Dennis Anthony Carson
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Philosophy Biology
Dennis Anthony Carson's Degrees
- PhD Molecular Biology Stanford University
- Doctorate Medicine Stanford University
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(Suggest an Edit or Addition)Dennis Anthony Carson's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers (1994) (1966)
- Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene Immunization (1996) (1135)
- Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants (1997) (979)
- Apoptosis and disease (1993) (736)
- Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7 (2003) (592)
- Effect of neuropeptides on production of inflammatory cytokines by human monocytes (1988) (577)
- Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses. (1994) (572)
- B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes (1988) (530)
- Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization. (1996) (529)
- Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis. (1989) (516)
- Gene vaccination with naked plasmid DNA: mechanism of CTL priming (1996) (509)
- Lasting remissions in hairy-cell leukemia induced by a single infusion of 2-chlorodeoxyadenosine. (1990) (500)
- Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells. (1989) (457)
- Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1. (1991) (456)
- Substance P activation of rheumatoid synoviocytes: neural pathway in pathogenesis of arthritis. (1987) (447)
- Activation of the Wnt signaling pathway in chronic lymphocytic leukemia. (2004) (427)
- Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. (2004) (395)
- Effect of neuropeptides on production of inflammatory cytokines by human monocytes. (1989) (389)
- Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes. (1985) (387)
- Inhibition of experimental asthma by indoleamine 2,3-dioxygenase. (2004) (369)
- Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: possible role of nucleoside kinase(s). (1977) (355)
- IL-6 production by human articular chondrocytes. Modulation of its synthesis by cytokines, growth factors, and hormones in vitro. (1990) (352)
- Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells (2011) (348)
- Expression and function of wingless and frizzled homologs in rheumatoid arthritis. (2000) (329)
- DNA strand breaks, NAD metabolism, and programmed cell death. (1986) (312)
- Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a (2008) (312)
- Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria. (2000) (295)
- The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity (2016) (295)
- Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck. (1994) (259)
- Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia. (1989) (254)
- Fibroblast-Like Synoviocytes of Mesenchymal Origin Express Functional B Cell-Activating Factor of the TNF Family in Response to Proinflammatory Cytokines1 (2005) (224)
- Autoantibodies in chronic lymphocytic leukemia and related systemic autoimmune diseases. (1993) (222)
- In vitro effects of Epstein-Barr virus on peripheral blood mononuclear cells from patients with rheumatoid arthritis and normal subjects (1978) (215)
- Specific toxicity of 2-chlorodeoxyadenosine toward resting and proliferating human lymphocytes (1983) (213)
- Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivo. (1980) (209)
- Bacterial peptidoglycans but not CpG oligodeoxynucleotides activate synovial fibroblasts by toll-like receptor signaling. (2003) (206)
- Blockade of Wnt-5A/frizzled 5 signaling inhibits rheumatoid synoviocyte activation. (2001) (205)
- Activation of anti-hepatitis C virus responses via Toll-like receptor 7. (2006) (203)
- Susceptibility to rheumatoid arthritis maps to a T-cell epitope shared by the HLA-Dw4 DR beta-1 chain and the Epstein-Barr virus glycoprotein gp110. (1989) (193)
- Systemic immunological effects of cytokine genes injected into skeletal muscle. (1993) (190)
- Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer. (2017) (189)
- 2-Chlorodeoxyadenosine: An Effective New Agent for the Treatment of Chronic Lymphocytic Leukemia (1988) (184)
- Roles of B cells in rheumatoid arthritis (2003) (183)
- Transcriptome Sequencing Reveals Potential Mechanism of Cryptic 3’ Splice Site Selection in SF3B1-mutated Cancers (2015) (181)
- Relationship of deoxycytidine kinase and cytoplasmic 5'-nucleotidase to the chemotherapeutic efficacy of 2-chlorodeoxyadenosine. (1993) (181)
- Positive selection in autoimmunity: Abnormal immune responses to a bacterial dnaJ antigenic determinant in patients with early rheumatoid arthritis (1995) (179)
- Transforming growth factor beta and noncytopathic mechanisms of immunodeficiency in human immunodeficiency virus infection. (1990) (179)
- Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapy (1988) (177)
- 2-Chlorodeoxyadenosine treatment of low-grade lymphomas. (1992) (176)
- Effect of adenosine deaminase inhibition upon human lymphocyte blastogenesis. (1976) (175)
- Cancer progression and p53 (1995) (174)
- Nucleotide Requirements for the in Vitro Activation of the Apoptosis Protein-activating Factor-1-mediated Caspase Pathway* (2000) (172)
- The antimicrobial activity of liposomal lauric acids against Propionibacterium acnes. (2009) (171)
- Biochemical basis for the enhanced toxicity of deoxyribonucleosides toward malignant human T cell lines. (1979) (169)
- Rheumatoid factor and immune networks. (1987) (162)
- Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine. (1992) (158)
- Differential sensitivity of human leukemic T cell lines and B cell lines to growth inhibition by deoxyadenosine. (1978) (156)
- Ovarian cancer stem cells express ROR1, which can be targeted for anti–cancer-stem-cell therapy (2014) (156)
- Antileukemic and immunosuppressive activity of 2-chloro-2'-deoxyadenosine. (1984) (150)
- A conserved human germline V kappa gene directly encodes rheumatoid factor light chains (1986) (144)
- Prodigiosin inhibits Wnt/β-catenin signaling and exerts anticancer activity in breast cancer cells (2016) (143)
- Evidence for somatic selection of natural autoantibodies (1992) (143)
- Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas (2002) (142)
- Substituted isoquinolines and quinazolines as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha. (1999) (137)
- Transforming growth factor-beta and cellular immune responses in synovial fluids. (1990) (136)
- New roles for rheumatoid factor. (1991) (135)
- Selective killing of human malignant cell lines deficient in methylthioadenosine phosphorylase, a purine metabolic enzyme. (1981) (134)
- Induction of an apoptotic program in cell-free extracts by 2-chloro-2'-deoxyadenosine 5'-triphosphate and cytochrome c. (1998) (130)
- Potent toxicity of 2-chlorodeoxyadenosine toward human monocytes in vitro and in vivo. A novel approach to immunosuppressive therapy. (1990) (130)
- The potential importance of soluble deoxynucleotidase activity in mediating deoxyadenosine toxicity in human lymphoblasts. (1981) (129)
- Radioimmunoassay of IgG and IgM rheumatoid factors reacting with human IgG. (1977) (129)
- Immunochemical analysis of the cross-reacting idiotypes of mouse myeloma proteins with anti-dextran activity and normal anti-dextran antibody. (1973) (129)
- Increased frequency of rheumatoid factor precursor B lymphocytes after immunization of normal adults with tetanus toxoid. (1983) (127)
- Failure of dideoxynucleosides to inhibit human immunodeficiency virus replication in cultured human macrophages (1987) (127)
- Activation of resting T lymphocytes by anti-CD3 (T3) antibodies in the absence of monocytes. (1985) (126)
- A 16/6 idiotype-positive anti-DNA antibody is encoded by a conserved VH gene with no somatic mutation. (1988) (125)
- Ca2+/Mg(2+)-dependent endonuclease from human spleen: purification, properties, and role in apoptosis. (1993) (124)
- 2-Chlorodeoxyadenosine Treatment of Refractory Chronic Lymphocytic Leukemia. (1991) (123)
- Oligonucleotide Adjuvants for T Helper 1 (Th1)–specific Vaccination (1997) (118)
- Modulation of disease activity in murine systemic lupus erythematosus by cytokine gene delivery (1995) (117)
- Metabolism and anti-human immunodeficiency virus-1 activity of 2-halo-2',3'-dideoxyadenosine derivatives. (1988) (115)
- Effects of mutational loss of adenosine kinase and deoxycytidine kinase on deoxyATP accumulation and deoxyadenosine toxicity in cultured CEM human T-lymphoblastoid cells. (1982) (114)
- Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia (2010) (113)
- 2-Chlorodeoxyadenosine: an active agent in the treatment of cutaneous T-cell lymphoma. (1992) (113)
- Genomic cloning of methylthioadenosine phosphorylase: a purine metabolic enzyme deficient in multiple different cancers. (1996) (113)
- HIV induces lymphocyte apoptosis by a p53‐initiated, mitochondrial‐mediated mechanism (2001) (111)
- Characterization of human poly(ADP-ribose) polymerase with autoantibodies. (1988) (111)
- Indanocine, a microtubule-binding indanone and a selective inducer of apoptosis in multidrug-resistant cancer cells. (2000) (110)
- Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand (2007) (106)
- Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven response (1992) (105)
- A common idiotope on human rheumatoid factors identified by a hybridoma antibody. (1983) (105)
- Adenosine kinase initiates the major route of ribavirin activation in a cultured human cell line. (1978) (104)
- Regulation of fibronectin and metalloproteinase expression by Wnt signaling in rheumatoid arthritis synoviocytes. (2002) (103)
- Regulation of Epstein‐Barr virus infection by recombinant interferons. Selected sensitivity to interferon‐γ (1985) (102)
- Molecular basis of an autoantibody-associated restriction fragment length polymorphism that confers susceptibility to autoimmune diseases. (1991) (102)
- Antibodies to Epstein-Barr virus-determined antigens in normal subjects and in patients with seropositive rheumatoid arthritis. (1979) (101)
- Synthesis and Immunological Characterization of Toll-Like Receptor 7 Agonistic Conjugates (2009) (99)
- Pre-clinical Specificity and Safety of UC-961, a First-In-Class Monoclonal Antibody Targeting ROR1. (2015) (99)
- Specific toxicity of 2-chlorodeoxyadenosine toward resting and proliferating human lymphocytes. (1983) (99)
- Expression of a cross-reactive idiotype on rheumatoid factor in patients with Sjogren's syndrome. (1986) (98)
- Homozygous deletions of methylthioadenosine phosphorylase (MTAP) are more frequent than p16INK4A (CDKN2) homozygous deletions in primary non-small cell lung cancers (NSCLC) (1998) (98)
- Abnormal regulation of methylthioadenosine and polyamine metabolism in methylthioadenosine phosphorylase-deficient human leukemic cell lines. (1980) (98)
- Incidence of three cross-reactive idiotypes on human rheumatoid factor paraproteins. (1988) (98)
- Human Endothelial Cells Produce IL‐6 (1989) (98)
- 2-Chlorodeoxyadenosine (2-CdA): A Potent Chemotherapeutic and Immunosuppressive Nucleoside. (1991) (96)
- Enhancement of the infectivity of SARS-CoV in BALB/c mice by IMP dehydrogenase inhibitors, including ribavirin (2006) (96)
- Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7 (2009) (95)
- Dependence of adenine production upon polyamine synthesis in cultured human lymphoblasts. (1981) (94)
- Isolation and characterization of a light chain variable region gene for human rheumatoid factors (1987) (91)
- High-frequency expression of a conserved kappa light-chain variable-region gene in chronic lymphocytic leukemia. (1987) (91)
- Bacterial lipopolysaccharide copurifies with plasmid DNA: implications for animal models and human gene therapy. (1995) (90)
- The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8 (2008) (90)
- Ethacrynic Acid Exhibits Selective Toxicity to Chronic Lymphocytic Leukemia Cells by Inhibition of the Wnt/β-Catenin Pathway (2009) (90)
- Basis for defective responses of rheumatoid arthritis synovial fluid lymphocytes to anti-CD3 (T3) antibodies. (1986) (86)
- Necessity of Oligonucleotide Aggregation for Toll-like Receptor 9 Activation* (2004) (86)
- Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody (2019) (86)
- Phytohemagglutinin binds to the 20‐kDa molecule of the T3 complex (1985) (85)
- The WNT receptor FZD7 is required for maintenance of the pluripotent state in human embryonic stem cells (2014) (85)
- Immunostimulatory DNA Sequences Influence the Course of Adjuvant Arthritis1 (2002) (85)
- Lymphocyte dysfunction after DNA damage by toxic oxygen species. A model of immunodeficiency (1986) (83)
- Enhancement of Innate Immunity againstMycobacterium avium Infection by Immunostimulatory DNA Is Mediated by Indoleamine 2,3-Dioxygenase (2001) (83)
- Adenosine phosphorylase-mediated nucleoside toxicity. Application towards the detection of mycoplasmal infection in mammalian cell cultures. (1982) (82)
- Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands as Influenza Virus Vaccine Adjuvants Induce Rapid, Sustained, and Broadly Protective Responses (2015) (81)
- Genetic bias in immune responses to a cassette shared by different microorganisms in patients with rheumatoid arthritis. (1997) (81)
- Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of compounds related to pifithrin-alpha. (2005) (81)
- Costimulation provided by DNA immunization enhances antitumor immunity. (1997) (81)
- Autoantibody production by severe combined immunodeficient mice reconstituted with synovial cells from rheumatoid arthritis patients (1990) (80)
- WISP3-dependent regulation of type II collagen and aggrecan production in chondrocytes. (2004) (79)
- IgG rheumatoid factor in subacute bacterial endocarditis: relationship to IgM rheumatoid factor and circulating immune complexes. (1978) (79)
- Phosphorylation and anti-leishmanial activity of formycin B. (1981) (79)
- 2-Chlorodeoxyadenosine: an effective new agent for the treatment of chronic lymphocytic leukemia. (1988) (79)
- TLR4-dependent activation of dendritic cells by an HMGB1-derived peptide adjuvant (2014) (78)
- Absence of methylthioadenosine phosphorylase in human gliomas. (1991) (78)
- Expression of three cross-reactive idiotypes on rheumatoid factor autoantibodies from patients with autoimmune diseases and seropositive adults. (1986) (78)
- Human immune responses to synthetic peptides from the Epstein-Barr nuclear antigen. (1985) (77)
- Idiotypic and subgroup analysis of human monoclonal rheumatoid factors. Implications for structural and genetic basis of autoantibodies in humans. (1988) (77)
- Transforming growth factor-beta and suppression of humoral immune responses in HIV infection. (1991) (76)
- Genetic basis for the cross-reactive idiotypes on the light chains of human IgM anti-IgG autoantibodies. (1986) (76)
- Repression of β-catenin function in malignant cells by nonsteroidal antiinflammatory drugs (2005) (74)
- New adenosine kinase inhibitors with oral antiinflammatory activity: synthesis and biological evaluation. (1993) (74)
- The role of CD40 ligand and tumor necrosis factor alpha signaling in the transgenic K/BxN mouse model of rheumatoid arthritis. (2000) (72)
- Antibodies to the Epstein-Barr virus nuclear antigen and to rheumatoid arthritis nuclear antigen identify the same polypeptide. (1983) (71)
- Repression of beta-catenin signaling by PPAR gamma ligands. (2010) (70)
- Autoantibodies in infectious mononucleosis have specificity for the glycine-alanine repeating region of the Epstein-Barr virus nuclear antigen (1987) (70)
- Possible metabolic basis for the different immunodeficient states associated with genetic deficiencies of adenosine deaminase and purine nucleoside phosphorylase. (1982) (69)
- The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis. (2005) (69)
- Uniform high frequency expression of autoantibody-associated crossreactive idiotypes in the primary B cell follicles of human fetal spleen (1990) (69)
- Function of B cells expressing a human immunoglobulin M rheumatoid factor autoantibody in transgenic mice (1993) (69)
- Delineation of a cross-reactive idiotype on human autoantibodies with antibody against a synthetic peptide (1984) (68)
- Release of lymphokines after Epstein Barr virus infection in vitro. I. Sources of and kinetics of production of interferons and interleukins in normal humans. (1986) (67)
- Human rheumatoid factor production is dependent on CD40 signaling and autoantigen. (1999) (67)
- Molecular interactions in human T cell-mediated cytotoxicity to EBV II. Monoclonal antibody OKT3 inhibits a post-killer-target recognition/adhesion step. (1982) (67)
- The methylthioadenosine phosphorylase gene is frequently co‐deleted with the p16INK4a gene in acute type adult T‐cell leukemia (1998) (67)
- Gene Cloning and Characterization of Pseudomonas putida l-Methionine-α-deamino-γ-mercaptomethane-lyase (1996) (67)
- Type I interferon is required to mount an adaptive response to immunostimulatory DNA (2001) (66)
- Differences in deoxyadenosine metabolism in human and mouse lymphocytes. (1980) (66)
- Identification of Substituted Pyrimido[5,4-b]indoles as Selective Toll-Like Receptor 4 Ligands (2013) (66)
- Sequence similarities and cross-idiotypic specificity of L chains among human monoclonal IgM kappa with anti-gamma-globulin activity. (1985) (65)
- Programmed cell death and adenine deoxynucleotide metabolism in human lymphocytes. (1988) (65)
- Systematic transcriptome analysis reveals tumor-specific isoforms for ovarian cancer diagnosis and therapy (2015) (65)
- Inhibition of DNA repair by deoxyadenosine in resting human lymphocytes. (1986) (65)
- Intraclonal diversity in the VH genes expressed by CD5- chronic lymphocytic leukemia-producing pathologic IgM rheumatoid factor. (1990) (65)
- Activation of the classical pathway of complement by rheumatoid factors. Assessment by radioimmunoassay for C4. (1982) (64)
- Characterization of four homologous L chain variable region genes that are related to 6B6.6 idiotype positive human rheumatoid factor L chains. (1989) (63)
- Detection of p16 Gene Deletions in Gliomas: A Comparison of Fluorescence in Situ Hybridization (FISH) Versus Quantitative PCR (1997) (62)
- Characterization of two immunoglobulin VH genes that are homologous to human rheumatoid factors. (1989) (62)
- Induction of an Antigen-specific, CD1-restricted Cytotoxic T Lymphocyte Response In vivo (1998) (62)
- Methylthioadenosine phosphorylase cDNA transfection alters sensitivity to depletion of purine and methionine in A549 lung cancer cells. (1996) (61)
- Evidence for the presence of receptors for C3 and IgG Fc on human synovial cells. (1980) (61)
- Autoantibody-associated cross-reactive idiotypes expressed at high frequency in chronic lymphocytic leukemia relative to B-cell lymphomas of follicular center cell origin. (1988) (61)
- Human autoantibodies to poly(adenosine diphosphate-ribose) polymerase. (1987) (59)
- Inheritance of immunoglobulin M rheumatoid-factor idiotypes. (1980) (59)
- Methylthioadenosine phosphorylase deficiency in human non-small cell lung cancers. (1993) (59)
- Distinct patterns of heavy chain variable region subgroup use by human monoclonal autoantibodies of different specificity (1988) (58)
- Isolation and characterization of human VkIII germ-line genes. Implications for the molecular basis of human VkIII light chain diversity. (1987) (58)
- Characterization of human rheumatoid factors with seven antiidiotypes induced by synthetic hypervariable region peptides (1985) (57)
- Anti-hypervariable region antibody induced by a defined peptide: an approach for studying the structural correlates of idiotypes. (1984) (57)
- The majority of human monoclonal IgM rheumatoid factors express a "primary structure-dependent" cross-reactive idiotype. (1985) (56)
- IgA rheumatoid factor in the sera and saliva of patients with rheumatoid arthritis and Sjögren's syndrome. (1979) (56)
- Expression of the p16 and p15 cyclin-dependent kinase inhibitors in lymphocyte activation and neuronal differentiation. (1995) (56)
- IMMUNOCHEMICAL ANALYSIS OF THE IDIOTYPES OF MOUSE MYELOMA PROTEINS WITH SPECIFICITY FOR LEVAN OR DEXTRAN (1974) (56)
- Age-associated changes in Epstein-Barr virus-induced human lymphocyte autoantibody responses. (1981) (55)
- 2-Chlorodeoxyadenosine dose escalation in nonhematologic malignancies. (1993) (55)
- Human monoclonal rheumatoid factors derived from the polyclonal repertoire of rheumatoid synovial tissue: Incidence of cross‐reactive idiotopes and expression of VH and Vϰ subgroups (1990) (55)
- Deficiency of methylthioadenosine phosphorylase in human leukemic cells in vivo. (1982) (55)
- Assignment of the gene for methylthioadenosine phosphorylase to human chromosome 9 by mouse-human somatic cell hybridization. (1984) (53)
- A methylthioadenosine phosphorylase (MTAP) fusion transcript identifies a new gene on chromosome 9p21 that is frequently deleted in cancer (2000) (53)
- Inhibition of IgE antibody formation by plasmid DNA immunization is mediated by both CD4+ and CD8+ T cells. (1997) (53)
- The expressed T cell receptor V gene repertoire of rheumatoid arthritis monozygotic twins: Rapid analysis by anchored polymerase chain reaction and enzyme‐linked immunosorbent assay (1993) (52)
- Release of lymphokines after infection with Epstein Barr virus in vitro. II. A monocyte-dependent inhibitor of interleukin 1 downregulates the production of interleukin 2 and interferon-gamma in rheumatoid arthritis. (1986) (52)
- Metabolism of C4 and factor B in rheumatoid arthritis. Relation to rheumatoid factor. (1980) (52)
- Irreversible Electroporation Combined with Checkpoint Blockade and TLR7 Stimulation Induces Antitumor Immunity in a Murine Pancreatic Cancer Model (2019) (52)
- Studies of HIV infection and the development of Epstein-Barr virus-related B cell lymphomas following transfer of human lymphocytes to mice with severe combined immunodeficiency. (1989) (51)
- Induction of antibodies to a kappa V region by gene immunization. (1993) (51)
- Antibody to the rheumatoid arthritis nuclear antigen. Its relationship to in vivo Epstein-Barr virus infection. (1980) (51)
- Peripheral deletion of rheumatoid factor B cells after abortive activation by IgG. (1997) (50)
- CD5-positive B-cell malignancies frequently express cross-reactive idiotypes associated with IgM autoantibodies. (1990) (49)
- Structural characterization of human monoclonal cold agglutinins: Evidence for a distinct primary sequence‐defined VH4 idiotype (1990) (48)
- The glycine-alanine repeating region is the major epitope of the Epstein-Barr nuclear antigen-1 (EBNA-1). (1987) (48)
- Identification of human tumour suppressor genes by monochromosome transfer: rapid growth-arrest response mapped to 9p21 is mediated solely by the cyclin-D-dependent kinase inhibitor gene, CDKN2A (p16INK4A). (1996) (45)
- The role of the T3 molecular complex in antigen recognition and subsequent activation events. (1984) (45)
- Human immunoglobulin (IgG) induced deletion of IgM rheumatoid factor B cells in transgenic mice (1995) (44)
- T lymphocyte-mediated cytotoxicity against autologous EBV-genome-bearing B cells. (1981) (44)
- 2-Chlorodeoxyadenosine chemotherapy triggers programmed cell death in normal and malignant lymphocytes. (1991) (44)
- Transfer of human chronic lymphocytic leukemia to mice with severe combined immune deficiency. (1992) (43)
- An infectious origin of extraskeletal calcification. (1998) (43)
- Immunoglobulin V Gene Expression in CD5 B‐Cell Malignancies a (1992) (42)
- Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7. (2008) (42)
- Repression of beta-catenin function in malignant cells by nonsteroidal antiinflammatory drugs. (2005) (42)
- Targeting the Wnt/beta-catenin pathway with the antifungal agent ciclopirox olamine in a murine myeloma model. (2011) (41)
- Biochemical genetic analysis of indanocine resistance in human leukemia. (2001) (41)
- Human endothelial cells produce IL-6. Lack of responses to exogenous IL-6. (1989) (40)
- Importance of Toll-Like Receptor 9 in Host Defense against M1T1 Group A Streptococcus Infections (2011) (39)
- Cellular requirements for pokeweed mitogen-induced autoantibody production rheumatoid arthritis. (1980) (39)
- Inhibition of HER-kinase activation prevents ERK-mediated degradation of PPARgamma. (2004) (39)
- Cloning and sequence determination of a human rheumatoid factor light-chain gene. (1986) (38)
- Competitive RT-PCR ELISA: a rapid, sensitive and non-radioactive method to quantitate cytokine mRNA. (1994) (38)
- The incidence of a new human cross-reactive idiotype linked to subgroup VHIII heavy chains. (1990) (38)
- Characterization of an epibody. An antiidiotype that reacts with both the idiotype of rheumatoid factors (RF) and the antigen recognized by RF (1985) (38)
- Microtiter format gene quantification by covalent capture of competitive PCR products: application to HIV-1 detection. (1993) (38)
- Two different rheumatoid factor-producing cell populations distinguished by the mouse erythrocyte receptor and responsiveness to polyclonal B cell activators. (1983) (37)
- Possible deletion of a developmentally regulated heavy-chain variable region gene in autoimmune diseases. (1990) (37)
- Enhancement of the Immunostimulatory Activity of a TLR7 Ligand by Conjugation to Polysaccharides. (2015) (37)
- NOTCH1 Signaling Promotes Human T-Cell Acute Lymphoblastic Leukemia Initiating Cell Regeneration in Supportive Niches (2012) (36)
- Targeting Wnt pathway in lymphoma and myeloma cells (2009) (36)
- Autoantigen inhibits apoptosis of a human B cell leukemia that produces pathogenic rheumatoid factor. (1993) (36)
- Biochemical genetic analysis of the role of methylthioadenosine phosphorylase in a murine lymphoid cell line. (1983) (35)
- Genetic factors in the etiology and pathogenesis of autoimmunity 1 (1992) (35)
- From human autoantibodies to the fetal antibody repertoire to B cell malignancy: it's a small world after all. (1990) (35)
- Selection of oligonucleotide aptamers with enhanced uptake and activation of human leukemia B cells. (2003) (35)
- Genetic control of T cell receptor BJ gene expression in peripheral lymphocytes of normal and rheumatoid arthritis monozygotic twins. (1996) (34)
- Molecular characterization of a supratypic cross-reactive idiotype associated with IgM autoantibodies. (1991) (34)
- Relative reactivities of rheumatoid factors in serum and cells. Evidence for a selective deficiency in serum rheumatoid factor. (1978) (34)
- Rational design, synthesis and structure-activity relationships of antitumor (E)-2-benzylidene-1-tetralones and (E)-2-benzylidene-1-indanones. (2000) (34)
- Substituted xanthines, pteridinediones, and related compounds as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha. (1996) (34)
- Pyrimidine nucleotide and nucleic acid synthesis in human monocytes and macrophages. (1991) (33)
- Synthesis and characterization of PEGylated toll like receptor 7 ligands. (2011) (33)
- 5-Aza-2'-deoxycytidine leads to down-regulation of aberrant p16INK4A RNA transcripts and restores the functional retinoblastoma protein pathway in hepatocellular carcinoma cell lines. (2000) (32)
- Sequence analyses of three immunoglobulin G anti-virus antibodies reveal their utilization of autoantibody-related immunoglobulin Vh genes, but not V lambda genes. (1992) (32)
- Characterization of an adenosine 5'-triphosphate- and deoxyadenosine 5'-triphosphate-activated nucleotidase from human malignant lymphocytes. (1982) (32)
- A systematic approach to defining the germline gene counterparts of a mutated autoantibody from a patient with rheumatoid arthritis. (1992) (32)
- 9-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)guanine: a metabolically stable cytotoxic analogue of 2'-deoxyguanosine. (1986) (32)
- The internal image of IgG in cross-reactive anti-idiotypic antibodies against human rheumatoid factors. (1983) (32)
- Idiotypic and genetic studies of human rheumatoid factors. (1987) (32)
- Synthesis of 2',3'-dideoxynucleosides by enzymatic trans-glycosylation. (1988) (32)
- Deoxyadenosine-resistant human T lymphoblasts with elevated 5'-nucleotidase activity. (1991) (31)
- Differential regulation of polyamine synthesis and transmethylation reactions in methylthioadenosine phosphorylase deficient mammalian cells. (1985) (31)
- Genetic and epigenetic profiling of CLL disease progression reveals limited somatic evolution and suggests a relationship to memory-cell development (2015) (31)
- Lymphocyte dysfunction caused by deficiencies in purine metabolism. (1981) (31)
- Population and family studies of three disease-related polymorphic genes in systemic lupus erythematosus. (1995) (30)
- Metabolism to methionine and growth stimulation by 5'-methylthioadenosine and 5'-methylthioinosine in mammalian cells. (1983) (30)
- Membrane antigen on Epstein--Barr virus-infected human B cells recognized by a monoclonal antibody. (1982) (30)
- Autoantibody-encoding kappa L chain genes frequently rearranged in lambda L chain-expressing chronic lymphocytic leukemia. (1991) (30)
- Biased estimates of clonal evolution and subclonal heterogeneity can arise from PCR duplicates in deep sequencing experiments (2014) (29)
- Light chain heterogeneity of 19S and 7S anti-gamma-globulins in rheumatoid arthritis and subacute bacterial endocarditis. (1978) (29)
- The specificity of anti-DNA antibodies in systemic lupus erythematosus. (1991) (28)
- Greatly enhanced inhibition of human immunodeficiency virus type 1 replication in CEM and HT4-6C cells by 3'-deoxythymidine diphosphate dimyristoylglycerol, a lipid prodrug of 3'-deoxythymidine (1992) (28)
- Selective induction of autoantibody secretion in human bone marrow by Epstein Barr virus. (1982) (28)
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- A polymerase chain reaction-based method for isolation of gene-specific sequences from the interferon-alpha gene cluster. (1992) (0)
- Sa1651 TLR7 Signaling As a Mechanism and Therapeutic Target for Mouse Model of Alcoholic Hepatitis (2016) (0)
- INCREASED LEVEL OF RIBONUCLEOTIDE REDUCTASE IN DEOXY ADENOSINE RESISTANT ADENOSINE DEAMINASE DEFICIENT HUMAN HISTIOCYTIC LYMPHOMA CELLS: 44 (1985) (0)
- Systemic immunological effects ofcytokine genesinjected into skeletal muscle (immune modulation/gene delivery) EYALRAZ*,AKIRAWATANABE*, STEPHENM.BAIRDt, ROBERTA.EISENBERGt, TYLERB.PARR*, (1993) (0)
- Repression of (cid:1) -catenin function in malignant cells by nonsteroidal antiinflammatory drugs (2005) (0)
- Immunochemical Analysis of the Cross-Re Proteins with Anti-Dextran Activity and N (2016) (0)
- Abstract 1848: Targeting FZD7-positive cancers using a novel antibody-drug conjugate (2021) (0)
- IMMUNOCHEMICAL ANALYSIS OF THE I DIOTYPES OF MOUSE MYELOMA PROTEINS W ITH S PECIFICITY FOR LEVAN OR DEXTRAN (1974) (0)
- 17 PROFOUND TOXICITY OF DEOXYADENOSINE (dAdo) AND 2-CHLORODEOXYADENOSINE (CdA) TOWARD HUMAN MONOCYTES IN VITRO AND IN VIVO (1988) (0)
- 2-halo-2',3'-dideoxyadenosines: metabolically stable dideoxynucleosides with activity against the human immunodeficiency virus (HIV). (1989) (0)
- 5′-DEOXY–5′-METHYLTHIOADENOSINE (MTA) PHOSPHORYLASE DEFICIENCY IN LEUKEMIA: GENETICS AND BIOCHEMICAL ASPECTS: 28 (1985) (0)
- HUMAN MALIGNANT T CELLS AND B CELLS IN TISSUE CULTURE (1980) (0)
- CHECKPOINT INHIBITION WITH SYSTEMIC ANTI‐PROGRAMMED CELL DEATH LIGAND‐1 AND INTRAVESICAL TMX‐101 DECREASE TUMOR BURDEN IN A MOUSE MODEL OF UROTHELIAL CARCINOMA: MP98‐05 (2017) (0)
- Autoantigen Dependent on CD 40 Signaling and Human Rheumatoid Factor Production (1999) (0)
- An innovative system for 3 D clinical photography in the resource-limited settings (2014) (0)
- Response to Proinflammatory Cytokines Cell-Activating Factor of the TNF Family in Mesenchymal Origin Express Functional B Fibroblast-Like Synoviocytes of (2004) (0)
- Cancer monitoring with nanoparticles and microfluidics (2008) (0)
- Are Rheumatoid Factors Produced During Conventional Immune Responses Beneficial to the Host? (2019) (0)
- Association of Autoantigenic Epitope and Catalytic Site on Poly (ADP-Ribose) Polymerase (1989) (0)
- affecting the mitochondria lymphocytic leukemia cells by damaging the DNA and by directly Deoxyadenosine analogs induce programmed cell death in chronic (2013) (0)
- Tecfidera Modulates Activation of Malignant B-Cells: Correlative Analysis from a Phase 1 Clinical Trial in Patients with Chronic Lymphocytic Leukemia (2018) (0)
- A method for selectively methioninentzug for malignant mammalian cells (1994) (0)
- 647 TLR7 Signaling As Potential Therapeutic Target for Mouse Model of Alcoholic Hepatitis (2015) (0)
- Immunoglobulin gene expression in systemic rheumatic diseases. (1991) (0)
- Biased estimates of clonal evolution and subclonal heterogeneity can arise from PCR duplicates in deep sequencing experiments (2014) (0)
- Author response: Selective activation of FZD7 promotes mesendodermal differentiation of human pluripotent stem cells (2020) (0)
- 171 UTILIZATION OF 2′-DEOXYNAD FOR ADP-RIBOSE TRANSFER REACTIONS (1988) (0)
- The importance of methylthioadenosine phosphorylase deficiency in human malignancy (1982) (0)
- Jarvis Edwin Seegmiller, MD, 1920–2006 (2006) (0)
- Expression vectors induce antigen-specific immune response and methods for their use. (1997) (0)
- Role of Rheumatoid Factor B Cells in Normal and Pathologic Antigen Presentation (1999) (0)
- Inhibition Of Wnt Signaling In Chronic Lymphocytic Leukemia Has Synergistic Cytotoxicity With Ibrutinib (2013) (0)
- Optimized NSAIDs for Breast Cancer Prevention (2006) (0)
- Cloning and sequence determination of a human rheumatoid factor light-chain gene ( human hybridoma / idiotypes / chronic lymphatic leukemia ) (2003) (0)
- Gene Vaccinat ion with Naked P lasmid (2003) (0)
- Oxidative Stress Response and Cytotoxicity of Electrophilic Compounds in Primary Human Chronic Lymphocytic Leukemia. (2009) (0)
- Induction of Anti-RF Antibodies with PGL 1 Peptide 325 (2003) (0)
- Intradermal geneimmunization: Thepossible roleofDNA uptake intheinduction ofcellular immunity toviruses (1994) (0)
- Possible metabolic basis forthedifferent immunodeficient states associated withgenetic deficiencies ofadenosine deaminase andpurine nucleoside phosphorylase (deoxyadenosine/deoxyguanosine/adenosylhomocysteine/lymphocytes) (1982) (0)
- Bacterial Lipopolysaccharide Copurifies with P l a s m i d D N A : Implications for A n i m a l (2008) (0)
- Rational Design, Synthesis, and Structure—Activity Relationships of Antitumor (E)-2-Benzylidene-1-tetralones and (E)-2-Benzylidene-1-indanones. (2000) (0)
- Epigenetic modulation enhances vaccine efficacy (2008) (0)
- Cross-Reactive Idiotypes of Rheumatoid Factors in Arthritis and Related Diseases (2020) (0)
- THE NATURE OF AUTOIMMUNE-DISEASE - GENERAL DISCUSSION (1987) (0)
- Targeting Of Chronic Lymphocytic Leukemia B Cells With a Humanized Monoclonal Antibody Specific For ROR1 (2013) (0)
- Guanosine Analogue in the Pyrido[2,3-d]pyrimidine Ring System as a Potential Toll-Like Receptor Agonist. (2007) (0)
- NCI NanoTumor Center at UCSD (2007) (0)
- Brief Definitive Report in Vitro Effects of Epstein-barr Virus on Peripheral Blood Mononuclear Cells from Patients with Rheumatoid Arthritis and Normal Subjects* (0)
- Dependent upon Mast Cells and IL-1 Bisphosphonate-Induced Inflammation Is Cutting Edge: Nitrogen (2017) (0)
- Abstract 2568: Application of novel phospholipid conjugated Toll like receptor 7 ligands for cancer therapy by topical and systemic administration (2014) (0)
- 173 ADENOSINE DEAMINASE ACTIVITY IN RECIPIENTS OF BONE MARROU FROM IMMUNODEFICIENT MICE HOMOZYGOUS FOR THE WASTED MUTATION (1988) (0)
- Increased Activity of Aldehyde Dehydrogenase, a Stem/Progenitor Cell Marker, in Chronic Lymphocytic Leukemia, (2011) (0)
- 23 Human T-T H ybridomas Specific for Epstein-Barr (1985) (0)
- A polymorphic region defined by pCN2 (the 3′ nontranslated region of N-ras) maps to chromosome 9cen-p12 (1991) (0)
- Infection and Immunity: Mechanisms of Immunodeficiency in Inborn Errors of Purine Metabolism (1985) (0)
- Selective Inhibition of Activated B-Cell Lymphoma Cells by a Novel Small Molecule Inhibitor of NF-κB (2011) (0)
- Human T-T Hybridomas Specific for Epstein—Barr Virus (1985) (0)
- Comment on Venables letter (1984) (0)
- A sensitive array-based assay to identify multiple TMPRSS2:ERG fusion variants in prostate cancer (2008) (0)
- Abstract 206: Depletion of ovarian cancer initiating cells by a monoclonal antibody against ROR1 (2014) (0)
- polypnea in mice Central histamine contributed to temperature-induced (2015) (0)
- Assay of anti-Epstein-Barr virus nuclear antigen antibodies with synthetic polypeptides (1990) (0)
- [Rheumatoid factors]. (1982) (0)
- MECHANISM OF ADENOSINE TOXICITY TO ADENOSINE KINASE DEFICIENT MAMMALIAN CELLS: 30 (1985) (0)
- adenine derivatives as therapeutic agents usable substituted. (1989) (0)
- Changes in deoxyadenosine production during human lymphocyte mitogenesis. (1984) (0)
- Perspectives NewRoles for Rheumatoid Factor (2013) (0)
- Methylthioadenosine Phosphorylase eDNA Transfection Alters Sensitivity to Depletion of Purine and Methionine in A 549 Lung Cancer Cells ' (0)
- Isolation of cancer-specific CDKN2A breakpoint fusion sequences in the presence of contaminating normal DNA (2006) (0)
- Conjugates of synthetic TLR agonists and their uses (2008) (0)
- Transforming growth factor f8andnoncytopathic mechanisms of immunodeficiency inhumanimmunodeficiency virus infection (1990) (0)
- Pharmacologic Modulation of STAT1 and Wnt Signaling in Chronic Lymphocytic Leukemia (2015) (0)
- Covalent coupling of a novel TLR7 agonist to antigen elicits an effective immune response in a murine melanoma tumor model (2007) (0)
- Editorial: Wnt Signaling in Immune Cell Regulation During Microbial Infection and Cancer (2020) (0)
- 181 CHARACTERIZATION OF POLY(ADP-RIBOSE) POLYMERASE WITH HUMAN AUTOANTIBODIES (1988) (0)
- Progress in Clinical Immunology. Volume 4. Edited by Robert S. Schwartz, MD, New York, Grune and Stratton, Inc., 1980. 179 pages. Illustrated. $23.50 (1982) (0)
- 180 MODULATION OF DIPHTHAMIDE SYNTHESIS BY METHYLTHIOADENOSINE (1988) (0)
- Heterogeneity of the toxic mechanisms of methylthioadenosine in methylthioadenosine phosphorylase deficient murine lymphoma cells. (1989) (0)
- A cross reactive idiotype on rheumatoid factor is found in Sjogren's syndrome patients in different parts of the world (1989) (0)
- Influence the Course of Adjuvant Arthritis Immunostimulatory DNA Sequences (2001) (0)
- Substituted adenine derivatives and pharmaceutical compositions containing them and the use of substituted adenine derivatives for the manufacture of medicaments (1989) (0)
- In Appreciation of William J. Koopman, MD editor, arthritis and rheumatism, 1985–90 (1990) (0)
- [Modulation of immunocompetent cells in the synovial fluid TGF-beta]. (1991) (0)
- BIOCHEMICAL BASIS FOR DEOXYADENOSINE AND 2-CHLORODEOXYADENOSINE TOXICITY TO BESTING HDMAN LYMPHOCYTES: 187 (1985) (0)
- Differential Expression Profile of the Proteome and Transcriptome in Aggressive and Indolent Chronic Lymphocytic Leukemia. (2005) (0)
- Abstract 489: Buoyant targeted microbubble technology provides efficient and superior quality of hematopoietic stem cells isolated from umbilical cord blood (2020) (0)
- The Immune Response to Glycine-Rich Sequences of Epstein-Barr Nuclear Antigen-1 (EBNA-1) in Autoimmunity: B and T Cell Epitopes (1989) (0)
- Gene immunization for the induction of antigen-specific, non MHC-restricted responses (1998) (0)
- And substituted adeninderivat anvaendbara som substanser therapeutic efficacy. (1989) (0)
- Tcl-1 Inhibits Nuclear Export of TR3 and Is Highly Expressed in ZAP70-Positive CLL B-Cells. (2004) (0)
- The Role of Immunostimulatory DNA Sequences in Arthritis (2002) (0)
- Increased level of ribonucleotide reductase in deoxyadenosine resistant adenosine deaminase deficient human histiocytic lymphoma cells. (1986) (0)
- Expression of the pl 6 and pl 5 Cyclin-dependent Kinase Inhibitors in Lymphocyte Activation and Neuronal Differentiation 1 (2006) (0)
- Molecular Basis of Epibody Reactivity (2018) (0)
- 19 2-HALO-2′,3′-DIDEOXYADENOSINES: METABOLICALLY STABLE DIDEOXYNUCLEOSIDES WITH ACTIVITY AGAINST THE HUMAN IMMUNODEFICIENCY VIRUS (HIV) (1988) (0)
- Action mechanisms and anti-lymphoma properties of Neplanocin A (1987) (0)
- Bioluminescent Monitoring of Microenvironmental Effects on Multiple Myeloma Engraftment In a Humanized Mouse Model (2010) (0)
- Award Number: W81XWH-04-1-0453 TITLE: Optimized NSAIDs for Breast Cancer Prevention (2007) (0)
- Detection of p16 gene deletions in gliomas: Fish vs. quantitative PCR (1997) (0)
- Title Pages / Table of Contents (2013) (0)
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