David Orville Toft
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David Orville Toftbiology Degrees
Biology
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#10945
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Molecular Biology
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Biochemistry
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Biology
David Orville Toft's Degrees
- PhD Biochemistry Stanford University
- Bachelors Chemistry University of California, Berkeley
Why Is David Orville Toft Influential?
(Suggest an Edit or Addition)David Orville Toft's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Steroid receptor interactions with heat shock protein and immunophilin chaperones. (1997) (1745)
- Regulation of Signaling Protein Function and Trafficking by the hsp90/hsp70-Based Chaperone Machinery 1 (2003) (1487)
- HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. (2005) (1049)
- A receptor molecule for estrogens: isolation from the rat uterus and preliminary characterization. (1966) (744)
- Functional requirement of p23 and Hsp90 in telomerase complexes. (1999) (572)
- The Amino-terminal Domain of Heat Shock Protein 90 (hsp90) That Binds Geldanamycin Is an ATP/ADP Switch Domain That Regulates hsp90 Conformation* (1997) (559)
- Hormone receptors: studies on the interaction of estrogen with the uterus. (1968) (529)
- Steroid receptors and their associated proteins. (1993) (510)
- An acetylation site in the middle domain of Hsp90 regulates chaperone function. (2007) (404)
- Evidence that the 90-kDa phosphoprotein associated with the untransformed L-cell glucocorticoid receptor is a murine heat shock protein. (1985) (398)
- Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin. (1998) (396)
- Molecular Chaperone Machines: Chaperone Activities of the Cyclophilin Cyp-40 and the Steroid Aporeceptor-Associated Protein p23 (1996) (373)
- The hsp90-related Protein TRAP1 Is a Mitochondrial Protein with Distinct Functional Properties* (2000) (359)
- Hop Modulates hsp70/hsp90 Interactions in Protein Folding* (1998) (352)
- The Hsp90 chaperone complex as a novel target for cancer therapy. (2003) (343)
- Hepadnavirus assembly and reverse transcription require a multi‐component chaperone complex which is incorporated into nucleocapsids (1997) (323)
- Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer. (2005) (269)
- Identification of a 60-kilodalton stress-related protein, p60, which interacts with hsp90 and hsp70 (1993) (267)
- Response of human breast cancer cells to heat shock and chemotherapeutic drugs. (1992) (253)
- A 90,000-dalton binding protein common to both steroid receptors and the Rous sarcoma virus transforming protein, pp60v-src. (1985) (248)
- The Assembly of Progesterone Receptor-hsp90 Complexes Using Purified Proteins* (1998) (245)
- A novel chaperone complex for steroid receptors involving heat shock proteins, immunophilins, and p23. (1994) (241)
- Nucleotides and Two Functional States of hsp90* (1997) (240)
- The Importance of ATP Binding and Hydrolysis by Hsp90 in Formation and Function of Protein Heterocomplexes* (1999) (233)
- Molecular cloning of the chicken progesterone receptor (1986) (230)
- Progesterone binding in the mouse and rat uterus. (1972) (220)
- Relationship of the 90-kDa murine heat shock protein to the untransformed and transformed states of the L cell glucocorticoid receptor. (1987) (217)
- Inhibition of progesterone receptor activation by sodium molybdate. (1980) (205)
- Binding of p23 and hsp90 during assembly with the progesterone receptor. (1995) (204)
- Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes (1994) (202)
- A receptor molecule for estrogens: studies using a cell-free system. (1967) (199)
- Purification of unactivated progesterone receptor and identification of novel receptor-associated proteins. (1990) (198)
- A specific progesterone receptor in the hamster uterus: physiologic properties and regulation during the estrous cycle. (1974) (194)
- The A and B forms of the chicken progesterone receptor arise by alternate initiation of translation of a unique mRNA. (1987) (193)
- The Assembly and Intermolecular Properties of the hsp70-Hop-hsp90 Molecular Chaperone Complex* (2002) (188)
- Binding of steroids to progesterone receptor proteins in chick oviduct and human uterus. (1974) (188)
- Differential interactions of p23 and the TPR-containing proteins Hop, Cyp40, FKBP52 and FKBP51 with Hsp90 mutants. (1998) (184)
- Requirement of Heat Shock Protein 90 for Human Hepatitis B Virus Reverse Transcriptase Function (2004) (179)
- In vitro binding of retinol to rat-tissue components. (1973) (177)
- Hsp90 Inhibition Depletes Chk1 and Sensitizes Tumor Cells to Replication Stress* (2003) (176)
- The p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficacies. (2000) (175)
- Target tissue receptors for progesterone: the influence of estrogen treatment. (1972) (174)
- Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions. (2008) (171)
- Binding of heat shock proteins to the avian progesterone receptor (1989) (167)
- Up-regulation of heat shock protein 27 induces resistance to 17-allylamino-demethoxygeldanamycin through a glutathione-mediated mechanism. (2006) (164)
- Preparation of monoclonal antibodies to the avian progesterone receptor. (1986) (161)
- Assembly of progesterone receptor with heat shock proteins and receptor activation are ATP mediated events. (1992) (160)
- Immunological evidence that the nonhormone binding component of avian steroid receptors exists in a wide range of tissues and species. (1985) (153)
- Dimerization and N-terminal domain proximity underlie the function of the molecular chaperone heat shock protein 90. (2000) (152)
- Molecular chaperones function as steroid receptor nuclear mobility factors. (2004) (151)
- Immunologic analysis of human breast cancer progesterone receptors. 1. Immunoaffinity purification of transformed receptors and production of monoclonal antibodies. (1987) (151)
- Cooperative action of Hsp70, Hsp90, and DnaJ proteins in protein renaturation. (1996) (150)
- FKBP51 Promotes Assembly of the Hsp90 Chaperone Complex and Regulates Androgen Receptor Signaling in Prostate Cancer Cells (2010) (149)
- Polypeptide components of two 8 S forms of chicken oviduct progesterone receptor. (1984) (148)
- Immunocytochemical localization of estrogen-induced progestin receptors in guinea pig brain (1988) (147)
- Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones. (1999) (145)
- HSP40 Binding Is the First Step in the HSP90 Chaperoning Pathway for the Progesterone Receptor* (2002) (144)
- Progesterone "receptors" in the cytoplasm and nucleus of chick oviduct target tissue. (1970) (143)
- Progesterone-binding protein of chick oviduct. VI. Interaction of purified progesterone-receptor components with nuclear constituents. (1972) (140)
- Reconstitution of progesterone receptor with heat shock proteins. (1990) (133)
- ATP-dependent chaperoning activity of reticulocyte lysate. (1994) (132)
- Effect of geldanamycin on androgen receptor function and stability (2002) (125)
- Progesterone-binding components of chick oviduct. VIII. Receptor activation and hormone-dependent binding to purified nuclei. (1975) (123)
- Progesterone-binding components of chick oviduct. II. Nuclear components. (1971) (122)
- Crystal Structure and Activity of Human p23, a Heat Shock Protein 90 Co-chaperone* (2000) (122)
- A Phase I Trial of Twice-Weekly 17-Allylamino-Demethoxy-Geldanamycin in Patients with Advanced Cancer (2006) (121)
- Phosphorylation in vivo of chicken oviduct progesterone receptor. (1982) (117)
- p23, a simple protein with complex activities (2003) (112)
- In Vitro Reconstitution of Functional Hepadnavirus Reverse Transcriptase with Cellular Chaperone Proteins (2002) (109)
- Activity of lapatinib a novel HER2 and EGFR dual kinase inhibitor in human endometrial cancer cells (2008) (108)
- Thiopurine S-methyltransferase pharmacogenetics: chaperone protein association and allozyme degradation. (2003) (105)
- The Influence of ATP and p23 on the Conformation of hsp90* (2002) (100)
- Sequence and expression of a functional chicken progesterone receptor. (1987) (98)
- Chaperoning Checkpoint Kinase 1 (Chk1), an Hsp90 Client, with Purified Chaperones* (2006) (97)
- The involvement of p23, hsp90, and immunophilins in the assembly of progesterone receptor complexes (1996) (82)
- Isolation of steroid receptor binding protein from chicken oviduct and production of monoclonal antibodies. (1985) (82)
- Structures of the N-terminal and middle domains of E. coli Hsp90 and conformation changes upon ADP binding. (2005) (80)
- P-Glycoprotein-mediated resistance to Hsp90-directed therapy is eclipsed by the heat shock response. (2008) (80)
- Chemical modification of the avian progesterone receptor by pyridoxal 5'-phosphate. (1979) (77)
- Characterization of a cytoplasmic receptor for 5alpha-dihydrotestosterone in the caput epididymidis of intact rabbits. (1973) (77)
- Stabilization of the avian progesterone receptor by inhibitors. (1979) (75)
- Defining the Requirements for Hsp40 and Hsp70 in the Hsp90 Chaperone Pathway* (2006) (74)
- Characterization of progesterone receptor binding to the 90- and 70-kDa heat shock proteins. (1991) (71)
- Requirement for activation in the binding of progesterone receptor to ATP-Sepharose. (1978) (71)
- Purification of "nontransformed" avian progesterone receptor and preliminary characterization. (1982) (71)
- Regulation of Heat Shock Protein 90 ATPase Activity by Sequences in the Carboxyl Terminus* (2002) (70)
- Immunocytochemical study of progesterone receptors in the human endometrium during the menstrual cycle. (1988) (68)
- Immunologic analysis of human breast cancer progesterone receptors. 2. Structure, phosphorylation, and processing. (1987) (67)
- Immunofluorescence colocalization of the 90-kDa heat-shock protein and microtubules in interphase and mitotic mammalian cells. (1989) (66)
- Recent Advances in the Study of hsp90 Structure and Mechanism of Action (1998) (66)
- GCUNC-45 Is a Novel Regulator for the Progesterone Receptor/hsp90 Chaperoning Pathway (2006) (65)
- Hormone‐dependent processing of the avian progesterone receptor (1988) (64)
- Mutational analysis of Hsp90 alpha dimerization and subcellular localization: dimer disruption does not impede "in vivo' interaction with estrogen receptor. (1996) (63)
- Identification of the 90 kDa substrate of rat liver type II casein kinase with the heat shock protein which binds steroid receptors. (1987) (63)
- Inhibition of the binding of progesterone receptor to nuclei: effects of o-phenanthroline and rifamycin AF/013. (1975) (63)
- Identification of a complex between centrin and heat shock proteins in CSF-arrested Xenopus oocytes and dissociation of the complex following oocyte activation. (1995) (63)
- The interaction of uterine estrogen receptors with DNA. (1972) (63)
- hsp70 interacting protein Hip does not affect glucocorticoid receptor folding by the hsp90-based chaperone machinery except to oppose the effect of BAG-1. (2000) (62)
- Molecular chaperoning of steroid hormone receptors. (1996) (62)
- Estrogen response in the hFOB 1.19 human fetal osteoblastic cell line stably transfected with the human estrogen receptor gene (1995) (60)
- Cisplatin abrogates the geldanamycin-induced heat shock response (2008) (60)
- Analysis of the steroid receptor of Achlya ambisexualis. (1984) (60)
- Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70 (2004) (59)
- In situ localization of progesterone receptors in normal mouse mammary glands: Absence of receptors in the connective and adipose stroma and a heterogeneous distribution in the epithelium (1997) (59)
- Mutational analysis of hsp90 binding to the progesterone receptor. (1993) (59)
- Transformation of mammary cytoplasmic glucocorticoid receptor under cell-free conditions. (1981) (58)
- P59 (FK506 binding protein 59) interaction with heat shock proteins is highly conserved and may involve proteins other than steroid receptors. (1993) (54)
- Hsp90: from structure to phenotype (2004) (53)
- Loss of proliferative potential during terminal differentiation coincides with the decreased abundance of a subset of heterogeneous ribonuclear proteins (1989) (53)
- Glucocorticoid receptors in pituitary tumor cells. I. Cytosol receptors. (1973) (49)
- GCUNC45 Is the First Hsp90 Co-chaperone to Show α/β Isoform Specificity* (2008) (48)
- Structure-function properties of the chicken progesterone receptor A synthesized from complementary deoxyribonucleic acid. (1987) (48)
- HSP70 and HSP90 expression in leucocytes after exercise in moderately trained humans. (2002) (47)
- Characterization of two 8 S forms of chick oviduct progesterone receptor. (1982) (47)
- Inactivation of avian progesterone receptor binding to ATP-Sepharose by pyridoxal 5'-phosphate. (1978) (47)
- The production of antibodies against the conserved cysteine region of steroid receptors and their use in characterizing the avian progesterone receptor. (1988) (44)
- Interaction of the progesterone receptor with binding proteins for FK506 and cyclosporin A. (1995) (44)
- Hormone-dependent phosphorylation of the avian progesterone receptor. (1988) (43)
- Binding of ATP to the progesterone receptor. (1975) (43)
- Role of the cochaperone Tpr2 in Hsp90 chaperoning. (2008) (42)
- Detection of a pheromone-binding protein in the aquatic fungus Achlya ambisexualis. (1984) (39)
- Estrogen receptors in the chick oviduct. (1975) (39)
- Phase I study of 17-allylamino-17 demethoxygeldanamycin, gemcitabine and/or cisplatin in patients with refractory solid tumors (2011) (39)
- Receptors for glucocorticoids in lung tissue. (1973) (38)
- Glucocorticoid receptors in mouse pituitary tumor cells. II. Nuclear binding. (1974) (32)
- An improved method for the measurement of 1,25-(OH)2D3 in human plasma. (1978) (31)
- Corticoid binding component in rat brain (1972) (31)
- Open-label, dose-escalation, safety, pharmacokinetic, and pharmacodynamic study of intravenously administered CNF1010 (17-(allylamino)-17-demethoxygeldanamycin [17-AAG]) in patients with solid tumors (2013) (29)
- ArticleHDAC 6 Regulates Hsp 90 Acetylation and Chaperone-Dependent Activation of Glucocorticoid Receptor (2005) (29)
- Functioning of the Hsp90 machine in chaperoning checkpoint kinase 1 (Chk1) and the progesterone receptor (PR) (2007) (28)
- [14] Receptor identification by density gradient centrifugation (1975) (27)
- Analysis of Hsp90 cochaperone interactions reveals a novel mechanism for TPR protein recognition. (2008) (26)
- Binding of ATP to Progesterone Receptors: Properties and Functional Significance of This Interaction * (1977) (25)
- The properties and functional significance of ATP binding to progesterone receptors. (1976) (25)
- Interaction of progesterone receptor with immobilized adenosine triphosphate. (1977) (24)
- A phase I trial of 17-allylamino-geldanamycin (17AAG) in patients with advanced cancer. (2004) (24)
- A new affinity resin for purification of non-transformed avian progesterone receptor. (1982) (24)
- Transformation of highly purified avian progesterone receptor. (1984) (23)
- Immunocytochemical study of progesterone receptors in hyperplastic and neoplastic endometrial tissues. (1988) (22)
- Composition, assembly and activation of the avian progesterone receptor (1992) (22)
- Characterization and physiological variation of estrogen receptors in rabbit corpora lutea throughout pregnancy and pseudopregnancy: the effect of hysterectomy and sustained estradiol treatment. (1983) (21)
- Studies with antibodies against the conserved cysteine region of progesterone receptor. (1988) (21)
- Interaction of murine progesterone receptors with specific monoclonal antibodies to the avian progesterone receptor. (1988) (19)
- Nuclease resistance and the enrichment of native nuclear acceptor sites for the avian oviduct progesterone receptor. (1986) (19)
- Accelerated recovery of postischemic stunned myocardium after induced expression of myocardial heat-shock protein (HSP70). (1995) (18)
- The interaction of uterine estrogen receptors with DNA. (1972) (18)
- Peptide mapping analysis of the avian progesterone receptor. (1986) (18)
- The avian progesterone receptor: isolation and characterization of phosphorylated forms. (1984) (17)
- ATP-PPi exchange activity of progesterone receptor. (1976) (17)
- A Specific Oviduct Target-Tissue Receptor For Progesterone: Identification, Characterization, Partial Purification, Inter-Compartmental Transfer Kinetics and Specific Interaction with the Genome (1971) (17)
- Inhibition of progesterone receptor activation by vanadate. (1980) (17)
- Characterization of plant p23-like proteins for their co-chaperone activities (2010) (16)
- Progesterone-induced avidin as a marker of cytodifferentiation in the oviduct: comparison to ovalbumin. (1990) (16)
- Phosphorylation of steroid receptors (1985) (16)
- Testosterone binding in the chick oviduct. (1973) (15)
- A Novel In Situ Assay for the Identification and Characterization of Soluble Nuclear Mobility Factors (2004) (15)
- A distinction between 3-methylcholanthrene and estrogen binding in the uterus. (1972) (14)
- Hsp90-containing multiprotein complexes in the eukaryotic microbe Achlya. (1998) (14)
- Concentration of cytosolic estrogen receptors in patients with postmenopausal osteoporosis. (1980) (14)
- Radiochemical probes for steroid hormone receptors. (1982) (12)
- Binding of chemical carcinogens in the lung. (1974) (11)
- Characterization of the avian progesterone receptor through the use of inhibitors. (1979) (11)
- A method of sequencing without subcloning and its application to the identification of a novel ORF with a sequence suggestive of a transcriptional regulator in the water mold Achlya ambisexualis. (1990) (10)
- Novel activation step required for transcriptional competence of progesterone receptor on chromatin templates. (2003) (10)
- A phase I trial of gemcitabine (Gem), 17-allylaminogeldanamycin (17-AAG) and cisplatin (CDDP) in solid tumor patients. (2004) (10)
- Receptor identification by density gradient centrifugation. (1975) (10)
- Effect of culture medium composition on pheromone receptor levels in Achlya ambisexualis. (1985) (8)
- Characterization of an unusual sex steroid binding component from the chicken oviduct. (1984) (8)
- Chapter 7 – HEAT SHOCK PROTEINS AND STEROID HORMONE RECEPTORS (1987) (8)
- Phase I study of CNF1010 (lipid formulation of 17-(allylamino)-17-demethoxygeldanamycin: 17-AAG) in patients with advanced solid tumors. (2006) (8)
- Interrelationships of nuclear and cytoplasmic estrogen receptors. (1969) (7)
- Biological response of the female strain Achlya ambisexualis 734 to dehydro-oogoniol and analogues (1993) (7)
- Analysis of the Avian Progesterone Receptor with Inhibitors (1980) (5)
- Thiopurine S‐Methyltransferase (TPMT) Pharmacogenetics: Role of Chaperone Proteins in variant Allozyme Degradation (2003) (5)
- In Vitro Assembly of the Avian Progesterone Receptor (1994) (5)
- Purification of Nontransformed Avian Progesterone Receptor (1990) (4)
- Progesterone receptor concentration differences in the chick oviduct cells and apparent down-regulation by ligand. A semiquantitative immunohistochemical study. (1989) (4)
- ATP sensitive tryptophans of hsp90. (1998) (4)
- Mechanism of sex steroid action. (1967) (4)
- Synthesis of highly tritiated 7-deoxy-7 dihydroantheridiol and antheriodiol† (1987) (4)
- A Sex Steroid Receptor in the Water Mold Achlya ambisexualis (1986) (2)
- Interaction of chick oviduct progesterone receptor with the 2',3'-dialdehyde derivative of adenosine 5'-triphosphate. (1983) (2)
- Immunological Analysis of the Avian Progesterone Receptor (1987) (2)
- A phase I trial of gemcitabine (Gem), 17-allylaminogeldanamycin (17-AAG) and cisplatin (CDDP) in solid tumor patients (2004) (2)
- Testicular Feminization Syndrome: A Model of Chemical Information Non-Transfer (1975) (1)
- Progesterone-binding Protein of Chick Oviduct (2003) (1)
- Immunocytochemical study of estrogen (ER) and progesterone receptors (PgR) in hyperplastic and neoplastic human endometria (1988) (1)
- Vasoactive intestinal peptide (VIP): Binding in different organs in the rat (1978) (1)
- Resistance due to the stress response surpasses the contribution of P-glycoprotein mediated resistance to HSP90-targeted therapy (2007) (1)
- Partners in surveillance and quality control (2008) (0)
- The Interaction of Estrogens With a Receptor Molecule From The Rat Uterus (1967) (0)
- Phosphorylation of the Avian Progesterone Receptor (2018) (0)
- Steroid hormone regulation of the achlya 85kd heat shock protein which is a component of the achlya steroid receptor (1989) (0)
- of lapatinib a novel HER2 and EGFR dual kinase inhibitor in human endometrial cancer cells. (2008) (0)
- Vasoactive intestinal polypeptide (VIP): Comparative effect on cyclic nucleotide system in liver and pancreas (1978) (0)
- Hsp90: a chaperone for protein kinases and hormone receptors (2007) (0)
- Conformation rearrangement of heat shock protein 90 upon ADP binding (2005) (0)
- CRYSTAL STRUCTURE OF THE HUMAN CO-CHAPERONE P23 (2000) (0)
- Book Review:Steroid-Protein Interactions. Monographs on Endocrinology, Volume 4. U. Westphal (1972) (0)
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What Schools Are Affiliated With David Orville Toft?
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