Cynthia Kenyon

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Cynthia Kenyon is affiliated with the following schools: University of Georgia, Massachusetts Institute of Technology, University of California, San Francisco

US molecular biologist

Why Is Cynthia Kenyon Influential?

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According to Wikipedia, Cynthia Jane Kenyon is an American molecular biologist and biogerontologist known for her genetic dissection of aging in a widely used model organism, the roundworm Caenorhabditis elegans. She is the vice president of aging research at Calico Research Labs, and emeritus professor of biochemistry and biophysics at the University of California, San Francisco .

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Cynthia Kenyon's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Papers

A C. elegans mutant that lives twice as long as wild type (1993) (3067)
The genetics of ageing (2010) (2397)
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans (2003) (2089)
daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. (1997) (1491)
Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor (2003) (1387)
Genetic pathways that regulate ageing in model organisms (2000) (1309)
The Plasticity of Aging: Insights from Long-Lived Mutants (2005) (1304)
The nematode Caenorhabditis elegans. (1988) (1175)
Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling (2001) (1000)
Rates of Behavior and Aging Specified by Mitochondrial Function During Development (2002) (960)
Signals from the reproductive system regulate the lifespan of C. elegans (1999) (902)
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans (2007) (800)
Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. (2002) (762)
Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan (2003) (730)
A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans (2008) (695)
Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans (2010) (548)
Regulation of lifespan by sensory perception in Caenorhabditis elegans (1999) (519)
New Genes Tied to Endocrine, Metabolic, and Dietary Regulation of Lifespan from a Caenorhabditis elegans Genomic RNAi Screen (2005) (503)
A Conserved Regulatory System for Aging (2001) (498)
DNA-damaging agents stimulate gene expression at specific loci in Escherichia coli. (1980) (480)
Regulation of Life-Span by Germ-Line Stem Cells in Caenorhabditis elegans (2002) (471)
Timing Requirements for Insulin/IGF-1 Signaling in C. elegans (2002) (461)
Comparing genomic expression patterns across species identifies shared transcriptional profile in aging (2004) (451)
Interventions to Slow Aging in Humans: Are We Ready? (2015) (450)
The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. (1995) (438)
Inhibition of Respiration Extends C. elegans Life Span via Reactive Oxygen Species that Increase HIF-1 Activity (2010) (433)
Cell Nonautonomy of C. elegans daf-2 Function in the Regulation of Diapause and Life Span (1998) (349)
Regulation of C. elegans Longevity by Specific Gustatory and Olfactory Neurons (2004) (339)
A homeotic gene cluster patterns the anteroposterior body axis of C. elegans (1993) (323)
A calcium-channel homologue required for adaptation to dopamine and serotonin in Caenorhabditis elegans (1995) (317)
Germ-Cell Loss Extends C. elegans Life Span through Regulation of DAF-16 by kri-1 and Lipophilic-Hormone Signaling (2006) (304)
Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression. (2009) (296)
The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing (2011) (290)
Inducibility of a gene product required for UV and chemical mutagenesis in Escherichia coli. (1981) (269)
The beta-catenin homolog BAR-1 and LET-60 Ras coordinately regulate the Hox gene lin-39 during Caenorhabditis elegans vulval development. (1998) (265)
Role of a New Rho Family Member in Cell Migration and Axon Guidance in C. elegans (1997) (258)
A Wnt signaling pathway controls hox gene expression and neuroblast migration in C. elegans. (1999) (258)
A gene involved in the development of the posterior body region of C. elegans (1986) (242)
Mutations That Increase the Life Span of C. elegans Inhibit Tumor Growth (2006) (230)
Spatial and Temporal Controls Target pal-1 Blastomere-Specification Activity to a Single Blastomere Lineage in C. elegans Embryos (1996) (213)
Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity (2010) (212)
Characterization of beta pat-3 heterodimers, a family of essential integrin receptors in C. elegans (1995) (211)
Analysis of a Caenorhabditis elegans Twist homolog identifies conserved and divergent aspects of mesodermal patterning. (1998) (184)
Neuronal cell migration in C. elegans: regulation of Hox gene expression and cell position. (1996) (177)
A Wnt signaling system that specifies two patterns of cell migration in C. elegans. (1999) (176)
Activation of a C. elegans Antennapedia homologue in migrating cells controls their direction of migration (1992) (175)
Expression of the E. coli uvrA gene is inducible (1981) (173)
Healthy Animals with Extreme Longevity (2003) (173)
The Hox gene lin-39 is required during C. elegans vulval induction to select the outcome of Ras signaling. (1998) (173)
Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans (2007) (171)
Direct and indirect gene regulation by a life-extending FOXO protein in C. elegans: roles for GATA factors and lipid gene regulators. (2013) (166)
A pathway that links reproductive status to lifespan in Caenorhabditis elegans (2010) (165)
DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans (2007) (159)
A Regulated Response to Impaired Respiration Slows Behavioral Rates and Increases Lifespan in Caenorhabditis elegans (2009) (155)
Spontaneous Age-Related Neurite Branching in Caenorhabditis elegans (2011) (148)
Multiple HOM-C gene interactions specify cell fates in the nematode central nervous system. (1993) (126)
New genes that extend Caenorhabditis elegans’ lifespan in response to reproductive signals (2012) (124)
Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex (2007) (120)
The Two Isoforms of the Caenorhabditis elegans Leukocyte-Common Antigen Related Receptor Tyrosine Phosphatase PTP-3 Function Independently in Axon Guidance and Synapse Formation (2005) (115)
If birds can fly, why can't we? Homeotic genes and evolution (1994) (113)
A Transcription Elongation Factor That Links Signals from the Reproductive System to Lifespan Extension in Caenorhabditis elegans (2009) (112)
A C. elegans Hox gene switches on, off, on and off again to regulate proliferation, differentiation and morphogenesis. (1996) (112)
A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells (2011) (111)
Posterior pattern formation in C. elegans involves position-specific expression of a gene containing a homeobox (1988) (110)
Identification of genes from pattern formation, tyrosine kinase, and potassium channel families by DNA amplification. (1989) (106)
Establishment of left/right asymmetry in neuroblast migration by UNC-40/DCC, UNC-73/Trio and DPY-19 proteins in C. elegans. (2000) (101)
A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage (2017) (96)
A cluster of Antennapedia-class homeobox genes in a nonsegmented animal. (1991) (92)
Regulation of the Longevity Response to Temperature by Thermosensory Neurons in Caenorhabditis elegans (2009) (90)
Regulation of the Longevity Response to Temperature by Thermosensory Neurons in Caenorhabditis elegans (2009) (90)
Roles for ROS and hydrogen sulfide in the longevity response to germline loss in Caenorhabditis elegans (2016) (88)
The Somatic Reproductive Tissues of C. elegans Promote Longevity through Steroid Hormone Signaling (2010) (87)
EGL-27 is similar to a metastasis-associated factor and controls cell polarity and cell migration in C. elegans. (1999) (80)
Genes affecting sensitivity to serotonin in Caenorhabditis elegans. (1996) (79)
Deep Proteome Analysis Identifies Age-Related Processes in C. elegans (2016) (78)
How a Mutation that Slows Aging Can Also Disproportionately Extend End-of-Life Decrepitude. (2017) (78)
MIG-13 Positions Migrating Cells along the Anteroposterior Body Axis of C. elegans (1999) (77)
Identification of genes that regulate a left-right asymmetric neuronal migration in Caenorhabditis elegans. (2003) (77)
The ire-1 ER stress-response pathway is required for normal secretory-protein metabolism in C. elegans (2013) (72)
The role of lin-22, a hairy/enhancer of split homolog, in patterning the peripheral nervous system of C. elegans. (1997) (71)
Caenorhabditis elegans integrates food and reproductive signals in lifespan determination (2007) (71)
Regulation of cellular responsiveness to inductive signals in the developing C. elegans nervous system (1991) (70)
Selective silencing of cell communication influences anteroposterior pattern formation in C. elegans (1990) (68)
Hox gene expression in a single Caenorhabditis elegans cell is regulated by a caudal homolog and intercellular signals that inhibit wnt signaling. (1999) (68)
Distinct Activities of the Germline and Somatic Reproductive Tissues in the Regulation of Caenorhabditis elegans' Longevity (2008) (65)
Patterning C. elegans: homeotic cluster genes, cell fates and cell migrations. (1994) (64)
A steroid hormone that extends the lifespan of Caenorhabditis elegans (2007) (64)
The dance of the Hox genes: patterning the anteroposterior body axis of Caenorhabditis elegans. (1997) (60)
egl-27 generates anteroposterior patterns of cell fusion in C. elegans by regulating Hox gene expression and Hox protein function. (1999) (60)
Ponce d'elegans: Genetic Quest for the Fountain of Youth (1996) (57)
Regulation of damage-inducible genes in Escherichia coli. (1982) (56)
A perfect vulva every time: Gradients and signaling cascades in C. elegans (1995) (54)
Stimulation of Movement in a Quiescent, Hibernation-Like Form of Caenorhabditis elegans by Dopamine Signaling (2009) (51)
Cell contact regulates neuroblast formation in the Caenorhabditis elegans lateral epidermis. (1994) (51)
Specification of anteroposterior cell fates in Caenorhabditis elegans by Drosophila Hox proteins (1995) (50)
Multiple levels of regulation specify the polarity of an asymmetric cell division in C. elegans. (2000) (50)
Reversible Age-Related Phenotypes Induced during Larval Quiescence in C. elegans. (2016) (48)
The roles of two C. elegans HOX co-factor orthologs in cell migration and vulva development (2005) (47)
Environmental Factors and Gene Activities That Influence Life Span (1997) (46)
REF-1, a protein with two bHLH domains, alters the pattern of cell fusion in C. elegans by regulating Hox protein activity. (2001) (45)
Expression of the homeotic gene mab-5 during Caenorhabditis elegans embryogenesis. (1992) (45)
Correct Hox gene expression established independently of position in Caenorhabditis elegans (1996) (44)
Isolation of actin‐associated proteins from Caenorhabditis elegans oocytes and their localization in the early embryo (1997) (44)
The zinc finger protein REF-2 functions with the Hox genes to inhibit cell fusion in the ventral epidermis of C. elegans. (2002) (42)
Impact papers on aging in 2009 (2010) (40)
Two wnt genes in Caenorhabditis elegans. (1993) (38)
A Shift to Organismal Stress Resistance in Programmed Cell Death Mutants (2013) (36)
The naked truth: a comprehensive clarification and classification of current ‘myths’ in naked mole‐rat biology (2021) (33)
The thrombospondin repeat containing protein MIG-21 controls a left-right asymmetric Wnt signaling response in migrating C. elegans neuroblasts. (2012) (30)
Analysis of mRNA synthesis following induction of the Escherichia coli SOS system. (1984) (30)
Micro‐proteomics with iterative data analysis: Proteome analysis in C. elegans at the single worm level (2016) (27)
Genes That Act Downstream of Sensory Neurons to Influence Longevity, Dauer Formation, and Pathogen Responses in Caenorhabditis elegans (2012) (26)
X Chromosome Domain Architecture Regulates Caenorhabditis elegans Lifespan but Not Dosage Compensation. (2019) (25)
Enrichment of regulatory motifs upstream of predicted DAF-16 targets (2006) (24)
Cell signals allow the expression of a pre-existent neural pattern in C. elegans. (1992) (24)
The bacterial response to DNA damage (1983) (24)
Pediatric emergency care capacity in a low-resource setting: An assessment of district hospitals in Rwanda (2017) (21)
Some signal developments (1990) (21)
A Role for Autophagy Genes in the Extension of Lifespan by Dietary Restriction in C. elegans (2005) (21)
Regulation and functions of Escherichia coli genes induced by DNA damage. (1982) (20)
Correlates of Performance of Healthcare Workers in Emergency, Triage, Assessment and Treatment plus Admission Care (ETAT+) Course in Rwanda: Context Matters (2016) (20)
The genetics of ageing (2010) (19)
Cell lineage and the control of Caenorhabditis elegans development (1985) (19)
Mutagenesis and other responses induced by DNA damage in Escherichia coli. (1982) (18)
Developing Workforce Capacity in Public Health Informatics: Core Competencies and Curriculum Design (2018) (15)
Ras proteins. Some signal developments. (1990) (11)
Regulation and function of cellular gene products involved in UV and chemical mutagenesis in E. coli. (1983) (11)
Impact papers on aging in 2009 - eScholarship (2010) (11)
Partial reprogramming restores youthful gene expression through transient suppression of cell identity (2021) (9)
Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules That Affect Aging Pathways and Extend Caenorhabditis elegans’ Lifespan (2019) (9)
Application of Transcriptional Gene Modules to Analysis of Caenorhabditis elegans’ Gene Expression Data (2020) (8)
Novel insights from a multiomics dissection of the Hayflick limit (2022) (8)
Mutagenesis and cellular responses to DNA damage. (1982) (7)
Split-wrmScarlet and split-sfGFP: tools for faster, easier fluorescent labeling of endogenous proteins in Caenorhabditis elegans (2020) (7)
Cellular dialogs during development (1989) (7)
Developmental Timekeeping: Marking time with antisense (1994) (6)
Could a hormone point the way to life extension? (2012) (6)
My adventures with genes from the fountain of youth. (2004) (6)
DNA-damaging agents stimulate gene expression at specific loci in Escherichia coli. 1980. (2005) (6)
A genetic screen identifies new steps in oocyte maturation that enhance proteostasis in the immortal germ lineage (2020) (5)
Pattern, symmetry and surprises in the development of Caenorhabditis elegans (1983) (4)
Developing and implementing a novel mentorship model (4+ 1) for maternal, newborn and child health in Rwanda (2020) (4)
Inducibility ofageneproduct required forUV andchemical mutagenesis inEscherichia coli (1981) (3)
Myeloperoxidase, a Leukocyte-Derived Vascular (2002) (3)
The complete cell atlas of an aging multicellular organism (2022) (3)
Addendum: A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage (2020) (3)
Sydney Brenner (1927–2019) (2019) (3)
The mTOR Target S6 Kinase Arrests Development in Caenorhabditis elegans When the Heat-Shock Transcription Factor Is Impaired (2018) (3)
Impact of a Multifaceted Intervention to Improve Emergency Care on Newborn and Child Health Outcomes in Rwanda. (2021) (3)
Regulation of Longevity by Insulin/Igf-1 Signaling, Sensory Neurons and the Germline in the Nematode C. Elegans (2001) (2)
A Conserved Regulatory System Minireview for Aging (2001) (2)
Reframed teacher leadership: A narrative inquiry (2008) (2)
Diverse partial reprogramming strategies restore youthful gene expression and transiently suppress cell identity. (2022) (2)
Developing and implementing a model of equitable distribution of mentorship in districts with spatial inequities and maldistribution of human resources for maternal and newborn care in Rwanda (2021) (2)
QnAs with Cynthia Kenyon. (2011) (1)
The C. elegans Observatory: High-throughput exploration of behavioral aging (2022) (1)
Mentors’ perspectives on strengths and weaknesses of a novel clinical mentorship programme in Rwanda: a qualitative study (2021) (1)
A Genetic Control Circuit for Aging (2011) (1)
Revisiting the Hayflick Limit: Insights from an Integrated Analysis of Changing Transcripts, Proteins, Metabolites and Chromatin (2021) (1)
Silencing the ASI gustatory neuron pair extends lifespan (2018) (1)
Sexist ads (1986) (1)
Step by step guide to tag endogenous genes with split-wrmScarlet and/or split-sfGFP in C. elegans v1 (2019) (0)
Long-Lived Worms (2002) (0)
(din gene/recA/lexA regulation/operon fusion/SOS functions/uvrA) (0)
K Faculty (2017) (0)
A genetic screen identifies processes that couple oocyte maturation to proteostasis in the immortal C. elegans germ lineage (2020) (0)
Thehomeoboxgene Phox 2 b is essential for the developmentof autonomic neural crest derivatives (1999) (0)
A resource for analyzing C. elegans’ gene expression data using transcriptional gene modules and module-weighted annotations (2019) (0)
A Well-Studied Worm: The Nematode Caenorhabditis elegans. (1989) (0)
Regulation de l'expression genetique conditionnelle par arn interference (2003) (0)
In Brief (2006) (0)
Activation of a C. elegans Antennapedia homologue in migrating cells controls their direction of movement (1992) (0)
Step by step guide to tag endogenous genes with split-wrmScarlet and/or split-sfGFP in C. elegans v2 (2022) (0)
Rescue of a developmental arrest caused by a C. elegans heat-shock transcription-factor mutation by loss of ribosomal S6-kinase activity (2018) (0)
Silencing the ASI gustatory neuron pair increases expression of the stress-resistance gene sod-3 in a daf-16 and daf-3 independent manner (2018) (0)
The 2002 Genetics Society of America Medal Andrew Fire (2003) (0)
Contents: Proteomics 3'16. (2016) (0)
MY FAVOURITE PAPER (2005) (0)
REGULATION AND FUNCTIONS OF Escherichia coli GENES (1982) (0)
Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules that Affect Aging Pathways and Extend C. elegans’ Lifespan (2019) (0)
Inferring weighted gene annotations from expression data (2016) (0)
FOX-O and Aging across Organisms (2010) (0)
Angiotensinogen; the key to programming female hypertension? (2003) (0)
Genes From the Fountain of Youth (2008) (0)
Heterochronic mutations of Caenorhabditis elegans their developmental and evolutionary significance (1985) (0)
pathway for ageing The first long-lived mutants : discovery of the insulin / IGF-1 (2010) (0)
Effects of glucose feeding on C. elegans lifespan and its implication in metabolic syndrome (2009) (0)

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Other Resources About Cynthia Kenyon

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What Schools Are Affiliated With Cynthia Kenyon?

Cynthia Kenyon is affiliated with the following schools: