Dennis Anthony Carson

Dennis Anthony Carson's AcademicInfluence.com Rankings

Philosophy

#3658

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#5870

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#1308

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#2025

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philosophy Degrees

Dennis Anthony Carson

Biology

#4613

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#6856

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Molecular Biology

#366

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#373

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Genetics

#386

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#449

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biology Degrees

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Philosophy
Biology

Dennis Anthony Carson's Degrees

PhD Molecular Biology Stanford University
Doctorate Medicine Stanford University

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Dennis Anthony Carson's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers (1994) (1966)
Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene Immunization (1996) (1135)
Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants (1997) (979)
Apoptosis and disease (1993) (736)
Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7 (2003) (592)
Effect of neuropeptides on production of inflammatory cytokines by human monocytes (1988) (577)
Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses. (1994) (572)
B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes (1988) (530)
Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization. (1996) (529)
Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis. (1989) (516)
Gene vaccination with naked plasmid DNA: mechanism of CTL priming (1996) (509)
Lasting remissions in hairy-cell leukemia induced by a single infusion of 2-chlorodeoxyadenosine. (1990) (500)
Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells. (1989) (457)
Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1. (1991) (456)
Substance P activation of rheumatoid synoviocytes: neural pathway in pathogenesis of arthritis. (1987) (447)
Activation of the Wnt signaling pathway in chronic lymphocytic leukemia. (2004) (427)
Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. (2004) (395)
Effect of neuropeptides on production of inflammatory cytokines by human monocytes. (1989) (389)
Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes. (1985) (387)
Inhibition of experimental asthma by indoleamine 2,3-dioxygenase. (2004) (369)
Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: possible role of nucleoside kinase(s). (1977) (355)
IL-6 production by human articular chondrocytes. Modulation of its synthesis by cytokines, growth factors, and hormones in vitro. (1990) (352)
Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells (2011) (348)
Expression and function of wingless and frizzled homologs in rheumatoid arthritis. (2000) (329)
DNA strand breaks, NAD metabolism, and programmed cell death. (1986) (312)
Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a (2008) (312)
Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria. (2000) (295)
The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity (2016) (295)
Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck. (1994) (259)
Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia. (1989) (254)
Fibroblast-Like Synoviocytes of Mesenchymal Origin Express Functional B Cell-Activating Factor of the TNF Family in Response to Proinflammatory Cytokines1 (2005) (224)
Autoantibodies in chronic lymphocytic leukemia and related systemic autoimmune diseases. (1993) (222)
In vitro effects of Epstein-Barr virus on peripheral blood mononuclear cells from patients with rheumatoid arthritis and normal subjects (1978) (215)
Specific toxicity of 2-chlorodeoxyadenosine toward resting and proliferating human lymphocytes (1983) (213)
Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivo. (1980) (209)
Bacterial peptidoglycans but not CpG oligodeoxynucleotides activate synovial fibroblasts by toll-like receptor signaling. (2003) (206)
Blockade of Wnt-5A/frizzled 5 signaling inhibits rheumatoid synoviocyte activation. (2001) (205)
Activation of anti-hepatitis C virus responses via Toll-like receptor 7. (2006) (203)
Susceptibility to rheumatoid arthritis maps to a T-cell epitope shared by the HLA-Dw4 DR beta-1 chain and the Epstein-Barr virus glycoprotein gp110. (1989) (193)
Systemic immunological effects of cytokine genes injected into skeletal muscle. (1993) (190)
Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer. (2017) (189)
2-Chlorodeoxyadenosine: An Effective New Agent for the Treatment of Chronic Lymphocytic Leukemia (1988) (184)
Roles of B cells in rheumatoid arthritis (2003) (183)
Transcriptome Sequencing Reveals Potential Mechanism of Cryptic 3’ Splice Site Selection in SF3B1-mutated Cancers (2015) (181)
Relationship of deoxycytidine kinase and cytoplasmic 5'-nucleotidase to the chemotherapeutic efficacy of 2-chlorodeoxyadenosine. (1993) (181)
Positive selection in autoimmunity: Abnormal immune responses to a bacterial dnaJ antigenic determinant in patients with early rheumatoid arthritis (1995) (179)
Transforming growth factor beta and noncytopathic mechanisms of immunodeficiency in human immunodeficiency virus infection. (1990) (179)
Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapy (1988) (177)
2-Chlorodeoxyadenosine treatment of low-grade lymphomas. (1992) (176)
Effect of adenosine deaminase inhibition upon human lymphocyte blastogenesis. (1976) (175)
Cancer progression and p53 (1995) (174)
Nucleotide Requirements for the in Vitro Activation of the Apoptosis Protein-activating Factor-1-mediated Caspase Pathway* (2000) (172)
The antimicrobial activity of liposomal lauric acids against Propionibacterium acnes. (2009) (171)
Biochemical basis for the enhanced toxicity of deoxyribonucleosides toward malignant human T cell lines. (1979) (169)
Rheumatoid factor and immune networks. (1987) (162)
Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine. (1992) (158)
Differential sensitivity of human leukemic T cell lines and B cell lines to growth inhibition by deoxyadenosine. (1978) (156)
Ovarian cancer stem cells express ROR1, which can be targeted for anti–cancer-stem-cell therapy (2014) (156)
Antileukemic and immunosuppressive activity of 2-chloro-2'-deoxyadenosine. (1984) (150)
A conserved human germline V kappa gene directly encodes rheumatoid factor light chains (1986) (144)
Prodigiosin inhibits Wnt/β-catenin signaling and exerts anticancer activity in breast cancer cells (2016) (143)
Evidence for somatic selection of natural autoantibodies (1992) (143)
Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas (2002) (142)
Substituted isoquinolines and quinazolines as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha. (1999) (137)
Transforming growth factor-beta and cellular immune responses in synovial fluids. (1990) (136)
New roles for rheumatoid factor. (1991) (135)
Selective killing of human malignant cell lines deficient in methylthioadenosine phosphorylase, a purine metabolic enzyme. (1981) (134)
Induction of an apoptotic program in cell-free extracts by 2-chloro-2'-deoxyadenosine 5'-triphosphate and cytochrome c. (1998) (130)
Potent toxicity of 2-chlorodeoxyadenosine toward human monocytes in vitro and in vivo. A novel approach to immunosuppressive therapy. (1990) (130)
The potential importance of soluble deoxynucleotidase activity in mediating deoxyadenosine toxicity in human lymphoblasts. (1981) (129)
Radioimmunoassay of IgG and IgM rheumatoid factors reacting with human IgG. (1977) (129)
Immunochemical analysis of the cross-reacting idiotypes of mouse myeloma proteins with anti-dextran activity and normal anti-dextran antibody. (1973) (129)
Increased frequency of rheumatoid factor precursor B lymphocytes after immunization of normal adults with tetanus toxoid. (1983) (127)
Failure of dideoxynucleosides to inhibit human immunodeficiency virus replication in cultured human macrophages (1987) (127)
Activation of resting T lymphocytes by anti-CD3 (T3) antibodies in the absence of monocytes. (1985) (126)
A 16/6 idiotype-positive anti-DNA antibody is encoded by a conserved VH gene with no somatic mutation. (1988) (125)
Ca2+/Mg(2+)-dependent endonuclease from human spleen: purification, properties, and role in apoptosis. (1993) (124)
2-Chlorodeoxyadenosine Treatment of Refractory Chronic Lymphocytic Leukemia. (1991) (123)
Oligonucleotide Adjuvants for T Helper 1 (Th1)–specific Vaccination (1997) (118)
Modulation of disease activity in murine systemic lupus erythematosus by cytokine gene delivery (1995) (117)
Metabolism and anti-human immunodeficiency virus-1 activity of 2-halo-2',3'-dideoxyadenosine derivatives. (1988) (115)
Effects of mutational loss of adenosine kinase and deoxycytidine kinase on deoxyATP accumulation and deoxyadenosine toxicity in cultured CEM human T-lymphoblastoid cells. (1982) (114)
Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia (2010) (113)
2-Chlorodeoxyadenosine: an active agent in the treatment of cutaneous T-cell lymphoma. (1992) (113)
Genomic cloning of methylthioadenosine phosphorylase: a purine metabolic enzyme deficient in multiple different cancers. (1996) (113)
HIV induces lymphocyte apoptosis by a p53‐initiated, mitochondrial‐mediated mechanism (2001) (111)
Characterization of human poly(ADP-ribose) polymerase with autoantibodies. (1988) (111)
Indanocine, a microtubule-binding indanone and a selective inducer of apoptosis in multidrug-resistant cancer cells. (2000) (110)
Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand (2007) (106)
Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven response (1992) (105)
A common idiotope on human rheumatoid factors identified by a hybridoma antibody. (1983) (105)
Adenosine kinase initiates the major route of ribavirin activation in a cultured human cell line. (1978) (104)
Regulation of fibronectin and metalloproteinase expression by Wnt signaling in rheumatoid arthritis synoviocytes. (2002) (103)
Regulation of Epstein‐Barr virus infection by recombinant interferons. Selected sensitivity to interferon‐γ (1985) (102)
Molecular basis of an autoantibody-associated restriction fragment length polymorphism that confers susceptibility to autoimmune diseases. (1991) (102)
Antibodies to Epstein-Barr virus-determined antigens in normal subjects and in patients with seropositive rheumatoid arthritis. (1979) (101)
Synthesis and Immunological Characterization of Toll-Like Receptor 7 Agonistic Conjugates (2009) (99)
Pre-clinical Specificity and Safety of UC-961, a First-In-Class Monoclonal Antibody Targeting ROR1. (2015) (99)
Specific toxicity of 2-chlorodeoxyadenosine toward resting and proliferating human lymphocytes. (1983) (99)
Expression of a cross-reactive idiotype on rheumatoid factor in patients with Sjogren's syndrome. (1986) (98)
Homozygous deletions of methylthioadenosine phosphorylase (MTAP) are more frequent than p16INK4A (CDKN2) homozygous deletions in primary non-small cell lung cancers (NSCLC) (1998) (98)
Abnormal regulation of methylthioadenosine and polyamine metabolism in methylthioadenosine phosphorylase-deficient human leukemic cell lines. (1980) (98)
Incidence of three cross-reactive idiotypes on human rheumatoid factor paraproteins. (1988) (98)
Human Endothelial Cells Produce IL‐6 (1989) (98)
2-Chlorodeoxyadenosine (2-CdA): A Potent Chemotherapeutic and Immunosuppressive Nucleoside. (1991) (96)
Enhancement of the infectivity of SARS-CoV in BALB/c mice by IMP dehydrogenase inhibitors, including ribavirin (2006) (96)
Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7 (2009) (95)
Dependence of adenine production upon polyamine synthesis in cultured human lymphoblasts. (1981) (94)
Isolation and characterization of a light chain variable region gene for human rheumatoid factors (1987) (91)
High-frequency expression of a conserved kappa light-chain variable-region gene in chronic lymphocytic leukemia. (1987) (91)
Bacterial lipopolysaccharide copurifies with plasmid DNA: implications for animal models and human gene therapy. (1995) (90)
The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8 (2008) (90)
Ethacrynic Acid Exhibits Selective Toxicity to Chronic Lymphocytic Leukemia Cells by Inhibition of the Wnt/β-Catenin Pathway (2009) (90)
Basis for defective responses of rheumatoid arthritis synovial fluid lymphocytes to anti-CD3 (T3) antibodies. (1986) (86)
Necessity of Oligonucleotide Aggregation for Toll-like Receptor 9 Activation* (2004) (86)
Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody (2019) (86)
Phytohemagglutinin binds to the 20‐kDa molecule of the T3 complex (1985) (85)
The WNT receptor FZD7 is required for maintenance of the pluripotent state in human embryonic stem cells (2014) (85)
Immunostimulatory DNA Sequences Influence the Course of Adjuvant Arthritis1 (2002) (85)
Lymphocyte dysfunction after DNA damage by toxic oxygen species. A model of immunodeficiency (1986) (83)
Enhancement of Innate Immunity againstMycobacterium avium Infection by Immunostimulatory DNA Is Mediated by Indoleamine 2,3-Dioxygenase (2001) (83)
Adenosine phosphorylase-mediated nucleoside toxicity. Application towards the detection of mycoplasmal infection in mammalian cell cultures. (1982) (82)
Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands as Influenza Virus Vaccine Adjuvants Induce Rapid, Sustained, and Broadly Protective Responses (2015) (81)
Genetic bias in immune responses to a cassette shared by different microorganisms in patients with rheumatoid arthritis. (1997) (81)
Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of compounds related to pifithrin-alpha. (2005) (81)
Costimulation provided by DNA immunization enhances antitumor immunity. (1997) (81)
Autoantibody production by severe combined immunodeficient mice reconstituted with synovial cells from rheumatoid arthritis patients (1990) (80)
WISP3-dependent regulation of type II collagen and aggrecan production in chondrocytes. (2004) (79)
IgG rheumatoid factor in subacute bacterial endocarditis: relationship to IgM rheumatoid factor and circulating immune complexes. (1978) (79)
Phosphorylation and anti-leishmanial activity of formycin B. (1981) (79)
2-Chlorodeoxyadenosine: an effective new agent for the treatment of chronic lymphocytic leukemia. (1988) (79)
TLR4-dependent activation of dendritic cells by an HMGB1-derived peptide adjuvant (2014) (78)
Absence of methylthioadenosine phosphorylase in human gliomas. (1991) (78)
Expression of three cross-reactive idiotypes on rheumatoid factor autoantibodies from patients with autoimmune diseases and seropositive adults. (1986) (78)
Human immune responses to synthetic peptides from the Epstein-Barr nuclear antigen. (1985) (77)
Idiotypic and subgroup analysis of human monoclonal rheumatoid factors. Implications for structural and genetic basis of autoantibodies in humans. (1988) (77)
Transforming growth factor-beta and suppression of humoral immune responses in HIV infection. (1991) (76)
Genetic basis for the cross-reactive idiotypes on the light chains of human IgM anti-IgG autoantibodies. (1986) (76)
Repression of β-catenin function in malignant cells by nonsteroidal antiinflammatory drugs (2005) (74)
New adenosine kinase inhibitors with oral antiinflammatory activity: synthesis and biological evaluation. (1993) (74)
The role of CD40 ligand and tumor necrosis factor alpha signaling in the transgenic K/BxN mouse model of rheumatoid arthritis. (2000) (72)
Antibodies to the Epstein-Barr virus nuclear antigen and to rheumatoid arthritis nuclear antigen identify the same polypeptide. (1983) (71)
Repression of beta-catenin signaling by PPAR gamma ligands. (2010) (70)
Autoantibodies in infectious mononucleosis have specificity for the glycine-alanine repeating region of the Epstein-Barr virus nuclear antigen (1987) (70)
Possible metabolic basis for the different immunodeficient states associated with genetic deficiencies of adenosine deaminase and purine nucleoside phosphorylase. (1982) (69)
The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis. (2005) (69)
Uniform high frequency expression of autoantibody-associated crossreactive idiotypes in the primary B cell follicles of human fetal spleen (1990) (69)
Function of B cells expressing a human immunoglobulin M rheumatoid factor autoantibody in transgenic mice (1993) (69)
Delineation of a cross-reactive idiotype on human autoantibodies with antibody against a synthetic peptide (1984) (68)
Release of lymphokines after Epstein Barr virus infection in vitro. I. Sources of and kinetics of production of interferons and interleukins in normal humans. (1986) (67)
Human rheumatoid factor production is dependent on CD40 signaling and autoantigen. (1999) (67)
Molecular interactions in human T cell-mediated cytotoxicity to EBV II. Monoclonal antibody OKT3 inhibits a post-killer-target recognition/adhesion step. (1982) (67)
The methylthioadenosine phosphorylase gene is frequently co‐deleted with the p16INK4a gene in acute type adult T‐cell leukemia (1998) (67)
Gene Cloning and Characterization of Pseudomonas putida l-Methionine-α-deamino-γ-mercaptomethane-lyase (1996) (67)
Type I interferon is required to mount an adaptive response to immunostimulatory DNA (2001) (66)
Differences in deoxyadenosine metabolism in human and mouse lymphocytes. (1980) (66)
Identification of Substituted Pyrimido[5,4-b]indoles as Selective Toll-Like Receptor 4 Ligands (2013) (66)
Sequence similarities and cross-idiotypic specificity of L chains among human monoclonal IgM kappa with anti-gamma-globulin activity. (1985) (65)
Programmed cell death and adenine deoxynucleotide metabolism in human lymphocytes. (1988) (65)
Systematic transcriptome analysis reveals tumor-specific isoforms for ovarian cancer diagnosis and therapy (2015) (65)
Inhibition of DNA repair by deoxyadenosine in resting human lymphocytes. (1986) (65)
Intraclonal diversity in the VH genes expressed by CD5- chronic lymphocytic leukemia-producing pathologic IgM rheumatoid factor. (1990) (65)
Activation of the classical pathway of complement by rheumatoid factors. Assessment by radioimmunoassay for C4. (1982) (64)
Characterization of four homologous L chain variable region genes that are related to 6B6.6 idiotype positive human rheumatoid factor L chains. (1989) (63)
Detection of p16 Gene Deletions in Gliomas: A Comparison of Fluorescence in Situ Hybridization (FISH) Versus Quantitative PCR (1997) (62)
Characterization of two immunoglobulin VH genes that are homologous to human rheumatoid factors. (1989) (62)
Induction of an Antigen-specific, CD1-restricted Cytotoxic T Lymphocyte Response In vivo (1998) (62)
Methylthioadenosine phosphorylase cDNA transfection alters sensitivity to depletion of purine and methionine in A549 lung cancer cells. (1996) (61)
Evidence for the presence of receptors for C3 and IgG Fc on human synovial cells. (1980) (61)
Autoantibody-associated cross-reactive idiotypes expressed at high frequency in chronic lymphocytic leukemia relative to B-cell lymphomas of follicular center cell origin. (1988) (61)
Human autoantibodies to poly(adenosine diphosphate-ribose) polymerase. (1987) (59)
Inheritance of immunoglobulin M rheumatoid-factor idiotypes. (1980) (59)
Methylthioadenosine phosphorylase deficiency in human non-small cell lung cancers. (1993) (59)
Distinct patterns of heavy chain variable region subgroup use by human monoclonal autoantibodies of different specificity (1988) (58)
Isolation and characterization of human VkIII germ-line genes. Implications for the molecular basis of human VkIII light chain diversity. (1987) (58)
Characterization of human rheumatoid factors with seven antiidiotypes induced by synthetic hypervariable region peptides (1985) (57)
Anti-hypervariable region antibody induced by a defined peptide: an approach for studying the structural correlates of idiotypes. (1984) (57)
The majority of human monoclonal IgM rheumatoid factors express a "primary structure-dependent" cross-reactive idiotype. (1985) (56)
IgA rheumatoid factor in the sera and saliva of patients with rheumatoid arthritis and Sjögren's syndrome. (1979) (56)
Expression of the p16 and p15 cyclin-dependent kinase inhibitors in lymphocyte activation and neuronal differentiation. (1995) (56)
IMMUNOCHEMICAL ANALYSIS OF THE IDIOTYPES OF MOUSE MYELOMA PROTEINS WITH SPECIFICITY FOR LEVAN OR DEXTRAN (1974) (56)
Age-associated changes in Epstein-Barr virus-induced human lymphocyte autoantibody responses. (1981) (55)
2-Chlorodeoxyadenosine dose escalation in nonhematologic malignancies. (1993) (55)
Human monoclonal rheumatoid factors derived from the polyclonal repertoire of rheumatoid synovial tissue: Incidence of cross‐reactive idiotopes and expression of VH and Vϰ subgroups (1990) (55)
Deficiency of methylthioadenosine phosphorylase in human leukemic cells in vivo. (1982) (55)
Assignment of the gene for methylthioadenosine phosphorylase to human chromosome 9 by mouse-human somatic cell hybridization. (1984) (53)
A methylthioadenosine phosphorylase (MTAP) fusion transcript identifies a new gene on chromosome 9p21 that is frequently deleted in cancer (2000) (53)
Inhibition of IgE antibody formation by plasmid DNA immunization is mediated by both CD4+ and CD8+ T cells. (1997) (53)
The expressed T cell receptor V gene repertoire of rheumatoid arthritis monozygotic twins: Rapid analysis by anchored polymerase chain reaction and enzyme‐linked immunosorbent assay (1993) (52)
Release of lymphokines after infection with Epstein Barr virus in vitro. II. A monocyte-dependent inhibitor of interleukin 1 downregulates the production of interleukin 2 and interferon-gamma in rheumatoid arthritis. (1986) (52)
Metabolism of C4 and factor B in rheumatoid arthritis. Relation to rheumatoid factor. (1980) (52)
Irreversible Electroporation Combined with Checkpoint Blockade and TLR7 Stimulation Induces Antitumor Immunity in a Murine Pancreatic Cancer Model (2019) (52)
Studies of HIV infection and the development of Epstein-Barr virus-related B cell lymphomas following transfer of human lymphocytes to mice with severe combined immunodeficiency. (1989) (51)
Induction of antibodies to a kappa V region by gene immunization. (1993) (51)
Antibody to the rheumatoid arthritis nuclear antigen. Its relationship to in vivo Epstein-Barr virus infection. (1980) (51)
Peripheral deletion of rheumatoid factor B cells after abortive activation by IgG. (1997) (50)
CD5-positive B-cell malignancies frequently express cross-reactive idiotypes associated with IgM autoantibodies. (1990) (49)
Structural characterization of human monoclonal cold agglutinins: Evidence for a distinct primary sequence‐defined VH4 idiotype (1990) (48)
The glycine-alanine repeating region is the major epitope of the Epstein-Barr nuclear antigen-1 (EBNA-1). (1987) (48)
Identification of human tumour suppressor genes by monochromosome transfer: rapid growth-arrest response mapped to 9p21 is mediated solely by the cyclin-D-dependent kinase inhibitor gene, CDKN2A (p16INK4A). (1996) (45)
The role of the T3 molecular complex in antigen recognition and subsequent activation events. (1984) (45)
Human immunoglobulin (IgG) induced deletion of IgM rheumatoid factor B cells in transgenic mice (1995) (44)
T lymphocyte-mediated cytotoxicity against autologous EBV-genome-bearing B cells. (1981) (44)
2-Chlorodeoxyadenosine chemotherapy triggers programmed cell death in normal and malignant lymphocytes. (1991) (44)
Transfer of human chronic lymphocytic leukemia to mice with severe combined immune deficiency. (1992) (43)
An infectious origin of extraskeletal calcification. (1998) (43)
Immunoglobulin V Gene Expression in CD5 B‐Cell Malignancies a (1992) (42)
Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7. (2008) (42)
Repression of beta-catenin function in malignant cells by nonsteroidal antiinflammatory drugs. (2005) (42)
Targeting the Wnt/beta-catenin pathway with the antifungal agent ciclopirox olamine in a murine myeloma model. (2011) (41)
Biochemical genetic analysis of indanocine resistance in human leukemia. (2001) (41)
Human endothelial cells produce IL-6. Lack of responses to exogenous IL-6. (1989) (40)
Importance of Toll-Like Receptor 9 in Host Defense against M1T1 Group A Streptococcus Infections (2011) (39)
Cellular requirements for pokeweed mitogen-induced autoantibody production rheumatoid arthritis. (1980) (39)
Inhibition of HER-kinase activation prevents ERK-mediated degradation of PPARgamma. (2004) (39)
Cloning and sequence determination of a human rheumatoid factor light-chain gene. (1986) (38)
Competitive RT-PCR ELISA: a rapid, sensitive and non-radioactive method to quantitate cytokine mRNA. (1994) (38)
The incidence of a new human cross-reactive idiotype linked to subgroup VHIII heavy chains. (1990) (38)
Characterization of an epibody. An antiidiotype that reacts with both the idiotype of rheumatoid factors (RF) and the antigen recognized by RF (1985) (38)
Microtiter format gene quantification by covalent capture of competitive PCR products: application to HIV-1 detection. (1993) (38)
Two different rheumatoid factor-producing cell populations distinguished by the mouse erythrocyte receptor and responsiveness to polyclonal B cell activators. (1983) (37)
Possible deletion of a developmentally regulated heavy-chain variable region gene in autoimmune diseases. (1990) (37)
Enhancement of the Immunostimulatory Activity of a TLR7 Ligand by Conjugation to Polysaccharides. (2015) (37)
NOTCH1 Signaling Promotes Human T-Cell Acute Lymphoblastic Leukemia Initiating Cell Regeneration in Supportive Niches (2012) (36)
Targeting Wnt pathway in lymphoma and myeloma cells (2009) (36)
Autoantigen inhibits apoptosis of a human B cell leukemia that produces pathogenic rheumatoid factor. (1993) (36)
Biochemical genetic analysis of the role of methylthioadenosine phosphorylase in a murine lymphoid cell line. (1983) (35)
Genetic factors in the etiology and pathogenesis of autoimmunity 1 (1992) (35)
From human autoantibodies to the fetal antibody repertoire to B cell malignancy: it's a small world after all. (1990) (35)
Selection of oligonucleotide aptamers with enhanced uptake and activation of human leukemia B cells. (2003) (35)
Genetic control of T cell receptor BJ gene expression in peripheral lymphocytes of normal and rheumatoid arthritis monozygotic twins. (1996) (34)
Molecular characterization of a supratypic cross-reactive idiotype associated with IgM autoantibodies. (1991) (34)
Relative reactivities of rheumatoid factors in serum and cells. Evidence for a selective deficiency in serum rheumatoid factor. (1978) (34)
Rational design, synthesis and structure-activity relationships of antitumor (E)-2-benzylidene-1-tetralones and (E)-2-benzylidene-1-indanones. (2000) (34)
Substituted xanthines, pteridinediones, and related compounds as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha. (1996) (34)
Pyrimidine nucleotide and nucleic acid synthesis in human monocytes and macrophages. (1991) (33)
Synthesis and characterization of PEGylated toll like receptor 7 ligands. (2011) (33)
5-Aza-2'-deoxycytidine leads to down-regulation of aberrant p16INK4A RNA transcripts and restores the functional retinoblastoma protein pathway in hepatocellular carcinoma cell lines. (2000) (32)
Sequence analyses of three immunoglobulin G anti-virus antibodies reveal their utilization of autoantibody-related immunoglobulin Vh genes, but not V lambda genes. (1992) (32)
Characterization of an adenosine 5'-triphosphate- and deoxyadenosine 5'-triphosphate-activated nucleotidase from human malignant lymphocytes. (1982) (32)
A systematic approach to defining the germline gene counterparts of a mutated autoantibody from a patient with rheumatoid arthritis. (1992) (32)
9-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)guanine: a metabolically stable cytotoxic analogue of 2'-deoxyguanosine. (1986) (32)
The internal image of IgG in cross-reactive anti-idiotypic antibodies against human rheumatoid factors. (1983) (32)
Idiotypic and genetic studies of human rheumatoid factors. (1987) (32)
Synthesis of 2',3'-dideoxynucleosides by enzymatic trans-glycosylation. (1988) (32)
Deoxyadenosine-resistant human T lymphoblasts with elevated 5'-nucleotidase activity. (1991) (31)
Differential regulation of polyamine synthesis and transmethylation reactions in methylthioadenosine phosphorylase deficient mammalian cells. (1985) (31)
Genetic and epigenetic profiling of CLL disease progression reveals limited somatic evolution and suggests a relationship to memory-cell development (2015) (31)
Lymphocyte dysfunction caused by deficiencies in purine metabolism. (1981) (31)
Population and family studies of three disease-related polymorphic genes in systemic lupus erythematosus. (1995) (30)
Metabolism to methionine and growth stimulation by 5'-methylthioadenosine and 5'-methylthioinosine in mammalian cells. (1983) (30)
Membrane antigen on Epstein--Barr virus-infected human B cells recognized by a monoclonal antibody. (1982) (30)
Autoantibody-encoding kappa L chain genes frequently rearranged in lambda L chain-expressing chronic lymphocytic leukemia. (1991) (30)
Biased estimates of clonal evolution and subclonal heterogeneity can arise from PCR duplicates in deep sequencing experiments (2014) (29)
Light chain heterogeneity of 19S and 7S anti-gamma-globulins in rheumatoid arthritis and subacute bacterial endocarditis. (1978) (29)
The specificity of anti-DNA antibodies in systemic lupus erythematosus. (1991) (28)
Greatly enhanced inhibition of human immunodeficiency virus type 1 replication in CEM and HT4-6C cells by 3'-deoxythymidine diphosphate dimyristoylglycerol, a lipid prodrug of 3'-deoxythymidine (1992) (28)
Selective induction of autoantibody secretion in human bone marrow by Epstein Barr virus. (1982) (28)
The human immunoglobulin V(H) gene repertoire is genetically controlled and unaltered by chronic autoimmune stimulation. (1996) (28)
Amide derivatives of ethacrynic acid: synthesis and evaluation as antagonists of Wnt/beta-catenin signaling and CLL cell survival. (2009) (28)
Structural and idiotypic characterization of the L chains of human IgM autoantibodies with different specificities. (1989) (27)
A highly informative probe for two polymorphic Vh gene regions that contain one or more autoantibody-associated Vh genes. (1989) (27)
Quantitative immunoassay of adenosine deaminase in combined immunodeficiency disease. (1977) (26)
Human autoantibodies to poly(adenosine diphosphate-ribose) polymerase recognize cross-reactive epitopes associated with the catalytic site of the enzyme. (1989) (26)
Role of IL-1 receptor-associated kinase-M (IRAK-M) in priming of immune and inflammatory responses by nitrogen bisphosphonates (2011) (26)
Synthetic peptides corresponding to third hypervariable region of human monoclonal IgM rheumatoid factor heavy chains define an immunodominant idiotype (1985) (26)
Presence of circulating immune complexes in Reiter's syndrome and ankylosing spondylitis (1981) (26)
Increased in vivo efficacy of lenalidomide by addition of piroctone olamine. (2011) (25)
Defining the genetic origins of three rheumatoid synovium-derived IgG rheumatoid factors. (1994) (25)
Modulation of human rheumatoid factor-specific lymphocyte responses with a cross-reactive anti-idiotype bearing the internal image of antigen. (1984) (25)
Synthesis and immunostimulatory activity of 8-substituted amino 9-benzyladenines as potent Toll-like receptor 7 agonists. (2006) (24)
Phosphatidylazidothymidine. Mechanism of antiretroviral action in CEM cells. (1991) (24)
Quantitative immunoassay of human deoxycytidine kinase in malignant cells. (1992) (24)
Optimization of primer design for the detection of variable genomic lesions in cancer (2007) (24)
In vivo efficacy of griseofulvin against multiple myeloma. (2011) (24)
Idiotypic cross-reactivity of immunoglobulins expressed in Waldenström's macroglobulinemia, chronic lymphocytic leukemia, and mantle zone lymphocytes of secondary B-cell follicles. (1991) (24)
Increased in vivo efficacy of lenalidomide and thalidomide by addition of ethacrynic acid. (2011) (23)
Generation and molecular analyses of two rheumatoid synovial fluid-derived IgG rheumatoid factors. (1993) (23)
Spiperone enhances intracellular calcium level and inhibits the Wnt signaling pathway (2009) (23)
Discovery of substituted 4-aminoquinazolines as selective Toll-like receptor 4 ligands. (2014) (23)
Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands Work Additively via MyD88 To Induce Protective Antiviral Immunity in Mice (2017) (23)
Human kappa light chain subgroup analysis with synthetic peptide-induced antisera. (1986) (23)
Different populations of rheumatoid factor idiotypes induced by two polyclonal B cell activators, pokeweed mitogen and Epstein--Barr virus. (1981) (22)
Influencing the Wnt signaling pathway in multiple myeloma. (2011) (22)
Lack of mutation at p16INK4A gene but expression of aberrant p16INK4A RNA transcripts in human ovarian carcinoma. (2000) (22)
In vivo efficacy of the diuretic agent ethacrynic acid against multiple myeloma. (2012) (22)
Cutting Edge: Nitrogen Bisphosphonate-Induced Inflammation Is Dependent upon Mast Cells and IL-1 (2012) (22)
Thymidine-phosphorothioate oligonucleotides induce activation and apoptosis of CLL cells independently of CpG motifs or BCL-2 gene interference (2006) (22)
Dependence of cell survival on DNA repair in human mononuclear phagocytes. (1991) (22)
Oral 2-chlorodeoxyadenosine in psoriatic (1995) (22)
Opposing roles of RNA receptors TLR3 and RIG-I in the inflammatory response to double-stranded RNA in a Kaposi's sarcoma cell line. (2007) (22)
Additive melanoma suppression with intralesional phospholipid-conjugated TLR7 agonists and systemic IL-2 (2011) (22)
Pyridine nucleotide cycling and poly(ADP-ribose) synthesis in resting human lymphocytes. (1987) (21)
Biochemical genetic analysis of 2',3'-dideoxyadenosine metabolism in human T lymphocytes. (1988) (21)
Treatment of Autoimmune Inflammation by a TLR7 Ligand Regulating the Innate Immune System (2012) (21)
Induction of Tolerogenic Dendritic Cells by a PEGylated TLR7 Ligand for Treatment of Type 1 Diabetes (2015) (21)
Inhibition of Wnt signaling and cancer stem cells (2011) (21)
Apoptosis Induced by Molecular Targeting Therapy in Hematological Malignancies (2003) (21)
IgM rheumatoid factor autoantibody and immunoglobulin-producing precursor cells in the bone marrow of humans. (1985) (21)
Delivery of Immunotherapeutic Nanoparticles to Tumors via Enzyme‐Directed Assembly (2019) (21)
In vivo efficacy of a phosphodiester TLR-9 aptamer and its beneficial effect in a pulmonary anthrax infection model. (2008) (21)
Divergent T cell receptor gamma repertoires in rheumatoid arthritis monozygotic twins. (1993) (21)
Generation and characterization of two monoclonal self-associating IgG rheumatoid factors from a rheumatoid synovium. (1992) (21)
Salinomycin exerts anti‐colorectal cancer activity by targeting the β‐catenin/T‐cell factor complex (2019) (20)
Structural similarities in the kappa light chains of human rheumatoid factor paraproteins and serum immunoglobulins bearing a cross-reactive idiotype. (1985) (20)
Tumor promoter TPA activates Wnt/β-catenin signaling in a casein kinase 1-dependent manner (2018) (20)
A Novel Approach for Determining Cancer Genomic Breakpoints in the Presence of Normal DNA (2007) (20)
Regulation of the mature human T cell receptor gamma repertoire by biased V-J gene rearrangement. (1993) (20)
Synthesis and biological evaluation of 2',4'- and 3',4'-bridged nucleoside analogues. (2011) (19)
Thoracic duct drainage in rheumatoid arthritis. (1984) (19)
2-Chlorodeoxyadenosine: hairy cell leukemia takes a surprising turn. (1993) (19)
Structure-Activity Relationship Studies of Pyrimido[5,4-b]indoles as Selective Toll-Like Receptor 4 Ligands. (2017) (19)
The immune response to Epstein-Barr nuclear antigen: conformational and structural features of antibody binding to synthetic peptides. (1984) (19)
Unconventional T-cell activation by IL-15 in rheumatoid arthritis (1997) (18)
Metabolic Basis for Immune Dysfunction in Adenosine Deaminase Deficiency a (1985) (18)
Identification of Biologically Active Pyrimido[5,4-b]indoles That Prolong NF-κB Activation without Intrinsic Activity. (2017) (17)
Lymphocyte mitogenesis induced by monoclonal antibodies to the T3 complex. Differential modulation by human IgG. (1984) (17)
Amino acid sequence of a light chain variable region of a human rheumatoid factor of the Wa idiotypic group, in part predicted by its reactivity with antipeptide antibodies. (1986) (17)
Novel Synthetic Toll-Like Receptor 4/MD2 Ligands Attenuate Sterile Inflammation (2014) (17)
Effects of recombinant human interferons on rheumatoid arthritis B lymphocytes activated by Epstein-Barr virus. (1987) (17)
Thymidine as a chemotherapeutic agent: pharmacologic, cytokinetic, and biochemical studies in a patient with T-cell acute lymphocytic leukemia. (1980) (17)
Synergistic inhibition of polyamine synthesis and growth by difluoromethylornithine plus methylthioadenosine in methylthioadenosine phosphorylase-deficient murine lymphoma cells. (1987) (17)
Physiology and pathology of rheumatoid factors (2005) (17)
Idiotypic and molecular characterization of human rheumatoid factors. (1990) (16)
Control of immune responses by gene immunization. (1998) (16)
Stimulation of HIV replication in mononuclear phagocytes by leukemia inhibitory factor. (1994) (16)
Solid-phase selection of human T lymphocyte subpopulations using monoclonal antibodies. (1981) (16)
Fractionation of human lymphocyte subpopulations on immunoglobulin coated Petri dishes. (1981) (16)
Frequencies of Epstein-Barr virus-inducible IgM anti-IgG B lymphocytes in normal children and children with juvenile rheumatoid arthritis. (1982) (16)
Innate Immune Protection against Infectious Diseases by Pulmonary Administration of a Phospholipid-Conjugated TLR7 Ligand (2013) (16)
Molecular interactions in human T-cell-mediated cytotoxicity to Epstein-Barr virus. I. Blocking of effector cell function by monoclonal antibody OKT3. (1982) (15)
Cell-penetrating peptide CGKRK mediates efficient and widespread targeting of bladder mucosa following focal injury. (2017) (15)
Characterization of an adenosine deaminase-deficient human histiocytic lymphoma cell line (DHL-9) and selection of mutants deficient in adenosir kinase and deoxycytidine kinase. (1983) (15)
Tolerance to a self peptide from the third hypervariable region of the E βs chain. Implications for molecular mimicry models of autoimmune disease (1991) (15)
Lysis of autologous Epstein-Barr virus-infected B cells by cytotoxic T lymphocytes of rheumatoid arthritis patients. (1982) (14)
A sensitive array-based assay for identifying multiple TMPRSS2:ERG fusion gene variants (2008) (14)
Human T cell hybridomas specific for Epstein Barr virus-infected B lymphocytes. (1983) (14)
Independent regulation of ornithine decarboxylase and S-adenosylmethionine decarboxylase in methylthioadenosine phosphorylase-deficient malignant murine lymphoblasts. (1985) (14)
Quinolinium salt as a potent inhibitor of lymphocyte apoptosis. (2005) (14)
Synthesis and release of deoxycytidine by human B and T lymphoblasts. (1986) (14)
Induction of oligoclonal CD8 T cell responses against pulmonary metastatic cancer by a phospholipid-conjugated TLR7 agonist (2018) (14)
Synthesis of 2-Chloro-2’-5’-dideoxy-5’-difluoromethylphosphinyladenosine: A Nonhydrolyzable Isosteric, Isopolar Analog of 2-Chlorodeoxyadenosine Monophosphate (1996) (14)
Dissociation of expression of two rheumatoid factor cross-reactive kappa L chain idiotopes in rheumatoid arthritis. (1990) (14)
Analysis of high‐throughput screening assays using cluster enrichment (2012) (14)
A Novel Synthetic Dual Agonistic Liposomal TLR4/7 Adjuvant Promotes Broad Immune Responses in an Influenza Vaccine With Minimal Reactogenicity (2020) (13)
5'-Methylthioadenosine is the major source of adenine in human cells. (1984) (13)
Hairy-cell leukaemia as a model for drug development. (2003) (13)
Facile synthesis of 9-substituted 9-deazapurines as potential purine nucleoside phosphorylase inhibitors. (2002) (13)
Purification and characterization of recombinant human 5'-methylthioadenosine phosphorylase: definite identification of coding cDNA. (1996) (13)
Poly(ADP-ribose) polymerase inhibits DNA synthesis initiation in the absence of NAD. (1989) (13)
Genetic analysis of human B cell hybridomas expressing a cross-reactive idiotype. (1987) (13)
Gene cloning and characterization of Pseudomonas putida L-methionine-alpha-deamino-gamma-mercaptomethane-lyase. (1996) (13)
Cross-reacting idiotypes on cryoprecipitating rheumatoid factor (2005) (12)
Generation and Application of a Reporter Cell Line for the Quantitative Screen of Extracellular Vesicle Release (2021) (12)
Whole Transcriptome Sequencing Enables Discovery and Analysis of Viruses in Archived Primary Central Nervous System Lymphomas (2013) (12)
Correlation between anti-RANA and anti-EBNA titers in normal subjects with and without HLA-DRw4. (1980) (12)
Differential production of deoxyadenosine by human T and B lymphoblasts. (1983) (12)
Oral administration of PEGylated TLR7 ligand ameliorates alcohol-associated liver disease via the induction of IL-22 (2020) (11)
Selective lymphocyte deficiency in seronegative rheumatoid arthritis. (1981) (11)
Resistance to multiple adenine nucleoside and methionine analogues in mutant murine lymphoma cells with enlarged S-adenosylmethionine pools. (1986) (11)
Modulation of ceramide-activated protein phosphatase 2A activity by low molecular weight aromatic compounds. (1998) (11)
Cirmtuzumab Vedotin (UC-961ADC3), An Anti-ROR1-Monomethyl Auristatin E Antibody-Drug Conjugate, Is a Potential Treatment For ROR1-Positive Leukemia and Solid Tumors (2013) (11)
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two (2016) (11)
Origin and age-associated changes in the expression of a physiologic autoantibody. (1985) (11)
Influence of the rheumatoid arthritis-associated shared epitope on T-cell receptor repertoire formation. (1996) (11)
Apoptosis in rheumatic disease. (1995) (10)
Formation of DNA strand breaks by D-penicillamine and bucillamine in human lymphocytes. (1993) (10)
Inhibition of keratinocyte proliferation by phospholipid-conjugates of a TLR7 ligand in a Myc-induced hyperplastic actinic keratosis model in the absence of systemic side effects. (2013) (10)
Idiotypes in biology and medicine. (1989) (10)
Ontogeny of synonymous T cell populations with specificity for a self MHC epitope mimicked by a bacterial homologoue: an antigen‐specific T cell analysis in a non‐transgenic system (1999) (10)
Oral 2-chlorodeoxyadenosine in psoriatic arthritis. A preliminary report. (1995) (10)
Isolation of an IgG monoclonal anti-dnaJ antibody from an immunoglobulin combinatorial library from a patient with rheumatoid arthritis. (1999) (10)
A window-of-opportunity biomarker study of etodolac in resectable breast cancer (2015) (9)
Conjugation of a Small Molecule TLR7 Agonist to Silica Nanoshells Enhances Adjuvant Activity. (2019) (9)
The common occurrence of internal image type anti-idiotypic antibodies in rabbits immunized with monoclonal and polyclonal human IgM rheumatoid factors. (1986) (9)
New heterocycles of 2,3‐diaryl‐substituted maleic hydrazides (2011) (9)
Deoxynucleoside overproduction in deoxyadenosine-resistant, adenosine deaminase-deficient human histiocytic lymphoma cells. (1984) (9)
Profound toxicity of deoxyadenosine and 2-chlorodeoxyadenosine toward human monocytes in vitro and in vivo. (1989) (9)
Sequential metabolism of 5'-isobutylthioadenosine by methylthioadenosine phosphorylase and purine-nucleoside phosphorylase in viable human cells. (1982) (9)
Selection and characterization of a murine lymphoid cell line partially deficient in S-adenosylhomocysteine hydrolase. (1983) (9)
Transcriptome Sequencing of Tumor Subpopulations Reveals a Spectrum of Therapeutic Options for Squamous Cell Lung Cancer (2013) (9)
Molecular basis for the cross-reactive idiotypes on human anti-IgG autoantibodies (rheumatoid factors). (1987) (9)
Regulation of rheumatoid factor synthesis. (1989) (9)
3-amino thioacridone inhibits DNA synthesis and induce DNA damage in T-cell acute lymphoblastic leukemia (T-ALL) in a p16-dependent manner. (2005) (9)
IgG rheumatoid factors isolated by the surface-displaying phage library technique (1997) (9)
Cold agglutinins: specificity, idiotypy and structural analysis. (1990) (9)
Changes in the expression of two Epstein‐Barr virus‐associated antigens, EBNA and RANA, during the cell cycle of transformed human B lymphoblasts (1980) (9)
Restricted Expression of the Orphan Tyrosine Kinase Receptor ROR1 in Chronic Lymphocytic Leukemia. (2004) (9)
A FZD7-specific Antibody–Drug Conjugate Induces Ovarian Tumor Regression in Preclinical Models (2021) (8)
Molecular cloning of the human methylthioadenosine phosphorylase processed pseudogene and localization to 3q28. (1997) (8)
Identification of Compounds That Prolong Type I Interferon Signaling as Potential Vaccine Adjuvants (2018) (8)
Repression of β -catenin signaling by PPAR γ ligands (2010) (8)
Wnt signaling in rheumatoid synoviocyte activation (2002) (8)
Preclinical Development Of ROR1 Peptide Based Vaccine With Activity Against Chronic Lymphocytic Leukemia In ROR1 Transgenic Mice (2013) (8)
Lymphoblastoid B cell lines produce an interleukin-1-like activity that can be serologically distinct from macrophage interleukin-1. (1986) (8)
Rheumatoid factor B cell tolerance via autonomous Fas/FasL-independent apoptosis. (1999) (8)
Recent Advances and Perspectives in Small-molecule TLR Ligands and Their Modulators. (2018) (8)
Immunostimulatory TLR7 Agonist‐Nanoparticles Together with Checkpoint Blockade for Effective Cancer Immunotherapy (2020) (8)
Mast Cell-Mediated Inhibition of Abdominal Neutrophil Inflammation by a PEGylated TLR7 Ligand (2011) (8)
Identification of immunostimulatory DNA-induced genes by suppression subtractive hybridization. (2001) (8)
Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L 1210 leukemia in vivo ( adenosine deaminase / chemotherapy ) (8)
Structural and functional characteristics of the CD3 (T3) molecular complex on human thymocytes. (1987) (8)
Fighting arthritis with a senescence gene (1999) (8)
Discovery of a Novel Microtubule Targeting Agent as an Adjuvant for Cancer Immunotherapy (2018) (8)
Comparative studies to determine the efficiency of 6 methylpurine deoxyriboside to detect cell culture mycoplasmas (1986) (7)
Methylthioadenosine (MeSAdo) phosphorylase deficiency in malignancy. (1988) (7)
Modulation of diphthamide synthesis by 5'-deoxy-5'-methylthioadenosine in murine lymphoma cells. (1986) (7)
Occurrence of two germline‐related rheumatoid factor idiotypes in rheumatoid arthritis and in non‐rheumatoid seropositive individuals (1990) (7)
Modulation of adenine nucleoside excretion and incorporation in adenosine deaminase deficient human lymphoma cells. (1984) (7)
Gold nanoparticles co-immobilized with small molecule toll-like receptor 7 ligand and α-mannose as adjuvants. (2019) (7)
Differential cyst(e)ine requirements in human T and B lymphoblastoid cell lines. (1982) (7)
Discordant expression of 2 Epstein-Barr virus-associated antigens, EBNA and RANA, in man-rodent somatic cell hybrids. (1981) (7)
Biochemical basis for deoxyadenosine and 2-chlorodeoxyadenosine toxicity to resting human lymphocytes. (1986) (7)
Activity of 2-chloro-2'-deoxyadenosine in chronic lymphocytic leukemia, hairy cell leukemia, and autoimmune hemolytic anemia. (1989) (7)
Immunodeficiency secondary to adenosine deaminase deficiency and purine nucleoside phosphorylation deficiency. (1990) (6)
Hairy cell leukemia: new understanding of biology and treatment. (1993) (6)
Putrescine dependent growth of mycoplasma infected mammalian cells (1983) (6)
Expression of a germline human kappa chain-associated cross-reactive idiotype after in vitro and in vivo infection with Epstein-Barr virus. (1987) (6)
Inhibition of Chronic Myelogenous Leukemia Stem Cells with Novel Wnt Antagonists. (2006) (5)
Effects of monoclonal antibodies against lymphocyte surface antigens on interleukin 2 excretion by Epstein-Barr virus-specific human T-cell hybridomas. (1984) (5)
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Structure-Activity Relationship Studies to Identify Affinity Probes in Bis-aryl Sulfonamides that Prolong Immune Stimuli. (2019) (5)
Increased aldehyde dehydrogenase activity in high-risk chronic lymphocytic leukemia (2013) (5)
Formation of peripheral immunoreceptor repertoire for antigens: potential relationship to the pathogenesis of rheumatoid arthritis. (1998) (5)
Selective activation of FZD7 promotes mesendodermal differentiation of human pluripotent stem cells (2020) (5)
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Characterization of a crossreactive idiotype in Sjögren's syndrome. (1986) (5)
Genotyping by PCR-ELISA of a complex polymorphic region that contains one to four copies of six highly homologous human VH3 genes. (1997) (5)
Rheumatoid factors in human autoimmune disease: their origin, development and function. (1986) (5)
Dinucleotide repeat polymorphism adjacent to CDKN2. (1994) (5)
5'-deoxy-5'-methylthioadenosine phosphorylase deficiency in leukemia: genetics and biochemical aspects. (1986) (4)
Antibodies to Epstein-Barr virus associated antigens in Pima Indians with and without rheumatoid arthritis (2004) (4)
The role of the T3 molecular complex on human T lymphocyte-mediated cytotoxicity. (1985) (4)
Biochemical basis for lymphocyte dysfunction in adenosine deaminase and purine nucleoside phosphorylase deficiencies. (1984) (4)
Effect of levamisole on pokeweed mitogen stimulation of immunoglobulin production in vitro. (1981) (4)
Release of lymphokines following Epstein-Barr virus infection in vitro of blood lymphocytes from patients with autoimmune diseases. (1986) (4)
Optimizing PCR Assays for DNA-Based Cancer Diagnostics (2010) (4)
5'-Methylthioadenosine phosphorylase deficiency in malignant cells: recessive expression of the defective phenotype in intraspecies (mouse X mouse) hybrids. (1984) (4)
Guanosine analog in the pyrido[2,3-d]pyrimidine ring system As a potential Toll-like receptor agonist (2006) (4)
The value of epitope mapping in autoimmune diseases. (1994) (4)
Immunoreactive adenosine deaminase (ADA) in cultured fibroblasts from patients with combined immunodeficiency disease. (1977) (4)
Idiotypes and the structural diversity of human rheumatoid factors (2005) (4)
Analyses of human rheumatoid factors with anti-idiotypes induced by synthetic peptides. (1987) (4)
Deoxyribonucleoside toxicity in adenosine deaminase and purine nucleoside phosphorylase deficiency: implications for the development of new immunosuppressive agents. (1978) (4)
Detection of p16 gene deletions in gliomas: Fluorescence in situ hybridization (FISH) versus quantitative PCR (1997) (4)
Age-related restriction of the light chain heterogeneity of anti-IgG antibodies induced by Epstein-Barr virus stimulation of human lymphocytes in vitro. (1981) (4)
9-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)guanine: A Metabolically Stable Cytotoxic Analogue of 2′-Deoxyguanosine. (1987) (4)
Selective killing of Leishmania infected mouse macrophages by 6-methylpurine 2'-deoxyriboside. (1981) (4)
Interleukins and Interferons during EBV Infection (1987) (3)
Substituted Xanthines, Pteridinediones, and Related Compounds as Potential Antiinflammatory Agents. Synthesis and Biological Evaluation of Inhibitors of Tumor Necrosis Factor α. (1996) (3)
Pathogenic mechanisms in deficiencies of adenosine deaminase and purine nucleoside phosphorylase (1979) (3)
Genetic studies of four highly homologous rheumatoid factor-associated Vk genes in rheumatoid arthritis patients and normal individuals. (1991) (3)
Adenosine deaminase activity in recipients of bone marrow from immunodeficient mice homozygous for the wasted mutation. (1987) (3)
The diversity and idiotypic patterns of human rheumatoid factors in disease. (1988) (3)
Characterization of the Human Autoantibody Response to Poly(ADP-Ribose) Polymerase (1989) (3)
Immunoglobulin Gene Rearrangement and Expression in B-CLL. (1991) (3)
Idiotypic characteristics of rheumatoid factors. (1988) (3)
Possible involvement of human D minigenes in the first complementarity-determining region of kappa light chains. (1985) (3)
Metabolism and toxicity of 9-beta-D-arabinofuranosyladenine in human malignant T cells and B cells in tissue culture. (1979) (3)
Inhibition of Wnt Signaling By Dimethyl Fumarate Results in in Vitro and in Vivo Clearance of Chronic Lymphocytic Leukemia Cells and Has Additive Activity with Ibrutinib (2014) (3)
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Molecular cloning of poly adp ribosepolymerase using human autoantibodies (1987) (3)
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Mitochondria-dependent synthetic small-molecule vaccine adjuvants for influenza virus infection (2021) (3)
Small Molecule Calcium Channel Activator Potentiates Adjuvant Activity (2022) (2)
Highly Specific Inhibitor for Syk Induces Chronic Lymphocytic Leukemia Cell Apoptosis (2011) (2)
Review Roles of B cells in rheumatoid arthritis (2003) (2)
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Cell cycle independent lymphocytotoxicity of 2-chlorodeoxyadenosine. (1984) (2)
Glyco-Nanoadjuvants: Sugar Structures on Carriers of a Small Molecule TLR7 Ligand Affect Their Immunostimulatory Activities (2021) (2)
Inhibition of Casein Kinase 2 Impairs Wnt Signaling and Cell Survival in Chronic Lymphocytic Leukemia (2016) (2)
Agelastatin A (AgA), a Marine Sponge Derived Alkaloid, Inhibits Wnt/Beta-Catenin Signaling and Selectively Induces Apoptosis in Chronic Lymphocytic Leukemia Independently of p53 (2011) (2)
Transforming growth factor-beta (TGF beta) inhibition of Epstein-Barr virus (EBV)- and interleukin-4 (IL-4)-induced immunoglobulin production in human B lymphocytes. (1993) (2)
Inhibition of anti-CD3 (T3) antibody-induced activation of T cells by cyclosporine. (1986) (2)
A Highly Selective Anti-ROR1 Monoclonal Antibody Inhibits Human Acute Myeloid Leukemia CD34+ Cell Survival and Self-Renewal. (2012) (2)
Proteomic Analysis Reveals IRAK4 As a Therapeutic Target in Chronic Lymphocytic Leukemia (2017) (2)
A polymerase chain reaction-based method for isolation of gene-specific sequences from the interferon-α gene cluster (1992) (2)
Absence of Methylthioadenosine Phosphorylase in Human Gliomas 1 (2006) (2)
A Monoclonal Antibody Specifically Targeting CD44 Inhibits B-Cell Chronic Lymphocytic Leukemia Cell Survival In Vitro and In Vivo (2011) (2)
Small Molecule Potentiator of Adjuvant Activity Enhancing Survival to Influenza Viral Challenge (2021) (2)
cDNA sequence of human ribosomal protein L31. (1989) (2)
Selection of mutant murine lymphoid cells partially deficient in S-adenosylhomocysteine hydrolase (1982) (2)
Regulation of S-Adenosylmethionine and Methylthioadenosine Metabolism in Methylthioadenosine Phosphorylase Deficient Malignant Cells (1986) (2)
T Cell Response to Peptides Encompassing a 5 Amino Acid Sequence Shared by the HLA DW4 DR Beta 1 Chain and the Epstein Barr Virus Glycoprotein GP110 (1989) (2)
Synthesis of 2‐Chloro‐2′‐5′‐dideoxy‐5′‐ difluoromethylphosphinyladenosine (XI): A Nonhydrolyzable Isosteric, Isopolar Analogue of 2‐Chlorodeoxyadenosine Monophosphate. (1996) (2)
717 Inhibition of specific IgE antibody formation by naked plasmid DNA immunization (1996) (1)
New Heterocycles of 2,3‐Diaryl‐Substituted Maleic Hydrazides. (2012) (1)
2‐Chlorodeoxyadenosine (Cladribine): Rational Development of a Novel Chemotherapeutic Agent (2006) (1)
Thecommonoccurrence ofinternal imagetypeanti-idiotypic antibodies inrabbits immunized withmonoclonal and polyclonal humanIgMrheumatoid factors (1986) (1)
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Presence of circulation immune complexes in Reiter's syndrome and ankylosing spondylitis. (1981) (1)
Identification of Compounds With Glucocorticoid Sparing Effects on Suppression of Chemokine and Cytokine Production by Rheumatoid Arthritis Fibroblast-Like Synoviocytes (2020) (1)
Structure-activity relationship studies in substituted sulfamoyl benzamidothiazoles that prolong NF-κB activation. (2021) (1)
Molecular genetic analysis of chromosome 9p in methylthioadenosine phosphorylase deficient glioma cell lines. (1991) (1)
Transforming growth factor-β (TGFβ) inhibition of epstein-barr virus (EBV)- and interleukin-4 (IL-4)-induced immunoglobulin production in human B lymphocytes (1993) (1)
Genetic Analysis of Deoxyadenosine Toxicity in Dividing Human Lymphoblasts (1986) (1)
Rheumatoid Factor in Sjögren’s Syndrome (1987) (1)
Selective Clearance of Chronic Lymphocytic Leukemia Cells in Vivo Following Treatment with UC99961, an Anti-ROR1 Monoclonal Antibody (2012) (1)
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Optimizing PCR Assays for DNA Based Cancer Diagnostics (2009) (1)
Pivotal Role of Poly(ADP-Ribose) Polymerase Activation in the Pathogenesis of Immunodeficiency and in the Therapy of Chronic Lymphocytic Leukemia (1989) (1)
Characterization of Epstein-Barr virus-specific T-cell hybridomas derived from infectious mononucleosis. (1985) (1)
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17 PROFOUND TOXICITY OF DEOXYADENOSINE (dAdo) AND 2-CHLORODEOXYADENOSINE (CdA) TOWARD HUMAN MONOCYTES IN VITRO AND IN VIVO (1988) (0)
2-halo-2',3'-dideoxyadenosines: metabolically stable dideoxynucleosides with activity against the human immunodeficiency virus (HIV). (1989) (0)
5′-DEOXY–5′-METHYLTHIOADENOSINE (MTA) PHOSPHORYLASE DEFICIENCY IN LEUKEMIA: GENETICS AND BIOCHEMICAL ASPECTS: 28 (1985) (0)
HUMAN MALIGNANT T CELLS AND B CELLS IN TISSUE CULTURE (1980) (0)
CHECKPOINT INHIBITION WITH SYSTEMIC ANTI‐PROGRAMMED CELL DEATH LIGAND‐1 AND INTRAVESICAL TMX‐101 DECREASE TUMOR BURDEN IN A MOUSE MODEL OF UROTHELIAL CARCINOMA: MP98‐05 (2017) (0)
Autoantigen Dependent on CD 40 Signaling and Human Rheumatoid Factor Production (1999) (0)
An innovative system for 3 D clinical photography in the resource-limited settings (2014) (0)
Response to Proinflammatory Cytokines Cell-Activating Factor of the TNF Family in Mesenchymal Origin Express Functional B Fibroblast-Like Synoviocytes of (2004) (0)
Cancer monitoring with nanoparticles and microfluidics (2008) (0)
Are Rheumatoid Factors Produced During Conventional Immune Responses Beneficial to the Host? (2019) (0)
Association of Autoantigenic Epitope and Catalytic Site on Poly (ADP-Ribose) Polymerase (1989) (0)
affecting the mitochondria lymphocytic leukemia cells by damaging the DNA and by directly Deoxyadenosine analogs induce programmed cell death in chronic (2013) (0)
Tecfidera Modulates Activation of Malignant B-Cells: Correlative Analysis from a Phase 1 Clinical Trial in Patients with Chronic Lymphocytic Leukemia (2018) (0)
A method for selectively methioninentzug for malignant mammalian cells (1994) (0)
647 TLR7 Signaling As Potential Therapeutic Target for Mouse Model of Alcoholic Hepatitis (2015) (0)
Immunoglobulin gene expression in systemic rheumatic diseases. (1991) (0)
Biased estimates of clonal evolution and subclonal heterogeneity can arise from PCR duplicates in deep sequencing experiments (2014) (0)
Author response: Selective activation of FZD7 promotes mesendodermal differentiation of human pluripotent stem cells (2020) (0)
171 UTILIZATION OF 2′-DEOXYNAD FOR ADP-RIBOSE TRANSFER REACTIONS (1988) (0)
The importance of methylthioadenosine phosphorylase deficiency in human malignancy (1982) (0)
Jarvis Edwin Seegmiller, MD, 1920–2006 (2006) (0)
Expression vectors induce antigen-specific immune response and methods for their use. (1997) (0)
Role of Rheumatoid Factor B Cells in Normal and Pathologic Antigen Presentation (1999) (0)
Inhibition Of Wnt Signaling In Chronic Lymphocytic Leukemia Has Synergistic Cytotoxicity With Ibrutinib (2013) (0)
Optimized NSAIDs for Breast Cancer Prevention (2006) (0)
Cloning and sequence determination of a human rheumatoid factor light-chain gene ( human hybridoma / idiotypes / chronic lymphatic leukemia ) (2003) (0)
Gene Vaccinat ion with Naked P lasmid (2003) (0)
Oxidative Stress Response and Cytotoxicity of Electrophilic Compounds in Primary Human Chronic Lymphocytic Leukemia. (2009) (0)
Induction of Anti-RF Antibodies with PGL 1 Peptide 325 (2003) (0)
Intradermal geneimmunization: Thepossible roleofDNA uptake intheinduction ofcellular immunity toviruses (1994) (0)
Possible metabolic basis forthedifferent immunodeficient states associated withgenetic deficiencies ofadenosine deaminase andpurine nucleoside phosphorylase (deoxyadenosine/deoxyguanosine/adenosylhomocysteine/lymphocytes) (1982) (0)
Bacterial Lipopolysaccharide Copurifies with P l a s m i d D N A : Implications for A n i m a l (2008) (0)
Rational Design, Synthesis, and Structure—Activity Relationships of Antitumor (E)-2-Benzylidene-1-tetralones and (E)-2-Benzylidene-1-indanones. (2000) (0)
Epigenetic modulation enhances vaccine efficacy (2008) (0)
Cross-Reactive Idiotypes of Rheumatoid Factors in Arthritis and Related Diseases (2020) (0)
THE NATURE OF AUTOIMMUNE-DISEASE - GENERAL DISCUSSION (1987) (0)
Targeting Of Chronic Lymphocytic Leukemia B Cells With a Humanized Monoclonal Antibody Specific For ROR1 (2013) (0)
Guanosine Analogue in the Pyrido[2,3-d]pyrimidine Ring System as a Potential Toll-Like Receptor Agonist. (2007) (0)
NCI NanoTumor Center at UCSD (2007) (0)
Brief Definitive Report in Vitro Effects of Epstein-barr Virus on Peripheral Blood Mononuclear Cells from Patients with Rheumatoid Arthritis and Normal Subjects* (0)
Dependent upon Mast Cells and IL-1 Bisphosphonate-Induced Inflammation Is Cutting Edge: Nitrogen (2017) (0)
Abstract 2568: Application of novel phospholipid conjugated Toll like receptor 7 ligands for cancer therapy by topical and systemic administration (2014) (0)
173 ADENOSINE DEAMINASE ACTIVITY IN RECIPIENTS OF BONE MARROU FROM IMMUNODEFICIENT MICE HOMOZYGOUS FOR THE WASTED MUTATION (1988) (0)
Increased Activity of Aldehyde Dehydrogenase, a Stem/Progenitor Cell Marker, in Chronic Lymphocytic Leukemia, (2011) (0)
23 Human T-T H ybridomas Specific for Epstein-Barr (1985) (0)
A polymorphic region defined by pCN2 (the 3′ nontranslated region of N-ras) maps to chromosome 9cen-p12 (1991) (0)
Infection and Immunity: Mechanisms of Immunodeficiency in Inborn Errors of Purine Metabolism (1985) (0)
Selective Inhibition of Activated B-Cell Lymphoma Cells by a Novel Small Molecule Inhibitor of NF-κB (2011) (0)
Human T-T Hybridomas Specific for Epstein—Barr Virus (1985) (0)
Comment on Venables letter (1984) (0)
A sensitive array-based assay to identify multiple TMPRSS2:ERG fusion variants in prostate cancer (2008) (0)
Abstract 206: Depletion of ovarian cancer initiating cells by a monoclonal antibody against ROR1 (2014) (0)
polypnea in mice Central histamine contributed to temperature-induced (2015) (0)
Assay of anti-Epstein-Barr virus nuclear antigen antibodies with synthetic polypeptides (1990) (0)
[Rheumatoid factors]. (1982) (0)
MECHANISM OF ADENOSINE TOXICITY TO ADENOSINE KINASE DEFICIENT MAMMALIAN CELLS: 30 (1985) (0)
adenine derivatives as therapeutic agents usable substituted. (1989) (0)
Changes in deoxyadenosine production during human lymphocyte mitogenesis. (1984) (0)
Perspectives NewRoles for Rheumatoid Factor (2013) (0)
Methylthioadenosine Phosphorylase eDNA Transfection Alters Sensitivity to Depletion of Purine and Methionine in A 549 Lung Cancer Cells ' (0)
Isolation of cancer-specific CDKN2A breakpoint fusion sequences in the presence of contaminating normal DNA (2006) (0)
Conjugates of synthetic TLR agonists and their uses (2008) (0)
Transforming growth factor f8andnoncytopathic mechanisms of immunodeficiency inhumanimmunodeficiency virus infection (1990) (0)
Pharmacologic Modulation of STAT1 and Wnt Signaling in Chronic Lymphocytic Leukemia (2015) (0)
Covalent coupling of a novel TLR7 agonist to antigen elicits an effective immune response in a murine melanoma tumor model (2007) (0)
Editorial: Wnt Signaling in Immune Cell Regulation During Microbial Infection and Cancer (2020) (0)
181 CHARACTERIZATION OF POLY(ADP-RIBOSE) POLYMERASE WITH HUMAN AUTOANTIBODIES (1988) (0)
Progress in Clinical Immunology. Volume 4. Edited by Robert S. Schwartz, MD, New York, Grune and Stratton, Inc., 1980. 179 pages. Illustrated. $23.50 (1982) (0)
180 MODULATION OF DIPHTHAMIDE SYNTHESIS BY METHYLTHIOADENOSINE (1988) (0)
Heterogeneity of the toxic mechanisms of methylthioadenosine in methylthioadenosine phosphorylase deficient murine lymphoma cells. (1989) (0)
A cross reactive idiotype on rheumatoid factor is found in Sjogren's syndrome patients in different parts of the world (1989) (0)
Influence the Course of Adjuvant Arthritis Immunostimulatory DNA Sequences (2001) (0)
Substituted adenine derivatives and pharmaceutical compositions containing them and the use of substituted adenine derivatives for the manufacture of medicaments (1989) (0)
In Appreciation of William J. Koopman, MD editor, arthritis and rheumatism, 1985–90 (1990) (0)
[Modulation of immunocompetent cells in the synovial fluid TGF-beta]. (1991) (0)
BIOCHEMICAL BASIS FOR DEOXYADENOSINE AND 2-CHLORODEOXYADENOSINE TOXICITY TO BESTING HDMAN LYMPHOCYTES: 187 (1985) (0)
Differential Expression Profile of the Proteome and Transcriptome in Aggressive and Indolent Chronic Lymphocytic Leukemia. (2005) (0)
Abstract 489: Buoyant targeted microbubble technology provides efficient and superior quality of hematopoietic stem cells isolated from umbilical cord blood (2020) (0)
The Immune Response to Glycine-Rich Sequences of Epstein-Barr Nuclear Antigen-1 (EBNA-1) in Autoimmunity: B and T Cell Epitopes (1989) (0)
Gene immunization for the induction of antigen-specific, non MHC-restricted responses (1998) (0)
And substituted adeninderivat anvaendbara som substanser therapeutic efficacy. (1989) (0)
Tcl-1 Inhibits Nuclear Export of TR3 and Is Highly Expressed in ZAP70-Positive CLL B-Cells. (2004) (0)
The Role of Immunostimulatory DNA Sequences in Arthritis (2002) (0)
Increased level of ribonucleotide reductase in deoxyadenosine resistant adenosine deaminase deficient human histiocytic lymphoma cells. (1986) (0)
Expression of the pl 6 and pl 5 Cyclin-dependent Kinase Inhibitors in Lymphocyte Activation and Neuronal Differentiation 1 (2006) (0)
Molecular Basis of Epibody Reactivity (2018) (0)
19 2-HALO-2′,3′-DIDEOXYADENOSINES: METABOLICALLY STABLE DIDEOXYNUCLEOSIDES WITH ACTIVITY AGAINST THE HUMAN IMMUNODEFICIENCY VIRUS (HIV) (1988) (0)
Action mechanisms and anti-lymphoma properties of Neplanocin A (1987) (0)
Bioluminescent Monitoring of Microenvironmental Effects on Multiple Myeloma Engraftment In a Humanized Mouse Model (2010) (0)
Award Number: W81XWH-04-1-0453 TITLE: Optimized NSAIDs for Breast Cancer Prevention (2007) (0)
Detection of p16 gene deletions in gliomas: Fish vs. quantitative PCR (1997) (0)
Title Pages / Table of Contents (2013) (0)

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