Donald Talbot Downing
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Philosophy Biology
Donald Talbot Downing's Degrees
- Doctorate Medicine University of California, San Francisco
- PhD Biochemistry University of California, San Francisco
Why Is Donald Talbot Downing Influential?
(Suggest an Edit or Addition)Donald Talbot Downing's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Prolonged remissions of cystic and conglobate acne with 13-cis-retinoic acid. (1979) (497)
- Presence of intact intercellular lipid lamellae in the upper layers of the stratum corneum. (1987) (354)
- Evidence that the corneocyte has a chemically bound lipid envelope. (1987) (341)
- Ceramides of pig epidermis: structure determination. (1983) (340)
- Molecular models of the intercellular lipid lamellae in mammalian stratum corneum. (1989) (337)
- The composition of the ceramides from human stratum corneum and from comedones. (1985) (337)
- Lipid and protein structures in the permeability barrier of mammalian epidermis. (1992) (297)
- Age-related changes in sebaceous gland activity. (1979) (289)
- Anatomical variation in the amount and composition of human skin surface lipid. (1970) (278)
- Photodensitometry in the thin-layer chromatographic analysis of neutral lipids. (1968) (265)
- 6-Hydroxy-4-sphingenine in human epidermal ceramides. (1994) (262)
- Essential fatty acids and acne. (1986) (247)
- Glycolipids in mammalian epidermis: structure and function in the water barrier. (1982) (242)
- Composition and morphology of epidermal cyst lipids. (1987) (220)
- Control of free fatty acids in human surface lipids by Corynebacterium acnes. (1971) (220)
- Covalently bound lipids of human stratum corneum. (1989) (200)
- Lipid organization in pig stratum corneum. (1995) (195)
- Chemical composition of human skin surface lipids from birth to puberty. (1970) (170)
- Preparation of liposomes from stratum corneum lipids. (1986) (167)
- Covalently bound ω-hydroxyacylsphingosine in the stratum corneum (1987) (167)
- Acylglucosylceramides of pig epidermis: structure determination. (1983) (159)
- Variability in the chemical composition of human skin surface lipids. (1969) (153)
- Enzyme inhibition by acetylenic compounds. (1970) (150)
- Sphingolipids of the stratum corneum and lamellar granules of fetal rat epidermis. (1984) (148)
- Effect of essential fatty acid deficiency on the epidermal sphingolipids of the rat. (1983) (147)
- Skin lipids: an update. (1987) (142)
- The role of the corneocyte lipid envelopes in cohesion of the stratum corneum. (1989) (141)
- X-ray diffraction analysis of isolated skin lipids: reconstitution of intercellular lipid domains. (1996) (137)
- Inhibition of prostaglandin biosynthesis by eicosa-5,8,11,14-tetraynoic acid. (1970) (130)
- Synthesis and Composition of Surface Lipids of Human Skin (1974) (127)
- Age-related changes in sebaceous wax ester secretion rates in men and women. (1985) (127)
- Essential fatty acids and epidermal integrity. (1987) (119)
- A new 6-hydroxy-4-sphingenine-containing ceramide in human skin. (1999) (115)
- Sebaceous gland activity and serum dehydroepiandrosterone sulfate levels in boys and girls. (1992) (113)
- PYRROLIZIDINE ALKALOIDS AS ALKYLATING AND ANTIMITOTIC AGENTS * (1969) (108)
- The effect of marked inhibition of sebum production with 13cis-retinoic acid on skin surface lipid composition. (1980) (107)
- Structural studies on ceramides as lithiated adducts by low energy collisional-activated dissociation tandem mass spectrometry with electrospray ionization (2002) (103)
- Sustainable rates of sebum secretion in acne patients and matched normal control subjects. (1983) (100)
- The role of lipids in the epidermal barrier to water diffusion. (1970) (99)
- Lipid composition of cohesive and desquamated corneocytes from mouse ear skin. (1986) (97)
- Amyloid fibrils may be assembled from beta-helical protofibrils. (1998) (97)
- Sebaceous gland response in man to prolonged total caloric deprivation. (1970) (96)
- Linoleate-rich acylglucosylceramides of pig epidermis: structure determination by proton magnetic resonance. (1985) (96)
- Effects of essential fatty acid deficiency on epidermal O-acylsphingolipids and transepidermal water loss in young pigs. (1987) (81)
- Human stratum corneum polar lipids and desquamation (2004) (81)
- Dilutional effect of increased sebaceous gland activity on the proportion of linoleic acid in sebaceous wax esters and in epidermal acylceramides. (1986) (80)
- Chemistry and function of mammalian sebaceous lipids. (1991) (76)
- Lipids are covalently attached to rigid corneocyte protein envelopes existing predominantly as beta-sheets: a solid-state nuclear magnetic resonance study. (1995) (73)
- Integral lipids of mammalian hair. (1989) (73)
- Variation in sebum fatty acid composition among adult humans. (1984) (71)
- Integral lipids of human hair (1988) (71)
- Preparation of model membranes for skin permeability studies using stratum corneum lipids. (1989) (70)
- Interaction between corneocytes and stratum corneum lipid liposomes in vitro. (1990) (69)
- Free sphingosine in human epidermis. (1990) (67)
- Lipids of chicken epidermis. (1986) (64)
- Skin surface lipid composition, acne, pubertal development, and urinary excretion of testosterone and 17-ketosteroids in children. (1977) (64)
- Lamellar granule extrusion and stratum corneum intercellular lamellae in murine keratinocyte cultures. (1988) (64)
- Octadecadienoic acids in the skin surface lipids of acne patients and normal subjects. (1976) (63)
- Stratum corneum lipid liposomes: calcium-induced transformation into lamellar sheets. (1987) (61)
- The role of the aerobic microflora in the genesis of fatty acids in human surface lipids. (1970) (60)
- Correction for deviation from the Lambert-Beer law in the quantitation of thin-layer chromatograms by photodensitometry (1980) (60)
- Ceramidase activity in porcine epidermis (1990) (59)
- The time course of lipid biosynthesis in pig epidermis. (1988) (59)
- Fatty acids of acylceramides from comedones and from the skin surface of acne patients and control subjects. (1988) (56)
- Partition of sodium dodecyl sulfate into stratum corneum lipid liposomes (2005) (54)
- Lipids of epidermis and keratinized and non-keratinized oral epithelia. (1986) (54)
- Influence of Pityrosporum species in the generation of free fatty acids in human surface lipids. (1972) (54)
- Free sphingosines in porcine epidermis. (1989) (52)
- The lipid composition of porcine epidermis and oral epithelium. (1986) (52)
- Metabolism of linoleic acid in porcine epidermis. (1990) (52)
- The effect of accumulated lipids on measurements of sebum secretion in human skin. (1982) (51)
- Measurement of sebum secretion rates in young children. (1985) (50)
- Deuterium NMR investigation of polymorphism in stratum corneum lipids. (1991) (50)
- Changes in the relative amounts of endogenous and exogenous fatty acids in sebaceous lipids during early adolescence. (1989) (49)
- Changes in skin surface lipid composition induced by severe caloric restriction in man. (1972) (48)
- The sebaceous glands: twenty-five years of progress. (1976) (45)
- Free sphingosines of human skin include 6-hydroxysphingosine and unusually long-chain dihydrosphingosines. (1995) (45)
- Variability in the fatty acid composition of wax esters from vernix caseosa and its possible relation to sebaceous gland activity. (1982) (44)
- Measurement of the time between synthesis and surface excretion of sebaceous lipids in sheep and man. (1975) (44)
- Structural requirements of acetylenic fatty acids for inhibition of soybean lipoxygenase and prostaglandin synthetase. (1972) (43)
- Composition of cerumen lipids. (1990) (42)
- Murine keratinocyte cultures grown at the air/medium interface synthesize stratum corneum lipids and "recycle" linoleate during differentiation. (1989) (42)
- Variation of skin surface lipid composition among mammals (1981) (41)
- Analysis of aqueous solutions of organic acids by pyrolysis of their tetramethylammonium salts in the gas chromatograph (1967) (41)
- Lipid composition of cultured murine keratinocytes. (1986) (40)
- The ω-hydroxyceramides of pig epidermis are attached to corneocytes solely through ω-hydroxyl groups (2001) (40)
- Covalent attachment of omega-hydroxyacid derivatives to epidermal macromolecules: a preliminary characterization. (1986) (40)
- The time course of lipid formation in human sebaceous glands. (1977) (39)
- Effect of oral 13-cis-retinoic acid at three dose levels on sustainable rates of sebum secretion and on acne. (1983) (39)
- The origin of alkanes found in human skin surface lipids. (1989) (38)
- Suppression of sebum secretion with 13-cis-retinoic acid: effect on individual skin surface lipids and implications for their anatomic origin. (1984) (37)
- Possible genetic control of the proportions of branched-chain fatty acids in human sebaceous wax esters. (1986) (37)
- Double bond positions in the unsaturated fatty acids of vernix caseosa. (1968) (36)
- Estimation of sebum production rates in man by measurement of the squalene content of skin biopsies. (1981) (36)
- Glucosylsterol and acylglucosylsterol of snake epidermis: structure determination. (1987) (34)
- Acylglucosylceramide causes flattening and stacking of liposomes. An analogy for assembly of the epidermal permeability barrier. (1984) (34)
- Effect of cyproterone acetate-ethinyl estradiol treatment on the proportions of linoleic and sebaleic acids in various skin surface lipid classes (2004) (34)
- The nonpolar lipids of pig epidermis. (1988) (34)
- Metabolism of topically applied fatty acid methyl esters in BALB/C mouse epidermis. (1990) (33)
- Methylation of fatty acids by pyrolysis of their tetramethylammonium salts in the gas chromatograph. (1968) (33)
- Changes in sebum secretion and the sebaceous gland. (1986) (33)
- Covalently bound omega-hydroxyacylsphingosine in the stratum corneum. (1987) (32)
- Fusion patterns of liposomes formed from stratum corneum lipids. (1988) (31)
- A survey of polar and nonpolar lipids extracted from snake skin. (1985) (31)
- The polar lipids from keratinized tissues of some vertebrates. (1982) (30)
- Quantitative assessment of the persistent antimitotic effect of certain hepatotoxic pyrrolizidine alkaloids on rat liver. (1968) (30)
- Circular dichroism of model peptides emulating the amphipathic alpha-helical regions of intermediate filaments. (1997) (29)
- Proportions of various straight and branched fatty acid chain types in the sebaceous wax esters of young children. (1985) (28)
- On the mechanism of sebaceous secretion (2004) (27)
- The role of sebum and epidermal lipids in the cosmetic properties of skin (1986) (27)
- The fatty acids of human sebaceous gland phosphatidylcholine. (1978) (27)
- Sphingolipid metabolism in organotypic mouse keratinocyte cultures. (1990) (26)
- β-Helical Fibrils from a Model Peptide (1997) (26)
- Crystalline Regions of Bombyx mori Silk Fibroin May Exhibit -Turn and -Helix Conformations (1999) (26)
- Cholesteryl sulfate: the major polar lipid of horse hoof. (1984) (24)
- The effect of 13-cis-retinoic acid on sebaceous glands. (1987) (24)
- Identification of a fatty acid in human skin surface lipids apparently associated with acne vulgaris. (1973) (24)
- Sclerosing lipogranuloma of the male genitalia containing vitamin E: a comparison with classical "paraffinoma". (1983) (24)
- A survey of polar and non-polar lipids of mouse organs. (1985) (23)
- Glucosylceramides of pig epidermis: structure determination. (1983) (23)
- Lipolysis by human skin surface debris in organic solvents. (1970) (23)
- Changes in sebum secretion and the sebaceous gland. (1989) (22)
- Lamellar Structures Formed by Stratum Corneum Lipids in Vitro: A Deuterium Nuclear Magnetic Resonance (NMR) Study (1992) (22)
- Molecular modelling indicates that the pathological conformations of prion proteins might be beta-helical. (1999) (22)
- Cholesterol sulfate protects Candida albicans from inhibition by sphingosine in vitro. (1996) (22)
- Effect of epidermal acylglucosylceramides and acylceramides on the morphology of liposomes prepared from stratum corneum lipids. (1988) (21)
- Fibril formation by amyloid-beta proteins may involve beta-helical protofibrils. (1999) (21)
- Linoleate content of epidermal acylglucosylceramide in newborn, growing and mature mice. (1986) (21)
- Trans-unsaturated fatty acids in human skin surface lipids. (1976) (20)
- The omega-hydroxyceramides of pig epidermis are attached to corneocytes solely through omega-hydroxyl groups. (2001) (20)
- Skin lipids of the Florida indigo snake (2006) (20)
- Skin surface lipids of the guinea pig. (1976) (20)
- The effect of lipids on transepidermal water permeation in snakes. (1985) (19)
- Skin surface lipids of the dog (1977) (18)
- A Mixture of α-Helical and 310-Helical Conformations for Involucrin in the Human Epidermal Corneocyte Envelope Provides a Scaffold for the Attachment of Both Lipids and Proteins* (1999) (17)
- β-Glucosidase activity in porcine epidermis (1989) (17)
- Differential inhibition of prostaglandin synthetase and soybean lipoxygenase. (1972) (17)
- Unusual cholesterol esters in the sebum of young children. (1990) (17)
- Skin surface lipids of the cow. (1982) (16)
- Interaction between sphingosine and cholesteryl sulfate in epidermal lipids. (1993) (16)
- Isolation of corneocyte envelopes from porcine epidermis (2004) (16)
- Membrane structural alterations in murine stratum corneum: relationship to the localization of polar lipids and phospholipases. (1989) (15)
- omega-Hydroxyacid derivatives in the epidermis of several mammalian species. (1989) (14)
- Relationship between sebum secretion rates and the concentration of linoleate in sebum and epidermal lipids (1985) (13)
- Skin surface lipids of the horse (1980) (13)
- Skin lipids and acne. (1975) (13)
- A survey of polar and nonpolar lipids from epidermis and epidermal appendages of the chicken (Gallus domesticus). (1986) (12)
- Variation in skin surface lipid composition among the Equidae. (1983) (11)
- Rapid determination of double-bond positions in monoenoic fatty acids by periodate-permanganate oxidation (2006) (11)
- Polar lipid composition of mammalian hair. (1987) (10)
- Preen Gland and Scent Gland Lipids (1986) (10)
- Sebum Secretion and Sebaceous Lipids (1983) (10)
- Nutritional influences of pellagra on sebum composition (1977) (10)
- Acne: perspectives. (1974) (10)
- Separation of wax esters from steryl esters by chromatography on magnesium hydroxide (1981) (10)
- Lipids : their role in epidermal structure and function (1991) (10)
- Freeze-fracture electron microscopic and osmotic water permeability studies of epidermal lipid liposomes derived from stratum corneum lipids of porcine epidermis. (1993) (10)
- The time-course of lipid biosynthesis in horse skin. (1985) (9)
- Chemical cross‐linking between lysine groups in vimentin oligomers is dependent on local peptide conformations (1996) (9)
- BRANCHED-CHAIN FATTY ACIDS IN LIPIDS OF THE NEWLY BORN LAMB. (1964) (9)
- Effects of Na2SO4 on hydrophobic and electrostatic interactions between amphipathic α-helices (2001) (8)
- Evaluation of a method for measuring the sustainable rate of sebaceous wax ester secretion (2004) (8)
- Molecular modeling indicates that homodimers form the basis for intermediate filament assembly from human and mouse epidermal keratins (1995) (7)
- Beta-helical fibrils from a model peptide. (1997) (7)
- Comparison of the hydroxyacids from the epidermis and from the sebaceous glands of the horse. (1983) (7)
- Occurrence of squalene in skin surface lipids of the otter, the beaver and the kinkajou (1980) (7)
- Measurement of the time between biosynthesis and surface excretion of sebaceous lipids in the horse. (1985) (6)
- Skin surface lipids of the mole Scalopus aquaticus. (1987) (6)
- Analysis of soluble proteins in comedones. (1977) (6)
- Beta-glucosidase activity in porcine epidermis. (1989) (5)
- Linoleate-rich O-acylsphingolipids of mammalian epidermis: Structures and effects of essential fatty acid deficiency (1986) (5)
- Molecular modeling of vimentin filament assembly (1996) (5)
- Hydroxyacid derivatives in human epidermis (1988) (5)
- Comparison of acetate and glucose incorporation into rat and horse skin lipids. (1985) (4)
- Structures of the dienoic lactones of horse sebum. (1984) (3)
- In vivo studies of cutaneous lipid biosynthesis. (1992) (3)
- Skin lipids. (1983) (3)
- Uropygiols: confirmation of structure by proton magnetic resonance. (1985) (3)
- Stabilization of amphipathic α‐helical and β‐helical conformations in synthetic peptides in the presence and absence of ionic interactions (2009) (3)
- Skin surface lipids of the mink. (1986) (2)
- The role of skin lipids in acne. (1976) (2)
- The time course of sebum secretion in the guinea-pig. (1985) (2)
- Molecular modeling of keratin intermediate filament assembly driven by aqueous surface tension (1994) (1)
- Skin lipids. (1992) (1)
- Reply. Alkanes: Endogenous or Exogenous? (1990) (1)
- Effects of Na2SO4 on hydrophobic and electrostatic interactions between amphipathic alpha-helices. (2001) (1)
- Stabilization of amphipathic alpha-helical and beta-helical conformations in synthetic peptides in the presence and absence of ionic interactions. (1998) (1)
- Very long chain fatty acids in childrens sebum (1990) (0)
- Morphologic and biochemical lipid markers of terminal epidermal differentiation in cultured keratinocytes (1988) (0)
- Surface lipid composition in children with protein-calorie malnutrition. (1978) (0)
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