David J. Hartshorne
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Cell Biology
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Biology
David J. Hartshorne's Degrees
- PhD Cell Biology University of California, San Francisco
- Bachelors Biology University of California, Berkeley
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(Suggest an Edit or Addition)David J. Hartshorne's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Distinct Roles of Rock (Rho-Kinase) and Mlck in Spatial Regulation of Mlc Phosphorylation for Assembly of Stress Fibers and Focal Adhesions in 3t3 Fibroblasts (2000) (690)
- Inhibitory Phosphorylation Site for Rho-associated Kinase on Smooth Muscle Myosin Phosphatase* (1999) (553)
- Myosin phosphatase: Structure, regulation and function (2004) (442)
- Modulator protein as a component of the myosin light chain kinase from chicken gizzard. (1978) (414)
- Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fibroblasts (2004) (387)
- Hepatocyte deformation induced by cyanobacterial toxins reflects inhibition of protein phosphatases. (1990) (339)
- Phosphorylation of smooth muscle myosin at two distinct sites by myosin light chain kinase. (1985) (332)
- Activation of RhoA and Inhibition of Myosin Phosphatase as Important Components in Hypertension in Vascular Smooth Muscle (2003) (332)
- Myosin light chain phosphatase: subunit composition, interactions and regulation (1998) (329)
- Characterization of the myosin-binding subunit of smooth muscle myosin phosphatase. (1994) (264)
- Role of Protein Phosphatase Type 1 in Contractile Functions: Myosin Phosphatase* (2004) (228)
- Smooth Muscle Phosphatase Is Regulated in Vivo by Exclusion of Phosphorylation of Threonine 696 of MYPT1 by Phosphorylation of Serine 695 in Response to Cyclic Nucleotides* (2004) (224)
- Regulation of smooth muscle actomyosin. (1982) (221)
- Identification, phosphorylation, and dephosphorylation of a second site for myosin light chain kinase on the 20,000-dalton light chain of smooth muscle myosin. (1986) (215)
- Identification of the endogenous smooth muscle myosin phosphatase-associated kinase (2001) (212)
- Phosphorylation of the 20,000-dalton light chain of smooth muscle myosin by the calcium-activated, phospholipid-dependent protein kinase. Phosphorylation sites and effects of phosphorylation. (1987) (210)
- Phosphorylation of the Large Subunit of Myosin Phosphatase and Inhibition of Phosphatase Activity (*) (1996) (207)
- Roles of calcium and phosphorylation in the regulation of the activity of gizzard myosin. (1978) (201)
- Inhibition of Rho‐associated kinase blocks agonist‐induced Ca2+ sensitization of myosin phosphorylation and force in guinea‐pig ileum (2000) (189)
- Myosin phosphatase target subunit: Many roles in cell function. (2008) (184)
- Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase. (2002) (167)
- [30] Smooth muscle myosin light chain kinase (1983) (161)
- A Ca2+-and modulator-dependent myosin light chain kinase from non-muscle cells. (1978) (156)
- Composition of the myosin light chain kinase from chicken gizzard. (1977) (154)
- Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1. (2008) (153)
- Effects of modulators of myosin light-chain kinase activity in single smooth muscle cells (1989) (145)
- X-ray structure determination of telokin, the C-terminal domain of myosin light chain kinase, at 2.8 A resolution. (1992) (140)
- Effects of Ca2+ on the conformation and enzymatic activity of smooth muscle myosin. (1985) (139)
- The effect of phosphorylation of gizzard myosin on actin activation. (1976) (137)
- Effects of phosphorylation of light chain residues threonine 18 and serine 19 on the properties and conformation of smooth muscle myosin. (1988) (133)
- A relationship between Ca2+ sensitivity and phosphorylation of gizzard actomyosin. (1976) (124)
- Proteolysis of smooth muscle myosin by Staphylococcus aureus protease: preparation of heavy meromyosin and subfragment 1 with intact 20 000-dalton light chains. (1985) (124)
- Autoregulation of enzymes by pseudosubstrate prototopes: myosin light chain kinase. (1988) (123)
- The preparation of tropomyosin and troponin from natural actomyosin. (1969) (114)
- Phosphorylation of smooth muscle myosin: evidence for cooperativity between the myosin heads. (1981) (111)
- Fractionation of troponin into two distinct proteins. (1968) (107)
- Myosin phosphatase: subunits and interactions. (1998) (106)
- Interactions of the Subunits of Smooth Muscle Myosin Phosphatase* (1997) (104)
- The contractile proteins of smooth muscle. Properties and components of a Ca2+-sensitive actomyosin from chicken gizzard. (1975) (104)
- Thiophosphorylation of the 130-kDa Subunit Is Associated with a Decreased Activity of Myosin Light Chain Phosphatase in α-Toxin-permeabilized Smooth Muscle (*) (1995) (102)
- Differential Association and Localization of Myosin Phosphatase Subunits During Agonist-Induced Signal Transduction in Smooth Muscle (2002) (102)
- Proteolysis of smooth muscle myosin light chain kinase. Formation of inactive and calmodulin-independent fragments. (1987) (101)
- Myotonic dystrophy protein kinase phosphorylates the myosin phosphatase targeting subunit and inhibits myosin phosphatase activity (2001) (96)
- Integrin-linked kinase phosphorylates the myosin phosphatase target subunit at the inhibitory site in platelet cytoskeleton. (2002) (94)
- Calyculin-A increases the level of protein phosphorylation and changes the shape of 3T3 fibroblasts. (1991) (93)
- Phosphorylation of a twitchin-related protein controls catch and calcium sensitivity of force production in invertebrate smooth muscle. (1998) (91)
- Identification in turkey gizzard of an acidic protein related to the C-terminal portion of smooth muscle myosin light chain kinase. (1989) (90)
- Correlation of enzymatic properties and conformation of smooth muscle myosin. (1983) (90)
- Arachidonic acid-induced Ca2+ sensitization of smooth muscle contraction through activation of Rho-kinase (2001) (89)
- Smooth Muscle Myosin Phosphatase-associated Kinase Induces Ca2+ Sensitization via Myosin Phosphatase Inhibition* (2002) (87)
- Phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by protein kinase N. (2000) (85)
- Interactions and properties of smooth muscle myosin phosphatase. (1996) (84)
- A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mapping. (1998) (82)
- Calcium-independent myosin light chain kinase of smooth muscle. Preparation by limited chymotryptic digestion of the calcium ion dependent enzyme, purification, and characterization. (1982) (81)
- Phosphorylation-dependent activated tension in skinned gizzard muscle fibers in the absence of Ca2+. (1982) (78)
- Calcium binding by the troponin complex, and the purification and properties of troponin A. (1971) (75)
- Study of the subunit interactions in myosin phosphatase by surface plasmon resonance. (2000) (73)
- Ca2+ and Mg2+ dependent conformations of troponin C as determined by 1H and 19F nuclear magnetic resonance. (1977) (69)
- THE EFFECT OF VARIOUS PROTEIN FRACTIONS ON Z- AND M-LINE RECONSTITUTION (1969) (68)
- Activation of Myosin Phosphatase Targeting Subunit by Mitosis-specific Phosphorylation (1999) (65)
- A novel protein phosphatase inhibitor, tautomycin Effect on smooth muscle (1991) (65)
- Interaction of protein phosphatase type 1 with a splicing factor (1996) (65)
- Interaction of smooth muscle myosin phosphatase with phospholipids. (1997) (64)
- Differential localization of myosin and myosin phosphatase subunits in smooth muscle cells and migrating fibroblasts. (1997) (60)
- Ordered phosphorylation of the two 20 000 molecular weight light chains of smooth muscle myosin. (1983) (60)
- The binding of smooth muscle myosin light chain kinase to actin. (1982) (59)
- Calcium-sensitive regulation of actin-myosin interactions in baby hamster kidney (BHK-21) cells. (1979) (59)
- The adeonosine-triphosphatase activity of desensitized actomyosin. (1967) (59)
- Unphosphorylated twitchin forms a complex with actin and myosin that may contribute to tension maintenance in catch (2007) (57)
- A regulatory subunit of smooth muscle myosin bound phosphatase. (1994) (57)
- Interaction of the Ribosomal Protein, L5, with Protein Phosphatase Type 1 (*) (1995) (56)
- Phosphorylation of a high molecular weight (∼600 kDa) protein regulates catch in invertebrate smooth muscle (1997) (52)
- Smooth muscle myosin light chain kinase. (1983) (52)
- Bovine stomach myosin light chain kinase: purification, characterization, and comparison with the turkey gizzard enzyme. (1982) (51)
- Interaction of myosin phosphatase target subunit 1 with the catalytic subunit of type 1 protein phosphatase. (1998) (51)
- Calmodulin antagonists and cellular physiology (1985) (51)
- Effects of magnesium chloride on smooth muscle actomyosin adenosine-5'-triphosphatase activity, myosin conformation, and tension development in glycerinated smooth muscle fibers. (1984) (51)
- Intracellular calcium and smooth muscle contraction. (1986) (50)
- Endothall thioanhydride inhibits protein phosphatases-1 and -2A in vivo. (1995) (49)
- Okadaic acid induces phosphorylation and translocation of myosin phosphatase target subunit 1 influencing myosin phosphorylation, stress fiber assembly and cell migration in HepG2 cells. (2005) (49)
- Phosphorylation of protein phosphatase type-1 inhibitory proteins by integrin-linked kinase and cyclic nucleotide-dependent protein kinases. (2003) (48)
- Studies on troponin. (1969) (48)
- REMOVAL AND RECONSTITUTION OF Z-LINE MATERIAL IN A STRIATED MUSCLE (1967) (47)
- Actin-binding peptide from smooth muscle myosin light chain kinase. (1993) (47)
- Twitchin from Molluscan Catch Muscle (2003) (47)
- BHK21 myosin: isolation, biochemical characterization and intracellular localization. (1978) (45)
- Characterization and function of MYPT2, a target subunit of myosin phosphatase in heart. (2006) (45)
- Definition of the inhibitory domain of smooth muscle myosin light chain kinase by site-directed mutagenesis. (1991) (45)
- Biochemical basis for contraction of vascular smooth muscle. (1980) (45)
- Effects of Ca2+, Mg2+, and myosin phosphorylation on skinned smooth muscle fibers. (1987) (44)
- Twitchin as a regulator of catch contraction in molluscan smooth muscle (2006) (44)
- Conformation-dependent proteolysis of smooth-muscle myosin. (1984) (43)
- The effect of temperature on actomyosin. (1972) (41)
- Phosphorylation of molluscan twitchin by the cAMP-dependent protein kinase. (2001) (40)
- Paramyosin and the catch mechanism. (1990) (40)
- Urocortin-Induced Decrease in Ca2+ Sensitivity of Contraction in Mouse Tail Arteries Is Attributable to cAMP-Dependent Dephosphorylation of MYPT1 and Activation of Myosin Light Chain Phosphatase (2006) (40)
- Separation and recombination of the ethylene glycol bis (beta-aminoethyl ether)-N,N'-tetraacetic acid-sensitizing factor obtained from a low ionic strength extract of natural actomyosin. (1967) (39)
- The subunit structure of myosin. I. Polydispersity in 5 M guanidine. (1966) (39)
- Effect of phosphorylation on the actin-activated ATPase activity of myosin. (1981) (38)
- Interactions of protein phosphatase type 1, with a focus on myosin phosphatase (2004) (37)
- Phosphorylation of smooth muscle myosin and myosin light chains. (1980) (37)
- Localization of myosin phosphatase target subunit 1 in rat brain and in primary cultures of neuronal cells (2004) (37)
- The targeted disruption of the MYPT1 gene results in embryonic lethality (2005) (37)
- Identification of human CPI-17, an inhibitory phosphoprotein for myosin phosphatase. (2001) (37)
- Studies on the Subunit Composition of Troponin (1973) (36)
- Changes in the cytoskeletal structure of cultured smooth muscle cells induced by calyculin-A. (1993) (36)
- Expression, subcellular localization, and cloning of the 130-kDa regulatory subunit of myosin phosphatase in porcine aortic endothelial cells. (1999) (34)
- Chapter 7 – Actomyosin of Smooth Muscle (1982) (34)
- The myosin cross-bridge cycle and its control by twitchin phosphorylation in catch muscle. (2001) (34)
- Overexpression of myosin phosphatase reduces Ca(2+) sensitivity of contraction and impairs cardiac function. (2010) (31)
- Localization of Myosin Phosphatase Target Subunit and its Mutants (2005) (31)
- Proteolysis and actin-binding properties of 10S and 6S smooth muscle myosin: identification of a site protected from proteolysis in the 10S conformation and by the binding of actin. (1986) (30)
- Identification and localization of myosin phosphatase in human platelets. (1998) (29)
- Gizzard Ca2+-independent myosin light chain kinase: evidence in favor of the phosphorylation theory. (1983) (29)
- The mechanism of inhibition of the actin-activated myosin MgATPase by calponin. (1992) (28)
- Cleavage of a smooth muscle myosin heavy chain near its C terminus by alpha-chymotrypsin. Effect on the properties of myosin. (1991) (28)
- Myosin phosphatase and myosin phosphorylation in differentiating C2C12 cells (2003) (27)
- Purification and characterization of myosin from bovine thyroid. (1977) (24)
- Phosphorylation of paramyosin. (1989) (24)
- Phosphorylation of myosin as a regulatory mechanism in smooth muscle. (1990) (23)
- Myosin Loop 2 Is Involved in the Formation of a Trimeric Complex of Twitchin, Actin, and Myosin* (2009) (23)
- A protein factor inhibiting the magnesium-activated adenosine triphosphatase of desensitized actomyosin. (1967) (23)
- Phosphorylation of smooth muscle actin by the catalytic subunit of the cAMP-dependent protein kinase. (1981) (21)
- Correlation of enzymatic properties and conformation of bovine erythrocyte myosin. (1989) (20)
- Proteolytic cleavage sites in smooth muscle myosin-light-chain kinase and their relation to structural and regulatory domains. (1991) (20)
- Is smooth muscle myosin a substrate for the cAMP‐dependent protein kinase? (1981) (20)
- STUDIES ON LIVER THREONINE DEHYDROGENASE. (1964) (20)
- Sulfhydryl groups of natural actomyosin essential for the Ca 2+ -sensitive response: location and properties. (1972) (18)
- Phosphorylation of caldesmon (1989) (18)
- Effect of monoclonal antibodies on the properties of smooth muscle myosin. (1989) (18)
- Phosphorylation of a high molecular weight (approximately 600 kDa) protein regulates catch in invertebrate smooth muscle. (1997) (17)
- Evidence for myosin-binding phosphatase in heart myofibrils. (1997) (17)
- Interactions of Desensitized Actomyosin with Tropomyosin, Troponin A, Troponin B, and Polyanions (1970) (17)
- Dephosphorylation of distinct sites on the 20 kDa myosin light chain by smooth muscle myosin phosphatase (1999) (17)
- The effect of tropomyosin on the adenosine triphosphatase activity of desensitized actomyosin. (1967) (17)
- Changes in the cytoskeleton of 3T3 fibroblasts induced by the phosphatase inhibitor, calyculin-A (1992) (16)
- A chromatographic and electrophoretic study of sarcoplasm from adult--and foetal-rabbit muscles. (1962) (16)
- The inhibition of the adenosine triphosphatase activity of the subfragment 1-actin complex by troponin plus tropomoosin, troponin B plus tropomyosin and troponin B. (1970) (16)
- The role of myosin phosphorylation in the contraction-relaxation cycle of smooth muscle (1985) (15)
- ATPase activity and superprecipitation of skeletal muscle actomyosin of frog and rabbit: effect of temperature on calcium sensitivity. (1975) (15)
- DEUTERIUM-HYDROGEN EXCHANGE OF MUSCLE PROTEINS (1965) (15)
- Actin crosslinked with glutaraldehyde: evidence to suggest an active role for actin in the regulatory mechanism. (1976) (15)
- Conversion of a Ca2+-dependent myosin light chain kinase from skeletal muscle to a Ca2+-independent form. (1983) (15)
- Molecular cloning and analysis of the 5'-flanking region of the human MYPT1 gene. (2001) (14)
- Myosin and contractile activity in smooth muscle. (1989) (14)
- Phosphorylation of vimentin in the C-terminal domain after exposure to calyculin-A. (1993) (13)
- Effects of the protein phosphatase inhibitors, tautomycin and calyculin-A, on protein phosphorylation and cytoskeleton of human platelets. (1995) (13)
- New Isoform of Cardiac Myosin Light Chain Kinase and the Role of Cardiac Myosin Phosphorylation in α1-Adrenoceptor Mediated Inotropic Response (2015) (13)
- The importance of sulfhydryl groups for the calcium-sensitive response of natural actomyosin. (1970) (13)
- Reverse reaction of smooth muscle myosin light chain kinase. Formation of ATP from phosphorylated light chain plus ADP. (1986) (12)
- Smooth muscle myosin light chain phosphatase. (1992) (12)
- ENZYMATIC MODIFICATION OF MYOSIN BY DISULFIDE EXCHANGE. (1965) (12)
- Phosphorylation of Myosin and the Regulation of Smooth-Muscle Actomyosin (1982) (11)
- Mutants of smooth muscle myosin light chain kinase at tryptophan 800. (1994) (11)
- Smooth-Muscle Myosin II (2008) (11)
- The reaction of myosin with N-ethylmaleimide in the presence of ADP. (1974) (11)
- Comparison of the reaction of N-ethylmaleimide with myosin and heavy meromyosin subfragment 1. (1973) (10)
- Interaction of smooth muscle tropomyosin and smooth muscle myosin. Effect on the properties of myosin. (1989) (10)
- Regulation of the Contractile Cycle in Smooth Muscle (1995) (10)
- Structure-activity relationship within a series of degradation products of tautomycin. (1996) (9)
- Correlation of intrinsic fluorescence and conformation of smooth muscle myosin. (1983) (9)
- Cloning and characterization of a protein phosphatase type 1-binding subunit from smooth muscle similar to the glycogen-binding subunit of liver. (1997) (8)
- 5 – The Contractile Apparatus of Smooth Muscle and Its Regulation by Calcium (1982) (8)
- Cooperative behavior of smooth muscle myosin. (1982) (8)
- Biochemistry of the Contractile Proteins of Smooth Muscle (2011) (8)
- Isolation and characterization of baby hamster kidney (BHK-21) cell modulator protein. (1979) (8)
- The occurrence of tissue-specific twitchin isoforms in the mussel Mytilus galloprovincialis (2008) (7)
- Sequence and expression of a baculovirus protein with antigenic similarity to telokin. (1994) (7)
- Spin-echo 1H NMR studies of differential mobility in gizzard myosin and its subfragments. (1990) (7)
- CHAPTER 1 – Calmodulin: An Introduction to Biochemical Aspects (1985) (7)
- Molecular structure of a proteolytic fragment of TLP20. (1996) (6)
- Smooth Muscle Myosin Phosphatase (1995) (6)
- Trinitrophenylation of smooth muscle myosin. (1985) (5)
- Myosin Light Chain Phosphatase (Myosin Phosphatase) (2002) (4)
- TheAdenosine-Triphosphatase Activity ofDesensitized Actomyosin (1967) (4)
- Structure-function relationships in smooth muscle myosin light chain kinase. (1991) (3)
- Cleavage at site A, Glu-642 to Ser-643, of the gizzard myosin heavy chain decreases affinity for actin. (1993) (3)
- A Type 2A Protein Phosphatase from Clam Smooth Muscle. Use of 4-Methylumbelliferyl Phosphate as Substrate (1997) (2)
- Crystallization and preliminary analysis of telokin, the C-terminal domain of myosin light chain kinase. (1991) (2)
- Myosin light chain kinase: structure-function relationships. (1992) (1)
- CALMODULIN IN SKELETAL MUSCLE (1983) (1)
- Autoinhibition of Myosin Light Chain Kinase (1995) (1)
- Promoter paper Molecular cloning and analysis of the 5P-£anking region of the human MYPT1 gene 1 (2001) (0)
- Modulators of myosin light chain kinase activity affect both [Ca+2] and contraction in single smooth muscle cells. (1990) (0)
- AND MECHANICAL FUNCTION SITE-SPECIFIC PHOSPHORYLATION RELATIONSHIP BETWEEN PRIMARY STRUCTURE AND Twitchin from Molluscan Catch Muscle: Mechanisms of Signal Transduction: (2014) (0)
- CHAPTER 6 SMOOTH-MUSCLE MYOSIN II (2007) (0)
- 213 EFFECTS OF A NOVEL ANTIBIOTIC, TAUTOMYCIN, ON PHOSPHATASE ACTIVITY AND SMOOTH MUSCLE CONTRACTION (1991) (0)
- Tribute to Emil Bozler: frontiers in smooth muscle research, Emil Bozler international symposium (1989) (0)
- Phosphorylation and Atpase Activity of Smooth Muscle Myosin (1982) (0)
- Myosin Light Chain Kinase (2002) (0)
- Erratum: Calcium-sensitive regulation of actin-myosin interactions in baby hamster kidney (BHK-21) cells (Proceedings of the National Academy of Sciences of the United States of America (1979) 76 (184-188)) (1979) (0)
- Obituary: Andrew P. Somlyo (1930–2004) (2004) (0)
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