D. H. C. Williams

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D. H. C. Williams

Philosophy

#6753

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#9848

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Logic

#3875

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#5099

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D. H. C. Williams

Biology

#9156

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#12326

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Endocrinology

#109

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#120

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Cell Biology

#384

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#394

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Biochemistry

#1372

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#1495

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Philosophy
Biology

D. H. C. Williams's Degrees

Doctorate Medicine Stanford University

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D. H. C. Williams's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Increased osteoclast development after estrogen loss: mediation by interleukin-6. (1992) (719)
17 beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens. (1992) (690)
Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats. (1994) (651)
Insulin synthesis in a clonal cell line of simian virus 40-transformed hamster pancreatic beta cells. (1981) (365)
Cytoplasmic inclusion bodies in Escherichia coli producing biosynthetic human insulin proteins. (1982) (295)
The serotonin transporter: a primary target for antidepressant drugs (1998) (262)
Truncation of limonene synthase preprotein provides a fully active 'pseudomature' form of this monoterpene cyclase and reveals the function of the amino-terminal arginine pair. (1998) (257)
Loss of estrogen upregulates osteoblastogenesis in the murine bone marrow. Evidence for autonomy from factors released during bone resorption. (1998) (203)
The development of ruthenium(ii) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications. (2017) (201)
Membrane cholesterol modulates serotonin transporter activity. (2001) (171)
The metabolism of tryptophan. 2. The metabolism of tryptophan in patients suffering from cancer of the bladder. (1956) (153)
Blanching of vegetables for freezing: which indicator enzyme to choose (1986) (146)
Comparison of seven different heterologous protein expression systems for the production of the serotonin transporter. (2003) (136)
The Reproductive System, Embryonic Development, Larval Development and Metamorphosis of the Sea Urchin Heliocidaris erythrogramma (Val.) (Echinoidea : Echinometridae) (1975) (131)
Luminescent ruthenium(II) polypyridyl functionalized gold nanoparticles; their DNA binding abilities and application as cellular imaging agents. (2011) (131)
Sequential coccolith morphogenesis in Hymenomonas carterae. (1971) (122)
The Activity of the Enzymes Sulphatase and β-Glucuronidase in the Urine, Serum and Bladder Tissue (1955) (110)
Activation of NF-kappa B and induction of vascular cell adhesion molecule-1 and intracellular adhesion molecule-1 expression in human glial cells by IL-1. Modulation by antioxidants. (1994) (110)
Thrombin-induced platelet aggregation is mediated by a platelet plasma membrane-bound lectin. (1978) (104)
Evaluation of peroxyoxalate chemiluminescence for determination of enzyme generated peroxide. (1976) (100)
Heterologous expression and characterization of a "Pseudomature" form of taxadiene synthase involved in paclitaxel (Taxol) biosynthesis and evaluation of a potential intermediate and inhibitors of the multistep diterpene cyclization reaction. (2000) (96)
Comparison of concentrations of some trace, bulk, and toxic metals in the hair of normal and dyslexic children. (1981) (93)
Multiple forms and locations for the peripheral-type benzodiazepine receptor. (1996) (87)
Fibrinogen is the receptor for the endogenous lectin of human platelets (1981) (83)
Silver–zinc: status of technology and applications (1999) (82)
Interleukin-1 activates transcription factor NF kappa B in glial cells. (1993) (81)
Synthesis, spectroscopic and biological studies of a fluorescent Pt(II) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent. (2013) (79)
Isolation and characterization of insulin-like growth factor-II from human bone. (1988) (77)
Comparison of ground and aerial ultra-low volume applications of malathion against Aedes aegypti in Santo Domingo, Dominican Republic. (1990) (76)
Plasma vitamin A in patients with bronchial carcinoma. (1976) (74)
Sodium ion-dependent transporters for neurotransmitters: a review of recent developments. (1994) (73)
Two subcellular locations for peripheral-type benzodiazepine acceptors in rat liver. (1990) (70)
In vitro pharmacology of cryptophycin 52 (LY355703) in human tumor cell lines (1999) (70)
Synthesis, Biological Activity, and SARs of Pyrrolobenzoxazepine Derivatives, a New Class of Specific “Peripheral-Type” Benzodiazepine Receptor Ligands1 (1996) (69)
Ultrasensitive near-IR fluorescence detection for capillary gel electrophoresis and DNA sequencing applications. (1995) (68)
Detailed Biological Profiling of a Photoactivated and Apoptosis Inducing pdppz Ruthenium(II) Polypyridyl Complex in Cancer Cells. (2015) (67)
Photophysical and biological investigation of novel luminescent Ru(II)-polypyridyl-1,8-naphthalimide Tröger's bases as cellular imaging agents. (2012) (62)
Automated chemiluminescence method for determining the reduced form of nicotinamide adenine dinucleotide coupled to the measurement of lactate dehydrogenase activity. (1976) (61)
The polarographic estimation of steroid hormones. 5. Determination of progesterone in blood. (1951) (60)
Long-range changes in a protein antigen due to antigen-antibody interaction. (1992) (59)
In vitro Evidence of Neutral Collagenase Activity in an Invasive Mammalian Tumour (1969) (59)
Enzyme Activity in Relation to Cancer (1957) (58)
Luminescent Lanthanide Cyclen-Based Enzymatic Assay Capable of Diagnosing the Onset of Catheter-Associated Urinary Tract Infections Both in Solution and within Polymeric Hydrogels. (2017) (57)
Mechanism of monoterpene cyclization: stereochemical aspects of the transformation of noncyclizable substrate analogs by recombinant (-)-limonene synthase, (+)-bornyl diphosphate synthase, and (-)-pinene synthase. (2001) (57)
The polarographic estimation of steroid hormones. VI. Determination of individual adrenocortical hormones in human peripheral blood. (1953) (57)
Platelet plasma membrane lectin activity. (1977) (56)
Identification of Tubulin as the Molecular Target of Proapoptotic Pyrrolo-1,5-benzoxazepines (2006) (56)
Intramolecular proton transfer in the cyclization of geranylgeranyl diphosphate to the taxadiene precursor of taxol catalyzed by recombinant taxadiene synthase. (2000) (54)
Enzyme Activity in Relation to Cancer (1957) (51)
Polar lobe formation and cytokinesis in fertilized eggs of Ilyanassa obsoleta. I. Ultrastructure and effects of cytochalasin B and colchicine. (1974) (51)
On-line fluorescence lifetime determinations in capillary electrophoresis. (1995) (51)
Glycosidase activated release of fluorescent 1,8-naphthalimide probes for tumor cell imaging from glycosylated 'pro-probes'. (2016) (50)
Pyrrolo[1,5]benzoxa(thia)zepines as a new class of potent apoptotic agents. Biological studies and identification of an intracellular location of their drug target. (2005) (49)
Insecticide susceptibility of Aedes aegypti from Santo Domingo, Dominican Republic. (1991) (48)
The effect of prolonged oral contraceptive steroid use on erythrocyte glutathione peroxidase activity. (1981) (48)
Distribution, abundance, and seasonal activities of ticks collected from rodents and vegetation in South Carolina. (1998) (47)
Pyrrolo-1,5-benzoxazepines induce apoptosis in HL-60, Jurkat, and Hut-78 cells: a new class of apoptotic agents. (2000) (47)
Antiproliferative Action of Benzodiazepines in Cultured Brain Cells Is Not Mediated Through the Peripheral‐Type Benzodiazepine Acceptor (1989) (47)
Isolation, Cultivation, and Characterization of Borrelia burgdorferi from Rodents and Ticks in the Charleston Area of South Carolina (2000) (47)
Two cellular and subcellular locations for the peripheral-type benzodiazepine receptor in rat liver. (1996) (46)
Peripheral-type benzodiazepine receptors. (1997) (45)
“True” Antiandrogens—Selective Non-Ligand-Binding Pocket Disruptors of Androgen Receptor–Coactivator Interactions: Novel Tools for Prostate Cancer (2012) (44)
Self-assembly of hybrid organic-inorganic polyoxovanadates: functionalised mixed-valent clusters and molecular cages. (2012) (44)
Glucose oxidase chemiluminescence measurement of glucose in urine compared with the hexokinase method. (1976) (44)
The antidepressants maprotiline and fluoxetine have potent selective antiproliferative effects against Burkitt lymphoma independently of the norepinephrine and serotonin transporters (2010) (44)
Ultrasensitive near-infrared laser-induced fluorescence detection in capillary electrophoresis using a diode laser and avalanche photodiode. (1997) (44)
The anomalous kinetics of coupled aspartate aminotransferase and malate dehydrogenase. Evidence for compartmentation of oxaloacetate. (1976) (41)
Purification of porphobilinogen deaminase from Euglena gracilis and studies of its kinetics. (1981) (41)
The effect of anti-cancer drugs on the plasma disposition of antipyrine and the biliary excretion of phenolphthalein in the rat. (1978) (40)
The effects of diethylstilboestrol and castration on the nucleic acid and protein metabolism of rat prostate gland. (1967) (40)
Subcellular distribution of testosterone in rat prostate and its possible relationship to nuclear ribonucleic acid synthesis. (1968) (39)
Plasma and body lipids in patients with carcinoma of the breast. (1975) (39)
BubR1 Is Required for a Sustained Mitotic Spindle Checkpoint Arrest in Human Cancer Cells Treated with Tubulin-Targeting Pyrrolo-1,5-Benzoxazepines (2008) (38)
The serum levels of some trace and bulk elements in cancer patients. (1982) (38)
Flexible estrogen receptor modulators: design, synthesis, and antagonistic effects in human MCF-7 breast cancer cells. (2001) (37)
Supramolecular approach to enantioselective DNA recognition using enantiomerically resolved cationic 4-amino-1,8-naphthalimide-based Tröger's bases. (2014) (37)
Effects of estrogen and tamoxifen on serum osteocalcin levels in ovariectomized rats. (1991) (37)
Barrier spraying to control the malaria vector Anopheles albimanus: laboratory and field evaluation in the Dominican Republic (1993) (37)
Benzoxepin-derived estrogen receptor modulators: a novel molecular scaffold for the estrogen receptor. (2004) (36)
Target specific virtual screening: optimization of an estrogen receptor screening platform. (2007) (36)
Quaternarized pdppz: synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation. (2011) (36)
Subcellular distribution of some folic acid-linked enzymes in rat liver. (1965) (35)
The oxidation of tryptophan and some related compounds with persulphate. (1956) (35)
A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin (2008) (34)
Nucleic Acid Changes in Bacteroids of Rhizobium lupini During Nodule Development (1967) (33)
Leucocyte ascorbic acid and urinary hydroxyproline levels in patients bearing breast cancer with skeletal metastases. (1974) (32)
The estimation of tryptophan metabolites in the urine of patients with cancer of the bladder. (1955) (32)
In vitro screening for anticonvulsant-induced teratogenesis in neural primary cultures and cell lines (1990) (32)
In Vitro Neurotoxicity Testing (1994) (32)
Synthesis, biological activity, and SARs of pyrrolobenzoxazepine derivatives, a new class of specific "peripheral-type" benzodiazepine receptor ligands. (1996) (31)
Integration of ligand and structure-based virtual screening for the identification of the first dual targeting agent for heat shock protein 90 (Hsp90) and tubulin. (2009) (31)
Selective Induction of Apoptosis by the Pyrrolo-1,5-benzoxazepine 7-[{Dimethylcarbamoyl}oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine (PBOX-6) in Leukemia Cells Occurs via the c-Jun NH2-Terminal Kinase-Dependent Phosphorylation and Inactivation of Bcl-2 and Bcl-XL (2004) (31)
An in vitro assessment of the effect of cytotoxic drugs upon the intestinal absorption of nutrients in rats. (1979) (31)
The novel tubulin-targeting agent pyrrolo-1,5-benzoxazepine-15 induces apoptosis in poor prognostic subgroups of chronic lymphocytic leukemia. (2009) (30)
Pyrrolo-1,5-benzoxazepines induce apoptosis in chronic myelogenous leukemia (CML) cells by bypassing the apoptotic suppressor bcr-abl. (2001) (30)
Baseline data on Aedes aegypti populations in Santo Domingo, Dominican Republic. (1990) (29)
Biosynthesis of vitamin B12: Structural studies on the corriphryins from and the link with sirohydrochlorin (1977) (29)
Multiple Molecular Forms of Ficus glabrata Ficin. Their Separation and Relative Physical, Chemical, and Enzymatic Properties. (1969) (28)
Synthesis, photophysical and cytotoxicity evaluations of DNA targeting agents based on 3-amino-1,8-naphthalimide derived Tröger's bases. (2014) (28)
Reduction in the amide hydrogen exchange rates of an anti-lysozyme Fv fragment due to formation of the Fv-lysozyme complex. (1997) (28)
The subcellular location in rat kidney of the peripheral benzodiazepine acceptor. (1988) (28)
Immunocytochemical demonstration of human proinsulin chimeric polypeptide within cytoplasmic inclusion bodies of Escherichia coli. (1983) (28)
Synergistic inhibition of [3H]muscimol binding to calf-brain synaptic membranes in the presence of L-homocysteine and pyridoxal 5'-phosphate. A possible mechanism for homocysteine-induced seizures. (1983) (28)
Unexpected DNA binding properties with correlated downstream biological applications in mono vs. bis-1,8-naphthalimide Ru(II)-polypyridyl conjugates. (2015) (28)
PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells (2010) (27)
Nuclear and cytoplasmic localization of the beta-amyloid peptide (1-43) in transfected 293 cells. (1996) (27)
Sanger DNA-sequencing reactions performed in a solid-phase nanoreactor directly coupled to capillary gel electrophoresis. (1998) (27)
Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce apoptosis in multi-drug-resistant cancer cells (2010) (27)
Plasminogen activator in cultured Lewis lung carcinoma cells measured by chromogenic substrate assay. (1980) (27)
Testosterone metabolism in the rat ventral prostate. (1969) (26)
The effect of chronic alcohol intake upon the hepatic microsomal carcinogen-activation system. (1978) (26)
Quantitative electronic analysis of normal and transformed BHK21 fibroblast aggregation. (1977) (26)
The effects of the peripheral-type benzodiazepine acceptor ligands, Ro 5-4864 and PK 11195, on mitochondrial respiration. (1992) (25)
c-fos mRNA expression in rat cortical neurons during glutamate-mediated excitotoxicity. (2004) (25)
The effect of ascorbic acid (vitamin C) on two tumor cell lines in culture. (1978) (25)
Immunological studies on the rat peripheral-type benzodiazepine acceptor. (1991) (24)
Luminescent ruthenium polypyridyl complexes with extended 'dppz' like ligands as DNA targeting binders and cellular agents. (2016) (24)
Hydrolysis of peptide bonds of the oxidized B-chain of insulin by Endothia parasitica protease. (1972) (24)
Synthesis, structural characterisation and antiproliferative activity of a new fluorescent 4-amino-1,8-naphthalimide Tröger's base-Ru(ii)-curcumin organometallic conjugate. (2018) (23)
Novel pyrrolo-1,5-benzoxazepine compounds display significant activity against resistant chronic myeloid leukaemia cells in vitro, in ex vivo patient samples and in vivo (2010) (23)
Bionomic studies of the Anopheles mosquitoes of Dajabon, Dominican Republic. (1990) (23)
Kinetics of papain-catalyzed hydrolyses of neutral substrates. (1967) (23)
Biosynthesis of porphyrins and related macrocycles. Part 10. Vitamin B12: biochemical derivation of cobyrinic acid from uroporphyrinogen III. Studies with corresponding ring c methyl heptacarboxylic prophyrinogen, and proof of seven intact methyl transfers. (1977) (23)
STI-571 (Imatinib Mesylate) Enhances the Apoptotic Efficacy of Pyrrolo-1,5-Benzoxazepine-6, a Novel Microtubule-Targeting Agent, in Both STI-571-Sensitive and -Resistant Bcr-Abl-Positive Human Chronic Myeloid Leukemia Cells (2007) (22)
Antiproliferative action of pyrrolobenzoxazepine derivatives in cultured cells: absence of correlation with binding to the peripheral-type benzodiazepine binding site. (1998) (22)
The pyrrolo-1,5-benzoxazepine, PBOX-15, enhances TRAIL-induced apoptosis by upregulation of DR5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells (2016) (22)
The pyrrolo-1,5-benzoxazepine, PBOX-6, inhibits the growth of breast cancer cells in vitro independent of estrogen receptor status and inhibits breast tumour growth in vivo. (2005) (22)
Physiological and pharmacological regulation of biological calcification. (1991) (21)
Inhibition of late-stage autophagy synergistically enhances pyrrolo-1,5-benzoxazepine-6-induced apoptotic cell death in human colon cancer cells. (2013) (21)
The biochemistry of aromatic amines; the resistance of some o-aminoaryl sulphates to hydrolysis by aryl sulphatases. (1956) (21)
Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1-propenes as a new class of anticancer agents. (2011) (20)
Substrate retention of fractured retraction fibres during detachment of trypsinized BHK21 fibroblasts. (1977) (20)
Levels of cholesterol, 11-hydroxycorticosteroids and progesterone in plasma from postmenopausal women with breast cancer. (1975) (20)
Studies of enzyme-mediated reactions. Part VII. Stereospecific syntheses of tritium-labelled (2R)- and (2S)-dopamines: stereochemical course of hydroxylation of dopamine by dopamine beta-hydroxylase (E.C. 1.14.17.1). (1976) (20)
Field evaluations in malaise and canopy traps of selected targets as attractants for tabanid species (Diptera: Tabanidae). (1993) (20)
Vitamin A nutrition and its relationship with plasma cholesterol level in the patients with cancer. (1974) (20)
The novel pyrrolo-1,5-benzoxazepine, PBOX-6, synergistically enhances the apoptotic effects of carboplatin in drug sensitive and multidrug resistant neuroblastoma cells. (2014) (19)
The thiamine status of patients with cancer as determined by the red cell transketolase activity. (1974) (19)
A colorimetric assay system for tetrahydrofolate dehydrogenase. (1968) (19)
Virtual screening for the identification of novel nonsteroidal glucocorticoid modulators. (2010) (19)
Characterization of cementum derived growth factor as an insulin-like growth factor-I like molecule. (1997) (19)
Pushing the limit: synthesis, photophysical and DNA binding studies of a NIR-emitting Ru(II)-polypyridyl probe with 'light switch' behaviour. (2012) (19)
The endogenous lectin of human platelets is an alpha-granule component. (1981) (19)
The fate of intravenously injected folate in rats. (1965) (18)
Polar lobe formation and cytokinesis in fertilized eggs of Ilyanassa obsoleta. II. Large bleb formation caused by high concentrations of exogenous calcium ions. (1974) (18)
Chlorpromazine inhibits mitosis of mammalian cells. (1983) (18)
Sequential treatment with flavopiridol synergistically enhances pyrrolo-1,5-benzoxazepine-induced apoptosis in human chronic myeloid leukaemia cells including those resistant to imatinib treatment. (2010) (17)
Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. (2009) (17)
Characterization of the multiple forms of hydroxymethylbilane synthase from rat spleen. (1984) (17)
5-Hydroxytryptamine excretion in patients with carcinoma of the larynx and bronchus. (1956) (17)
Lead identification of β-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90. (2011) (17)
Hepatic function assessed (in rats) during chemotherapy with some anti-cancer drugs. (1979) (17)
Synthesis and antiproliferative action of a novel series of maprotiline analogues. (2014) (16)
Rat liver uroporphyrinogen III synthase has similar properties to the enzyme from Euglena gracilis, including absence of a requirement for a reversibly bound cofactor for activity. (1988) (16)
Malaria transmission potential by Anopheles mosquitoes of Dajabon, Dominican Republic. (1991) (15)
Novel naphthoquinones from a Streptomyces sp. (1999) (15)
The effect of ethanol ingestion on the erythrocyte antioxidant defence systems of rats. (1980) (15)
Serum galactosyl transferase levels in patients with advanced cancer. (1982) (15)
Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells (2016) (15)
Emergency control of Aedes aegypti in the Dominican Republic using the Scorpion 20 ULV forced-air generator. (1994) (15)
Immunocytochemical localization of plasminogen activator on porcine kidney cell strain: LLC-PK1 (LP100). (1979) (14)
The novel pyrrolo-1,5-benzoxazepine, PBOX-21, potentiates the apoptotic efficacy of STI571 (imatinib mesylate) in human chronic myeloid leukaemia cells. (2009) (14)
Ticks of South Carolina (Acari: Ixodoidea). (1999) (14)
Synthesis, antiproliferative and pro-apoptotic activity of 2-phenylindoles. (2016) (14)
Interleukin-1 and phorbol myristate acetate modulate the peripheral-type benzodiazepine receptor in lymphocytes and glial cells. (1993) (14)
Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce cell cycle arrest and apoptosis in prostate cancer cells. (2010) (13)
The microtubule targeting agent PBOX-15 inhibits integrin-mediated cell adhesion and induces apoptosis in acute lymphoblastic leukaemia cells. (2013) (13)
Biosynthesis of the natural (type-III) porphyrins: proof that rearrangement occurs after head-to-tail bilane formation (1977) (13)
Calmidazolium and other imidazole compounds affect steroidogenesis in Y1 cells: Lack of involvement of the peripheral-type benzodiazepine receptor (1997) (13)
Oxidative stress induces apoptosis in C6 glioma cells: Involvement of mitogen-activated protein kinases and nuclear factor kappa B (2001) (13)
The Microtubule-Targeting Agents, PBOX-6 [Pyrrolobenzoxazepine 7-[(dimethylcarbamoyl)oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine] and Paclitaxel, Induce Nucleocytoplasmic Redistribution of the Peptidyl-Prolyl Isomerases, Cyclophilin A and Pin1, in Malignant Hematopoietic Cells (2009) (13)
Caspase-activated DNase (CAD)-independent oligonucleosomal DNA fragmentation in chronic myeloid leukaemia cells; a requirement for serine protease and Mn2+-dependent acidic endonuclease activity (2006) (12)
Hexachlorocyclohexanes inhibit steroidogenesis in Y1 cells. Absence of correlation with binding to the peripheral-type benzodiazepine binding site. (1996) (12)
Biosynthesis of vitamin B12: derivation of cobyrinic acid from uroporphyrinogen-III (1975) (11)
4-Amino-1,8-naphthalimide based fluorescent photoinduced electron transfer (PET) pH sensors as liposomal cellular imaging agents: The effect of substituent patterns on PET directional quenching (2019) (11)
Survey of container-inhabiting mosquitoes in Clemson, South Carolina, with emphasis on Aedes albopictus. (1995) (11)
Binding of benzodiazepines to blood platelets from various species. (1984) (11)
Amylase, cellulase and protease activities in surface and gut tissues ofDendraster excentricus, Pisaster ochraceus andStrongylocentrotus droebachiensis (Echinodermata) (1991) (11)
The effect of overcrowding stress on carcinogen-metabolizing enzymes of the rat. (1980) (11)
Synthesis, Characterization, and Biological Profiling of Ruthenium(II)-Based 4-Nitro- and 4-Amino-1,8-naphthalimide Conjugates. (2020) (11)
Penetration of ultra-low volume applied insecticide into dwellings for dengue vector control. (1992) (11)
Lack of Effect of Methotrexate on Hepatic Regeneration (1965) (11)
Biosynthesis of vitamin B12: evidence from double-labelling studies (13CD3) for intact incorporation of seven methyl groups (1976) (11)
Purification and properties of the 3alpha-hydroxy steroid-dependent nicotinamide-adenine dinucleotide transhydrogenase of rat liver. (1963) (11)
Improvements in an in-vitro assay for excitotoxicity by measurement of early gene (c-fos mRNA) levels (2005) (11)
Kinetics of the interaction of sertraline with the human platelet plasma membrane 5-hydroxytryptamine carrier. (1988) (10)
Basic N-interlinked imipramines show apoptotic activity against malignant cells including Burkitt's lymphoma. (2013) (10)
Excretion of 5-hydroxyindole acetic acid and n1-methylnicotinamide in advanced cancer patients. (1973) (10)
PK 11195 reduces the brain availability of lindane in rats and the convulsions induced by this neurotoxic agent. (1995) (10)
Dual targeting of tumour cells and host endothelial cells by novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines (2009) (10)
The effect of isolation stress on some hepatic drug and carcinogen metabolising enzymes in rats. (1980) (10)
Regioselectivity of the insertion reactions of some aromatic diazo compound complexes with cyclomaltoheptaose. (1992) (10)
Hydrolase (β-Glucanase, α-Glucanase, and Protease) Activity in Ariolimax columbianus (Banana Slug) and Arion ater (Garden Slug) (1997) (9)
Tuluweckelia cernua , a new genus and species of stygobiont amphipod crustacean ( Hadziidae ) from anchialine caves on the Yucatan Peninsula in Mexico (9)
Dissociation and catalysis in yeast hexokinase A. (1976) (9)
The enzymic reduction of nicotinamide-adenine dinucleotide by 2-mercaptoethanol. (1965) (9)
Multiple forms of calmodulin on sodium dodecyl sulphate/polyacrylamidegel electrophoresis (1984) (9)
Water-soluble amphiphilic ruthenium(ii) polypyridyl complexes as potential light-activated therapeutic agents. (2020) (9)
Microtubule-targeting-compound PBOX-15 radiosensitizes cancer cells in vitro (2011) (9)
Stabilization of the peripheral-type benzodiazepine acceptor by specific phospholipids. (1992) (9)
Plasminogen activation transforms the morphology of quiescent 3T3 cell monolayers and initiates growth. (1979) (9)
Ascorbic acid therapy for the relief of bone pain in Paget's disease. (1978) (8)
Inter‐relationships of nutrition and cancer (1973) (8)
Visible light inhibits growth of Chinese hamster ovary cells. (1983) (8)
Effect of Alkyl Chain Length on the Photophysical, Photochemical, and Photobiological Properties of Ruthenium(II) Polypyridyl Complexes for Their Application as DNA-Targeting, Cellular-Imaging, and Light-Activated Therapeutic Agents (2021) (8)
The effect of chloroform ingestion on the growth of some murine tumours. (1979) (8)
Pyrrolo-1,5-benzoxazepines: a new class of apoptotic agents. (2001) (8)
Platelet 5‐HT uptake in post‐stroke depression (1990) (8)
Lewis Lung Carcinoma: Selecting Metastatic Variants (1980) (7)
The activity of the enzymes sulphatase and glucuronidase in the urine of normal and cancer patients. (1954) (7)
The correlation between plasminogen activator-stimulated DNA synthesis and cell morphology in 3T3 cells. (1978) (7)
Urinary hydroxyproline and plasma mucoprotein as an indication of the presence of bone metastases. (1974) (7)
Enzymic formation of the type-III prophyrin macrocycle from unrearranged AP·AP pyrromethane (1977) (7)
The effect of castration on the ribonucleic acid metabolism of an experimental prostatic tumour. (1966) (7)
Automatic cell changer for enzyme assay by recording fluorometry and its use with dihydrofolic reductase. (1965) (7)
Antisera Raised Against the Drug Imipramine (1987) (7)
Morphological changes in frog pronephric cell surfaces after transformation by herpes virus. (1976) (7)
The reception of androgens in the rat ventral prostate. (1969) (7)
[195] Dihydrofolic reductase (5,6,7,8-tetrahydrofolate: NADP oxidoreductase, EC 1.5.1.3) (1971) (7)
Synthesis and in vitro toxicity of 4-MTA, its characteristic clandestine synthesis byproducts and related sulfur substituted alpha-alkylthioamphetamines. (2010) (7)
Effects of feeding and starvation on proteolytic and tryptic activities in pyloric caecal tissues and duct fluids of the seastar Pisaster ochraceus (1985) (6)
The Metabolism of Testosterone in the Prostate (1971) (6)
A monoclonal anti-imipramine antibody with antidepressant binding properties similar to the muscarinic receptor. (1990) (6)
Endothelin‐1 Increases Arachidonic Acid Release in C6 Glioma Cells Through a Potassium‐Modulated Influx of Calcium (1996) (6)
The Peripheral‐Type Benzodiazepine Receptor Is Present in Astrocytes but Is Not a Primary Site of Action for Convulsants/Anticonvulsants (1994) (6)
The occurrence and distribution of digestive enzymes in the pyloric caecum of the purple starfish Pisaster ochraceus. (1975) (6)
Induction of apoptosis in oral squamous carcinoma cells by pyrrolo-1,5-benzoxazepines. (2015) (6)
The influence of zinc status on the anti-Lewis lung tumour activity of cisplatin and gallium. (1981) (6)
The transplantation of chemically induced steroid sensitive mammary tumours. (1965) (6)
DIEL PERIODICITY OF OVIPOSITION AND SOIL MOISTURE PREFERENCE OF PSOROPHORA COLUMBIAE1,2 (1986) (6)
First report of Ixodes (Ixodes) minor Neumann (Acari: Ixodidae) from South Carolina. (1992) (6)
Involvement of AMP-activated protein kinase in mediating pyrrolo-1,5-benzoxazepine–induced apoptosis in neuroblastoma cells (2016) (6)
Chromosomal examination of various cell clones (in vitro) derived from a DMBA (7-12 dimethyl-alpha-benzanthracene)-induced male rat breast tumour. (1973) (6)
Malathion resistance in mosquitoes from Charleston and Georgetown counties of coastal South Carolina. (1994) (6)
Chronotropic effect of tyramine on rat heart cells cultured with sympathetic neurons. (1978) (6)
The effect of chronic ethanol intake on the growth and spread of some murine tumors. (1978) (6)
The effect of prolonged ethanol intake on some carcinogen-activating enzymes in mice. (1979) (5)
Isolation, purification and partial characterization of four digestive proteases from the purple seastar Pisaster ochraceus (1988) (5)
Effects of controlled burning on Aedes taeniorhynchus eggs in an abandoned rice impoundment in South Carolina. (1990) (5)
A simple rapid purification scheme for hydroxymethylbilane synthase from human erythrocytes. (1988) (5)
The role of lysosomal enzymes in malignant growth. (1968) (5)
Correlation between tumour size, metastatic spread and galactosyl transferase activity in cyclophosphamide-treated mice bearing the Lewis lung carcinoma. (1979) (5)
In vitro screening for anticonvulsant-induced teratogenesis: Structure-activity relationships in the barbiturate and branched chain carboxylic acid classes. (1991) (5)
Studies of the susceptibility of Anopheles albimanus and Anopheles vestitipennis from Dajabon, Dominican Republic, to insecticides. (1990) (4)
The recovery of liver tetrahydrofolate dehydrogenase activity from inhibition by methotrexate. (1969) (4)
Biosynthesis of porphyrins and related macrocycles. Part 15. Chemical and enzymic formation of uroporphyrinogen isomers from unrearranged aminomethylpyrromethane: separation of isomeric coproporphyrin esters (1982) (4)
Different Specificities for Taurine Analogues and their Target Sites in Brain (1997) (4)
On the possible involvement of an anhydride intermediate in papain-catalyzed hydrolyses. (1968) (4)
Reconstitution of the rat brain serotonin transporter. (1995) (4)
Design, Synthesis and Biochemical Evaluation of Novel Ethanoanthracenes and Related Compounds to Target Burkitt’s Lymphoma (2020) (4)
In vivo Effect of an Invasive Malignant Rat Tumour on Cartilage (1967) (4)
The novel pyrrolo-1,5-benzoxazepine, PBOX-15, synergistically enhances the apoptotic efficacy of imatinib in gastrointestinal stromal tumours; suggested mechanism of action of PBOX-15 (2016) (4)
The inhibition of 3-alpha-hydroxy steroid-activated nicotinamide-adenine dinucleotide (phosphate) transhydrogenase by some antimetabolic compounds. (1964) (3)
The production and secreton of digestive enzymes in the purple seastar Pisaster ochraceus (1975) (3)
Enzyme induction by steroid hormones with reference to cancer. (1975) (3)
Some metabolic functions of liver in patients with advanced non-hepatic cancer. (1974) (3)
Biosynthesis of porphyrins and related macrocycles. Part 11. Studies on biosynthesis of the phytyl chain of chlorophyll a by use of carbon-13 (1977) (3)
Stereochemical course of hydroxylation of dopamine by dopamine-β-hydroxylase (EC1.14.17.1) (1974) (3)
Use of inverted intestinal sacs to assess the effect of gastrointestinal insult on carcinogen absorption. (1981) (3)
Dithiothreithol promotes a higher affinity state of the serotonin transporter for the tricyclic antidepressant, imipramine. (1995) (3)
Multiple affinity states for [3H]imipramine binding sites on human platelet membranes. (1984) (3)
Effect of combined immunosuppressive drug therapy on small intestinal nutrient transport in the rat. (1999) (3)
THE INHIBITION OF NICOTINAMIDE-ADENINE DINUCLEOTIDE-LINKED 3-ALPHA-HYDROXY STEROID DEHYDROGENASE BY CERTAIN ANTIMETABOLIC DRUGS. (1965) (3)
Effects of methotrexate and phenobarbital on the hepatic microsomal drug-metabolizing enzymes in normal rat. (1975) (3)
Testosterone metabolism in the rat ventral prostate. (1968) (3)
'High-affinity' peripheral-type benzodiazepine-binding sites. (1987) (3)
Selected nitrostyrene compounds demonstrate potent activity in chronic lymphocytic leukaemia cells, including those with poor prognostic markers. (2019) (3)
The relationship between 3 α-hydroxysteroid nicotinamide nucleotide coenzyme transhydrogenation and β-glucuronidase in regenerating rat liver (1964) (2)
The enzymic hydrolysis of derivatives of aminophenols. (1955) (2)
lnterleukin-1 activates transcription factor NFKB in glial cells (2005) (2)
Flit-gun sprayer characteristics. (1998) (2)
The presence of a substance with hydrogen transporting properties in some samples of methotrexate. (1968) (2)
A simple technique for the separation and estimation of 3H-labelled androgen metabolites. (1969) (2)
THE EFFECT OF TRANSPLANTED MAMMARY TUMOURS ON THE CALCIUM BALANCE OF THE RAT. (1964) (2)
Probing the platelet plasma-membrane 5-hydroxytryptamine transporter. (1991) (2)
Enrichment of rat liver and kidney ‘peripheral-type’ benzodiazepine-binding sites in plasma membrane-derived fractions (1986) (2)
Combined therapy with ascorbic acid and calcitonin for the relief of bone pain in Paget's disease. (1981) (2)
β-glucanase activity in the seastar Pisaster ochraceus (1995) (2)
Operational note indoor low-volume spray trials: handheld equipment evaluation. (2002) (2)
A new method of testing Bacillus thuringiensis var. israelensis (H-14) formulations on Aedes taeniorhynchus in an abandoned rice impoundment in South Carolina. (1989) (2)
Effect of chloroform ingestion on some carcinogen-metabolising enzyme systems of rats (1979) (2)
In vitro HIV infection of primate lymphocytes. (1990) (1)
Selective Induction of Apoptosis by PBOX-6 in Leukemia Cells occurs via the JNK Dependent Phosphorylation and Inactivation of Bcl-2 and Bcl-XL (2004) (1)
Stereochemistry of the Methyl→Methylene Elimination in the Enzyme‐Catalyzed Cyclization of Geranyl Diphosphate to (4S)‐Limonene. (1998) (1)
Pyrrolo-1,5-Benzoxazepines Induce Apoptosis in Chronic Myeloid Leukemia (CML) Cells by Bypassing the Apoptotic Suppressor BCR-ABL (2001) (1)
Effect of suramin (Bayer 205) on hepatic microsomal cytochromes P-450, b 5 , and demethylation activity in rats. (1973) (1)
The effect of triton X-100 on bovine brain synaptic membranes (1988) (1)
Blood values of some vitamins in long-stay psycho-geriatric patients. (1976) (1)
Solubilization of human platelet plasma membrane 5-hydroxytryptamine carrier with retention of native properties (1986) (1)
Ethyl side-chain modifications in novel flexible antiestrogens--design, synthesis and biological efficacy in assay against the MCF-7 breast tumor cell line. (2001) (1)
Methotrexate and alopecia. (1973) (1)
Gradient Elution Chromatography of Corticosteroids in Human Blood (2008) (1)
Fibrinolysis in lung cancer. (1978) (1)
Influence of age on isolation stress‐stimulated carcinogen‐metabolizing enzymes of rats (1981) (1)
A simplified microassay of transketolase in human blood. (1974) (1)
Pyrrolo-1,5-benzoxazepines: a new class of apoptotic agents (2001) (1)
The ‘Thiamin-Sparing’ Effect of Ascorbic Acid (1976) (1)
Interleukin-6 neutralizing antibody administration prevents osteoclastogenic response to ovariectomy in the mouse (1992) (1)
Proceedings: Urinary hydroxyproline and leucocyte ascorbic acid levels in patients bearing breast tumour with skeletal metastases. (1974) (1)
BASELINE DATA ON AEDE S AEGYPTI POPULATIONS IN SANTO DOMINGO , DOMINICAN REPUBLIC 1 (2004) (0)
HORMONE-SENSITIVITY OF PYRIDINE NUCLEOTIDE TRANSHYDROGENASES IN NORMAL AND MALIGNANT TISSUE (1960) (0)
BTONOMIC STUDIES OF TIIF " ANOPHETES MOSQUITOES OF DAJABON , DOMINICAN REPUBLIC 1 (2004) (0)
SERT biosynthesis and the problems of overexpression for structural studies (2001) (0)
Prognostic Subgroups of Chronic Lymphocytic Leukemia Pyrrolo-1 , 5-Benzoxazepine-15 Induces Apoptosis in Poor The Novel Tubulin-Targeting Agent (2009) (0)
Recurrent and Metastatic Oncological Diseases (1974) (0)
THE SELECTION AND TRANSPLANTATION OF HORMONE SENSITIVE TUMOURS (1965) (0)
Purification and properties of calmodulin-activated phosphodiesterase from bovine brain (1987) (0)
PENETRATIoN oF ULV Spnev rNro DwELLINGS PENETRATION OF ULTRA-LOW VOLUME APPLIED INSECTICIDE INTO DWELLINGS FOR DENGUE VECTOR CONTROL1 (2004) (0)
Partial purification of the human platelet 5-HT transporter and crossreactivity with antibodies to the rat brain GABA transporter (1992) (0)
68 The Biochemistry of Aromatic Amines (2005) (0)
Simultaneous application of adulticide and larvicide for mosquito control using the Scorpion 20 ULV forced air generator (1994) (0)
THE INHIBITION OF TWO STEROID-ACTIVATED NICOTINAMIDE-ADENINE DINUCLEOTIDE (PHOSPHATE) TRANSHYDROGENASES BY FOLIC ACID AND FOLIC ACID ANTIMETABOLITES. (1965) (0)
Depolarising levels of KCl inhibit endothelin-1-mediated release of arachidonic acid in rat C6 glioma cells. (1995) (0)
Estimation of Individual Adrenocortical Hormones in Human Peripheral Blood (2008) (0)
Production of rabbit anti-imipramine antibodies (1987) (0)
peripheral-type benzodiazepine acceptor (2005) (0)
Quaternarized pdppz: Synthesis, DNA-Binding and Biological Studies of a Novel dppz Derivative (I) that Causes Cellular Death upon Light Irradiation. (2011) (0)
Abstract #399: The antidepressants fluoxetine and maprotiline induce apoptosis and type-II autophagic-programmed cell death in Burkitt\#8217;s lymphoma in vitro independently of SERT and NET (2009) (0)
Subject Index, Vol. 20, 1976 (1976) (0)
281 Cancer: a less depressing outlook? Using antidepressants to induce autophagic programmed cell death in a resistant strain of Burkitt's lymphoma (2010) (0)
Molecular studies on the peripheral-type benzodiazepine acceptor. (1992) (0)
Using Enantiomerically Resolved Cationic 4 ‐ Amino-1 , 8-3 naphthalimide-Based Tröger ’ s Bases (2014) (0)
Books Received / Book Reviews (1982) (0)
Selective Induction of Apoptosis by the Pyrrolo-1,5-benzoxazepine d ] (1,5)-benzoxazepine (PBOX-6) in Leukemia Cells Occurs via the c-Jun NH 2 -Terminal Kinase-Dependent Phosphorylation and Inactivation of Bcl-2 and Bcl- XL (2004) (0)
Partial purification of the human platelet 5-HT transporter and crossreactivity with antibodies to the rat brain GABA transporter (1992) (0)
Contents, Vol. 20, 1976 (1974) (0)
The effect of chloroform inhalation on hepatic glucuronidation and de-glucuronidation mechanisms. (1980) (0)
The investigation of metastasis of endocrine tumours in bone. (1965) (0)
Steroid Hormones and Cancer (1977) (0)
Evidence for the presence of a trypsinogen-like zymogen in the tissues of the sea star Pisaster ochraceus (1982) (0)
Identification of novel ligands for the peripheral-type benzodiazepine receptor. (1995) (0)
The effect of oophorectomy on the ribonucleic acid metabolism of a transplantable uterine tumour. (1965) (0)
Quaternarized pdppz; a novel dppz derivative that causes cellular deathupon light irradiation: Synthesis, DNA-binding and biological studies (2011) (0)
831: Induction of apoptosis by pyrrolo-1,5-benzoxazepines in oral squamous carcinoma cells (2014) (0)
Pyrrolo-1,5-benzoxazepines induce apoptosis in chronic B-lymphoid malignancies (2006) (0)
Inhibition of brain cell proliferation by benzodiazepines (1986) (0)
THE RELATIONSHIP BETWEEN 3 ALPHA-HYDROXYSTEROID NICOTINAMIDE NUCLEOTIDE COENZYME TRANSHYDROGENATION AND BETA-GLUCURONIDASE IN REGENERATING RAT LIVER. (1964) (0)
Acid Changes in Bacteroids of Rhizobium Zupini During Nodule Development (2008) (0)
Synthesis and in vitro toxicity of 4-MTA , its characteristic clandestine synthesis byproducts and related sulphur substituted α-alkylthioamphetamines (2010) (0)
A novel microtubule depolymerization agent, PBOX-15, induces apoptosis in non-proliferating chronic lymphocytic leukemia cells ex vivo. (2007) (0)
933 AN IN VITRO INVESTIGATION OF THE CYTOTOXIC AND RADIO-SENSITISING PROPERTIES OF A NOVEL MICRO- TUBULE TARGETING AGENT, PBOX-15, IN HYPOXIC PROSTATE CANCER CELL LINES (2011) (0)
The University of Texas System Cancer Center M.D. Anderson Hospital and Tumor Institute (1982) (0)
The design of photo-affinity labels for the characterisation of the 5-hydroxytryptamine transporter on human platelet membranes. (1991) (0)
Towards Overexpression of the Serotonin Transporter (1997) (0)
Modulation of the peripheral-type benzodiazepene acceptor by IL1 and PMA (1992) (0)
andCastration on theNucleic Acid andProtein Metabolism ofRatProstate Gland (1967) (0)
Retraction notice to “PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines” [Eur. J. Pharmacol. 714(1–3) (2013) 379–387]. (2014) (0)
STEREOCHEMICAL COURSE OF HYDROXYLATION OF DOPAMINE BY DOPAMINE-BETA-HYDROXYLASE (EC1.14.17.1) (1974) (0)
Modulation of the serotonin transporter by membrane cholesterol (2001) (0)

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