Derek G. Smyth

Derek G. Smyth's AcademicInfluence.com Rankings

Derek G. Smyth

Chemistry

#3264

World Rank

#4267

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Organic Chemistry

#517

World Rank

#597

Historical Rank

chemistry Degrees

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Chemistry

Derek G. Smyth's Degrees

PhD Chemistry University of California, Berkeley
Bachelors Chemistry University of California, Berkeley

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Derek G. Smyth's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Mechanism of C-terminal amide formation by pituitary enzymes (1982) (557)
C fragment of lipotropin has a high affinity for brain opiate receptors (1976) (467)
The sequence of amino acid residues in bovine pancreatic ribonuclease: revisions and confirmations. (1963) (408)
Reactions of N-ethylmaleimide with peptides and amino acids. (1964) (312)
The use of cyanate for the determination of NH2-terminal residues in proteins. (1963) (291)
Endorphins are stored in biologically active and inactive forms: isolation of α-N-acetyl peptides (1979) (243)
Some Reactions of N-Ethylmaleimide1 (1960) (230)
β-Endorphin is processed differently in specific regions of rat pituitary and brain (1982) (162)
Distribution of active and inactive forms of endorphins in rat pituitary and brain. (1979) (160)
Biosynthetic origin and receptor conformation of methionine enkephalin (1976) (155)
The determination of glucosamine and galactosamine. (1970) (154)
Lipotropin: precursor to two biologically active peptides. (1976) (146)
Influence of N-terminal acetylation and C-terminal proteolysis on the analgesic activity of beta-endorphin. (1980) (140)
Induction of excessive grooming in the rat by fragments of lipotropin (1976) (140)
Vasopressin coexists in half of the corticotropin-releasing factor axons present in the external zone of the median eminence in normal rats. (1987) (128)
Distribution of beta-endorphin-related peptides in rat pituitary and brain. (1982) (126)
[24] Techniques in enzymic hydrolysis (1967) (123)
Dependence creating properties of lipotropin C-fragment (beta-endorphin): evidence for its internal control of behavior. (1979) (105)
Selective processing of β-endorphin in regions of porcine pituitary (1980) (103)
Induction of tolerance to the analgesic action of lipotropin C-Fragment (1976) (102)
C‐FRAGMENT OF LIPOTROPIN—AN ENDOGENOUS POTENT ANALGESIC PEPTIDE (1977) (101)
Peptide amidation. (1991) (98)
On the sequence of residues 11 to 18 in bovine pancreatic ribonuclease. (1962) (92)
beta-Endorphin and related peptides in pituitary, brain, pancreas and antrum. (1983) (84)
γ Endorphin, α endorphin and Met-enkephalin are formed extracellularly from lipotropin C fragment (1977) (81)
A new glycopeptide in pig, ox and sheep pituitary. (1979) (80)
Biosynthesis of the C-terminal amide in peptide hormones (1987) (80)
Endopeptidases and prohormone processing (1990) (76)
A novel peptide, pyroglutamylglutamylproline amide, in the rabbit prostate complex, structurally related to thyrotrophin-releasing hormone. (1989) (74)
The glycopeptide moiety of vasopressin-neurophysin precursor is neurohypophysial prolactin releasing factor. (1988) (69)
Substrate specificity of an amidating enzyme in porcine pituitary. (1983) (65)
Proinsulin: a proposed three-dimensional structure. (1975) (60)
Comparison of the analgesic properties of lipotropin C-fragment and stabilized enkephalins in the rat. (1977) (57)
Acetylation of amino and tyrosine hydroxyl groups. Preparation of inhibitors of oxytocin with no intrinsic activity on the isolated uterus. (1967) (53)
Isolation and identification of two neutral thyrotropin releasing hormone-like peptides, pyroglutamylphenylalanineproline amide and pyroglutamylglutamineproline amide, from human seminal fluid. (1992) (52)
Glycyl glutamine, an inhibitory neuropeptide derived from β-endorphin (1983) (50)
Immunocytochemical localization of ß-endorphin (lipotropin c-fragment) in the developing rat spinal cord and hypothalamus (1982) (47)
4-Phenyl-3-butenoic acid, an in vivo inhibitor of peptidylglycine hydroxylase (peptide amidating enzyme). (1990) (46)
Isolation of the C-fragment and C'-fragment of lipotropin from pig pituitary and C-fragment from brain. (1978) (46)
The NH2-terminus of C-fragment is resistant to the action of aminopeptidases. (1977) (45)
Enzyme‐catalysed peptide amidation (1987) (45)
The amidating enzyme in pituitary will accept a peptide with C-terminal D-alanine as substrate. (1983) (43)
The oligosaccharide units of rabbit immunoglobulin G. Multiple carbohydrate attachment sites. (1972) (43)
Evidence for the Neurotrophic Regulation of Collagen‐Tailed Acetylcholinesterase in Immature Skeletal Muscle by β‐Endorphin (1984) (42)
Analgesic activity of lipotropin C fragment depends on carboxyl terminal tetrapeptide (1977) (40)
Specific cleavage of lipotropin C-fragment by endopeptidases; evidence for a preferred conformation. (1977) (37)
The amino acid sequence of the C-peptide of human proinsulin. (1971) (37)
Catalysis of Slow C‐Terminal Processing Reactions by Carboxypeptidase H (1989) (35)
The TRH‐related peptide pyroglutamylglutamylprolinamide is present in human semen (1989) (35)
Distribution of pyroglutamylpeptide amides related to thyrotrophin-releasing hormone in the central nervous system and periphery of the rat. (1990) (32)
The thyrotrophin-releasing hormone (TRH)-like peptides in rat prostate are not formed by expression of the TRH gene but are suppressed by thyroid hormone. (1992) (29)
The oligosaccharide units of rabbit immunoglobulin G. Asymmetric attachment of C2-oligosaccharide. (1972) (29)
The C-fragment of lipotropin - a potent analgesic [proceedings]. (1976) (28)
Specific processing of the thyrotropin-releasing prohormone in rat brain and spinal cord. (1987) (28)
The use of 3-bromopropionic acid for the determination of protein thiol groups. (1973) (27)
Unequivocal assignments of NH proton magnetic resonance bands in oxytocin using 2H‐ and 15N‐substituted molecules (1974) (26)
60 YEARS OF POMC: Lipotropin and beta-endorphin: a perspective. (2016) (24)
β-Endorphin processing in pituitary and brain is sensitive to haloperidol stimulation (1985) (24)
β‐Endorphin and ACTH related peptides in primary cultures of rat anterior pituitary cells: evidence for different intracellular pools (1985) (24)
Chromatography of peptides related to β-endorphin (1984) (23)
Regulation of bioactive β‐endorphin processing in rat pars intermedia (1984) (23)
Susceptibility of neuroactive peptides to aminopeptidase digestion is related to molecular size. (1979) (22)
The processing of β-endorphin and α-melanotrophin in the pars intermedia of Xenopus laevis is influenced by background adaptation (1992) (22)
Metabolism of the analgesic peptide lipotropin C‐Fragment in rat striatal slices (1977) (21)
The peptide hormones: molecular and cellular aspects (1975) (20)
Continuous infusion of propofol in dystrophia myotonica (1989) (19)
The synthesis of tritiovaline and its incorporation into rat-visceral proteins. (1958) (19)
Purification of a cysteine endopeptidase which is secreted with bioactive peptides from the epidermal glands of Xenopus laevis. (1991) (18)
Some analytical problems involved in determining the structure of proteins and peptides. A review (1964) (18)
Lipotropin C-fragment has a COOH-terminal sequence with high intrinsic resistance to the action of exopeptidases. (1977) (18)
Carbamylation of amino and tyrosine hydroxyl groups. Preparation of an inhibitor of oxytocin with no intrinsic activity on the isolated uterus. (1967) (18)
Prohormones of beta-melanotropin (beta-melanocyte-stimulating hormone, beta-MSH) and corticotropin (adrenocorticotropic hormone, ACTH): structure and activation. (1976) (18)
Processing of the thyrotropin releasing hormone (TRH) precursor in Xenopus skin and bovine hypothalamus: evidence for the existence of extended forms of TRH (1986) (17)
Thyrotrophin-releasing hormone-related polypeptides in rabbit prostate and semen are different from those in rabbit hypothalamus. (1989) (17)
Chronic stimulation of anterior pituitary cell cultures with CRF leads to the secretion of lipotropin. (1986) (16)
Hallucinations after propofol (1988) (16)
α, N-acetyl derivatives of β-endorphin in rat pituitary: Chromatographic evidence for processed forms of β-endorphin in pancreas and brain (1982) (16)
The TRH‐like peptides in rabbit testis are different from the TRH‐like peptide in the prostate (1996) (15)
Endorphins are stored in biologically active and inactive forms: isolation of alpha-N-acetyl peptides. (1979) (15)
Proton magnetic resonance studies on [methionine]-enkephalin and beta-endorphin in aqueous solution. (1979) (14)
Bovine proinsulin: amino acid sequence of the C-peptide isolated from pancreas. (1971) (14)
The thyrotropin-releasing hormone-like peptides pGlu-Phe-Pro amide and pGlu-Glu-Pro amide increase plasma triiodothyronine levels in the mouse; the activity is sensitive to testosterone. (1998) (13)
Preparation and characterisation of a specific antiserum to the C‐Fragment of lipotropin (1977) (12)
Beta-endorphin is present in active and inactive forms in rat gastric antrum. (1986) (12)
Some techniques in the assay of tritium. (1956) (12)
Selective processing of beta-endorphin in regions of porcine pituitary. (1980) (12)
Studies on the asymmetrically attached oligosaccharide of rabbit immunoglobulin-G. I. Biosynthesis and stability of the C2-oligosaccharide. (1970) (12)
Preparation of human C-peptide. (1971) (12)
Substrate recognition by UDP-N-acetyl-α-d-galactosamine: polypeptide N-acetyl-α-d-galactosaminyltransferase. Effects of chain length and disulphide bonding of synthetic peptide substrates (1988) (12)
Analgesia produced in cats by the C-fragment of lipotropin and by a synthetic pentapeptide [proceedings]. (1977) (11)
The C-terminal dipeptide of β-endorphin: A neuropeptide with inhibitory activity (1983) (11)
Antigenicity of the β-Chain of Human Hæmoglobin (1964) (11)
Sequential formation of beta-endorphin-related peptides in porcine pituitary. (1988) (11)
Isolation and identification of N-terminally extended forms of 5-oxoprolylglutamylprolinamide (Glp-Glu-Pro-NH2), a thyrotropin-releasing-hormone (TRH)-like peptide present in human semen. (1993) (11)
Peptide amidation: evidence for multiple molecular forms of the amidating enzyme. (1988) (10)
Beta-endorphin-related peptides in the pituitary gland: isolation, identification and distribution. (1981) (10)
Glycyl glutamine, an inhibitory neuropeptide derived from beta-endorphin. (1983) (10)
Studies on the Bohr Effect of Sheep Hemoglobin (1961) (10)
Studies on the asymmetrically attached oligosaccharide of rabbit immunoglobulin-G. II. On the biological function of the C2-oligosaccharide. (1970) (10)
Characterization of neutral TRH-like peptides in mammary gland, mammary tumors and milk. (2000) (10)
Carbamylation of Oxytocin and Arginine-Vasopressin (1963) (9)
Detection of TRH extended peptides in rat hypothalamus using an antibody raised to pGluHisProGlyLys (1986) (9)
Use of 125I-Tyr27 β-Endorphin for the Study of β-Endorphin Binding Sites in Rat Cortex (1986) (9)
Influence of dopaminergic agents on beta-endorphin processing in rat pars intermedia. (1984) (9)
Characterization of a proteolytic enzyme in the skin secretions of Xenopus laevis. (1988) (9)
Guinea pig proinsulin. Primary structure of the C-peptide isolated from pancreas. (1975) (8)
Isolation of beta-endorphin-related peptides from ox pituitary. (1980) (8)
Identification of the TRH-like peptides pGlu–Glu–Pro amide and pGlu–Phe–Pro amide in rat thyroid: regulation by thyroid status (1999) (8)
ISOLATION AND IDENTIFICATION OF TWO NEW PEPTIDES RELATED TO β-ENDORPHIN (1981) (8)
Molecular cloning in the marmoset shows that semenogelin is not the precursor of the TRH-like peptide pGlu-Glu-Pro amide. (1998) (8)
Proteolysis of Lipotropin C-Fragment Takes Place Extracellularly to Form γ-Endorphin and [Methionine]Enkephalin (1977) (7)
Synthesis and high-performance liquid chromatographic purification of tritiated thyrotrophin-releasing hormone-like peptides. (1994) (7)
Sequential processing reactions in the formation of hormone amides. (1987) (7)
Studies on limited proteolysis and degradation of lipotropin C-fragment [proceedings]. (1977) (7)
Exaggerated physiological responses to propofol in myotonic dystrophy. (1990) (7)
Pyroglutamylpeptide amides in rat central nervous system: possible new class of neurotransmitter. (1990) (6)
The effect of acylation on the molecular size of insulin. (1972) (6)
β-Endorphin in Brain (1982) (6)
Effects of vasopressin-glycine and vasopressin-glycine-lysine-arginine on renal function in the rat. (1986) (6)
Biogenesis and metabolism of opiate active peptides (1978) (5)
Enzyme-catalysed peptide amidation. Isolation of a stable intermediate formed by reaction of the amidating enzyme with an imino acid. (1987) (5)
Isolation and characterization of endogenous [α]-n-acyl derivatives of the C and C′ of lph (1979) (5)
gamma endorphin, alpha endorphin and Met-enkephalin are formed extracellularly from lipotropin C fragment. (1977) (5)
Quantitative blocking of amino groups in acid solution by carbamylation (1966) (5)
The amino acid sequence of guinea pig C-peptide (1974) (5)
On the molecular mechanism of oxytocin action. (1970) (5)
β-endrophin: modulation of acute tolerance and antagonism by endogenous brain systems (1978) (5)
Isolation of glycylglutamine, the C-terminal dipeptide of the β-endorphin corticotropin prohormone (1982) (4)
Conformational properties of the opiate peptide C-fragment, and related peptides from lipotropin [proceedings]. (1977) (4)
Processing reactions in the later stages of hormone activation. (1988) (4)
PRIMARY STRUCTURE AND SPECIFICITY IN ENDOGENOUS OPIOID PEPTIDES (1980) (4)
Synthesis of tritium labelled TRH-like peptides using asymmetric anhydride coupling (1991) (3)
The common prohormone of corticotropin and the opiate peptide lipotropin C-fragment (beta-endorphin). (1978) (3)
Acylation reactions with cyclic imides. (1968) (3)
Lipotropin and beta-endorphin : a perspective (2016) (3)
Constructing semisynthetic polypeptides (1975) (3)
The C-terminal dipeptide of beta-endorphin: a neuropeptide with inhibitory activity. (1983) (3)
Olefinic additions with asymmetric reactants. Part III. The resolution and addition reactions of 3-ethylhept-3-en-2-ol. A partial asymmetric synthesis effected by hydrogenation (1955) (3)
Chromatography of peptides related to beta-endorphin. (1984) (3)
Molecular Changes in Exchange Labelling with Tritium (1958) (3)
beta-Endorphin: modulation of acute tolerance and antagonism by endogenous brain systems. (1978) (3)
β-ENDORPHIN IN THE BRAIN AND PITUITARY; EVIDENCE FOR TWO SPECIFIC PROCESSING PATTERNS (1981) (3)
Preparation and properties of lipotropin C‐Fragment with anionic substituents attached to the lysine residues (1977) (3)
beta-Endorphin in brain. (1982) (3)
Fluorescent inhibitors of peptidylglycine hydroxylase (1991) (2)
Amidation of Synthetic Peptides by Pituitary Enzyme: Specificity and Mechanism of the Reaction (1983) (2)
The processing of beta-endorphin and alpha-melanotrophin in the pars intermedia of Xenopus laevis is influenced by background adaptation. (1992) (2)
Use of 125I-Tyr27 beta-endorphin for the study of beta-endorphin binding sites in rat cortex. (1986) (2)
alpha, N-acetyl derivatives of beta-endorphin in rat pituitary: chromatographic evidence for processed forms of beta-endorphin in pancreas and brain. (1982) (2)
[47] Use of papain, pepsin, and subtilisin in sequence determination (1967) (2)
Biologically active macromolecular forms of oxytocin. [8-Lysine]oxytocin as a suitable ligand. (1977) (2)
Interactions of peptides derived from the C-fragment of beta-lipotropin with brain opiate receptors [proceedings]. (1976) (2)
Regulation of bioactive beta-endorphin processing in rat pars intermedia. (1984) (2)
ANTIGENICITY OF THE BETA-CHAIN OF HUMAN HAEMOGLOBIN. (1964) (1)
Methods used in the study of TRH-like peptides in rat prostate. (1991) (1)
C‐Terminally Extended Forms of Thyrotropin‐Releasing Hormone (TRH) in Rat Brain and Spinal Cord (1989) (1)
Effects of C-fragment on brain stem neurones in the cat [proceedings]. (1977) (1)
Protirelin (thyrotropin-releasing hormone) in thyroid gland: possible involvement in regulation of thyroid status. (1999) (1)
MECHANISMS FOR ACTIVATION AND INACTIVATION OF ENDORPHINS (1981) (1)
The quest for a latent action insulin. (1973) (1)
[125I] Tyr27 β-endorphin: A radio-iodinated derivative of β-endorphin for the study of opiate receptors (1984) (1)
CHEMICAL REACTIONS OF N-ETHYLMALEIMIDE (1966) (1)
Contents (2010) (0)
Subject Index Vol. 43, 1986 (1986) (0)
A study of the substrate specificity of carboxypeptidase H (1988) (0)
Differential Regulation of ACTH and β-Endorphin by Controlled Processing (1986) (0)
SPECIFIC PROCESSING OF ENDORPHINS IN RAT BRAIN (1980) (0)
Extended Peptides in Rat an Antibody Raised to (2005) (0)
Inhibitory actions of diketopiperazines within the thyroid gland, and their system-wide presence (2019) (0)
Biosynthesis of peptide neurotransmitters: studies on the formation of peptide amides. (1988) (0)
Selective processing of the 31000-molecular-weight adrenocorticotropin prohormone of endorphin: activation and inactivation mechanisms (1980) (0)
Resolution of 3 ethylhept 3 En 2 Ol and the stereochemistry of some addition reactions with the (2)-, (-)-, and (+)- alcohols (1954) (0)
Detection of TRH Hypothalamus Using pGluHis ProGlyLys (1986) (0)
The biosynthesis of a tritium-labelled antibody. (1958) (0)
Biosynthesis and Targeting of β-Endorphin (1986) (0)
Proteolysis of lipotropin C-fragment takes place extracellularly to form gamma-endorphin and [methionine]enkephalin [proceedings]. (1977) (0)
Stanford Moore 1913–1982 (1983) (0)
The relationship between the structure and biological activity of some peptides and proteins (excluding enzymes) (1969) (0)
[125I] Tyr27 beta-endorphin: a radio-iodinated derivative of beta-endorphin for the study of opiate receptors. (1984) (0)
The Importance of Defined Tracers in RIA (1986) (0)
PREPARATION OF SUBSTRATE INHIBITORS OF THE AMIDATING ENZYME IN PORCINE PITUITARY (1987) (0)
Exaggerates physiological responses to propofol in myotonic dystrophy. Author's reply (1990) (0)
Effects ofC-fragment onbrain stem neurones inthecat (1977) (0)
Chemical modifications of proteins : by A. N. Glazer, R. J. Delange and D. S. Sigman North-Holland Publishing Company; Amsterdam, New York, 1975 iv + 205 pages. Dfl. 28.00, $ 11.75 (paper) (1977) (0)
Regulation of processing in multi-functional prohormones: a new hypothesis. (1985) (0)
Prohormone processing reactions: discrete stages in the formation of beta-endorphin related peptides. (1986) (0)
Substrate recognition by UDP-N-acetyl-alpha-D-galactosamine: polypeptide n-acetyl-alpha-D-galactosaminyltransferase. Effects of chain length and disulphide bonding of synthetic peptide substrates. (1988) (0)
The use of cyanate for the determination of NH 2 -terminal residues in N-acylated proteins. (1973) (0)
Processing of thyrotropin-releasing-hormone-related peptides in rabbit hypothalamus and prostate (1988) (0)
Subject Index Vol. 44, 1986 (1986) (0)
Radiolabelling in studies of peptide hormones (1988) (0)

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What Schools Are Affiliated With Derek G. Smyth?

Derek G. Smyth is affiliated with the following schools:

Yale University