David H. Beach
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David H. Beachbiology Degrees
Biology
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#10979
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Cell Biology
#302
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#310
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Molecular Biology
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#991
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Neuroscience
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#1118
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Biology
David H. Beach's Degrees
- PhD Molecular Biology Stanford University
- Bachelors Biochemistry University of California, Berkeley
Why Is David H. Beach Influential?
(Suggest an Edit or Addition)David H. Beach's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a (1997) (4862)
- A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 (1993) (3888)
- p21 is a universal inhibitor of cyclin kinases (1993) (3614)
- An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells (2000) (3128)
- The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA (1994) (1771)
- Tumour biology: Senescence in premalignant tumours (2005) (1426)
- Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD (1995) (1247)
- A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma (1995) (1205)
- p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. (1995) (1140)
- Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. (1996) (980)
- Regulation of NF-κB by Cyclin-Dependent Kinases Associated with the p300 Coactivator (1997) (793)
- The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis (1988) (768)
- p21-containing cyclin kinases exist in both active and inactive states. (1994) (719)
- Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair (1994) (699)
- A Proinflammatory Cytokine Inhibits P53 Tumor Suppressor Activity (1999) (665)
- Myc activates telomerase. (1998) (665)
- Targeting CDK4 and CDK6: From Discovery to Therapy. (2016) (648)
- p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. (1994) (618)
- Glycolytic enzymes can modulate cellular life span. (2005) (615)
- cdc2 protein kinase is complexed with both cyclin A and B: Evidence for proteolytic inactivation of MPF (1989) (609)
- Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation. (1993) (579)
- Mutations and altered expression of p16INK4 in human cancer. (1994) (577)
- Twist is a potential oncogene that inhibits apoptosis. (1999) (575)
- Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins. (1993) (500)
- cdc2 is a component of the M phase-specific histone H1 kinase: Evidence for identity with MPF (1988) (488)
- Cyclin G is a transcriptional target of the p53 tumor suppressor protein. (1994) (472)
- Shared role of the pRB-related p130 and p107 proteins in limb development. (1996) (470)
- The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells (1989) (408)
- Inhibition of ras-induced proliferation and cellular transformation by p16INK4 (1995) (406)
- Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes. (1993) (380)
- Functionally homologous cell cycle control genes in budding and fission yeast (1982) (377)
- The fission yeast cdc2/cdc13/suc1 protein kinase: Regulation of catalytic activity and nuclear localization (1989) (363)
- Four mating‐type genes control sexual differentiation in the fission yeast. (1988) (347)
- Polycomb CBX7 has a unifying role in cellular lifespan (2004) (346)
- High-frequency transformation of the fission yeast Schizosaccharomyces pombe (1981) (336)
- Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2. (1990) (325)
- A high glycolytic flux supports the proliferative potential of murine embryonic stem cells. (2006) (315)
- Monitoring Tumorigenesis and Senescence In Vivo with a p16 INK4a -Luciferase Model (2013) (305)
- Mutations associated with familial melanoma impair p16INK4 function (1995) (288)
- Cyclin is a component of the sea urchin egg M‐phase specific histone H1 kinase. (1989) (280)
- Growth-regulated expression of D-type cyclin genes in human diploid fibroblasts. (1992) (279)
- p16INK4A and p19ARF act in overlapping pathways in cellular immortalization (2000) (278)
- Repression of cyclin D1: a novel function of MYC. (1994) (271)
- cdt1 is an essential target of the Cdc10/Sct1 transcription factor: requirement for DNA replication and inhibition of mitosis. (1994) (258)
- 14-3-3 proteins associate with cdc25 phosphatases. (1995) (256)
- Construction of an improved host strain for two hybrid screening. (1994) (256)
- Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate (1988) (242)
- Involvement of cdc13+ in mitotic control in Schizosaccharomyces pombe: possible interaction of the gene product with microtubules. (1988) (227)
- The product of the mei3+ gene, expressed under control of the mating‐type locus, induces meiosis and sporulation in fission yeast. (1987) (221)
- Myc confers androgen-independent prostate cancer cell growth. (2003) (202)
- p34cdc2-mediated phosphorylation at T124 inhibits nuclear import of SV- 40 T antigen proteins (1991) (201)
- Distinct nuclear and spindle pole body populations of cyclin–cdc2 in fission yeast (1990) (196)
- Cloning and characterization of murine p16INK4a and p15INK4b genes. (1995) (195)
- Deletion of the p16 and p15 genes in human bladder tumors. (1995) (194)
- Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins. (1992) (189)
- p53-Independent Role of MDM2 in TGF-β1 Resistance (1998) (183)
- p16(Ink4a) in melanocyte senescence and differentiation. (2002) (175)
- Role of the chromobox protein CBX7 in lymphomagenesis (2007) (167)
- CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus (2005) (167)
- Involvement of a type 1 protein phosphatase encoded by bws1 + in fission yeast mitotic control (1989) (162)
- Subcellular distribution of p21 and PCNA in normal and repair-deficient cells following DNA damage (1996) (155)
- Interaction between cdc13+ and cdc2+ in the control of mitosis in fission yeast; dissociation of the G1 and G2 roles of the cdc2+ protein kinase. (1987) (154)
- Multiple microRNAs rescue from Ras-induced senescence by inhibiting p21Waf1/Cip1 (2010) (152)
- Genes required for initiation and resolution steps of mating-type switching in fission yeast. (1984) (145)
- Cell type switching by DNA transposition in fission yeast (1983) (143)
- A complex containing p34cdc2 and cyclin B phosphorylates the nuclear lamin and disassembles nuclei of clam oocytes in vitro (1991) (138)
- KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases. (1994) (138)
- A whole genome screen for HIV restriction factors (2011) (137)
- Interaction between ran1+ protein kinase and cAMP dependent protein kinase as negative regulators of fission yeast meiosis. (1991) (133)
- Cyclin in fission yeast (1988) (133)
- Rearrangements of the transposable mating‐type cassettes of fission yeast. (1984) (132)
- A specific inhibitor of the ran1+ protein kinase regulates entry into meiosis in Schizosaccharomyces pombe (1988) (123)
- Immortalization of primary human prostate epithelial cells by c-Myc. (2005) (122)
- Site-specific mutagenesis of cdc2+, a cell cycle control gene of the fission yeast Schizosaccharomyces pombe (1986) (122)
- Involvement of ras in sexual differentiation but not in growth control in fission yeast (1986) (119)
- Activation of M-phase-specific histone H1 kinase by modification of the phosphorylation of its p34cdc2 and cyclin components. (1990) (114)
- A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2 (1999) (113)
- p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A (1996) (111)
- Isolation of chromosomal origins of replication in yeast (1980) (108)
- Targeting CDK 4 and CDK 6 : From Discovery to Therapy (2015) (107)
- cdc2 and the regulation of mitosis: six interacting mcs genes. (1989) (105)
- MaRX: An Approach to Genetics in Mammalian Cells (1999) (102)
- Vectors for the construction of gene banks and the integration of cloned genes in Schizosaccharomyces pombe and Saccharomyces cerevisiae. (1986) (101)
- Cell biology: Risky immortalization by telomerase (2000) (94)
- Identification of seven new cut genes involved in Schizosaccharomyces pombe mitosis. (1993) (94)
- The fission yeast cell cycle control gene cdc2: isolation of a sequence suc1 that suppresses cdc2 mutant function (1986) (91)
- RAN1+ controls the transition from mitotic division to meiosis in fission yeast (2004) (89)
- Alteration of cell cycle kinase complexes in human papillomavirus E6- and E7-expressing fibroblasts precedes neoplastic transformation (1996) (85)
- Fission yeast enters the stationary phase G0 state from either mitotic G1 or G2 (1986) (85)
- Construction of a Schizosaccharomyces pombe gene bank in a yeast bacterial shuttle vector and its use to isolate genes by complementation (2004) (83)
- Human p53 inhibits growth in Schizosaccharomyces pombe (1992) (72)
- p53-independent role of MDM2 in TGF-beta1 resistance. (1998) (72)
- Cell cycle regulation of histone H1 kinase activity associated with the adenoviral protein E1A. (1991) (69)
- Homology between the ran1+ gene of fission yeast and protein kinases. (1986) (66)
- Characterization of the fission yeast mcs2 cyclin and its associated protein kinase activity. (1993) (64)
- Cellular senescence mediated by p16INK4A-coupled miRNA pathways (2013) (61)
- Loss-of-function genetics in mammalian cells: the p53 tumor suppressor model. (2000) (60)
- Primary cilium-dependent and -independent Hedgehog signaling inhibits p16(INK4A). (2010) (60)
- Cellular senescence bypass screen identifies new putative tumor suppressor genes (2008) (58)
- Screening for antimitotic compounds using the cdc25 tyrosine phosphatase, an activator of the mitosis-inducing p34cdc2/cyclin Bcdc13 protein kinase. (1992) (56)
- Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3). (1995) (53)
- Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes. (1994) (51)
- p 53-Dependent and independent expression of p 21 during cell growth , differentiation , and DNA damage (2007) (49)
- Molecular rearrangement of mating-type genes in fission yeast (1982) (48)
- Ageing as developmental decay: insights from p16(INK4a.). (2014) (45)
- Cloning and characterization of murine p16(INK4a) and p15(INK4b) genes (1995) (43)
- Chromosomal mapping of the genes for the human CDK2/cyclin A-associated proteins p19 (SKP1A and SKP1B) and p45 (SKP2). (1996) (42)
- Suppression of growth in vitro and tumorigenicity in vivo of human carcinoma cell lines by transfected p16INK4 (1996) (39)
- p21 is a component of active cell cycle kinases. (1994) (38)
- Fission yeast cyclin: subcellular localisation and cell cycle regulation (1989) (37)
- Absence of p21WAF1 cooperates with c-myc in bypassing Ras-induced senescence and enhances oncogenic cooperation (2004) (34)
- A mutation in a thioredoxin reductase homolog suppresses p53-induced growth inhibition in the fission yeastSchizosaccharomyces pombe (1996) (32)
- Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2 (2014) (31)
- The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans (2015) (29)
- Association of rat p15INK4B/p16INK4 deletions with monosomy 5 in kidney epithelial cell lines but not primary renal tumors. (1995) (27)
- Chromosome mapping of human CDC25A and CDC25B phosphatases. (1993) (25)
- Glycolysis and cellular immortalization (2005) (23)
- A mutation in a thioredoxin reductase homolog suppresses p53-induced growth inhibition in the fission yeast (1996) (22)
- Chromosomal mapping of the human genes CKS1 to 8q21 and CKS2 to 9q22. (1996) (18)
- Human p 53 is phosphorylated by p 60-cdc 2 and cyclin B-cdc 2 ( recessive oncogene / p 53 / cell cycle phosphorylation ) (17)
- pathways in cellular immortalization (2000) (16)
- Isolation of newly-initiated DNA from the early S phase of the synchronous eukaryote, Physarum polycephalum. (1980) (15)
- EMX homeobox genes regulate microphthalmia and alter melanocyte biology. (2005) (13)
- The fission yeast cell cycle control gene cdc2: structure of the cdc2 region (1985) (6)
- Multiple phosphorylated forms of the product of the fission yeast cell division cycle gene cdc2+ (1988) (5)
- Sexual differentiation is controlled by a protein kinase encoded by the ran1+ gene in fission yeast. (1985) (3)
- Advances in Brief Mutations in the p 16 @ ' @ 4 / MTS 1 / CDKN 2 , p 15 @ 4 B / MTS 2 , and p 18 Genes in Primary and Metastatic Lung Cancer ' (2006) (2)
- [Genome mapping of Schizosaccharomyces pombe]. (1993) (1)
- ISOLATION OF EUKARYOTE DNA REPLICATION ORIGINS (1980) (1)
- Frequent Deletion of Ink4a/Mts1 in Pediatric Acute Lymphoblastic-Leukemia (1994) (1)
- A Yeast System to Study Human P53 (1991) (1)
- Fission Yeast Cyclins (1991) (0)
- Association of Rat pl5INK4Blpl6INK4 Deletions with Monosomy 5 in Kidney Epithelial Cell Lines but not Primary Renal Tumors1 (2006) (0)
- Abstracts of papers presented at the 1994 Meeting on the Cell Cycle, May 18-May 22, 1994 (1994) (0)
- Subject Index, Vol. 69, 1995 (2004) (0)
- Retraction Note: CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus (2022) (0)
- Epigenetic regulation, tumorigenesis and drug-induced senescence (2004) (0)
- Sexual differentiation is controlled by a protein kinase encoded by the ran 1 positive gene in fission yeast (1986) (0)
- Isolation of . the Rbr . elated p 130 through its mteraeuon w l U l CDK 2 and eyelins (2007) (0)
- Proteines associees a cycline kinases dependantes de la cycline ckd, et utilisations qui y sont liees (1996) (0)
- Association of Rat pl 5 INK 4 Blpl 6 INK 4 Deletions with Monosomy 5 in Kidney Epithelial Cell Lines but not Primary Renal Tumors 1 (2006) (0)
- Expression of Human P53 in Fission Yeast (1991) (0)
- Isolation of .the Rb-r.elated p 130 through its mteraeuon wlUl CDK2 and eyelins (1993) (0)
- Frequent Deletion of p16*NK4a/MTSl and in Pediatric Acute Lymphoblastic Leukemia (2011) (0)
- Frequent Deletion of p 16 * NK 4 a / MTSl and i Pediatric Acute Lymphoblastic Leukemia (2002) (0)
- Human Homolog of the Fission Yeast Cdc25 Gene Is Essential for Mitosis (1991) (0)
- Editor's Note: Immortalization of Primary Human Prostate Epithelial Cells by c-Myc. (2022) (0)
- P16(Ink4) - an Specific Inhibitor of the Cdk4/Cyclin-D Kinase (1994) (0)
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