Cynthia Selassie
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American chemist
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Chemistry
Cynthia Selassie's Degrees
- Bachelors Chemistry University of California, Berkeley
Why Is Cynthia Selassie Influential?
(Suggest an Edit or Addition)According to Wikipedia, Cynthia Rachel D. Selassie is an American bio-organic and medicinal chemist known for her work with quantitative structure-activity relationships . She is the Blanche and Frank R. Seaver Professor of Science and professor of chemistry at Pomona College in Claremont, California.
Cynthia Selassie's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Chem-bioinformatics: comparative QSAR at the interface between chemistry and biology. (2002) (186)
- History of Quantitative Structure–Activity Relationships (2010) (142)
- Thiopurine methyltransferase. Aromatic thiol substrates and inhibition by benzoic acid derivatives. (1983) (91)
- Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study. (2005) (87)
- Comparative QSAR and the radical toxicity of various functional groups. (2002) (74)
- On the toxicity of phenols to fast growing cells. A QSAR model for a radical-based toxicity (1999) (69)
- The relative toxicity of substituted phenols reported in cigarette mainstream smoke. (2002) (69)
- Phenol toxicity in leukemia cells: a radical process? (1998) (66)
- Mechanism of toxicity of esters of caffeic and dihydrocaffeic acids. (2001) (56)
- Thiopurine methyltransferase: structure-activity relationships for benzoic acid inhibitors and thiophenol substrates. (1986) (52)
- Structure-activity relationships of antineoplastic agents in multidrug resistance. (1990) (48)
- QSAR: then and now. (2002) (48)
- On the optimization of hydrophobic and hydrophilic substituent interactions of 2,4-diamino-5-(substituted-benzyl)pyrimidines with dihydrofolate reductase. (1991) (48)
- Crystallography, quantitative structure-activity relationships, and molecular graphics in a comparative analysis of the inhibition of dihydrofolate reductase from chicken liver and Lactobacillus casei by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazine s. (1984) (36)
- The use of crystallography, graphics, and quantitative structure--activity relationships in the analysis of the papain hydrolysis of X-phenyl hippurates. (1982) (36)
- Quantitative structure-activity relationship of triazine-antifolate inhibition of Leishmania dihydrofolate reductase and cell growth. (1987) (35)
- On the structure selectivity problem in drug design. A comparative study of benzylpyrimidine inhibition of vertebrate and bacterial dihydrofolate reductase via molecular graphics and quantitative structure-activity relationships. (1989) (31)
- Toxicology of benzyl alcohols: a QSAR analysis. (2000) (25)
- QSAR for the cytotoxicity of 2-alkyl or 2,6-dialkyl, 4-X-phenols: the nature of the radical reaction (2002) (24)
- Comparison of triazines as inhibitors of L1210 dihydrofolate reductase and of L1210 cells sensitive and resistant to methotrexate. (1986) (23)
- Synthesis, cytotoxicity, and QSAR analysis of X-thiophenols in rapidly dividing cells. (2003) (20)
- MOLECULAR ORBITAL PARAMETERS AND COMPARATIVE QSAR IN THE ANALYSIS OF PHENOL TOXICITY TO LEUKEMIA CELLS (1998) (19)
- Inhibition of chicken liver dihydrofolate reductase by 5-(substituted benzyl)-2,4-diaminopyrimidines. A quantitative structure-activity relationship and graphics analysis (1986) (18)
- QSAR of toxicology of substituted phenols (2015) (15)
- Quantitative structure-activity relationships of 2, 4-diamino-5-(2-X-benzyl)pyrimidines versus bacterial and avian dihydrofolate reductase. (1998) (15)
- Measurements of ionization constants and partition coefficients of quanazole prodrugs. (1982) (15)
- Quantitative structure-activity relationship of antifolate inhibition of bacteria cell cultures resistant and sensitive to methotrexate. (1985) (11)
- Quantitative structure-activity relationships of the inhibition of Pneumocystis carinii dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(X-phenyl)-s-triazines. (1995) (10)
- Quantitative Structure–Activity Relationship – A Historical Perspective and the Future (2007) (10)
- Inhibition of neutrophil elastase and thrombin activity by caffeic acid esters. (2005) (10)
- Comparative structure-activity relationships of antifolate triazines inhibiting murine tumor cells sensitive and resistant to methotrexate. (1984) (9)
- Comparison of quantitative structure-activity relationships of the inhibition of leukemia cells in culture with the inhibition of dihydrofolate reductase from leukemia cells and other cell types. (1982) (9)
- Separation of electronic and hydrophobic effects for the papain hydrolysis of substituted N-benzoylglycine esters. (1991) (8)
- A comparison of the inhibition of growth of methotrexate-resistant and -sensitive leukemia cells in culture by triazines. Evidence for a new mechanism of cell resistance to methotrexate. (1982) (7)
- Inhibition by 5-(substituted-benzyl)-2,4-diaminopyrimidines of murine tumor (L5178Y) cell cultures sensitive to and resistant to methotrexate. Further evidence for the sensitivity of resistant cells to hydrophobic drugs. (1982) (4)
- QSAR: Then and Now (2003) (4)
- Trypsin hydrolysis of X-phenyl hippurates. (1988) (2)
- Inhibition of chicken liver dihydrofolate reductase by 5-(substituted benzyl)-2,4-diaminopyrimidines. A quantitative structure-activity relationship and graphics analysis. (1986) (2)
- The mass spectra of some derivatives of 3,5‐diamino‐1,2,4‐triazole (1981) (1)
- COMPARISON OF QUANTITATIVE STRUCTURE‐ACTIVITY RELATIONSHIPS OF THE INHIBITION OF LEUKEMIA CELLS IN CULTURE WITH THE INHIBITION OF DIHYDROFOLATE REDUCTASE FROM LEUKEMIA CELLS AND OTHER CELL TYPES (1982) (0)
- A COMPARISON OF THE INHIBITION OF GROWTH OF METHOTREXATE‐RESISTANT AND ‐SENSITIVE LEUKEMIA CELLS IN CULTURE BY TRIAZINES. EVIDENCE FOR A NEW MECHANISM OF CELL RESISTANCE TO METHOTREXATE (1982) (0)
- CRYSTALLOGRAPHY, QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS, (QSAR) AND MOLECULAR GRAPHICS IN A COMPARATIVE ANALYSIS OF THE INHIBITION OF DIHYDROFOLATE REDUCTASE FROM CHICKEN LIVER AND LACTOBACILLUS CASEI BY 4,6-DIAMINO-1,2-DIHYDRO (1984) (0)
- ChemInform Abstract: Comparative QSAR and the Radical Toxicity of Various Functional Groups (2002) (0)
- The effect of ortho substitution of the 2,4-diamino- 5-(x-benzyl) pyrimidine nucleus on the inhibition of avian and bacterial dihydrofolate reductase (1993) (0)
- SYNTHESIS AND EVALUATION OF GUANAZOLE PRODRUGS AS ANTINEOPLASTIC AGENTS (1982) (0)
- Chem-Bioinformatics: Comparative QSAR at the Interface Between Chemistry and Biology (2010) (0)
- COMPARATIVE STRUCTURE-ACTIVITY RELATIONSHIPS OF ANTIFOLATE TRIAZINES INHIBITING MURINE TUMOR CELLS SENSITIVE AND RESISTANT TO METHOTREXATE (1984) (0)
- INHIBITION BY 5-(SUBSTITUTED-BENZYL)-2,4-DIAMINOPYRIMIDINES OF MURINE TUMOR (L5178Y) CELL CULTURES SENSITIVE TO AND RESISTANT TO METHOTREXATE. FURTHER EVIDENCE FOR THE SENSITIVITY OF RESISTANT CELLS TO HYDROPHOBIC DRUGS (1982) (0)
- Structure Activity Relationships of Novel Triazine Antifolates (1986) (0)
- Chapter 7:Modeling Chemical Structure-Log P (2011) (0)
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