David Mervyn Blow
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Biochemistry
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Chemistry Biology
Why Is David Mervyn Blow Influential?
(Suggest an Edit or Addition)David Mervyn Blow's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Hydrogen bonding and biological specificity analysed by protein engineering (1985) (880)
- The detection of sub‐units within the crystallographic asymmetric unit (1962) (860)
- Structure of crystalline -chymotrypsin. V. The atomic structure of tosyl- -chymotrypsin at 2 A resolution. (1972) (578)
- The treatment of errors in the isomorphous replacement method (1959) (451)
- Structure and mechanism of chymotrypsin (1976) (395)
- Crystal structure of the complex of porcine trypsin with soybean trypsin inhibitor (Kunitz) at 2.6-A resolution. (1974) (383)
- Structure of crystalline -chymotrypsin. II. A preliminary report including a hypothesis for the activation mechanism. (1968) (355)
- Structure of crystalline α-chymotrypsin: III. Crystallographic studies of substrates and inhibitors bound to the active site of α-chymotrypsin (1969) (315)
- Structure of tyrosyl-tRNA synthetase refined at 2.3 A resolution. Interaction of the enzyme with the tyrosyl adenylate intermediate. (1989) (308)
- A method of positioning a known molecule in an unknown crystal structure (1967) (263)
- Structure of alpha-chymotrypsin refined at 1.68 A resolution. (1985) (233)
- An Automated System for Micro-Batch Protein Crystallization and Screening (1990) (228)
- Site-directed mutagenesis as a probe of enzyme structure and catalysis: tyrosyl-tRNA synthetase cysteine-35 to glycine-35 mutation. (1983) (221)
- Microbatch crystallization under oil — a new technique allowing many small-volume crystallization trials (1992) (215)
- Crystal structure of cholesterol oxidase complexed with a steroid substrate: implications for flavin adenine dinucleotide dependent alcohol oxidases. (1993) (176)
- Crystal structure of carboxypeptidase G2, a bacterial enzyme with applications in cancer therapy. (1997) (167)
- X-ray diffraction studies of enzymes. (1970) (152)
- Mechanism for aldose-ketose interconversion by D-xylose isomerase involving ring opening followed by a 1,2-hydride shift. (1993) (147)
- Crystal structure of cholesterol oxidase from Brevibacterium sterolicum refined at 1.8 A resolution. (1991) (146)
- Outline of Crystallography for Biologists (2002) (140)
- A large increase in enzyme–substrate affinity by protein engineering (1984) (131)
- Crystal structure of a Kunitz-type trypsin inhibitor from Erythrina caffra seeds. (1991) (129)
- Tyrosyl-tRNA synthetase forms a mononucleotide-binding fold. (1982) (117)
- Crystal structure of a deletion mutant of a tyrosyl-tRNA synthetase complexed with tyrosine. (1987) (110)
- The single isomorphous replacement method (1961) (106)
- Leaving group specificity in the chymotrypsin-catalyzed hydrolysis of peptides. A stereochemical interpretation. (1973) (101)
- Formation of a Helical Steroid Complex (1958) (101)
- A model for the association of bovine pancreatic trypsin inhibitor with chymotrypsin and trypsin. (1972) (100)
- The crystal structure of tyrosyl-transfer RNA synthetase at 2-7 A resolution. (1976) (95)
- Studies on the Formation of Helical Deoxycholate Complexes1,2 (1960) (90)
- Structures of D-xylose isomerase from Arthrobacter strain B3728 containing the inhibitors xylitol and D-sorbitol at 2.5 A and 2.3 A resolution, respectively. (1990) (90)
- Atomic CO-ordinates for tosyl-α-chymotrypsin (1969) (90)
- More of the catalytic triad (1990) (90)
- Analysis of Enzyme Structure and Activity by Protein Engineering (1984) (86)
- The use of x-ray diffraction in the study of protein and nucleic acid structure. (1965) (84)
- Direct Methods In Crystallography (1962) (82)
- The Structure of $\alpha$ -Chymotrypsin (1970) (80)
- Observations of reaction intermediates and the mechanism of aldose-ketose interconversion by D-xylose isomerase. (1990) (77)
- Determination of phases by the conditions of non-crystallographic symmetry (1963) (77)
- 6 The Structure of Chymotrypsin (1971) (72)
- An X-ray diffraction study of inhibited derivatives of α-chymotrypsin (1966) (63)
- The arrangement of α-chymotrypsin molecules in the monoclinic crystal form (1964) (61)
- Binding of tyrosine, adenosine triphosphate and analogues to crystalline tyrosyl transfer RNA synthetase. (1978) (56)
- So do we understand how enzymes work? (2000) (55)
- Rearrangement of Cruickshank's formulae for the diffraction-component precision index. (2002) (55)
- The study of alpha-chymotrypsin by x-ray diffraction. The Third CIBA Medal Lecture. (1969) (55)
- Structural homology in the amino-terminal domains of two aminoacyl-tRNA synthetases. (1983) (54)
- Lipases reach the surface (1991) (54)
- Structural Studies on Molecules of Biological Interest: A volume in honour of Professor Dorothy Hodgkin Edited by Guy Dodson, Jenny P. Glusker and David Sayre Clarendon Press; Oxford, 1981 (1983) (46)
- The tortuous story of Asp…His…Ser: Structural analysis of α-chymotrypsin (1997) (46)
- To fit a plane to a set of points by least squares (1960) (45)
- Letter: Crystallization and preliminary x-ray diffraction studies on tyrosyl-transfer RNA synthetase from Bacillus stearothermophilus. (1973) (43)
- -Chymotrypsin: what can we learn about catalysis from x-ray diffraction? (1972) (42)
- Structure of α-chymotrypsin refined at 1.68 Å resolution☆ (1985) (40)
- Phase diagram and dilution experiments in the crystallization of carboxypeptidase G2. (1994) (39)
- Amino acid activation in crystalline tyrosyl-tRNA synthetase from Bacillus stearothermophilus. (1981) (39)
- Control of nucleation of protein crystals (1994) (36)
- Parameter refinement in the multiple isomorphous‐replacement method (1973) (34)
- The relative positions of independent molecules within the same asymmetric unit (1964) (34)
- Control of nucleation in the crystallization of lysozyme (1993) (34)
- The refinement of structures partially determined by the isomorphous replacement method (1961) (33)
- Crystallogenesis studies in microgravity with the Advanced Protein Crystallization Facility on SpaceHab-01 (1997) (32)
- Solubility of glucose isomerase in ammonium sulphate solutions (1988) (31)
- Three-dimensional structure of tosyl-alpha-chymotrypsin. (1967) (31)
- Comparison of backbone structures of glucose isomerase from Streptomyces and Arthrobacter. (1988) (28)
- Structure of the Kunitz-type soybean trypsin inhibitor (STI): implication for the interactions between members of the STI family and tissue-plasminogen activator. (1998) (28)
- Anomeric specificity of D-xylose isomerase. (1992) (28)
- A means of promoting heavy-atom binding in protein crystals. (1965) (28)
- The Structure of haemoglobin - VII. Determination of phase angles in the non-centrosymmetric [100] zone (1958) (27)
- Structure of a mutant of tyrosyl-tRNA synthetase with enhanced catalytic properties (1987) (24)
- Structure and mechanism of D-xylose isomerase. (1992) (23)
- Structure and Substrate Specificity in the Serine Enzymes (1974) (22)
- A density-modification method for the improvement of poorly resolved protein electron-density maps (1982) (20)
- Structure of crystalline methyl-chymotrypsin. (1972) (18)
- Many crystal forms of human immunodeficiency virus reverse transcriptase. (1991) (18)
- Structure of crystalline alpha-chymotrypsin. 3. Crystallographic studies of substrates and inhibitors bound to the active site of alpha-chymotrypsin. (1969) (17)
- Solution of the phase equations representing non-crystallographic symmetry (1964) (15)
- Stereochemistry of Substrate Binding and Hydrolysis in the Trypsin Family of Enzymes (1974) (13)
- The peptide chain of tyrosyl tRNA synthetase: no evidence for a super-secondary structure of four alpha-helices. (1977) (13)
- The tortuous story of Asp ... His ... Ser: structural analysis of alpha-chymotrypsin. (1997) (12)
- Interaction of crystalline tyrosyl-tRNA synthetase with adenosine, adenosine monophosphate, adenosine triphosphate and pyrophosphate in the presence of tyrosinol. (1984) (12)
- Enzyme substrate and inhibitor interactions. (1975) (12)
- How Bijvoet made the difference: the growing power of anomalous scattering. (2003) (12)
- The Mode of Action of Soybean Trypsin Inhibitor as Revealed by Crystal Structure Analysis of the Complex with Porcine Trypsin (1974) (10)
- Molecular mechanics simulations of a conformational rearrangement of D‐xylose in the active site of D‐xylose isomerase (1992) (10)
- A Method for Refinement of Partially Interpreted Protein Structures Including a Procedure for Scaling Between a Model and an Electron-Density Map (1983) (10)
- A novel spin filter method for the measurement of solubility (2001) (10)
- Enzymology. More of the catalytic triad. (1990) (9)
- Arthrobacter D-xylose isomerase: protein-engineered subunit interfaces. (1993) (9)
- Trigonal crystals of glucose isomerase require thymol for their growth and stability (1989) (9)
- Molecular structure: Computer cues to combat hypertension (1983) (8)
- New books - The use of X-ray diffraction in the study of protein and nucleic acid structure (1966) (8)
- The single isomorphous replacement method. A correction (1962) (8)
- CRYSTALLINE FORMS OF CYTOCHROME C. (1964) (7)
- On the correlation between three-dimensional structure and reactivity for a series of locked substrates of chymotrypsin. (1976) (6)
- Conventional X-ray diffraction approaches to the study of enzyme mechanism: serine proteinases, aminoacyl-tRNA synthetases and xylose isomerase (1992) (6)
- SOYBEAN TRYPSIN INHIBITOR (1998) (5)
- The molecular approach to biology (1962) (5)
- An X-ray examination of some crystal forms of pig and rabbit haemoglobin (1958) (5)
- Chymotrypsin: tertiary structure and enzymic activity. (1968) (4)
- Hard facts on structure: hot air about mobility (1982) (4)
- Crystal structures of two factitious mutants of tyrosyl-tRNA synthetase (1986) (4)
- An x-ray diffraction study of inhibited derivatives of alpha-chymotrypsin. (1966) (3)
- Now you see it, now you don't (1993) (3)
- General Discussion Remark: Energetics of Inhibitor Binding (1974) (3)
- Flexibility and rigidity in protein crystals. (1977) (3)
- X-ray health and safety (1978) (3)
- CRYSTAL STRUCTURE OF CHOLESTEROL OXIDASE COMPLEXED WITH A STEROID SUBSTRATE. IMPLICATIONS FOR FAD DEPENDENT ALCOHOL OXIDASES (1993) (2)
- Genetic dissection of tyrosyl-tRNA synthetase. (1984) (2)
- STRUCTURE OF ALPHA-CHYMOTRYPSIN REFINED AT 1.68 ANGSTROMS RESOLUTION (1985) (2)
- Crystal structure of carboxypeptidase G2and comparison with other zinc-containing exopeptidases (1996) (2)
- THE ARRANGEMENT OF ALPHA-CHYMOTRYPSIN MOLECULES IN THE MONOCLINIC CRYSTAL FORM. (1964) (2)
- Formation of a Helical Complex by a Sulfonphthalein Dye1 (1960) (1)
- Design, construction and properties of novel protein molecules - Introduction (1986) (1)
- XYLOSE ISOMERASE FROM THERMOTOGA NEAPOLITANA (1998) (1)
- STRUCTURAL ANALYSIS OF A SERIES OF MUTANTS OF TYROSYL-TRNA SYNTHETASE: ENHANCEMENT OF CATALYSIS BY HYDROPHOBIC INTERACTIONS (1994) (1)
- I. Serine proteinases. The structure of alpha-chymotrypsin. (1970) (1)
- A survey of costs incurred in UK X-ray diffraction research laboratories as a consequence of proposed regulations for radiological safety (1981) (1)
- CORRELATION BETWEEN THREE-DIMENSIONAL STRUCTURE AND REACTIVITY FOR A SERIES OF LOCKED SUBSTRATES OF CHYMOTRYPSIN (1977) (0)
- Real-time docking system for analysis of enzyme-substrate interactions (1984) (0)
- Encounters with a dark lady (2002) (0)
- Profile No. 18 – BIOPHYSICS (1981) (0)
- The bondage of symmetry broken (2000) (0)
- Crystallization and heavy-atom derivatives for cholesterol oxidase (1987) (0)
- Enzyme catalysis: now you see it, now you don't. (1993) (0)
- CRYSTALLOGRAPHIC STUDIES OF TYROSYL tRNA SYNTHETASE (1980) (0)
- STEROIDS, STEROID-BINDING PROTEINS AND HYDROPHOBIC BINDING SITES (1997) (0)
- Enzyme engineering from crystallographically known structures (1984) (0)
- Institute and Society page (1967) (0)
- Protein crystallography (1977) (0)
- The golden ratio inverted (1986) (0)
- The Laue rapid diffraction technique reveals an ordered water molecule poised to attack the acyl group of an acyl-trypsin analogue of the intermediate in trypsin-catalysed reactions. (1993) (0)
- Prehistory of the British Crystallographic Association (2004) (0)
- Chapter 13.1 Noncrystallographic symmetry (2006) (0)
- XYLOSE ISOMERASE FROM THERMOANAEROBACTERIUM THERMOSULFURIGENES (1998) (0)
- Simulations of a conformational rearrangement of D‐xylose in the active side of D‐xylose isomerase (2008) (0)
- Observations ofreaction intermediates andthemechanism of aldose-ketose interconversion byD-xylose isomerase (1990) (0)
- Crystal structure and enzyme engineering (1988) (0)
- Crystallization studies on HIV-1 reverse transcriptase (1992) (0)
- Saving the Institute money (1972) (0)
- Computer Page: Microprocessors in Schools. (1980) (0)
- Tyrosyl-tRNA synthetase forms a nucleotide binding fold (1981) (0)
- Structure, mechanism and modification of xylose isomerase (2007) (0)
- Site-directed mutagenesis and structural studies to probe and modify enzyme action (1987) (0)
- Design, construction, and properties of novel protein molecules : proceedings of a Royal Society discussion meeting, held on 5 and 6 June 1985 (1986) (0)
- ANALYSIS OF STRUCTURE‐ACTIVITY RELATIONS IN ENZYMES USING PROTEIN ENGINEERING (1984) (0)
- A computer procedure for extension of model electron density for density modification or for refinement purposes (1981) (0)
- Enzymology. Lipases reach the surface. (1991) (0)
- Atomic co-ordinates for tosyl-alpha-chymotrypsin. (1969) (0)
- AIDS and The Sunday Times (1994) (0)
- The Role of Separate Domains and of Individual Amino-Acids in Enzyme Catalysis, Studied by Site-Directed Mutagenesis (1987) (0)
- XYLOSE ISOMERASE FROM BACILLUS STEAROTHERMOPHILUS (1998) (0)
- Protein structures without heavy atoms (1975) (0)
- Breasting the flood (1992) (0)
- The crystal structure of cholesterol oxidase complexed with a dehydroisoandrosterone substrate at 1.9 Å resolution (1993) (0)
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