Donald Selwyn Davies

Donald Selwyn Davies's AcademicInfluence.com Rankings

Medical

#2709

World Rank

#3140

Historical Rank

Pharmacology

#300

World Rank

#349

Historical Rank

medical Degrees

Download Badge

Medical

Donald Selwyn Davies's Degrees

PhD Pharmacology University of Oxford

Why Is Donald Selwyn Davies Influential?

(Suggest an Edit or Addition)

(See a Problem?)

Donald Selwyn Davies's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Pharmacokinetics and metabolism of budesonide, a selective glucocorticoid. (1982) (307)
Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man. (1990) (284)
Mechanisms of cell death. (1989) (281)
Pharmacokinetics and concentration‐effect relationships of intravenous and oral clonidine (1977) (267)
CYP1A2-catalyzed conversion of dietary heterocyclic amines to their proximate carcinogens is their major route of metabolism in humans. (1994) (259)
Meta-analysis of Studies of Alcohol and Breast Cancer with Consideration of the Methodological Issues (2006) (252)
A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette smoking. (1988) (250)
Investigations into the mechanism by which sulfated polysaccharides inhibit HIV infection in vitro. (1992) (173)
Monooxygenase activity of human liver in microsomal fractions of needle biopsy specimens. (1980) (153)
Development of a comprehensive panel of antibodies against the major xenobiotic metabolising forms of cytochrome P450 in humans. (1998) (150)
CLONIDINE WITHDRAWAL IN HYPERTENSION Changes in Blood-pressure and Plasma and Urinary Noradrenaline (1977) (136)
Contribution of CYP1A1 and CYP1A2 to the activation of heterocyclic amines in monkeys and human. (1994) (131)
The specificity of inhibition of debrisoquine 4-hydroxylase activity by quinidine and quinine in the rat is the inverse of that in man. (1989) (131)
Intra- and interindividual variability in systemic exposure in humans to 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline and 2-amino-1-methyl- 6-phenylimidazo[4,5-b]pyridine, carcinogens present in cooked beef. (1992) (120)
Isoprenaline resistance and the use of pressurised aerosols in asthma. (1968) (111)
Distribution and induction of CYP3A1 and CYP3A2 in rat liver and extrahepatic tissues. (1995) (109)
Human cytochromes P-450. (1984) (106)
Species and sex differences in electron transport systems in liver microsomes and their relationship to ethylmorphine demethylation. (1969) (106)
Immunocytochemical localization of cytochrome P-450 in hepatic and extra-hepatic tissues of the rat with a monoclonal antibody against cytochrome P-450 c. (1986) (104)
Quinidine and the identification of drugs whose elimination is impaired in subjects classified as poor metabolizers of debrisoquine. (1986) (101)
Detection and measurement of MeIQx in human urine after ingestion of a cooked meat meal. (1989) (99)
Evidence for an enzymatic defect in the 4-hydroxylation of debrisoquine by human liver. (1981) (95)
Kinetics of Icodextrin (1994) (94)
Changes in liver blood flow during enzyme induction. (1971) (93)
Species differences in the hepatotoxicity of paracetamol are due to differences in the rate of conversion to its cytotoxic metabolite. (1987) (92)
Nucleosomes Bind to Cell Surface Proteoglycans* (1999) (92)
Fluorescence studies on some hydroxypyridines including compounds of the vitamin B6 group. (1966) (92)
Effects of clonidine on biochemical indices of sympathetic function and plasma renin activity in normotensive man. (1977) (88)
Biphasic O-deethylation of phenacetin and 7-ethoxycoumarin by human and rat liver microsomal fractions. (1981) (88)
Reversal of acetaminophen toxicity in isolated hamster hepatocytes by dithiothreitol. (1986) (87)
Metabolism of the food derived mutagen and carcinogen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) by human liver microsomes. (1994) (85)
Sex differences in the kinetic constants for the N-demethylation of ethylmorphine by rat liver microsomes. (1968) (83)
Kinetics of paraquat elimination in the dog. (1981) (81)
Comparison of the in vivo and in vitro rates of formation of the three main oxidative metabolites of antipyrine in man. (1981) (81)
Assessment of antipyrine kinetics by measurement in saliva. (1976) (77)
Extra-nuclear location of histones in activated human peripheral blood lymphocytes and cultured T-cells. (1995) (77)
Measurement of MeIQx and DiMeIQx in fried beef by capillary column gas chromatography electron capture negative ion chemical ionisation mass spectrometry. (1988) (75)
Human hepatic CYP1A1 and CYP1A2 content, determined with specific anti-peptide antibodies, correlates with the mutagenic activation of PhIP. (1993) (75)
The inducibility and catalytic activity of cytochromes P450c (P450IA1) and P450d (P450IA2) in rat tissues. (1990) (73)
Substrate specificity of the form of cytochrome P-450 catalyzing the 4-hydroxylation of debrisoquine in man. (1983) (72)
Dose‐dependent enzyme induction (1973) (72)
Mechanisms of cell death (2005) (70)
ACCELERATED PAPER: Mutational spectra of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) at the Chinese hamster hprt locus (1996) (70)
MECHANISM OF HEPATIC DRUG OXIDATION AND ITS RELATIONSHIP TO INDIVIDUAL DIFFERENCES IN RATES OF OXIDATION IN MAN * (1971) (70)
Identification and location of alpha-helices in mammalian cytochromes P450. (1989) (69)
Assay and characterisation of debrisoquine 4-hydroxylase activity of microsomal fractions of human liver. (1982) (66)
Quantitative determination of the herbicide paraquat in human plasma by gas chromatographic and mass spectrometric methods. (1977) (64)
Genetic polymorphism in drug oxidation: in vitro studies of human debrisoquine 4-hydroxylase and bufuralol 1'-hydroxylase activities. (1985) (64)
Blood concentrations in man of fluorinated hydrocarbons after inhalation of pressurised aerosols. (1970) (61)
Interindividual variation in kinetics of infused epinephrine (1979) (61)
Food-derived heterocyclic amine mutagens: variable metabolism and significance to humans. (2001) (61)
Metabolism of isoprenaline in the intestine (1974) (61)
The cardiac effects of terfenadine after inhibition of its metabolism by grapefruit juice (1997) (60)
Drug interactions with warfarin: studies with dichloralphenazone, chloral hydrate and phenazone (antipyrine). (1971) (57)
Sex and strain differences in hepatic debrisoquine 4-hydroxylase activity of the rat. (1985) (57)
Tissue and species differences in enzymes of epoxide metabolism. (1981) (57)
Determination of human hepatic cytochrome P4501A2 activity in vitro use of tacrine as an isoenzyme-specific probe. (1995) (55)
Pharmacokinetics of inhaled substances. (1975) (54)
Interindividual differences in rates of drug oxidation in man. (1973) (53)
Freshly isolated hepatocytes as a model for studying the toxicity of paracetamol. (1986) (53)
Paracetamol oxidation: synthesis and reactivity of N-acetyl-p-benzoquinoneimine (1981) (53)
Short synthetic peptides exploited for reliable and specific targeting of antibodies to the C-termini of cytochrome P450 enzymes. (1995) (51)
High affinity phenacetin O-deethylase is catalysed specifically by cytochrome P450d (P450IA2) in the liver of the rat. (1990) (50)
Immunohistochemical localization of cytochrome P450b/e in hepatic and extrahepatic tissues of the rat. (1989) (49)
Xenobiotic metabolism in the human lung. (1980) (49)
Evidence for a direct role of intracellular calcium in paracetamol toxicity. (1990) (47)
The fate of ethyltin and diethyltin derivatives in the rat. (1967) (46)
N-hydroxy-MeIQx is the major microsomal oxidation product of the dietary carcinogen MeIQx with human liver. (1992) (46)
Determination of the N-acetyl metabolites of 4,4'-methylene dianiline and 4,4'-methylene-bis(2-chloroaniline) in urine. (1988) (46)
Heterocyclic amines: evaluation of their role in diet associated human cancer. (2003) (44)
Infection by HIV‐1 blocked by binding of dextrin 2‐sulphate to the cell surface of activated human peripheral blood mononuclear cells and cultured T‐cells (1994) (44)
Metabolism of terbutaline in man and dog. (1974) (44)
Debrisoquine oxidation phenotype and susceptibility to lung cancer. (1990) (43)
Genetic analysis of PHIP intestinal mutations in MutaMouse. (1998) (42)
Polymorphic metabolism of the carcinogen 2-acetylaminofluorene in human liver microsomes. (1985) (42)
Interaction of the transactivating protein HIV-1 tat with sulphated polysaccharides. (1999) (42)
Apparent resistance to hypotensive effect of clonidine. (1977) (41)
Assessing human risk to heterocyclic amines. (1997) (41)
The effect of monoamine oxidase inhibitors on 'first-pass' metabolism of tyramine in dog intestine. (1980) (40)
Antibodies to a synthetic peptide that react specifically with a common surface region on two hydrocarbon-inducible isoenzymes of cytochrome P-450 in the rat. (1988) (40)
Biological effects of drugs in relation to their plasma concentrations : proceedings of a symposium held by the British Pharmacological Society at the Royal Postrgraduate Medical School, London, on January 4, 1972 (1973) (39)
Phenacetin O-deethylase: an activity of a cytochrome P-450 showing genetic linkage with that catalysing the 4-hydroxylation of debrisoquine? (1985) (38)
Lower levels of urinary 2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline (MeIQx) in humans with higher CYP1A2 activity. (1995) (38)
The metabolism of sympathomimetic bronchodilator drugs by the isolated perfused dog lung. (1973) (36)
Drug metabolising activity of freshly isolated human hepatocytes. (1985) (36)
Mutagenesis of mouse intestine in vivo using the Dlb-1 specific locus test: studies with 1,2-dimethylhydrazine, dimethylnitrosamine, and the dietary mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline. (1990) (36)
Mutational spectra of the dietary carcinogen 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine(PhIP) at the Chinese hamsters hprt locus. (1996) (36)
Pharmacokinetic and concentration-effect relationships of clonidine in essential hypertension (1977) (36)
Plasma concentration of phenylbutazone and its therapeutic effect-studies in patients with rheumatoid arthritis. (1976) (35)
Reduction of the viral load of HIV‐1 after the intraperitoneal administration of dextrin 2‐sulphate in patients with AIDS (1998) (34)
Bufuralol 1'-hydroxylase activity of the rat. Strain differences and the effects of inhibitors. (1986) (34)
14C-antipyrine as a model compound in the study of drug oxidation and enzyme induction in individual surviving rats. (2009) (34)
Dextrin Sulphate and Fucoidan are Potent Inhibitors of HIV Infection in vitro (1991) (32)
An anti-peptide antibody targeted to a specific region of rat cytochrome P-450IA2 inhibits enzyme activity. (1990) (32)
Anti-HIV type 1 activity of sulfated derivatives of dextrin against primary viral isolates of HIV type 1 in lymphocytes and monocyte-derived macrophages. (1997) (32)
Identification of the epitope of an anti-peptide antibody which binds to CYP1A2 in many species including man. (1993) (31)
Induction of mixed function oxidase activity in man by rifapentine (MDL 473), a long-acting rifamycin derivative. (1986) (30)
Rapid tolerance to the hypotensive effects of glyceryl trinitrate in the rat: prevention by N‐acetyl‐l‐ but not N‐acetyl‐d‐cysteine (1990) (30)
Competition for sulphate during detoxification in the gut wall (1975) (29)
Individual differences in the plasma half-lives of lipid soluble drugs in man. (2009) (29)
Dissecting the function of cytochrome P450. (2003) (29)
Differential effects of 3-methylcholanthrene and phenobarbitone treatment on the oxidative metabolism of antipyrine in vitro by microsomal fractions of rat liver. (1982) (29)
Molecular dosimetry of the food-borne carcinogen MeIQx using adducts of serum albumin. (1993) (29)
Trp-P-2 is not detectable in cooked meat and fish. (1987) (28)
Centrally acting drugs in antihypertensive therapy. (1980) (28)
The influence of the route of administration on urinary metabolites of isoetharine. (1974) (28)
Dose and concentration-effect relations for rilmenidine. (1988) (27)
The measurement of MeIQx adducts with mouse haemoglobin in vitro and in vivo: implications for human dosimetry. (1991) (26)
958. Radical-capture agents in tetralin. Measurement of relative efficiencies and correlation with structure (1956) (26)
Sandmeyer and related reactions (1952) (26)
Inter-relatedness of some isoenzymes of cytochrome P-450 from rat, rabbit and human, determined with monoclonal antibodies. (1986) (25)
Identification of a functionally conserved surface region of rat cytochromes P450IA. (1991) (24)
Selective induction and inhibition of the components of 7-ethoxycoumarin O-deethylase activity in the rat. (1986) (24)
A non-enzymic procedure for the quantitative analysis of (3-methoxy-4-sulphoxyphenyl)ethylene glycol (MHPG sulphate) in human urine using stable isotope dilution and gas chromatography—mass spectrometry (1977) (24)
A monoclonal antibody raised to rat liver cytochrome P-448 (form C) which recognises an epitope common to many other forms of cytochrome P-450. (1985) (24)
The metabolism of phenylbutazone in the rat. (1974) (23)
“First‐pass” metabolism of paracetamol in rat liver (1974) (23)
Inhibition of cytochrome P-450-dependent oxidation reactions by MAO inhibitors in rat liver microsomes. (1987) (23)
Cross-reaction of antibodies to coupling groups used in the production of anti-peptide antibodies. (1989) (23)
Relationship between oxidative metabolism of 2-acetylaminofluorene, debrisoquine, bufuralol, and aldrin in human liver microsomes. (1984) (22)
Inducibility of cytochromes P-450 by dioxin in liver and extrahepatic tissues of the marmoset monkey (Callithrix jacchus). (1996) (22)
Monoclonal antibodies to rabbit liver cytochrome P-448. (1981) (22)
The metabolic fate of DL(7-3H)isoprenaline in man and dog. (1969) (22)
Mechanisms of cell toxicity. (1990) (21)
Selective destruction of cytochrome P-450d and associated monooxygenase activity by carbon tetrachloride in the rat. (1989) (20)
Debrisoquine oxidation phenotype and susceptibility to lung cancer. (1990) (20)
The clinical pharmacology of clonidine: relationship between plasma concentration and pharmacological effect in animals and man. (1980) (20)
Demethylation of 3-O-methyldopa in the rat (1971) (20)
Identification of CYP2E1 in marmoset monkey. (1998) (20)
Enzymic and interindividual differences in the human metabolism of heterocyclic amines. (1996) (20)
Influence of liver disease and environmental factors on hepatic monooxygenase activity in vitro (2004) (20)
N-ACETYLCYSTEINE FOR PARACETAMOL OVERDOSE (1986) (19)
Cytoprotection by iloprost against paracetamol‐induced toxicity in hamster isolated hepatocytes (1992) (19)
Metabolism of propranolol in rat: the fate of the N-isopropyl group. (1973) (19)
The analysis of terbutaline in biological fluids by gas chromatography electron impace mass spectrometry. (1979) (19)
The fate of isoprenaline administered by pressurized aerosols. (1970) (19)
Metabolism of the mutagen MeIQx in vivo: metabolite screening by liquid chromatography-thermospray mass spectrometry. (1987) (18)
Ontogenetic development of the distribution of constitutive and 3-methylcholanthrene-induced CYP1A1 and CYP1A2 in rabbit liver. (1993) (18)
Scavenging of hypochlorous acid by lipoic acid (1991) (18)
Expression and distribution of cholesterol 7α-hydroxylase in rat liver (1995) (17)
In vivo absorption studies with paraquat and diquat in the dog [proceedings]. (1976) (17)
The selective activation of cytochrome P-450 dependent microsomal hydroxylases in human and rat liver microsomes. (1981) (17)
A radiometric high-pressure liquid chromatography assay for the simultaneous determination of the three main oxidative metabolites of antipyrine in studies in vitro. (1981) (16)
Bis(trifluoromethyl)aryl derivatives for drug analysis by gas chromatography electron capture negative ion chemical ionization mass spectrometry. Application to the measurement of low levels of clonidine in plasma. (1984) (16)
Antipyrine as an in vitro probe of mixed function oxidase activity [proceeding]. (1980) (16)
Bistrifluoromethylaryl derivatives for drug analysis by gas chromatography electron capture negative ion chemical ionization mass spectrometry. Application to the measurement of (N-dicyclopropylmethyl)amino-2-oxazoline in plasma. (1985) (16)
Reduction of circulating 25-hydroxyvitamin D by antipyrine. (1979) (16)
Enzymatic studies of the activation of heterocyclic food mutagens in man. (1995) (16)
Free and total 3-methoxy-4-hydroxyphenylethylene glycol in human cerebrospinal fluid: relationship to blood pressure in hypertensives and patients with neuropsychiatric disease. (1977) (16)
Disposition and oxidative metabolism of phenylbutazone in man (2004) (15)
The measurement of clonidine in human plasma and urine by combined gas chromatography mass spectrometry with ammonia chemical ionization. (1981) (15)
Differential induction of antipyrine metabolism by rifampicin (2004) (15)
The potential of acetaminophen as a prodrug in gene-directed enzyme prodrug therapy (2000) (15)
Immunopurification of cytochrome P-448 from microsomal fractions of rabbit liver with retention of metabolic activity. (1982) (14)
Inhibition of dietary mutagen activation by methylxanthines (1988) (14)
Pharmacokinetics of inhaled substances. (1979) (13)
Interindividual Differences in the Activation of Two Hepatic Carcinogens to Mutagens by Human Liver (1986) (13)
A strategy for investigating the CYP superfamily using targeted antibodies is a paradigm for functional genomic studies. (2003) (13)
Amylobarbitone hydroxylation kinetics in small samples of rat and human liver. (1976) (13)
Routes of activation of 4,4′-methylenebis-(2-chloroaniline) and 4,4′-methylenedianiline to bacterial mutagens (1986) (12)
Enoxacin is an inducer of CYP1A2 in rat liver. (1995) (11)
Serial measurements of plasma half-lives and urinary excretion of antipyrine in low-birth-weight infants. (1975) (11)
Specific inhibition of human CYP1A2 using a targeted antibody. (1997) (11)
Molecular aspects of debrisoquine metabolism studied by gas chromatography mass spectrometry with electron capture negative ion chemical ionisation (1983) (10)
Mechanisms and Models in Toxicology (1987) (10)
Phenacetin O-deethylase activity of the rat: strain differences and the effects of enzyme-inducing compounds. (1987) (10)
METABOLISM OF DRUGS ADMINISTERED BY AEROSOL (1975) (10)
Acquired resistance to beta stimulants: a possible explantion for the rise in the asthma death rate in Britain. (1973) (10)
An inhibitory monoclonal anti-protein antibody and an anti-peptide antibody share an epitope on rat cytochrome P-450 enzymes CYP1A1 and CYP1A2. (1993) (10)
Distribution and Elimination of [2-14C]Amino-3, 8-Dimethylimidazo [4, 5-f] quinoxaline in Mice. Analysis by Whole Animal Autoradiography (1991) (10)
Paracetamol toxicity in hamster isolated hepatocytes: The increase in cytosolic calcium accompanies, rather than precedes, loss of viability (2005) (9)
Multiple forms of human cytochrome P-450. (1984) (9)
Acetaminophen toxicity in isolated hepatocytes. (1986) (9)
In vitro studies of induction and inhibition of drug oxidation in man. (1987) (9)
Attempts to phenotype human liver samples in vitro for debrisoquine 4-hydroxylase activity. (1985) (9)
399. The kinetics and mechanism of sulphonation in sulphuric acid (1949) (9)
Letter: Clonidine overdose. (1975) (9)
Dietary heterocyclic amines and human cancer. (1989) (8)
Analysis of terfenadine in human plasma using microbore high-performace liquid chromatography-electrospray ionisation mass spectrometry. (1997) (8)
In vivo studies of gut wall metabolism (1982) (8)
A rapid sensitive assay for glutathione S-epoxidetransferase activity: species differences in the activity of the hepatic enzyme [proceedings]. (1979) (8)
Histones located on the plasma membrane of T-cells. (1994) (8)
Increased oxidation of phenylbutazone during hydrocortisone infusion in man. (1977) (8)
Metabolism and mutagenic activation of 2-acetylaminofluorene by human liver and lung. (1981) (8)
Systemic exposure to dietary heterocyclic amines in man. (1995) (8)
Determination of d-isoproterenol sulphate by high-performance liquid chromatography with amperometric detection. (1984) (8)
Identification of the epitope of a monoclonal antibody which binds to several cytochromes P450 in the CYP1A subfamily. (1992) (8)
The fate of inhaled terbutaline. (1984) (8)
Catecholamine turnover in essential hypertension. (1980) (7)
Comparative activation of aromatic amines to mutagenic metabolites by human and rat liver (1986) (7)
The effect of noradrenaline infusion on blood pressure and plasma noradrenaline following clonidine administration in man [proceedings]. (1977) (7)
Urinary conjugates of 4-hydroxy-3-methoxyphenylethylene glycol do not provide an index of brain amine turnover in man. (1980) (7)
Reduced hepatic expression of CYP7A1 and CYP2C13 in rats with spontaneous hyperlipidaemia. (1998) (7)
Paraquat-stimulated binding of dopa to liver and lung microsomal protein. (1980) (7)
Tissue differences in the ontogeny of inducibility of drug-metabolizing enzymes by 3-methylcholanthrene in the rabbit. (1982) (7)
Paraquat poisoning--possible therapeutic approach. (1975) (6)
Demethylation of 3-O-methyldopa. (1971) (6)
The conduct of initial drug studies in man. (1970) (6)
Pharmacokinetic studies with inhaled drugs. (1982) (6)
The Effect of Clonidine on Biochemical Indices of Sympathetic Function in Normotensive Subjects (1976) (6)
Metabolism of isoprenaline and other bronchodilator drugs in man and dog. (1972) (5)
Kinetic studies of the N-demethylation of ethylmorphine by a cytochrome P-450-dependent enzyme system in human liver microsomes. (1971) (5)
Pharmacokinetic and pharmacological studies with clonidine in normal subjects. (1976) (5)
The metabolic activation of 4,4'-methylene-bis-(2-chlorobenzeneamine) to a bacterial mutagen by hepatic postmitochondrial supernatant from human and other species. (1985) (5)
Specificity and inducibility of cytochrome P-450 catalysing the activation of food-derived mutagenic heterocyclic amines (1991) (5)
S 10. The kinetics and mechanism of the sandmeyer reaction (1949) (5)
Reversed-phase high-performance liquid chromatography and amperometric detection of 3-O-methyl isoprenaline sulphate: application to studies on the presystemic metabolism of d-isoprenaline in man. (1985) (5)
Distribution and Elimination of [14 C]2-Amino-3,8-dimethylimidazo-(4,5-F)quinoxaline (1988) (5)
Cisapride has no effect on antipyrine clearance. (1988) (4)
EVIDENCE FOR MORE THAN ONE FORM OF CYTOCHROME P-450 IN HEPATIC MICROSOMAL FRACTIONS OF HUMAN LIVER SAMPLES (1980) (4)
The effects of amiflamine, a reversible MAO-A inhibitor, on the first pass metabolism of tyramine in dog intestine. (1986) (4)
Mixed function oxidase activity in microsomal fractions of human liver biopsy specimens [proceedings]. (1978) (4)
Conservation of a functionally important surface region between two families of the cytochrome P-450 superfamily. (1993) (4)
Expression and distribution of cholesterol 7 alpha-hydroxylase in rat liver. (1995) (4)
Studies on the metabolic fate of 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) in man [proceedings]. (1977) (4)
Screening methods for measuring liver microsomal enzyme induction by drugs. (1969) (4)
CONJUGATES OF 3-METHOXY-4-HYDROXYPHENYLETHYLENE GLYCOL IN MAN (1979) (4)
Comparative activation of paracetamol in the rat, mouse and man. (1987) (4)
Paracetamol toxicity and its prevention by cytoprotection with iloprost. (1992) (4)
Routes of Administration and Drug Response (1975) (3)
MEASUREMENT OF PLASMA CONCENTRATIONS OF TOLBUTAMIDE BY SIMPLIFIED GAS‐LIQUID CHROMATOGRAPHY* (1974) (3)
Glycogen phosphorylase in fish brain ( Carassius carassius ) during hypoxia (2009) (3)
An assay for 2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline and 2-amino-3,4,8-trimethylimidazo-[4,5-f]quinoxaline in fried beef using capillary column gas chromatography electron capture negative ion chemical ionization mass spectrometry. (1988) (3)
The metabolism of clonidine and related imidazoline derivatives in rat liver [proceedings]. (1978) (3)
Exposure to, and activation of, the food derived mutagenic heterocyclic amine MeIQx. (1990) (3)
Surrogacy in antiviral drug development. (2002) (3)
Pharmacokinetics of terbutaline after oral administration. (1984) (3)
Developmental changes in hepatic activation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in rabbit. (1996) (3)
Lung Parenchymal Changes Due to Ingested Substances (1975) (3)
Strain differences in the metabolic activation of aflatoxin B1 in the rat. (1987) (3)
Resistance to beta-adrenoceptor stimulants and death from bronchial asthma. (1971) (2)
2242 – APPLICATIONS OF STABLE ISOTOPE LABELLING IN STUDIES OF THE PHARMACOKINETICS AND METABOLISM OF CLONIDINE (1978) (2)
Stereoselective excretion of 3-methoxy-4-hydroxyphenylethylene glycol sulphate in the dog (1980) (2)
Ontogeny of expression, inducibility and distribution of cytochromes P-450 forms 4 and 6 in rabbit liver. (1989) (2)
Chemical methods for assessing systemic exposure to dietary heterocyclic amines in man. (1996) (2)
Variants of human microsomal enzymes. (1983) (2)
Differences between hepatic and extrahepatic tissues in the activation of 3 8 dimethyl 3h imidazo 4 5 f quinoxalin 2 amine to a mutagen in the ames salmonella test (1988) (2)
Guanethidine N‐oxidation in human liver microsomes (1987) (2)
Cytochrome P-450 and drug oxidation. (1969) (2)
Bio-medical applications of high performance liquid chromatography (HPLC) with amperometric detection. (1987) (2)
Species differences in the hepatic formation of green pigments following the administration of norethindrone. (1984) (2)
The Role of Cytochrome P-450 LM4 in the Activation of the Dietary Carcinogen MeIQx (1988) (2)
Quantitative analysis of noradrenaline clearance [proceedings]. (1979) (2)
Applications of deuterium labelling in pharmacokinetic and concentration-effect studies of clonidine (1978) (2)
Induction of cytochromes P450 by dioxins in liver and lung of marmoset monkeys (Callithrix jacchus). (1996) (2)
Cytoprotective effects of 16,16-dimethyl prostaglandin E2 on paracetamol toxicity in isolated hepatocytes (1988) (2)
1399 – INTERINDIVIDUAL VARIATION IN NORADRENALINE KINETICS (1978) (2)
Environmental factors affecting monooxygenase activity of microsomal fractions of human liver biopsies [proceedings]. (1979) (2)
The mutational signature of α-hydroxytamoxifen at Hprt locus in Chinese hamster cells (2002) (2)
Is the activation of aflatoxin B1 catalysed by the same form of cytochrome P-450 as that 4-hydroxylating debrisoquine in rat and/or man? (1986) (2)
Pharmacokinetics of [14C]FCE 22891, a penem antibiotic, following oral administration to healthy volunteers (1992) (2)
Immunohistochemical localization of cytochrome P-450 b/e in hepatic and extrahepatic rat tissues (1988) (2)
Species differences in specificity of hydrocarbon-inducible forms of cytochrome P-450. (1989) (1)
Quantitative analysis of (3-methoxy-4-sulphooxyphenyl)ethylene glycol (MHPG sulphate) in human urine. (1985) (1)
Stereoselective excretion of (3-methoxy-4-sulphooxyphenyl)ethylene glycol (MHPG sulphate) in the dog (1980) (1)
Mechanisms and Models in Toxicology: Proceedings of the European Society of Toxicology Meeting Held in Harrogate, May 27-29, 1986 (1987) (1)
Organ-directed toxicity : chemical indices and mechanisms : proceedings of the Symposium on Chemical Indices and Mechanisms of Organ-directed Toxicity, Barcelona, Spain, 4-7 March 1981 (1981) (1)
Paracetamol toxicity: A 40 year odyssey (2007) (1)
Correspondence re: A. M. Lynch et al., Intra- and Interindividual Variability in Systemic Exposure in Humans to 2-Amino-3,8-dimethylimidazo[4,5-f]-quinoxaline and 2-Amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine, Carcinogens Present in Cooked Beef. Cancer Res., 52: 6216–6223, 1992 — Reply (1993) (1)
Induction of drug metabolizing enzymes in man and rat by dichloralphenazone. (1969) (1)
Synthesis of 7α-thiohydroxycholesterol involving the resolution of epimeric thiocholesterols by high-performance liquid chromatography (1989) (1)
Central action of drugs in blood pressure regulation : proceedings of an International Symposium on Central Actions of Drugs in the Regulation of Blood Pressure, under the auspices of the British Pharmacological Society (1975) (1)
1417 – METABOLISM OF DRUGS BY INTESTINAL MUCOSA - EFFECT OF SALICYLAMIDE ON BIO-AVAILABILITY OF ORAL ISOPRENALINE IN DOGS (1977) (1)
Chirality, Drug Metabolism and Action (1990) (1)
Location of binding sites for monoclonal antibodies on cytochrome P-450c (1987) (1)
Maternal Drug Therapy and Enzyme Induction in the Fetus and Newborn (1977) (1)
3,8-Dimethyl-2-nitro-imidazo[4,5-f]quinoxaline(Nitro-MeIQx) is a potent direct-acting mutagen (1989) (1)
Activation of the food carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by hepatocytes (1989) (1)
Chimical methode for assessing systemic exposure to heterocyclle aminee in man (1995) (0)
The effect of budesonide and triamcinolone acetonide on hepatic microsomal testosterone metabolism in the rat. (1992) (0)
An introduction to metabolic and kinetic aspects of toxicological studies. (1988) (0)
Flavin-containing monooxygenase activity in human liver microsomes. (1986) (0)
A formofcytochrome P450inman,orthologous toformdinthe rat, catalyses theO-deethylation ofphenacetin andisinducible bycigarette smoking (1988) (0)
Identification of surface regions of cytochromes P-450 using anti-peptide antibodies. (1989) (0)
The metabolism of N,N'-dimethylclonidine by rat liver microsomes [proceedings]. (1979) (0)
Enzyme induction of drug oxidizing enzymes. (1970) (0)
The role of CYP1A enzymes in murine activation of the cooked food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. (1994) (0)
The Effects of Trimethadione and Its Metabolite on Human Liver Debrisoquine 4-Hydroxylase Activity In Vitro (1990) (0)
Hydronephrosis of Left Kidney Due to Stricture of Pelvi-Ureteral Junction (1927) (0)
Proceedings: Uptake of propranolol by the isolated perfused rat liver. (1974) (0)
Molecular analysis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mutation in the hprt gene (1996) (0)
Antipyrine induction and hepatic vitamin D hydroxylation in man [proceedings]. (1979) (0)
Phenylbutazone: factors influencing plasma concentrations. (1977) (0)
Isozymle and interindividual difference in human metabollsm of heterocyclle aminee (1995) (0)
Effects of Liver Disease and Smoking on Hepatic Mono-Oxygenase Activity in Vitro (1979) (0)
A method for studying drug metabolism in the canine intestine (T) (1974) (0)
D R U G INTERACTIONS WITH WARFARIN: STUDIES WITH DICHLORALPHENAZONE, CHLORAL (2012) (0)
Environmental factors affecting monooxygenase activity of microsomal fractions of human liver biopsies (2007) (0)
Contents, Vol. 27, 1975 (1975) (0)
The mutational signature of alpha-hydroxytamoxifen at Hprt locus in Chinese hamster cells. (2002) (0)
Effects of nortriptyline on the activities of human and rat liver microsome bufuralol 1'-hydroxylase in vitro. (1989) (0)
A comparison of standard and sustained release clonidine with respect to plasma concentration and blood pressure changes. (1985) (0)
A non-enzymic procdure for the quantitative analysis of (3-methoxy-4-sulphoxyphenyl)ethylene glycol(MHPG sulphate) in human urine using stable isotope dilution and gas chromatography-mass spectrometry. (1977) (0)
Biphasic Michaelis-Menten kinetics for ethoxycoumarin and phenacetin metabolism by human and rat hepatic monooxygenases [proceedings]. (1979) (0)
Induction of Drug Oxidizing Enzymes (1970) (0)
Assaying for PhIP-induced mutations of p53 by RFLP/PCR (1996) (0)
Metabolism of some organotin compounds (with appendices on (i) liquid scintillation counting efficiencies and (ii) flourescence of compounds related to pyridoxol) (1966) (0)
Resolution andreconstitution oftwoforms of hepatic cytochrome P-450 fromrabbits (1979) (0)
Gerhard Zbinden MD FRCPath, Emeritus Professor of Toxicology at the University of Zurich (1994) (0)
738 – ORIGIN OF CONJUGATES OF 3-METHOXY-4-HYDROXYPHENYLETHYLENE GLYCOL (MHPG) IN HUMAN URINE (1978) (0)
Resolution and reconstitution of the forms of hepatic cytochrome P-450 from rabbits [proceedings]. (1979) (0)
Antibodies against rat cytochrome P-450d: comparison of the purified protein and a synthetic peptide as immunogens (1989) (0)
The activity of a sulphated polysaccharide, dextrin 2-sulphate , against primary syncytium and non-syncytium inducing isolates of HIV-1 in PBMN cells and in monocyte-derived macrophages (1995) (0)
The concentration effect relationships of clonidine in normotensive and hypertensive subjects (1976) (0)
The effect of MAO inhibitors on pre-systemic deamination of tyramine in the dog intestine (1984) (0)
Comparison of Serum Bilirubin Levels in Humans and Two Monogastric Animal Species After a Single Administration of Sulfisoxazole (1982) (0)
The effect of paraquat on the covalent binding of radio-labelled DOPA to liver and lung microsomal protein [proceedings]. (1979) (0)
Absorption and disposition of MeIQx in man: lessons for human dosimetry. (1991) (0)
Pharmacokinetics of [ 14 C ] FCE 22891 , a Penem Antibiotic , Following Oral Administration to Healthy Volunteers (0)
Substrate-metabolite profiles in the study of inter-individual differences in drug oxidation in man [proceedings]. (1979) (0)
Synthesis of 1‐(3‐trideuteromethoxy‐4‐hydroxyphenyl)‐[1,2,2‐2H3]‐ethyleneglycol ([2H6]MHPG) (1981) (0)
The specificity of inhibition of debrisoquine 4-hydroxylase activity by quinidine and quinine in the rat is the inverse of that in nans. (1989) (0)
The determination of terbutaline in human plasma by selected ion monitoring of the t-butyldiemthylsilyl ether (1980) (0)
A Comparison of the Ability of Various Compounds to Induce Cytochrome P-450 (1988) (0)
The correlation between in-vitro and in-vivo skin permeation models of a novel diclofenac formulation (2010) (0)
Dose-dependent enzyme induction. (1973) (0)
The Rational Interpretation of Species and Strain Differences for the Prediction of Risk to Man Introduction (1982) (0)

This paper list is powered by the following services:

What Schools Are Affiliated With Donald Selwyn Davies?

Donald Selwyn Davies is affiliated with the following schools:

Royal Postgraduate Medical School