Cyrus Chothia

Q: What Schools Are Affiliated With Cyrus Chothia

Cyrus Chothia is affiliated with the following schools: Birkbeck, University of London, University College London, Durham University, Stanford University, University of Cambridge

Cyrus Chothia's AcademicInfluence.com Rankings

Cyrus Chothia

Biology

#715

World Rank

#1248

Historical Rank

Biochemistry

#389

World Rank

#463

Historical Rank

biology Degrees

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Biology

Why Is Cyrus Chothia Influential?

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According to Wikipedia, Cyrus Homi Chothia was an English biochemist who was an emeritus scientist at the Medical Research Council Laboratory of Molecular Biology at the University of Cambridge and emeritus fellow of Wolfson College, Cambridge.

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Cyrus Chothia's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

SCOP: a structural classification of proteins database for the investigation of sequences and structures. (1995) (6550)
The relation between the divergence of sequence and structure in proteins. (1986) (2322)
The atomic structure of protein-protein recognition sites. (1999) (1924)
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs (2002) (1543)
Canonical structures for the hypervariable regions of immunoglobulins. (1987) (1282)
Assignment of homology to genome sequences using a library of hidden Markov models that represent all proteins of known structure. (2001) (1207)
Structural patterns in globular proteins (1976) (1166)
The nature of the accessible and buried surfaces in proteins. (1976) (1118)
Conformations of immunoglobulin hypervariable regions (1989) (1112)
Data growth and its impact on the SCOP database: new developments (2007) (985)
SCOP database in 2004: refinements integrate structure and sequence family data (2004) (970)
Principles of protein–protein recognition (1975) (964)
One thousand families for the molecular biologist (1992) (889)
SCOP: a structural classification of proteins database (1998) (859)
Interior and surface of monomeric proteins. (1987) (849)
The structure of protein-protein recognition sites. (1990) (771)
Structural invariants in protein folding (1975) (770)
Hydrophobic bonding and accessible surface area in proteins (1974) (761)
Structural mechanisms for domain movements in proteins. (1994) (712)
Haemoglobin: the structural changes related to ligand binding and its allosteric mechanism. (1979) (705)
How different amino acid sequences determine similar protein structures: the structure and evolutionary dynamics of the globins. (1980) (687)
Standard conformations for the canonical structures of immunoglobulins. (1997) (658)
Surface, subunit interfaces and interior of oligomeric proteins. (1988) (601)
The outline structure of the T‐cell alpha beta receptor. (1988) (600)
Sequence comparisons using multiple sequences detect three times as many remote homologues as pairwise methods. (1998) (587)
Principles that determine the structure of proteins. (1984) (571)
Assessing sequence comparison methods with reliable structurally identified distant evolutionary relationships. (1998) (534)
Helix to helix packing in proteins. (1981) (531)
Evolution of the Protein Repertoire (2003) (519)
SCOP database in 2002: refinements accommodate structural genomics (2002) (509)
Volume changes on protein folding. (1994) (475)
The packing density in proteins: standard radii and volumes. (1999) (474)
Determinants of a protein fold. Unique features of the globin amino acid sequences. (1987) (469)
Many of the immunoglobulin superfamily domains in cell adhesion molecules and surface receptors belong to a new structural set which is close to that containing variable domains. (1994) (450)
Conformation of twisted β-pleated sheets in proteins (1973) (417)
SUPERFAMILY—sophisticated comparative genomics, data mining, visualization and phylogeny (2008) (404)
Structural repertoire of the human VH segments. (1992) (403)
Crystal structure of the complex of porcine trypsin with soybean trypsin inhibitor (Kunitz) at 2.6-A resolution. (1974) (383)
Domain association in immunoglobulin molecules. The packing of variable domains. (1985) (369)
Structure, function and evolution of multidomain proteins. (2004) (367)
The molecular structure of cell adhesion molecules. (1997) (355)
The accessible surface area and stability of oligomeric proteins (1987) (331)
Conformations of the third hypervariable region in the VH domain of immunoglobulins. (1998) (327)
3D Complex: A Structural Classification of Protein Complexes (2006) (319)
The classification and origins of protein folding patterns. (1990) (294)
Structure of proteins: packing of alpha-helices and pleated sheets. (1977) (287)
SUPERFAMILY: HMMs representing all proteins of known structure. SCOP sequence searches, alignments and genome assignments (2002) (282)
Evolution of proteins formed by beta-sheets. II. The core of the immunoglobulin domains. (1982) (265)
The SUPERFAMILY database in 2004: additions and improvements (2004) (259)
SCOP: a Structural Classification of Proteins database (1999) (254)
β-Trefoil fold: Patterns of structure and sequence in the Kunitz inhibitors interleukins-1β and 1α and fibroblast growth factors (1992) (253)
Proteins. One thousand families for the molecular biologist. (1992) (240)
The SUPERFAMILY database in 2007: families and functions (2006) (237)
Intermediate sequences increase the detection of homology between sequences. (1997) (234)
Framework residue 71 is a major determinant of the position and conformation of the second hypervariable region in the VH domains of immunoglobulins. (1990) (228)
The structure of a PKD domain from polycystin‐1: implications for polycystic kidney disease (1999) (225)
Principles determining the structure of beta-sheet barrels in proteins. I. A theoretical analysis. (1994) (221)
Packing at the protein-water interface. (1996) (216)
Molecular structure of a new family of ribonucleases (1982) (216)
Protein Family Expansions and Biological Complexity (2006) (215)
SCOP2 prototype: a new approach to protein structure mining (2014) (202)
The predicted structure of immunoglobulin D1.3 and its comparison with the crystal structure (1986) (192)
Volume changes in protein evolution. (1994) (188)
Structural determinants in the sequences of immunoglobulin variable domain. (1998) (181)
The structural repertoire of the human V kappa domain. (1995) (174)
Structural assignments to the Mycoplasma genitalium proteins show extensive gene duplications and domain rearrangements. (1998) (171)
Population statistics of protein structures: lessons from structural classifications. (1997) (171)
The generation of new protein functions by the combination of domains. (2007) (171)
SUPERFAMILY 1.75 including a domain-centric gene ontology method (2010) (169)
Transmission of conformational change in insulin (1983) (164)
Comparative analysis of the polycystic kidney disease 1 (PKD1) gene reveals an integral membrane glycoprotein with multiple evolutionary conserved domains. (1997) (161)
Domain closure in mitochondrial aspartate aminotransferase. (1992) (155)
Mechanisms of domain closure in proteins. (1984) (149)
Structural principles of α/β barrel proteins: The packing of the interior of the sheet (1989) (146)
The geometry of domain combination in proteins. (2002) (145)
Serpin tertiary structure transformation. (1991) (144)
Elbow motion in the immunoglobulins involves a molecular ball-and-socket joint (1988) (141)
Principles determining the structure of beta-sheet barrels in proteins. II. The observed structures. (1994) (141)
SCOP: a Structural Classification of Proteins database (2000) (140)
Outline structure of the human L1 cell adhesion molecule and the sites where mutations cause neurological disorders. (1996) (138)
Determination of protein function, evolution and interactions by structural genomics. (2001) (136)
Analysis of protein loop closure. Two types of hinges produce one motion in lactate dehydrogenase. (1991) (136)
Cadherin superfamily proteins in Caenorhabditis elegans and Drosophila melanogaster. (2001) (133)
Domain closure in lactoferrin. Two hinges produce a see-saw motion between alternative close-packed interfaces. (1993) (132)
Advances in structural genomics. (1999) (132)
Evolution of proteins formed by beta-sheets. I. Plastocyanin and azurin. (1982) (123)
Orthogonal packing of beta-pleated sheets in proteins. (1982) (123)
Role of hydrophobicity in the binding of coenzymes. Appendix. Translational and rotational contribution to the free energy of dissociation. (1978) (121)
Alignment of the amino acid sequences of distantly related proteins using variable gap penalties. (1986) (117)
Domain closure in adenylate kinase. Joints on either side of two helices close like neighboring fingers. (1993) (117)
The evolution and structural anatomy of the small molecule metabolic pathways in Escherichia coli. (2001) (116)
Genomic and structural aspects of protein evolution. (2009) (110)
The immunoglobulin superfamily in Drosophila melanogaster and Caenorhabditis elegans and the evolution of complexity (2003) (110)
Understanding protein structure: using scop for fold interpretation. (1996) (110)
Packing of α-Helices onto β-Pleated sheets and the anatomy of αβ proteins☆ (1980) (103)
Immunoglobulin superfamily proteins in Caenorhabditis elegans. (2000) (99)
Conservation of folding and stability within a protein family: the tyrosine corner as an evolutionary cul-de-sac. (2000) (99)
Stability and specificity of protein-protein interactions: the case of the trypsin-trypsin inhibitor complexes. (1976) (98)
Protein folds in the all-beta and all-alpha classes. (1997) (97)
The response of protein structures to amino-acid sequence changes (1986) (95)
The evolution of protein structures. (1987) (89)
beta-Trefoil fold. Patterns of structure and sequence in the Kunitz inhibitors interleukins-1 beta and 1 alpha and fibroblast growth factors. (1992) (89)
Relative orientation of close-packed beta-pleated sheets in proteins. (1981) (88)
Gene duplications in H. influenzae (1995) (86)
Structural determinants of the conformations of medium‐sized loops in proteins (1989) (73)
Interaction of Acetylcholine with Different Cholinergic Nerve Receptors (1970) (72)
Divergence of interdomain geometry in two-domain proteins. (2006) (70)
Antibody structure, prediction and redesign. (1997) (69)
Domains in proteins: definitions, location, and structural principles. (1985) (69)
Members of the immunoglobulin superfamily in bacteria (1996) (67)
New folds for all-β proteins (1993) (65)
Small-molecule metabolism: an enzyme mosaic. (2001) (63)
Helix movements in proteins (1985) (62)
Genome3D: a UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains (2012) (61)
How far can sequences diverge? (1997) (59)
Evolution of oligomeric state through geometric coupling of protein interfaces (2012) (59)
Helix movements and the reconstruction of the haem pocket during the evolution of the cytochrome c family. (1985) (57)
Role of subunit interfaces in the allosteric mechanism of hemoglobin. (1976) (56)
Canonical structures for the hypervariable regions of T cell αβ receptors 1 1 Edited by J. M. Thornton (2000) (55)
Structure and stability of an immunoglobulin superfamily domain from twitchin, a muscle protein of the nematode Caenorhabditis elegans. (1996) (52)
Structural conservation of hypervariable regions in immunoglobulins evolution (1994) (52)
The 14th barrel rolls out (1988) (52)
Protein architecture: New superfamilies (1992) (51)
Fast assignment of protein structures to sequences using the Intermediate Sequence Library PDB-ISL (2000) (50)
Sequence conservation in families whose members have little or no sequence similarity: the four-helical cytokines and cytochromes. (2002) (49)
Currents in Computational Molecular Biology (2000) (47)
RSDB: representative protein sequence databases have high information content (2000) (47)
Coiling of β-pleated sheets (1983) (46)
Conformation of twisted beta-pleated sheets in proteins. (1973) (46)
Genome3D: exploiting structure to help users understand their sequences (2014) (45)
VH gene segments in the mouse and human genomes. (2004) (43)
Conformations of Acetylcholine (1968) (43)
SCOP, Structural Classification of Proteins database: applications to evaluation of the effectiveness of sequence alignment methods and statistics of protein structural data. (1998) (41)
Solvent accessibility, protein surfaces, and protein folding. (1980) (41)
Ubiquitin--molecular mechanisms for recognition of different structures. (2010) (40)
Structure of proteins: Packing of a-helices and pleated sheets (2000) (37)
The linked conservation of structure and function in a family of high diversity: the monomeric cupredoxins. (2004) (36)
Structural principles of alpha/beta barrel proteins: the packing of the interior of the sheet. (1989) (35)
On the conformations of hallucinogenic molecules and their correlation. (1969) (35)
Molecular structures of hallucinogenic substances: lysergic acid diethylamide, psilocybin, and 2,4,5-trimethoxyamphetamine. (1973) (34)
Protein evolution. How far can sequences diverge? (1997) (34)
Haemoglobin: The surface buried between the α1β1 and α2β2 dimers in the deoxy and oxy structures (1985) (31)
The conformation of cholinergic molecules at nicotinic nerve receptors. (1970) (31)
Fibronectin type III domains in yeast detected by a hidden Markov model (1996) (29)
The selection of acceptable protein mutations (2007) (28)
Conformation of Cholinergic Molecules relevant to Acetylcholinesterase (1969) (27)
Comparison of the small molecule metabolic enzymes of Escherichia coli and Saccharomyces cerevisiae. (2002) (26)
Conformation of acetylcholine at muscarinic nerve receptors: crystal and molecular structure of 2-trimethylammoniummethyl-5-methyl furan iodide (5-methylfurmethide iodide). (1976) (26)
Outline structures for the extracellular domains of the fibroblast growth factor receptors (1995) (22)
Canonical structures for the hypervariable regions of T cell alphabeta receptors. (2000) (20)
Biological Sciences: Absolute Configuration of Cholinergic Molecules; the Crystal Structure of (+)-trans-2-Acetoxy Cyclopropyl Trimethylammonium Iodide (1970) (19)
Protein families in the metazoan genome. (1994) (18)
Investigating Protein Structure and Evolution with SCOP2 (2015) (17)
Proteins in Motion (1999) (17)
The structural homology of amicyanin from Thiobacillus versutus to plant plastocyanins. (1991) (17)
Polyhedra for helical proteins (1989) (17)
The crystal and molecular structure and absolute configuration of l-(+)-(S)-acetyl-β-methylcholine iodide (1978) (16)
Packing of alpha-helices onto beta-pleated sheets and the anatomy of alpha/beta proteins. (1980) (15)
Antigen recognition. (1991) (15)
Two conformations of the cholinergic agonist acetyl-α-methylcholine: a new conformation of cholinergic molecules (1969) (13)
The structure of the potent muscarinic agonist L-(+)-acetyl-β-methylcholine iodide (1969) (12)
Selecting buried residues (1989) (12)
Sequence search algorithm assessment and testing toolkit (SAT) (2000) (12)
Optimal Hidden Markov Models for All Sequences of Known Structure (2000) (11)
Asymmetry in protein structures. (1991) (11)
Acetylcholinesterase: the structure of crystals of a globular form from electric eel. (1975) (11)
Population statistics of protein structures (1997) (10)
SCOP database in 2002 (2002) (10)
Geometric Invariant Core for the CL and CH1 Domains of Immunoglobulin Molecules (2000) (9)
Structure Activity Relationships of some Muscarinic Agonists: a Reply to Shefter and Triggle (1970) (8)
Exegesis: a procedure to improve gene predictions and its use to find immunoglobulin superfamily proteins in the human and mouse genomes. (2003) (8)
Perspectives: signal transduction. Proteins in motion. (1999) (7)
The crystal and molecular structure of 1,1-dimethyl-4-phenylpiperazinium iodide (1978) (6)
New folds for all-beta proteins. (1993) (6)
Coiling of beta-pleated sheets. (1983) (6)
Understanding protein structure (1996) (5)
Protein crystallography: Fifty years of pepsin crystals (1984) (5)
Protein structure: the 14th barrel rolls out. (1988) (4)
Immunoglobulin Fold: Structures of Proteins in the Immunoglobulin Superfamily (2001) (3)
Changes in Protein Evolution Appendix : A method to weight protein sequences to correct for unequal representation (1999) (3)
The crystal and molecular structure and absolute configuration of (+)-(1S,2S)-trans-acetoxycyclopropyltrimethylammonium iodide (1978) (2)
Protein structure. Selecting buried residues. (1989) (2)
Absolute configuration of cholinergic molecules; the crystal structure of (plus)-trans-2-aceoxy cyclopropyl trimethylammonium iodide. (1970) (2)
Haemoglobin: the surface buried between the alpha 1 beta 1 and alpha 2 beta 2 dimers in the deoxy and oxy structures. (1985) (1)
The crystal and molecular structure of dl‐lactoylcholine iodide (1977) (1)
Packing at the protein–water interface (x-ray crystal structureyprotein surfaceyVoronoi polyhedraysolvent structure) (1996) (1)
The conformations of cholinergic agonists. (1970) (1)
Modelling of related proteins (1986) (1)
Fifty years of pepsin crystals. (1984) (1)
Genome sequences and protein structures (abstract) (1999) (0)
Foreword to the First English Edition (2016) (0)
PDB_ISL: an intermediate sequence library for protein structure assignment (2000) (0)
Looking at the bigger picture (2004) (0)
Proposal SAMPLE 1 : Improved Scoring Schemes for Profile-HMMs applied to Protein Analysis (0)
Deoxy- and Liganded-Hemoglobin: The Differences in Structure and Their Relation to Cooperativity in Ligand Binding (1982) (0)
Molecular Models (1971) (0)
Crystallographic methods for determining the confirmation of cholinergic molecules (T) (1970) (0)
The Evolution of Protein Repertoires (2000) (0)
Conformations of loops in immunoglobulins and other proteins (1990) (0)
Genome sequences and protein structures. (2000) (0)

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