D. Shannon Howell
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(Suggest an Edit or Addition)D. Shannon Howell's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Evidence for metalloproteinase and metalloproteinase inhibitor imbalance in human osteoarthritic cartilage. (1989) (613)
- Tensile properties of human knee joint cartilage: I. Influence of ionic conditions, weight bearing, and fibrillation on the tensile modulus (1986) (500)
- Mechanical Properties of Canine Articular Cartilage Are Significantly Altered Following Transection of the Anterior Cruciate Ligament (1994) (229)
- The pathogenesis of osteoarthritis. (1986) (213)
- Partition of calcium, phosphate, and protein in the fluid phase aspirated at calcifying sites in epiphyseal cartilage. (1968) (165)
- Collagenase and collagenolytic activity in human osteoarthritic cartilage. (1983) (163)
- Neutral proteases capable of proteoglycan digesting activity in osteoarthritic and normal human articular cartilage. (1984) (154)
- Metalloproteases of human articular cartilage that digest cartilage proteoglycan at neutral and acid pH. (1976) (147)
- Collagenolytic activity and collagen matrix breakdown of the articular cartilage in the Pond-Nuki dog model of osteoarthritis. (1983) (145)
- Cathepsin D activity in normal and osteoarthritic human cartilage. (1973) (130)
- Role of synovial membrane inflammation in cartilage matrix breakdown in the Pond-Nuki dog model of osteoarthritis. (1985) (124)
- Treatment of canine osteoarthritis with insulin-like growth factor-1 (IGF-1) and sodium pentosan polysulfate. (1993) (119)
- Biomechanical and biochemical properties of dog cartilage in experimentally induced osteoarthritis. (1984) (113)
- Tensile properties of human knee joint cartilage. II. Correlations between weight bearing and tissue pathology and the kinetics of swelling (1987) (108)
- Wild Type and Mutant p53 Differentially Regulate the Gene Expression of Human Collagenase-3 (hMMP-13)* (2000) (105)
- Joint cartilage degradation : basic and clinical aspects (1993) (103)
- Cartilage proteoglycan alterations in an experimentally induced model of rabbit osteoarthritis. (1979) (103)
- Neutral proteases and cathepsin D in human articular cartilage. (1974) (101)
- Pyridoxine deficiency affects biomechanical properties of chick tibial bone. (1996) (98)
- Demonstration of macromolecular inhibitors of calcification and nucleational factors in fluid from calcifying sites in cartilage. (1969) (97)
- American Rheumatism Association (1953) (97)
- Articular chondrocalcinosis. Microanalysis of pyrophosphate (PPi) in synovial fluid and plasma. (1973) (97)
- Comparative effect of ACTH, cortisone and DCA on renal function, electrolyte excretion and water exchange in normal dogs. (1953) (88)
- Mechanical behavior and biochemical composition of canine knee cartilage following periods of joint disuse and disuse with remobilization. (1997) (88)
- The action of cathepsin D in human articular cartilage on proteoglycans. (1973) (86)
- Altered mechanics and histomorphometry of canine tibial cartilage following joint immobilization. (2001) (83)
- Localization of collagenase in the growth plate of rachitic rats. (1985) (81)
- Comparison of phosphohydrolase activities from articular cartilage in calcium pyrophosphate deposition disease and primary osteoarthritis. (1981) (79)
- Pathogenesis of osteoarthritis. (1976) (77)
- Mechanisms of Fluid and Electrolyte Retention in Experimental Preparations in Dogs: II. With Thoracic Inferior Vena Cava Constriction (1953) (74)
- A microassay for the direct demonstration of collagenolytic activity in Graafian follicles of the rat. (1978) (73)
- Mechanisms of Fluid and Electrolyte Retention in Experimental Preparations in Dogs: III. Effect of Adrenalectomy and Subsequent Desoxycorticosterone Acetate Administration on Ascites Formation (1953) (72)
- Development of clinical criteria for osteoarthritis. (1987) (72)
- Vitamin D regulation of metalloproteinase activity in matrix vesicles. (1996) (70)
- Therapeutic treatment of canine osteoarthritis with glycosaminoglycan polysulfuric acid ester. (1989) (68)
- Evidence for a role of proteinpolysaccharides in regulation of mineral phase separation in calcifying cartilage. (1970) (65)
- Right‐Sided Congestive Heart Failure in Dogs Produced by Controlled Progressive Constriction of the Pulmonary Artery (1955) (63)
- Calcificaiton of growth plate cartilage with special reference to studies on micropuncture fluids. (1976) (62)
- Matrix vesicles produced by osteoblast-like cells in culture become significantly enriched in proteoglycan-degrading metalloproteinases after addition of β-Glycerophosphate and ascorbic acid (1994) (60)
- Association of collagenase and tissue inhibitor of metalloproteinases (TIMP) with hypertrophic cell enlargement in the growth plate. (1989) (58)
- Altered swelling behavior of femoral cartilage following joint immobilization in a canine model (2002) (58)
- THE COURSE OF RHEUMATOID ARTHRITIS DURING FOUR YEARS OF INDUCED HYPERADRENALISM (IHA) (1956) (56)
- Centrifugal and biochemical comparison of proteoglycan aggregates from articular cartilage in experimental joint disuse and joint instability (1994) (55)
- Matrix vesicles are enriched in metalloproteinases that degrade proteoglycans (1992) (55)
- Extrusion of pyrophosphate into extracellular media by osteoarthritic cartilage incubates. (1975) (55)
- Effects of vitamin D metabolites on healing of low phosphate, vitamin D-deficient induced rickets in rats. (1985) (55)
- Carriers of hepatitis virus in the blood and viral hepatitis in whole blood recipients. I. Studies on donors suspected as carriers of hepatitis virus and as sources of post-transfusion viral hepatitis. (1954) (50)
- The F-II agglutinating factors in serums of patients with non-rheumatic diseases. (1960) (49)
- Current Concepts of Calcification (1971) (49)
- NTP pyrophosphohydrolase in human chondrocalcinotic and osteoarthritic cartilage. II. Further studies on histologic and subcellular distribution. (1984) (48)
- Relationship of sodium retention to potassium excretion by the kidney during administration of desoxycorticosterone acetate to dogs. (1954) (48)
- Inhibition of insulin-like growth factor binding protein 5 proteolysis in articular cartilage and joint fluid results in enhanced concentrations of insulin-like growth factor 1 and is associated with improved osteoarthritis. (2002) (46)
- Neutral proteinases from articular chondrocytes in culture. 2. Metal-dependent latent neutral proteoglycanase, and inhibitory activity. (1981) (45)
- Relationship of extracellular matrix vesicles to calcification in normal and healing rachitic epiphyseal cartilage (1973) (45)
- Basic calcium phosphate crystals up-regulate metalloproteinases but down-regulate tissue inhibitor of metalloproteinase-1 and -2 in human fibroblasts. (2001) (43)
- Chemical and biomechanical characterization of hyperhomocysteinemic bone disease in an animal model (2003) (43)
- Effect of 1α,25-dihydroxyvitamin D3 and 24R,25-Dihydroxyvitamin D3 on metalloproteinase activity and cell maturation in growth plate cartilage in vivo (2001) (42)
- Lysozyme in preosseous cartilage VII. Evidence for physiological role of losozyme in normal endochondral calcification (1974) (41)
- Cartilage metalloproteases in disuse atrophy. (1995) (40)
- The effect of glycosaminoglycan polysulfuric acid ester on articular cartilage in experimental osteoarthritis: effects on morphological variables of disease severity. (1986) (40)
- Hypertrophic chondrocytes produce immunoreactive collagenase in vivo. (1989) (40)
- Further characterization of a neutral metalloprotease isolated from human articular cartilage. (1982) (40)
- Vitamin D Metabolites Regulate Matrix Vesicle Metalloproteinase Content in a Cell Maturation-Dependent Manner (1996) (38)
- Amelioration of lapine osteoarthritis by treatment with glycosaminoglycan-peptide association complex (Rumalon). (1991) (37)
- NTP pyrophosphohydrolase in human chondrocalcinotic and osteoarthritic cartilage. I. Some biochemical characteristics. (1984) (37)
- Effect of chronic pitressin administration on electrolyte excretion in normal dogs and in dogs with experimental ascites. (1954) (37)
- Altered structure-function relationships for articular cartilage in human osteoarthritis and an experimental canine model. (1993) (36)
- Hepatocyte growth factor and its actions in growth plate chondrocytes. (1996) (35)
- Sodium excretion in adrenalectomized dogs with chronic cardiac failure produced by pulmonary artery constriction. (1955) (35)
- Degradation of proteoglycans in human osteoarthritic cartilage. (1973) (34)
- Inhibition of calcium phosphate mineral growth by proteoglycan aggregate fractions in a synthetic lymph (2005) (33)
- PROGESTERONE BIOSYNTHESIS IN LUTEAL TISSUE: ROLE OF NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE AND NADP-LINKED DEHYDROGENASES. (1963) (33)
- Alterations in the composition of growth cartilage septa during calcification studied by microscopic x-ray elemental analysis. (1968) (32)
- Neutral proteinases from articular chondrocytes in culture. I. A latent collagenase that degrades human cartilage type II collagen. (1981) (32)
- Articular Cartilage Breakdown in a Lapine Model of Osteoarthritis: Action of Glycosaminoglycan Polysulfate Ester (GAGPS) on Proteoglycan Degrading Enzyme Activity, Hexuronate, and Cell Counts (1986) (31)
- Cartilage repair and conservation in osteoarthritis. A brief review of some experimental approaches to chondroprotection. (1993) (30)
- Quantitative polymerase chain reaction assay for aggrecan and link protein gene expression in cartilage. (1995) (29)
- Human rheumatoid arthritic cartilage and its neutral proteoglycan-degrading proteases. The effects of antirheumatic drugs. (1985) (29)
- Pyrophosphate release by osteoarthritis cartilage incubates. (1976) (28)
- Matrix vesicles contain metalloproteinases that degrade proteoglycans. (1992) (26)
- Regulation of rat interstitial collagenase gene expression in growth cartilage and chondrocytes by vitamin D3, interleukin‐1β, and okadaic acid (1996) (26)
- Degradative enzymes in osteoarthritic human articular cartilage (1975) (26)
- Metal-dependent neutral proteoglycanase activity from monolayer-cultured lapine articular chondrocytes. (1979) (26)
- The nature of phospholipids in normal and rachitic costochondral plates. (1965) (25)
- Ultramicro spectrophotometric determination of calcium in biologic fluids. (1966) (23)
- Treatment of Canine Osteoarthritis with Sodium Pentosan Polysulfate and Insulin‐Like Growth Factor‐1 (1994) (23)
- Identification of carbonic anhydrase in chick growth-plate cartilage. (1982) (23)
- Aspiration and Characterization of Predentin Fluid in Developing Rat Teeth by means of a Micropuncture and Micro-analytical Technique (1988) (23)
- Morphological abnormalities in vitamin B6 deficient tarsometatarsal chick cartilage. (1990) (23)
- Production of collagenase and tissue inhibitor of metalloproteinases (TIMP) by rat growth plates in culture. (1990) (23)
- Bone Mineral Density and Metabolism at an Early Stage of Menopause When Estrogen and Calcium Supplement Are Not Used and without the Interference of Major Confounding Variables (2005) (21)
- Possible role of extracellular matrix vesicles in initial calcification of healing rachitic cartilage. (1976) (21)
- Effects of Acute and Chronic Digoxin Administration in Dogs with Right‐Sided Congestive Heart Failure Produced by Pulmonary Artery Constriction (1955) (21)
- Changes in the sedimentation profile of proteoglycan aggregates in early experimental canine osteoarthritis. (1989) (20)
- Characterization of the metalloproteinase inhibitor produced by bovine articular chondrocyte cultures. (1983) (18)
- The effect of glycosaminoglycan polysulfuric acid ester on articular cartilage in experimental arthritis: effects on collagenolytic enzyme activity and cartilage swelling properties. (1987) (18)
- Accumulation of ascites during maintenance of adrenalectomized dogs with thoracic inferior vena cava constriction on a high sodium diet without hormone therapy. (1956) (18)
- Characterization of the proteoglycans recovered under nondissociative conditions from normal articular cartilage of rabbits and dogs. (1986) (17)
- A view on the pathogenesis of osteoarthritis. (1978) (17)
- Influence of griseofulvin upon acute gouty arthritis. (1962) (17)
- A mini review: proteoglycan aggregate profiles in the Pond-Nuki dog model of osteoarthritis and in canine disuse atrophy. (1992) (16)
- The comparative effects of phenylbutazone and G27202 (metabolite I) in patients with rheumatoid arthritis: an assessment of methods for antirheumatic drug evaluation. (1959) (16)
- Ultramicroanalysis of pH, $$P_{CO_2 } $$ and carbonic anhydrase activity at calcifying sites in cartilage (2005) (16)
- Superficial and deeper layers of dog normal articular cartilage. Role of hyaluronate and link protein in determining the sedimentation coefficients distribution of the nondissociatively extracted proteoglycans. (1988) (16)
- Distribution of acidic fibroblast growth factor, basic fibroblast growth factor, and transforming growth factor β1 in rat growth plate (1990) (15)
- Role of proteoglycans in calcification of cartilage. (1977) (15)
- Treatment of osteoarthritis with tiaprofenic acid: biochemical and histological protection against cartilage breakdown in the Pond-Nuki canine model. (1991) (14)
- Connective tissue integrity is lost in vitamin B-6-deficient chicks. (1995) (14)
- Enhancement of osteoinduction by vitamin D metabolites in rachitic host rats (1992) (14)
- Interleukin‐1α and β in Growth Plate Cartilage Are Regulated by Vitamin D Metabolites In Vivo (1997) (14)
- A photometric assay for protease digestion of the proteoglycan subunit. (1975) (13)
- The role of matrix vesicles in calcification (1978) (13)
- Prophylactic treatment of canine osteoarthritis with glycosaminoglycan polysulfuric acid ester. (1989) (13)
- Preliminary observations on local pH in gouty tophi and synovial fluid. (1965) (13)
- Further characterization of a nucleational agent in hypertrophic cell extraceilniar cartilage fluid (1978) (12)
- Articular cartilage calcification and matrix vesicles (2002) (12)
- EVIDENCE FOR A ROLE OF LYSOZYME IN ENDOCHRONDRAL CALCIFICATION DURING HEALING OF RICKETS (1975) (12)
- Renal hemodynamic function, electrolyte metabolism and water exchange in adrenalectomized-hypophysectomized dogs. (1954) (12)
- Osteoarthritis: definitions and criteria. (1990) (12)
- REGULATION OF EPIPHYSEAL CARTILAGE MATURATION (1975) (11)
- SULFUR METABOLISM IN CARTILAGE. A STUDY OF CALCIFYING REGIONS FOR MICROSCOPIC DISTRIBUTION OF SULFUR AND RELATIONSHIP TO STAINING BY SUDAN BLACK. (1964) (10)
- Effect of Hypophysectomy on Electrolyte Excretion in Dogs with Ascites Produced by Thoracic Inferior Vena Cava Constriction (1955) (10)
- Regulation of the rat interstitial collagenase promoter by IL‐1β, c‐Jun, and ras‐dependent signaling in growth plate chondrocytes (1997) (10)
- 'Gelatinase-like' activity from articular chondrocytes in monolayer culture. (1983) (10)
- A Cartilage Matrix Deficiency Experimentally Induced by Vitamin B6 Deficiency (1998) (10)
- New directions in therapy of osteoarthritis. (1987) (10)
- THE EFFECT OF PAPAIN ON MINERAL DEPOSITION IN THE HEALING OF RACHITIC EPIPHYSES. (1965) (9)
- Kinetics of Proteoglycans and Cells in Growth Plate of Normal, Diabetic, and Malnourished Rats (1990) (9)
- Proteoglycans nondissociatively extracted from different zones of canine normal articular cartilage: variations in the sedimentation profile of aggregates with degree of physiological stress. (1991) (9)
- EHDP‐induced rachitic syndrome in rats is not reversed by vitamin D metabolites (1988) (9)
- HISTOLOGIC OBSERVATIONS AND BIOCHEMICAL COMPOSITION OF RACHITIC CARTILAGE WITH SPECIAL REFERENCE TO MUCOPOLYSACCHARIDES. (1965) (8)
- Preliminary observations on phosphatases in articular cartilages. (1976) (8)
- Spontaneous Mineral Deposition in Sponge Biopsy Connective Tissue.∗ (1961) (7)
- Diuresis during maintenance of adrenalectomized dogs with ascites on cortisone. (1953) (7)
- Direct measurement of cartilage collagenolytic activity in human osteoarthritis (1981) (7)
- Determination of total and unbound calcium in nanoliter samples of cartilage fluid and serum. (1978) (7)
- Serologic methods employing F-II reactant as an aid to diagnosis of rheumatoid arthritis. (1961) (7)
- Perturbations in factors that modulate osteoblast functions in vitamin B6 deficiency. (2000) (7)
- Possible role of lysozyme in degradation of osteoarthritic cartilage. (1974) (6)
- Aberrancy in clinical hallmarks of gouty arthritis: brief clinical report. (1965) (6)
- EVIDENCE FOR AN ORGANIC NUCLEATIONAL AGENT OF CALCIUM PHOSPHATE MINERAL FORMS IN ENDOCHRONDAL PLATES (1975) (5)
- Mechanisms of Mineralization (Normal) Group Report (1982) (5)
- Future therapeutic trends in osteoarthritis. (1988) (5)
- X-Ray Ultramicroanalysis of Sulfur in Calf Costochondral Plates. (1963) (5)
- Morphological changes and swelling properties of osteoarthritic dog cartilage (1981) (5)
- Loss of decorin from the surface zone of articular cartilage in a chick model of osteoarthritis. (1997) (5)
- Proteolytic enzymes in human cartilage: the pathogenesis of osteoarthritis. (1976) (5)
- CONCEPTS OF CALCIFICATION. (1963) (5)
- Experimental mitral stenosis and ascites formation. (1957) (5)
- Primary septic bursitis. (1963) (4)
- Neutral proteinases from articular chondrocytes in culture that degrade synthetic substrates and cartilage macromolecules (1981) (4)
- Extrusion of pyrophosphate into extracellular media by osteoarthritic cartilage incubates (1975) (4)
- Review article. Current concepts of calcification. (1971) (4)
- Evaluation of drug responses in the patient severely afflicted with rheumatoid arthritis. (1969) (4)
- The possible function of lysozyme in cartilage metabolism. (1975) (3)
- A micropuncture study of growth cartilage in phosphonate (EHDP) induced rickets (2006) (3)
- Evidence for a Role of Lysozyme in Endochondral Calcification (1975) (3)
- Neutral metalloproteases and their inhibitors from cultured articular chondrocytes (1981) (3)
- Circulatory manifestations of obstruction of the superior vena cava in a patient with portal hypertension. (1950) (2)
- A comprehensive regimen for osteoarthritis. (1971) (2)
- Altered mechanics of tibial cartilage following joint immobilization in a canine model (1999) (2)
- Structural Changes of Sulfated Proteoglycans of the Growth Cartilage of Rats during Endochondral Calcification (1979) (2)
- The research arena of this symposium and an outlook for future treatment of osteoarthritis. (1989) (2)
- Crystal and Joint Disease (review) (2015) (1)
- Application of new techniques to separation of proteoglycan aggregates from normal and destabilized rabbit articular cartilages. (1984) (1)
- Pemberton lecture. Degradative enzymes in osteoarthritic human articular cartilage. (1975) (1)
- Effects of pentosan polysulphate and growth factors on cartilage integrity in animal models of osteoarthritis (1996) (1)
- Characterization of rabbit articular cartilage by rate-zonal centrifugation (1981) (1)
- Some Analytical Ultramicro-Techniques (1974) (1)
- Treatment of Osteoarthritis with Tiaprofenic Acid and Indomethacin (1991) (1)
- Nucleoside Triphosphate (NTP) Pyrophosphohydrolase in Chondrocalcinotic and Osteoarthritic Cartilages (1985) (1)
- Growth plate cartilage contains cytokines implicated im matrix remodelling (1992) (1)
- The course of systemic lupus erythematosus in a subtropical medical center. (1969) (1)
- Evidence for altered proteinpolysaccharide complexes (PPC) in fresh osteoarthritic cartilage in human hips (2005) (1)
- Interleukin-1alpha and beta in growth plate cartilage are regulated by vitamin D metabolites in vivo. (1997) (1)
- A non-coronary syndrome cause of elevated troponin. (2011) (1)
- IADR 1993-1994 Committees (1993) (0)
- Treatment of Osteoarthritis with Tiaprofenic Acid (0)
- Ascorbic acid stimulates the resorption of canine articular cartilage induced by a factor derived from activated rabbit macrophages (2004) (0)
- osteoarthritis . experimentally induced properties of dog cartilage in Biomechanical and biochemical and (0)
- NEUTRAL AND ACID METALLOPROTEINASES IN HUMAN ARTICULAR CARTILAGE WHICH DEGRADE PROTEOGLYCAN (1976) (0)
- Calcification mechanisms. (1976) (0)
- 15. Enzymes in Degenerative Joint Disease and Antienzyme Therapy (1978) (0)
- 304 AMELIORATION OF LAPINE OSTEOARTHRITIS BY ASSOCIATION COMPLEX ( RUMALON ) TREATMENT WITH GLYCOSAMINOGLYCAN-PEPTIDE (2005) (0)
- Altered Swelling-Induced Strain Fields in Articular Cartilage Following Periods of Immobilization (1997) (0)
- Bone Metabolic Imbalance Occurs at an Early Stage of Natural Menopause (2005) (0)
- In Memoriam: John H. Talbott, MD (1902–1990) (1990) (0)
- Biochemical aspects of osteoarthritis. (1990) (0)
- A comparative ultrastructural study of the mineralization defect observed in low-phosphate vitamin D deficiency rickets and EHDP-induced rickets in rats☆ (1985) (0)
- Biology of Cartilage Cells. R. A. Stockwell. Cambridge, Cambridge University Press, 1979. 329 pages; illustrated (1980) (0)
- Loss of integrity of connective tissue in vitamin B-6 deficient chicks (1994) (0)
- $TEOARTHRITIS and CARTILAGE ;merit of canine osteoarthritis with insulin-like growth factor-1 (IGF-1) and sodium pentosan polysulfate (1993) (0)
- Methyl salicylate poisoning; report of a case. (1949) (0)
- Nucleating and inhibitor properties of fluid aspirated from calcifying sites by micropuncture (2005) (0)
- Conference on articular cartilage—bio‐mechanics unit of the imperial college of science and technology. Edited by G. E. Kempson, A. Maroudas, and B. Weightman. London, England, Annals of the Rheumatic Diseases, Volume 34, Supplement 2, December 1975 (1976) (0)
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