Dick K. F. Meijer

Dick K. F. Meijer's AcademicInfluence.com Rankings

Dick K. F. Meijer

Medical

#2702

World Rank

#3133

Historical Rank

Pharmacology

#295

World Rank

#344

Historical Rank

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Medical

Dick K. F. Meijer's Degrees

PhD Pharmacology University of Amsterdam
Masters Pharmacy University of Groningen

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Dick K. F. Meijer's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine. (1997) (898)
Abstracts of papers (2005) (816)
Antiviral activities of lactoferrin. (2001) (423)
Antiviral effects of plasma and milk proteins: lactoferrin shows potent activity against both human immunodeficiency virus and human cytomegalovirus replication in vitro. (1995) (371)
MW/Pharm, an integrated software package for drug dosage regimen calculation and therapeutic drug monitoring. (1992) (337)
Substantial excretion of digoxin via the intestinal mucosa and prevention of long‐term digoxin accumulation in the brain by the mdrla P‐glycoprotein (1996) (304)
Up‐regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down‐regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver (1998) (255)
Hepatic uptake of the magnetic resonance imaging contrast agent gadoxetate by the organic anion transporting polypeptide Oatp1. (1999) (225)
Dephosphorylation of endotoxin by alkaline phosphatase in vivo. (1997) (187)
Removal of Phosphate from Lipid A as a Strategy to Detoxify Lipopolysaccharide (2002) (186)
LPS-induced downregulation of MRP2 and BSEP in human liver is due to a posttranscriptional process. (2004) (180)
Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3 (2001) (179)
A physiologic function for alkaline phosphatase: endotoxin detoxification. (1997) (169)
Albumin modified with mannose 6‐phosphate: A potential carrier for selective delivery of antifibrotic drugs to rat and human hepatic stellate cells (1999) (158)
Successful Targeting to Rat Hepatic Stellate Cells Using Albumin Modified with Cyclic Peptides That Recognize the Collagen Type VI Receptor* (2000) (150)
Preparation and functional evaluation of RGD-modified proteins as alpha(v)beta(3) integrin directed therapeutics. (2002) (148)
Synergistic Fungistatic Effects of Lactoferrin in Combination with Antifungal Drugs against ClinicalCandida Isolates (1999) (147)
Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver. (1998) (145)
Antiviral effects of milk proteins: acylation results in polyanionic compounds with potent activity against human immunodeficiency virus types 1 and 2 in vitro. (1996) (139)
A novel strategy to modify adenovirus tropism and enhance transgene delivery to activated vascular endothelial cells in vitro and in vivo. (2004) (133)
Massive targeting of liposomes, surface-modified with anionized albumins, to hepatic endothelial cells. (1997) (125)
Autoradiographic and kinetic demonstration of acinar heterogeneity of taurocholate transport. (1982) (116)
[11] Isolated perfused rat liver technique (1981) (113)
The preferential homing of a platelet derived growth factor receptor-recognizing macromolecule to fibroblast-like cells in fibrotic tissue. (2003) (108)
The Effect of Parenterally Administered Cyclodextrins on Cholesterol Levels in the Rat (2004) (107)
Drug traffic in the hepatobiliary system. (1996) (106)
Targeting dexamethasone to Kupffer cells: Effects on liver inflammation and fibrosis in rats (2001) (104)
Rat liver slices as a tool to study LPS-induced inflammatory response in the liver. (2001) (104)
Comparison of "type I" and "type II" organic cation transport by organic cation transporters and organic anion-transporting polypeptides. (2001) (101)
Mrp2 is essential for estradiol‐17β(β‐D ‐glucuronide)–induced cholestasis in rats (2000) (101)
The Fate of Pancuronium Bromide in Man (1973) (98)
Liver slices in in vitro pharmacotoxicology with special reference to the use of human liver tissue. (1997) (98)
Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations. (1999) (96)
Precision-cut liver slices as a new model to study toxicity-induced hepatic stellate cell activation in a physiologic milieu. (2005) (96)
Hepatobiliary and intestinal clearance of amphiphilic cationic drugs in mice in which both mdr1a and mdr1b genes have been disrupted (1998) (94)
Effect of human liver source on the functionality of isolated hepatocytes and liver slices. (1998) (90)
Targeting hepatic stellate cells for cell-specific treatment of liver fibrosis. (2002) (90)
Characterization of the anti-HIV effects of native lactoferrin and other milk proteins and protein-derived peptides. (2002) (89)
Hepatic endocytosis of various types of mannose-terminated albumins. What is important, sugar recognition, net charge, or the combination of these features. (1990) (88)
Fluorimetric and chromatographic determination of pancuronium bromide and its metabolites in biological materials. (1973) (87)
On the role and fate of LPS-dephosphorylating activity in the rat liver. (2006) (85)
Liver fibrosis in vitro: cell culture models and precision-cut liver slices. (2007) (85)
Contribution of the murine mdr1a P‐glycoprotein to hepatobiliary and intestinal elimination of cationic drugs as measured in mice with an mdr1a gene disruption (1998) (85)
Characteristics of the hepatic stellate cell-selective carrier mannose 6-phosphate modified albumin (M6P(28)-HSA). (2001) (84)
Lactoferrin. Antiviral activity of lactoferrin. (1998) (82)
Targeting of RGD‐modified proteins to tumor vasculature: A pharmacokinetic and cellular distribution study (2002) (82)
In Vitro Cellular Handling and in Vivo Targeting of E-Selectin-Directed Immunoconjugates and Immunoliposomes Used for Drug Delivery to Inflamed Endothelium (2004) (77)
Local Inhibition of Liver Fibrosis by Specific Delivery of a Platelet-Derived Growth Factor Kinase Inhibitor to Hepatic Stellate Cells (2007) (74)
The applicability of rat and human liver slices to the study of mechanisms of hepatic drug uptake. (2001) (72)
Targeting of drugs to the liver. (1995) (71)
Inhibition of cytomegalovirus infection by lactoferrin in vitro and in vivo. (2004) (71)
Inhibition of renal rho kinase attenuates ischemia/reperfusion-induced injury. (2008) (70)
Characterization of transport in isolated human hepatocytes. A study with the bile acid taurocholic acid, the uncharged ouabain and the organic cations vecuronium and rocuronium. (1994) (70)
Hepatobiliary elimination of cationic drugs: The role of P-glycoproteins and other ATP-dependent transporters (1997) (70)
Endothelial cells internalize and degrade RGD-modified proteins developed for tumor vasculature targeting. (2002) (69)
Sodium ion-coupled uptake of taurocholate by rat-liver plasma membrane vesicles. (2008) (69)
Function and regulation of ATP-binding cassette transport proteins involved in hepatobiliary transport. (2001) (67)
Selective Intracellular Delivery of Dexamethasone into Activated Endothelial Cells Using an E-Selectin-Directed Immunoconjugate (2002) (66)
Metabolism of three pharmacologically active drugs in isolated human and rat hepatocytes: analysis of interspecies variability and comparison with metabolism in vivo. (1994) (65)
Potent in vitro anti-human immunodeficiency virus-1 activity of modified human serum albumins. (1991) (65)
A new technique for preparing precision-cut slices from small intestine and colon for drug biotransformation studies. (2005) (64)
CHARACTERIZATION OF RAT SMALL INTESTINAL AND COLON PRECISION-CUT SLICES AS AN IN VITRO SYSTEM FOR DRUG METABOLISM AND INDUCTION STUDIES (2005) (64)
Intracellular Delivery of the p38 Mitogen-Activated Protein Kinase Inhibitor SB202190 [4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole] in Renal Tubular Cells: A Novel Strategy to Treat Renal Fibrosis (2006) (63)
Pharmacokinetics of biliary excretion in man. VI. Indocyanine green (2004) (63)
Dexamethasone coupled to albumin is selectively taken up by rat nonparenchymal liver cells and attenuates LPS-induced activation of hepatic cells. (2000) (62)
Antiviral activity of human lactoferrin: inhibition of alphavirus interaction with heparan sulfate. (2005) (61)
The Antiproliferative Drug Doxorubicin Inhibits Liver Fibrosis in Bile Duct-Ligated Rats and Can Be Selectively Delivered to Hepatic Stellate Cells in Vivo (2006) (59)
Selective targeting of pentoxifylline to hepatic stellate cells using a novel platinum-based linker technology. (2006) (59)
Preparation and characterization of conjugates of (modified) human serum albumin and liposomes: drug carriers with an intrinsic anti-HIV activity. (1996) (58)
Novel, negatively charged, human serum albumins display potent and selective in vitro anti-human immunodeficiency virus type 1 activity. (1993) (58)
Drug targeting systems for antiviral agents: options and limitations. (1992) (58)
Interactions between P‐glycoprotein substrates and other cationic drugs at the hepatic excretory level (1998) (58)
Bioanalysis of captopril: two sensitive high-performance liquid chromatographic methods with pre- or postcolumn fluorescent labeling. (1997) (57)
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) induce hepatic expression of the phospholipid translocase mdr2 in rats. (1999) (56)
Drug-targeting to the kidney: renal delivery and degradation of a naproxen-lysozyme conjugate in vivo. (1997) (56)
Interaction of targeted liposomes with primary cultured hepatic stellate cells: Involvement of multiple receptor systems. (2006) (56)
Hepatic drug transport in the rat. A comparison between isolated hepatocytes, the isolated perfused liver and the liver in vivo. (1982) (56)
Gliotoxin non‐selectively induces apoptosis in fibrotic and normal livers (2006) (55)
Transport of dibromosulphthalein by isolated rat hepatocytes. (1981) (55)
The Pharmacokinetics of β-Cyclodextrin and Hydroxypropyl-β-cyclodextrin in the Rat (1990) (54)
Hepatic and intrahepatic targeting of an anti-inflammatory agent with human serum albumin and neoglycoproteins as carrier molecules. (1993) (53)
A rapid and simple method for cryopreservation of human liver slices. (1998) (51)
Formaldehyde treated albumin contains monomeric and polymeric forms that are differently cleared by endothelial and Kupffer cells of the liver: evidence for scavenger receptor heterogeneity. (1991) (51)
Tumor vasculature targeted therapies: getting the players organized. (1998) (50)
Antispasmodic effects of valeriana compounds: an in-vivo and in-vitro study on the guinea-pig ileum. (1982) (49)
Hepatic uptake and biliary excretion of dibromosulphthalein. Albumin dependence, influence of phenobarbital and nafenopin pretreatment and the role of y and z protein. (1977) (48)
Liver slices as a model to study fibrogenesis and test the effects of anti-fibrotic drugs on fibrogenic cells in human liver. (2008) (48)
Specific Drug Delivery to the Kidney (2002) (48)
Effect of hypolipidemic drugs, nafenopin and clofibrate, on the concentration of ligandin and Z protein in rat liver. (1975) (47)
Studies on the targeted delivery of the antifibrogenic compound mycophenolic acid to the hepatic stellate cell. (2005) (47)
Cell-specific Delivery of a Transforming Growth Factor-beta Type I Receptor Kinase Inhibitor to Proximal Tubular Cells for the Treatment of Renal Fibrosis (2008) (46)
Viral Load in Breast Milk Correlates with Transmission of Human Cytomegalovirus to Preterm Neonates, but Lactoferrin Concentrations Do Not (2001) (46)
Charge modification of plasma and milk proteins results in antiviral active compounds (1999) (46)
Relationship between chemical structure and physicochemical properties of series of bulky organic cations and their hepatic uptake and biliary excretion rates. (1997) (45)
Pharmacokinetics and In Vivo Gene Transfer of Plasmid DNA Complexed with Mannosylated Poly(L-Lysine) in Mice (2000) (45)
Mechanisms for the hepatic uptake of organic cations. Studies with the muscle relaxant vecuronium in isolated rat hepatocytes. (1988) (45)
Effects of a New Bioactive Lipid-Based Drug Carrier on Cultured Hepatic Stellate Cells and Liver Fibrosis in Bile Duct-Ligated Rats (2007) (44)
Heterologous expression of various P-glycoproteins in polarized epithelial cells induces directional transport of small (type 1) and bulky (type 2) cationic drugs. (1998) (44)
A multispecific uptake system for taurocholate, cardiac glycosides and cationic drugs in the liver. (1992) (44)
Pharmacokinetic and Biodistribution Profile of Recombinant Human Interleukin-10 Following Intravenous Administration in Rats with Extensive Liver Fibrosis (2004) (43)
Stereoselective transport of hydrophilic quaternary drugs by human MDR1 and rat Mdr1b P‐glycoproteins (2002) (43)
Covalent and Noncovalent Protein Binding of Drugs: Implications for Hepatic Clearance, Storage, and Cell-Specific Drug Delivery (1989) (42)
Drug Targeting: Organ-Specific Strategies (2001) (42)
Plasma lactoferrin levels are decreased in end-stage AIDS patients. (1999) (41)
Collection of metabolites in bile and urine from the rat. (1981) (41)
Differential effects of metabolic inhibitors on cellular and mitochondrial uptake of organic cations in rat liver. (1993) (41)
Human liver slices as an in vitro model to study toxicity-induced hepatic stellate cell activation in a multicellular milieu. (2006) (41)
A novel lipid-based drug carrier targeted to the non-parenchymal cells, including hepatic stellate cells, in the fibrotic livers of bile duct ligated rats. (2007) (40)
Specific delivery of captopril to the kidney with the prodrug captopril-lysozyme. (1999) (40)
Carrier-mediated transport in the hepatic distribution and elimination of drugs, with special reference to the category of organic cations (1990) (40)
Hepatic uptake and biliary excretion of organic cations--I. Characterization of three new model compounds. (1984) (40)
Drug targeting to the liver with lactosylated albumins: Does the glycoprotein target the drug or is the drug targeting the glycoprotein? (1986) (39)
The Effects of Cyclodextrins on the Disposition of Intravenously Injected Drugs in the Rat (1991) (39)
Precision-cut fibrotic rat liver slices as a new model to test the effects of anti-fibrotic drugs in vitro. (2006) (39)
Influence of bile salts on hepatic transport of dibromosulphthalein. (1979) (38)
Effect of cold and warm ischaemia on drug metabolism in isolated hepatocytes and slices from human and monkey liver. (1998) (38)
Pharmacokinetics and cardiovascular dynamics of pipecuronium bromide during coronary artery surgery (1990) (38)
Mechanism of anti-HIV activity of negatively charged albumins: biomolecular interaction with the HIV-1 envelope protein gp120. (1996) (38)
Preparation and Functional Evaluation of RGD-Modified Proteins as r v â 3 Integrin Directed Therapeutics (38)
Neoglycoproteins as carriers for antiviral drugs: synthesis and analysis of protein-drug conjugates. (1991) (37)
Curare-like agents: relation between lipid solubility and transport into bile in perfused rat liver. (1970) (37)
Pharmacokinetics of biliary excretion in man V (1983) (37)
Current concepts on hepatic transport of drugs. (1987) (37)
Isolated perfused rat liver technique. (1981) (36)
TARGETING OF DRUGS TO VARIOUS BLOOD-CELL TYPES USING (NEO-)GLYCOPROTEINS, ANTIBODIES AND OTHER PROTEIN CARRIERS (1994) (36)
Mechanisms for the uptake of cationic drugs by the liver: a study with tributylmethylammonium (TBuMA). (1991) (36)
Targeting of antiviral drugs to T4-lymphocytes. Anti-HIV activity of neoglycoprotein-AZTMP conjugates in vitro. (1990) (36)
Targeting of sugar- and charge-modified albumins to fibrotic rat livers: the accessibility of hepatic cells after chronic bile duct ligation. (1998) (35)
Tumor Vascular Endothelium: Barrier or Target in Tumor Directed Drug Delivery and Immunotherapy (2004) (35)
Quantification of renal low-molecular-weight protein handling in the intact rat. (1993) (35)
Sequestration of organic cations by acidified hepatic endocytic vesicles and implications for biliary excretion. (1992) (34)
Hepatic transport of mono and bisquaternary ammonium compounds (1970) (34)
Mrp2 is essential for estradiol-17beta(beta-D-glucuronide)-induced cholestasis in rats. (2000) (33)
Hepatic uptake and biliary excretion of d-tubocurarine and trimethyltubocurarine in the rat in vivo and in isolated perfused rat livers. (1976) (33)
Delivery of viral vectors to hepatic stellate cells in fibrotic livers using HVJ envelopes fused with targeted liposomes (2007) (33)
Secretion of the organic anion harmol sulfate from liver into blood. Evidence for a carrier-mediated mechanism. (1985) (32)
Dissemination of Rat Cytomegalovirus through Infected Granulocytes and Monocytes In Vitro and In Vivo (2003) (31)
IN VITRO AND EX VIVO TEST SYSTEMS TO RATIONALIZE DRUG DESIGN AND DELIVERY (1994) (31)
Hepatocyte heterogeneity in bile formation and hepatobiliary transport of drugs. (1992) (31)
Comparative pharmacokinetics of d-tubocurarine and metocurine in man. (1979) (31)
Structure-pharmacokinetics relationship of quaternary ammonium compounds (1984) (31)
Design and Fungicidal Activity of Mucoadhesive Lactoferrin Tablets for the Treatment of Oropharyngeal Candidosis (2002) (31)
Characterization of the uptake of rocuronium and digoxin in human hepatocytes: carrier specificity and comparison with in vivo data. (1998) (30)
The Fate of Pancuronium Bromide in the Cat (1973) (30)
Influence of 48 hours of cold storage in University of Wisconsin organ preservation solution on metabolic capacity of rat hepatocytes. (1997) (30)
POTENTIALS AND LIMITATIONS OF THE LOW-MOLECULAR-WEIGHT PROTEIN LYSOZYME AS A CARRIER FOR RENAL DRUG TARGETING (2001) (30)
Transport mechanisms for cationic drugs and proteins in kidney, liver and intestine: implication for drug interactions and cell-specific drug delivery. (1999) (29)
Homing of negatively charged albumins to the lymphatic system: general implications for drug targeting to peripheral tissues and viral reservoirs. (1999) (29)
Lactosylation of albumin reduces uptake rate of dibromosulfophthalein in perfused rat liver and dissociation rate from albumin In Vitro (1987) (29)
Cell-Specific Targeting of Lipid-Based Carriers for ODN and DNA (2005) (29)
Cellular Handling of a Dexamethasone-Anti-E-Selectin Immunoconjugate by Activated Endothelial Cells: Comparison with Free Dexamethasone (2002) (28)
CD3 directed bispecific antibodies induce increased lymphocyte–endothelial cell interactions in vitro (2000) (28)
Delivery of pharmacologically active dexamethasone into activated endothelial cells by dexamethasone-anti-E-selectin immunoconjugate. (2003) (28)
Binding of drugs with a quaternary ammonium group to alpha-1 acid glycoprotein and asialo alpha-1 acid glycoprotein. (1985) (27)
Human Liver Slices Express the Same Lidocaine Biotransformation Rate as Isolated Human Hepatocytes (1993) (27)
The influence of various bile salts and some cholephilic dyes on Na+- and Mg2+-activated ATPase of rat liver in relation to cholestatic effects. (1978) (26)
The Pharmacokinetic and Biological Activity Profile of Dexamethasone Targeted to Sinusoidal Endothelial and Kupffer Cells (2003) (25)
Low Molecular Weight Proteins as Carriers for Renal Drug Targeting: Naproxen–Lysozyme (1991) (25)
The influence of dehydrocholate on hepatic uptake and biliary excretion of 3H-taurocholate and 3H-ouabain. (1976) (25)
Inhibition of influenza virus fusion by polyanionic proteins. (1997) (24)
Synergy of bovine lactoferrin with the anti-cytomegalovirus drug cidofovir in vitro. (2003) (24)
Mechanisms underlying the prolonged duration of action of muscle relaxants caused by extrahepatic cholestasis. (1981) (23)
RENAL-SELECTIVE DELIVERY AND ANGIOTENSIN-CONVERTING ENZYME INHIBITION BY SUBCUTANEOUSLY ADMINISTERED CAPTOPRIL-LYSOZYME (2005) (23)
Stabilized Lipid Coated Lipoplexes for the Delivery of Antisense Oligonucleotides to Liver Endothelial Cells In Vitro and In Vivo (2004) (23)
Mechanisms for the Hepatic Clearance of Oligopeptides and Proteins (1993) (23)
Low-molecular-weight proteins as carriers for renal drug targeting. (1993) (23)
Heterogeneous acinar localization of the asialoglycoprotein internalization system in rat hepatocytes (1988) (23)
Hepatobiliary transport of drugs: do periportal and perivenous hepatocytes perform the same job? (1985) (22)
Drug targeting to the kidney with low-molecular-weight proteins (1994) (22)
Uptake and Excretion of Vecuronium Bromide and Pancuronium Bromide in the Isolated Perfused Rat Liver (1988) (22)
Mechanisms for the hepatic uptake and biliary excretion of tributylmethylammonium: studies with rat liver plasma membrane vesicles. (1996) (22)
Hepatic and renal disposition of pancuronium and gallamine in patients with extrahepatic cholestasis. (1981) (22)
The use of bispecific antibodies in tumor cell and tumor vasculature directed immunotherapy. (2000) (22)
Measurement of the association of cholephylic organic anions with different binding proteins. (1985) (22)
(Glyco)-protein drug carriers with an intrinsic therapeutic activity : The concept of dual targeting (1996) (21)
Comparative Pharmacokinetics of d‐Tubocurarine and Metocurine in Man (1979) (21)
Studies on the Mechanism of Binding and Uptake of Immune Complexes by Various Cell Types of Rat Liver in Vivo (1986) (21)
The role of the liver in clearance of glycoproteins from the general circulation, with special reference to intestinal alkaline phosphatase (1982) (20)
Low Molecular Weight Proteins as Carriers for Renal Drug Targeting: Naproxen Coupled to Lysozyme via the Spacer L-Lactic Acid (1993) (20)
NEGATIVELY CHARGED ALBUMINS: A NOVEL CLASS OF POLYANIONIC PROTEINS WITH A POTENT ANTI-HIV-I ACTIVITY (1994) (20)
Development of vasculature targeting strategies for the treatment of cancer and chronic inflammatory diseases. (2002) (20)
Hepatic transport mechanisms for bivalent organic cations. Subcellular distribution and hepato-biliary concentration gradients of some steroidal muscle relaxants. (1990) (19)
Renal specific delivery of sulfamethoxazole in the rat by coupling to the low molecular weight protein lysozyme via an acid-sensitive linker (1992) (19)
Vesicular uptake system for the cation lucigenin in the rat hepatocyte. (1989) (19)
Distribution and Elimination of the Glycosidase Inhibitors 1-Deoxymannojirimycin and N-Methyl-1-Deoxynojirimycin in the Rat in Vivo (1992) (19)
Acinar heterogeneity in hepatic transport of dibromosulfophthalein and ouabain studied by autoradiography, normal and retrograde perfusions and computer simulation. (1983) (19)
Vascular Endothelium in Inflamed Tissue as a Target for Site Selective Delivery of Drugs (2001) (18)
Massive and Selective Delivery of Lipid-Coated Cationic Lipoplexes of Oligonucleotides Targeted in Vivo to Hepatic Endothelial Cells (2002) (18)
Resistance of the human immunodeficiency virus to the inhibitory action of negatively charged albumins on virus binding to CD4. (1999) (18)
The influence of binding to albumin and α1-acid glycoprotein on the clearance of drugs by the liver (1987) (18)
Analysis of in vitro lymphocyte adhesion and transendothelial migration by fluorescent-beads-based flow cytometric cell counting. (1998) (18)
Mechanism of anti-HIV activity of succinylated human serum albumin. (1999) (18)
alpha-Bromoisovalerylurea as model substrate for studies on pharmacokinetics of glutathione conjugation in the rat. II. Pharmacokinetics and stereoselectivity of metabolism and excretion in vivo and in the perfused liver. (1986) (18)
The cardiac glycoside sensitive step in the hepatic transport of the bisquaternary ammonium compound, hexafluorenium. (1971) (18)
Targeting of Doxorubicin to the Urinary Bladder of the Rat Shows Increased Cytotoxicity in the Bladder Urine Combined With An Absence of Renal Toxicity (2002) (18)
Comparison of human hepatocytes isolated from livers accepted or discarded for orthotopic transplantation. (1995) (17)
Rectal versus oral absorption of codeine phosphate in man. (1983) (17)
Targeting naproxen coupled to human serum albumin to nonparenchymal cells reduces endotoxin‐induced mortality in rats with biliary cirrhosis (1997) (17)
CHOLESTASIS AND MUSCLE-RELAXANTS (1980) (17)
Disease-induced drug targeting using novel peptide-ligand albumins. (2001) (17)
Stereoselective inhibition by the diastereomers quinidine and quinine of uptake of cardiac glycosides into isolated rat hepatocytes. (1998) (17)
Drastic improvement in the rectal absorption profile of morphine in man (2004) (17)
The excretion of hexafluorenium in man and rat. (1971) (17)
Urine collection in the freely moving rat: reliability for measurement of short-term renal effects. (1997) (17)
A kinetic study of hepatic uptake of canine intestinal alkaline phosphatase in the rat. (2008) (17)
Optimization of the reaction conditions for the synthesis of neoglycoprotein-AZT-monophosphate conjugates. (1995) (17)
Structure-pharmacokinetics relationship of quaternary ammonium compounds (1984) (17)
Prediction of the pharmacokinetics of succinylated human serum albumin in man from in vivo disposition data in animals and in vitro liver slice incubations. (2006) (16)
An extended pharmacokinetic/pharmacodynamic model describing quantitatively the influence of plasma protein binding, tissue binding, and receptor binding on the potency and time course of action of drugs (1996) (16)
Biliary excretion of FITC metabolites after administration of FITC labeled asialo orosomucoid as a measure of lysosomal proteolysis. (1985) (16)
Investigations on the hepatic uptake systems for organic cations with a photoaffinity probe of procainamide ethobromide. (1992) (16)
Influence of taurocholate on hepatic clearance and biliary excretion of asialo intestinal alkaline phosphatase in the rat in vivo and in isolated perfused rat liver. (1983) (16)
Simultaneous analysis of azidothymidine and its mono-, di- and triphosphate derivatives in biological fluids, tissue and cultured cells by a rapid high-performance liquid chromatographic method. (1992) (16)
Separation of periportal and perivenous rat hepatocytes by fluorescence‐activated cell sorting: Confirmation with colloidal gold as an exogenous marker (1991) (16)
Pharmacokinetics and anti-HIV-1 efficacy of negatively charged human serum albumins in mice. (1997) (15)
Hepatic uptake and biliary excretion of organic cations--II. The influence of ion pair formation. (1984) (15)
Value of the in vitro or in vivo monoethylglycinexylidide test for predicting liver graft function. (1997) (15)
Effect of nafenopin (SU-13,437) on liver functions. Hepatic uptake and biliary excretion of ouabain in the rat. (1975) (15)
Selective activity of several cholic acid derivatives against human immunodeficiency virus replication in vitro. (1989) (15)
The pharmacokinetics of beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin in the rat. (1990) (15)
Mechanistic aspects of uptake and sinusoidal efflux of dibromosulfophthalein in the isolated perfused rat liver. (1991) (15)
Modulators of the protein kinase C system influence biliary excretion of cationic drugs (1993) (14)
Pharmacokinetics of the hepatic transport of organic anions: Influence of extra- and intracelluar binding on hepatic storage of dibromosulfophthalein and interactions with indocyanine green (1984) (14)
Molecular Mechanisms of the Adsorption of a Model Protein (Human Serum Albumin) on Poly(Methylidene Malonate 2.1.2) Nanoparticles (2004) (14)
Hepatic disposition of cationic drugs bound to asialoorosomucoid: lack of coendocytosis and evidence for intrahepatic dissociation. (1987) (14)
The capability of isolated hepatocytes and liver slices of donor livers to predict graft function after liver transplantation. (2000) (14)
Renal drug delivery with low-molecular-weight proteins : The effect of charge modifications on the body distribution of drug-lysozyme conjugates (1999) (14)
Maintenance of viability and transport function after preservation of isolated rat hepatocytes in various simplified University of Wisconsin solutions. (1993) (14)
The stereoisomers quinine and quinidine exhibit a marked stereoselectivity in the inhibition of hepatobiliary transport of cardiac glycosides. (1998) (13)
The molecular basis for hepatobiliary transport of organic cations and organic anions. (1999) (13)
Renal targeting of a non-steroidal anti-inflammatory drug: effects on renal prostaglandin synthesis in the rat. (1998) (13)
Pharmacokinetic Analysis and Cellular Distribution of the Anti-HIV Compound Succinylated Human Serum Albumin (Suc-HSA) in Vivo and in the Isolated Perfused Rat Liver (1993) (13)
CARRIER-MEDIATED TRANSPORT IN THE HANDLING OF DRUGS BY THE LIVER (1983) (13)
High‐Performance Liquid Chromatographic Assay of Flecainide and Its Enantiomers in Serum (1989) (12)
HEPATIC-UPTAKE AND BILIARY-EXCRETION OF DIBROMOSULFTHALEIN (DBSP) IN RAT AND IN MAN (1980) (12)
Ukrain both as an anti cancer and immunoregulatory agent. (1992) (12)
Effect of Hypothermia on the Hepatic Uptake and Biliary Excretion of Vecuronium in the Isolated Perfused Rat Liver (2001) (12)
Influence of albumin on the net sinusoidal efflux of the organic anion dibromosulfophthalein from rat liver (1992) (12)
Chapter 6 Intracellular Delivery of the p 38 MAPK Inhibitor SB 202190 in Renal Tubular Cells : a Novel Strategy to Treat Renal Fibrosis (2006) (12)
Zonal distribution of the cation lucigenin in rat liver: influence of taurocholate. (1989) (11)
Choleresis and hepatic transport mechanisms (2004) (11)
Pharmacokinetics and whole body distribution of elastase derived angiostatin(k1‐3) in rats (2001) (11)
PHARMACOKINETICS OF BILIARY-EXCRETION IN MAN - PLASMA DISAPPEARANCE OF INDOCYANINE GREEN IN RELATION TO ITS EXCRETION RATE (1984) (11)
Structure-pharmacokinetics relationship of series of aminosteroidal neuromuscular blocking agents in the cat. (2000) (11)
Absorption kinetics of oral and rectal flecainide in healthy subjects (2004) (11)
RGD‐modified anti‐CD3 antibodies redirect cytolytic capacity of cytotoxic T lymphocytes toward αvβ3‐expressing endothelial cells (2004) (11)
Bioanalysis and pharmacokinetics of the p38 MAPkinase inhibitor SB202190 in rats. (2005) (11)
Potent inhibition of replication of primary HIV type 1 isolates in peripheral blood lymphocytes by negatively charged human serum albumins. (1997) (11)
Targeting of stabilized plasmid lipid particles to hepatocytes in vivo by means of coupled lactoferrin (2007) (11)
Anti-HIV-1 activity of combinations and covalent conjugates of negatively charged human serum albumins (NCAs) and AZT. (1999) (11)
A histochemical study on the distribution of injected canine intestinal alkaline phosphatase in rat liver. (2008) (10)
Targeting of naproxen covalently linked to HSA to sinusoidal cell types of the liver. (1998) (10)
Targeting of captopril to the kidney reduces renal angiotensin-converting enzyme activity without affecting systemic blood pressure. (2002) (10)
Distribution of quaternary ammonium compounds between particulate and soluble constituents of rat liver, in relation to their transport from plasma into bile (2004) (10)
Renal targeting of captopril selectively enhances the intrarenal over the systemic effects of ACE inhibition in rats (2002) (10)
Hepatobiliary disposition and targeting of drugs and genes (1999) (10)
The Antiviral Protein Human Lactoferrin Is Distributed in the Body to Cytomegalovirus (CMV) Infection-Prone Cells and Tissues (2004) (10)
Liver Diseases. Biochemical mechanisms and new therapeutic insights. (2006) (10)
The influence of taurocholate and dehydrocholate choleresis on plasma disappearance and biliary excretion of indocyanine green in the rat (2004) (9)
RGD-modified anti-CD3 antibodies redirect cytolytic capacity of cytotoxic T lymphocytes toward alphavbeta3-expressing endothelial cells. (2004) (9)
Pharmacokinetics of steroidal muscle relaxants in isolated perfused rat liver. (1992) (9)
Function and regulation of ATP-binding cassette transport proteins involved in hepatobiliary transport (vol 12, pg 13, 2000) (2001) (9)
The fate of diastereomeric glutathione conjugates of alpha-bromoisovalerylurea in blood in the rat in vivo and in the perfused liver. Stereoselectivity in biliary and urinary excretion. (1991) (9)
Optimized Targeting of Polyethylene Glycol-Stabilized Anti-Intercellular Adhesion Molecule 1 Oligonucleotide/Lipid Particles to Liver Sinusoidal Endothelial Cells (2005) (9)
Pharmacokinetic modeling of the sinusoidal efflux of anionic ligands from the isolated perfused rat liver: The influence of albumin (1993) (8)
Clearance of indometacin occurs predominantly by renal glucuronidation (1992) (8)
The influence of phenobarbital pretreatment on the subcellular distribution in liver and transport rate in isolated hepatocytes of dibromosulfophthalein. (1982) (7)
Drug targeting to the liver with bile acids: THE “trojan horse” resurrected? (1993) (7)
The N-benzyl derivative of the glucosidase inhibitor 1-deoxynojirimycin shows a prolonged half-life and a more complete oral absorption in the rat compared with the N-methyl analog. (1998) (7)
Cellular distribution and handling of liver-targeting preparations in human livers studied by a liver lobe perfusion. (2001) (7)
Bile salts and neuromuscular blocking agents. (1981) (7)
Preliminary study on the absorption profile after rectal and oral administration of methadone in human volunteers (1984) (7)
Heterogeneity of rat hepatocytes in transport and hepatic binding of asialoalkaline phosphatase studied after induction of selective acinar damage by N-hydroxy-2-acetylaminofluorene and carbon tetrachloride. (1983) (7)
Novel therapeutic targets for the treatment of tubulointerstitial fibrosis (2008) (7)
PRESERVATION OF RAT LIVERS AND ISOLATED RAT AND HUMAN HEPATOCYTES IN UW SOLUTION (1989) (7)
On the localisation of d-tubocurarine in rat liver lysosomes in vivo by electron microscopy and subcellular fractionation (2004) (7)
A Phase I/IIa Study with Succinylated Human Serum Albumin (Suc-HSA), a candidate HIV-1 Fusion Inhibitor (2007) (7)
University of Groningen 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors ( statins ) induce hepatic expression of the phospholipid translocase mdr 2 in rats (1999) (7)
Unequal Disposition of Enantiomers of the Organic Cation Oxyphenonium in the Rat Isolated Perfused Liver (1989) (6)
Intracellular Delivery of the P38 MAPK Inhibitor SB202190 in Renal Tubular Cells: a Novel Strategy to Treat Renal Fibrosis (2006) (6)
A study on the buffering activity of the human rectum (1989) (6)
Pharmacokinetics of the oral narcotic analgesic bezitramide and preliminary observations on its effect on experimentally induced pain (2004) (6)
The sinusoidal efflux of dibromosulfophthalein from rat liver is stimulated by albumin, ligandin and fatty acid binding protein but not by other dibromosulfophthalein binding proteins. (1994) (6)
Clinical studies of Ukrain in terminal cancer patients (phase II). (1992) (6)
The Metabolic Fate of the Anti-HIV Active Drug Carrier Succinylated Human Serum Albumin after Intravenous Administration in Rats (2001) (5)
Heterogeneity of rat hepatocytes in bile acid and DBSP transport studied after induction of selective acinar damage by N-hydroxy-2-acetylaminofluorene and carbon tetrachloride (1983) (5)
CORRELATION BETWEEN PHYSICO-CHEMICAL PROPERTIES AND PHARMACOKINETIC AND DYNAMIC PARAMETERS OF MUSCLE RELAXANTS (1992) (5)
Rectal absorption of metronidazol from polyethylene glycol suppositories (1984) (5)
Uptake and excretion of the quaternary ammonium compound deptropine methiodide in the isolated perfused rat liver (2004) (5)
Cell Specific Delivery of Anti‐Inflammatory Drugs to Hepatic Endothelial and Kupffer Cells for the Treatment of Inflammatory Liver Diseases (2001) (5)
HEPATIC TRANSPORT OF ORGANIC CATIONS - INFLUENCE OF BILE-SALT CHOLERESIS (1906) (5)
The influence of charge clustering on the anti-HIV-1 activity and in vivo distribution of negatively charged albumins. (2002) (5)
Oxford Textbook of Clinical Hepatology (1999) (5)
Interactions of cationic drugs and cardiac glycosides at the hepatic uptake level: studies in the ratin vivo, isolated perfused rat liver, isolated rat hepatocytes and oocytes expressing oatp2 (2002) (5)
Effect of nafenopin (SU-13,437) on liver function (2004) (5)
The in vitro anti-HIV efficacy of negatively charged human serum albumin is antagonized by heparin. (1997) (5)
Disposition of Glycosidase Inhibitors in the Isolated Perfused Rat Liver: Hepatobiliary and Subcellular Concentration Gradients of 1-Deoxymannojirimycin and N-Methyl-1-Deoxynojirimycin (2004) (4)
Effect of nafenopin (SU-13, 437) on liver function (2004) (4)
RECTAL ABSORPTION OF METHADONE FROM DISSOLUTION-PROMOTING VEHICLES (1986) (4)
Uptake of taurocholic acid in human hepatocytes isolated from livers of donors of different age. (1998) (4)
Lumen perfusion of the human rectum in situ: a method to study mechanisms for rectal drug transport in humans. (1984) (4)
Manipulation of rectal absorption rate of phenytoin in man (1981) (4)
Synthesis of 4‐Azido‐N‐[2‐(diethylmethylammonium)ethyl]benzamide Iodide: A Photolabile Derivative of Procainamidethobromide (1989) (4)
Localization of d-tubocurarine in rat liver lysosomes (1977) (4)
Delivery of Drugs and Antisense Oligonucleotides to the Proximal Tubular Cell of the Kidney Using Macromolecular and Pro‐drug Approaches (2001) (4)
Contribution of academic research to discovery and development of medicines: current status and future opportunities (2005) (4)
Binding of drugs to alpha 1-acid glycoprotein and its desialylated form. Influence on hepatic disposition and implications for drug targeting to the liver. (1989) (4)
Local inhibition of liver fi brosis by specifi c delivery of a PDGF kinase inhibitor to hepatic stellate cells (2006) (4)
Transport of organic cations by the rat organic anion transporting polypeptides oatp1, oatp2 and the human OATP. (1998) (4)
Structure-pharmacokinetic and pharmacodynamic relationships of steroidal neuromuscular blocking agents (1995) (4)
Quantification of renal low-molecular-weight protein degradation in the intact rat. (1993) (4)
Choleresis and hepatic transport mechanisms (1978) (3)
Renal targeting of captopril using subcutaneous administration of captopril-lysozyme conjugate. (2005) (3)
MECHANISMS FOR THE HEPATIC-UPTAKE AND BILIARY-EXCRETION OF CATIONIC DRUGS (1994) (3)
Transport of organic ions through lipid bilayers (1981) (3)
COUPLING OF THE ANTIVIRAL DRUG ARA-AMP TO LACTOSAMINATED ALBUMIN LEADS TO A CELL-SPECIFIC UPTAKE AND RELEASE IN RAT AND HUMAN HEPATOCYTES (1992) (3)
Antiviral effects of milk proteins: Acylation results in polyanionic compounds with potent activity against HIV type I and II in vitro (1996) (3)
SECRETION OF HARMOL SULFATE FROM LIVER INTO BLOOD - EVIDENCE FOR A CARRIER-MEDIATED MECHANISM (1984) (3)
NONUNIFORMITY IN HEPATIC-UPTAKE MECHANISMS FOR ORGANIC CATIONS (1987) (3)
Determination of the membrane potential in bacterial membrane vesicles from the accumulation of N‐methyldeptropine (1979) (3)
Deuterium Isotope Effect on the Metabolism of the Flame Retardant Tris(2,3-dibromopropyl) Phosphate in the Isolated Perfused Rat Liver (1995) (3)
MULTIPLICITY IN HEPATIC-UPTAKE MECHANISMS FOR ORGANIC CATIONS (1988) (3)
Anti-human cytomegalovirus effects of breast milk - Reply (1996) (3)
Abstracts of papers and posters (2005) (3)
ADVANCES IN LACTOFERRIN RESEARCH (1998) (3)
Isolated perfused liver as a tool to study the disposition of peptides, liver first-pass effects, and cell-specific drug delivery (1997) (3)
Rectal versus oral absorption of diflunisal in man (1984) (3)
Antiviral effects of plasma and milk proteins: Lactoferrin shows potent antiviral activity on both HIV and HCMV replication in vitro in the same concentration range (1996) (3)
Determination of dopaminergic prodrugs by high-performance liquid chromatography followed by post-column ion-pair extraction. (1997) (2)
Limitations on the specificity of targeting asialoglycoprotein-drug conjugates to hepatocytes. (1991) (2)
Transport and Metabolism in the Hepatobiliary System (2011) (2)
Pharmacokinetics of succinylated serum albumin in mice, rats and monkeys: Implications for dosage regimens in the therapy of HIV-infection and anti-HIV efficacy in mice (1997) (2)
The action of flecainide acetate and its enantiomers on mammalian non-myelinated nerve fibres (1989) (2)
HEPATIC TRANSPORT MECHANISMS - INFLUENCE OF CHOLERESIS ON BILIARY-EXCRETION OF ORGANIC-COMPOUNDS (1976) (2)
Tolerance and anti-HIV efficacy of negatively charged albumins in rats, monkeys and HIV-infected mice (1998) (2)
EUFEPS report. Contribution of academic research to discovery and development of medicines: current status and future opportunities. (2005) (2)
Effects of anti-proteinuric therapy with angiotensin-converting-enzyme inhibition on renal protein catabolism in the adriamycin-induced nephrotic rat. (2003) (2)
MECHANISMS FOR HEPATIC UPTAKE AND BILIARY-EXCRETION OF ORGANIC CATIONS - INFLUENCE OF LIPOPHILICITY (1975) (2)
Pharmacokinetics of xamoterol glucuronidation in the rat in vivo and in liver perfusion. (1987) (2)
INTERACTION OF DRUGS AT THE HEPATIC-UPTAKE LEVEL - CARDIAC-GLYCOSIDES AND ORGANIC CATIONS (1988) (2)
The influence of pH on rectal absorption of sodium benzoate studied in man by rectal lumen perfusion (1990) (2)
The development of novel albumin carriers to hepatic stellate cells by application of cyclopeptide moieties recognizing collagen type VI and platelet derived growth factor receptors. (1998) (2)
Deuterium isotope effect on the metabolism of the flame retardant tris(2,3-dibromopropyl) phosphate in the isolated perfused rat liver. (1995) (2)
MECHANISM OF SINUSOIDAL EFFLUX OF ORGANIC-ANIONS - ATP DEPENDENCY AND INFLUENCE OF EXTRACELLULAR PROTEIN-BINDING (1990) (2)
Liver slices as a tool to test anti-inflammatory agents in the liver. (1998) (2)
Hepatic transport of mono bisquaternary ammonium compounds. (1970) (2)
Drug Targeting with Glycoproteins and Other Peptide Carriers: An Overview (1994) (2)
MULTIPLE CARRIERS INVOLVED IN THE BILIARY-EXCRETION OF CATIONIC DRUGS (1995) (2)
[The excretory function of the liver; physiology of bile formation]. (1982) (1)
Succinylated alkaline phosphatase is a potent lipopolysaccharide (LPS) dephosphorylating enzyme and reduces intrahepatic inflammatory response in mice challenged with LPS. (1996) (1)
Lactoferrin against oral candidiasis. (2000) (1)
Effect of ethanol on hepatobiliary transport of cationic drugs. A study in the isolated perfused rat liver, rat hepatocytes and rat mitochondria. (1994) (1)
PERSPECTIVES IN DRUG AND GENE TARGETING WITH GLYCOPROTEINS AND OTHER MACROMOLECULAR CARRIERS (1994) (1)
Formation of a metabolite of dibromosulfophthalein (DBSP) in man (2004) (1)
Negatively charged albumins (1999) (1)
Choleresis and hepatic transport mechanisms (1977) (1)
Erratum to “Function and Regulation of ATP-binding cassette transport proteins involved in hepatobiliary transport”: [Eur. J. Pharm. Sci. 12 (2000) 13–29] (2001) (1)
MECHANISMS FOR UPTAKE OF CATIONIC DRUGS IN THE LIVER - A STUDY WITH TRIBUTYLMETHYLAMMONIUM CONCERNING SUBSTRATE-SPECIFICITY AND POTENTIAL DRIVING FORCES (1990) (1)
Oral Presentations—Abstracts (2003) (1)
The binding and uptake of hepatic stellate cell-selective drug carriers (1999) (1)
Endothelial and transendothelial delivery of pharmaceutically active agents; potential of liposomes (1998) (1)
STRUCTURE-PHARMACOKINETIC RELATIONSHIP OF ORGANIC CATIONS - THE INFLUENCE OF ION-PAIR FORMATION ON HEPATOBILIARY TRANSPORT (1984) (1)
Transport mechanisms for cationic drugs in liver, kidneys and intestine studied at the molecular level (1998) (1)
Mechanisms for uptake off the organic cation tri-butyl methyl ammonium in the hepatocyte (1990) (1)
Cellular distribution and handling of liver-targeting preparations in human livers studied by a liver lobe perfusion. (2001) (1)
HEPATIC DISPOSITION OF DIBROMOSULFTHALEIN IN ISOLATED PERFUSED RAT-LIVER - ALBUMIN DEPENDENCE AND INFLUENCE OF PHENOBARBITAL AND NAFENOPIN PRETREATMENT (1976) (1)
Transport of the liver specific MRI-contrast agent Gd-EOB-DTPA by the rat organic anion transporting polypeptide OATP1. (1998) (1)
PROTEIN STIMULATION OF ORGANIC ANION SECRETION FROM THE LIVER AT THE SINUSOIDAL LEVEL (1990) (1)
ZONAL AND INTRACELLULAR-DISTRIBUTION OF THE ORGANIC CATION LUCIGENIN - INFLUENCE OF TAUROCHOLATE (1988) (1)
Transfection of polarized kidney epithelial cells with the mdr1a, mdr1b or mdr1 gene induces vectorial transmembrane transport of type1 and type2 organic cations. (1997) (1)
NAPROXEN TARGETED TO HEPATIC NONPARENCHYMAL CELLS (NPC) PROTECTS AGAINST LIVER-DAMAGE INDUCED BY CORYNEBACTERIUM-PARVUM ENDOTOXIN (1994) (1)
A new human in vitro model to study early fibrogenesis. (2004) (1)
ALBUMIN SPECIFICALLY STIMULATES ORGANIC ANION SECRETION FROM THE LIVER AT THE SINUSOIDAL LEVEL (1989) (1)
Strong induction of MDR2 P-glycoprotein expression in livers of simvastatin-treated rats. (1997) (1)
On the hepatic uptake and biliary excretion of quaternary ammonium compounds (1972) (1)
TRANSPORT MECHANISMS FOR STEROIDAL CATIONIC DRUGS - RELATION BETWEEN HEPATOBILIARY TRANSPORT RATE AND SUBCELLULAR-DISTRIBUTION IN LIVER (1988) (1)
Renal handling of neutral and cationic low-molecular weight proteins during proteinuria (1997) (1)
Cell cycle-dependent regulation of hepatic ABC-transporters (1998) (1)
HETEROGENEOUS ACINAR LOCALIZATION OF ASIALOGLYCOPROTEIN TRANSPORT IN RAT-LIVER (1987) (1)
MODULATORS OF PROTEIN-KINASE-C AS WELL AS SUBSTRATES FOR THE P-GLYCOPROTEIN (MDR) SYSTEM HAVE A MAJOR INFLUENCE ON THE BILIARY-EXCRETION OF THE CATIONIC DRUG TRI-NORMAL-BUTYLMETHYLAMMONIUM (TBUMA) (1992) (1)
Further studies into the mechanism of interaction of negatively charged human serum albumins with the V3 loop of the HIV-1 envelope protein Gp120 (1995) (1)
Proceedings 23rd International Symposium on Controlled Release of Bioactive Materials (1996) (1)
A pharmacokinetic/pharmacodynamic model explaining the altered potency and time course of action of neuromuscular blocking agents in myasthenic patients (1997) (1)
EFFECTS OF HYPOLIPIDEMIC AGENTS NAFENOPIN AND CLOFIBRATE ON HEPATIC DISPOSITION OF ORGANIC COMPOUNDS IN RAT (1975) (0)
In vivo targeting to hepatic endothelial cells for the delivery of plasmid DNA using lipid based carriers (2003) (0)
Negatively charged human serum albumins as inhibitors of HIV-1 replication: mechanism of action, in vitro activity against distinct HIV-1 isolates and in vivo efficacy in mice (1997) (0)
Plasma proteins as drug carriers for hepatic and renal targeting (1996) (0)
COLLOIDAL GOLD AS AN ALTERNATIVE TO ENZYMES FOR CHARACTERIZATION OF PERIPORTAL AND PERIVENOUS RAT HEPATOCYTES (1988) (0)
Abstracts of papers Rational use of drugs (1989) (0)
STUDIES ON THE MECHANISM OF IMMUNE-COMPLEX BINDING TO LIVER-CELLS (1984) (0)
Chiral Differences in the Disposition of the Quaternary Anticholinergic Drug Oxyphenonium Bromide (1988) (0)
1567 – THE INFLUENCE OF PHENOBAEBITAL AND NAFENOPIN PRETREATMENT ON THE HEPATIC DISPOSITION OF DIBROMOSULPHTALEIN. THE ROLE OF Y AND Z PROTEINS (1977) (0)
TRANSCRIPTIONAL REGULATION OF THE RAT PHOSPHOLIPID TRANSLOCASE MDR 2 GENE EXPRESSION BY CHOLESTEROL SYNTHESIS INHIBITORS AND STEROL REGULATORY ELEMENT-BINDING PROTEINS (2000) (0)
INTRAHEPATIC ACINAR REDISTRIBUTION OF A CATIONIC DRUG DUE TO BOTH SINUSOIDAL SECRETION AND ACINAR HETEROGENEITY IN TRANSPORT AND BINDING (1987) (0)
HEPATOCYTE HETEROGENEITY IN TRANSPORT OF BILE-SALTS AND BROMSULFOPHTHALEIN, A KINETIC AND AUTORADIOGRAPHIC STUDY (1982) (0)
Drug-targeting to the kidney (1997) (0)
Hepatic distribution and biological effects of rocuronium (1996) (0)
Concentrations Do Not to Preterm Neonates , but Lactoferrin Transmission of Human Cytomegalovirus Viral Load in Breast Milk Correlates with (2001) (0)
HETEROGENEITY OF RAT HEPATOCYTES IN METABOLISM AND BILIARY TRANSPORT OF CHOLIC-ACID AND GLYCOCHOLIC ACID (1988) (0)
Natural and charge-modified proteins for viral infection therapy (2002) (0)
Human liver lobe perfusion (HLLP) as a tool for studying cellular distribution and handling of liver targeting preparations. (1998) (0)
CLONING OF THE CDNA ENCODING THE RAT MULTIDRUG RESISTANCE ( MDR ) 1 A P-GLYCOPROTEIN (2000) (0)
Reduction of advanced liver fi brosis by targeted delivery of the angiotensin II receptor antagonist losartan to hepatic stellate cells (2006) (0)
INTERFACIAL PHENOMENA AND KINETICS OF CYCLODEXTRIN-DRUG COMPLEXES (1987) (0)
ACINAR DIFFERENTIATION IN HEPATIC DISPOSITION OF THE ASIALOGLYCOPROTEIN ALKALINE-PHOSPHATASE, DIBROMOSULFTHALEIN AND BILE-SALTS (1980) (0)
322 A novel lipid-based drug carrier targeted to the non-parenchymal cells, including hepatic stellate cells, in the fibrotic livers of bile duct ligated rats (2006) (0)
Anti-HIV-1 activity of combinations and covalent conjugates of negatively charged albumins and AZT (1998) (0)
THE INFLUENCE OF TAUROCHOLATE ON THE HEPATIC TRANSPORT OF ASIALO-INTESTINAL ALKALINE-PHOSPHATASE (1982) (0)
DRUG TARGETING - FACT OR FICTION - RECEPTOR MEDIATED ENDOCYTOSIS AS A POTENTIAL MECHANISM FOR TISSUE-SPECIFIC DRUG DELIVERY (1985) (0)
Effects of bioactive liposomes on cultured hepatic stellate cells and liver fibrosis in bile duct ligated rats chapter 4 (2006) (0)
Targeting naproxen to endothelial (EC) and Kupffer cells (KC) protects against endotoxin in biliary cirrhosis (BC) in vivo (1996) (0)
LACTOSYLATED ALBUMIN - A POTENTIAL CARRIER FOR DRUG DELIVERY TO HEPATOCYTES (1985) (0)
Abstracts of papers (2005) (0)
Function and regulation of ATP-binding cassette transport proteins involved in hepatobiliary transport. (2001) (0)
1568 – HEPATIC TRANSPORT MECHANISMS: INTERACTION OF ANIONS AND BILIARY MICELLES (1977) (0)
The action of flecainide acetate and its enantiomers on mammalian non-myelinated nerve fibres (2005) (0)
University of Groningen Liver fibrosis in vitro (2017) (0)
MDR2 GENE EXPRESSION BY CHOLESTEROL SYNTHESIS INHIBITORS AND STEROL REGULATORY ELEMENT-BINDING PROTEINS (2000) (0)
DOSE-DEPENDANT DISPOSITION OF CARDIAC-GLYCOSIDES OUBAIN AND K-STROPHANTHOSIDE IN RAT-LIVER - CONSEQUENCES FOR (NA+,K+)-ATPASE INHIBITION AT SINUSOIDAL AND CANALICULAR SITES (1976) (0)
Abstracts of papers Biopharmaceutical meeting (2005) (0)
INFLUENCE OF BILE-SALTS ON HEPATOCELLULAR TRANSPORT OF DRUGS (1978) (0)
Exploring the regulation of endogenous alkaline phosphatase levels (2007) (0)
Dutch Pharmacological Meeting 1984 (1984) (0)
HEPATOCYTE HETEROGENEITY IN DBSP TRANSPORT IN NORMAL AND CCL4-DAMAGED LIVERS (1988) (0)
Modified plasma and milk proteins (1999) (0)
HETEROGENEITY OF HEPATOCYTES IN TRANSPORT OF DRUGS (1982) (0)
Mannose 6-phosphate modified albumin accumulates in hepatic stellate cells (1998) (0)
23RD INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1996 PROCEEDINGS (1997) (0)
Negatively charged human serum albumins: Inhibition of replication of primary HIV-1 isolates and biomolecular interaction with gp120 (1994) (0)
Proceedings of the Falk Symposium 102 (1998) (0)
Negatively charged human serum albumins: A novel class of polyanionic proteins with a potent anti-HIV-I activity (1995) (0)
Intestinal alkaline phosphatase is rapidly taken up by hepatocytes and protects these cells from lipopolysaccharide(LPS)-induced damage (2004) (0)
Hepatocellular uptake of organic cations by the organic anion transporting polypeptides (Oatp1, Oatp2 and OATP-A) and the organic cation transporters (rOCT1 and hOCT1) (2000) (0)
Drug targeting to hepatic stellate cells: a new strategy to treat liver fibrosis.: Chapter 25 (2006) (0)
3 2 DRUG UPTAKE SYSTEMS IN LIVER AND KIDNEY (2001) (0)
Abstracts of papers and posters Meeting on Pharmaceutical Sciences (1993) (0)
Drug delivery of captopril results in selective inhibition of the renal ACE (1999) (0)
Disposition kinetics and bioavailability of the glucosidase inhibitor N-benzyl-1-deoxynojirimycin after various routes of administration in mice (1997) (0)
TAGGING THE POTENTIAL-DRUG CARRIER ASIALO ALPHA-1-AGP WITH A FLUORESCENT-PROBE TO TRACK HEPATIC PROCESSING (1985) (0)
A single injection of alkaline phosphatase significantly attenuates the inflammatory response upon lipopolysaccharide (LPS) in serum and in livers of mice. (2001) (0)
Negatively charged albumins exhibit a potent invitro anti-HIV-1 activity and a unique inhibitory action on syncytium formation (1991) (0)
REDUCTASE INHIBITORS INDUCE HEPATIC EXPRESSION OF THE PHOSPHOLIPID TRANSLOCASE MDR2 P-GLYCOPROTEIN IN RATS (2000) (0)
ACUTELY ISOLATED HUMAN HEPATOCYTES - CHARACTERIZATION OF UPTAKE MECHANISMS FOR BILE-ACIDS AND DRUGS (1991) (0)
TARGETING OF ANTIVIRAL AGENTS TO LIVER AND CD4-POSITIVE CELLS BY NEOGLYCOPROTEINS (1990) (0)
Negatively charged human serum albumins as inhibitors of HIV-1 replication: Mechanism of action and in vivo efficacy in mice (1996) (0)
Effect of pentoxifylline on stellate cell activation in human liver slices (2018) (0)
and activated hepatic stellate cells IL-10 receptor and coreceptor expression in quiescent (2005) (0)
Membrane Transporters as Drug Targets (1999) (0)
Pharmacokinetics and drug delivery (2003) (0)
HEPATIC DISPOSITION OF CATIONIC DRUGS BOUND TO ASIALOOROSOMUCOID (ASOR) - LACK OF CO-ENDOCYTOSIS AND EVIDENCE FOR INTRAHEPATIC DISPOSITION (1987) (0)
Peptide-based carrier devices for stellate cells and other cell-types involved in chronic inflammatory and fibrotic disorders (2004) (0)
Alkaline phosphatase attenuates the response of macrophages upon lipopolysaccharide (LPS); A potential role for this enzyme during cholestasis. (2000) (0)
Relationship between Chemical Structure and Physicochemical Properties of Series of Bulky Organic Cations and Their Hepatic Uptake and Biliary Excretion Rates 1 (1997) (0)
Enhanced transgene delivery to activated vascular endothelial cells in vitro and in vivo using a novel strategy to modify adenovirus tropism (2004) (0)
Drug Targeting Strategy: Scrutinize the Concepts Before Screening the Constructs (2001) (0)
The monitoring of inflammatory responses in the human liver in vitro (1998) (0)
PHARMACOLOGICAL EFFECTS OF VALERIAN COMPOUNDS, WITH SPECIAL REFERENCE TO VALEPOTRIATES - CENTRAL DEPRESSANT OR SMOOTH-MUSCLE RELAXANT ACTION (1985) (0)
Immunoconjugate Cells Using an E-Selectin-Directed Dexamethasone into Activated Endothelial Selective Intracellular Delivery of Molema (2001) (0)
A novel lipid-based drug carrier targeted to the crucial cells in the development of liver fibrosis. (2004) (0)
Exacerbation of liver fibrosis after selective inhibition of cyclooxygenase-2 in Hepatic Stellate Cells (0)
Targeting of Cu,Zn superoxide dismutase to the liver attenuates ROS production in rats with fibrotic livers (1998) (0)
Preparation and characterization of conjugates of (modified) human serum albumin liposomes: Drug carriers with an intrinsic anti-HIV activity (1995) (0)
Anti-fibrotic effects of 15 d-Prostaglandin J 2 targeted to Hepatic Stellate Cells (0)
952 – THE CHOLERETIC EFFECT OF NAFENOPIN (1977) (0)
INFLUENCE OF BILE-SALT ADMINISTRATION AND BILIARY MICELLE FORMATION ON BILIARY ELIMINATION OF ORGANIC ANIONS (1975) (0)
Proceedings 12th World AIDS Conference (1998) (0)

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What Schools Are Affiliated With Dick K. F. Meijer?

Dick K. F. Meijer is affiliated with the following schools:

University of Groningen