David L. Brautigan
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Biology
David L. Brautigan's Degrees
- PhD Biochemistry University of California, Berkeley
- Bachelors Chemistry Stanford University
Why Is David L. Brautigan Influential?
(Suggest an Edit or Addition)David L. Brautigan's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Raf-1 activates MAP kinase-kinase (1992) (1210)
- Calyculin A and okadaic acid: inhibitors of protein phosphatase activity. (1989) (976)
- Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation. (1992) (615)
- Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A (1990) (558)
- Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient (2008) (375)
- Correlation of the kinetics of electron transfer activity of various eukaryotic cytochromes c with binding to mitochondrial cytochrome c oxidase. (1976) (353)
- Definition of cytochrome c binding domains by chemical modification. III. Kinetics of reaction of carboxydinitrophenyl cytochromes c with cytochrome c oxidase. (1978) (335)
- Agonists Trigger G Protein-mediated Activation of the CPI-17 Inhibitor Phosphoprotein of Myosin Light Chain Phosphatase to Enhance Vascular Smooth Muscle Contractility* (2000) (333)
- Mitochondrial cytochrome c: preparation and activity of native and chemically modified cytochromes c. (1978) (279)
- Expression of CPI‐17 and myosin phosphatase correlates with Ca2+ sensitivity of protein kinase C‐induced contraction in rabbit smooth muscle (2001) (248)
- Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts. (1994) (245)
- Regulation of NMDA receptors in cultured hippocampal neurons by protein phosphatases 1 and 2A (1994) (217)
- Phosphotyrosyl-protein phosphatase. Specific inhibition by Zn. (1981) (216)
- The Specificity of Extracellular Signal-regulated Kinase 2 Dephosphorylation by Protein Phosphatases* (2002) (210)
- B cell receptor-associated protein α4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A (1997) (207)
- Severe recurrent bacterial infections associated with defective adherence and chemotaxis in two patients with neutrophils deficient in a cell-associated glycoprotein. (1982) (196)
- Histamine-induced Vasoconstriction Involves Phosphorylation of a Specific Inhibitor Protein for Myosin Phosphatase by Protein Kinase C α and δ Isoforms* (2001) (191)
- Protein Ser/ Thr phosphatases – the ugly ducklings of cell signalling (2013) (190)
- Protein phosphatase type 1 in mammalian cell mitosis: chromosomal localization and involvement in mitotic exit (1992) (187)
- Cytoskeletal integrity in interphase cells requires protein phosphatase activity. (1992) (176)
- Protein phosphatases modulate the apparent agonist affinity of the light-regulated ion channel in retinal rods (1992) (175)
- Protein kinase activity closely associated with a reconstituted calcium-activated potassium channel. (1991) (175)
- Multiple low spin forms of the cytochrome c ferrihemochrome. EPR spectra of various eukaryotic and prokaryotic cytochromes c. (1977) (165)
- Differential signalling by muscarinic receptors in smooth muscle: m2-mediated inactivation of myosin light chain kinase via Gi3, Cdc42/Rac1 and p21-activated kinase 1 pathway, and m3-mediated MLC20 (20 kDa regulatory light chain of myosin II) phosphorylation via Rho-associated kinase/myosin phosphat (2003) (155)
- Protein Phosphatase 1 Is Targeted to Microtubules by the Microtubule-associated Protein Tau* (1998) (154)
- Phosphorylation of the myosin phosphatase inhibitors, CPI-17 and PHI-1, by integrin-linked kinase. (2002) (150)
- Protein phosphatase types 1 and/or 2A regulate nucleocytoplasmic shuttling of glucocorticoid receptors. (1991) (149)
- D-Chiro-Inositol Glycans in Insulin Signaling and Insulin Resistance (2010) (138)
- Activation of Myosin Light Chain Phosphatase in Intact Arterial Smooth Muscle During Nitric Oxide-induced Relaxation* (2001) (137)
- Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth (2017) (131)
- Ca(2+)-calmodulin-dependent protein kinases Ia and Ib from rat brain. II. Enzymatic characteristics and regulation of activities by phosphorylation and dephosphorylation. (1992) (130)
- Involvement of protein phosphatases 1 and 2A in the control of M phase- promoting factor activity in starfish (1989) (126)
- Targeting Protein Phosphatase 1 (PP1) to the Actin Cytoskeleton: the Neurabin I/PP1 Complex Regulates Cell Morphology (2002) (121)
- Discovery and characterization of small molecules that target the GTPase Ral (2014) (120)
- Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes. (1988) (119)
- Protein Phosphatase 6 Down-regulates TAK1 Kinase Activation in the IL-1 Signaling Pathway* (2006) (119)
- Protein phosphatase type-1, not type-2A, modulates actin microfilament integrity and myosin light chain phosphorylation in living nonmuscle cells (1990) (118)
- Dual Ser and Thr phosphorylation of CPI‐17, an inhibitor of myosin phosphatase, by MYPT‐associated kinase (2001) (118)
- Insulin activates the kinase activity of the Raf-1 proto-oncogene by increasing its serine phosphorylation. (1990) (117)
- Activation of Aurora-A kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein. (2004) (116)
- pp54 microtubule-associated protein-2 kinase requires both tyrosine and serine/threonine phosphorylation for activity. (1991) (114)
- Cellular chromium enhances activation of insulin receptor kinase. (2005) (112)
- Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains. (2008) (109)
- Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit α4 (2001) (109)
- Synergistic inhibition of human melanoma proliferation by combination treatment with B-Raf inhibitor BAY43-9006 and mTOR inhibitor Rapamycin (2005) (107)
- Cell cycle oscillation of phosphatase inhibitor-2 in rat fibroblasts coincident with p34 cdc2 restriction (1990) (106)
- Definition of cytochrome c binding domains by chemical modification. I. Reaction with 4-chloro-3,5-dinitrobenzoate and chromatographic separation of singly substituted derivatives. (1978) (104)
- A novel phosphoprotein inhibitor of protein type-1 phosphatase holoenzymes. (1999) (103)
- Inhibitor-2 Regulates Protein Phosphatase-1 Complexed with NimA-related Kinase to Induce Centrosome Separation* (2002) (101)
- The α4 Regulatory Subunit Exerts Opposing Allosteric Effects on Protein Phosphatases PP6 and PP2A* (2006) (100)
- Phosphoprotein inhibitor CPI-17 specificity depends on allosteric regulation of protein phosphatase-1 by regulatory subunits (2004) (99)
- Definitaion of cytochrome c binding domains by chemical modification. Reaction of carboxydinitrophenyl- and trinitrophenyl-cytochromes c with baker's yeast cytochrome c peroxidase. (1978) (95)
- Structurally different members of the okadaic acid class selectively inhibit protein serine/threonine but not tyrosine phosphatase activity. (1992) (95)
- Protein Serine/Threonine Phosphatases: Keys to Unlocking Regulators and Substrates. (2018) (94)
- Subunit structure and activation of inactive phosphorylase phosphatase. (1983) (93)
- Activation of DNA-PK by Ionizing Radiation Is Mediated by Protein Phosphatase 6 (2009) (92)
- Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2. (1999) (92)
- Cerebellar Long-Term Synaptic Depression Requires PKC-Mediated Activation of CPI-17, a Myosin/Moesin Phosphatase Inhibitor (2002) (90)
- Identification of protein phosphatase 2A as the primary target for microcystin‐LR in rat liver homogenates (1994) (88)
- A Novel Transmembrane Ser/Thr Kinase Complexes with Protein Phosphatase-1 and Inhibitor-2* (2002) (87)
- Protein Phosphatase 6 Subunit with Conserved Sit4-associated Protein Domain Targets IκBϵ* (2006) (86)
- Histamine-induced vasoconstriction involves phosphorylation of a specific inhibitor protein for myosin phosphatase by protein kinase C alpha and delta isoforms. (2001) (86)
- Methods to distinguish various types of protein phosphatase activity. (1988) (85)
- Preparation of cytochrome c2 from Rhodospirillum rubrum. (1976) (85)
- Androgen receptor degradation by the E3 ligase CHIP modulates mitotic arrest in prostate cancer cells (2014) (84)
- B cell receptor-associated protein alpha4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A. (1997) (78)
- Neurabins Recruit Protein Phosphatase-1 and Inhibitor-2 to the Actin Cytoskeleton* (2002) (77)
- Protein Phosphatase-1α Regulates Centrosome Splitting through Nek2 (2007) (77)
- Expression of Ral GTPases, Their Effectors, and Activators in Human Bladder Cancer (2007) (76)
- Inhibition of T-type calcium channels disrupts Akt signaling and promotes apoptosis in glioblastoma cells. (2013) (76)
- Uterine estrogen receptor in vivo: phosphorylation of nuclear specific forms on serine residues. (1991) (74)
- Activation of membrane protein-tyrosine phosphatase involving cAMP- and Ca2+/phospholipid-dependent protein kinases. (1991) (73)
- Simian Virus 40 Small t Antigen Mediates Conformation-Dependent Transfer of Protein Phosphatase 2A onto the Androgen Receptor (2005) (71)
- Selective PP2A Enhancement through Biased Heterotrimer Stabilization (2020) (71)
- Growth arrest induced by transforming growth factor beta 1 is accompanied by protein phosphatase activation in human keratinocytes. (1991) (71)
- Flicking the switches: phosphorylation of serine/threonine protein phosphatases. (1995) (69)
- Great expectations: protein tyrosine phosphatases in cell regulation. (1992) (68)
- Definition of cytochrome c binding domains by chemical modification. II. Identification and properties of singly substituted carboxydinitrophenyl cytochromes c at lysines 8, 13, 22, 27, 39, 60, 72, 87, and 99. (1978) (67)
- Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon. (2006) (66)
- Cytosolic protein phosphotyrosine phosphatases from rabbit kidney. Purification of two distinct enzymes that bind to Zn2+-iminodiacetate agarose. (1984) (66)
- Ionizing Radiation Activates Nuclear Protein Phosphatase-1 by ATM-dependent Dephosphorylation* (2002) (64)
- Phosphatase inhibitor-2 balances protein phosphatase 1 and aurora B kinase for chromosome segregation and cytokinesis in human retinal epithelial cells. (2008) (63)
- Transforming Growth Factor β-activated Kinase 1 (TAK1) Kinase Adaptor, TAK1-binding Protein 2, Plays Dual Roles in TAK1 Signaling by Recruiting Both an Activator and an Inhibitor of TAK1 Kinase in Tumor Necrosis Factor Signaling Pathway* (2009) (63)
- Cytokine Activation of p38 Mitogen-Activated Protein Kinase and Apoptosis Is Opposed by alpha-4 Targeting of Protein Phosphatase 2A for Site-Specific Dephosphorylation of MEK3 (2007) (63)
- Definition of enzymic interaction domains on cytochrome c. Purification and activity of singly substituted carboxydinitrophenyl-lysine 7, 25, 73, 86, and 99 cytochromes c. (1980) (63)
- Differential localization of myosin and myosin phosphatase subunits in smooth muscle cells and migrating fibroblasts. (1997) (60)
- Defining the Structural Determinants and a Potential Mechanism for Inhibition of Myosin Phosphatase by the Protein Kinase C-potentiated Inhibitor Protein of 17 kDa* (2001) (59)
- Phosphorylation of the Myosin-binding Subunit of Myosin Phosphatase by Raf-1 and Inhibition of Phosphatase Activity* (2002) (58)
- Ligand Binding to the Androgen Receptor Induces Conformational Changes That Regulate Phosphatase Interactions (2007) (57)
- Protein phosphatase-1alpha regulates centrosome splitting through Nek2. (2007) (55)
- Activation of a protein tyrosine phosphatase and inactivation of Raf-1 by somatostatin. (1996) (54)
- Phosphorylation of RalB is important for bladder cancer cell growth and metastasis. (2010) (54)
- Protein phosphatase 2A suppresses MAP kinase signalling and ectopic protein expression. (1999) (53)
- Phosphorylation and functions of inhibitor-2 family of proteins. (2007) (52)
- Glycogen Synthase Association with the Striated Muscle Glycogen-targeting Subunit of Protein Phosphatase-1 (2000) (50)
- Protection against the synaptic targeting and toxicity of Alzheimer's‐associated Aβ oligomers by insulin mimetic chiro‐inositols (2013) (50)
- Separate intramolecular pathways for reduction and oxidation of cytochrome c in electron transport chain reactions. (1973) (49)
- Molecular basis for substrate specificity of protein kinases and phosphatases. (1986) (49)
- TAB4 Stimulates TAK1-TAB1 Phosphorylation and Binds Polyubiquitin to Direct Signaling to NF-κB* (2008) (49)
- Phosphorylase phosphatase catalytic subunit. Evidence that the Mr = 33,000 enzyme fragment is derived from a native protein of Mr = 70,000. (1985) (49)
- Inhibition of myosin/moesin phosphatase by expression of the phosphoinhibitor protein CPI-17 alters microfilament organization and retards cell spreading. (2000) (49)
- 4 – The Electron Transfer Function of Cytochrome c * (1979) (49)
- Phosphorylation of Phosphatase Inhibitor-2 at Centrosomes during Mitosis* (2003) (49)
- Phosphorylation of protein phosphatase type-1 inhibitory proteins by integrin-linked kinase and cyclic nucleotide-dependent protein kinases. (2003) (48)
- Proper Chromatin Condensation and Maintenance of Histone H3 Phosphorylation During Mouse Oocyte Meiosis Requires Protein Phosphatase Activity1 (2007) (48)
- Tensin1 Requires Protein Phosphatase-1α in Addition to RhoGAP DLC-1 to Control Cell Polarization, Migration, and Invasion* (2009) (48)
- Protein Phosphatase PP6 N Terminal Domain Restricts G1 to S Phase Progression in Human Cancer Cells (2007) (48)
- Mapping of anion binding sites on cytochrome c by differential chemical modification of lysine residues. (1980) (48)
- Angiotensin II regulates phosphorylation of translation elongation factor-2 in cardiac myocytes. (2001) (47)
- A conserved domain for glycogen binding in protein phosphatase‐1 targeting subunits (1998) (47)
- Allosteric activation of protein phosphatase 2C by D-chiro-inositol-galactosamine, a putative mediator mimetic of insulin action. (2005) (46)
- Phosphorylation-induced conformational switching of CPI-17 produces a potent myosin phosphatase inhibitor. (2007) (46)
- Role of Adenosine in the Maintenance of Coronary Vasodilation Distal to a Severe Coronary Artery Stenosis (1983) (46)
- Partial purification and characterization of phosphotyrosyl-protein phosphatase from Ehrlich ascites tumor cells. (1982) (46)
- T-Type Ca2+ Channel Inhibition Induces p53-Dependent Cell Growth Arrest and Apoptosis through Activation of p38-MAPK in Colon Cancer Cells (2013) (46)
- PP2A regulates ionizing radiation–induced apoptosis through Ser46 phosphorylation of p53 (2009) (45)
- Specificity of protein phosphotyrosine phosphatases. Comparison with mammalian alkaline phosphatase using polypeptide substrates. (1985) (44)
- Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer. (2018) (44)
- The Phosphatase Ptc7 Induces Coenzyme Q Biosynthesis by Activating the Hydroxylase Coq7 in Yeast* (2013) (43)
- Overlapping Binding Sites in Protein Phosphatase 2A for Association with Regulatory A and α-4 (mTap42) Subunits* (2004) (41)
- Differential regulation of multiple hepatic protein tyrosine phosphatases in alloxan diabetic rats. (1992) (41)
- Respiratory-induced coenzyme Q biosynthesis is regulated by a phosphorylation cycle of Cat5p/Coq7p. (2011) (41)
- Solution NMR structure of the myosin phosphatase inhibitor protein CPI-17 shows phosphorylation-induced conformational changes responsible for activation. (2001) (40)
- Peptide Microarray Analysis of Substrate Specificity of the Transmembrane Ser/Thr Kinase KPI-2 Reveals Reactivity with Cystic Fibrosis Transmembrane Conductance Regulator and Phosphorylase*S (2006) (40)
- Lysolecithin as feed additive enhances collagen expression and villus length in the jejunum of broiler chickens (2017) (39)
- Protein phosphatase type-1 and type-2 catalytic subunits both bind inhibitor-2 and monoclonal immunoglobulins. (1986) (39)
- Assembly of MYPT1 with protein phosphatase-1 in fibroblasts redirects localization and reorganizes the actin cytoskeleton. (2005) (39)
- The structure of Tap42/alpha4 reveals a tetratricopeptide repeat-like fold and provides insights into PP2A regulation. (2007) (39)
- Hepatic protein phosphotyrosine phosphatase. Dephosphorylation of insulin and epidermal growth factor receptors in normal and alloxan diabetic rats. (1990) (39)
- Phosphorylation of the Pro-X-Thr-Pro site in phosphatase inhibitor-2 by cyclin-dependent protein kinase during M-phase of the cell cycle. (2006) (39)
- Aurora-A Kinase and Inhibitor-2 Regulate the Cyclin Threshold for Mitotic Entry in Xenopus Early Embryonic Cell Cycles (2006) (39)
- Comprehensive analysis of receptor tyrosine kinase activation in human melanomas reveals autocrine signaling through IGF-1R (2011) (38)
- Endotoxin Conditioning Induces VCP/p97-mediated and Inducible Nitric-oxide Synthase-dependent Tyr284 Nitration in Protein Phosphatase 2A* (2010) (38)
- Multisite Phosphorylation and the Nuclear Localization of Phosphatase Inhibitor 2-Green Fluorescent Protein Fusion Protein during S Phase of the Cell Growth Cycle* (1997) (37)
- Human melanoma cytolysis by combined inhibition of mammalian target of rapamycin and vascular endothelial growth factor/vascular endothelial growth factor receptor-2. (2008) (36)
- Regulatory Crosstalk by Protein Kinases on CFTR Trafficking and Activity (2016) (36)
- Histone H1 Dephosphorylation Is Mediated through a Radiation-induced Signal Transduction Pathway Dependent on ATM* (1999) (36)
- Protein phosphotyrosine phosphatase purified from the particulate fraction of human placenta dephosphorylates insulin and growth-factor receptors. (1988) (35)
- LMTK2-mediated Phosphorylation Regulates CFTR Endocytosis in Human Airway Epithelial Cells* (2014) (35)
- PP6 Regulatory Subunit R1 Is Bidentate Anchor for Targeting Protein Phosphatase-6 to DNA-dependent Protein Kinase* (2012) (35)
- Activation of skeletal muscle phosphorylase phosphatase. Effects of proteolysis and divalent cations. (1982) (35)
- Inactivation of Raf-1 by a Protein-tyrosine Phosphatase Stimulated by GTP and Reconstituted by G Subunits (*) (1996) (34)
- Systems analyses characterize integrated functions of biochemical networks. (2006) (34)
- Insulin-stimulated Phosphorylation of the Protein Phosphatase-1 Striated Muscle Glycogen-targeting Subunit and Activation of Glycogen Synthase* (2000) (32)
- Comprehensive Analysis of Phosphorylation Sites in Tensin1 Reveals Regulation by p38MAPK* (2010) (32)
- Endogenous inhibitor proteins that connect Ser/Thr kinases and phosphatases in cell signaling (2012) (32)
- Association of the Tensin N-terminal Protein-tyrosine Phosphatase Domain with the α Isoform of Protein Phosphatase-1 in Focal Adhesions* (2007) (32)
- α–SNAP inhibits AMPK signaling to reduce mitochondrial biogenesis and dephosphorylates Thr172 in AMPKα in vitro (2013) (32)
- Protein phosphatase type-1 and glycogen bind to a domain in the skeletal muscle regulatory subunit containing conserved hydrophobic sequence motif. (1996) (31)
- ATM regulates ionizing radiation-induced disruption of HDAC1:PP1:Rb complexes. (2007) (31)
- Phosphorylase phosphatase complex from skeletal muscle. Activation of one of two catalytic subunits by manganese ions. (1980) (30)
- ATM-dependent dissociation of B55 regulatory subunit from nuclear PP2A in response to ionizing radiation. (2001) (29)
- Apoptosis of CD4+CD25high T cells in response to Sirolimus requires activation of T cell receptor and is modulated by IL-2 (2009) (29)
- Tyrosylprotein kinase and phosphatase activities in membrane vesicles from normal and Rous sarcoma virus-transformed rat cells. (1981) (29)
- The E3 Ligase CHIP Mediates p21 Degradation to Maintain Radioresistance (2017) (29)
- Induction of hepatic glycogenesis in the fetal rat. (1989) (28)
- Clinical Activity and Safety of Combination Therapy with Temsirolimus and Bevacizumab for Advanced Melanoma: A Phase II Trial (CTEP 7190/Mel47) (2013) (28)
- Sphingosine-1-phosphate enhances IL-1{beta}-induced COX-2 expression in mouse intestinal subepithelial myofibroblasts. (2008) (28)
- Fluorescence lifetime imaging (FLIM) of green fluorescent fusion proteins in living cells. (2002) (27)
- Phosphorylase phosphatase regulatory subunit. "Western" blotting with immunoglobulins against inhibitor-2 reveals a protein of Mr = 60,000. (1985) (26)
- Membrane protein phosphotyrosine phosphatase in rabbit kidney. Proteolysis activates the enzyme and generates soluble catalytic fragments. (1987) (25)
- Human Protein Phosphatase PP6 Regulatory Subunits Provide Sit4-Dependent and Rapamycin–Sensitive Sap Function in Saccharomyces cerevisiae (2009) (25)
- Phosphatases as partners in signaling networks. (1997) (24)
- Cinnamic Acid Derivatives Enhance the Efficacy of Transarterial Embolization in a Rat Model of Hepatocellular Carcinoma (2017) (24)
- Aurora Kinase A Promotes AR Degradation via the E3 Ligase CHIP (2017) (24)
- Binding of phosphatase inhibitor-2 to prolyl isomerase Pin1 modifies specificity for mitotic phosphoproteins. (2008) (24)
- Chromium and vanadate combination increases insulin-induced glucose uptake by 3T3-L1 adipocytes. (2006) (24)
- Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa (2013) (23)
- Mutations of the serine phosphorylated in the protein phosphatase-1-binding motif in the skeletal muscle glycogen-targeting subunit. (2000) (23)
- Maternal Phosphatase Inhibitor-2 Is Required for Proper Chromosome Segregation and Mitotic Synchrony During Drosophila Embryogenesis (2008) (23)
- Adenosine's role in regulating basal coronary arteriolar tone. (1986) (23)
- Transgenic expression of protein phosphatase 2A regulatory subunit B56gamma disrupts distal lung differentiation. (2002) (23)
- Mapping of protein phosphatase-6 association with its SAPS domain regulatory subunit using a model of helical repeats (2009) (22)
- Phosphatase inhibitor 2 promotes acetylation of tubulin in the primary cilium of human retinal epithelial cells (2008) (22)
- Differentiation-induced changes in protein-tyrosine phosphatase activity and commensurate expression of CD45 in human leukemia cell lines. (1992) (22)
- Serine phosphorylation of protein tyrosine phosphatase (PTP1B) in HeLa cells in response to analogues of cAMP or diacylglycerol plus okadaic acid (1993) (21)
- VEGFR‐2 expression in human melanoma: Revised assessment (2011) (21)
- ATM-dependent Dissociation of B55 Regulatory Subunit from Nuclear PP2A in Response to Ionizing Radiation* (2002) (21)
- PKCα phosphorylation of RhoGDI2 at Ser 31 disrupts interactions with Rac1 and decreases GDI activity (2012) (20)
- Functions of protein phosphatase-6 in NF-κB signaling and in lymphocytes (2017) (20)
- Equivalent uptake of organic and inorganic zinc by monkey kidney fibroblasts, human intestinal epithelial cells, or perfused mouse intestine (2007) (20)
- Selective toxicity of caffeic acid in hepatocellular carcinoma cells. (2018) (20)
- Attenuation of ribosomal protein S6 phosphatase activity in chicken embryo fibroblasts transformed by Rous sarcoma virus (1994) (19)
- Distinctive solution conformation of phosphatase inhibitor CPI-17 substituted with aspartate at the phosphorylation-site threonine residue. (2003) (19)
- Insulin and glucose 6-phosphate stimulation of Ca2+ uptake by skinned muscle fibers. (1980) (19)
- Deficiency in phosphorylase phosphatase activity despite elevated protein phosphatase type-1 catalytic subunit in skeletal muscle from insulin-resistant subjects. (1991) (18)
- Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors (2019) (18)
- Interleukio 2 stimulates serine phosphorylation of CD45 in CTLL‐2.4 cells (1991) (18)
- Modulation of type‐1 protein phosphatase by synthetic peptides corresponding to the carboxyl terminus (1991) (17)
- Domains of type 1 protein phosphatase inhibitor-2 required for nuclear and cytoplasmic localization in response to cell-cell contact (2002) (17)
- Protein Ser/Thr phosphatase-6 is required for maintenance of E-cadherin at adherens junctions (2013) (16)
- Low-temperature studies of electron transfer between different cytochromes c and cytochrome c oxidase. (1978) (16)
- A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling (2021) (16)
- Wide-Field, Confocal, Two-Photon, and Lifetime Resonance Energy Transfer Imaging Microscopy (2001) (16)
- Ciliopathy-Associated Protein Kinase ICK Requires Its Non-Catalytic Carboxyl-Terminal Domain for Regulation of Ciliogenesis (2019) (16)
- RhoC Is an Unexpected Target of RhoGDI2 in Prevention of Lung Colonization of Bladder Cancer (2014) (16)
- Synthesis of C-glycoside analogues of beta-galactosamine-(1-->4)-3-O-methyl-D-chiro-inositol and assay as activator of protein phosphatases PDHP and PP2Calpha. (2010) (16)
- Hepatic protein tyrosine phosphatases in the rat. (1991) (15)
- Ciliogenesis associated kinase 1: targets and functions in various organ systems (2019) (15)
- The Use of the Woodchuck as an Animal Model for Evaluation of Transarterial Embolization. (2017) (15)
- Regulation of an epithelial chloride channel by direct phosphorylation and dephosphorylation. (1992) (15)
- Molecular basis for an ancient partnership between prolyl isomerase Pin1 and phosphatase inhibitor-2. (2011) (15)
- High-content phenotypic assay for proliferation of human iPSC-derived cardiomyocytes identifies L-type calcium channels as targets. (2019) (14)
- Modulation of NKG2D, NKp46, and Ly49C/I facilitates natural killer cell-mediated control of lung cancer (2018) (14)
- Subunit composition and developmental regulation of hepatic protein phosphatase 2A (PP2A). (2007) (14)
- A phosphatase by any other name: from prosthetic group removing enzyme to phosphorylase phosphatase (1982) (13)
- Focus on Women (1995) (13)
- Concurrent purification of type-1 and type-2A protein phosphatase catalytic subunits. (1994) (13)
- Profiling Subcellular Protein Phosphatase Responses to Coxsackievirus B3 Infection of Cardiomyocytes* (2017) (13)
- Migration and retraction of endothelial and epithelial cells require PHI-1, a specific protein-phosphatase-1 inhibitor protein (2004) (13)
- The α4‐containing form of protein phosphatase 2A in liver and hepatic cells (2008) (13)
- Protein phosphatase 1α interacts with a novel ciliary targeting sequence of polycystin‐1 and regulates polycystin‐1 trafficking (2019) (12)
- The Discodermia calyx Toxin Calyculin A Enhances Cyclin D1 Phosphorylation and Degradation, and Arrests Cell Cycle Progression in Human Breast Cancer Cells (2011) (12)
- Developmental expression of α4 protein phosphatase regulatory subunit in tissues affected by Opitz syndrome (2002) (12)
- Latent forms of type-1 protein phosphatase in rabbit skeletal muscle. (1987) (12)
- Do evolutionary changes in cytochrome c structure reflect functional adaptations? (1976) (11)
- Mitotic phosphorylation activates hepatoma-derived growth factor as a mitogen (2011) (11)
- Inhibition of Breast Cancer Metastasis Suppressor 1 Promotes a Mesenchymal Phenotype in Lung Epithelial Cells That Express Oncogenic K-RasV12 and Loss of p53 (2014) (11)
- Xanthophylls lutein and zeaxanthin modify gene expression and induce synthesis of hyaluronan in keratinocyte model of human skin (2015) (11)
- Activation of glycogen synthase in myocardium induced by intermittent hypoxia is much lower in fasted than in fed rats. (2007) (10)
- Phosphoprotein inhibitors of protein phosphatase-1. (2003) (10)
- Sequence homologies between type 1 and type 2A protein phosphatases. (1987) (10)
- Dephosphorylation of skeletal muscle phosphorylase, glycogen synthase, and phosphorylase kinase beta-subunit by a Mn2+-activated protein phosphatase. (1982) (10)
- Phosphosite T674A mutation in kinesin family member 3A fails to reproduce tissue and ciliary defects characteristic of CILK1 loss of function (2020) (10)
- Functional Alterations in Ciliogenesis-Associated Kinase 1 (CILK1) that Result from Mutations Linked to Juvenile Myoclonic Epilepsy (2020) (9)
- Protein phosphatases. (1994) (9)
- Juxtamembrane localization of the protein phosphatase-1 inhibitor protein PHI-1 in smooth muscle cells (2004) (9)
- Inhibition of human breast cancer Matrigel invasion by Streptolysin O activation of the EGF receptor ErbB1. (2011) (8)
- Calyculin A from Discodermia Calyx Is a Dual ActionToxin that Blocks Calcium Influx and Inhibits Protein Ser/Thr Phosphatases (2012) (8)
- Modulation of GSK3β autoinhibition by Thr‐7 and Thr‐8 (2018) (7)
- Molecular defects in ion channel regulation in cystic fibrosis predicted from analysis of protein phosphorylation/dephosphorylation. (1988) (7)
- Metal chelate affinity chromatography of Zn2+-inhibited protein Tyr(P) phosphatases. (1987) (6)
- Aurora B Kinase Promotes CHIP-Dependent Degradation of HIF1α in Prostate Cancer Cells (2019) (6)
- Targeting protein phosphatase PP2A for cancer therapy: development of allosteric pharmaceutical agents. (2021) (6)
- Protein phosphatase type 1 catalytic subunit forms nondissociable dimers. (1989) (6)
- Tyrosine phosphorylation of phosphatase inhibitor 2 (1995) (5)
- Renal AT2 Receptors Mediate Natriuresis via Protein Phosphatase PP2A (2021) (4)
- Deletion of the SAPS1 subunit of protein phosphatase 6 in mice increases radiosensitivity and impairs the cellular DNA damage response. (2019) (4)
- Transcriptome-wide association study and eQTL colocalization identify potentially causal genes responsible for human bone mineral density GWAS associations (2021) (4)
- Compartmentalized protein phosphorylation/dephosphorylation in glycogen particles from rabbit skeletal muscle. (1988) (4)
- Dephosphorylation of Insulin and Epidermal Growth Factor Receptors in Normal and Alloxan Diabetic Rats (1990) (3)
- Clinical activity and safety of combination therapy with temsirolimus and bevacizumab for advanced melanoma: Phase II trial with correlative studies. (2012) (3)
- Proposal for a pathway to mediate the metabolic effects of insulin. (1988) (3)
- Breakthroughs in Bioscience (2004) (3)
- Meeting Report: Targeting Protein Phosphatases-Medicines for the New Millenium (2000) (3)
- Fluorescence lifetime imaging of green fluorescent protein in a single living cell (1999) (2)
- Protein kinase CK2 phosphorylation of SAPS3 subunit increases PP6 phosphatase activity with Aurora A kinase. (2020) (2)
- PP 2 A regulates ionizing radiation – induced apoptosis through Ser 46 phosphorylation of p 53 (2008) (2)
- DEFINITION OF THE SURFACE OF CYTOCHROME c INTERACTING WITH CYTOCHROME OXIDASE 1 (1979) (1)
- Protein Ser/Thr phosphatase-6 is required for maintenance of E-cadherin at adherens junctions (2013) (1)
- Discovery and characterization of small molecules that target the Ral GTPase (2014) (1)
- Phosphorylation-induced conformational change responsible for the function of a myosin phosphatase inhibitor, CPI-17 (2004) (1)
- Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa (2013) (1)
- Regulatory Subunit R 1 Is Bidentate Anchor for Targeting Protein Phosphatase-6 to DNA-dependent Protein Kinase * (2012) (1)
- Phosphorylase phosphatase and flash activation of skeletal muscle glycogen phosphorylase—A tribute to Edmond H. Fischer (2022) (1)
- HDAC1 and Nek2 are targets of IR-activated PP1c (2003) (1)
- Assay for three-way interaction of protein phosphatase-1 (Glc7) with regulatory subunits plus phosphatase inhibitor-2. (2007) (1)
- Modulation of Primary Cilia by Alvocidib Inhibition of CILK1 (2022) (1)
- Passing or failing? Is biomedical science meeting national needs? (1993) (1)
- Erratum: Allosteric activation of protein phosphatase 2C by D-chiro-inositol-galactosamine, a putative mediator mimetic of insulin action (Biochemistry (August 23, 2005) 44, 33 (11067-11073)) (2005) (1)
- Phosphorylation of chloroform soluble compounds in plasma membranes of human epidermoid carcinoma A431 cells (1985) (1)
- Phosphorylation in the Regulation of Protein Phosphatases (1994) (0)
- IR-induced dephosphorylation of PP1 is controlled by ATM (2001) (0)
- Abstract A239: T-type calcium channels as a novel molecular target for tumor therapy. (2013) (0)
- Incorporating Minorities in Science (1994) (0)
- Chromatographic isolation of PP2A from Limulus lateral eyes. Conventional and small scale methods. (1998) (0)
- Abstract 311: Phosphorylation of RalB by PKC regulates its intracellular distribution and promotion of bladder tumor growth (2010) (0)
- Regulation of Skeletal Muscle Phosphatases by Mn 2 + and Sulfhydryl-Disulfide Interchange (1981) (0)
- Solution structure of CPI-17(22-120) (2003) (0)
- 04:03 PM Abstract No. 390 Pharmacokinetic verification of loco-regional delivery of caffeic acid using drug-eluting beads in a large animal model (2019) (0)
- Abstract B102: Zibotentan (ZD4054), a specific antagonist of the endothelin A receptor, suppresses the metastatic phenotype of bladder cancer cells in vivo (2009) (0)
- Selective Focused Projection of Molecular Structures and Other Three-Dimensional Arrays. (1974) (0)
- WS4.5 LMTK2 regulates CFTR endocytosis by phosphorylation at CFTR Ser-737 (2013) (0)
- Localization of bleomycin in a single living cell using three-photon excitation microscopy (2001) (0)
- Effect of OA Microinjection at Various Stages of Meiotic Maturation on H 1 Histone Kinase and MPF Activities of Starfish Oocytes (2002) (0)
- TGF-β SIGNALING IN CYSTIC FIBROSIS – A ROLE FOR LMTK2 AND PP1C (2015) (0)
- INTRINSIC REGULATION OF GLYCOGEN PARTICLES: LIVER v. SKELETAL MUSCLE (1987) (0)
- Animal Models of Hepatocellular Carcinoma for Local-Regional Intraarterial Therapies. (2022) (0)
- Abstract 2981: Biased activation of PP2A through selective heterotrimer binding and stabilization (2020) (0)
- Fluorescence lifetime imaging of green fluorescent protein in a single living cell : Functional Imaging and Optical Manipulation of Living Cells (1999) (0)
- Characterizing the interactions between prolyl isomerase pin1 and phosphatase inhibitor-2 in living cells with FRET and FCS (2012) (0)
- CoupledPhosphataseandKinaseSwitchesProducethe TristabilityRequiredforLong-TermPotentiationandLong- TermDepression (2008) (0)
- Backbone 1H, 13C, 15N and sidechain 1H Chemical shift of CPI-17 (2002) (0)
- Protein phosphatase inhibitor-2 (2006) (0)
- Abstract 18674: High-Content Phenotypic Screen for Compounds that Induce Proliferation of Human iPSC-Derived Cardiomyocytes (2016) (0)
- Solution structure of CPI-17(22-120) T38D (2003) (0)
- A Reply to 'Cellular Toxicity of iHAP1 and DT-061 Does Not Occur Through PP2A-B56 Targeting' (2021) (0)
- Cell Death and Survival T-Type Ca 2 þ Channel Inhibition Induces p 53-Dependent Cell Growth Arrest and Apoptosis through Activation of p 38-MAPK in Colon Cancer Cells (2014) (0)
- Abstract 4173: Drug target mutations as a mechanism of acquired resistance to small molecules activators of protein phosphatase 2a (2017) (0)
- Abstract B124: Drugging the undruggable: development of small molecule activators of protein phosphatase 2A for cancer treatment (2015) (0)
- Disulfide bonds in the catalytic subunit of skeletal muscle protein phosphatase (1986) (0)
- A High‐throughput Assay Platform for Quantifying Nucleo‐cytoplasmic Phosphatase Activity (2017) (0)
- Breakthroughs in Bioscience 1 GENETICS Genes Make the Headline News “ News Flash ! (2003) (0)
- Structural insight into regulation of myosin phosphatase by CPI‐17. (2007) (0)
- Dynamic Interconversion of Receptors Involving Dephosphorylation by Protein Tyr(P) and Ser(P)/Thr(P) Phosphatases (2018) (0)
- Abstract 3865: Therapeutic activation of protein phosphatase 2A for the treatment of lung cancer (2016) (0)
- CPI-17(35-120) deletion mutant (2002) (0)
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What Schools Are Affiliated With David L. Brautigan?
David L. Brautigan is affiliated with the following schools:
