David Seymour Latchman

David Seymour Latchman's AcademicInfluence.com Rankings

Biology

#5459

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#7945

Historical Rank

Molecular Biology

#487

World Rank

#498

Historical Rank

Biochemistry

#647

World Rank

#744

Historical Rank

biology Degrees

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Biology

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David Seymour Latchman's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1 (2004) (3255)
Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction. (1993) (1111)
Transcription factors: an overview. (1993) (777)
PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death (2009) (614)
Biochemistry (4th edn) (1995) (608)
Voltage-Gated Sodium Channel Expression and Potentiation of Human Breast Cancer Metastasis (2005) (422)
Heat shock proteins and cardiac protection. (2001) (381)
PINK1 protein in normal human brain and Parkinson's disease. (2006) (333)
PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons (2008) (311)
Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury. (2006) (285)
Eukaryotic transcription factors. (1990) (270)
Dysregulation of histone acetylation in the APP/PS1 mouse model of Alzheimer's disease. (2009) (254)
Urocortin Protects against Ischemic and Reperfusion Injury via a MAPK-dependent Pathway* (2000) (242)
STAT-1 Interacts with p53 to Enhance DNA Damage-induced Apoptosis* (2004) (235)
Ischemia-induced STAT-1 Expression and Activation Play a Critical Role in Cardiomyocyte Apoptosis* (2000) (227)
Protection of Neuronal Cells from Apoptosis by Hsp27 Delivered with a Herpes Simplex Virus-based Vector* (1999) (223)
Activity of herpes simplex virus type 1 latency-associated transcript (LAT) promoter in neuron-derived cells: evidence for neuron specificity and for a large LAT transcript (1990) (207)
The protective role of heat stress in the ischaemic and reperfused rabbit myocardium. (1992) (196)
Insulin administered at reoxygenation exerts a cardioprotective effect in myocytes by a possible anti-apoptotic mechanism. (2000) (188)
Induction of Apoptosis and Fas Receptor/Fas Ligand Expression by Ischemia/Reperfusion in Cardiac Myocytes Requires Serine 727 of the STAT-1 Transcription Factor but Not Tyrosine 701* (2001) (186)
Opposing actions of STAT-1 and STAT-3 on the Bcl-2 and Bcl-x promoters (2000) (183)
Effect of aging on the ability of preconditioning to protect rat hearts from ischemia-reperfusion injury. (2001) (183)
The Transcriptional Co-activators CREB-binding Protein (CBP) and p300 Play a Critical Role in Cardiac Hypertrophy That Is Dependent on Their Histone Acetyltransferase Activity* (2003) (182)
Different Signaling Pathways Induce Apoptosis in Endothelial Cells and Cardiac Myocytes During Ischemia/Reperfusion Injury (2002) (177)
A heterozygous effect for PINK1 mutations in Parkinson's disease? (2006) (175)
Urocortin protects the heart from reperfusion injury via upregulation of p42/p44 MAPK signaling pathway. (2002) (174)
Heat shock protects neuronal cells from programmed cell death by apoptosis (1993) (173)
Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress (2006) (165)
p53 Suppresses the Activation of the Bcl-2 Promoter by the Brn-3a POU Family Transcription Factor* (1999) (163)
STAT‐1: a novel regulator of apoptosis (2003) (160)
The Neuroprotective Effects of Heat Shock Protein 27 Overexpression in Transgenic Animals against Kainate-induced Seizures and Hippocampal Cell Death* (2003) (156)
Differential cytoprotection against heat stress or hypoxia following expression of specific stress protein genes in myogenic cells. (1995) (155)
Heat shock proteins delivered with a virus vector can protect cardiac cells against apoptosis as well as against thermal or hypoxic stress. (1999) (150)
Targeted disruption of the protein kinase C epsilon gene abolishes the infarct size reduction that follows ischaemic preconditioning of isolated buffer-perfused mouse hearts. (2002) (149)
Gene Regulation: A Eukaryotic Perspective (1990) (143)
Minocycline inhibits caspase activation and reactivation, increases the ratio of XIAP to smac/DIABLO, and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO. (2004) (141)
Binding of antiphospholipid antibodies to discontinuous epitopes on domain I of human beta(2)-glycoprotein I: mutation studies including residues R39 to R43. (2007) (140)
Role of the JAK-STAT pathway in myocardial injury. (2007) (140)
Transcription-factor mutations and disease. (1996) (139)
Bimoclomol, a heat shock protein co-inducer, acts by the prolonged activation of heat shock factor-1. (2003) (138)
Bcl-2 Transcription from the Proximal P2 Promoter Is Activated in Neuronal Cells by the Brn-3a POU Family Transcription Factor* (1998) (135)
Urocortin-II and urocortin-III are cardioprotective against ischemia reperfusion injury: an essential endogenous cardioprotective role for corticotropin releasing factor receptor type 2 in the murine heart. (2004) (135)
Deletion of the Virion Host Shutoff Protein (vhs) from Herpes Simplex Virus (HSV) Relieves the Viral Block to Dendritic Cell Activation: Potential of vhs− HSV Vectors for Dendritic Cell-Mediated Immunotherapy (2003) (134)
Stress proteins and myocardial protection. (1992) (132)
HSP27 but not HSP70 has a potent protective effect against α‐synuclein‐induced cell death in mammalian neuronal cells (2004) (132)
Myocardial protection after whole body heat stress in the rabbit is dependent on metabolic substrate and is related to the amount of the inducible 70-kD heat stress protein. (1994) (132)
Activation of a Qa/Tla class I major histocompatibility antigen gene is a general feature of oncogenesis in the mouse (1983) (132)
Epigallocatechin‐3‐gallate inhibits STAT‐1 activation and protects cardiac myocytes from ischemia/reperfusion‐ induced apoptosis (2004) (129)
Disulfide-Dependent Multimeric Assembly of Resistin Family Hormones (128)
IL-6 induces PI 3-kinase and nitric oxide-dependent protection and preserves mitochondrial function in cardiomyocytes. (2006) (128)
Over-expression of heat shock protein 70 protects neuronal cells against both thermal and ischaemic stress but with different efficiencies (1996) (127)
Multiple Immediate-Early Gene-Deficient Herpes Simplex Virus Vectors Allowing Efficient Gene Delivery to Neurons in Culture and Widespread Gene Delivery to the Central Nervous System In Vivo (2001) (126)
Signal Transducer and Activator of Transcription-1 and Heat Shock Factor-1 Interact and Activate the Transcription of the Hsp-70 and Hsp-90β Gene Promoters* (1999) (123)
Transcription factors : a practical approach (1993) (123)
Development and Optimization of Herpes Simplex Virus Vectors for Multiple Long-Term Gene Delivery to the Peripheral Nervous System (2000) (123)
Increased heat shock protein 90 (hsp90) expression leads to increased apoptosis in the monoblastoid cell line U937 following induction with TNF-alpha and cycloheximide: a possible role in immunopathology. (1996) (122)
Heat Shock Proteins hsp90 and hsp70 Protect Neuronal Cells from Thermal Stress but Not from Programmed Cell Death (1994) (120)
Activation of protein kinase B/Akt by urocortin is essential for its ability to protect cardiac cells against hypoxia/reoxygenation-induced cell death. (2002) (117)
CRH-like peptides protect cardiac myocytes from lethal ischaemic injury (1999) (115)
Utilization of the VH4-21 gene segment by anti-DNA antibodies from patients with systemic lupus erythematosus. (1993) (115)
Transcripts regulated during normal embryonic development and oncogenic transformation share a repetitive element (1983) (115)
Stable high level expression of a transfected human HSP70 gene protects a heart-derived muscle cell line against thermal stress. (1994) (114)
Raised levels of interleukin 6 in systemic lupus erythematosus correlate with anaemia (2005) (114)
POU family transcription factors in the nervous system (1999) (113)
The Transcriptional Co-activators CBP and p300 Are Activated via Phenylephrine through the p42/p44 MAPK Cascade* (2002) (111)
A novel POU family transcription factor is closely related to Brn-3 but has a distinct expression pattern in neuronal cells. (1992) (109)
Antibodies to apolipoprotein A-I, high-density lipoprotein, and C-reactive protein are associated with disease activity in patients with systemic lupus erythematosus. (2010) (108)
Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression (2008) (106)
The octamer-binding protein Oct-2 represses HSV immediate-early genes in cell lines derived from latently infectable sensory neurons (1991) (106)
Cell Cycle Arrest of Proliferating Neuronal Cells by Serum Deprivation Can Result in Either Apoptosis or Differentiation (1993) (106)
Specific induction of the 70-kD heat stress proteins by the tyrosine kinase inhibitor herbimycin-A protects rat neonatal cardiomyocytes. A new pharmacological route to stress protein expression? (1996) (104)
A cellular protein related to heat-shock protein 90 accumulates during herpes simplex virus infection and is overexpressed in transformed cells. (1988) (103)
Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade. (1999) (103)
Hsp27 and Hsp70 administered in combination have a potent protective effect against FALS-associated SOD1-mutant-induced cell death in mammalian neuronal cells. (2005) (99)
Cardiotrophin-1 (CT-1) can protect the adult heart from injury when added both prior to ischaemia and at reperfusion. (2002) (99)
Do heat shock proteins have a role in breast cancer? (1996) (98)
In vivo myocardial gene transfer: Optimization, evaluation and direct comparison of gene transfer vectors (2001) (98)
Octamer motif mediates transcriptional repression of HSV immediate-early genes and octamer-containing cellular promoters in neuronal cells (1990) (93)
Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation. (2007) (91)
Antibodies to heat-shock protein 27 are associated with improved survival in patients with breast cancer. (1998) (90)
Nerve Growth Factor Up-regulates the Transcriptional Activity of CBP through Activation of the p42/p44MAPK Cascade* (1998) (90)
Genetic, structural and functional properties of an IgG DNA‐binding monoclonal antibody from a lupus patient with nephritis (1998) (87)
HSP27 and cell survival in neurones (2005) (87)
PIAS-1 Is a Checkpoint Regulator Which Affects Exit from G1 and G2 by Sumoylation of p73 (2004) (86)
Parkin is recruited into aggresomes in a stress-specific manner: over-expression of parkin reduces aggresome formation but can be dissociated from parkin's effect on neuronal survival. (2003) (84)
Stressful preconditioning and HSP70 overexpression attenuate proteotoxicity of cellular ATP depletion. (2002) (82)
Distinct signalling pathways mediate the cAMP response element (CRE)-dependent activation of the calcitonin gene-related peptide gene promoter by cAMP and nerve growth factor. (2000) (81)
STAT3 modulates the DNA damage response pathway (2010) (81)
Urocortin promotes hemodynamic and bioenergetic recovery and improves cell survival in the isolated rat heart exposed to ischemia/reperfusion. (2002) (81)
Interleukin 6 activates heat-shock protein 90 beta gene expression. (1997) (80)
Molecular basis of Parkinson's disease. (2009) (80)
Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia/reperfusion‐induced injury (2009) (80)
Clinical implications of apoptosis in ischemic myocardium. (2006) (77)
Differential heat shock protein overexpression and its clinical relevance in systemic lupus erythematosus. (1993) (76)
Regulation of Neurite Outgrowth and SNAP-25 Gene Expression by the Brn-3a Transcription Factor (*) (1995) (76)
STAT1 interacts directly with cyclin D1/Cdk4 and mediates cell cycle arrest (2010) (74)
Effects of Polyclonal IgG Derived from Patients with Different Clinical Types of the Antiphospholipid Syndrome on Monocyte Signaling Pathways (2010) (73)
BAG-1: a multi-functional pro-survival molecule. (2005) (73)
The cyclic AMP response element in the Bcl-2 promoter confers inducibility by hypoxia in neuronal cells. (2001) (73)
Activation of CDK4 Gene Expression in Human Breast Cancer Cells by the Brn-3b POU Family Transcription Factor (2004) (72)
The Brn-3b POU family transcription factor represses expression of the BRCA-1 anti-oncogene in breast cancer cells (1999) (72)
Herpes Simplex Virus Latency-Associated Transcript Encodes a Protein Which Greatly Enhances Virus Growth, Can Compensate for Deficiencies in Immediate-Early Gene Expression, and Is Likely To Function during Reactivation from Virus Latency (1999) (71)
Transcriptional Gene Regulation in Eukaryotes (2001) (71)
POU Transcription Factors Brn-3a and Brn-3b Interact with the Estrogen Receptor and Differentially Regulate Transcriptional Activity via an Estrogen Response Element (1998) (70)
Transcriptional Modulation of Heat-Shock Protein Gene Expression (2010) (70)
Autoantibodies to the 90kDa heat shock protein and poor survival in breast cancer patients. (1998) (70)
A minimal Bcl-x promoter is activated by Brn-3a and repressed by p53. (2001) (69)
The Brn-3a transcription factor induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins (1997) (69)
Gene delivery to the central and peripheral nervous systems of mice using HSV1 ICP34.5 deletion mutant vectors. (1996) (69)
Focal cerebral ischaemia increases the levels of several classes of heat shock proteins and their corresponding mRNAs. (1996) (69)
Detection of autoantibodies to the 90 kDa heat shock protein in systemic lupus erythematosus and other autoimmune diseases. (1994) (68)
The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of a target promoter are dependent on differences in the POU domain (1994) (68)
Free radical scavenging inhibits STAT phosphorylation following in vivo ischemia/reperfusion injury (2006) (67)
Activation of the α-Internexin Promoter by the Brn-3a Transcription Factor Is Dependent on the N-terminal Region of the Protein (*) (1995) (66)
Heat shock protein 27 shows a distinctive widespread spatial and temporal pattern of induction in CNS glial and neuronal cells compared to heat shock protein 70 and caspase 3 following kainate administration. (2001) (65)
Urocortin prevents mitochondrial permeability transition in response to reperfusion injury indirectly by reducing oxidative stress. (2007) (65)
CBP associates with the p42/p44 MAPK enzymes and is phosphorylated following NGF treatment. (1999) (65)
Alternative splicing of the Oct-2 transcription factor RNA is differentially regulated in neuronal cells and B cells and results in protein isoforms with opposite effects on the activity of octamer/TAATGARAT-containing promoters. (1992) (63)
Differential stress protein mRNA expression during early ischaemic preconditioning in the rabbit heart and its relationship to adenosine receptor function. (1995) (63)
Neuroprotective effects of HSP70 overexpression after cerebral ischaemia—An MRI study (2005) (62)
Surface expression of heat shock protein 90 by blood mononuclear cells from patients with systemic lupus erythematosus. (1992) (62)
BAG-1 Proteins Protect Cardiac Myocytes from Simulated Ischemia/Reperfusion-induced Apoptosis via an Alternate Mechanism of Cell Survival Independent of the Proteasome* (2004) (62)
Heat shock protein 27 delivered via a herpes simplex virus vector can protect neurons of the hippocampus against kainic-acid-induced cell loss. (2003) (61)
Coordinate Induction of the Three Neurofilament Genes by the Brn-3a Transcription Factor* (1997) (61)
Elevated levels of the 90 kDa heat shock protein (hsp90) in SLE correlate with levels of IL-6 and autoantibodies to hsp90. (2001) (60)
Epigallocatechin-3-gallate inhibits STAT-1 activation and protects cardiac myocytes from ischemia/reperfusion-induced apoptosis. (2004) (60)
Transcription factors: bound to activate or repress. (2001) (60)
β-Subunits of voltage-gated sodium channels in human prostate cancer: quantitative in vitro and in vivo analyses of mRNA expression (2008) (60)
STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage (2005) (59)
The BRN-3A Transcription Factor Protects Sensory but Not Sympathetic Neurons from Programmed Cell Death/Apoptosis* (2001) (59)
Gene delivery and gene therapy with herpes simplex virus-based vectors. (2001) (59)
Brn-3a Activates the Expression of Bcl-xL and Promotes Neuronal Survival in Vivo as Well as in Vitro (2001) (58)
Heat shock protein 70 or heat shock protein 27 overexpressed in human endothelial cells during posthypoxic reoxygenation can protect from delayed apoptosis (2003) (58)
A γ34.5 mutant of herpes simplex 1 causes severe inflammation in the brain (1998) (57)
Protective effect of heat shock proteins in the nervous system. (2004) (57)
Proof-of-concept study demonstrating the pathogenicity of affinity-purified IgG antibodies directed to domain I of β2-glycoprotein I in a mouse model of anti-phospholipid antibody-induced thrombosis (2014) (57)
The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21CIP1/Waf1 (2002) (56)
The selective PPARgamma antagonist GW9662 reverses the protection of LPS in a model of renal ischemia-reperfusion. (2005) (56)
Neuroprotective Effects of Virally Delivered HSPs in Experimental Stroke (2006) (55)
Human sperm–egg binding is inhibited by peptides corresponding to core region of an acrosomal serine protease inhibitor (1993) (55)
Effect of neutralizing antibodies to IL-10 and C5 on the renal damage caused by a pathogenic human anti-dsDNA antibody. (2004) (54)
The Oct-2 transcription factor. (1996) (53)
A Protein Encoded by the Herpes Simplex Virus (HSV) Type 1 2-Kilobase Latency-Associated Transcript Is Phosphorylated, Localized to the Nucleus, and Overcomes the Repression of Expression from Exogenous Promoters When Inserted into the Quiescent HSV Genome (2002) (52)
Regulation of expression of the neuronal POU protein Oct-2 by nerve growth factor. (1992) (52)
The 90-kDa heat shock protein protects mammalian cells from thermal stress but not from viral infection. (1991) (52)
How do antiphospholipid antibodies bind β2-glycoprotein I? (2003) (52)
STAT3 deletion sensitizes cells to oxidative stress (2009) (51)
The degree of protection provided to neuronal cells by a pre-conditioning stress correlates with the amount of heat shock protein 70 it induces and not with the similarity of the subsequent stress (1995) (51)
Gene delivery to the heart in vivo and to cardiac myocytes and vascular smooth muscle cells in vitro using herpes virus vectors. (1996) (51)
Intracellular redistribution of neuropeptides and secretory proteins during differentiation of neuronal cell lines (1992) (51)
Serological and genetic characterization of a human monoclonal immunoglobulin G anti-DNA idiotype. (1994) (50)
Enhanced IL-17 signalling following myocardial ischaemia/reperfusion injury (2013) (49)
The C‐terminal activation domain of the STAT‐1 transcription enhances ischemia/reperfusion‐induced apoptosis in cardiac myocytes (2002) (49)
Urocortin protects cardiac myocytes from ischemia/reperfusion injury by attenuating calcium insensitive phospholipase A2 gene expression (2003) (49)
Genetic manipulation of the nervous system (1995) (49)
Apoptosis in peripheral lymphocytes in systemic lupus erythematosus: a review. (1997) (49)
Trigeminal ganglion neurons are protected by the heat shock proteins hsp70 and hsp90 from thermal stress but not from programmed cell death following nerve growth factor withdrawal. (1996) (48)
CT-1 mediated cardioprotection against ischaemic re-oxygenation injury is mediated by PI3 kinase, Akt and MEK1/2 pathways. (2001) (48)
Whole body heat stress fails to limit infarct size in the reperfused rabbit heart. (1992) (47)
Cardiotrophin-1 and urocortin cause protection by the same pathway and hypertrophy via distinct pathways in cardiac myocytes. (2002) (46)
Repression of a herpes simplex virus immediate-early promoter by the Oct-2 transcription factor is dependent on an inhibitory region at the N terminus of the protein (1994) (46)
Hypertrophic effects of urocortin homologous peptides are mediated via activation of the Akt pathway. (2005) (46)
The production, binding characteristics and sequence analysis of four human IgG monoclonal antiphospholipid antibodies. (1997) (45)
Overexpression of Heat Shock Protein 27 Reduces Cortical Damage after Cerebral Ischemia (2010) (45)
Elevated levels of the 90 kd heat shock protein in a proportion of SLE patients with active disease. (1989) (44)
ERK and the F-box Protein βTRCP Target STAT1 for Degradation* (2008) (44)
HSV infection induces increased transcription of Alu repeated sequences by RNA polymerase III (1989) (44)
The role of the 90-kDa heat shock protein in cell cycle control and differentiation of the monoblastoid cell line U937. (1996) (44)
Nerve growth factor up-regulates the transcriptional activity of CBP through activation of the p42/p44(MAPK) cascade. (1998) (44)
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression (2006) (44)
Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter. (2005) (44)
The herpes simplex virus immediate-early protein ICP27 stimulates the transcription of cellular Alu repeated sequences by increasing the activity of transcription factor TFIIIC. (1992) (43)
Cardiotrophin-1: a novel cytokine and its effects in the heart and other tissues. (2000) (43)
Activation of the cellular transcription factor AP-1 in herpes simplex virus infected cells is dependent on the viral immediate-early protein ICPO. (1991) (43)
Signal transducer and activator of transcription-1 and heat shock factor-1 interact and activate the transcription of the Hsp-70 and Hsp-90beta gene promoters. (1999) (43)
The Oct-2 transcription factor represses tyrosine hydroxylase expression via a heptamer TAATGARAT-like motif in the gene promoter. (1994) (42)
Synphilin-1 and parkin show overlapping expression patterns in human brain and form aggresomes in response to proteasomal inhibition (2005) (42)
A systematic analysis of sequences of human antiphospholipid and anti-beta2-glycoprotein I antibodies: the importance of somatic mutations and certain sequence motifs. (2003) (41)
Autoantibodies to 90 kD heat-shock protein in sera of breast cancer patients (1995) (41)
A novel expression system of domain I of human beta2 glycoprotein I in Escherichia coli (2006) (41)
The heat shock proteins and plastic surgery. (2007) (41)
The B-cell and neuronal forms of the octamer-binding protein Oct-2 differ in DNA-binding specificity and functional activity (1991) (41)
The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC. (1992) (40)
Bcl-2 and Fas, molecules which influence apoptosis. A possible role in systemic lupus erythematosus? (1994) (40)
Characterisation of a novel NR4A2 mutation in Parkinson's disease brain (2009) (40)
The HPV-activating cellular transcription factor Brn-3a is overexpressed in CIN3 cervical lesions. (1998) (40)
The Brn-3a transcription factor. (1998) (39)
Nurr1 transcriptionally regulates the expression of &agr;-synuclein (2008) (39)
The DNA target site for the Brn-3 POU family transcription factors can confer responsiveness to cyclic AMP and removal of serum in neuronal cells. (1994) (39)
New targets of urocortin-mediated cardioprotection (2010) (38)
Transcriptional induction of the ubiquitin gene during herpes simplex virus infection is dependent upon the viral immediate-early protein ICP4. (1987) (38)
The N-terminal domain unique to the long form of the Brn-3a transcription factor is essential to protect neuronal cells from apoptosis and for the activation of Bbcl-2 gene expression. (1998) (37)
The Transcriptional Coactivator p300 Plays a Critical Role in the Hypertrophic and Protective Pathways Induced by Phenylephrine in Cardiac Cells but Is Specific to the Hypertrophic Effect of Urocortin (2005) (37)
Incidence of anti Hsp 90 and 70 antibodies in children with SLE, juvenile dermatomyositis and juvenile chronic arthritis. (1996) (37)
A Single Amino Acid Change Converts an Inhibitory Transcription Factor into an Activator (*) (1996) (37)
The closely related POU family transcription factors Brn-3a and Brn-3b are expressed in distinct cell types in the testis. (2001) (36)
Heat shock proteins: protective effect and potential therapeutic use (review). (1998) (36)
The octamer-binding proteins Oct-1 and Oct-2 repress the HIV long terminal repeat promoter and its transactivation by Tat. (1997) (36)
Urocortin protects against ischemic injury via a MAPK-dependent pathway. (2001) (35)
Correction: PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons (2008) (35)
Inhibitory transcription factors. (1996) (35)
The octamer binding site in the HPV16 regulatory region produces opposite effects on gene expression in cervical and non-cervical cells. (1993) (35)
Differential regulation of genes encoding synaptic proteins by members of the Brn-3 subfamily of POU transcription factors. (1996) (35)
Induction of parkin expression in the presence of oxidative stress (2006) (35)
Attenuation by heat stress of a submaximal calcium paradox in the rabbit heart. (1993) (35)
Selective internalization of sodium channels in rat dorsal root ganglion neurons infected with herpes simplex virus-1 (2002) (34)
Arginine Residues Are Important in Determining the Binding of Human Monoclonal Antiphospholipid Antibodies to Clinically Relevant Antigens1 (2006) (34)
Herpes simplex virus and risk of Alzheimer's disease (1997) (34)
Isolation of cDNA clones derived from a cellular gene transcriptionally induced by herpes simplex virus. (1986) (34)
The effects of Brn-3a on neuronal differentiation and apoptosis are differentially modulated by EWS and its oncogenic derivative EWS/Fli-1 (2004) (33)
Warm blood cardioplegic arrest induces mitochondrial-mediated cardiomyocyte apoptosis associated with increased urocortin expression in viable cells. (2004) (33)
A Minimal CGRP Gene Promoter is Inducible by Nerve Growth Factor in Adult Rat Dorsal Root Ganglion Neurons But Not in PC12 Phaeochromocytoma Cells (1995) (33)
The octamer binding protein Oct-2 inhibits transactivation of the herpes simplex virus immediate-early genes by the virion protein Vmw65. (1993) (33)
The cardioprotective effect of urocortin during ischaemia/reperfusion involves the prevention of mitochondrial damage. (2004) (33)
Cardiotrophin‐1 (CT‐1): a novel hypertrophic and cardioprotective agent (1999) (33)
The class I major histocompatibility antigen gene activated in a line of SV40-transformed mouse cells is H–2Dd, not Qa/Tla (1985) (33)
Expression and splicing of the latency-associated transcripts of herpes simplex virus type 1 in neuronal and non-neuronal cell lines. (1995) (33)
SAG attenuates apoptotic cell death caused by simulated ischaemia/reoxygenation in rat cardiomyocytes. (2003) (33)
Oct-1 [corrected] and Oct-2 DNA-binding site specificity is regulated in vitro by different kinases. (1996) (33)
Identification and characterization of the promoter region of the Nav1.7 voltage-gated sodium channel gene (SCN9A) (2008) (32)
Molecules in focus: Urocortin (2002) (32)
Elevated levels of the 90 kD heat shock protein in patients with systemic lupus erythematosus are dependent upon enhanced transcription of the hsp90 beta gene. (1993) (32)
PINK 1 protein in normal human brain and Parkinson ’ s disease (2006) (32)
Signal transducer and activator of transcription-1 localizes to the mitochondria and modulates mitophagy (2013) (31)
A common pathway mediates retinoic acid and PMA-dependent programmed cell death (apoptosis) of neuronal cells (1994) (31)
Nerve growth factor induces expression of immediate-early genes NGFI-A (Egr-1) and NGFI-B (nur 77) in adult rat dorsal root ganglion neurons. (1994) (31)
Differential Regulation of the Two Neuronal Nitric-oxide Synthase Gene Promoters by the Oct-2 Transcription Factor* (1996) (31)
Stress proteins--an endogenous route to myocardial protection: fact or fiction? (1993) (31)
The Brn-3b POU family transcription factor regulates the cellular growth, proliferation, and anchorage dependence of MCF7 human breast cancer cells (2001) (31)
Elevation of IL-6 in transgenic mice results in increased levels of the 90 kDa heat shock protein (hsp90) and the production of anti-hsp90 antibodies. (1998) (31)
Regulated transcription of herpes simplex virus immediate-early genes in neuroblastoma cells. (1989) (30)
A repeated proline-rich sequence in Sm B/B' and N is a dominant epitope recognized by human and murine autoantibodies. (1990) (30)
Herpes infection and AIDS (1987) (29)
Equine Herpesvirus 1 Gene 12 Can Substitute for vmw65 in the Growth of Herpes Simplex Virus (HSV) Type 1, Allowing the Generation of Optimized Cell Lines for the Propagation of HSV Vectors with Multiple Immediate-Early Gene Defects (1999) (29)
The occurrence, nature and distribution of flares in a cohort of patients with systemic lupus erythematosus: a rheumatological view. (1995) (28)
The C-terminal activation domain of the STAT-1 transcription factor is necessary and sufficient for stress-induced apoptosis (2002) (28)
Transcription factors as potential targets for therapeutic drugs. (2000) (28)
Relative importance of different human aPL derived heavy and light chains in the binding of aPL to cardiolipin. (2003) (28)
p73-mediated transcriptional activity is negatively regulated by Polo-like kinase 1 (2008) (27)
Retinoic acid inhibits both the basal activity and phorbol ester‐mediated activation of the HIV long terminal repeat promoter (1995) (27)
Brn-3a transcription factor blocks p53-mediated activation of proapoptotic target genes Noxa and Bax in vitro and in vivo to determine cell fate. (2015) (27)
Promoter-independent activation of heterologous virus gene expression by the herpes simplex virus immediate-early protein ICP27. (1992) (27)
Brn-3a neuronal transcription factor functional expression in human prostate cancer (2006) (27)
The critical role of arginine residues in the binding of human monoclonal antibodies to cardiolipin (2003) (27)
How do antiphospholipid antibodies bind beta2-glycoprotein I? (2003) (26)
Cardioprotection mediated by urocortin is dependent upon PKCε activation (2005) (26)
Differential regulation of neuronal nicotinic acetylcholine receptor subunit gene promoters by Brn-3 POU family transcription factors. (1996) (26)
Antagonistic effects of retinoic acid and thyroid hormone on the expression of the tissue-specific splicing protein SmN in a clonal cell line derived from rat heart. (1994) (26)
Hsf1-Mediated Stress Response can Transiently Enhance Cellular Radioresistance (2006) (26)
The tissue specific elevation in synthesis of the 90 kDa heat shock protein precedes the onset of disease in lupus prone MRL/lpr mice. (1994) (26)
Potential and limitations of a γ34.5 mutant of herpes simplex 1 as a gene therapy vector in the CNS (1998) (26)
CREB-binding protein activation by presenilin 1 but not by its M146L mutant (2006) (26)
Inhibition of herpes simplex virus infection by ectopic expression of neuronal splice variants of the Oct-2 transcription factor. (1994) (26)
STAT1 regulates p73‐mediated Bax gene expression (2007) (26)
The cardioprotective agent urocortin induces expression of CT-1 (2007) (25)
Analysis of the association of a heat shock protein70-1 gene promoter polymorphism with myocardial infarction and coronary risk traits. (1998) (25)
The role of hsp90 in SLE. (1994) (25)
Induction and repression of cellular gene transcription during herpes simplex virus infection are mediated by different viral immediate-early gene products. (1988) (25)
Endothelial microparticle release is stimulated in vitro by purified IgG from patients with the antiphospholipid syndrome (2012) (24)
The Brn-3a transcription factor plays a key role in regulating the growth of cervical cancer cells in vivo (2001) (24)
Cell lines derived from dorsal root ganglion neurons are nonpermissive for HSV and express only the latency-associated transcript following infection. (1990) (24)
Thrombin Binding Predicts the Effects of Sequence Changes in a Human Monoclonal Antiphospholipid Antibody on Its In Vivo Biologic Actions 1 (2009) (24)
A single residue within the homeodomain of the Brn‐3 POU family transcription factors determines whether they activate or repress the SNAP‐25 promoter (1997) (23)
Retracted: Cardiac release of urocortin precedes the occurrence of irreversible myocardial damage in the rat heart exposed to ischemia/reperfusion injury (2008) (23)
Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter. (2002) (23)
Protective Effect of Post-Ischaemic Viral Delivery of Heat Shock Proteins in vivo (2009) (23)
Elevation of cyclic AMP levels in cell lines derived from latently infectable sensory neurons increases their permissivity for herpes virus infection by activating the viral immediate-early 1 gene promoter. (1992) (22)
Viral Vectors for Gene Therapy in Parkinson's Disease (2001) (22)
Coexpression of Brn‐3a POU protein with p53 in a population of neuronal progenitor cells is associated with differentiation and protection against apoptosis (2004) (22)
Expression of the SmN splicing protein is developmentally regulated in the rodent brain but not in the rodent heart. (1993) (22)
Bcl-2 expression is unaltered in unfractionated peripheral blood mononuclear cells in patients with systemic lupus erythematosus. (1995) (22)
An improved rapid method for mitochondrial DNA isolation suitable for use in the study of closely related populations (1988) (21)
Bio-electrospraying primary cardiac cells: in vitro tissue creation and functional study. (2011) (21)
The herpes simplex virus type 1 immediate-early protein ICP4 specifically induces increased transcription of the human ubiquitin B gene without affecting the ubiquitin A and C genes. (1988) (21)
Proliferation-associated Brn-3b transcription factor can activate cyclin D1 expression in neuroblastoma and breast cancer cells (2008) (21)
Nuclear accumulation of a heat-shock 70-like protein during herpes simplex virus replication (1987) (21)
The Pro-Oncoprotein EWS (Ewing’s Sarcoma Protein) Interacts with the Brn-3a POU Transcription Factor and Inhibits its Ability Activate Transcription (2002) (21)
Properties of whole human IgG molecules produced by the expression of cloned anti-DNA antibody cDNA in mammalian cells. (1998) (21)
Brn-3a transcription factor blocks p53-mediated activation of proapoptotic target genes Noxa and Bax in vitro and in vivo to determine cell fate. (2005) (21)
Herpes simplex virus-based vectors for the treatment of cancer and neurodegenerative disease. (2005) (21)
Activation of the iNOS gene promoter by Brn-3 POU family transcription factors is dependent upon the octamer motif in the promoter. (1998) (21)
Down regulation of the octamer binding protein Oct-1 during growth arrest and differentiation of a neuronal cell line. (1995) (21)
Isolation of cDNA clones encoding the human Sm B/B′auto‐immune antigen and specifically reacting with human anti‐Sm auto‐immune sera (1989) (20)
Stress Proteins: An Overview (1998) (20)
The herpes simplex virus 2 kb latency associated transcript (LAT) leader sequence allows efficient expression of downstream proteins which is enhanced in neuronal cells: possible function of LAT ORFs. (1998) (20)
Reduction in endogenous parkin levels renders glial cells sensitive to both caspase‐dependent and caspase‐independent cell death (2004) (20)
Transcriptional induction of cellular gene expression during lytic infection with herpes simplex virus (1986) (20)
Activation and repression of gene expression by POU family transcription factors. (1996) (20)
The levels of the antagonistic POU family transcription factors Brn-3a and Brn-3b in neuronal cells are regulated in opposite directions by serum growth factors (1995) (20)
Levels of the 90kd heat shock protein and resistance to glucocorticoid-mediated cell killing in a range of human and murine lymphocyte cell lines. (1989) (19)
Autophagy in the stress-induced myocardium. (2012) (19)
Ct-1 and Oct-2 DNA-binding site specificity is regulated in vitro by different kinases. (1996) (19)
Changes in regulation of human monocyte proteins in response to IgG from patients with antiphospholipid syndrome. (2014) (19)
Heat Shock Proteins and Human Disease (1991) (19)
Nerve growth factor induces the Oct‐2 transcription factor in sensory neurons with the kinetics of an immediate‐early gene (1995) (19)
Heat shock protein-56 is induced by cardiotrophin-1 and mediates its hypertrophic effect. (2001) (19)
Cell stress genes and neuronal protection (1995) (19)
Nutritional supplementation with mixed essential amino acids enhances myocyte survival, preserving mitochondrial functional capacity during ischemia-reperfusion injury. (2004) (19)
Molecular Cloning and Expression of the Fabs of Human Autoantibodies in Escherichia coli (2000) (19)
NT-3 regulates expression of Brn3a but not Brn3b in developing mouse trigeminal sensory neurons. (1998) (18)
Correction: PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons (2008) (18)
p300 activation by Presenilin 1 but not by its M146L mutant (2007) (18)
Somatic mutations to arginine residues affect the binding of human monoclonal antibodies to DNA, histones, SmD and Ro antigen. (2004) (18)
Modulation of cell death by α-synuclein is stimulus-dependent in mammalian cells (2003) (18)
Stable expression of a recombinant human antinucleosome antibody to investigate relationships between antibody sequence, binding properties, and pathogenicity (2005) (18)
Activation of the herpes simplex virus immediate-early gene promoters by neuronally expressed POU family transcription factors. (1995) (18)
Differential regulation of different human papilloma virus variants by the POU family transcription factor Brn-3a (2006) (17)
The role of minocycline in ischemia-reperfusion injury: a comprehensive review of an old drug with new implications. (2011) (17)
The molecular basis of adaptation to ischemia in the heart: the role of stress proteins and anti-oxidants in the ischemic and reperfused heart. (1996) (17)
Evaluating the conformation of recombinant domain I of β2-glycoprotein I and its interaction with human monoclonal antibodies (2011) (17)
Anti-factor Xa antibodies in patients with antiphospholipid syndrome and their effects upon coagulation assays (2015) (17)
Elevation of the 90 kDa heat-shock protein in specific subsets of systemic lupus erythematosus. (1994) (17)
Expression of the Fabs of human auto-antibodies in Escherichia coli: optimization and determination of their fine binding characteristics and cross-reactivity. (2001) (17)
The constitutively expressed octamer binding protein OTF-1 and a novel octamer binding protein expressed specifically in cervical cells bind to an octamer-related sequence in the human papillomavirus 16 enhancer. (1991) (17)
The Different Activities of the Two Activation Domains of the Brn-3a Transcription Factor Are Dependent on the Context of the Binding Site (*) (1996) (17)
FLIP protects cardiomyocytes from apoptosis induced by simulated ischemia/reoxygenation, as demonstrated by short hairpin-induced (shRNA) silencing of FLIP mRNA. (2003) (17)
Herpes simplex virus-based vectors (1995) (17)
Molecular cloning of a human neuronal nicotinic acetylcholine receptor β3-like subunit (1993) (16)
Regulated expression of the small nuclear ribonucleoprotein particle protein SmN in embryonic stem cell differentiation (1990) (16)
Regulation Of Brn-3a N-terminal transcriptional activity by MEK1/2-ERK1/2 signalling in neural differentiation (2009) (16)
The Brn-3a POU family transcription factor stimulates p53 gene expression in human and mouse tumour cells (2002) (16)
Green tea polyphenol epigallocatechin gallate inhibits cell signaling by inducing SOCS1 gene expression. (2010) (16)
Targeting Brn-3b in breast cancer therapy (2006) (15)
Gene expression studies on bio‐electrosprayed primary cardiac myocytes (2008) (15)
Expression of the SmB′ splicing protein in rodent cells capable of following an alternative RNA splicing pathway (1989) (15)
Cellular gene induction during herpes simplex virus infection can occur without viral protein synthesis. (1986) (15)
The cardioprotective effects of urocortin are mediated via activation of the Src tyrosine kinase-STAT3 pathway (2013) (15)
Protection of neuronal and cardiac cells by HSP27. (2002) (15)
How can we use our growing understanding of gene transcription to discover effective new medicines? (1997) (15)
Interferon-alpha treatment of Daudi cells down-regulates the octamer binding transcription/DNA replication factors Oct-1 and Oct-2. (1991) (15)
Heat shock proteins can protect aged human and rodent cells from different stressful stimuli (2004) (15)
Functional interaction between different isoforms of the Oct-2 transcription factor expressed in neuronal cells. (1994) (14)
The Urocortins: mechanisms of cardioprotection and therapeutic potential. (2006) (14)
Measurement of Brn-3a levels in Pap smears provides a novel diagnostic marker for the detection of cervical neoplasia. (2003) (14)
Interactions of human monoclonal and polyclonal antiphospholipid antibodies with serine proteases involved in hemostasis (2011) (14)
Specific up-regulation of the POU domain transcription factor Oct-2 following axotomy (1996) (14)
Current status review: molecular biology of herpes simplex virus latency. (1990) (14)
Distinct serine residues in CBP and p300 are necessary for their activation by phenylephrine. (2004) (13)
The snRNP core protein SmB and tissue-specific SmN protein are differentially distributed between snRNP particles. (1993) (13)
Analysis of three new idiotypes on human monoclonal autoantibodies (1995) (13)
Cell type specific repression of the varicella zoster virus immediate early gene 62 promoter by the cellular Oct-2 transcription factor. (1998) (13)
Signal-transduction pathways involved in the hypertrophic effect of hsp56 in neonatal cardiomyocytes. (2004) (13)
Differential regulation of octamer‐containing cellular genes by the herpes simplex virus virion protein Vmw65 is mediated by sequence differences in the octamer element. (1988) (13)
Regulation of myocardial interleukin-6 expression by p53 and STAT1. (2013) (13)
The herpes simplex virus type 1 immediate-early protein ICP27 is obligately required for the accumulation of a cellular protein during viral infection. (1989) (13)
A cellular factor binding to the TAATGARAT DNA sequence prevents the expression of the HSV immediate-early genes following infection of nonpermissive cell lines derived from dorsal root ganglion neurons. (1991) (13)
A human anti‐dsDNA monoclonal antibody caused hyaline thrombi formation in kidneys of ‘leaky’ SCID mice (2001) (13)
Identification and Characterization of a New Human DNA Reactive Monoclonal Antibody and a Common Idiotype, WRI 176 Id β (1994) (13)
The ability of POU family transcription factors to activate or repress gene expression is dependent on the spacing and context of their specific response elements. (1996) (13)
Arginine mutation alters binding of a human monoclonal antibody to antigens linked to systemic lupus erythematosus and the antiphospholipid syndrome. (2007) (13)
The overlapping octamer/TAATGARAT motif is a high-affinity binding site for the cellular transcription factors Oct-1 and Oct-2. (1991) (13)
Alternative splicing of the Brn-3a and Brn-3b transcription factor RNAs is regulated in neuronal cells (2007) (13)
The differential expression of heat shock proteins in rheumatic disease. (1993) (13)
Cell-type-specific splicing factors and the regulation of alternative RNA splicing. (1990) (13)
The different competitive abilities of viral TAATGARAT elements and cellular octamer motifs, mediate the induction of viral immediate-early genes and the repression of the histone H2B gene in herpes simplex virus infected cells. (1989) (12)
Cardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expression (2008) (12)
Effect of herpes simplex virus type 2 infection on mitochondrial gene expression. (1988) (12)
The cellular transcription factor Brn-3a and the smoking-related substance nicotine interact to regulate the activity of the HPV URR in the cervix (2010) (12)
Brn-3a Transcription Factor Blocks p53-mediated Activation of Proapoptotic Target Genes Noxa and Bax in Vitro and in Vivo to Determine Cell Fate* (2005) (12)
Amino acid supplementation differentially modulates STAT1 and STAT3 activation in the myocardium exposed to ischemia/reperfusion injury. (2008) (12)
A Simple Technique for the Prediction of Interacting Proteins Reveals a Direct Brn-3a-Androgen Receptor Interaction* (2010) (12)
Review: Heat Shock Proteins and Systemic Lupus Erythematosus (1991) (12)
PCR applications in pathology : principles and practice (1995) (11)
WHOLE-BODY HEAT-STRESS PROTECTS THE ISOLATED PERFUSED RABBIT HEART (1990) (11)
Widespread elevated expression of the human papilloma virus (HPV)-activating cellular transcription factor Brn-3a in the cervix of women with CIN3 (cervical intraepithelial neoplasia stage 3). (2000) (11)
Expression of the tissue specific splicing protein SmN in neuronal cell lines and in regions of the brain with different splicing capacities. (1992) (11)
The cardiac form of the tissue-specific SmN protein is identical to the brain and embryonic forms of the protein. (1993) (11)
Genetic structural and functional properties of a human IgG anti-DNA autoantibody (1996) (11)
A filamentous distribution for the herpes simplex virus type 2-encoded major DNA-binding protein. (1986) (11)
Post‐transcriptional regulation of the Brn‐3b transcription factor in differentiating neuroblastoma cells (2007) (10)
Altered dinucleotide content within the latently transcribed regions of the DNA of alpha herpes viruses--implications for latent RNA expression and DNA structure. (1995) (10)
Germline gene therapy? (1994) (10)
Book Review: Gene Therapy with Herpes Simplex Virus Vectors: Progress and Prospects for Clinical Neuroscience (2001) (10)
Pharmacological attenuation of apoptosis in reoxygenated endothelial cells (2004) (10)
Cell-specific regulation of the pro-survival Brn-3b transcription factor by microRNAs (2010) (10)
A case of fatal ephedra intake associated with lipofuscin accumulation, caspase activation and cleavage of myofibrillary proteins (2005) (10)
Doppel expression is regulated by the Brn-3a and Brn-3b transcription factors (2004) (10)
Neuroprotective effects of copper/zinc-dependent superoxide dismutase against a wide variety of death-inducing stimuli and proapoptotic effect of familial amyotrophic lateral sclerosis mutations. (2002) (10)
Elevation of the levels of SmB, B' and D proteins but not that of the La (SS-B) antigen during HSV infections. (1989) (10)
EWS differentially activates transcription of the Brn-3a long and short isoform mRNAs from distinct promoters. (2004) (10)
STAT signalling in the heart and cardioprotection (2006) (10)
Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor (2003) (9)
The herpes simplex virus protein Vmw65 can trans-activate both viral and cellular promoters in neuronal cells. (1990) (9)
The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivo. (2004) (9)
Regulation of NGFI-A (Egr-1) gene expression by the POU domain transcription factor Brn-3a. (1999) (9)
Functional role of position 22 in the homeodomain of Brn‐3 transcription factors (1998) (9)
Cloning and sequencing of a mouse embryonal carcinoma cell mRNA encoding the tissue specific RNA splicing protein SmN. (1991) (9)
Brn-3a/POU4F1 interacts with and differentially affects p73-mediated transcription (2008) (9)
The TAATGARAT Motif in the Herpes Simplex Virus Immediate-Early Gene Promoters Can Confer both Positive and Negative Responses to Cellular Octamer-Binding Proteins When It Is Located within the Viral Genome (1998) (9)
The NF-IL6 and STAT-3 signalling pathways co-operate to mediate the activation of the hsp90( gene by IL-6 but have opposite effects on its inducibility by heat shock (1998) (9)
Regulated splicing of the Oct-2 transcription factor RNA in neuronal cells (1995) (8)
Elevated expression of the Brn-3a and Brn-3b transcription factors in systemic lupus erythematosus correlates with antibodies to Brn-3 and overexpression of Hsp90. (2005) (8)
Transcription of the genes encoding the small heat shock protein ubiquitin is unchanged in patients with systemic lupus erythematosus. (1992) (8)
Distinct domains of Brn-3a regulate apoptosis and neurite outgrowth in vivo (2004) (8)
Herpes virus vectors for gene therapy in the nervous system. (1999) (8)
Adjacent proline residues in the inhibitory domain of the Oct-2 transcription factor play distinct functional roles. (1998) (7)
Brn-3 b enhances the pro-apoptotic effects of p 53 but not its induction of cell cycle arrest by cooperating in transactivation of bax expression (2006) (7)
Anti-apoptotic activity of the free card domain of procaspase-9: A novel endogenous rescue pathway (2002) (7)
The HPV activating transcription factor Brn-3a is over expressed in CIN3 lesions (1998) (7)
Phosphorylation of the Brn-3a transcription factor is modulated during differentiation and regulates its functional activity. (2005) (7)
Transactivation by the herpes simplex virus virion protein Vmw65 and viral permissivity in a neuronal cell line with reduced levels of the cellular transcription factor Oct-1. (1993) (7)
The Expression of Heat Shock Proteins in Systemic Lupus Erythematosus (1994) (7)
Redistribution of secretory granule components precedes that of synaptic vesicle proteins during differentiation of a neuronal cell line in serum-free medium (1992) (7)
Cell cycle arrest and morphological differentiation can occur in the absence of apoptosis in a neuronal cell line (1994) (6)
STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage (2015) (6)
The human Mr 90,000 heat shock protein and the Escherichia coli Lon protein share an antigenic determinant. (1987) (6)
Immediate upstream promoter regions required for neurospecific expression of SNAP-25 (1995) (6)
Regulation of herpes simplex virus immediate-early gene promoters in mouse neuroblastoma cells (1990) (6)
Fine binding characteristics of human autoantibodies-partial molecular characterization. (2004) (5)
Sensory neurons from mice lacking the Brn-3b POU family transcription factor are resistant to death-inducing stimuli both in vitro and in vivo. (2003) (5)
Nerve growth factor treatment of sensory neuron primary cultures causes elevated levels of the mRNA encoding the ATP synthase beta-subunit as detected by a novel PCR-based differential cloning method. (1996) (5)
Anti-cardiolipin/beta-2 glycoprotein activities co-exist on human anti-DNA antibody light chains. (2003) (5)
Ischaemic preconditioning causes rapid elevation of 65kDa stress protein in rabbit heart (1992) (5)
Alternative splicing of the mRNA encoding the α subunits of the Go GTP-binding protein during brain development and in neuronal cell lines (1993) (5)
Interleukin-10 activates heat shock protein 90 (HSP90) gene expression. (1998) (5)
Differential regulation of genes encoding synaptic proteins by the Oct-2 transcription factor. (1997) (5)
Herpes simplex virus vectors for Parkinson's disease. (2003) (5)
Basic Molecular and Cell Biology (1994) (5)
POU family transcription factors in sensory neurons. (1992) (5)
Regulation of Transcription Factor Activity (2004) (5)
Detection of cervical abnormalities in a developing country using measurement of Brn-3a in cervical smears. (2006) (5)
Induction of the Oct-2 transcription factor in primary sensory neurons during inflammation is nerve growth factor-dependent (1996) (5)
Growth of herpes simplex virus and purification of viral DNA. (1992) (5)
Detection of cervical neoplasia using measurement of Brn‐3a in cervical smears with persistent minor abnormality (2003) (5)
Regulation of neuroblastoma growth and differentiation by the POU family transcription factors Brn-3a and Brn-3b (Review). (1997) (5)
An improved method for the isolation of high yields of bacteriophage lambda DNA. (1986) (5)
The different alternatively spliced isoforms of the Oct-2 transcription factor repress the involucrin promoter in a cell type-specific manner (1998) (5)
From genetics to gene therapy : the molecular pathology of human disease (1994) (5)
18 The N-terminal domain unique to the long form of the Brn-3a transcription factor is essential to protect neuronal cells from apoptosis and for the activation of Bcl-2 gene (1998) (5)
Serum nitrated nucleosome levels in patients with systemic lupus erythematosus: a retrospective longitudinal cohort study (2014) (5)
Inhibition of histone H2B gene transcription and of cellular growth by a truncated viral trans-activator protein. (1990) (5)
FKBP12 mRNA expression is upregulated by intrinsic CNS neurons regenerating axons into peripheral nerve grafts in the brain (2003) (4)
TheB-Cell andNeuronal FormsoftheOctamer-Binding Protein Oct-2Differ inDNA-Binding Specificity andFunctional Activity (1991) (4)
EWS/ETS proteins promote expression and regulate function of the homeodomain transcription factor BRN3A (2010) (4)
Expression of the α-fetoprotein gene in pluripotent and committed cells (1984) (4)
Gene regulation. (1992) (4)
Heat-shock proteins (1991) (4)
DIFFERENCES IN THE ABILITY OF TRANSFECTED HSP70 AND HSP90 GENES TO PROTECT H9C2 MYOCYTES AGAINST HET STRESS AND HYPOXIA (1994) (4)
Direct evidence that the POU family transcription factor Oct-2 represses the cellular tyrosine hydroxylase gene in neuronal cells (2007) (4)
Cardiotrophin-1 reduces infarct size in isolated heart model via a MAP kinase dependent pathway (1999) (4)
Optimisation of herpes simplex virus-based vectors for delivery to human peripheral blood mononuclear cells. (2002) (4)
Gene therapy using herpes simplex virus-based vectors. (2000) (4)
Activation of endogenous retroviral transcription in SV40-transformed mouse cells. (1991) (4)
Analysis of Neuronal Gene Regulation and Differentiation Using the ND (Neuroblastoma-Dorsal Root Ganglion) Series of Cell Lines (1995) (3)
Gene Therapy with Virus Vectors for specific Disease of the Nervous System (2003) (3)
Antiapoptotic Activity of the Free Caspase Recruitment Domain of Procaspase-9 (2002) (3)
Expression of the alpha-fetoprotein gene in pluripotent and committed cells. (1984) (3)
Insulin modifies myocyte apoptosis and reduces myocardial infarct size when administered at reperfusion: A novel mechanism of protection (1999) (3)
Herpes Simplex Virus Latency and Immediate Early Gene Repression by the Cellular Octamer-Binding Protein Oct-2 (1994) (3)
Representational difference analysis of cDNA identifies novel genes expressed following preconditioning of the heart (2005) (3)
METHODS FOR STUDYING TRANSCRIPTION FACTORS (2004) (3)
Trans-Acting Factors (2001) (3)
The Brn-3b Transcription Factor Regulates the Growth, Behavior, and Invasiveness of Human Neuroblastoma Cells in Vitro and in Vivo* (2004) (3)
Identification and characterization of a new human DNA reactive monoclonal antibody and a common idiotype, WRI 176 Id beta. (1994) (3)
Voltage-Gated Sodium Channel Expression and Potentiation of Human Breast CancerMetastasis (2005) (3)
DNA Sequences, Transcription Factors and Chromatin Structure (2004) (3)
Cloning and sequencing of the rat Oct-1 POU box (1991) (3)
SPECIFIC INDUCTION OF HSP72 BY HERBIMYCIN-A PROTECTS CARDIOMYOCYTES - A PHARMACOLOGICAL ROUTE TO CYTOPROTECTION (1995) (3)
Transcriptional regulation of viral gene expression (1993) (3)
FAMILIES OF DNA BINDING TRANSCRIPTION FACTORS (2008) (3)
Herpes simplex virus vectors for gene delivery to a variety of different cell types. (2002) (3)
Beta-2-glycoprotein specificity of human anti-phospholipid antibody resides on the light chain: a novel mechanism for acquisition of cross-reactivity by an autoantibody. (2005) (3)
Oestrogen enhances the responsiveness of the MMTV-LTR to glucocorticoid in ZR-75-1 human breast cancer cells. (1990) (3)
Distinct responses of the herpes simplex virus and varicella zoster virus immediate early promoters to the cellular transcription factors Brn-3a and Brn-3b. (1999) (3)
ACTIVATION OF GENE EXPRESSION BY TRANSCRIPTION FACTORS (2004) (3)
Enhanced transcription of the gene encoding the SmN autoantigen in patients with systemic lupus erythematosus does not result in enhanced levels of the SmN protein. (1994) (3)
Modulation of cell death by alpha-synuclein is stimulus-dependent in mammalian cells. (2003) (3)
The HPV Cellular Transactivator Brn-3a Can Be Used to Predict Cervical Adenocarcinoma and Squamous Carcinoma Precancer Lesions in the Developed and Developing Worlds (2010) (3)
A rapid method for analysis of the products of in vitro translation of messenger RNA. (1983) (3)
ERK and the F-box protein β TRCP target STAT1 for degradation. (2018) (3)
The inhibitory domain in the Oct-2 transcription factor represses gene activity in a cell type-specific and promoter-independent manner (2004) (2)
TRANSCRIPTION FACTORS AND HUMAN DISEASE (2004) (2)
Transgenic overexpression of HSP56 does not result in cardiac hypertrophy nor protect from ischaemia/reperfusion injury. (2011) (2)
RNA Polymerases and the Basal Transcriptional Complex (2004) (2)
Expression of the 90 kD heat shock protein in Behçet's syndrome. (1992) (2)
Expression of the tissue specific RNA splicing protein SmN in HeLa cells. (1990) (2)
Antiapoptotic activity of the free caspase recruitment domain of procaspase-9: A NOVEL ENDOGENOUS RESCUE PATHWAY IN CELL DEATH. (2002) (2)
Gene delivery to rat enteric neurons using herpes simplex virus-based vectors (1997) (2)
HERPES SIMPLEX VIRUS AND RISK OF ALZHEIMER'S DISEASE. AUTHORS' REPLY (1997) (2)
Gene therapy with herpes simplex virus vectors. (1999) (2)
Approaches To the Biochemistry of Differentiation of Mouse Embryonal Carcinoma Cells (1983) (2)
Chapter 4 – Families of DNA Binding Transcription Factors (2004) (2)
Cardioprotective role of insulin at reperfusion may in part be due to an anti-apoptotic mechanism (1999) (2)
Functional interaction between Brn-3a and Src-1 co-activates Brn-3a-mediated transactivation. (2002) (2)
Towards evidence-based typography: First results (2012) (2)
Mice lackingSnrpn expression show normal regulation of neuronal alternative splicing events (1994) (2)
The two activation domains of the Brn-3a transcription factor have distinct functional properties (1997) (2)
The light chain of a human monoclonal antiphospholipid antibody has a dramatic influence on its functional properties in an in vivo mouse model (2006) (2)
Chapter 8 – Regulation of Transcription Factor Activity (2004) (2)
The effect of Heat Stress on infarct size in blood vs buffer perfused rabbit hearts (1992) (2)
No diabetes link to hsp65? (1992) (2)
The intronless mouse gene for the tissue specific splicing protein SmN is a processed pseudogene containing a stop codon after thirty-one amino acids. (1992) (2)
Differential expression of the mouse U1a and U1b SnRNA genes is not dependent on sequence differences in the octamer motif. (1991) (2)
Transforming growth factor beta 1 attenuates myocardial injury when given at reperfusion (1999) (2)
Cellular polypeptides overexpressed after herpes simplex infection permit virus subtyping and may help diagnose cervical cancer. (1988) (2)
Neuronal expression of the tissue specific splicing protein SmN and its possible role in pre mRNA splicing. (1992) (1)
The effect of aging on the ability to protect the rat heart from ischaemia/reperfusion injury. (2000) (1)
Detection of cervical neoplasia using measurement of Brn-3a in cervical smears with persistent minor abnormality (2003) (1)
Identification of PINK1, the first mitochondrial gene causing Parkinson's disease (2004) (1)
HSP expression and protection after heat stress in myogenic cells, and after simulated ischemia in cardiomyocytes, are protein kinase C-dependent. (1996) (1)
1P-0171 Hsp70 or Hsp27 overexpressed in endothelial cells during post-ischemic reperfusion may protect from delayed apoptosis (2003) (1)
REGULATION OF TRANSCRIPTION FACTOR SYNTHESIS (2004) (1)
The activation of cellular genes in transformed cells. (1984) (1)
The Epigenome: Role of Chromatin Structure in Gene Control (2020) (1)
Metal Response Element (2002) (1)
Landmarks in gene regulation. (1997) (1)
Chapter 5 – Activation of Gene Expression by Transcription Factors (2004) (1)
Hormone Response Elements (2002) (1)
Detection in non-erythroid cells of a factor with the binding characteristics of the erythroid cell transcription factor EF1. (1990) (1)
Multiply disabled herpes simplex virus vectors for gene delivery to the central nervous system (2000) (1)
Cell-type specific expression of the SmB' splicing protein and alternative RNA splicing (1989) (1)
Development of Herpes Simplex Virus-1 based vectors for gene delivery to sensory neurons in vivo to elucidate the role of neurotrophins and neuropeptides in chronic pain states. (2000) (1)
THE FAILURE OF WHOLE-BODY HEAT-SHOCK TO LIMIT INFARCT SIZE IN THE ISCHEMIC AND REPERFUSED RABBIT HEART (1991) (1)
A potential role for U1 RNA genes in gene duplication and conversion events (1988) (1)
Regulation of viral and cellular gene expression in sensory neurons. (1994) (1)
Serum Response Element (2002) (1)
NT-3 regulates expression of Brn-3a but not Brn-3b during the development of mouse trigeminal sensory neurons (1998) (1)
Thoracic and Cardiovascular (2003) (1)
Herpes simplex virus life cycle and the design of viral vectors. (1992) (1)
PINK1: a novel mitochondrial protein in Parkinson's disease (2006) (1)
Post-transcriptional regulation of the Brn-3b transcription factor (2006) (1)
Examination of the potential interactions between herpes simplex virus vectors and replication-competent virus in vitro and in vivo (2003) (1)
Molecular expression systems for anti-DNA antibodies—2 (2002) (1)
MYOCARDIAL RESISTANCE TO HYPOXIA IS RELATED TO THE CONTENT OF THE 72KDA STRESS PROTEIN (1992) (1)
Transcription Factors and Transcriptional Control (2020) (1)
The tissue specific SmN protein does not influence the alternative splicing of endogenous N-Cam and C-SRC RNAs in transfected 3T3 cells. (1993) (1)
The use of cDNA cloning techniques to isolate genes activated in tumour cells. (1983) (1)
Regulation of neuronal differentiation and apoptosis by Brn-3 POU family transcription factors :-potential use in gene therapy ( review ) (2009) (1)
Purified IgG from patients with different clinical manifestations of the antiphospholipid syndrome have differential effects upon the NF-kappa B and p38MAPK signalling pathways in monocytes (2007) (1)
Chapter 1 – DNA Sequences, Transcription Factors and Chromatin Structure (2004) (1)
Chapter 3 – RNA Polymerases and the Basal Transcriptional Complex (2004) (1)
POU 4 F 1 ( POU class 4 homeobox 1 ) (2011) (0)
A site-directed mutagenesis study of putative cleavage sites of the Parkinson's disease associated gene, PINK1 (2006) (0)
The Process of Transcription (2020) (0)
Cytoplasmic/nuclear relocation of myocyte BAG-1 provides endogenous cardiprotection in the intact rat heart exposed to ischemia/reperfusion injury (2005) (0)
Corrigendum (2016) (0)
Molecular cloning. Expression and functional evaluation of the recombinant Fabs of human anti-DNA (B3) and anti-cardiolipin (UK4) antibodies and their hybrids. (1999) (0)
The resistance of rabbit papillary muscle to high flow hypoxia is enhanced by heat stress when pyruvate is used as substrate (1992) (0)
Biological sciences (1990) (0)
Arginine residues in human monoclonal antiphospholipid antibodies are important in determining their ability to bind and affect the function of antigens relevant to the pathogenesis of atherosclerosis in the antiphospholipid syndrome (2007) (0)
Potential cardioprotective role of insulin at reperfusion by a possible anti-apoptotic mechanism (1999) (0)
Control of Cell Type-Specific Gene Expression (2020) (0)
attenuate proteotoxicity of cellular ATP depletion Stressful preconditioning and HSP70 overexpression (2016) (0)
Brn Transcription Factors (2002) (0)
Regulation of BRCA-1 Gene Expression and Mammary Tumorigenesis by the Brn-3b POU Family Transcription Factor (2000) (0)
Molecular Chaperones and Cell Signalling: Molecular Chaperone–Cytokine Interactions at the Transcriptional Level (2005) (0)
Warm blood cardioplegia induces mitochondria- initiated myocyte apoptosis which is ameliorated by overexpression of endogeneous urocortin (2003) (0)
Gene Control (2020) (0)
Gene Control In Embryonic Development (2018) (0)
Sequence motifs in a human monoclonal Antiphospholipid antibody determine its ability to bind and affect the function of serine proteases (2008) (0)
Chapter 6 – Repression of Gene Expression by Transcription Factors (2004) (0)
Identifying the promoter region of the human Nav1.7 voltage-gated sodium channel gene (scn9a) (2006) (0)
Relative contribution of the mitochondria and death receptor signaling pathways in cardiac apoptosis during ischaemia versus reperfusion injury (2001) (0)
Diagnostic du cancer du col de l'uterus (2002) (0)
Polyclonal igg from patients with the APS stimulate the production of endothelial microparticles in an in vitro assay (2008) (0)
Correction: Proliferation-associated Brn-3b transcription factor can activate cyclin D1 expression in neuroblastoma and breast cancer cells (2023) (0)
Chapter 9 – Transcription Factors and Human Disease (2004) (0)
Chapter 7 Alternative RNA splicing (1996) (0)
In Vivo and in Vitro Vascular Gene Transfer of Timp-1 Using an Adenoviral Vector (1997) (0)
Green tea regulates cell signalling by inducing SOCS1 gene expression via its constituent polyphenol EGCG (2009) (0)
Post-transcriptional Regulation (2007) (0)
Characterisation of genomic and cDNA clones of the small ribonucleoprotein SmN (1991) (0)
Comprar Gene Control | David S. Latchman | 9780815365136 | Garland Science (2010) (0)
REPRESSION OF GENE EXPRESSION BY TRANSCRIPTION FACTORS (2004) (0)
Oct (Octamer‐Binding Proteins) Transcription Factors (2002) (0)
Gene Regulation and Human Disease (2020) (0)
Bid for the top (1990) (0)
Ischaemia-induced STAT-1 activation plays a role in the induction of Fas/FasL in cardiac myocytes by p38 mitogen-activated protein kinase and c-Jun kinase pathways (2001) (0)
Chapter 6 Transcription Factors (1996) (0)
HSV-1 viral vectors for the peripheral nervous system: Delivery of potentially regenerative molecules (2000) (0)
PREFACE TO THE FOURTH EDITION (2008) (0)
REGULATION OF INTRACELLULAR-LOCALIZATION OF CHROMOGRANINS AND SYNAPTOPHYSIN IN NEURONAL CELL-LINES (1991) (0)
Chapter 2 – Methods for Studying Transcription Factors (2004) (0)
The s(p)elling of apo(p)tosis (1995) (0)
Hsv originating with lack of functional ICP27 and ICP34.5 genes (1997) (0)
VH GENE USAGE IN HUMAN HUMAN HYBRIDOMA DERIVED MONOCLONAL-ANTIBODIES FROM SLE PATIENTS (1992) (0)
Urocortin (UCN) protects the heart from reperfusion injury via activation of the p42/44 mitogen activated protein kinase (MAPK) pathway: A possible reperfusion injury salvage kinase (RISK) (2001) (0)
THROMBOSIS AND HEMOSTASIS Changes in regulation of human monocyte proteins in response to IgG from patients with antiphospholipid syndrome (2014) (0)
SPECIFICITY AND CLINICAL RELEVANCE OF HEAT-SHOCK PROTEIN OVEREXPRESSION IN SYSTEMIC LUPUS-ERYTHEMATOSUS (1992) (0)
Transcription factors: an overview. (1993) (0)
Temporal expression and characterisation of a testis expressed mRNA (1990) (0)
Chapter 7 – Regulation of Transcription Factor Synthesis (2004) (0)
Exploring the nature of the interaction between human monoclonal antiphospholipid antibodies and Domain I of beta-2-glycoprotein I (2006) (0)
Retraction notice to “Enhanced IL-17 signalling following myocardial ischaemia/reperfusion injury” [Int. J. Cardiol. 163 (2013) 326–334] (2019) (0)
Bag-1 relocates within cardiac myocytes following ischemia/reperfusion and prevents myocyte apoptosis by interaction with Hsc70 (2003) (0)
Signaling Pathways Antiphospholipid Syndrome on Monocyte Patients with Different Clinical Types of the Effects of Polyclonal IgG Derived from (2010) (0)
LEVELS OF AN IGG ANTI-DNA IDIOTYPE FLUCTUATE WITH MUSCULOSKELETAL DISEASE IN SLE PATIENTS (1993) (0)
Molecular biology of stress proteins (1991) (0)
Gene Regulation and Cancer (2018) (0)
Corrigendum to “Hypertrophic effects of urocortin homologous peptides are mediated via activation of the Akt pathway” [Biochem. Biophys. Res. Commun. 328 (2005) 442–448] (2005) (0)
Ischemia in the Isolated Rat Heart: A Hypothetical Cut Off Point for Experimental Simulated Angina? (2002) (0)
Levels of Gene Control (2018) (0)
The herpes simplex virus virion protein Vmw65 transcriptionally activates the gene encoding the U4 snRNA but not that encoding the U2 snRNA during lytic infection. (1991) (0)
Occurrence of apoptosis in specific cell types in isolated perfused rat hearts exposed to ischaemia and reperfusion (1999) (0)
Gene Organization and Regulation (2020) (0)
HSV-Cellular Protein Interactions. (1998) (0)
Students' dilemma (1998) (0)
A purified human autoantibody requires nucleosomes for binding to dsDNA (2005) (0)
Chapter 10 – Conclusions and Future Prospects (2004) (0)
Cell lines of the proliferation of mutant herpes virus (1999) (0)
Lupus and Heat Shock Proteins (2020) (0)
SLE and Antiphospholipid Syndrome [223–231] 223. Acid Disruption Biacore Analysis of Antibodies Against Rituximab in SLE Patients (2010) (0)
ANTI-SERINE PROTEASE ANTIBODIES ARE DISTINGUISHABLE FROM ANTIPHOSPHOLIPID ANTIBODIES IN PATIENTS WITH ANTIPHOSPHOLIPID SYNDROME (2010) (0)
Gene Control and Cellular Signaling Pathways (2020) (0)
PARK6 Linked Parkinson's Disease Is Caused by Mutations in a Mitochondrial Protein Kinase (2004) (0)
374A ABSTRACTS-Myocardial Ischemia and Infarction (2016) (0)
Post-transcriptional processes. (2018) (0)
PINK1 is necessary for long term survival and mitochondrial function in primary human dopaminergic neurons (2009) (0)
Transcription factors - Preface (1996) (0)
Structure of Chromatin (2018) (0)
Viral vectors for treating diseases of the nervous system (2003) (0)
Stress Proteins (1999) (0)
Eukaryotic gene expression cassette and their uses (1998) (0)
PCR in situ Hybridization: Protocols and Applications G. J. Nuovo. Raven Press, New York (1993). 276 pp. ISBN 0–88167–940–2 (1993) (0)
A HUMAN-IGM ANTIMYELOPEROXIDASE ANTIBODY SHOWS EVIDENCE FOR ANTIGEN SELECTION (1993) (0)
Demonstrated Communications (1999) (0)
SUBLETHAL THERMAL AND ISCHEMIC STRESSES INDUCE STRESS PROTEINS AND INCREASE RESISTANCE TO SUBSEQUENT INFARCTION (1993) (0)
Cultured endothelial cells produce microparticles when stimulated with human polyclonal and monoclonal IgG antiphospholipid antibodies (2008) (0)
Sterol Response Element (2002) (0)
Inhibition of histone H2B gene transcription and of cellular growth by a truncated viral trans-activator protein (1990) (0)
Diagnostic value of CK-MB versus cardiac troponin I in the detection of myocardial injury after cardiac surgery (2002) (0)
Investigation of PINK1 dysfunction in Parkinson's disease (2006) (0)
Arginine residues are important in determining the ability of human monoclonal antiphospholipid antibodies to bind clinically relevant antigens in the pathogenesis of the antiphospholipid syndrome (2006) (0)
Conclusions and Future Prospects (2020) (0)
Green tea inhibits Stat-1 activation and reduces apoptosis in cardiac myocytes exposed to ischemia/reperfusion injury (2003) (0)
Antiphospholipid Antibody on Its In Vivo Sequence Changes in a Human Monoclonal Thrombin Binding Predicts the Effects of (0)
Sequence motifs in human monoclonal antiphospholipid antibodies have differential effects on the in vitro production of endothelial microparticles that are not always predicted by their binding properties (2008) (0)

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