Cynthia Wolberger

Cynthia Wolberger's AcademicInfluence.com Rankings

Cynthia Wolberger

Physics

#6061

World Rank

#7964

Historical Rank

#1702

USA Rank

Biophysics

#300

World Rank

#312

Historical Rank

#53

USA Rank

physics Degrees

Cynthia Wolberger

Biology

#11967

World Rank

#15411

Historical Rank

#2602

USA Rank

Molecular Biology

#2370

World Rank

#2407

Historical Rank

#241

USA Rank

biology Degrees

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Physics
Biology

Cynthia Wolberger's Degrees

PhD Biophysics University of California, Berkeley
Bachelors Chemistry University of California, Berkeley

Why Is Cynthia Wolberger Influential?

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According to Wikipedia, Cynthia Wolberger is an American structural biologist currently at Johns Hopkins University School of Medicine and an Elected Fellow of the American Association for the Advancement of Science. On April 19, 2019, she was elected as a member of the National Academy of Science among 100 new members and 25 foreign associates.

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Cynthia Wolberger's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells (2006) (1084)
Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. (2007) (834)
A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family. (2000) (740)
The biochemistry of sirtuins. (2006) (691)
A standard reference frame for the description of nucleic acid base-pair geometry. (2001) (549)
New insights into ubiquitin E3 ligase mechanism (2014) (516)
Crystal structure of a MATα2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions (1991) (438)
Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme. (2005) (414)
Regulated nucleosome mobility and the histone code (2004) (383)
Mms2–Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation (2006) (339)
Structure of a HoxB1–Pbx1 Heterodimer Bound to DNA Role of the Hexapeptide and a Fourth Homeodomain Helix in Complex Formation (1999) (335)
Recognition of specific DNA sequences. (2001) (312)
Molecular Insights into Polyubiquitin Chain Assembly Crystal Structure of the Mms2/Ubc13 Heterodimer (2001) (310)
The Structure of GABPα/β: An ETS Domain- Ankyrin Repeat Heterodimer Bound to DNA (1998) (293)
Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme (2006) (258)
Crystal Structure of the MATa1/MATα2 Homeodomain Heterodimer Bound to DNA (1995) (238)
Structure of a Sir2 enzyme bound to an acetylated p53 peptide. (2002) (232)
How does the histone code work? (2005) (221)
Structural basis for ligand-regulated oligomerization of AraC. (1997) (206)
Structural studies of Ets-1/Pax5 complex formation on DNA. (2001) (204)
Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posterior. (2003) (195)
Extracellular Nampt Promotes Macrophage Survival via a Nonenzymatic Interleukin-6/STAT3 Signaling Mechanism* (2008) (194)
Structural Insights into the Assembly and Function of the SAGA Deubiquitinating Module (2010) (191)
Structural basis for histone H2B deubiquitination by the SAGA DUB module (2016) (188)
A conserved catalytic residue in the ubiquitin‐conjugating enzyme family (2003) (181)
N-Lysine Propionylation Controls the Activity of Propionyl-CoA Synthetase* (2007) (178)
The Substrate Specificity of Sirtuins. (2016) (174)
RNF4-Dependent Hybrid SUMO-Ubiquitin Chains Are Signals for RAP80 and Thereby Mediate the Recruitment of BRCA1 to Sites of DNA Damage (2012) (169)
Crystal structure and solution NMR studies of Lys48-linked tetraubiquitin at neutral pH. (2007) (165)
Structure of a phage 434 Cro/DNA complex (1988) (159)
The mechanism of OTUB1 inhibition of ubiquitination (2012) (140)
A core nucleosome surface crucial for transcriptional silencing (2002) (139)
Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia. (2015) (138)
Structural basis for the mechanism and regulation of Sir2 enzymes. (2004) (135)
Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1. (2009) (134)
Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L (2019) (133)
Structure of the C‐terminal domain of Tup1, a corepressor of transcription in yeast (2000) (130)
Insights into the sirtuin mechanism from ternary complexes containing NAD+ and acetylated peptide. (2006) (126)
Multiprotein-DNA complexes in transcriptional regulation. (1999) (118)
Preprints for the life sciences (2016) (117)
The structure and conformation of Lys63-linked tetraubiquitin. (2009) (114)
Structural insights into intermediate steps in the Sir2 deacetylation reaction. (2008) (107)
The structural basis of sirtuin substrate affinity. (2006) (91)
Structural Analysis of the Autoinhibition of Ets-1 and Its Role in Protein Partnerships* (2002) (90)
E2 ubiquitin conjugating enzymes regulate the deubiquitinating activity of OTUB1 (2013) (89)
A spectrophotometric assay for conjugation of ubiquitin and ubiquitin-like proteins. (2011) (84)
Homeodomain interactions. (1996) (81)
The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA. (1998) (81)
A Multilaboratory Comparison of Calibration Accuracy and the Performance of External References in Analytical Ultracentrifugation (2015) (75)
Structure of phage 434 Cro protein at 2.35 A resolution. (1989) (66)
A Tunable Brake for HECT Ubiquitin Ligases. (2017) (66)
A Hoogsteen base pair embedded in undistorted B-DNA. (2002) (65)
A ubiquitin-dependent signaling axis specific for ALKBH-mediated DNA dealkylation repair (2017) (64)
Crystal structure of the MATa1/MAT alpha 2 homeodomain heterodimer bound to DNA. (1995) (63)
The Bromodomain of Gcn5 Regulates Site Specificity of Lysine Acetylation on Histone H3* (2014) (63)
Palladium prompted on-demand cysteine chemistry for the synthesis of challenging and uniquely modified proteins (2018) (62)
Architectural Organization of the Metabolic Regulatory Enzyme Ghrelin O-Acyltransferase* (2013) (61)
Combinatorial transcription factors. (1998) (60)
A conserved asparagine plays a structural role in ubiquitin-conjugating enzymes (2013) (60)
The 1.6 A crystal structure of the AraC sugar-binding and dimerization domain complexed with D-fucose. (1997) (59)
Structural basis for COMPASS recognition of an H2B-ubiquitinated nucleosome (2019) (59)
SIR2 family of NAD(+)-dependent protein deacetylases. (2002) (59)
Structure-based Mechanism of ADP-ribosylation by Sirtuins* (2009) (55)
A new chapter in the transcription SAGA. (2011) (54)
Chemical Synthesis of Phosphorylated Histone H2A at Tyr57 Reveals Insight into the Inhibition Mode of the SAGA Deubiquitinating Module. (2016) (52)
Measuring DNA mechanics on the genome scale (2020) (50)
Insights into binding cooperativity of MATa1/MATα2 from the crystal structure of a MATa1 homeodomain‐maltose binding protein chimera (2003) (49)
The crystal structure of the tumor suppressor protein pp32 (Anp32a): Structural insights into Anp32 family of proteins (2007) (48)
Characterization of the N-terminal Domain of the Yeast Transcriptional Repressor Tup1 (2000) (45)
Nucleosome competition reveals processive acetylation by the SAGA HAT module (2015) (43)
Structural and functional studies of the Rap1 C-terminus reveal novel separation-of-function mutants. (2008) (43)
Crystal structure of the MATa1/MATalpha2 homeodomain heterodimer in complex with DNA containing an A-tract. (1998) (42)
Structural basis for acyl-group discrimination by human Gcn5L2 (2016) (39)
Altered DNA Recognition and Bending by Insertions in the α2 Tail of the Yeast a1/α2 Homeodomain Heterodimer (1995) (39)
NMR studies of the pbx1 TALE homeodomain protein free in solution and bound to DNA: proposal for a mechanism of HoxB1-Pbx1-DNA complex assembly. (1999) (36)
Active site alanine mutations convert deubiquitinases into high‐affinity ubiquitin‐binding proteins (2018) (35)
Total chemical synthesis of SUMO-2-Lys63-linked diubiquitin hybrid chains assisted by removable solubilizing tags† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc00488e Click here for additional data file. (2017) (34)
A role for intersubunit interactions in maintaining SAGA deubiquitinating module structure and activity. (2012) (34)
Activation and regulation of H2B-Ubiquitin-dependent histone methyltransferases. (2019) (32)
Enzymatic Analysis of PTEN Ubiquitylation by WWP2 and NEDD4-1 E3 Ligases. (2016) (31)
Mechanisms for regulating deubiquitinating enzymes (2014) (30)
Characterization of the oligomeric states of wild type and mutant AraC. (2000) (30)
Transcription factor structure and DNA binding (1993) (29)
Side chain specificity of ADP‐ribosylation by a sirtuin (2009) (28)
Role of a non-canonical surface of Rad6 in ubiquitin conjugating activity (2015) (28)
Molecular Biology : Principles of Genome Function (2010) (26)
Highly cooperative recruitment of Ets-1 and release of autoinhibition by Pax5. (2009) (26)
Hydrazide Mimics for Protein Lysine Acylation To Assess Nucleosome Dynamics and Deubiquitinase Action. (2018) (24)
Structure of Sir2Tm bound to a propionylated peptide (2011) (24)
New perch for the winged helix (2000) (23)
OTUB1 non-catalytically stabilizes the E2 ubiquitin-conjugating enzyme UBE2E1 by preventing its autoubiquitination (2018) (23)
Biotinylation of lysine method identifies acetylated histone H3 lysine 79 in Saccharomyces cerevisiae as a substrate for Sir2 (2012) (22)
Characterization of the SUMO-Binding Activity of the Myeloproliferative and Mental Retardation (MYM)-Type Zinc Fingers in ZNF261 and ZNF198 (2014) (22)
Getting a grip on O-acetyl-ADP-ribose (2005) (20)
Alternate deacylating specificities of the archaeal sirtuins Sir2Af1 and Sir2Af2 (2014) (19)
FACT and Ubp10 collaborate to modulate H2B deubiquitination and nucleosome dynamics (2018) (18)
RAP80, ubiquitin and SUMO in the DNA damage response (2017) (17)
Uncovering the role of Sgf73 in maintaining SAGA deubiquitinating module structure and activity. (2015) (15)
Insights into nonspecific binding of homeodomains from a structure of MATα2 bound to DNA (2003) (13)
Recognition of ubiquitinated nucleosomes. (2017) (12)
Structure of the yeast Bre1 RING domain (2015) (12)
Structural and Thermodynamic Characterization of the DNA Binding Properties of a Triple Alanine Mutant of MATα2 (2002) (11)
How structural biology transformed studies of transcription regulation (2021) (10)
The Structure and conformation of Lys-63 linked tetraubiquitin (2009) (10)
A Tunable Brake for HECT Ubiquitin Ligases Graphical (9)
Role of E2-RING Interactions in Governing RNF4-Mediated Substrate Ubiquitination. (2016) (9)
Semisynthesis of ubiquitinated histone H2B with a native or nonhydrolyzable linkage. (2019) (8)
Crystallization and preliminary X-ray diffraction studies of a MATα2-DNA complex (1991) (8)
STRUCTURE OF PHAGE 434 CRO PROTEIN AT 2.35 ANGSTROMS RESOLUTION (1989) (7)
Recognition of DNA sequences by the repressor of bacteriophage 434. (1988) (7)
Structural Insights into Intermediate Steps in the Sir 2 Deacetylation Reaction (6)
Crystallization and preliminary X‐ray diffraction studies of an a1/α2/DNA ternary complex (1995) (6)
A new RING tossed into an old HAT. (2013) (6)
Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment. (2017) (6)
Arm–domain interactions can provide high binding cooperativity (2004) (6)
Structural and thermodynamic characterization of the DNA binding properties of a triple alanine mutant of MATalpha2. (2002) (5)
b/HLH without the zip (1994) (5)
A quantitative analysis of histone methylation and acetylation isoforms from their deuteroacetylated derivatives: application to a series of knockout mutants. (2013) (5)
Potent macrocycle inhibitors of the human SAGA deubiquitinating module (2021) (5)
Not just Salk (2017) (5)
Altered DNA recognition and bending by insertions in the alpha 2 tail of the yeast a1/alpha 2 homeodomain heterodimer. (1995) (5)
Multistate structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosome (2022) (4)
The ASCC2 CUE domain in the ALKBH3–ASCC DNA repair complex recognizes adjacent ubiquitins in K63-linked polyubiquitin (2021) (4)
Erratum: A conserved catalytic residue in the ubiquitin-conjugating enzyme family (EMBO Journal (2003) 22 (5241-5250) doi: 10.1093/emboj/cdg501) (2004) (4)
ReviewRecognition of Specific DNA Sequences teins that mediate recombination , DNA cleavage , meth - (2001) (4)
Comparison of cross-regulation by different OTUB1-E2 complexes. (2020) (4)
Biochemistry: Sirtuin on a high-fat diet (2013) (4)
Corrigendum to “The Structure and Conformation of Lys63-Linked Tetraubiquitin” [J. Mol. Biol. 392 (2009) 1117–1124] (2014) (3)
Competition Assay for Measuring Deubiquitinating Enzyme Substrate Affinity. (2018) (3)
Deubiquitinating Module Structural Insights into the Assembly and Function of the SAGA (2014) (3)
Crystallization and X-ray diffraction studies of a 434 Cro-DNA complex. (1987) (3)
Proteins: histones and chromatin. (2011) (2)
A New DUB Makes Linear Ubiquitin a Party to Its Own Destruction (2013) (2)
Structure and DNA binding of the yeast MAT alpha 2 homeodomain. (1993) (2)
How does the histone code work ? 1 (2005) (2)
On the Structural Basis of Sirtuin Substrate Affinity (2006) (2)
Identification of a new nicotinamide binding site in a sirtuin: a reassessment. (2007) (2)
Recognition of DNA sequences by the repressor and Cro proteins of bacteriophage 434 (1988) (1)
MATALPHA2 HOMEODOMAIN BOUND TO DNA (2002) (1)
Ubiquitin Conjugating Enzyme, Ubc13 (2001) (1)
Active site alanine substitutions can convert deubiquitinating enzymes into avid ubiquitin-binding domains (2017) (1)
Structure and DNA binding of the yeast MATα2 homeodomain (1993) (1)
Structure of Bre1 RING domain (2015) (1)
Crystallization and preliminary X-ray diffraction studies of an a1/alpha 2/DNA ternary complex. (1995) (1)
Crystallization and preliminary X-ray diffraction studies of a MAT alpha 2-DNA complex. (1991) (1)
Crystal structure and functional analysis of the Rap1 C‐terminus: Insights into transcriptional silencing and telomere length regulation (2007) (1)
Protein-nucleic acid interactions (2002) (1)
Structural basis for acyl group discrimination by human Gcn5L2 (2016) (1)
A role for inter-subunit interactions in maintaining SAGA deubiquitinating module structure and activity (2012) (1)
Yeast COMPASS in complex with a ubiquitinated nucleosome (2020) (0)
Substrate Recognition of Histone H2B by DUBm (2011) (0)
Crystal Structure of HoxA9 and Pbx1 homeodomains bound to DNA (2003) (0)
Spotlights on our sister journals: ChemistryOpen 2/2016 (2016) (0)
The ASCC2 CUE domain contacts adjacent ubiquitins to recognize K63-linked polyubiquitin (2021) (0)
Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell Colony Enhancing Factor 1 (2006) (0)
Crystallization of Protein–DNA Complexes (2001) (0)
Genome Wide Measurements of the Sequence Dependence of Nucleosomal DNA Flexibility (2018) (0)
Active state Dot1L bound to the H2B-Ubiquitinated nucleosome, 1-to-1 complex (2019) (0)
Active state Dot1L bound to the H2B-Ubiquitinated nucleosome, 2-to-1 complex (2019) (0)
PTEN Regulation by WWP2 (2017) (0)
SAGA DUB module Ubp8/Sgf11/Sus1/Sgf73 bound to ubiqitinated nucleosome (2016) (0)
Supplemental Information Mutations that Allow SIR 2 Orthologs to Function in a NAD +-Depleted Environment (2017) (0)
PBX1, HOMEOBOX PROTEIN HOX-B1/DNA TERNARY COMPLEX (1999) (0)
Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell Colony Enhancing Factor in Complex with Nicotinamide Mononuleotide (2006) (0)
Sir2-S-alkylamidate complex crystal structure (2008) (0)
Palladium prompted on-demand cysteine chemistry for the synthesis of challenging and uniquely modified proteins (2018) (0)
Mms2/Ubc13 Ubiquitin Conjugating Enzyme Complex (2001) (0)
Human Gcn5 bound to propionyl-CoA (2016) (0)
Crystal Structure of the MATa1/MATalpha2-3A Heterodimer Bound to DNA Complex (2002) (0)
Structure of Rad6~Ub (2015) (0)
MOUSE GABP ALPHA/BETA DOMAIN BOUND TO DNA (1998) (0)
Regulation of WWP2 ubiquitin ligase (2017) (0)
Ets-1(331-440)+GGAA duplex (2002) (0)
Structure of the yeast a1/α2 homeodomain heterodimer bound to dna (1996) (0)
The structure of h/ceOTUB1-ubiquitin aldehyde-UBCH5B~Ub (2012) (0)
MAT A1/ALPHA2/DNA TERNARY COMPLEX (1998) (0)
The mechanism of cross-talk between histone H2B ubiquitination and H3 methylation by Dot1L (2018) (0)
Sir2 bound to acetylated peptide (2009) (0)
The structure of Sir2Af1 bound to a succinylated histone peptide (2014) (0)
Protein Synthesis (2016) (0)
CRYSTAL STRUCTURE OF AN INHIBITED FRAGMENT OF Ets-1 (2002) (0)
The SAGA HAT module is tethered by its SWIRM domain and modulates activity of the SAGA DUB module (2022) (0)
Structure of yeast SAGA DUBm with Sgf73 N59D mutant at 2.36 angstroms resolution (2015) (0)
Poised-state Dot1L bound to the H2B-Ubiquitinated nucleosome (2019) (0)
Semi-synthesis of ubiquitinated histone H2B with a native or non-hydrolyzable linkage (2019) (0)
Role of the SWIRM Domain in Regulating the HAT Module of the SAGA Complex (2022) (0)
SAGA DUB module Ubp8(C146A)/Sgf11/Sus1/Sgf73 bound to monoubiquitin (2018) (0)
APO FORM OF ESCHERICHIA COLI REGULATORY PROTEIN ARAC (1997) (0)
Structural and mechanistic insights into the SAGA coactivator complex (361.1) (2014) (0)
Crystal Structure of pp32 (2007) (0)
THE CHEMISTRY AND STRUCTURE OF SIRTUINS The Evolving View of Sirtuin Chemistry : From ADP-Ribosylation to Deacylation (2016) (0)
ESCHERCHIA COLI GENE REGULATORY PROTEIN ARAC COMPLEXED WITH D-FUCOSE (1997) (0)
INHIBITED FRAGMENT OF ETS-1 AND PAIRED DOMAIN OF PAX5 BOUND TO DNA (2002) (0)
Structure of the SAGA Ubp8/Sgf11/Sus1/Sgf73 DUB module bound to ubiquitin aldehyde (2010) (0)
Structure of the SAGA Ubp8(S144N)/Sgf11/Sus1/Sgf73 DUB module (2010) (0)
Erratum: A conserved catalytic residue in the ubiquitin-conjugating enzyme family (EMBO Journal (2004) 23, (4876) DOI: 10.1038/sj.emboj.7600513) (2007) (0)
Histone H2B ubiquitination in transcription regulation (2021) (0)
Human Gcn5 bound to butyryl-CoA (2016) (0)
CRYSTAL STRUCTURE OF THE C-TERMINAL WD40 DOMAIN OF TUP1 (2000) (0)
The structure of Sir2Af2 bound to a myristoylated histone peptide (2014) (0)
The Interplay of Phosphorylation and Ubiquitylation in the Regulation of PTEN (2015) (0)
Extracellular Nicotinamide Phosphoribosyltransferase (NAMPT) Shapes the CLL Microenvironment Promoting Macrophage M2 Polarization Via a Non-Enzymatic Mechanism (2014) (0)
The Structural basis of sirtuin substrate specificity (2006) (0)
Sir2-deacetylated peptide (from enzymatic turnover in crystal) (2006) (0)
Sir2-p53 peptide-nicotinamide (2005) (0)
Proteins : histones and chromatin Editorial overview (2011) (0)
Abstract IA004: Novel inhibitors of histone H2B deubiquitinating enzymes (2022) (0)
Structure of C. elegans OTUB1 bound to human UBC13 (2012) (0)
FACT and Ubp 10 collaborate to modulate H 2 B deubiquitination and 2 nucleosome dynamics 3 4 (0)
RAP80, ubiquitin and SUMO in the DNA damage response (2017) (0)
Sir2Af2-NAD-ADPribose-nicotinamide (2005) (0)
Sir2 H116Y mutant-p53 peptide-NAD (2006) (0)
maltose binding-a1 homeodomain protein chimera, crystal form II (2002) (0)
Crystal structure of Sir2Tm in complex with Acetyl p53 peptide and DADMe-NAD+ (2008) (0)
The structure of a ceOTUB1 ubiquitin aldehyde UBC13~Ub complex (2012) (0)
DNA recognition anterior to posterior Structure of HoxA 9 and Pbx 1 bound to DNA : Hox hexapeptide and (2003) (0)
Structure of the SAGA Ubp8(S144N)/Sgf11(1-72, Delta-ZnF)/Sus1/Sgf73 DUB module (2012) (0)
OTUB1 non-catalytically regulates the stability of the E2 ubiquitin conjugating enzyme UBE2E1 (2018) (0)
ESCHERICHIA COLI REGULATORY PROTEIN ARAC COMPLEXED WITH L-ARABINOSE (1997) (0)
Mechanism of histone H2B monoubiquitination by Bre1 (2023) (0)
Crystal Structure of the Rap1 C-terminus (2008) (0)
Mms2/Ubc13~Ubiquitin (2006) (0)
Measuring DNA mechanics on the genome scale (2020) (0)
Quantitative Trait Loci for Refractoriness ofAnopheles gambiae to Plasmodium cynomolgi B (1997) (0)
Sir2 H116A-deacetylated p53 peptide-3'-o-acetyl ADP ribose (2006) (0)
Pax5(1-149)+Ets-1(331-440)+DNA (2002) (0)
Characterization of OTUB1 activation and inhibition by different E2 enzymes (2019) (0)

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