Doyle G. Graham
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Doyle G. Grahambiology Degrees
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Neuroscience
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Biochemistry
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#2449
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Chemistry Biology
Why Is Doyle G. Graham Influential?
(Suggest an Edit or Addition)Doyle G. Graham's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones. (1978) (1174)
- Autoxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C1300 neuroblastoma cells in vitro. (1978) (951)
- Quinone chemistry and toxicity. (1992) (653)
- Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons. (1999) (614)
- On the origin and significance of neuromelanin. (1979) (223)
- Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOE4. (1997) (220)
- The Lipid Peroxidation Product 4‐Hydroxynonenal Inhibits Neurite Outgrowth, Disrupts Neuronal Microtubules, and Modifies Cellular Tubulin (1999) (176)
- Pathogenetic studies of hexane and carbon disulfide neurotoxicity. (1995) (160)
- 4‐Hydroxy‐2(E)‐Nonenal Inhibits CNS Mitochondrial Respiration at Multiple Sites (1999) (153)
- E-4-hydroxy-2-nonenal is cytotoxic and cross-links cytoskeletal proteins in P19 neuroglial cultures. (1996) (142)
- Intermediates in the Paal-Knorr synthesis of pyrroles (1991) (137)
- Studies of the molecular pathogenesis of hexane neuropathy. II. Evidence that pyrrole derivatization of lysyl residues leads to protein crosslinking. (1982) (132)
- Catecholamine toxicity: a proposal for the molecular pathogenesis of manganese neurotoxicity and Parkinson's disease. (1984) (130)
- The toxicity of melanin precursors. (1978) (126)
- Enhanced N‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine Toxicity in Mice Deficient in CuZn‐Superoxide Dismutase or Glutathione Peroxidase (2000) (110)
- The role of 2,4,5-trihydroxyphenylalanine in melanin biosynthesis. (1977) (98)
- Crosslinking of Apolipoprotein E by Products of Lipid Peroxidation (1996) (97)
- The effect of 3,4-dimethyl substitution on the neurotoxicity of 2,5-hexanedione. I. Accelerated clinical neuropathy is accompanied by more proximal axonal swellings. (1983) (90)
- Hereditary motor and sensory neuropathy, X‐linked (1987) (89)
- Neurotoxicity of Endogenous Cysteinylcatechols (1997) (88)
- The effect of 3,4-dimethyl substitution on the neurotoxicity of 2,5-hexanedione. II. Dimethyl substitution accelerates pyrrole formation and protein crosslinking. (1983) (85)
- In vitro evidence that covalent crosslinking of neurofilaments occurs in gamma-diketone neuropathy. (1984) (71)
- Sural nerve biopsy in chronic inflammatory demyelinating polyradiculoneuropathy (1989) (70)
- Pyrrole oxidation and protein cross-linking as necessary steps in the development of gamma-diketone neuropathy. (1988) (69)
- Evidence that pyrrole formation is a pathogenetic step in γ-diketone neuropathy (1987) (63)
- Covalent Crosslinking of Neurofilament Proteins by Oxidized Catechols as a Potential Mechanism of Lewy Body Formation (1995) (62)
- Secondary Excitotoxicity Contributes to Dopamine-Induced Apoptosis of Dopaminergic Neuronal Cultures☆ (1998) (58)
- The Spatio‐Temporal Pattern of the Axonopathy Associated with the Neurotoxicity of 3,4‐Dimethyl-2,5‐Hexanedione in the Rat (1983) (58)
- The relative neurotoxicities of n-hexane, methyl n-butyl ketone, 2,5-hexanediol, and 2,5-hexanedione following oral or intraperitoneal administration in hens. (1982) (54)
- Studies of the molecular pathogenesis of hexane neuropathy. I. evaluation of the inhibition of glyceraldehyde-3-phosphate dehydrogenase by 2,5-hexanedione. (1980) (53)
- Hexane neuropathy: a proposal for pathogenesis of a hazard of occupational exposure and inhalant abuse. (1980) (51)
- Infiltrative polyneuropathy due to acute monoblastic leukemia in hematologic remission (1987) (45)
- Release of carbon disulfide is a contributing mechanism in the axonopathy produced by N,N-diethyldithiocarbamate. (1998) (45)
- Ultrastructure of experimental cocaine hepatotoxicity (1986) (45)
- The measurement of 2-thiothiazolidine-4-carboxylic acid as an index of the in vivo release of CS2 by dithiocarbamates. (1996) (43)
- Delayed neurotoxicity of O-ethyl O-4-nitrophenyl phenylphosphonothioate: toxic effects of a single oral dose on the nervous system of hens. (1979) (42)
- Delayed neurotoxicity of O-ethyl O-4-nitrophenyl phenylphosphonothioate: subchronic (90 days) oral administration in hens. (1978) (41)
- Reactions of 4-hydroxy-2(E)-nonenal and related aldehydes with proteins studied by carbon-13 nuclear magnetic resonance spectroscopy. (1998) (40)
- The morphology of carbon disulfide neurotoxicity. (1985) (39)
- gamma-L-Glutaminyl-4-hydroxybenzene, an inducer of cryptobiosis in Agaricus bisporus and a source of specific metabolic inhibitors for melanogenic cells. (1977) (39)
- Increased Cerebral Cortical Lipid Peroxidation and Abnormal Phospholipids in Aged Homozygous apoE-Deficient C57BL/6J Mice (1999) (39)
- Uncommon morphologic features in subacute sclerosing panencephalitis (SSPE). Report of two cases with virus recovery from one autopsy brain specimen. (1970) (38)
- Carbon disulfide. (2000) (38)
- Inhibition of DNA polymerase from L1210 murine leukemia by a sulfhydryl reagent from agaricus bisporus. (1977) (37)
- Endogenous catechol thioethers may be pro-oxidant or antioxidant. (1999) (34)
- Carbon disulfide mediated protein cross-linking by N,N-diethyldithiocarbamate. (1995) (34)
- In vitro and in vivo studies of the molecular pathogenesis of n-Hexane neuropathy. (1982) (33)
- Characterization of Carbon Disulfide Neurotoxicity in C57BL6 Mice: Behavioral, Morphologic, and Molecular Effects (2000) (33)
- Covalent crosslinking of neurofilaments in the pathogenesis of n-hexane neuropathy. (1985) (32)
- Enhancement of Dopaminergic Neurotoxicity by the Mercapturate of Dopamine (2000) (31)
- Delayed neurotoxicity from long-term low-level topical administration of leptophos to the comb of hens. (1978) (31)
- Neurotoxicants and the cytoskeleton. (1999) (29)
- CS2-mediated cross-linking of erythrocyte spectrin and neurofilament protein: dose response and temporal relationship to the formation of axonal swellings. (1997) (29)
- High-pressure liquid chromatography quantitation of cytochrome c using 393 nm detection. (1999) (29)
- Carbon disulfide neurotoxicity in rats: V. Morphology of axonal swelling in the muscular branch of the posterior tibial nerve and spinal cord. (1998) (28)
- Intermediates in the Paal-Knorr synthesis of pyrroles. 4-Oxoaldehydes. (1995) (28)
- The metabolic pathway catalyzed by the tyrosinase of Agaricus bisporus. (1980) (27)
- In vitro acrylamide exposure alters growth cone morphology. (1995) (27)
- The effect of acrylamide and other sulfhydryl alkylators on the ability of dynein and kinesin to translocate microtubules in vitro. (1995) (26)
- Delayed neurotoxicity of leptophos and related compounds: differential effects of subchronic oral administration of pure, technical grade and degradation products on the hen. (1980) (26)
- The role of the environment in Parkinson's disease. (1996) (26)
- The mechanism of nucleophilic substitution of alkylpyrroles in the presence of oxygen. (1994) (26)
- Delayed neurotoxic, late acute and cholinergic effects of S,S,S-tributyl phosphorotrithioate (DEF): subchronic (90 days) administration in hens. (1979) (26)
- Covalent cross-linking of proteins by carbon disulfide. (1992) (25)
- Synthesis of gamma-L-glutaminyl-[3,5-3H]4-hydroxybenzene and the study of reactions catalyzed by the tyrosinase of Agaricus bisporus. (1979) (25)
- Environmental neurotoxic illness: research for prevention. (1994) (25)
- Intracellular activation of gamma-L-glutaminyl-4-hydroxybenzene by tyrosinase, a mechanism for selective cytotoxicity against melanocarcinoma. (1979) (24)
- Covalent cross-linking of erythrocyte spectrin by carbon disulfide in vivo. (1993) (24)
- Differential metabolism of O-ethyl O-4-nitrophenyl phenylphosphonothioate by rat and chicken hepatic microsomes. (1982) (24)
- Delayed neurotoxicity of O-ethyl O-2,4-dichlorophenyl phenylphosphonothioate: effects of a single oral dose on hens. (1979) (24)
- Melanocytotoxicity and the Mechanism of Activation of γ-L-Glutaminyl-4-hydroxybenzene (1980) (23)
- Cytostatic, cytocidal and potential antitumor properties of a class of quinoid compounds, initiators of the dormant state in the spores of Agaricus bisporus. (1975) (23)
- The Role of Pyrrole Formation in the Alteration of Neurofilament Transport Induced during Exposure to 2,5-Hexanedione (1992) (22)
- Stereoisomer Effects on the Paal-Knorr Synthesis of Pyrroles. (1986) (22)
- Bacteriocidal properties of a class of quinoid compounds related to sporulation in the mushroom, Agaricus bisporus. (1974) (22)
- dl- versus meso-3,4-dimethyl-2,5-hexanedione: a morphometric study of the proximo-distal distribution of axonal swellings in the anterior root of the rat. (1987) (20)
- Secondary excitotoxicity contributes to dopamine-induced apoptosis of dopaminergic neuronal cultures. (1998) (20)
- Comparison of Location, Severity, and Dose Response of Proximal Axonal Lesions Induced by 3,3′‐lminodipropionitrile and Deuterium Substituted Analogs (1992) (20)
- Heinz body production and hematological changes in the hen after administration of a single oral dose of n-butyl mercaptan and n-butyl disulfide. (1983) (20)
- Electromyographic, neuropathologic, and functional correlates in the cat as the result of tri-o-cresyl phosphate delayed neurotoxicity. (1986) (20)
- Exposure of C57BL/6 mice to carbon disulfide induces early lesions of atherosclerosis and enhances arterial fatty deposits induced by a high fat diet. (1999) (20)
- Covalent modification of hemoglobin by carbon disulfide: III. A potential biomarker of effect. (1998) (19)
- Metabolism of 3,3'-iminodipropionitrile and deuterium-substituted analogs: potential mechanisms of detoxification and activation. (1994) (18)
- Congenital giant axonal neuropathy. (1985) (17)
- Fibroblasts that express aromatic amino acid decarboxylase have increased sensitivity to the synergistic cytotoxicity of L-dopa and manganese. (1994) (17)
- Characterization of protein adducts produced by N-methyldithiocarbamate and N-methyldithiocarbamate esters. (1995) (16)
- Delayed neurotoxicity induced by organophosphorus compounds in the wild mallard duckling: effect of leptophos. (1978) (16)
- Thirteen-week toxicity study of n-hexane in B6C3F1 mice after inhalation exposure. (1989) (15)
- Identification of a new urinary metabolite of carbon disulfide using an improved method for the determination of 2-thioxothiazolidine-4-carboxylic acid. (2001) (15)
- Investigation of structure-function relationships of cytotoxic quinones of natural and synthetic origin. (1978) (15)
- The molecular mechanism of the carbon disulfide mediated cross-linking of proteins. (1991) (14)
- Delayed neurotoxicity of subchronic oral administration of leptophos to hens: recovery during four months after exposure. (1979) (14)
- Hamster hepatic nuclear mixed-function amine oxidase: location and specific activity. (1980) (13)
- Carbon disulfide and N,N-diethyldithiocarbamate generate thiourea cross-links on erythrocyte spectrin in vivo. (1998) (12)
- Coumaphos: delayed neurotoxic effect following dermal administration in hens. (1982) (12)
- Dialkyldithiocarbamates inhibit tyrosine hydroxylase activity in PC12 cells and in fibroblasts that express tyrosine hydroxylase. (1995) (12)
- Strategies for the prevention of environmental neurotoxic illness. (1993) (12)
- A 13-week vapor inhalation study of n-hexane in rats with emphasis on neurotoxic effects. (1984) (11)
- Neurotoxicity of continuous (90 days) inhalation of technical grade methyl butyl ketone in hens. (1982) (11)
- Evidence that pyrrole formation is a pathogenetic step in gamma-diketone neuropathy. (1987) (11)
- Decreased levels of the high molecular weight subunit of neurofilaments and accelerated neurofilament transport during the recovery phase of 2,5-hexanedione exposure. (1993) (10)
- Carbon disulfide neurotoxicity in rats: VIII. Summary. (1998) (10)
- Late acute, delayed neurotoxic and cholinergic effects of S,S,S-tributyl phosphorotrithioite (Merphos) in hens. (1980) (10)
- DOPAMINE MERCAPTURATE CAN AUGMENT DOPAMINERGIC NEURODEGENERATION* (2000) (10)
- Molecular Mechanisms of y-Diketone Neuropathy (1991) (10)
- OXIDATIVE PATHWAYS FOR CATECHOLAMINES IN THE GENESIS OF NEUROMELANIN, CYTOTOXIC QUINONES AND SUPEROXIDE (O2) AND HYDROXIDE (OH.) RADICALS (1978) (10)
- Aliphatic diketones: influence of dicarbonyl spacing on amine reactivity and toxicity. (1988) (9)
- Hyperbaric oxygen accelerates the neurotoxicity of 2,5-hexanedione. (1987) (9)
- The role of gamma-glutamyl transpeptidase in the nephrotoxicity of an Agaricus bisporus metabolite. (1980) (9)
- THE NEUROFILAMENT NEUROPATHIES: A UNIFYING HYPOTHESIS (1982) (9)
- Neurofilament protein crosslinking in gamma-diketone neuropathy: in vitro and in vivo studies using the seaworm myxicola infundibulum. (1989) (8)
- The neurotoxicity of 5-nonanone: preliminary report. (1981) (8)
- Sensitivity of the cat to delayed neurotoxicity induced by O-ethyl O-4-nitrophenyl phenylphosphonothioate. (1983) (8)
- Effect of subchronic dermal application of O-ethyl O-4-nitrophenyl phenylphosphonothioate on producing delayed neurotoxicity in hens. (1983) (8)
- Oxidative Stress and Parkinson Disease (2011) (8)
- A seasonal eosinophilic dermatitis in cats. (1992) (5)
- Membrane flow within the myelin sheath in IDPN neuropathy (1991) (5)
- Hemorrhagic cerebral white matter: infarction with cerebral deep venous thrombosis and hypoxia. (1978) (4)
- Pathogenetic Studies of the Neurofilamentous Neuropathies (1986) (3)
- Concerning the role of mitochondria in cryptobiosis. (1975) (3)
- 37 STABLE PROTEINS AS TARGETS IN DIKETONE NEUROPATHY (1984) (3)
- Endogenous Brain Catechol Thioethers in Dopaminergic Neurodegeneration (2000) (3)
- Protein crosslinking correlates with axonal atrophy, swelling and degeneration in gamma-diketone neuropathy: commentary on forum position paper. (1997) (3)
- Molecular mechanisms of gamma-diketone neuropathy. (1991) (2)
- Cross-species extrapolation in hydrocarbon neuropathy. (1984) (2)
- Comment on the commonality of manganese neurotoxicity and Parkinson's disease. (1981) (2)
- Infections of the human central nervous system by myxovirus-paramyxovirus following the attenuated measles virus vaccine. (1971) (2)
- AN HYPOTHESIS FOR THE MOLECULAR PATHOGENESIS OF HEXANE NEUROPATHY (1980) (2)
- EVIDENCE THAT IDPN MAY BE ACTIVATED BY PQQ-CONTAINING AMINE OXIDASES: 142 (1989) (2)
- Critical analysis of Mitran et al. (1997). Neurotoxicity associated with occupational exposure to acetone. Methyl ethyl ketone, and cyclohexanone. Environ. Res. 73, 181-188. (2000) (2)
- Melanocytotoxicity and the mechanism of activation of gamma-L-glutaminyl-4-hydroxybenzene. (1980) (1)
- Electron microscopic and biochemical studies of late-onset Pompe's disease (Cori type II b glycogeneosis): proposal for pathogenesis, potential for therapy. (1971) (1)
- Commentary on 'Toxicity of Aminochromes'. (1989) (1)
- Fundamental Neuropathology for Pathologists and Toxicologists: An Introduction (2011) (1)
- Dimethylhexanedione impairs the movement of neurofilament protein subunits, NFM and NFL, in the optic system. (1994) (1)
- THE EFFECTS OF 2,5-HEXANEDIONE AND 3-ACETYL-2,5-HEXANEDIONE ON NEUROFILAMENT TRANSPORT: 100 (1990) (0)
- OXIDATIVE DAMAGE TO CYTOPLASMIC DNA AND RNA IN SUBSTANTIA NIGRA NEURONS OF PATIENTS WITH PARKINSONʼS DISEASE (1999) (0)
- Strategies for the Prevention of Environmental Neurotoxic Illness1 (1994) (0)
- STUDIES ON THE MOLECULAR MECHANISM OF NEUROFILAMENT AGGREGATION IN CARBON DISULFIDE AXONOPATHY: 165 (1990) (0)
- 83 OPIOID RECEPTORS IN HIPPOCAMPAL FORMATION IN THE KINDLING MODEL OF TEMPORAL LOBE EPILEPSY (1983) (0)
- Appendixes: Ready References of Neurobiology Knowledge (2011) (0)
- 5-S-CYSTEINYL-3,4-DIHYDROXYPHENYLACETATE IS INDIRECTLY EXCITOTOXIC (1997) (0)
- FOR PATHOLOGISTS AND TOXICOLOGISTS: AN INTRODUCTION (2011) (0)
- Carbon disulfide (multiple letters) (2000) (0)
- 83 CONGENITAL GIANT AXONAL NEUROPATHY (1984) (0)
- THE CLINICAL SIGNIFICANCE OF INFLAMMATION WITHOUT ARTERITIS IN TEMPORAL ARTERY BIOPSIES: 208 (1995) (0)
- MELANIN ACCUMULATION AND CYTOTOXICITY IN ORGANOTYPIC HIPPOCAMPAL NEURONS EXPOSED TO A LIPOPHILIC ANALOG OF DOPAMINE (1996) (0)
- Science funding. The National Advisory Environmental Health Sciences Council. (1995) (0)
- IN VIVO AND IN VITRO DEGENERATION OF THE SYMPATHETIC NERVOUS SYSTEM IN ORGANOPHOSPHORUS-INDUCED DELAYED NEUROTOXICITY (1980) (0)
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