David J. Prof Baylink

David J. Prof Baylink's AcademicInfluence.com Rankings

Biology

#4347

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#6491

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Biochemistry

#442

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#522

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Biology

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David J. Prof Baylink's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions. (1997) (1116)
Genetic variability in adult bone density among inbred strains of mice. (1996) (623)
Fluoride directly stimulates proliferation and alkaline phosphatase activity of bone-forming cells. (1983) (580)
Inhibition of bone formation during space flight. (1978) (482)
IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms. (2002) (455)
Castrated men exhibit bone loss: effect of calcitonin treatment on biochemical indices of bone remodeling. (1989) (427)
Growth factors for bone growth and repair: IGF, TGFβ and BMP (1996) (416)
Growth factors to stimulate bone formation (1993) (398)
Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice. (2000) (391)
Androgens directly stimulate proliferation of bone cells in vitro. (1989) (389)
Bone growth factors. (1991) (379)
Effects of short term administration of recombinant human growth hormone to elderly people. (1990) (375)
Fluid flow shear stress stimulates human osteoblast proliferation and differentiation through multiple interacting and competing signal transduction pathways. (2003) (363)
Isolation of an inhibitory insulin-like growth factor (IGF) binding protein from bone cell-conditioned medium: a potential local regulator of IGF action. (1989) (357)
Glucocorticoid-induced osteoporosis. (1983) (330)
Studies on the Mechanisms by Which Insulin-like Growth Factor (IGF) Binding Protein-4 (IGFBP-4) and IGFBP-5 Modulate IGF Actions in Bone Cells (*) (1995) (309)
Parathyroid hormone stimulates bone formation and resorption in organ culture: evidence for a coupling mechanism. (1981) (247)
Radioligand receptor assay for 25-hydroxyvitamin D2/D3 and 1 alpha, 25-dihydroxyvitamin D2/D3. (1976) (234)
Human bone cells in culture metabolize 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3. (1981) (223)
Age-related decreases in insulin-like growth factor-I and transforming growth factor-beta in femoral cortical bone from both men and women: implications for bone loss with aging. (1994) (222)
Formation, mineralization, and resorption of bone in vitamin D-deficient rats. (1970) (222)
Quantitation of growth factors IGF‐I, SGF/IGF‐II, and TGF‐β in human dentin (1990) (218)
Phosphotyrosyl protein phosphatases. (1989) (217)
Inhibitory insulin-like growth factor-binding protein: cloning, complete sequence, and physiological regulation. (1990) (213)
Evidence that IGF-binding protein-5 functions as a growth factor. (2001) (211)
Quantitative Trait Loci for Femoral and Lumbar Vertebral Bone Mineral Density in C57BL/6J and C3H/HeJ Inbred Strains of Mice (2001) (207)
Decrease in serum immunoreactive parathyroid hormone in rats and in parathyroid hormone secretion in vitro by 1,25-dihydroxycholecalciferol. (1975) (203)
Genetic Regulation of Cortical and Trabecular Bone Strength and Microstructure in Inbred Strains of Mice (2000) (203)
The insulin-like growth factor system and the coupling of formation to resorption. (1995) (198)
Characterization and assay of tartrate-resistant acid phosphatase activity in serum: potential use to assess bone resorption. (1987) (194)
Generalized osteoarthritis associated with increased insulin-like growth factor types I and II and transforming growth factor beta in cortical bone from the iliac crest. Possible mechanism of increased bone density and protection against osteoporosis. (1993) (193)
Primary structure of human skeletal growth factor: homology with human insulin-like growth factor-II. (1988) (193)
Insulin-like growth factor regulates peak bone mineral density in mice by both growth hormone-dependent and -independent mechanisms. (2003) (185)
Formation, mineralization, and resorption of bone in hypophosphatemic rats. (1971) (182)
Increased serum 1,25-dihydroxyvitamin D in idiopathic hypercalciuria. (1977) (181)
Bayesian Shrinkage Estimation of Quantitative Trait Loci Parameters (2005) (177)
Growth factors for bone growth and repair: IGF, TGF beta and BMP. (1996) (175)
Up-regulation of the Wnt, Estrogen Receptor, Insulin-like Growth Factor-I, and Bone Morphogenetic Protein Pathways in C57BL/6J Osteoblasts as Opposed to C3H/HeJ Osteoblasts in Part Contributes to the Differential Anabolic Response to Fluid Shear* (2006) (174)
Skeletal growth factor and other growth factors known to be present in bone matrix stimulate proliferation and protein synthesis in human bone cells (1990) (174)
Studies of the mechanism by which androgens enhance mitogenesis and differentiation in bone cells. (1990) (172)
Circulating and skeletal insulin-like growth factor-I (IGF-I) concentrations in two inbred strains of mice with different bone mineral densities. (1997) (171)
Isolation of a novel insulin-like growth factor (IGF) binding protein from human bone: a potential candidate for fixing IGF-II in human bone. (1991) (168)
A new rat model simulating some aspects of space flight. (1979) (168)
Quantitative histological studies on the pathogenesis of uremic bone disease. (1974) (164)
Quantitative trait loci for bone density in C57BL/6J and CAST/EiJ inbred mice (1999) (162)
Exercise and Mechanical Loading Increase Periosteal Bone Formation and Whole Bone Strength in C57BL/6J Mice but Not in C3H/Hej Mice (2000) (161)
Evidence that anabolic effects of PTH on bone require IGF-I in growing mice. (2001) (157)
Estrogens in the prevention of osteoporosis in postmenopausal women. (1989) (154)
LOSS OF PROTEINPOLYSACCHARIDES AT SITES WHERE BONE MINERALIZATION IS INITIATED (1972) (152)
Effect of combined risedronate and hormone replacement therapies on bone mineral density in postmenopausal women. (2001) (148)
Characterization of Cells Isolated and Cultured from Human Bone (1984) (141)
Skeletal alkaline phosphatase activity as a bone formation index in vitro. (1986) (141)
Estradiol stimulates in vitro the secretion of insulin-like growth factors by the clonal osteoblastic cell line, UMR106. (1989) (139)
Microarray analysis of gene expression during the inflammation and endochondral bone formation stages of rat femur fracture repair. (2006) (136)
1,25-dihydroxycholecalciferol. Effect on skeletal lesions and plasma parathyroid hormone levels in uremic osteodystrophy. (1974) (135)
Evidence that human bone cells in culture produce insulin-like growth factor-binding protein-4 and -5 proteases. (1994) (135)
Low‐amplitude, low‐frequency electric field‐stimulated bone cell proliferation may in part be mediated by increased IGF‐II release (1992) (134)
Prevention of bone loss with tibolone in postmenopausal women: results of two randomized, double-blind, placebo-controlled, dose-finding studies. (2001) (130)
1,25-Dihydroxyvitamin D3 differentially regulates the production of insulin-like growth factor I (IGF-I) and IGF-binding protein-4 in mouse osteoblasts. (1991) (129)
Peripheral monocyte culture supernatants of menopausal women can induce bone resorption: involvement of cytokines. (1993) (129)
Insulin-like growth factors I and II are present in the skeletal tissues of ten vertebrates. (1990) (128)
Ovariectomy selectively reduces the concentration of transforming growth factor beta in rat bone: implications for estrogen deficiency-associated bone loss. (1992) (127)
Changes in markers of bone formation and resorption in a bed rest model of weightlessness (1993) (127)
Insulin-like Growth Factor-binding Protein 5 (IGFBP-5) Interacts with a Four and a Half LIM Protein 2 (FHL2)* (2002) (127)
Increased monocyte interleukin-1 activity and decreased vertebral bone density in patients with fasting idiopathic hypercalciuria. (1990) (126)
Development of a simple valid method for the complete removal of insulin-like growth factor (IGF)-binding proteins from IGFs in human serum and other biological fluids: comparison with acid-ethanol treatment and C18 Sep-Pak separation. (1995) (125)
A proposed mechanism of the mitogenic action of fluoride on bone cells: inhibition of the activity of an osteoblastic acid phosphatase. (1989) (125)
Purification of a skeletal growth factor from human bone. (1982) (121)
Molecular Mechanism of Action of Fluoride on Bone Cells (1998) (120)
Histomorphometric studies show that bone formation and bone mineral apposition rates are greater in C3H/HeJ (high-density) than C57BL/6J (low-density) mice during growth. (1999) (119)
Decreased bone formation, mineralization, and enhanced resorption in calcium-deficient rats. (1973) (119)
Combined magnetic fields increase insulin-like growth factor-II in TE-85 human osteosarcoma bone cell cultures. (1995) (115)
Human bone cell phenotypes differ depending on their skeletal site of origin. (1995) (114)
Conditional deletion of insulin-like growth factor-I in collagen type 1alpha2-expressing cells results in postnatal lethality and a dramatic reduction in bone accretion. (2007) (114)
Development of an immunoassay for human serum osteoclastic tartrate-resistant acid phosphatase. (1990) (113)
Down‐Regulation of the Serum Stimulatory Components of the Insulin‐like Growth Factor (IGF) System (IGF‐I, IGF‐II, IGF Binding Protein [BP]‐3, and IGFBP‐5) in Age‐Related (Type II) Femoral Neck Osteoporosis (1999) (113)
Effect of aging on stem cells (2017) (112)
Alkaline phosphatase levels and osteoprogenitor cell numbers suggest bone formation may contribute to peak bone density differences between two inbred strains of mice. (1998) (112)
Increases in number and size of osteoclasts in response to calcium or phosphorus deficiency in the rat. (1975) (112)
Growth hormone replacement therapy improves body composition and increases bone metabolism in elderly patients with pituitary disease. (2000) (112)
Development, validation, and application of a radioimmunoassay for insulin-like growth factor binding protein-5 in human serum and other biological fluids. (1995) (107)
Improved method for quantitative determination in serum of alkaline phosphatase of skeletal origin. (1981) (107)
Fluoride and bovine bone extract influence cell proliferation and phosphatase activities in human bone cell cultures. (1988) (107)
Effects of zinc and other nutritional factors on insulin-like growth factor I and insulin-like growth factor binding proteins in postmenopausal women. (1998) (107)
Postnatal and Pubertal Skeletal Changes Contribute Predominantly to the Differences in Peak Bone Density Between C3H/HeJ and C57BL/6J Mice (2001) (106)
Global gene expression analysis in the bones reveals involvement of several novel genes and pathways in mediating an anabolic response of mechanical loading in mice (2005) (105)
Cobalamin and osteoblast-specific proteins. (1988) (104)
Vitamin D deficiency causes a selective reduction in deposition of transforming growth factor beta in rat bone: possible mechanism for impaired osteoinduction. (1991) (102)
Pregnancy-associated plasma protein-A accounts for the insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) proteolytic activity in human pregnancy serum and enhances the mitogenic activity of IGF by degrading IGFBP-4 in vitro. (2001) (102)
Structure-Function Analysis of the Human Insulin-like Growth Factor Binding Protein-4* (1998) (102)
Ibandronate produces significant, similar antifracture efficacy in North American and European women: new clinical findings from BONE (2005) (102)
In vitro synthesis of 1 alpha,25-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol by isolated calvarial cells. (1980) (102)
Interactions of growth factors present in bone matrix with bone cells: effects on DNA synthesis and alkaline phosphatase. (1990) (102)
Genetic variation in femur extrinsic strength in 29 different inbred strains of mice is dependent on variations in femur cross-sectional geometry and bone density. (2005) (101)
Human Osteoblasts' Proliferative Responses to Strain and 17β‐Estradiol Are Mediated by the Estrogen Receptor and the Receptor for Insulin‐Like Growth Factor I (2002) (101)
The multi-functional role of insulin-like growth factor binding proteins in bone (2005) (101)
Quantitation of growth factors IGF-I, SGF/IGF-II, and TGF-beta in human dentin. (1990) (98)
DISTRIBUTION OF ACID AND ALKALINE PHOSPHATASE ACTIVITY IN UNDEMINERALIZED SECTIONS OF THE RAT TIBIAL DIAPHYSIS (1969) (98)
DEFICIENT CALCITONIN RESPONSE TO CALCIUM STIMULATION IN POSTMENOPAUSAL OSTEOPOROSIS? (1982) (97)
Cortical tibial bone volume in two strains of mice: effects of sciatic neurectomy and genetic regulation of bone response to mechanical loading. (1999) (96)
Systemic administration of insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) increases bone formation parameters in mice by increasing IGF bioavailability via an IGFBP-4 protease-dependent mechanism. (2001) (95)
Calcium and phosphorus deficiency in rats: effects on PTH and 1,25-dihydroxyvitamin D3. (1979) (93)
Comparison of bone formation responses to parathyroid hormone(1-34), (1-31), and (2-34) in mice. (2000) (93)
Patients with Van Buchem disease, an osteosclerotic genetic disease, have elevated bone formation markers, higher bone density, and greater derived polar moment of inertia than normal. (2003) (93)
Bone-resorption markers galactosyl hydroxylysine, pyridinium crosslinks, and hydroxyproline compared. (1992) (92)
Age-related changes in IGFBP-4 and IGFBP-5 levels in human serum and bone: implications for bone loss with aging. (1995) (91)
Disruption of insulin-like growth factor-I expression in type IIalphaI collagen-expressing cells reduces bone length and width in mice. (2007) (91)
Progesterone and promegestone stimulate human bone cell proliferation and insulin-like growth factor-2 production. (1992) (90)
Recombinant synthesis of insulin-like growth factor-binding protein-4 (IGFBP-4): Development, validation, and application of a radioimmunoassay for IGFBP-4 in human serum and other biological fluids. (1996) (90)
Clinical use of serum and urine bone markers in the management of osteoporosis (2005) (90)
Lack of a high prevalence of the BB vitamin D receptor genotype in severely osteoporotic women. (1995) (90)
Insulin-like growth factor system components and the coupling of bone formation to resorption. (1996) (90)
Insulin-like growth factor (IGF)-binding proteins in serum--do they have additional roles besides modulating the endocrine IGF actions? (1996) (90)
Disruption of the insulin-like growth factor-1 gene in osteocytes impairs developmental bone growth in mice. (2013) (89)
Studies on the potential mediators of skeletal changes occurring during puberty in girls. (1999) (88)
Effects of Spaceflight on Structural and Material Strength of Growing Bone (1983) (88)
Multiple osteocalcin fragments in human urine and serum as detected by a midmolecule osteocalcin radioimmunoassay. (1990) (87)
Nuclear Factor-E2-related Factor-1 Mediates Ascorbic Acid Induction of Osterix Expression via Interaction with Antioxidant-Responsive Element in Bone Cells* (2007) (87)
Bone formation by osteocytes. (1971) (87)
Pregnancy-associated plasma protein-A increases osteoblast proliferation in vitro and bone formation in vivo. (2006) (86)
In vivo bone formation in fracture repair induced by direct retroviral-based gene therapy with bone morphogenetic protein-4. (2003) (86)
Osteocyte-derived insulin-like growth factor I is essential for determining bone mechanosensitivity. (2013) (85)
Phosphotyrosyl-specific protein phosphatase activity of a bovine skeletal acid phosphatase isoenzyme. Comparison with the phosphotyrosyl protein phosphatase activity of skeletal alkaline phosphatase. (1985) (84)
Genetic control of the rate of wound healing in mice (2001) (84)
Biochemical markers of bone turnover for the clinical assessment of bone metabolism. (1994) (83)
Osteogenic protein-1 stimulates proliferation and differentiation of human bone cells in vitro. (1993) (83)
Development of valid methods to measure insulin-like growth factors-I and -II in bone cell-conditioned medium. (1990) (83)
Identification of wound healing/regeneration quantitative trait loci (QTL) at multiple time points that explain seventy percent of variance in (MRL/MpJ and SJL/J) mice F2 population. (2001) (83)
The effects of fluoride therapy on metabolic bone disease. A histologic study. (1967) (83)
Vitamin D Therapy of Osteoporosis: Plain Vitamin D Therapy Versus Active Vitamin D Analog (D-Hormone) Therapy (1999) (83)
The anti-bone-resorptive agent calcitonin also acts in vitro to directly increase bone formation and bone cell proliferation. (1988) (82)
IGF‐II receptor number is increased in TE‐85 osteosarcoma cells by combined magnetic fields (1995) (82)
Combined magnetic fields increased net calcium flux in bone cells (1994) (80)
The 24/25-kDa serum insulin-like growth factor-binding protein is increased in elderly women with hip and spine fractures. (1992) (79)
Insulin‐like Growth Factor (IGF)‐I, ‐II, IGF Binding Proteins (IGFBP)−3, −4, and −5 Levels in the Conditioned Media of Normal Human Bone Cells Are Skeletal Site‐Dependent (1997) (79)
Plasma prostaglandin E in patients with cancer with and without hypercalcemia. (1976) (79)
Insulin-like growth factor-binding protein-5 induces a gender-related decrease in bone mineral density in transgenic mice. (2005) (79)
Development of an MFG-based retroviral vector system for secretion of high levels of functionally active human BMP4. (2001) (78)
Vanadate stimulates bone cell proliferation and bone collagen synthesis in vitro. (1988) (78)
Electron microprobe measurements of bone mineralization rate in vivo. (1974) (77)
Fluoride therapy for osteoporosis: characterization of the skeletal response by serial measurements of serum alkaline phosphatase activity. (1987) (75)
Role of Osteocyte-derived Insulin-Like Growth Factor I in Developmental Growth, Modeling, Remodeling, and Regeneration of the Bone (2014) (75)
Evidence for the coupling of bone formation to bone resorption in vitro (1980) (75)
Elevated prostaglandins and suppressed parathyroid hormone associated with hypercalcemia and renal cell carcinoma. (1975) (73)
A Missense Mutation in the Mouse Col2a1 Gene Causes Spondyloepiphyseal Dysplasia Congenita, Hearing Loss, and Retinoschisis (2003) (73)
Analysis of gene expression in the wound repair/regeneration process (2001) (72)
ADAM-9 is an insulin-like growth factor binding protein-5 protease produced and secreted by human osteoblasts. (2002) (72)
Genetic dissection of femur breaking strength in a large population (MRL/MpJ x SJL/J) of F2 Mice: single QTL effects, epistasis, and pleiotropy. (2002) (72)
Purification and characterization of an acid phosphatase that displays phosphotyrosyl-protein phosphatase activity from bovine cortical bone matrix. (1987) (71)
Evidence that the interaction between insulin-like growth factor (IGF)-II and IGF binding protein (IGFBP)-4 is essential for the action of the IGF-II-dependent IGFBP-4 protease. (2000) (71)
Quantitative Trait Loci for Femoral and Lumbar Vertebral Bone Mineral Density in C57BL/6J and C3H/HeJ Inbred Strains of Mice (2001) (70)
In vitro evidence that bone formation may be coupled to resorption by release of mitogen(s) from resorbing bone. (1987) (70)
Evidence for a role for insulin-like growth factor binding proteins in glucocorticoid inhibition of normal human osteoblast-like cell proliferation. (1996) (70)
Effect of calcitonin on the rates of bone formation and resorption in the rat. (1969) (70)
Relationship between trabecular vertebral body density and fractures: a quantitative definition of spinal osteoporosis. (1988) (69)
Prevention and treatment of glucocorticoid-induced osteoporosis. A pathogenetic perspective. (1992) (69)
Quantitative Trait Loci for Bone Density in Mice: The Genes Determining Total Skeletal Density and Femur Density Show Little Overlap in F2 Mice (2002) (69)
Serum Levels of Insulin-Like Growth Factor (IGF); IGF-Binding Proteins-3, -4, and -5; and Their Relationships to Bone Mineral Density and the Risk of Vertebral Fractures in Postmenopausal Women (2006) (69)
Human skeletal alkaline phosphatase. Kinetic studies including pH dependence and inhibition by theophylline. (1980) (69)
Regulation of insulin-like growth factor system components by osteogenic protein-1 in human bone cells. (1995) (68)
Recombinant human insulin-like growth factor-binding protein-5 stimulates bone formation parameters in vitro and in vivo. (1999) (68)
Digit tip regrowth and differential gene expression in MRL/Mpj, DBA/2, and C57BL/6 mice (2007) (68)
Mechanical loading-induced gene expression and BMD changes are different in two inbred mouse strains. (2005) (68)
Local ex vivo gene therapy with bone marrow stromal cells expressing human BMP4 promotes endosteal bone formation in mice (2004) (67)
Insulin-like growth factor system components in hyperparathyroidism and renal osteodystrophy. (2000) (67)
Impaired skeletal growth in mice with haploinsufficiency of IGF-I: genetic evidence that differences in IGF-I expression could contribute to peak bone mineral density differences. (2005) (67)
Incidence of hip fractures in osteoporotic women treated with sodium fluoride (1987) (67)
The effects of estrone (Ogen) on spinal bone density of postmenopausal women. (1991) (65)
Fluid Shear Stress Synergizes with Insulin-like Growth Factor-I (IGF-I) on Osteoblast Proliferation through Integrin-dependent Activation of IGF-I Mitogenic Signaling Pathway* (2005) (65)
Development of a new radioimmunoassay for human osteocalcin: evidence for a midmolecule epitope. (1988) (65)
Fluoride therapy for the vertebral crush fracture syndrome. A status report. (1989) (65)
Influence of dietary vitamin D3 on the circulating concentration of its active metabolites in the chick and rat. (1977) (64)
Retinoic acid regulates insulin-like growth factor-binding protein expression in human osteoblast cells. (1996) (64)
Recombinant Human Insulin-Like Growth Factor-Binding Protein-5 Stimulates Bone Formation Parameters in Vitro and in Vivo1. (1999) (63)
Mechanical Strain Stimulates ROS Cell Proliferation Through IGF‐II and Estrogen Through IGF‐I (1999) (63)
Studies on regulation of insulin-like growth factor binding protein (IGFBP)-3 and IGFBP-4 production in human bone cells. (1992) (63)
1,25-Dihydroxyvitamin D3 increases secretion of insulin-like growth factor binding protein-4 (IGFBP-4) by human osteoblast-like cells in vitro and elevates IGFBP-4 serum levels in vivo. (1993) (61)
Congenic Strains of Mice for Verification and Genetic Decomposition of Quantitative Trait Loci for Femoral Bone Mineral Density (2003) (61)
Human skeletal growth factor: characterization of the mitogenic effect on bone cells in vitro. (1982) (60)
Characterization of mitogenic activities extracted from bovine bone matrix. (1986) (60)
Identification of mouse Duffy antigen receptor for chemokines (Darc) as a BMD QTL gene. (2007) (60)
Postmenopausal osteoporosis: proposed roles of defective coupling and estrogen deficiency. (1981) (60)
Extracts of bone contain a potent regulator of bone formation. (1982) (60)
Vitamin D intoxication in an anephric child. (1975) (59)
Sustained elevation of pulsatile growth hormone (GH) secretion and insulin-like growth factor I (IGF-I), IGF-binding protein-3 (IGFBP-3), and IGFBP-5 concentrations during 30-day continuous subcutaneous infusion of GH-releasing peptide-2 in older men and women. (2004) (59)
Effects of Secreted Frizzled‐Related Protein 3 on Osteoblasts In Vitro (2004) (59)
Quantification of skeletal alkaline phosphatase in osteoporotic serum by wheat germ agglutinin precipitation, heat inactivation, and a two-site immunoradiometric assay. (1994) (58)
Serum levels of insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-1 to -6 and their relationship to bone metabolism in osteoporosis patients. (2003) (58)
Neuroendocrine modulation of calcitonin and parathyroid hormone in man. (1978) (57)
Spontaneous Fractures in the Mouse Mutant sfx Are Caused by Deletion of the Gulonolactone Oxidase Gene, Causing Vitamin C Deficiency (2005) (57)
Alveolar atrophy and decreased skeletal mass of the radius. (1978) (57)
A time course of bone response to jump exercise in C57BL/6J mice (2002) (57)
Growth hormone (GH) treatment of GH-deficient children increases serum levels of insulin-like growth factors (IGFs), IGF-binding protein-3 and -5, and bone alkaline phosphatase isoenzyme. (1996) (56)
An inhibitory insulin-like growth factor binding protein (In-IGFBP) from human prostatic cell conditioned medium reveals N-terminal sequence identity with bone derived In-IGFBP. (1990) (56)
Influence of phosphate depletion on the biosynthesis and circulating level of 1alpha,25-dihydroxyvitamin D. (1977) (55)
Bone matrix and mineral abnormalities in postmenopausal osteoporosis. (1982) (55)
Identification of genetic loci that regulate bone adaptive response to mechanical loading in C57BL/6J and C3H/HeJ mice intercross. (2006) (54)
Autocrine regulators of MC3T3‐E1 cell proliferation (1993) (54)
Serum 1,25-Dihydroxyvitamin D: An Outcome Prognosticator in Human Sepsis (2013) (53)
Systemic factors in alveolar bone loss. (1974) (53)
Spaceflight Results in Formation of Defective Bone 1 (1985) (53)
1,25-Dihydroxyvitamin D3 stimulates both alkaline phosphatase gene transcription and mRNA stability in human bone cells. (1991) (52)
Serum Levels of Insulin‐like Growth Factor Binding Proteins (IGFBP)–4 and –5 Correlate with Bone Mineral Density in Growth Hormone (GH)–Deficient Adults and Increase with GH Replacement Therapy (1998) (52)
Ras‐Association Domain Family 1 Protein, RASSF1C, Is an IGFBP‐5 Binding Partner and a Potential Regulator of Osteoblast Cell Proliferation (2005) (52)
Serum insulin-like growth factor-I, insulin-like growth factor binding proteins, and bone mineral content in hyperthyroidism. (2000) (50)
Truncation of the amino terminus of PTH alters its anabolic activity on bone in vivo. (1996) (50)
Effects of recombinant insulin-like growth factor-binding protein-4 on bone formation parameters in mice. (1999) (50)
Calcium deficiency in fluoride-treated osteoporotic patients despite calcium supplementation. (1996) (49)
Human prostatic cancer cells, PC3, elaborate mitogenic activity which selectively stimulates human bone cells. (1990) (49)
Pregnancy-associated Plasma Protein-A Regulates Myoblast Proliferation and Differentiation through an Insulin-like Growth Factor-dependent Mechanism* (2005) (49)
Evidence that fluoride-stimulated 3[H]-thymidine incorporation in embryonic chick calvarial cell cultures is dependent on the presence of a bone cell mitogen, sensitive to changes in the phosphate concentration, and modulated by systemic skeletal effectors. (1988) (49)
Endogenous Inhibitor of Bone Cell Proliferation (1981) (49)
Studies on the Role of Human Insulin‐like Growth Factor‐II (IGF‐II)‐Dependent IGF Binding Protein (hIGFBP)‐4 Protease in Human Osteoblasts Using Protease‐Resistant IGFBP‐4 Analogs (1999) (48)
Embryonic bone matrix formation is increased after exposure to a low-amplitude capacitively coupled electric field, in vitro. (1986) (48)
In vivo and in vitro evidence that the high osteoblastic activity in C3H/HeJ mice compared to C57BL/6J mice is intrinsic to bone cells. (2004) (46)
Basal plasma immunoreactive calcitonin in postmenopausal osteoporosis. (1980) (46)
Vitamin D-enhanced osteocytic and osteoclastic bone resorption. (1973) (45)
Whole genome microarray analysis of growth hormone-induced gene expression in bone: T-box3, a novel transcription factor, regulates osteoblast proliferation. (2006) (45)
Circadian and longitudinal variation of serum C-telopeptide, osteocalcin, and skeletal alkaline phosphatase in C3H/HeJ mice. (2001) (45)
Quantitative trait loci for periosteal circumference (PC): identification of single loci and epistatic effects in F2 MRL/SJL mice. (2003) (44)
Isolation and purification of a low-molecular-weight skeletal growth factor from human bones. (1986) (43)
Treatment with the Oral Growth Hormone Secretagogue MK‐677 Increases Markers of Bone Formation and Bone Resorption in Obese Young Males (1998) (43)
Regulation of bone volume is different in the metaphyses of the femur and vertebra of C3H/HeJ and C57BL/6J mice. (2002) (42)
Phenytoin increases markers of osteogenesis for the human species in vitro and in vivo. (1995) (42)
Circulating levels of insulin-like growth factor-I and -II, and IGF-binding protein-3 in inflammation and after parathyroid hormone infusion. (1994) (42)
Genetic variation in bone-regenerative capacity among inbred strains of mice. (2001) (42)
Inhibition of bone matrix formation, mineralization, and resorption in thyroparathyroidectomized rats. (1973) (42)
Selective deficiency of 1,25-dihydroxycholecalciferol. A cause of isolated skeletal resistance to parathyroid hormone. (1977) (42)
Matrix formation and osteoid maturation in vitamin D-deficient rats made normocalcemic by dietary means (1980) (41)
Acute inhibition of mineralization and stimulation of bone resorption mediated by hypophosphatemia. (1975) (41)
Human skeletal growth factor stimulates collagen synthesis and inhibits proliferation in a clonal osteoblast cell line (MC3T3‐E1) (1986) (41)
Serum immunoreactive parathyroid hormone and 25-hydroxyvitamin D in patients with uremic bone diseases. (1975) (41)
Insulin‐like growth factor binding protein–4 inhibits both basal and IGF‐mediated chick pelvic cartilage growth in vitro (1993) (41)
Growth factors and electromagnetic fields in bone. (1994) (41)
Synthetic peptide-based immunoassay for amino-terminal propeptide of type I procollagen: application for evaluation of bone formation. (1993) (41)
Skeletal scintigraphic changes in osteoporosis treated with sodium fluoride: concise communication. (1984) (41)
Studies on human pregnancy-induced insulin-like growth factor (IGF)-binding protein-4 proteases in serum: determination of IGF-II dependency and localization of cleavage site. (2000) (40)
An age-related decrease in the concentration of insulin-like growth factor binding protein-5 in human cortical bone (1995) (40)
Expression of a Structurally Unique Osteoclastic Protein-tyrosine Phosphatase Is Driven by an Alternative Intronic, Cell Type-specific Promoter* (2003) (40)
Evidence that human bone cells in culture secrete insulin‐like growth factor (IGF)‐II and IGF binding protein‐3 but not acid‐labile subunit both under basal and regulated conditions (1995) (40)
Lack of insulin-like growth factor I exaggerates the effect of calcium deficiency on bone accretion in mice. (2003) (39)
Differential protein profile in the ear-punched tissue of regeneration and non-regeneration strains of mice: a novel approach to explore the candidate genes for soft-tissue regeneration. (2000) (39)
Total body calcium and long-term calcium balance in chronic renal disease. (1973) (39)
Evidence that sensitivity to growth hormone (GH) is growth period and tissue type dependent: studies in GH-deficient lit/lit mice. (2003) (39)
Effects of extracellular calcium on insulin‐like growth factor II in human bone cells (1995) (38)
PTH stimulates the proliferation of TE-85 human osteosarcoma cells by a mechanism not involving either increased cAMP or increased secretion of IGF-I, IGF-II or TGF beta. (1992) (38)
Regulation of DNA Synthesis in Chick Calvaria Cells by Factors from Bone Organ Culture (1981) (38)
Acute reduction in osteoclast number during bone repletion. (1982) (38)
Extracellular signal-regulated kinase-1 and -2 are both essential for the shear stress-induced human osteoblast proliferation. (2004) (38)
Quantitative Assessment of Forearm Muscle Size, Forelimb Grip Strength, Forearm Bone Mineral Density, and Forearm Bone Size in Determining Humerus Breaking Strength in 10 Inbred Strains of Mice (2001) (38)
A mouse tumor-derived osteolytic factor stimulates bone resorption by a mechanism involving local prostaglandins production in bone. (1985) (38)
Skeletal growth factor is produced by human osteoblast-like cells in culture. (1986) (37)
Effect of insulin-like growth factor-1 (IGF-1) plus alendronate on bone density during puberty in IGF-1-deficient MIDI mice. (2002) (37)
Molecular cloning and expression of a unique rabbit osteoclastic phosphotyrosyl phosphatase. (1996) (36)
Osteoblastic Tartrate‐Resistant Acid Phosphatase: Its Potential Role in the Molecular Mechanism of Osteogenic Action of Fluoride (2003) (36)
Femur Mechanical Properties in the F2 Progeny of an NZB/B1NJ × RF/J Cross Are Regulated Predominantly by Genetic Loci That Regulate Bone Geometry (2006) (36)
A urine midmolecule osteocalcin assay shows higher discriminatory power than a serum midmolecule osteocalcin assay during short-term alendronate treatment of osteoporotic patients. (2002) (35)
Histomorphometric analysis of iliac crest bone biopsies in placebo-treated versus fluoride-treated subjects (1995) (35)
Contribution of marrow stromal cells to the regulation of osteoblast proliferation in rats: evidence for the involvement of insulin-like growth factors. (1991) (35)
Phenytoin at Micromolar Concentrations is an Osteogenic Agent for Human-mandible-derived Bone Cells in vitro (1995) (35)
Leptin Receptor (Lepr) Is a Negative Modulator of Bone Mechanosensitivity and Genetic Variations in Lepr May Contribute to the Differential Osteogenic Response to Mechanical Stimulation in the C57BL/6J and C3H/HeJ Pair of Mouse Strains* (2010) (34)
Clinical performances of galactosyl hydroxylysine, pyridinoline, and deoxypyridinoline in postmenopausal osteoporosis. (1996) (34)
Monofluorophosphate physiology: the effects of fluoride on bone. (1983) (34)
Effects of short-term calcium depletion and repletion on biochemical markers of bone turnover in young adult women. (1998) (34)
Insulin-like growth factor-binding protein-6 produced by human PC-3 prostate cancer cells: isolation, characterization and its biological action. (1996) (34)
IGF System Components and Their Role in Bone Metabolism (1999) (34)
Hip mineral density in females with a recent hip fracture. (1992) (33)
Mitogenic action(s) of fluoride on osteoblast line cells: Determinants of the response In Vitro (1990) (33)
Inhibition of human osteoblast marker gene expression by retinoids is mediated in part by insulin-like growth factor binding protein-6. (2001) (33)
Prevention of Bone Loss With Tibolone in Postmenopausal Women: Results of Two Randomized, Double-Blind, Placebo-Controlled, Dose-Finding Studies (2002) (33)
Expression of the Fibroblast Growth Factor Receptor Genes in Fracture Repair (2002) (33)
Characterization of a rapidly responding animal model for fluoride-stimulated bone formation. (1986) (32)
The role of insulin-like growth factor II in magnetic field regulation of bone formation (1994) (32)
Mapping the dominant wound healing and soft tissue regeneration QTL in MRL × CAST (2005) (32)
A transmembrane osteoclastic protein-tyrosine phosphatase regulates osteoclast activity in part by promoting osteoclast survival through c-Src-dependent activation of NFkappaB and JNK2. (2007) (32)
Progesterone Stimulation of Human Insulin-like Growth Factor-binding Protein-5 Gene Transcription in Human Osteoblasts Is Mediated by a CACCC Sequence in the Proximal Promoter* (1999) (32)
The effects of two diphosphonates on bone metabolism in the rat (1979) (31)
Phosphotyrosyl protein phosphatases: potential regulators of cell proliferation and differentiation. (1993) (31)
The Regulation of Endosteal Bone Volume. (1979) (31)
Effect of beta-aminopropionitrile on bone mechanical properties. (1977) (31)
An osteoclastic protein-tyrosine phosphatase may play a role in differentiation and activity of human monocytic U-937 cell-derived, osteoclast-like cells. (2004) (31)
Evaluation of signal transduction mechanisms for the mitogenic effects of prostaglandin E2 in normal human bone cells in vitro (1996) (30)
Gene expression between a congenic strain that contains a quantitative trait locus of high bone density from CAST/EiJ and its wild-type strain C57BL/6J (2002) (30)
Quantitative trait loci, genes, and polymorphisms that regulate bone mineral density in mouse. (2009) (30)
Cellular and molecular mechanisms of accelerated fracture healing by COX2 gene therapy: studies in a mouse model of multiple fractures. (2013) (30)
Effect of Residual Dental Pulp Tissue on Regeneration of Dentin‐pulp Complex: An In Vivo Investigation (2018) (30)
Spontaneous fracture (sfx): a mouse genetic model of defective peripubertal bone formation. (2000) (30)
Effects of Recombinant Insulin-Like Growth Factor-Binding Protein-4 on Bone Formation Parameters in Mice1. (1999) (29)
Studies on the regulation of insulin‐like growth factor binding protein 3 secretion in human osteosarcoma cells in vitro (1994) (29)
Fluoride therapy for osteoporosis promotes a progressive increase in spinal bone density (1990) (29)
Effects of calcitonin on bone quality and osteoblastic function (1993) (29)
Transforming growth factor beta mediates the estrogen induced inhibition of UMR106 cell growth. (1989) (29)
Osteogenic Protein-1 Stimulates mRNA Levels of BMP-6 and Decreases mRNA Levels of BMP-2 and -4 in Human Osteosarcoma Cells (1997) (29)
Characterization of the receptor for insulin‐like growth factor II in bone cells (1989) (29)
A critical evaluation of the effect of population size and phenotypic measurement on QTL detection and localization using a large F2 murine mapping population (2006) (28)
In vitro metabolism of 25-hydroxyvitamin D3 by isolated rat kidney cells. (1980) (28)
Effect of low-dose of recombinant human growth hormone on bone metabolism in elderly women with osteoporosis. (2002) (28)
Genetic regulation of femoral bone mineral density: complexity of sex effect in chromosome 1 revealed by congenic sublines of mice. (2007) (28)
Differential regulation of pregnancy associated plasma protein (PAPP)-A during pregnancy in human and mouse. (2002) (28)
Fluoride at mitogenic doses induces a sustained activation of p44mapk, but not p42mapk, in human TE85 osteosarcoma cells. (1997) (28)
Insulin-like growth factor II and transforming growth factor beta 1 regulate insulin-like growth factor I secretion in mouse bone cells. (1991) (28)
The diagnosis and treatment of osteoporosis: future prospects. (1999) (28)
Bone cell mitogenic action of fluoroaluminate and aluminum fluoride but not that of sodium fluoride involves upregulation of the insulin-like growth factor system. (2002) (28)
Isolation of wound healing/regeneration genes using restrictive fragment differential display-PCR in MRL/MPJ and C57BL/6 mice. (2005) (27)
Development and Application of a Serum C-Telopeptide and Osteocalcin Assay to Measure Bone Turnover in an Ovariectomized Rat Model (2000) (27)
Growth factor-induced proliferation of osteoblasts measured by bromodeoxyuridine immunocytochemistry. (1991) (27)
Growth hormone stimulates cortical bone formation in immature hypophysectomized rats. (1992) (27)
Regulation of insulin-like growth factor binding protein-5, four and a half lim-2, and a disintegrin and metalloprotease-9 expression in osteoblasts. (2006) (27)
An osteoclastic protein‐tyrosine phosphatase is a potential positive regulator of the c‐Src protein‐tyrosine kinase activity: A mediator of osteoclast activity (2006) (27)
Fluoride at mitogenic concentrations increases the steady state phosphotyrosyl phosphorylation level of cellular proteins in human bone cells. (1996) (27)
BONE FORMATION AND RESORPTION BY OSTEOCYTES (1971) (27)
Basic science and clinical utility of biochemical markers of bone turnover--a Congress report. (2009) (26)
Serum insulin-like growth factor binding protein (IGFBP)-4 and IGFBP-5 levels in aging and age-associated diseases (1997) (26)
Targeted Overexpression of Osteoactivin in Cells of Osteoclastic Lineage Promotes Osteoclastic Resorption and Bone Loss in Mice (2012) (26)
Chromosomal regions harboring genes for the work to femur failure in mice (2002) (26)
Chick osteoblasts contain fluoride-sensitive acid phosphatase activity. (1988) (26)
Metabolism of 25(OH)D3 to 1,25(OH)2D3 and 24,25(OH)2D3 by chick chorioallantoic cells in culture. (1980) (25)
High Osteoblastic Activity In C3H/HeJ Mice Compared to C57BL/6J Mice Is Associated with Low Apoptosis in C3H/HeJ Osteoblasts (2006) (25)
Measurement of bone mineral content in the term and preterm infant. (1987) (25)
Multiple Genetic Loci From CAST/EiJ Chromosome 1 Affect vBMD Either Positively or Negatively in a C57BL/6J Background (2005) (25)
Alterations in calcium, phosphorus and C-terminal parathyroid hormone levels in equine acute renal disease. (1986) (25)
A New Monoclonal Antibody ELISA for Detection and Characterization of C-telopeptide Fragments of Type I Collagen in Urine (2001) (24)
Evidence that fluoride therapy increases trabecular bone density in a peripheral skeletal site. (1993) (24)
Evidence that the inhibition of TE85 human bone cell proliferation by agents which stimulate cAMP production may in part be mediated by changes in the IGF-II regulatory system. (1991) (24)
Effect of skeletal alkaline phosphatase inhibitors on bone cell proliferation in vitro. (1982) (23)
Stimulation of cellular alkaline phosphatase activity and its messenger RNA level in a human osteosarcoma cell line by 1,25-dihydroxyvitamin D3. (1989) (23)
Characterization of the IGF regulatory system in bone. (1993) (23)
Calvarial cells synthesize 1 alpha,25-dihydroxyvitamin D3 from 25-hydroxyvitamin D3. (1983) (23)
Dibutyryl cyclic adenosine monophosphate differentially regulates cell proliferation in low and high alkaline phosphatase SaOS‐2 human osteosarcoma cells: Evidence for mediation by the insulin‐like growth factor‐II system (1993) (22)
Effect of Combined Risedronate and Hormone Replacement Therapies on Bone Mineral Density in Postmenopausal Women (2001) (22)
Differential Effects of Two Protein Tyrosine Kinase Inhibitors, Tyrphostin and Genistein, on Human Bone Cell Proliferation as Compared with Differentiation (1998) (22)
Mouse genetic model for bone strength and size phenotypes: NZB/B1NJ and RF/J inbred strains. (2002) (21)
Development and evaluation of C-telopeptide enzyme-linked immunoassay for measurement of bone resorption in mouse serum. (2000) (21)
Cells isolated from embryonic intestine synthesize 1,25-dihydroxyvitamin-D3 and 24,25-dihydroxyvitamin-D3 in culture. (1983) (21)
Chemical and biological characterization of low-molecular-weight human skeletal growth factor. (1986) (21)
Stimulation of Bone Formation and Bone Resorption by Fluoride in Thyroparathyroidectomized Rats (1977) (21)
The effect of prolonged fluoride therapy for osteoporosis: Bone composition and histology (1989) (21)
Structure and characterization of the human insulin-like growth factor binding protein (IGFBP)-6 promoter: identification of a functional retinoid response element. (2001) (21)
Insulin‐Like Growth Factor I Effect on the Number of Osteoblast Progenitors Is Impaired in Ovariectomized Mice (2002) (21)
Demonstration of reduced mitogenic and osteoinductive activities in demineralized allogeneic bone matrix from vitamin D-deficient rats. (1988) (21)
Regulation of bone repletion in rats subjected to varying low-calcium stress. (1984) (20)
Low dose phenytoin is an osteogenic agent in the rat (2004) (20)
New quantitative trait loci that regulate wound healing in an intercross progeny from DBA/1J and 129×1/SvJ inbred strains of mice (2006) (20)
Osteoporosis: radiographic detection of fluoride-induced extra-axial bone formation. (1986) (20)
Hypercalcemia induced by prostaglandin E2 in thyroparathyroidectomized but not intact rats. (1977) (20)
Hypercalcemia, Excessive Bone Resorption, and Neutrophilia in Mice Bearing a Mammary Carcinoma (1983) (19)
Insulin-like growth factor-I and insulin-like growth factor-II induce c-fos in mouse osteoblastic cells (1990) (19)
Prevention of colorectal cancer with vitamin D (2010) (19)
HSV-1 amplicon-mediated transfer of 128-kb BMP-2 genomic locus stimulates osteoblast differentiation in vitro. (2004) (19)
Disruption of Four-and-a-Half LIM 2 Decreases Bone Mineral Content and Bone Mineral Density in Femur and Tibia Bones of Female Mice (2006) (19)
Use of 1,25(OH)2-vitamin D3 to separate 'types' on renal osteodystrophy. (1977) (19)
Purification and N-terminal sequence of two tartrate-resistant acid phosphatases type-5 from the hairy cell leukemia spleen. (1989) (19)
The effects of phosphate depletion on bone. (1978) (19)
Fluoride Therapy for Osteoporosis (2001) (18)
Mapping quantitative trait loci that influence blood levels of alkaline phosphatase in MRL/MpJ and SJL/J mice. (2004) (18)
Novel loci regulating bone anabolic response to loading: expression QTL analysis in C57BL/6JXC3H/HeJ mice cross. (2007) (18)
Local administration of AAV-DJ pseudoserotype expressing COX2 provided early onset of transgene expression and promoted bone fracture healing in mice (2015) (18)
An Improved Mouse Sca-1+ Cell-Based Bone Marrow Transplantation Model for Use in Gene- and Cell-Based Therapeutic Studies (2006) (18)
Phenytoin and fluoride act in concert to stimulate bone formation and to increase bone volume in adult male rats (1995) (18)
The selective cyclooxygenase-2 inhibitor celecoxib reduces bone resorption, but not bone formation, in ovariectomized mice in vivo. (2007) (18)
Mechanism of mitogenic action of aluminum ion on human bone cells: potential involvement of the insulin-like growth factor regulatory system. (1993) (18)
Beta 2-microglobulin is not a bone cell mitogen. (1989) (18)
Sca-1+ Hematopoietic Cell-based Gene Therapy with a Modified FGF-2 Increased Endosteal/Trabecular Bone Formation in Mice. (2007) (18)
Incorporation of sodium fluoride into cortical bone does not impair the mechanical properties of the appendicular skeleton in rats (1992) (17)
Quantitative trait loci that harbor genes regulating muscle size in (MRL/MPJ x SJL/J) F(2) mice. (2002) (17)
Radioligand Receptor Assay for 25-Hydroxyvitamin D2/D3 and la,25-Dihydroxyvitamin D2/D3 APPLICATION TO HYPERVITAMINOSIS D MMu (17)
Characterization of an animal model of pregnancy-induced vitamin D deficiency due to metabolic gene dysregulation. (2014) (17)
Osteogenic protein-1 stimulates production of insulin-like growth factor binding protein-3 nuclear transcripts in human osteosarcoma cells. (1997) (17)
Concentrations of insulin-like growth factor (IGF)-I, -II, and IGF binding protein-4, and -5 in human bone cell conditioned medium do not change with age (2000) (17)
Spinal fractures during fluoride therapy for osteoporosis: Relationship to spinal bone density (1992) (17)
Identification of Novel Genetic Loci for Bone Size and Mechanosensitivity in an ENU Mutant Exhibiting Decreased Bone Size (2004) (17)
A genomewide screening of N-ethyl-N-nitrosourea-mutagenized mice for musculoskeletal phenotypes. (2003) (17)
Further evidence supporting the phosphate leak hypothesis of idiopathic hypercalciuria. (1978) (17)
Bone repletion in calcium deficient rats fed a high calcium diet (2005) (17)
Copurification of osteolytic and transforming growth factor beta activities produced by human lung tumor cells associated with humoral hypercalcemia of malignancy. (1989) (16)
Picomolar norethindrone in vitro stimulates the cell proliferation and activity of a human osteosarcoma cell line and increases bone collagen synthesis without an effect on bone resorption (1994) (16)
Localization of the IGF binding domain and evaluation of the role of cysteine residues in IGF binding in IGF binding protein-4. (2001) (16)
Sequence comparison and predicted structure for the four exon-encoded regions of human insulin-like growth factor binding protein 4. (1995) (16)
Conditional deletion of IGF-I in osteocytes unexpectedly accelerates bony union of the fracture gap in mice. (2016) (16)
Construction of a Tc1-like transposon Sleeping Beauty-based gene transfer plasmid vector for generation of stable transgenic mammalian cell clones. (2002) (16)
Development and Application of a Synthetic Peptide-Based Osteocalcin Assay for the Measurement of Bone Formation in Mouse Serum (2000) (16)
Evidence that human bone cells in culture contain binding sites for osteogenic protein-1. (1994) (16)
Identification of quantitative trait loci that regulate obesity and serum lipid levels in MRL/MpJ × SJL/J inbred mice Published, JLR Papers in Press, October 27, 2005. (2006) (16)
Purification and N-terminal amino acid sequence of the tartrate-resistant acid phosphatase from human osteoclastoma: evidence for a single structure. (1990) (15)
The role of IGF system in the rise and fall in bone density with age. (2007) (15)
Vitamin D-enhanced osteoclastic bone resorption at vascualr canals. (1974) (15)
Osteogenic actions of phenytoin in human bone cells are mediated in part by TGF‐β1 (1996) (15)
The Effect of βAminopropionitrile (BAPN) on Bone Mineralization 1 (1977) (14)
Immobilization and its effect on bone repletion in calcium-deficient rats fed a high calcium diet (1978) (14)
Normal growth despite GH, IGF-I and IGF-II deficiency. (1999) (14)
Quantitative trait loci (QTL) for lean body mass and body length in MRL/MPJ and SJL/J F2 mice (2002) (14)
Acute Effects of Calcitonin Nasal Spray on Serum C-telopeptide of Type 1 Collagen (CTx) Levels in Elderly Osteopenic Women with Increased Bone Turnover (2004) (14)
Mapping quantitative trait loci that influence serum insulin-like growth factor binding protein-5 levels in F2 mice (MRL/MpJ X SJL/J). (2003) (14)
Quantitative trait loci (QTL) for lean body mass and body length in MRL/MPJ and SJL/J F(2) mice. (2002) (14)
Bone repletion in vitro: evidence for a locally regulated bone repair response to PTH treatment. (1988) (14)
Synthesis of 1,25-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol by calvarial cells. Characterization of the enzyme systems. (1987) (14)
Detecting Novel Bone Density and Bone Size Quantitative Trait Loci Using a Cross of MRL/MpJ and CAST/EiJ Inbred Mice (2007) (14)
Effects of medroxyprogesterone acetate on some parameters of calcium metabolism in patients with glucocorticoid-induced osteoporosis. (1991) (14)
Skeletal alkaline phosphatase activity in serum. (1995) (14)
Bone cells on microcarrier spheres. (1983) (14)
Factors affecting bone enzymatic activity in vitamin D-deficient rats. (1971) (14)
Covalent interaction between proform of eosinophil major basic protein (proMBP) and pregnancy-associated plasma protein-A (PAPP-A) is a cell-mediated event and required for proMBP inhibition of the catalytic activity of PAPP-A. (2004) (14)
Modifications of the fibroblast growth factor‐2 gene led to a marked enhancement in secretion and stability of the recombinant fibroblast growth factor‐2 protein (2007) (13)
Mapping genetic loci that regulate lipid levels in a NZB/B1NJ×RF/J intercross and a combined intercross involving NZB/B1NJ, RF/J, MRL/MpJ, and SJL/J mouse strains Published, JLR Papers in Press, May 13, 2007. (2007) (13)
Biochemical Markers For Bone Formation and Bone Resorption (1989) (13)
The effect of prolonged fluoride therapy for osteoporosis: bone composition and histology. (1990) (13)
Mechanistic study of the cause of decreased blood 1,25-Dihydroxyvitamin D in sepsis (2019) (13)
Altered bone turnover during spaceflight. (1979) (13)
Efficacy of long-term fluoride and calcium therapy in correcting the deficit of spinal bone density in osteoporosis. (1989) (13)
Effect of bone matrix-derived growth factors on skull and tibia in the growing rat. (1988) (12)
The diagnosis and management of osteoporosis (2000) (12)
Pore Size Measurements and Some Age-Related Changes in Human Alveolar Bone and Rat Femur (1977) (12)
Galactosyl Hydroxylysine and Deoxypyridinoline: A Methodological Comparison (1993) (12)
Evaluation of IGF System Component Levels and Mitogenic Activity of Uremic Serum on Normal Human Osteoblasts (2000) (12)
Monofluorophosphate is hydrolyzed by alkaline phosphatase and mimics the actions of NaF on skeletal tissues,In Vitro (2007) (12)
Pretreatment with low doses of norethindrone potentiates the osteogenic effects of fluoride on human osteosarcoma cells (1995) (12)
Evaluation of the usefulness of serum phosphatases and osteocalcin as serum markers in a calcium depletion-repletion rat model (1991) (12)
Quantitative trait loci that harbor genes regulating muscle size in (MRL/MPJ × SJL/J) F2 mice (2002) (12)
Bone-derived factors active on bone cells (2006) (12)
A chemical mutagenesis screen to identify modifier genes that interact with growth hormone and TGF-beta signaling pathways. (2008) (11)
The role of skeletal calcium deficiency in postmenopausal osteoporosis (1986) (11)
Effects of dietary calcium depletion and repletion on dynamic determinants of tibial bone volume in two inbred strains of mice. (2000) (11)
CHAPTER 19 – Role of Growth Hormone/Insulin-like Growth Factor Axis (1999) (10)
Osteocyte-Derived Insulin-Like Growth Factor I Is Not Essential for the Bone Repletion Response in Mice (2015) (10)
Regulation of plasma 1α,25 dihydroxyvitamin D by calcium and phosphate (1975) (10)
Evidence that tartrate-resistant acid phosphatases from osteoclastomas and hairy cell leukemia spleen are members of a multigene family. (1991) (10)
Differential response in alveolar bone osteoclasts residing at two different bone sites (1984) (10)
Effect of sodium fluoride on bone density in chickens (1992) (10)
Effect of fibrillar structure of pericanalicular and intercanalicular bone on X‐ray absorption (1970) (10)
Construction of a BAC Contig for a 3 cM Biologically Significant Region of Mouse Chromosome 1 (2004) (9)
Osteoporosis in corticosteroid-treated asthmatic patients: clinical correlates. (1993) (9)
Vitamin D status and metabolism in an ovine pregnancy model: effect of long-term, high-altitude hypoxia. (2016) (9)
Studies on regulation of IGF (insulin-like growth factor)-binding protein (IGFBP) 4 proteolysis by pregnancy-associated plasma protein-A (PAPP-A) in cells treated with phorbol ester. (2004) (9)
Effect of dichloromethylene diphosphonate on bone metabolism in calcium and phosphorus-depleted rats. (1983) (9)
The Effect of Vitamin D Deficiency on Bone Repletion (1981) (9)
Excretion of Sweat and Urine Pyridinoline Crosslinks in Healthy Controls and Subjects with Established Metabolic Bone Disease (2001) (9)
Progress toward skeletal gene therapy. (2004) (8)
Opposing Changes in Osteocalcin Levels in Bone vs Serum During the Acquisition of Peak Bone Density in C3H/HeJ and C57BL/6J Mice (2002) (8)
Effect of space flight on bone strength. (1979) (8)
Preliminary report: correlation of total body calcium (bone mass), as determined by neutron activation analysis with regional bone mass as determined by photon absorption (1975) (8)
Evidence for arrested bone formation during spaceflight (1982) (8)
Fluoride therapy for osteoporosis: A review of dose response, duration of treatment, and skeletal sites of action (2007) (8)
Theoretical physical chemical studies of the cause of fluoride‐induced osteomalacia (1990) (8)
Sodium fluoride does not increase human bone cell proliferation or protein synthesis in vitro (2004) (8)
Idiopathic hypercalciuria: The 'phosphate leak' hypothesis and the effects of oral phosphate supplement (1977) (8)
Mouse chromosome 9 quantitative trait loci for soft tissue regeneration: Congenic analysis and fine mapping (2007) (7)
Identification and characterization of novel IGFBP5 interacting protein: evidence IGFBP5-IP is a potential regulator of osteoblast cell proliferation. (2006) (7)
Sodium fluoride does not increase human bone cell proliferation or protein synthesis in vitro. (1992) (7)
Marrow Stromal Cell-Based Cyclooxygenase 2 Ex Vivo Gene-Transfer Strategy Surprisingly Lacks Bone-Regeneration Effects and Suppresses the Bone-Regeneration Action of Bone Morphogenetic Protein 4 in a Mouse Critical-Sized Calvarial Defect Model (2009) (7)
Effects of calcium depletion and repletion on serum insulin-like growth factor I and binding protein levels in weanling rats. (1998) (6)
Application of Genomic Resources and Gene Expression Profiles to Identify Genes That Regulate Bone Density (2003) (6)
Sca-1(+) hematopoietic cell-based gene therapy with a modified FGF-2 increased endosteal/trabecular bone formation in mice. (2007) (6)
Pharmacokinetic profile of a new fluoride preparation: Sustained-release monofluorophosphate (2004) (6)
Structural and functional analysis of the 5'-flanking region of the human insulin-like growth factor binding protein (IGFBP)-4 gene. (1997) (6)
Dexamethasone enhances the osteogenic effects of fluoride in human TE85 osteosarcoma cellsin vitro (1996) (6)
Analytical and clinical evaluation of the Bio-Rad HPLC kit for measurement of type I collagen cross links (2003) (5)
Intestinal metabolism and portal venous transport of 1,25(OH)2D3, 25(OH)D3, and vitamin D3 in the rat. (1985) (5)
Systemic influences on the bone response to dental and orthopedic implants. (1988) (5)
Quantitation of growth factors in ossein-mineral-compound. (1991) (5)
Experiment K305: Quantitative analysis of selected bone parameters (1981) (5)
Increased immunoreactive calcitonin in idiopathic hypercalciuria. (1981) (5)
The increase in spinal bone density that occurs in response to fluoride therapy for osteoporosis is not maintained after the therapy is discontinued (2005) (5)
The regulation of endosteal bone volume. (1979) (5)
Development of a synthetic peptide-based tartrate-resistant acid phosphatase radioimmunoassay for the measurement of bone resorption in rat serum (2002) (4)
[27] Purification of bovine skeletal growth factor (1987) (4)
On fluoride and bone strength (2004) (4)
1,25-Dihydroxyvitamin D: Response to and Production by Bone Cells (1984) (4)
The Actions and Therapeutic Applications of 1α-Hydroxylated Derivatives of Vitamin D (1994) (4)
BEYOND CARRIER PROTEINS IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms (2002) (4)
Protein Tyrosine Kinase Inhibitors Block the Stimulatory Actions of Phosphotyrosine Phosphatase Inhibitors to Increase Cell Proliferation, Alkaline Phosphatase Activity, and Collagen Synthesis in Normal HumanBone Cells (2000) (4)
Resorption of bone implants (1978) (4)
Clinical Use of Fluoride in Osteoporosis (1990) (4)
In vitro evidence that local and systemic skeletal effectors can regulate3[H]-thymidine incorporation in chick calvarial cell cultures and modulate the stimulatory actions(s) of embryonic chick bone extract (2007) (4)
Parathyroid hormone release is not associated with acute sympathetic arousal in goats. (1979) (3)
Mapping of the chromosome 17 BMD QTL in the F2 male mice of MRL/MpJ × SJL/J (2008) (3)
Bone mineralization and metabolism of3H-25-hydroxyvitamin D3 in thyroparathyroidectomized rats treated with parathyroid extract (1979) (3)
Fluoride therapy for the vertebral crush fracture syndrome: A status report (1990) (3)
Epiphyseal Plate Shear Strength in Rats Treated with a Diphosphonate (1980) (3)
Bone cell and hormone changes during bone repletion. (1982) (3)
Differences in exposure to stimulatory and inhibitory components of the insulin-like growth factor (IGF) system in patients with femoral neck versus trochanteric fracture. (2005) (3)
Effect of progesterone on the mRNA levels of insulin-like-growth factors (IGFs), IGF-binding proteins (JGFBPs) and type-1 and -type-2 igfreceptors in human osteoblastic cells (1992) (3)
Specific binding of estrogen to nuclei from Japanese quail kidney cells. (1978) (3)
The effects of the insulin-like growth factors and transforming growth factor β on the jun proto-oncogene family in MC3T3-E1 cells (1994) (3)
Comparison of rates of change in bone density as measured by dual-energy X-ray absorptiometry and quantitative computed tomography in osteoporotic females treated with fluoride. (1998) (3)
24,25(OH)2D3, bone formation, and bone resorption in vitamin D-deficient, azotemic rats (1984) (3)
The effects of the insulin-like growth factors and transforming growth factor beta on the Jun proto-oncogene family in MC3T3-E1 cells. (1994) (3)
The effect of beta-aminopropionitrile (BAPN) on bone mineralization. (1977) (3)
Rationale for active vitamin D analog therapy in senile osteoporosis (2009) (3)
Near-total parathyroidectomy in chronic dialysis patients. (1976) (3)
Serum fluoride and serum osteocalcin levels in response to a novel sustained-release monofluorophosphate preparation: Comparison with plain monofluorophosphate (2005) (3)
A Correction: Inhibitory Activity in the Conditioned Medium of Embryonic Chick Bones Is Due to Thymidine (1984) (2)
APPLICATION TO HYPERVITAMINOSIS D (1976) (2)
Effect of treatment with parathyroid extract on bone parameters and metabolism of 3H-25-hydroxyvitamin D3 in Hypocalcemic Thyroparathyroidectomized Rats (1979) (2)
Isolation and partial purification of a putative coupling factor from human bone. (1981) (2)
Implants: Systemic influences. (1987) (2)
Purification of bovine skeletal growth factor. (1987) (2)
Plasma immunoreactive calcitonin in postmenopausal osteoporosis (1979) (2)
Transgenic overexpression of pregnancy-associated plasma protein-A in skeletal muscle of mice increases myofiber size and central nucleation in sedentary muscle and promotes muscle regeneration in the injured muscle. (2012) (2)
and width in mice I collagen-expressing cells reduces bone length α type II Disruption of insulin-like growth factor-I expression in (2015) (2)
Estrogen receptors in the regulation of skeletal maturation and the GH/IGF-I axis in male mice. (2000) (2)
Quantitative trait loci for femoral and lumbar vertebral bone mineral density in C57BL/6J and C3h/HeJ inbred strains of mice. (2001). (2005) (2)
Bovine skeletal growth factor stimulates protein phosphorylation of chicken bone cells in vitro. (1988) (2)
Increased bone microhardness in fluoride treated rats (1974) (2)
A platform of high-efficiency nonviral gene transfer in mouse osteoblast cells in vitro (2006) (2)
A role for prostaglandin E (PGE) in the hypercalcemia of human cancer (1975) (2)
Coupled bone metabolism in vitro: embryonic chick limbs in organ culture. (1982) (2)
An improved technique for rapid autoradiography of cells and tissue sections (2004) (2)
Osteogenic Actions of Fluoride: Its Therapeutic Use for Established Osteoporosis (2013) (2)
1.25-Dihydroxyvitamin D3 increases secretion of inhibitory insulin-like growth factor binding protein-4 and inhibits mitogenesis in osteoblastic cells (1992) (2)
METHOD FOR MEASUREMENT OF DENSITY AND CROSS-SECTIONAL AREA OF THE FEMORAL CORTEX USING COMPUTED TOMOGRAPHY (1985) (2)
Drug therapy for prevention and treatment of osteoporosis (1989) (2)
CHAPTER 48 – Fluoride Therapy of Established Osteoporosis (1999) (1)
Predictions on future diagnosis and treatment of osteoporosis: Results and discussion of a recent opinion poll (1995) (1)
Serum fluoride and bone formation parameters in response to a novel sustained release monofluorophosphate (MEP-SR), comparison with plain MFP (2006) (1)
Evidence for a lack of functional receptors for nerve growth factor (NGF) in chick bone cells in vitro (1992) (1)
Development of nonviral basic FGF expression plasmids for ex vivo gene therapy of bone (1999) (1)
Preliminary Results of the Antineoplastic Activity of a Marine Terpenoid in Human Cancer Cell Lines (2000) (1)
BONE DENSITY IN THE SPINE BY CT AND IN THE RADIUS BY PHOTON ABSORPTION IN OSTEOPOROSIS (1983) (1)
Biochemical Markers in the Diagnosis and Treatment of Osteoporosis (1996) (1)
Effects of zinc and other nutritional factors on insulin-like growth factor I and insulin-like growth factor binding proteins in postmenopausal women 1 – 3 (1)
[Autocrine regulation of cell proliferation and secretion of insulin-like growth factor I (IGF-I) in osteoblastic cell line MC3T3-E1]. (1994) (1)
Molecular Genetic Studies of Bone Mechanical Strain and of Pedigrees with Very High Bone Density (2002) (0)
The skeletal concentration of transforming growth factor beta in rats is selectively diminished by ovariectomy (1992) (0)
OR5,27 A novel approach involving a sensitized chemical mutagenesis screen to identify genes that interact with GH signaling pathway to regulate skeletal phenotype (2010) (0)
Fluoride at Mitogenic Doses Induces a Sustained Activation of p44, but Not p42, in Human TE85 Osteosarcoma Cells* (1997) (0)
Inhibition ofBoneMiatrix Formation, Mineralization, andResorption in Thyroparathyroidectomized Rats (1973) (0)
Concomitant phenytoin therapy doubles the osteogenic and densitometric effect of fluoride therapy in osteoporosis (2006) (0)
AUGMENTATING OSTEOINTEGRATION OF PROSTHETIC MPLANT DEVICES (2017) (0)
Resorption of bone implants. The effect of in vivo incorporation of a diphosphonate and fluoride on resorption. (1978) (0)
changes are different in two inbred mouse strains Mechanical loading-induced gene expression and BMD (2015) (0)
[Effect of fluorides on the mineralization of rat bones]. (1971) (0)
ENU mutation mapped to a distal region of chromosome 11 is a major determinant of bone size. (2013) (0)
Patients with Van Buchem's disease, an osteosclerotic genetic disease, have a higher bone density and a greater polar moment of inertia. (2000) (0)
Increased Immunoreactive CalcitHin in Idiopathic Hypercalciuria (1981) (0)
Purification of a tartrate-resistant acid phosphatase (TrACP) from bovine cortical bone matrix (1986) (0)
ImprovedMethodfor QuantitativeDeterminationin Serumof Alkaline (2004) (0)
23: DISCOVERY OF A NOVEL OUTCOME PROGNOSTICATOR FOR SEPSIS WITH THERAPEUTIC IMPLICATIONS (2012) (0)
EVIDENCE OF A ROLE FOR VITAMIN D AND TRANSFORMING GROWTH FACTOR P IN OSTEOINDUCTION (1991) (0)
The therapy of osteoporosis. (1969) (0)
794. Retroviral-Based Gene Therapy with Cyclo-Oxygenase-2 Promotes Bony Union and Accelerates Fracture Healing in the Rat (2006) (0)
Bone growth-promoting composition (1992) (0)
91136133 Effects of medroxyprogesterone acetate on some parameters of calcium metabolism in patients with glucocorticoid-induced osteoporosis (1991) (0)
Bone resorption in vitro: Effects of a physiologic dose of parathyroid hormone (1979) (0)
Effects of insulin like growth factors I & II on cell activity and calcitriol receptor levels in human bone cells in vitro (1995) (0)
Physical and biochemical changes occurring in bone as a result of gravity counteraction Semiannual report (1967) (0)
Aminoterminal procollagen 1 (i) peptides (1993) (0)
038 Digit Tip Regeneration and Global Gene Expression Profiling in the MRL SuperHealer Mouse (2008) (0)
449. Sca-1+ Cell-Based Gene Therapy with a Modified Fibroblast Growth Factor 2 (FGF2) Increased Endosteal/Trabecular Bone Formation in Mice (2006) (0)
A process for the release of ligand-binding proteins (1994) (0)
Thyroparathyroidectomized Rats Stimulation of Bone Formation and Bone Resorption by Fluoride in (2011) (0)
The effect of vitamin D deficiency on bone replacement. (1981) (0)
Normophosphatemic vitamin D-resistant osteomalacia in a patient with normal calcium and fat absorption. (1971) (0)
A NEW SURGICAL TECHNIQUE THAT ENHANCES VECTOR APPLICATION FOR GENE THERAPY IN THE RAT FEMUR FRACTURE MODEL.: 187 (2004) (0)
Evidence that second messenger responses are differentiation stage dependent (1993) (0)
[Treatment of osteoporosis with fluoride]. (1993) (0)
regulator of osteoblast cell proliferation interacting protein: evidence IGFBP5-IP is a potential Identification and characterization of novel IGFBP5 (2016) (0)
Humoral Hypercalcemia of Malignancy Activities Produced by Human Lung Tumor Cells Associated β Copurification of Osteolytic and Transforming Growth Factor Updated (2006) (0)
Biophysical stimulation of tissue healing mediated by IGF-II (1992) (0)
Isolated skeletal resistance to parathyroid hormone (PTH): correction with 1,25 dihydroxycholecalciferol (DHCC) therapy (1977) (0)
Coupling of Bone Formation and Bone Resorption: A Model (1998) (0)
OR06-1 CRE/LOXP-MEDIATED INACTIVATION OF IGF-I GENE IN TYPE I COLLAGEN EXPRESSING CELLS PRODUCES NEONATAL LETHALITY AND A DRAMATIC EFFECT ON SKELETAL PHENOTYPE (2006) (0)
Commentaryon "Restoration of Bone Mass in the Severely Osteopenic Senescent Rat' (2001) (0)
Upregulation of a novel autocrine synthetic pathway for 1,25-dihydroxy-vitamin D3 in intestinal epithelial cells: P-0068. (2008) (0)
Contents, Vol. 17, Supplement 1, 1983 (1983) (0)
Characterization of the responsiveness of the preosteoblasts in human bone marrow to TGF-Beta and calcitriol in vitro (1995) (0)
The Role of Insulin-Like Growth Factor Binding Protein-5 in Bone (1997) (0)
A calcium deficient diet impairs coupling of bone formation to bone resorption in young adults (1992) (0)
Synthesis of 1,25 (OH)2D3 by isolated mammalian kidney cells (1980) (0)
Use of a bone growth promoting composition (1991) (0)
Molecular Mechanisms of Soft Tissue Regeneration and Bone Formation in Mice: Implications in Fracture Repair and Wound Healing in Humans (2000) (0)
The renal metabolism of 25-hydroxyvitamin D3 in the rat: Regulation by 1,25-dihydroxyvitamin D3 (1983) (0)
91334007 The effects of estrone (Ogen) on spinal bone density of postmenopausal women (1992) (0)
Elevation of serum calcitonin in idiopathic hypercalciuria (1979) (0)
Role of Insulin-Like Growth Factor Binding Proteins and Their Proteases (1997) (0)
Growth Hormone Axis-Independent Growth. A Case Report 438 (1998) (0)
187 A NEW SURGICAL TECHNIQUE THAT ENHANCES VECTOR APPLICATION FOR GENE THERAPY IN THE RAT FEMUR FRACTURE MODEL. (2004) (0)
Growth factors: Potential treatment of osteoporosis (1995) (0)
Differential activation of nuclear factor‐kappa B in healing tissue of poor healer SJL strain and good healer MRL strain: Implications in wound repair and regeneration (2006) (0)
Development of a heterologous radioimmunoassay for canine osteocalcin (1994) (0)
Growth hormone axis-independent growth (1998) (0)
The Mitogenic Action of Fluoride on Human Bone Cells (1998) (0)
Gene Therapy for Fracture Repair (2003) (0)
AD Award Number : DAMD 17-011-0744 TITLE : Molecular Genetic Studies of Bone Mechanical Strain and of Pedigrees with Very High Bone Density PRINCIPAL INVESTIGATOR : (0)

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