metallothionein (CdMT) in the mouse kidney. (1992) (58)
Nuclear receptor-mediated regulation of carboxylesterase expression and activity (2010) (58)
Induction of Metallothionein (1989) (58)
Hepatocytes from metallothionein-I and II knock-out mice are sensitive to cadmium- and tert-butylhydroperoxide-induced cytotoxicity. (1996) (58)
Metabolism and biliary excretion of ethacrynic acid. (1974) (58)
Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers. (2008) (57)
Biliary excretion of lead in rats, rabbits, and dogs. (1974) (57)
Role of sulfhydryls in the hepatotoxicity of organic and metallic compounds. (1985) (57)
Transient induction of hepatic metallothionein following oral ethanol administration. (1984) (57)
Acetaminophen decreases adenosine 3'-phosphate 5'-phosphosulfate and uridine diphosphoglucuronic acid in rat liver. (1985) (57)
Discrepancy between the nephrotoxic potencies of cadmium-metallothionein and cadmium chloride and the renal concentration of cadmium in the proximal convoluted tubules. (1995) (57)
Taxonomy and epidemiology of Mucor irregularis, agent of chronic cutaneous mucormycosis (2013) (56)
Regulation of hepatic sulfotransferases by steroidal chemicals in rats. (1996) (56)
Increased biliary excretion of thyroxine by microsomal enzyme inducers. (2001) (56)
Metallothionein-null mice are more susceptible than wild-type mice to chronic CdCl(2)-induced bone injury. (2000) (56)
Endotoxin pretreatment protects against the hepatotoxicity of acetaminophen and carbon tetrachloride: role of cytochrome P450 suppression. (2000) (55)
Identification of Modulators of the Nuclear Receptor Peroxisome Proliferator-Activated Receptor α (PPARα) in a Mouse Liver Gene Expression Compendium (2015) (55)
Ontogeny of Novel Cytochrome P450 Gene Isoforms during Postnatal Liver Maturation in Mice (2012) (55)
Postnatal ontogeny of metallothionein in various organs of the rat. (1984) (55)
Comparison of the toxicity and tissue distribution of cadmium in newborn and adult rats after repeated administration. (1980) (55)
Nuclear receptor, pregname X receptor, is required for induction of UDP-glucuronosyltranferases in mouse liver by pregnenolone-16 alpha-carbonitrile. (2003) (54)
Gender Differences in mRNA Expression of ATP-Binding Cassette Efflux and Bile Acid Transporters in Kidney, Liver, and Intestine of 5/6 Nephrectomized Rats (2008) (54)
Tissue distribution and retention of cadmium in rats during postnatal development: minimal role of hepatic metallothionein. (1980) (54)
Cadmium accumulation and metallothionein expression in brain of mice at different stages of development. (1996) (54)
Induction of metallothionein in rat primary hepatocyte cultures: evidence for direct and indirect induction. (1987) (54)
Increase in bile flow and biliary excretion of glutathione-derived sulfhydryls in rats by drug-metabolizing enzyme inducers is mediated by multidrug resistance protein 2. (2002) (53)
Gender-Divergent Profile of Bile Acid Homeostasis during Aging of Mice (2012) (52)
Acquired Cadmium Resistance in Metallothionein-I/II(–/–) Knockout Cells: Role of the T-Type Calcium Channel Cacnα1G in Cadmium Uptake (2006) (52)
Biliary excretion. (1987) (52)
High-performance liquid chromatographic analysis of glutathione and its thiol and disulfide degradation products. (1986) (52)
Biliary excretion of cadmium in the rat, rabbit, and dog. (1977) (51)
Differential effects of microsomal enzyme–inducing chemicals on the hepatic expression of rat organic anion transporters, OATP1 and OATP2 (2001) (51)
Induction of digitoxigenin monodigitoxoside UDP-glucuronosyltransferase activity by glucocorticoids and other inducers of cytochrome P-450p in primary monolayer cultures of adult rat hepatocytes and in human liver. (1986) (51)
Mechanisms of gender-specific regulation of mouse sulfotransferases (Sults) (2011) (50)
Metallothionein-like proteins in human placenta and fetal membranes. (1984) (50)
Species variation in hepatic metallothionein. (1994) (50)
The Nrf2 Activator Oltipraz Also Activates the Constitutive Androstane Receptor (2008) (50)
Alterations in hepatic mRNA expression of phase II enzymes and xenobiotic transporters after targeted disruption of hepatocyte nuclear factor 4 alpha. (2010) (50)
Comparative effectiveness of topical treatments for hydrofluoric acid burns. (1985) (50)
Induction of metallothioneiin by adrrenocortical steroids (1981) (50)
Induction of hepatic metallothionein by paraquat. (1992) (50)
Copper toxicity in isolated rat hepatocytes. (1981) (49)
Oleanolic acid protects against cadmium hepatotoxicity by inducing metallothionein. (1993) (49)
Effect of inducers and inhibitors of glucuronidation on the biliary excretion and choleretic action of valproic acid in the rat. (1982) (49)
Metallothionein-null and wild-type mice show similar cadmium absorption and tissue distribution following oral cadmium administration. (2001) (49)
RNA-Seq reveals different mRNA abundance of transporters and their alternative transcript isoforms during liver development. (2012) (49)
Final Amended Safety Assessment of Hydroquinone as Used in Cosmetics (2010) (49)
Transcription Factor-Mediated Regulation of Carboxylesterase Enzymes in Livers of Mice (2012) (49)
Availability of glycine and coenzyme A limits glycine conjugation in vivo. (1992) (49)
Gadolinium chloride pretreatment prevents cadmium chloride-induced liver damage in both wild-type and MT-null mice. (2002) (48)
Ontogeny and hormonal basis of male-dominant rat hepatic sulfotransferases. (1996) (48)
Dosage-dependent absorption of cadmium in the rat intestine measured in situ. (1989) (48)
Lack of protection against chemically induced injury to isolated hepatocytes by omission of calcium from the incubation medium. (1982) (48)
Hepatic disposition of phenoldibromphthalein disulfonate and sulfobromophthalein. (1968) (48)
Effect of inhibition of gamma-glutamyltranspeptidase on biliary and urinary excretion of glutathione-derived thiols and methylmercury. (1987) (48)
Cadmium-induced hepatic endothelial cell injury in inbred strains of mice. (1992) (48)
The effect of diethyldithiocarbamate on brain uptake of cadmium. (1982) (48)
Final Report of the Amended Safety Assessment of Sodium Laureth Sulfate and Related Salts of Sulfated Ethoxylated Alcohols (2010) (48)
Safety Assessment of Cyclomethicone, Cyclotetrasiloxane, Cyclopentasiloxane, Cyclohexasiloxane, and Cycloheptasiloxane (2011) (47)
Kupffer Cell-Mediated Downregulation of Hepatic Transporter Expression in Rat Hepatic Ischemia-Reperfusion (2006) (47)
Protective effect of oleanolic acid against chemical-induced acute necrotic liver injury in mice. (1995) (47)
Endocrine Regulation of Gender-Divergent Mouse Organic Anion-Transporting Polypeptide (Oatp) Expression (2006) (46)
Protein kinase C suppresses rat organic anion transporting polypeptide 1- and 2-mediated uptake. (2001) (46)
Plasma disappearance and biliary excretion of sulfobromophthalein and phenol-3,6-dibromphthalein disulfonate after microsomal enzyme induction. (1970) (46)
Resistance of some phase II biotransformation pathways to hepatotoxins. (1982) (45)
Dose-response of berberine on hepatic cytochromes P450 mRNA expression and activities in mice. (2011) (45)
Hepatic excretory function in the newborn rat. (1973) (45)
Synergistic interaction between genetics and disease on pravastatin disposition. (2014) (45)
Safety Assessment of Glycerin as Used in Cosmetics (2019) (45)
Induction of UDP-glucuronosyltransferase activities in Gunn, heterozygous, and Wistar rat livers by pregnenolone-16 alpha-carbonitrile. (1982) (44)
Degradation of Keap1 activates BH3-only proteins Bim and PUMA during hepatocyte lipoapoptosis (2014) (44)
Hormonal regulation of renal multidrug resistance-associated proteins 3 and 4 (Mrp3 and Mrp4) in mice. (2006) (44)
Effect of carbon tetrachloride on the metabolism, storage, and excretion of sulfobromophthalein. (1968) (44)
Effects of phenobarbital, pregnenolone-16alpha-carbonitrile, and propylthiouracil on thyroid follicular cell proliferation. (1999) (43)
Safety Assessment of Citric Acid, Inorganic Citrate Salts, and Alkyl Citrate Esters as Used in Cosmetics (2014) (43)
Interaction of metals and carbon tetrachloride on lipid peroxidation and hepatotoxicity. (1983) (43)
Final Report of the Cosmetic Ingredient Review Expert Panel Amended Safety Assessment of Calendula officinalis—Derived Cosmetic Ingredients (2010) (43)
Minimal role of metallothionein in decreased chelator efficacy for cadmium. (1983) (43)
Glucuronidation and sulfation in rabbit kidney. (1986) (43)
Bile flow and composition during bile acid depletion and administration. (1974) (43)
Characterization of organic anion-transporting polypeptide (Oatp) 1a1 and 1a4 null mice reveals altered transport function and urinary metabolomic profiles. (2011) (43)
Screening a mouse liver gene expression compendium identifies modulators of the aryl hydrocarbon receptor (AhR). (2015) (43)
Depletion of hepatic UDP-glucuronic acid by drugs that are glucuronidated. (1986) (43)
Dose-response effect of berberine on bile acid profile and gut microbiota in mice (2016) (43)
Final Report on the Safety Assessment of Cocos nucifera (Coconut) Oil and Related Ingredients (2011) (42)
RNA-Sequencing Quantification of Hepatic Ontogeny and Tissue Distribution of mRNAs of Phase II Enzymes in Mice (2013) (42)
Cadmium accumulation and detoxification by alveolar macrophages of cigarette smokers. (2003) (42)
Oleanolic acid reprograms the liver to protect against hepatotoxicants, but is hepatotoxic at high doses (2018) (41)
Increased bile acids in enterohepatic circulation by short-term calorie restriction in male mice. (2013) (41)
Biliary excretion of drugs: role of ligandin in newborn immaturity and in the action of microsomal enzyme inducers. (1975) (41)
trans-Stilbene Oxide Induces Expression of Genes Involved in Metabolism and Transport in Mouse Liver via CAR and Nrf2 Transcription Factors (2006) (41)
Genetic and epigenetic regulation and expression signatures of glutathione S-transferases in developing mouse liver. (2010) (40)
Atorvastatin induces bile acid-synthetic enzyme Cyp7a1 by suppressing FXR signaling in both liver and intestine in mice[S] (2014) (40)
Biliary excretion and enterohepatic circulation of paracetamol in the rat. (1983) (40)
Cloning of the full-length coding sequence of rat liver-specific organic anion transporter-1 (rlst-1) and a splice variant and partial characterization of the rat lst-1 gene. (2000) (40)
Uptake of unconjugated bilirubin by isolated rat hepatocytes. (1979) (40)
Ischemia-reperfusion of rat livers decreases liver and increases kidney multidrug resistance associated protein 2 (Mrp2). (2008) (40)
Zinc uptake by isolated rat hepatocytes. (1981) (40)
Postnatal expression and induction by pregnenolone-16alpha-carbonitrile of the organic anion-transporting polypeptide 2 in rat liver. (2002) (40)
Inhibitory effect of oleanolic acid on 12-O-tetradecanoylphorbol-13-acetate-induced gene expression in mouse skin. (1998) (40)
Zinc-induced arsenite tolerance in mice (1994) (39)
Induction of metallothionein-I and metallothionein-II in rats by cadmium and zinc. (1987) (39)
Linkage disequilibrium blocks, haplotype structure, and htSNPs of human CYP7A1 gene (2006) (39)
Zinc-induced arsenite tolerance in mice. (1994) (39)
Effects of microsomal enzyme inducers upon UDP-glucuronic acid concentration and UDP-glucuronosyltransferase activity in the rat intestine and liver. (1992) (39)
Full-length cDNA cloning and genomic organization of the mouse liver-specific organic anion transporter-1 (lst-1). (2000) (39)
Biliary excretion of mercury compounds. (1975) (39)
Tissue Distribution, Ontogeny, and Chemical Induction of Aldo-Keto Reductases in Mice (2013) (38)
Different mechanism of saturation of acetaminophen sulfate conjugation in mice and rats. (1996) (38)
Induction of metallothionein by diethyl maleate. (1992) (38)
Safety Assessment of Microbial Polysaccharide Gums as Used in Cosmetics (2016) (38)
Does bile acid secretion determine canalicular bile production in rats? (1971) (38)
Nephrotoxicity of intravenously injected cadmium-metallothionein: critical concentration and tolerance. (1988) (38)
Tumor Necrosis Factor-α-Null Mice Are Not Resistant to Cadmium Chloride-Induced Hepatotoxicity (2002) (38)
Induction of metallothionein by steroids in rat primary hepatocyte cultures. (1987) (37)
Role of liver-enriched transcription factors in the down-regulation of organic anion transporting polypeptide 4 (oatp4; oatplb2; slc21a10) by lipopolysaccharide. (2004) (37)
Safety Assessment of Benzyl Alcohol, Benzoic Acid and its Salts, and Benzyl Benzoate (2017) (37)
Gender differences in renal nuclear receptors and aryl hydrocarbon receptor in 5/6 nephrectomized rats. (2006) (37)
Cloning, expression, and ontogeny of mouse organic anion-transporting polypeptide-5, a kidney-specific organic anion transporter. (2001) (37)
Safety Assessment of Decyl Glucoside and Other Alkyl Glucosides as Used in Cosmetics (2013) (37)
Biliary excretion of cardiac glycosides. (1973) (36)
Distribution of cadmium after oral administration of cadmium-thionein to mice. (1984) (36)
Bile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice. (2012) (36)
Ontogeny and hormonal basis of female-dominant rat hepatic sulfotransferases. (1996) (36)
RNA-Seq Profiling of Intestinal Expression of Xenobiotic Processing Genes in Germ-Free Mice (2017) (36)
Oleanolic acid alters bile acid metabolism and produces cholestatic liver injury in mice. (2013) (36)
Mechanisms of regulation of rat hepatic metallothionein-I and metallothionein-II levels following administration of zinc. (1988) (36)
Safety Assessment of Triethanolamine and Triethanolamine-Containing Ingredients as Used in Cosmetics (2013) (36)
Hepatic ontogeny and tissue distribution of mRNAs of epigenetic modifiers in mice using RNA-sequencing (2012) (36)
Postnatal ontogeny and hormonal regulation of sulfotransferase SULT1B1 in male and female rats. (1999) (36)
Comparison of the effects of two-thirds hepatectomy and bile duct ligation on hepatic excretory function. (1974) (36)
Dependence of glycine conjugation on availability of glycine: role of the glycine cleavage system. (1993) (36)
Dysfunction of Organic Anion Transporting Polypeptide 1a1 Alters Intestinal Bacteria and Bile Acid Metabolism in Mice (2012) (35)
Retinoid X Receptor α Regulates the Expression of Glutathione S-transferase Genes and Modulates Acetaminophen-Glutathione Conjugation in Mouse Liver (2005) (35)
Safety Assessment of Vitis vinifera (Grape)-Derived Ingredients as Used in Cosmetics (2014) (35)
Epigenetic regulation of drug processing genes (2011) (35)
Expression and regulation of the sterol half-transporter genes ABCG5 and ABCG8 in rats. (2004) (35)
Metallothionein as a trap for reactive organic intermediates. (1981) (35)
Hepatic extraction of bile acids in rats. (1982) (35)
The effect of repeated administration of several chelators on the distribution and excretion of cadmium. (1982) (35)
Safety Assessment of Talc as Used in Cosmetics (2015) (35)
Expression of rat Multidrug Resistance Protein 2 (Mrp2) in male and female rats during normal and pregnenolone-16alpha-carbonitrile (PCN)-induced postnatal ontogeny. (2002) (34)
Biliary excretion of xenobiotics. (1975) (34)
RNA Sequencing Quantification of Xenobiotic-Processing Genes in Various Sections of the Intestine in Comparison to the Liver of Male Mice (2016) (34)
Final Report of the Safety Assessment of Allantoin and Its Related Complexes (2010) (34)
iNOS-null mice are not resistant to cadmium chloride-induced hepatotoxicity. (2002) (34)
Comparison of the toxicity of chemicals in newborn rats to bile duct-ligated and sham-operated rats and mice. (1973) (34)
Hormonal regulation of Cyp4a isoforms in mouse liver and kidney (2013) (34)
Redistribution of cadmium to blood of rats. (1981) (34)
Nrf2 protects against diquat-induced liver and lung injury (2012) (34)
Carrier-mediated transport of the organic cation procaine amide ethobromide by isolated rat liver parenchymal cells. (1978) (33)
Metallothionein in Biology and Medicine (1991) (33)
Sulfotransferase gene expression in primary cultures of rat hepatocytes. (1996) (33)
Determination of hepatic uridine 5'-diphosphoglucuronic acid concentration by conjugation with diethylstilbestrol. (1982) (33)
Dose-dependent intestinal glucuronidation and sulfation of acetaminophen in the rat in situ. (1990) (33)
Induction of hepatic metallothionein by alcohols: evidence for an indirect mechanism. (1987) (33)
Promotion of thyroid tumors in rats by pregnenolone-16alpha-carbonitrile (PCN) and polychlorinated biphenyl (PCB). (2004) (33)
Cadmium-binding proteins of rat testes. Apparent source of the protein of low molecular mass. (1984) (33)
Depletion of hepatic uridine diphosphoglucuronic acid decreases the biliary excretion of drugs. (1983) (33)
Effect of microsomal enzyme inducers on biliary and urinary excretion of acetaminophen metabolites in rats. Decreased hepatobiliary and increased hepatovascular transport of acetaminophen-glucuronide after microsomal enzyme induction. (1990) (32)
Induction of hepatic metallothionein in mouse liver following administration of chelating agents. (1985) (32)
Fibroblast growth factor (Fgf) 21 is a novel target gene of the aryl hydrocarbon receptor (AhR). (2014) (32)
Safety Assessment of 1,2-Glycols as Used in Cosmetics (2012) (32)
Analysis of strain difference in sensitivity to cadmium-induced hepatotoxicity in Fischer 344 and Sprague-Dawley rats. (2002) (32)
Activation of Nrf2 in the liver is associated with stress resistance mediated by suppression of the growth hormone-regulated STAT5b transcription factor (2018) (32)
Gender disparity of hepatic lipid homeostasis regulated by the circadian clock (2009) (32)
Inhibition of gap-junctional-intercellular communication in intact rat liver by nongenotoxic hepatocarcinogens. (2000) (32)
Implementation of a High-Throughput Screen for Identifying Small Molecules to Activate the Keap1-Nrf2-ARE Pathway (2012) (32)
Effect of pregnenolone-16 alpha-carbonitrile and dexamethasone on acetaminophen-induced hepatotoxicity in mice. (1992) (32)
Deciphering the Developmental Dynamics of the Mouse Liver Transcriptome (2015) (31)
Cadmium uptake by rat red blood cells. (1986) (31)
Short-term calorie restriction feminizes the mRNA profiles of drug metabolizing enzymes and transporters in livers of mice. (2014) (31)
Protective effect of pregnenolone-16 alpha-carbonitrile on acetaminophen-induced hepatotoxicity in hamsters. (1991) (31)
Pharmacokinetics of rose bengal in the rat, rabbit, dog and guinea pig. (1976) (31)
Alteration of tissue disposition of cadmium by chelating agents. (1984) (31)
Comparison of methods of metallothionein quantification: cadmium radioassay, mercury radioassay, and radioimmunoassay. (1985) (31)
Presystemic elimination of manganese in rats. (1982) (31)
RNA-Sequencing Quantification of Hepatic Ontogeny of Phase-I Enzymes in Mice (2013) (31)
Biliary excretion of silver in the rat, rabbit, and dog. (1979) (31)
Protection against phalloidin-induced liver injury by oleanolic acid involves Nrf2 activation and suppression of Oatp1b2. (2015) (31)
Repression of hepatobiliary transporters and differential regulation of classic and alternative bile acid pathways in mice during pregnancy. (2012) (31)
Species variations in biliary excretion of glutathione-related thiols and methylmercury. (1988) (31)
Uptake of morphine and nalorphine by isolated rat hepatocytes. (1978) (30)
Dose-response examination of UDP-glucuronosyltransferase inducers and their ability to increase both TGF-beta expression and thyroid follicular cell apoptosis. (1998) (30)
Mechanism of manganese-induced tolerance to cadmium lethality and hepatotoxicity. (1985) (30)
A radiometric method for the measurement of adenosine 3'-phosphate 5'-phosphosulfate in rat and mouse liver. (1985) (30)
Stimulation of the development of the hepatic excretory mechanism for ouabain in newborn rats with microsomal enzyme inducers. (1974) (30)
Determination of sulfobromophthalein storage and exertory rate in small animals. (1967) (30)
Metallothionein-I-transgenic mice are not protected from acute cadmium-metallothionein-induced nephrotoxicity. (1996) (29)
Homeostasis of sulfate and 3'-phosphoadenosine 5'-phosphosulfate in rats after acetaminophen administration. (1992) (29)
Age-Specific Regulation of Drug-Processing Genes in Mouse Liver by Ligands of Xenobiotic-Sensing Transcription Factors (2016) (29)
Overexpression of Nrf2 Protects against Microcystin-Induced Hepatotoxicity in Mice (2014) (29)
Distribution of cadmium chloride and cadmium-metallothionein to liver parenchymal, Kupffer, and endothelial cells: their relative ability to express metallothionein. (1992) (28)
Safety Assessment of α-Amino Acids as Used in Cosmetics (2013) (28)
Comparison of adenosine 3'-phosphate 5'-phosphosulfate concentrations in tissues from different laboratory animals. (1987) (28)
Comparison of biliary excretory function and bile composition in male, female, and lactating female rats. (1978) (28)
Binding of glutathione-depleting agents to metallothionein. (1980) (28)
Toxicokinetic and genomic analysis of chronic arsenic exposure in multidrug-resistance mdr1a/1b(−/−) double knockout mice (2004) (28)
Uptake of ouabain by isolated hepatocytes from livers of developing rats. (1979) (28)
Effects of Acute Administration of Taurocholic and Taurochenodeoxycholic Acid on Biliary Lipid Excretion in the Rat 1 (1976) (27)
Metallothionein protects against the nephrotoxicity produced by chronic CdMT exposure. (1999) (27)
Nephrotoxicity of CdCl2 and Cd-metallothionein in cultured rat kidney proximal tubules and LLC-PK1 cells. (1994) (27)
Final Report of the Amended Safety Assessment of Myristic Acid and Its Salts and Esters as Used in Cosmetics (2010) (27)
Effect of glutathione depletion on sulfate activation and sulfate ester formation in rats. (1988) (27)
DISINFECTION BY-PRODUCTS IN DRINKING WATER : CRITICAL ISSUES IN HEALTH EFFECTS RESEARCH (1997) (27)
Ethanol decreases cadmium hepatotoxicity in rats: possible role of hepatic metallothionein induction. (1990) (27)
Down-regulation of mouse organic anion-transporting polypeptide 4 (Oatp4; Oatp1b2; Slc21a10) mRNA by lipopolysaccharide through the toll-like receptor 4 (TLR4). (2004) (26)
Species variation in the biliary excretion of ouabain. (1972) (26)
Protection by zinc-metallothionein (ZnMT) against cadmium-metallothionein-induced nephrotoxicity. (1995) (26)
Biliary excretion of acetaminophen-glutathione as an index of toxic activation of acetaminophen: effect of chemicals that alter acetaminophen hepatotoxicity. (1989) (26)
Final Report of the Cosmetic Ingredient Review Expert Panel on the Safety Assessment of Cocamidopropyl betaine (CAPB) (2012) (26)
Safety Assessment of Plant-Derived Fatty Acid Oils (2017) (26)
Ontogeny and induction of hepatic isometallothioneins in immature rats. (1988) (26)
Choleretic effect of valproic acid in the rat (1981) (26)
Absorption, distribution, and excretion of zinc pyridinethione in rabbits. (1976) (26)
Hepatobiliary disposition of thyroid hormone in Mrp2-deficient TR- rats: reduced biliary excretion of thyroxine glucuronide does not prevent xenobiotic-induced hypothyroidism. (2009) (26)
On the disulfiram‐like activity of moxalactam (1982) (26)
Effects of butylated hydroxyanisole on acetaminophen hepatotoxicity and glucuronidation in vivo. (1986) (26)
Utilization of methionine as a sulfhydryl source for metallothionein synthesis in rat primary hepatocyte cultures. (1987) (26)
Safety Assessment of Alumina and Aluminum Hydroxide as Used in Cosmetics (2016) (26)
In vitro degradation of apo-, zinc-, and cadmium-metallothionein by cathepsins B, C, and D. (1992) (26)
Degradation and metal composition of hepatic isometallothioneins in rats. (1992) (25)
Hepatotoxicity of carbon tetrachloride in developing rats. (1979) (25)
Sulfation of acetaminophen and acetaminophen-induced alterations in sulfate and 3'-phosphoadenosine 5'-phosphosulfate homeostasis in rats with deficient dietary intake of sulfur. (1994) (25)
Hepatic extraction of nonmetabolizable xenobiotics in rats. (1979) (25)
Effects of microsomal enzyme inducers on carrier-mediated transport systems in isolated rat hepatocytes. (1979) (25)
Tissue distribution and induction of the rat multidrug resistance-associated proteins 5 and 6. (2006) (25)
From Classical Toxicology to Tox21: Some Critical Conceptual and Technological Advances in the Molecular Understanding of the Toxic Response Beginning From the Last Quarter of the 20th Century (2018) (25)
Relative effects of various chlorinated hydrocarbons on liver and kidney function in dogs. (1967) (25)
Uptake of sulfobromophthalein-glutathione conjugate by isolated hepatocytes. (1980) (24)
Effect of thyroid hormones on liver microsomal enzyme induction in rats exposed to 2,3,7,8,-tetra-chlorodibenzo-p-dioxin (1985) (24)
Amended Safety Assessment of Parabens as Used in Cosmetics (2020) (24)
Comparison of the effects of sodium sulfate and N-acetylcysteine on the hepatotoxicity of acetaminophen in mice. (1986) (23)
Transgenic mice overexpressing metallothionein are not resistant to adriamycin cardiotoxicity. (1996) (23)
Application of multivariate statistical procedures to identify transcription factors that correlate with MRP2, 3, and 4 mRNA in adult human livers (2009) (23)
Safety Assessment of Boron Nitride as Used in Cosmetics (2015) (23)
Simple method for analysis of diquat in biological fluids and tissues by high-performance liquid chromatography. (1995) (23)
Cyproterone acetate induces a cellular tolerance to cadmium in rat liver epithelial cells involving reduced cadmium accumulation. (2001) (23)
Loss of organic anion transporting polypeptide 1a1 increases deoxycholic acid absorption in mice by increasing intestinal permeability. (2011) (23)
The effect of inhibitors of mitochondrial energy production on hepatic glutathione, UDP-glucuronic acid, and adenosine 3'-phosphate-5'-phosphosulfate concentrations. (1986) (23)
Role of ligandin as a binding protein and as an enzyme in the biliary excretion of sulfobromophthalein. (1982) (23)
Xenobiotic Transporters: Another Protective Mechanism for Chemicals (2002) (23)
Final Report of the Cosmetic Ingredient Review Expert Panel Safety Assessment of Polymethyl Methacrylate (PMMA), Methyl Methacrylate Crosspolymer, and Methyl Methacrylate/Glycol Dimethacrylate Crosspolymer (2011) (22)
Hepatic isometallothioneins in mice: induction in adults and postnatal ontogeny. (1990) (22)
Genetic Polymorphisms in the TATA Box and Upstream Phenobarbital-Responsive Enhancer Module of the UGT1A1 Promoter Have Combined Effects on UDP-Glucuronosyltransferase 1A1 Transcription Mediated by Constitutive Androstane Receptor, Pregnane X Receptor, or Glucocorticoid Receptor in Human Liver (2009) (22)
Depletion of hepatic 3'-phosphoadenosine 5'-phosphosulfate (PAPS) and sulfate in rats by xenobiotics that are sulfated. (1995) (22)
Final Report of the Cosmetic Ingredient Review Expert Panel on the Safety Assessment of Dicarboxylic Acids, Salts, and Esters (2012) (22)
Hormonal and Chemical Regulation of Paraoxonases in Mice (2012) (22)
From the Cover: Identification of Natural Products as Inhibitors of Human Organic Anion Transporters (OAT1 and OAT3) and Their Protective Effect on Mercury-Induced Toxicity (2018) (21)
Effects of fibrates on the glycine conjugation of benzoic acid in rats. (1998) (21)
Safety Assessment of Amino Acid Alkyl Amides as Used in Cosmetics (2017) (21)
Protective effects of zinc on cultured rat primary hepatocytes to metals with low affinity for metallothionein. (1992) (21)
Disruption of thyroid hormone homeostasis in Ugt1a-deficient Gunn rats by microsomal enzyme inducers is not due to enhanced thyroxine glucuronidation. (2010) (21)
Nrf2 protects against furosemide-induced hepatotoxicity. (2014) (21)
Role of UDP-glucuronosyltransferase (UGT) 2B2 in metabolism of triiodothyronine: effect of microsomal enzyme inducers in Sprague Dawley and UGT2B2-deficient Fischer 344 rats. (2010) (21)
Ontogenic expression of hepatic Ahr mRNA is associated with histone H3K4 di-methylation during mouse liver development. (2009) (21)
Nrf2 activation enhances biliary excretion of sulfobromophthalein by inducing glutathione-S-transferase activity. (2009) (21)
Role of hepatic lysosomes in the degradation of metallothionein. (1992) (20)
Rat primary hepatocyte cultures are a good model for examining metallothionein-induced tolerance to cadmium toxicity (2007) (20)
Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury. (2012) (20)
Alteration of Bile Acid and Cholesterol Biosynthesis and Transport by Perfluorononanoic Acid (PFNA) in Mice (2018) (20)
Safety Assessment of Alkyl Esters as Used in Cosmetics (2015) (20)
Hepatic effects of a methionine-choline-deficient diet in hepatocyte RXRalpha-null mice. (2009) (20)
Effect of Alteration in Body Temperature on the Biliary Excretion of Copper 1 (1973) (20)
Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO) (2017) (20)
Safety Assessment of Rosmarinus officinalis (Rosemary)-Derived Ingredients as Used in Cosmetics (2018) (20)
Amended Safety Assessment of Formaldehyde and Methylene Glycol as Used in Cosmetics (2013) (20)
Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics (2019) (19)
Genotyping and haplotyping of CYP2C19 functional alleles on thin-film biosensor chips (2007) (19)
Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics (2018) (19)
Safety Assessment of Trimoniums as Used in Cosmetics (2012) (19)
Effects of phospholipase A2 inhibitors on diethyl maleate-induced lipid peroxidation and cellular injury in isolated rat hepatocytes. (1982) (19)
Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice. (2009) (19)
H1-antihistamines exacerbate high-fat diet-induced hepatic steatosis in wild-type but not in apolipoprotein E knockout mice. (2014) (19)
UDP-glucuronosyltransferase activity toward digitoxigenin-monodigitoxoside. Differences in activation and induction properties in rat and mouse liver. (1988) (19)
Induction of metallothionein in primary rat hepatocyte cultures. (1991) (19)
Comparison of the choleretic properties of bile acids. (1973) (19)
Induction of metallothionein by cadmium-metallothionein in rat liver: a proposed mechanism. (1992) (19)
Age- and sex-dependent induction of liver microsomal benzo[a]pyrene hydroxylase activity in rats treated with pregnenolone-16α-carbonitrile (PCN) (1985) (19)
Final Report of the Cosmetic Ingredient Review Expert Panel on the Safety Assessment of Pelargonic Acid (Nonanoic Acid) and Nonanoate Esters (2011) (19)
Susceptibility of Male and Female Mice to the Nephrotoxic and Hepatotoxic Properties of Chlorinated Hydrocarbons.∗ (1967) (19)
Uptake of galactose, ouabain and taurocholate into centrilobular and periportal enriched hepatocyte subpopulations. (1981) (19)
Examination of potential mechanism(s) of metallothionein induction by diethyl maleate. (1992) (19)
Suppression of liver cytochrome P450 by α-hederin : relevance to hepatoprotection (1995) (19)
Decreased glucuronidation of bilirubin by diethyl ether anesthesia. (1984) (19)
Ethanol Metabolism in Rats after Microsomal Metabolizing Enzyme Induction 1 (1969) (18)
Safety Assessment of Alkyl Benzoates as Used in Cosmetics (2012) (18)
Isolated rat hepatocytes as a model system for screening chelators for use in cadmium intoxication. (1983) (18)
Ontogeny of Hepatic Energy Metabolism Genes in Mice as Revealed by RNA-Sequencing (2014) (18)
Polychlorinated Biphenyl Congeners that Increase the Glucuronidation and Biliary Excretion of Thyroxine Are Distinct from the Congeners that Enhance the Serum Disappearance of Thyroxine (2012) (18)
Organic anion-transporting polypeptide 1a4 (Oatp1a4) is important for secondary bile acid metabolism. (2013) (18)
Bromobenzene-glutathione excretion into bile reflects toxic activation of bromobenzene in rats. (1992) (18)
Induction of hepatic metallothioneins determined at isoprotein and messenger RNA levels in glucocorticoid-treated rats. (1988) (18)
Gender-specific reduction of hepatic Mrp2 expression by high-fat diet protects female mice from ANIT toxicity. (2012) (17)
Final Report of the Safety Assessment of Cosmetic Ingredients Derived From Zea Mays (Corn) (2011) (17)
Final report on the safety assessment of Basic Violet 1, Basic Violet 3, and Basic Violet 4. (2009) (17)
Regulation of the isoforms of metallothionein (1989) (17)
Studies on the mechanism of spironolactone protection against indomethacin toxicity. (1976) (17)
Editor’s Highlight: Clofibrate Decreases Bile Acids in Livers of Male Mice by Increasing Biliary Bile Acid Excretion in a PPAR&agr;-Dependent Manner (2017) (17)
Extrahepatic Distribution of Sulfobromophthalein (1975) (17)
Cadmium toxicity in the newborn rat. (1982) (17)
Energy Restriction Does Not Compensate for the Reduced Expression of Hepatic Drug-Processing Genes in Mice with Aging (2010) (17)
Regulation of hepatic microRNA expression by hepatocyte nuclear factor 4 alpha (2017) (17)
INDUCTION OF GENES FOR METABOLISM AND TRANSPORT BY TRANS-STILBENE OXIDE IN LIVERS OF SPRAGUE-DAWLEY AND WISTAR-KYOTO RATS (2006) (17)
The essential role of the transporter ABCG2 in the pathophysiology of erythropoietic protoporphyria (2019) (17)
NF-E 2-Related Factor 2 Inhibits Lipid Accumulation and Oxidative Stress in Mice Fed a High-Fat Diet (2008) (17)
Activation of Constitutive Androstane Receptor (CAR) in Mice Results in Maintained Biliary Excretion of Bile Acids Despite a Marked Decrease of Bile Acids in Liver. (2016) (17)
Effect of galactosamine-induced hepatic UDP-glucuronic acid depletion on acetaminophen elimination in rats. Dispositional differences between hepatically and extrahepatically formed glucuronides of acetaminophen and other chemicals. (1988) (16)
Induction of hepatic metallothionein following administration of urethane. (1987) (16)
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin, kepone, and polybrominated biphenyls on transport systems in isolated rat hepatocytes. (1979) (16)
Effect of valproic acid on glycine conjugation of benzoic acid. (1993) (16)
Final Report of the Cosmetic Ingredient Review Expert Panel on the Safety Assessment of Methyl Acetate (2012) (15)
Final Amended Report of the Safety Assessment of Toluene-2,5-Diamine, Toluene-2,5-Diamine Sulfate, and Toluene-3,4-Diamine as Used in Cosmetics (2010) (15)
Expression of cytochrome P450 isozyme transcripts and activities in human livers (2020) (15)
Pharmacokinetics in metal toxicity. (1981) (15)
Comparisons of the toxicity of CdCl2 and Cd-metallothionein in isolated rat hepatocytes. (1989) (15)
Acute Immunotoxic Effects of Perfluorononanoic Acid (PFNA) in C57BL/6 Mice. (2013) (15)
Age-dependent biliary excretion of glutathione-related thiols in rats: role of gamma-glutamyltransferase. (1987) (15)
Role of CYP3A in isoniazid metabolism in vivo. (2014) (15)
Final Amended Report on the Safety Assessment of Ammonium Thioglycolate, Butyl Thioglycolate, Calcium Thioglycolate, Ethanolamine Thioglycolate, Ethyl Thioglycolate, Glyceryl Thioglycolate, Isooctyl Thioglycolate, Isopropyl Thioglycolate, Magnesium Thioglycolate, Methyl Thioglycolate, Potassium Thio (2009) (15)
Safety Assessment of Hydrolyzed Wheat Protein and Hydrolyzed Wheat Gluten as Used in Cosmetics (2018) (15)
Comparison of Biliary excretion of organic anions in mice and rats. (1982) (15)
Effect of sulfhydryl-deficient diets on hepatic metallothionein, glutathione, and adenosine 3'-phosphate 5'-phosphosulfate (PAPS) levels in rats. (1990) (15)
Persistent alterations in immune cell populations and function from a single dose of perfluorononanoic acid (PFNA) in C57Bl/6 mice. (2017) (15)
Safety assessment of alkyl PEG ethers as used in cosmetics. (2012) (15)
Final Report on the Safety Assessment of Sodium Cetearyl Sulfate and Related Alkyl Sulfates as Used in Cosmetics (2010) (14)
Safety Assessment of Citrus-Derived Peel Oils as Used in Cosmetics (2019) (14)
Safety Assessment of Galactomannans as Used in Cosmetics (2015) (14)
Final Amended Report on Safety Assessment on Aminomethyl Propanol and Aminomethyl Propanediol (2009) (14)
Final Report of the Amended Safety Assessment of PVM/MA Copolymer and Its Related Salts and Esters as Used in Cosmetics (2011) (14)
The effect of altered hepatic function on the toxicity, plasma disappearance and biliary excretion of diethylstilbestrol. (1973) (14)
Methanol Potentiation of Carbon Tetrachloride-lnduced Hepatotoxicity (1979) (14)
Development of UDP-glucuronosyltransferase activity toward digitoxigenin-monodigitoxoside in neonatal rats. (1985) (14)
Genomic organization and tissue-specific expression of splice variants of mouse organic anion transporting polypeptide 2. (2001) (14)
Thyroid hormone modulation of rat sulphotransferase mRNA expression (2000) (14)
Safety Assessment of Alkyl Glyceryl Ethers as Used in Cosmetics (2013) (14)
Tissue Distribution and Gender-Divergent Expression of 78 Cytochrome P 450 mRNAs in Mice (2011) (14)
Independence of Bile Acid and Ouabain Hepatic Uptake: Studies in the Newborn Rat 1 (1978) (14)
Biochemical assay of serum bile acids: methods and applications. (1997) (14)
Species difference in the choleretic response to bile salts (1972) (14)
Safety Assessment of PEGylated Oils as Used in Cosmetics (2014) (14)
Effect of spironolactone on the distribution of mercury. (1975) (14)
Increased UDP-glucuronosyltransferase activity and UDP-glucuronic acid concentration in the small intestine of butylated hydroxyanisole-treated mice. (1985) (14)
Tumor necrosis factor-alpha-null mice are not resistant to cadmium chloride-induced hepatotoxicity. (2002) (14)
[22] Separation and quantification of isometallothioneins by high-performance liquid chromatography — atomic absorption spectrometry (1991) (14)
Strain differences in the toxicity of cadmium to trigeminal ganglia in mice. (2001) (14)
Safety Assessment of Chlorphenesin as Used in Cosmetics (2014) (13)
Metallothionein-I transgenic mice are not protected from γ-radiation (1999) (13)
Safety Assessment of Alkyl PEG/PPG Ethers as Used in Cosmetics (2012) (13)
Aryl hydrocarbon receptor (AhR) mediated short‐term effects of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) on bile acid homeostasis in mice (2018) (13)
Expression of human CAR splicing variants in BAC-transgenic mice. (2013) (13)
Safety Assessment of Silk Protein Ingredients as Used in Cosmetics (2020) (13)
An isocratic reverse-phase high-performance liquid chromatographic assay for adenine nucleotides in rat liver. (1985) (13)
The effect of ethylenediaminetetraacetic acid (EDTA) and EDTA plus salicylate on acute cadmium toxicity and distribution. (1980) (13)
Effects of butylated hydroxyanisole on hepatic glucuronidation capacity in mice. (1985) (13)
Biliary excretion of acetaminophen in ureter-ligated rats. (1984) (12)
Effects of molybdate and pentachlorophenol on the sulfation of acetaminophen. (2000) (12)
Effect of reduced hepatic energy state on acetaminophen conjugation in rats. (1986) (12)
Disinfection by-products in drinking water: critical issues in health effects research. (1997) (12)
Induction of metallothionein by α-Hederin (1993) (12)
Protective effects of chromium on the toxicity of cadmium in vivo. (1983) (12)
In vivo modification of 3'-phosphoadenosine 5'-phosphosulfate and sulfate by infusion of sodium sulfate, cysteine, and methionine. (1995) (12)
Intestinal and Hepatobiliary Disposition of Drugs (1988) (12)
Safety Assessment of Cucumis sativus (Cucumber)-Derived Ingredients as Used in Cosmetics (2014) (12)
Hepatic carboxylesterases are differentially regulated in PPARα-null mice treated with perfluorooctanoic acid. (2019) (12)
The UDP-glucuronyltransferase inducers, phenobarbital and pregnenolone-16alpha-carbonitrile, enhance thyroid-follicular cell apoptosis: association with TGF-beta1 expression. (1999) (12)
Learning to program the liver. (2014) (12)
Inhibition of gap-junctional-intercellular communication in thyroid-follicular cells by propylthiouracil and low iodine diet. (2000) (12)
Safety Assessment of Alkyl Betaines as Used in Cosmetics (2018) (12)
Does hepatic ATP depletion impair glycine conjugation in vivo? (1996) (12)
Safety Assessment of Tripeptide-1, Hexapeptide-12, Their Metal Salts and Fatty Acyl Derivatives, and Palmitoyl Tetrapeptide-7 as Used in Cosmetics (2018) (12)
Circadian variation of hepatic UDP-glucuronic acid and the glucuronidation of xenobiotics in mice. (1991) (11)
Effect of repeated oral administration on taurocholate on hepatic excretory function in the rat. (1981) (11)
Cadmium-induced elevation of hepatic isometallothionein concentrations in inbred strains of mice. (1991) (11)
Amended Final Safety Assessment Benzyl Alcohol, and Benzoic Acid and its Salts and Benzyl Ester (2011) (11)
Safety Assessment of PEGylated Alkyl Glycerides as Used in Cosmetics (2020) (11)
Homeostasis of sulfate and 3'-phosphoadenosine 5'-phosphosulfate in rats with deficient dietary intake of sulfur. (1992) (11)
Effect of various diets on the expression of phase-I drug-metabolizing enzymes in livers of mice (2015) (11)
Transplacental arsenic exposure produced 5-methylcytosine methylation changes and aberrant microRNA expressions in livers of male fetal mice. (2020) (11)
CDDO-9,11-dihydro-trifluoroethyl amide (CDDO-dhTFEA) induces hepatic cytoprotective genes and increases bile flow in rats (2013) (11)
Final report on the safety assessment of amino nitrophenols as used in hair dyes. (2009) (11)
Hepatic UDP-glucose and UDP-glucuronic acid synthesis rates in rats during a reduced energy state. (1987) (11)
Amended Safety Assessment of Sesamum Indicum (Sesame) Seed Oil, Hydrogenated Sesame Seed Oil, Sesamum Indicum (Sesame) Oil Unsaponifiables, and Sodium Sesameseedate (2011) (10)
Molybdate depletes hepatic 3-phosphoadenosine 5-phosphosulfate and impairs the sulfation of acetaminophen in rats. (1994) (10)
Lipopolysaccharide-induced down-regulation of organic anion transporting polypeptide 4 (Oatp4; Slc21a10) is independent of tumor necrosis factor-alpha, Interleukin-1beta, interleukin-6, or inducible nitric oxide synthase. (2004) (10)
Amended Safety Assessment of Methylchloroisothiazolinone and Methylisothiazolinone as Used in Cosmetics (2021) (10)
Amended Safety Assessment of Dodecylbenzenesulfonate, Decylbenzenesulfonate, and Tridecylbenzenesulfonate Salts as Used in Cosmetics (2010) (10)
Protective effects of fulvotomentosides on cadmium-induced hepatotoxicity. (1992) (10)
CYP 2 D plays a major role in berberine metabolism in liver of mice and humans (2011) (10)
Safety Assessment of Diethanolamine and Its Salts as Used in Cosmetics (2017) (10)
Safety Assessment of Isoparaffins as Used in Cosmetics (2012) (10)
Acetaminophen does not decrease hepatic 3'-phosphoadenosine 5'-phosphosulfate in mice. (1995) (10)
The differential effects of hepatotoxicants on the sulfation pathway in rats. (1991) (10)
Effect of Diethyl Ether on the Biliary Excretion of Acetaminophen 1 (1984) (10)
Molecular Regulation of Bile Acid Homeostasis (2021) (10)
Induction of metallothionein by adrenocortical steroids. (1981) (9)
Final Safety Assessment of Thiodipropionic Acid and Its Dialkyl Esters as Used in Cosmetics (2010) (9)
Activation of cAMP-Dependent Signaling Pathway Induces Mouse Organic Anion Transporting Polypeptide 2 Expression (2007) (9)
Decreased Bile-Acid Synthesis in Livers of Hepatocyte-Conditional NADPH–Cytochrome P450 Reductase–Null Mice Results in Increased Bile Acids in Serum (2014) (9)
Adaptive Hepatic and Intestinal Alterations in Mice after Deletion of NADPH-Cytochrome P450 Oxidoreductase (Cpr) in Hepatocytes (2014) (9)
The Role of Sirt1 in Bile Acid Regulation during Calorie Restriction in Mice (2015) (9)
Safety Assessment of Modified Terephthalate Polymers as Used in Cosmetics (2014) (9)
Effect of Microsomal Enzyme Inducers on the Biliary Excretion of an Exogenous Load of Bilirubin in Newborn Rats 1 (1976) (9)
Molybdate impairs glycosaminoglycan sulfation in rat cartilage. (1996) (9)
Protective effects of fulvotomentosides on acetaminophen-induced hepatotoxicity. (1992) (9)
Safety Assessment of Achillea millefolium as Used in Cosmetics (2016) (9)
Organic anion transporting polypeptides in the hepatic uptake of PBDE congeners in mice. (2011) (9)
RNA-Seq provides new insights on the relative mRNA abundance of antioxidant components during mouse liver development. (2019) (9)
First-pass effect of nalorphine in rats. (1977) (9)
Identification and Characterization of Efflux Transporters That Modulate the Subtoxic Disposition of Diclofenac and Its Metabolites (2019) (9)
Sex-, Age-, and Race/Ethnicity-Dependent Variations in Drug-Processing and NRF2-Regulated Genes in Human Livers (2020) (9)
Th 2 skewing by activation of Nrf 2 in CD 4 + T cells 1 (2012) (9)
PROFILES IN TOXICOLOGY (2000) (8)
Inducibility of glutathione S-transferases in hamsters. (1989) (8)
Induction of metallothionein by alpha-hederin. (1993) (8)
Role of rat multidrug resistance protein 2 in plasma and biliary disposition of dibromosulfophthalein after microsomal enzyme induction. (2002) (8)
Hepatic uptake of cardiac glycosides in newborn rats, rabbits and dogs. (1975) (8)
Nutritionally and chemically induced impairment of sulfate activation and sulfation of xenobiotics in vivo. (1994) (8)
Activation of PPAR&agr; decreases bile acids in livers of female mice while maintaining bile flow and biliary bile acid excretion (2018) (8)
Safety Assessment of Dimethicone Crosspolymers as Used in Cosmetics (2014) (8)
Final Report of the Amended Safety Assessment of Quaternium-15 as Used in Cosmetics (2010) (8)
Marked interanimal differences in susceptibility of Sprague-Dawley rats to diquat-induced oxidative stress in the liver: correlation with hepatic uptake of diquat. (1992) (7)
Safety Assessment of Animal- and Plant-Derived Amino Acids as Used in Cosmetics (2014) (7)
Final Report on the Safety Assessment of Piper Methysticum Leaf/Root/Stem Extract and Piper Methysticum Root Extract (2009) (7)
Safety Assessment of Dialkyl Sulfosuccinate Salts as Used in Cosmetics (2016) (7)
Glucocorticoids Increase Renal Excretion of Urate in Mice by Downregulating Urate Transporter 1 (2019) (7)
Upholding science in health, safety and environmental risk assessments and regulations. (2016) (7)
The Effects of Hepatic Microsomal Enzyme Inducers on the Pharmacokinetics of Ouabain after Portal and Systemic Administration to Rats (1995) (7)
Amended safety assessment of tall oil acid, sodium tallate, potassium tallate, and ammonium tallate. (2009) (7)
Safety Assessment of Borosilicate Glasses as Used in Cosmetics (2013) (7)
Metallothionein-I transgenic mice are not protected from gamma-radiation. (1999) (7)
Species Difference in the Plasma Disappearance and Biliary Excretion of Procaine Amide Ethobromide 1 (1972) (7)
Special Section on Drug Metabolism and the Microbiome RNA-Seq Quantification of Hepatic Drug Processing Genes in Germ-Free Mice s Felcy (2015) (7)
Intestinal biotransformation of harmol and 1-naphthol in the rat. Further evidence of dose-dependent phase-II conjugation in situ. (1991) (7)
Identification of the mixed disulfide of glutathione and cysteinylglycine in bile: dependence on gamma-glutamyl transferase and responsiveness to oxidative stress. (1992) (7)
Induction of metallothionein by superantigenic bacterial exotoxin: probable involvement of the immune system. (1994) (7)
INCREASE IN RAT LIVER UDPGLUCURONOSYLTRANSFERASE UDPGLUCURONOSYLTRANSFERASE UDPGLUCURONOSYLTRANSFERASE mRNA BY MICROSOMAL ENZYME INDUCERS THAT ENHANCE THYROID HORMONE GLUCURONIDATION (2002) (7)
Safety Assessment of Diethanolamides as Used in Cosmetics (2013) (7)
In Vivo Microdialysis Sampling of Phenol and Phenyl Glucuronide in the Blood of Unanesthetized Rainbow Trout: Implications for Toxicokinetic Studies (1993) (7)
Safety Assessment of Lecithin and Other Phosphoglycerides as Used in Cosmetics (2020) (6)
Metallothionein-I and -II knock-out mice are not more sensitive than control mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity (1999) (6)
Safety Assessment of Nylon as Used in Cosmetics (2014) (6)
Effects of ablation and activation of Nrf2 on bile acid homeostasis in mice. (2020) (6)
Effect of spironolactone on the biliary excretion and distribution of metals (1979) (6)
Effect of chlorophenoxyacetic acid herbicides on glycine conjugation of benzoic acid. (1999) (6)
INDUCTION OF DRUG-METABOLIZING ENZYMES BY GARLIC AND ALLYL SULFIDE COMPOUNDS VIA ACTIVATION OF CAR AND NRF 2 (2007) (6)
Safety Assessment of Panax spp Root-Derived Ingredients as Used in Cosmetics (2015) (6)
7 – Metals, Hepatocytes, and Toxicology (1987) (6)
Influence of phenobarbital on morphine metabolism and disposition: LC-MS/MS determination of morphine (M) and morphine-3-glucuronide (M3G) in Wistar-Kyoto rat serum, bile, and urine. (2007) (6)
In vivo microdialysis sampling of phenol and phenyl glucuronide in the blood of unanesthetized rainbow trout: implications for toxicokinetic studies. (1993) (6)
Safety Assessment of PEGs Cocamine and Related Ingredients as Used in Cosmetics (2018) (6)
Calorie Restriction Increases P-Glycoprotein and Decreases Intestinal Absorption of Digoxin in Mice (2016) (6)
Safety Assessment of Keratin and Keratin-Derived Ingredients as Used in Cosmetics (2021) (6)
Safety Assessment of Monosaccharides, Disaccharides, and Related Ingredients as Used in Cosmetics (2019) (6)
Safety Assessment of Nitrocellulose and Collodion as Used in Cosmetics (2016) (6)
Effects of molybdate and pentachlorophenol on the sulfation of α-naphthol (1999) (5)
Suppression of liver cytochrome P450 by alpha-hederin: relevance to hepatoprotection. (1995) (5)
Safety Assessment of Sorbitan Esters as Used in Cosmetics (2019) (5)
Safety Assessment of PCA (2-Pyrrolidone-5-Carboxylic Acid) and Its Salts as Used in Cosmetics (2019) (5)
Safety Assessment of Stearyl Heptanoate and Related Stearyl Alkanoates as Used in Cosmetics (2012) (5)
Elucidation of OATP1B1 and 1B3 transporter function using transgenic rodent models and commonly known single nucleotide polymorphisms. (2020) (5)
Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics (2022) (5)
Safety Assessment of Anthemis nobilis–Derived Ingredients as Used in Cosmetics (2017) (5)
Xenobiotic Receptors CAR and PXR (2010) (5)
Importance of hepatic function on the plasma disappearance and biliary excretion of hexachlorophene. (1979) (5)
Safety Assessment of Tromethamine, Aminomethyl Propanediol, and Aminoethyl Propanediol as Used in Cosmetics (2018) (5)
Suppressed farnesoid X receptor by iron overload in mice and humans potentiates iron‐induced hepatotoxicity (2021) (5)
Tissue sulfate determination by ion chromatography. (1992) (5)
Amended Safety Assessment of Hypericum Perforatum-Derived Ingredients as Used in Cosmetics (2014) (5)
Age-Related Pharmacokinetics of Ouabain in Rats 1 (1982) (5)
Safety Assessment of Silylates and Surface-Modified Siloxysilicates (2013) (5)
Effect of P-450 inducers on biliary excretion of glutathione and its hydrolysis products. Correlation between hepatic gamma-glutamyltranspeptidase activity and the proportion of glutathione hydrolysis products in bile. (1993) (5)
Safety Assessment of Formic Acid and Sodium Formate as Used in Cosmetics (2016) (4)
Final Report of the Cosmetic Ingredient Review Expert Panel On the Safety Assessment of 1,2-Glycols as Used in Cosmetics June 28, 2011 (2011) (4)
Safety Assessment of Citrus Fruit-Derived Ingredients as Used in Cosmetics (2021) (4)
Cadmium-binding proteins in rat testes: characterization and apparent source of the low-molecular-weight protein. (1987) (4)
Safety Assessment of Tin(IV) Oxide as Used in Cosmetics (2014) (4)
Tissue distribution, hormonal regulation, ontogeny, diurnal expression, and induction of mouse cystine transporters Slc3a1 and Slc7a9 (2020) (4)
Amended Safety Assessment of Chamomilla recutita-Derived Ingredients as Used in Cosmetics (2018) (4)
Long noncoding RNAs and transcription of cytochrome P450s in mouse liver during maturation (2013) (4)
Importance of Large Intestine in Regulating Bile Acids and GLP-1 in Germ-free Mice. (2015) (4)
Biliary excretion of colchicine in newborn rats. (1975) (4)
3-Hydroxylation of salicylamide in mice. (1988) (4)
Disposition of metals after portal and systemic administration to rats. (1983) (4)
Effect of microsomal enzyme inducers on carrier-mediated transport systems in isolated rat hepatocytes (1978) (4)
Effects Of Butyrate Homologues On Metallothionein Induction In Rat Primary Hepatocyte Cultures (1992) (4)
Effect of cobalt on biliary excretion of bilirubin and glutathione. (1985) (4)
Determination of Transcription Start Site and Analysis of Promoter Sequence, Splice Junction Sites, Intron Sequence and Codon Usage Bias of Rat Liver-specific Organic Anion Transporter-1 (rlst-1/Oatp-4/Slc21a10) Gene (2002) (4)
Safety Assessment of Magnesium Sulfate as Used in Cosmetics (2018) (4)
Safety Assessment of Ethanolamides as Used in Cosmetics (2015) (4)
Safety Assessment of Fatty Acid Amidopropyl Dimethylamines as Used in Cosmetics (2019) (4)
Safety Assessment of Saccharide Esters as Used in Cosmetics (2021) (4)
Safety Assessment of Rosa canina-derived Ingredients as Used in Cosmetics (2022) (4)
Safety Assessment of Synthetic Fluorphlogopite as Used in Cosmetics (2015) (4)
Safety Assessment of Monoglyceryl Monoesters as Used in Cosmetics (2020) (4)
Effect of partial hepatectomy on the expression of seven rat sulphotransferase mRNAs. (1999) (4)
Effect of thyroid hormones on liver microsomal enzyme induction in rats exposed to 2,3,7,8,-tetrachlorodibenzo-p-dioxin. (1985) (3)
Cd-metallothionein nephrotoxicity in inbred strains of mice. (1992) (3)
Hemodynamics of the Isolated Perfused Liver of Hypothyroid and Hyperthyroid Rats 1 (1969) (3)
Safety Assessment of Palmitoyl Oligopeptides as Used in Cosmetics Status : Scientific Literature Review Release (2012) (3)
Amended safety assessment of sodium picramate and picramic acid. (2009) (3)
H 1-antihistamines exacerbate high-fat diet-induced hepatic steatosis in wild-type but not in apolipoprotein E knockout mice (2014) (3)
Safety Assessment of Alkyl Ethylhexanoates as Used in Cosmetics (2015) (3)
Effect of nine diets on xenobiotic transporters in livers of mice (2015) (3)
Safety Assessment of Citrus Peel-Derived Ingredients as Used in Cosmetics (2021) (3)
Separation and quantification of isometallothioneins by high-performance liquid chromatography-atomic absorption spectrometry. (1991) (3)
Safety Assessment of Pentaerythrityl Tetraesters as Used in Cosmetics (2015) (3)
Safety Assessment of Cross-Linked Alkyl Acrylates as Used in Cosmetics (2017) (3)
Choleretic effect of structural analogs of valproic acid in the rat. (1983) (3)
Safety Assessment of Polyaminopropyl Biguanide (Polyhexamethylene Biguanide Hydrochloride) as Used in Cosmetics (2020) (3)
Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics (2021) (3)
Effect of Gender and Various Diets on Bile Acid Profile and Related Genes in Mice (2020) (3)
Safety Assessment of 2-Amino-4-Hydroxyethylaminoanisole and 2-Amino-4-Hydroxyethylaminoanisole Sulfate as Used in Cosmetics (2013) (3)
Safety Assessment of Polyquaternium-22 and Polyquarternium-39 as Used in Cosmetics (2016) (3)
Safety Assessment of Camellia sinensis–Derived Ingredients As Used in Cosmetics (2019) (3)
The biotransformation of Bupleuri Radix by human gut microbiota (2019) (3)
Evaluation of hepatic storage of sulfobromopthalein in rats and dogs (1982) (3)
Safety Assessment of Ethanolamine and Ethanolamine Salts as Used in Cosmetics (2015) (3)
Safety Assessment of Ethers and Esters of Ascorbic Acid as Used in Cosmetics (2022) (2)
Safety Assessment of Polyene Group as Used in Cosmetics (2020) (2)
Use of metallothionein-transgenic and knock-out mouse models for the study of cadmium toxicity (1998) (2)
Effect of Butylated Hydroxyanisole on Hepatic Glucuronidation and Biliary Excretion of Drugs in Mice (1988) (2)
Amended Safety Assessment of Fatty Acyl Sarcosines and Sarcosinate Salts as Used in Cosmetics (2021) (2)
Safety Assessment of Avena sativa (Oat)-Derived Ingredients As Used in Cosmetics (2019) (2)
Metallothionein-I/II null mice are sensitive to the hepatotoxicity of acetaminophen (1998) (2)
Safety Assessment of Pentaerythrityl Tetra-Di-t-Butyl Hydroxyhydrocinnamate as Used in Cosmetics (2018) (2)
Hepatic presystemic elimination of diethylstilbestrol by rats and effect of pretreatment with inducers of UDP-glucuronosyltransferase. (1985) (2)
Safety Assessment of Dialkyl Malates as Used in Cosmetics (2015) (2)
Genetically graded activation of Nrf2 protects mice against carbon tetrachloride-induced hepatotoxicity (2015) (2)
Safety Assessment of Barium Sulfate as Used in Cosmetics (2018) (2)
Amended Safety Assessment of Isethionate Salts as Used in Cosmetics (2017) (2)
Activation of Nrf2 decreases bile acid concentrations in livers of female mice (2021) (2)
Effects of Absence of Constitutive Androstane Receptor (CAR) on Bile Acid Homeostasis in Male and Female Mice. (2019) (2)
RNA-Seq unveiled section-specific host response to lack of gut microbiota in mouse intestine. (2021) (2)
Use of genetically altered animal models in understanding the role of metallothionein in cadmium toxicity (2000) (2)
Vitis Vinifera ( Grape ) Ingredients as Used in Cosmetics February 17 , 2012 (2012) (2)
Obfuscating transparency? (2018) (2)
Effects of molybdate and pentachlorophenol on the sulfation of alpha-naphthol. (1999) (2)
Effect of nine diets on mRNAs of phase-II conjugation enzymes in livers of mice (2017) (2)
Effects of molybdate and pentachlorophenol on the sulfation of dehydroepiandrosterone. (1998) (2)
Formaldehyde and Methylene Glycol October 12 , 2011 (2011) (1)
Characterization of Bile Acid homeostasis in Germ‐free Mice (2012) (1)
Safety Assessment of Monosaccharides and Disaccharides as Used in Cosmetics (2013) (1)
Safety Assessment of Skin and Connective Tissue-Derived Proteins and Peptides as Used in Cosmetics (2022) (1)
Age‐ and Gender‐Related Differences in Xenobiotic Transporter Expression (2006) (1)
Special Section on Drug Metabolism and the Microbiome Importance of Large Intestine in Regulating Bile Acids and Glucagon-Like Peptide-1 in Germ-Free Mice s (2015) (1)
Inhibition of IFN production by the nrf2 activators, tBHQ and BHA, in activated murine T cells (2008) (1)
Editorial overview (2008) (1)
Safety Assessment of Soy Peptides as Used in Cosmetics (2015) (1)
Amended Safety Assessment of Persulfates as Used in Cosmetics (2022) (1)
Effects of molybdate on the sulfation of harmol and α-naphthol (1998) (1)
The treatment of poisoning. (1980) (1)
Safety Assessment of Methyl Glucose Polyethers and Esters as Used in Cosmetics (2016) (1)
Safety Assessment of Centella asiatica-Derived Ingredients as Used in Cosmetics (2023) (1)
Induction of Hepatic Transporters Mrp3 and Mrp4 by Clofibrate is Regulated by PPAR α (2006) (1)
Tentative Amended Safety Assessment Ethanolamine and Ethanolamine Salts as Used in Cosmetics December 19 , 2011 (2011) (1)
Safety Assessment of 6-Hydroxyindole as Used in Cosmetics (2014) (1)
Safety Assessment of Citrus Flower- and Leaf-Derived Ingredients as Used in Cosmetics (2021) (1)
Absorption, Enterohepatic Circulation, and Fecal Excretion of Toxicants (2010) (1)
Safety Assessment of Hydroxypropyl Bis(N-Hydroxyethyl-p-Phenylenediamine) HCl as Used in Cosmetics (2016) (1)
Mechanisms of Drug-Induced Cholestasis (1996) (1)
Effects of the patent ductus venosus on bile acid homeostasis in aryl hydrocarbon receptor (AhR)-null mice. (2020) (1)
Safety Assessment of Citrus Plant- and Seed-Derived Ingredients as Used in Cosmetics (2021) (1)
The role of nuclear factor erythroid 2‐related factor 2 (Nrf2) in cytokine production by CD4+ T cells (2008) (1)
Effect of dosage and form of cadmium on its absorption and distribution (1986) (1)
Final Report on the Safety Assessment of PPG-2 Methyl Ether, PPG-3 Methyl Ether, and PPG-2 Methyl Ether Acetate (2009) (1)
Final Amended Safety Assessment of Sodium Sulfate as Used in Cosmetics (2021) (1)
Safety Assessment of Inorganic Hydroxides as Used in Cosmetics (2021) (1)
The Life and Times of John Doull, PhD, MD (1922-2017). (2018) (1)
Safety Assessment of Plant-Derived Proteins and Peptides as Used in Cosmetics (2022) (1)
Final Report on the Safety Assessment of Piper Methysticum Leaf/Root/Stem Extract and Piper Methysticum Root Extract (2009) (1)
Safety Assessment of Alkyl Phosphates as Used in Cosmetics (2019) (1)
BILIARY EXCRETION OF XENOBIOTICS (1981) (1)
Safety Assessment of PCA and Its Salts as Used in Cosmetics (2014) (1)
Safety Assessment of PEG-150 Pentaerythrityl Tetrastearate as Used in Cosmetics (2018) (1)
Safety Assessment of Nitrocellulose as Used in Cosmetics (2013) (1)
Final Amended Report on Safety Assessment on Aminomethyl Propanol and Aminomethyl Propanediol (2009) (1)
Safety Assessment of Bis-Diglyceryl Polyacyladipate-2 and Bis-Diglyceryl Polyacyladipate-1 as Used in Cosmetics (2013) (1)
Safety Assessment of Ceramides as Used in Cosmetics (2020) (1)
Safety Assessment of Phosphoric Acid and Its Salts as Used in Cosmetics (2021) (1)
Evaluation of hepatic storage of sulfobromophthalein in rats and dogs. (1978) (1)
Sulfated Ethoxylated Alcohols Final Report of the Amended Safety Assessment of Sodium Laureth Sulfate and Related Salts of (2010) (0)
DMD060053 1826..1833 (2014) (0)
Expression of Cyp4a10 and Pdk4 genes in the livers of mice exposed to reference compound activators of CAR, FXR, Nrf2, PPARα, and PXR. (2015) (0)
Safety Assessment of Lauriminodipropionic Acid, Sodium Lauriminodipropionate, and Disodium Lauriminodipropionate as Used in Cosmetics (2013) (0)
Final Report on the Safety Assessment of PPG-2 Methyl Ether, PPG-3 Methyl Ether, and PPG-2 Methyl Ether Acetate (2009) (0)
Genetic polymorphisms in the RNA polymerase II core promoter and enhancer elements of the UGT1A1 promoter influence activation of its gene transcription (2008) (0)
Glucuronidase resistant forms of furosemide glucuronide: Evidence for pH dependent isomerization (1984) (0)
Safety Assessment of Alkyl PEG Sulfosuccinates as Used in Cosmetics (2015) (0)
Safety Assessment of Trimellitic Anhydride Copolymers as Used in Cosmetics (2020) (0)
Immaturity of the Hepatic Excretory Function for Ouabain1 (1973) (0)
Editorial overview. Xenobiotic and endobiotic transporters: structure, function and regulation. (2008) (0)
Circulating plasma DNA in non-small cell lung cancer patients is not influenced by inflammatory pulmonary conditions (2009) (0)
Repeated administration of berberine inhibits cytochromes P450 in humans (2011) (0)
The role of Nrf2 in Th1/Th2 differentiation in CD4+ T cells (2011) (0)
Amended Final Safety Assessment Diethanolamine and its Salts as Used in Cosmetics October 17 , 2011 (2011) (0)
Safety Assessment of Trialkyl Trimellitates as Used in Cosmetics (2015) (0)
Metallothionein-null mice are susceptible to chronic CdCl2-induced nephropathy: Cd-induced renal injury is not necessarily mediated by CdMT (1999) (0)
Safety Assessment of Apple-Derived Ingredients as Used in Cosmetics (2023) (0)
[The importance of the biliary excretion of drugs in the human]. (1983) (0)
Evaluation of hepatic storage of sulfobromophthalein in rats and dogs (1978) (0)
Special Section on Bile Acids, Drug Metabolism, and Toxicity—Editorial (2022) (0)
Amended Safety Assessment of Hydroquinone (2014) (0)
XVI INTERNATIONAL SYMPOSIUM OF THE SOCIETY OF TOXICOLOGIC PATHOLOGISTS POSTER ABSTRACTS (1998) (0)
Pregnenoline-16α-carbonitrile (PCN), an effective inducer of hepatic phase II biotransformation in the rat (1981) (0)
Safety Assessment of 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate as Used in Cosmetics (2022) (0)
1565 – INCREASE IN THE BILIARY EXCRETION OF DRUGS BY MICROSOMAL ENZYME INDUCERS: ROLE OF LIGANDIN (1977) (0)
DMD065698 1505..1521 (2015) (0)
Biliary Excretion of Thiols and Their Role in Elimination of Methylmercury (1989) (0)
Safety Assessment of Eucalyptus globulus (Eucalyptus)-Derived Ingredients as Used in Cosmetics (2023) (0)
Environmental Epidemiology for Chemists (1994) (0)
Nrf2 activation suppresses production of T cell cytokines and IgM in C57BL/6 mice (90.26) (2009) (0)
Developmental regulation of nuclear receptor mRNAs in livers of FXR‐null mice (901.1) (2014) (0)
Molecular Biology of ABC Transporters (2018) (0)
In Memorium: Gabriel L. Plaa (2010) (0)
Fig . 4 Androgens Kidneys ↑ Oatp 1 a 1 → M > F ↑ Oatp 3 a 1 → M > F Livers ↑ Oatp 1 a 1 (2006) (0)
Safety Assessment of 2-Amino-3-Hydroxypyridine as Used in Cosmetics (2020) (0)
Safety Assessment of Hydroxystearic Acid as Used in Cosmetics (2015) (0)
Reduction of Thyroid Hormone Levels by Glucuronosyltransferase Inducers (1993) (0)
Effects of the Microbiome on Xenobiotic Processing Genes (2018) (0)
DMD #14845 1 GENDER DIFFERENCES IN mRNA EXPRESSION OF ABC EFFLUX AND BILE ACID TRANSPORTERS IN KIDNEY, LIVER, AND INTESTINE OF 5/6 NEPHRECTOMIZED RATS (2007) (0)
TENTATIVE SAFETY ASSESSMENT Kojic Acid as Used in Cosmetics December 8 , 2009 (2009) (0)
Editorial. (2019) (0)
Safety Assessment of Helianthus annuus (Sunflower)-Derived Ingredients as Used in Cosmetics (2023) (0)
The Nrf2 activator, tBHQ, inhibits the early production of IL‐2, but not CD69 induction, in primary murine splenocytes and human Jurkat T cells (2012) (0)
DEA Amides as Used in Cosmetics (2011) (0)
Acquired Cadmium Resistance in Metallothionein-I/II( (cid:1) / (cid:1) ) Knockout Cells: Role of the T-Type Calcium Channel Cacn (cid:1) 1G in Cadmium Uptake (2006) (0)
Final Report On the Safety Assessment of Galactomannans As Used in Cosmetics March 6 , 2012 (2012) (0)
Safety Assessment of Polyether Lanolins as Used in Cosmetics (2018) (0)
Nrf2 activation skews murine and human CD4 T cell differentiation towards a Th2 phenotype (2016) (0)
Resistance of some biotransformation pathways to hepatotoxins (1982) (0)
Effects of molybdate on the sulfation of harmol and alpha-naphthol. (1998) (0)
Mid-Atlantic Toxicology Cource (1989) (0)
Xenobiotic-Induced Hypothyroidism (2009) (0)
Age- and sex-dependent induction of liver microsomal benzo[a]pyrene hydroxylase activity in rats treated with pregnenolone-16 alpha-carbonitrile (PCN). (1985) (0)
Safety Assessment of Bisabolol as Used in Cosmetics (2015) (0)
High concentration of metallothionein in the liver of new-born rats (1978) (0)
Dialkyl Malates as Used in Cosmetics (2012) (0)
Amended Safety Assessment of Acid Violet 43 as Used in Cosmetics (2021) (0)
Safety Assessment of Hydroxyethyl-3,4-Methylenedioxyaniline HCl as Used in Cosmetics (2022) (0)
JPET #170084 Title Page Transcriptional Regulation of Renal Cytoprotective Genes by Nrf2 and its Potential Use as a Therapeutic Target to Mitigate Cisplatin-Induced Nephrotoxicity (2010) (0)
Role of Transcription Factors in the Pharmacokinetics of Xenobiotics (2009) (0)
Safety Assessment of Bovine Milk Proteins and Protein Derivatives as Used in Cosmetics (2022) (0)
Tissue distribution and ontogeny of mouse organic anion transporting polypeptides (Oatps) Department of Pharmacology, Toxicolo (2005) (0)
Amended Safety Assessment of Butyl Polyoxyalkylene Ethers as Used in Cosmetics (2022) (0)
Safety Assessment of Xylene Sulfonic Acid, Toluene Sulfonic Acid, and Alkyl Aryl Sulfonate Hydrotropes as Used in Cosmetics (2011) (0)
Safety Assessment of Isostearamidopropyl Morpholine Lactate as Used in Cosmetics (2015) (0)
Minimal role of the high concentration of hepatic metallothionein in the newborn rat in the toxicity, distribution, and excretion of cadmium. (1982) (0)
Tentative Safety Assessment Chlorphenesin as Used in Cosmetics June 22, 2012 (2012) (0)
Note Role of CYP 3 A in Isoniazid Metabolism In Vivo (2014) (0)
Safety Assessment of Hydrofluorocarbon 152a as Used in Cosmetics (2022) (0)
Biliary Excretion (1987) (0)
Safety Assessment of Cocos nucifera (Coconut)-Derived Ingredients as Used in Cosmetics (2023) (0)
Activation of Nrf2 skews CD4+ cells toward Th2 differentiation (152.15) (2011) (0)
Safety Assessment of Ammonium Hectorites as Used in Cosmetics (2013) (0)
Safety Assessment of Dimethiconol and Its Esters and Reaction Products as Used in Cosmetics (2017) (0)
The role of FXR in the regulation of phase‐I drug metabolizing gene expression during mouse liver maturation (1141.1) (2014) (0)
Safety Assessment of Carbonate Salts as Used in Cosmetics (2022) (0)
Amended Safety Assessment of Triglycerides as Used in Cosmetics (2022) (0)
Dynamic DNA and histone methylation influences the ontogeny of xenobiotic metabolizing genes during postnatal mouse liver maturation (2009) (0)
Depletion of hepatic UDP-glucuronic acid (UDPGA) decreases the biliary excretion of drugs (1982) (0)
Effect of inducers and inhibitors of glucuronidation on the choleretic action of valproic acid in the rat (1981) (0)
Final Report of the Cosmetic Ingredient Review Expert Panel Safety Assessment of Methoxyisopropanol and Methoxyisopropyl Acetate September 10 , 2004 (2004) (0)
UvA-DARE ( Digital Academic Repository ) Taxonomy and epidemiology Mucor irregularis , agent of chronic cutaneous mucormycosis (2013) (0)
Derived Cosmetic Ingredients − Calendula officinalis Final Report of the Cosmetic Ingredient Review Expert Panel Amended Safety Assessment of (2010) (0)
Extrahpetic distribution of sulfobromophthalein. (1975) (0)
Determination of hepatic uridine 5'-diphosphoglucuronic acid (UDPGA) by conjugation with dimethylstilbestrol (DES) (1981) (0)
Amended Safety Assessment of Malic Acid and Sodium Malate as Used in Cosmetics (2022) (0)
Abstract 4865: Inhibition of histone methyltransferase G9a as a promising new target for the treatment of liver cancer (2010) (0)

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