Dafna Bar‐sagi
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Biochemistry
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Biology
Dafna Bar‐sagi's Degrees
- PhD Biochemistry Weizmann Institute of Science
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(Suggest an Edit or Addition)Dafna Bar‐sagi's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. (2000) (1798)
- The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling (1992) (1546)
- RAS oncogenes: weaving a tumorigenic web (2011) (1492)
- Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells (2013) (1192)
- Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts. (1993) (1107)
- Nucleolar Arf sequesters Mdm2 and activates p53 (1999) (1000)
- Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling (1993) (897)
- A Lipid-Anchored Grb2-Binding Protein That Links FGF-Receptor Activation to the Ras/MAPK Signaling Pathway (1997) (876)
- Ras and Rho GTPases A Family Reunion (2000) (840)
- Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis. (2004) (806)
- Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. (1993) (734)
- The structural basis of the activation of Ras by Sos (1998) (728)
- Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation (1985) (702)
- Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization (1997) (699)
- Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by ras proteins. (1986) (678)
- Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia. (2012) (565)
- Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome (2006) (561)
- Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. (2015) (544)
- Redox-dependent downregulation of Rho by Rac (2003) (540)
- Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras (1993) (516)
- The Bax Subfamily of Bcl2-Related Proteins Is Essential for Apoptotic Signal Transduction by c-Jun NH2-Terminal Kinase (2002) (514)
- Regulating the regulator: post-translational modification of RAS (2011) (486)
- Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos. (1998) (475)
- Direct coupling of the cell cycle and cell death machinery by E2F (2002) (458)
- EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration. (2018) (407)
- Inhibition of ras-induced proliferation and cellular transformation by p16INK4 (1995) (406)
- Structural Evidence for Feedback Activation by Ras·GTP of the Ras-Specific Nucleotide Exchange Factor SOS (2003) (397)
- Stimulation of Membrane Ruffling and MAP Kinase Activation by Distinct Effectors of RAS (1996) (396)
- Modulation of signalling by Sprouty: a developing story (2004) (366)
- G-protein βγ-subunits activate the cardiac muscarinic K+-channel via phospholipase A2 (1989) (364)
- SH3 domains direct cellular localization of signaling molecules (1993) (308)
- Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos (2007) (282)
- Structural Analysis of Autoinhibition in the Ras Activator Son of Sevenless (2004) (276)
- RAC Regulation of Actin Polymerization and Proliferation by a Pathway Distinct from Jun Kinase (1996) (271)
- Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling. (2001) (268)
- In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha. (2009) (266)
- MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells (2012) (240)
- Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors (2016) (230)
- IL35-Producing B Cells Promote the Development of Pancreatic Neoplasia. (2016) (229)
- Crystal Structure of the Dbl and Pleckstrin Homology Domains from the Human Son of Sevenless Protein (1998) (228)
- An Orthosteric Inhibitor of the Ras-Sos Interaction (2011) (228)
- Inhibition of Ras-induced DNA synthesis by expression of the phosphatase MKP-1. (1994) (227)
- Crosstalk between Regulatory T Cells and Tumor-Associated Dendritic Cells Negates Anti-tumor Immunity in Pancreatic Cancer (2017) (227)
- An SH3 binding region in the epithelial Na+ channel (alpha rENaC) mediates its localization at the apical membrane. (1994) (225)
- γδ T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell Activation (2016) (219)
- Membrane-dependent signal integration by the Ras activator Son of sevenless (2008) (217)
- The Ras superfamily of GTPases 1 (1996) (213)
- Differential modification of Ras proteins by ubiquitination. (2006) (206)
- A Rac1 Effector Site Controlling Mitogenesis through Superoxide Production* (1998) (197)
- Identification of a novel Rac1‐interacting protein involved in membrane ruffling. (1996) (189)
- Suppression of Ras-Induced Apoptosis by the Rac GTPase (1999) (180)
- Differential Activation of the Rac Pathway by Ha-Ras and K-Ras* (2001) (170)
- Ras effectors and their role in mitogenesis and oncogenesis (1997) (168)
- Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2 (1996) (166)
- Rac1 mediates STAT3 activation by autocrine IL-6 (2001) (160)
- The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins (2002) (158)
- The role of the PH domain in the signal‐dependent membrane targeting of Sos (1997) (157)
- Role of boundary conditions in an experimental model of epithelial wound healing. (2006) (155)
- Ras/MAPK signaling from endomembranes (2009) (146)
- Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors (2007) (145)
- The structural basis for the transition from Ras-GTP to Ras-GDP (2002) (145)
- hSpry2 Is Targeted to the Ubiquitin-Dependent Proteasome Pathway by c-Cbl (2003) (144)
- Suppression of Ras-stimulated transformation by the JNK signal transduction pathway. (2003) (139)
- VEGF exerts an angiogenesis-independent function in cancer cells to promote their malignant progression. (2012) (137)
- Determining the macropinocytic index of cells through a quantitative image-based assay (2014) (135)
- A Ras-induced conformational switch in the Ras activator Son of sevenless (2006) (130)
- Sos-mediated cross activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis (2012) (130)
- Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response. (2014) (129)
- Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells. (2010) (126)
- Tumor Cell-Derived IL-1β Promotes Desmoplasia and Immune Suppression in Pancreatic Cancer. (2020) (126)
- Regulation of Ras Signaling Dynamics by Sos-Mediated Positive Feedback (2006) (114)
- Structure-based Mutagenesis Reveals Distinct Functions for Ras Switch 1 and Switch 2 in Sos-catalyzed Guanine Nucleotide Exchange* (2001) (113)
- A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen. (2006) (106)
- EZH2 couples pancreatic regeneration to neoplastic progression. (2012) (105)
- Feedback Regulation of Ras Signaling by Rabex-5-Mediated Ubiquitination (2010) (104)
- Mutant KRAS Enhances Tumor Cell Fitness by Upregulating Stress Granules (2016) (103)
- Macropinocytosis of Nab-paclitaxel Drives Macrophage Activation in Pancreatic Cancer (2017) (103)
- Activation of Ras and other signaling pathways by receptor tyrosine kinases. (1994) (103)
- Distinct populations of metastases‐enabling myeloid cells expand in the liver of mice harboring invasive and preinvasive intra‐abdominal tumor (2010) (99)
- The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways (2008) (99)
- Regulation of Sos Activity by Intramolecular Interactions (1998) (97)
- Kinase Suppressor of Ras Inhibits the Activation of Extracellular Ligand-regulated (ERK) Mitogen-activated Protein (MAP) Kinase by Growth Factors, Activated Ras, and Ras Effectors* (1998) (96)
- Regulation of RAS oncogenicity by acetylation (2012) (95)
- Prevention of Radiation-Induced Oral Cavity Mucositis by Plasmid/Liposome Delivery of the Human Manganese Superoxide Dismutase (SOD2) Transgene (2003) (93)
- A Ras by Any Other Name (2001) (93)
- Oncogenic K-ras Drives Cell Cycle Progression and Phenotypic Conversion of Primary Pancreatic Duct Epithelial Cells (2004) (92)
- Pulmonary irradiation-induced expression of VCAM-I and ICAM-I is decreased by manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy. (2002) (86)
- Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless (2010) (84)
- Co-capping of ras proteins with surface immunoglobulins in B lymphocytes (1990) (82)
- Design, synthesis, and biological evaluation of new-generation taxoids. (2008) (82)
- Regulation of Sprouty Stability by Mnk1-Dependent Phosphorylation (2006) (79)
- The Two Hats of SOS (2002) (78)
- Plasma membrane v-ATPase controls oncogenic Ras-induced macropinocytosis (2019) (77)
- Chronic pancreatitis, pancreatic adenocarcinoma and the black box in-between (2005) (76)
- Degranulation of individual mast cells in response to Ca2+ and guanine nucleotides: an all-or-none event (1993) (76)
- Structure of the G60A Mutant of Ras (2005) (75)
- Honokiol Suppresses Survival Signals Mediated by Ras-Dependent Phospholipase D Activity in Human Cancer Cells (2008) (75)
- E-Cadherin-Mediated Cell Coupling Is Required for Apoptotic Cell Extrusion (2014) (75)
- Pathophysiology of Acute Pancreatitis (2009) (75)
- Fibronectin growth factor-binding domains are required for fibroblast survival. (2011) (72)
- Spatial Regulation of EGFR Signaling by Sprouty2 (2007) (72)
- Selective alanine transporter utilization creates a targetable metabolic niche in pancreatic cancer. (2020) (67)
- Computational docking and solution x-ray scattering predict a membrane-interacting role for the histone domain of the Ras activator son of sevenless. (2005) (64)
- The Solution Structure of the Pleckstrin Homology Domain of Human SOS1 (1997) (58)
- Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas. (2009) (56)
- Kras and Tumor Immunity: Friend or Foe? (2018) (54)
- Cell phenotype specific kinetics of expression of intratracheally injected manganese superoxide dismutase–plasmid/liposomes (MnSOD–PL) during lung radioprotective gene therapy (2003) (48)
- Effect of tunicamycin, an inhibitor of protein glycosylation, on the biological properties of acetylcholine receptor in cultured muscle cells. (1983) (47)
- Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression. (2013) (46)
- Allosteric gating of Son of sevenless activity by the histone domain (2010) (46)
- The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers. (2019) (45)
- Signaling endosomes: seeing is believing. (2010) (45)
- A bright future for KRAS inhibitors (2020) (45)
- One-way membrane trafficking of SOS in receptor-triggered Ras activation (2016) (44)
- The Pleckstrin Homology (PH) Domain-Interacting Protein Couples the Insulin Receptor Substrate 1 PH Domain to Insulin Signaling Pathways Leading to Mitogenesis and GLUT4 Translocation (2002) (43)
- BTK SIGNALING DRIVES CD1dhiCD5+ REGULATORY B CELL DIFFERENTIATION TO PROMOTE PANCREATIC CARCINOGENESIS (2018) (43)
- Pancreatic duct epithelial cell isolation and cultivation in two-dimensional and three-dimensional culture systems. (2006) (42)
- The Sos (Son of sevenless) protein (1994) (41)
- Molecular Pathways: Targeting the Dependence of Mutant RAS Cancers on the DNA Damage Response (2014) (40)
- Trifluoperazine, a calmodulin antagonist, inhibits muscle cell fusion (1983) (40)
- Differential Interactions of Human Sos1 and Sos2 with Grb2 (*) (1995) (39)
- G-protein beta gamma-subunits activate the cardiac muscarinic K+-channel via phospholipase A2. (1989) (37)
- Induction of the Cellular E2F-1 Promoter by the Adenovirus E4-6/7 Protein (2000) (37)
- Tandem histone folds in the structure of the N-terminal segment of the ras activator Son of Sevenless. (2003) (37)
- An orthosteric inhibitor of the RAS-SOS interaction. (2013) (35)
- Anoxia induces phospholipase A2 activation in rabbit renal proximal tubules. (1992) (34)
- ras proteins: biological effects and biochemical targets (review). (1989) (34)
- Localization of phospholipase A2 in normal and ras-transformed cells (1988) (33)
- Introduction of unlabeled proteins into living cells by electroporation and isolation of viable protein-loaded cells using dextran-fluorescein isothiocyanate as a marker for protein uptake. (1991) (32)
- Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer. (2022) (31)
- Characterization of a Ras mutant with identical GDP- and GTP-bound structures . (2009) (29)
- Stimulation of exocytotic degranulation by microinjection of the ras oncogene protein into rat mast cells. (1988) (29)
- MyD 88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th 2 cells (2012) (28)
- Crosslinking of the surface immunoglobulin receptor in B lymphocytes induces a redistribution of neurofibromin but not p120-GAP. (1994) (28)
- SCH 51344-induced reversal of RAS-transformation is accompanied by the specific inhibition of the RAS and RAC-dependent cell morphology pathway (1997) (28)
- Ras and Rac as activators of reactive oxygen species (ROS). (2002) (28)
- CHMP6 and VPS4A mediate recycling of Ras to the plasma membrane to promote growth factor signaling (2011) (27)
- Inhibition of cell surface ruffling and fluid‐phase pinocytosis by microinjection of anti‐ras antibodies into living cells (1987) (27)
- Ras Oncogene and Inflammation: Partners in Crime (2005) (24)
- Gain-of-function p53R172H mutation drives accumulation of neutrophils in pancreatic tumors, promoting resistance to immunotherapy. (2021) (24)
- Tunicamycin inhibits the expression of surface Na+ channels in cultured muscle cells (1983) (24)
- Overexpression of mouse D-type cyclins accelerates G 1 phase in (2007) (22)
- EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion (2021) (20)
- The G protein–coupled receptor GPR31 promotes membrane association of KRAS (2017) (20)
- Insulin-induced dissociation of Sos from Grb2 does not contribute to the down regulation of Ras activation. (1996) (19)
- Macropinocytosis as a Key Determinant of Peptidomimetic Uptake in Cancer Cells. (2020) (18)
- Autoinhibition of Sos by intramolecular interactions. (2002) (17)
- ATDC is required for the initiation of KRAS-induced pancreatic tumorigenesis (2019) (16)
- Mapping Cellular Routes of Ras: A Ubiquitin Trail (2006) (16)
- Differential expression of sodium channel activities during the development of chick skeletal muscle cells in culture (1983) (15)
- Perturbation of cytoskeleton dynamics by the opposing effects of Rac1 and Rac1b (2010) (15)
- Pre-neoplastic pancreas cells enter a partially mesenchymal state following transient TGF-β exposure (2018) (15)
- Covalent Targeting of Ras G12C by Rationally Designed Peptidomimetics. (2020) (15)
- Mammalian cell microinjection assay. (1995) (14)
- Exploiting cancer's drinking problem: regulation and therapeutic potential of macropinocytosis. (2021) (13)
- Negative modulation of sodium channels in cultured chick muscle cells by the channel activator batrachotoxin. (1985) (12)
- Metabolic reprogramming of tumor-associated macrophages by collagen turnover promotes fibrosis in pancreatic cancer (2022) (11)
- Effect of H-ras proteins on the activity of polyphosphoinositide phospholipase C in HL60 membranes. (1990) (10)
- Regulation of membrane turnover byras proteins (1987) (10)
- Clinical and therapeutic implications of Sprouty2 feedback dysregulation in BRAF V600E-mutation-positive papillary thyroid cancer. (2013) (10)
- Spry2 expression correlates with BRAF mutation in thyroid cancer. (2010) (10)
- Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia (2021) (9)
- Mechanisms of signal transduction by Ras. (1992) (9)
- Integrated Systems Analysis of the Murine and Human Pancreatic Cancer Glycomes Reveals a Tumor-Promoting Role for ST6GAL1 (2021) (9)
- Histological Image Processing Features Induce a Quantitative Characterization of Chronic Tumor Hypoxia (2016) (8)
- Microdissection and culture of murine pancreatic ductal epithelial cells. (2013) (8)
- High-content, full genome siRNA screen for regulators of oncogenic HRAS-driven macropinocytosis. (2015) (7)
- A novel target for combination immunotherapy in pancreatic cancer: IL-1β mediates immunosuppression in the tumour microenvironment (2021) (7)
- Analysis of Ras:RasGEF interactions by phage display and static multi-angle light scattering. (2005) (7)
- Association of p21ras with cellular polypeptides. (1991) (6)
- Simulating Heterogeneous Tumor Cell Populations (2016) (4)
- Single cell assays for Rac activity. (2000) (4)
- SCH 51344, An Inhibitor of RAS/RAC‐Mediated Cell Morphology Pathway (1999) (4)
- CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer (2023) (3)
- Pancreatic cancer ductal cell of origin drives CD73-dependent generation of immunosuppressive adenosine (2021) (3)
- A phase Ib study combining irinotecan with AZD1775, a selective WEE 1 kinase inhibitor, in RAS/RAF mutated metastatic colorectal cancer patients who progressed on first line therapy. (2017) (3)
- Antitumor activity and immune reponse in CD40 immunotherapy with gemcitabine and nab-paclitaxel in an orthotopic pancreatic cancer mouse model. (2016) (3)
- Erratum: Membrane-dependent signal integration by the Ras activator Son of sevenless (2008) (3)
- Phospholipase A2: microinjection and cell localization techniques. (1991) (3)
- MACHETE identifies interferon-encompassing chromosome 9p21.3 deletions as mediators of immune evasion and metastasis (2022) (3)
- Raf-1 and squamous cell carcinoma: Rok-ing the boat. (2009) (3)
- The Role of Rac and Rho in Cell Cycle Progression (2010) (2)
- Biochemical and biophysical analyses of Ras modification by ubiquitin. (2008) (2)
- Abstract 3001: Accurins are endocytosed by KRAS-mutant cells via macropinocytosis (2016) (2)
- γδ T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell Activation (2020) (2)
- Abstract 2797: Accumulation of neutrophils in the tumor microenvironment promotes resistance to immunotherapy in pancreatic cancer (2019) (2)
- Escorting Ras (2012) (2)
- [13] Purification of baculovirus-expressed human Sos 1 protein (1995) (2)
- Phospholipase a-2 in Ras-Transformed Cells (1989) (2)
- α2,6-Sialylation is Upregulated in Severe COVID-19 Implicating the Complement Cascade (2022) (1)
- Chromosome 9p21.3 Coordinates Cell Intrinsic and Extrinsic Tumor Suppression (2022) (1)
- Acknowledgment of Guest Editors, 2019 (2019) (1)
- Abstract LB-224: Nab-paclitaxel and agonist CD40 mAb combination therapy induces tumor-associated macrophage polarization switching in pancreatic cancer (2015) (1)
- Bone marrow origin of esophageal stem cells (2001) (1)
- Faculty Opinions recommendation of Live-cell imaging of enzyme-substrate interaction reveals spatial regulation of PTP1B. (2007) (0)
- Purification of baculovirus-expressed human Sos1 protein. (1995) (0)
- α2,6-Sialylation Is Upregulated in Severe COVID-19, Implicating the Complement Cascade (2022) (0)
- Microinjection of Ras Oncogene Proteins and Inhibitory Antibodies Specific for the Ras Oncogene Proteins into Living Normal and Transformed-Cells (1985) (0)
- Ras and the cancer cell: A transforming relationship (2008) (0)
- Abstract PR5: Macropinocytosis as a mechanism of amino acid supply. (2012) (0)
- Abstract PR08: Pulling out all the stops: Exploiting macropinocytosis inhibition for the treatment of pancreatic cancer (2015) (0)
- Faculty Opinions recommendation of Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis. (2003) (0)
- Stress Granules in Pancreatic Cancer: Drug Resistance & Treatment (2017) (0)
- Faculty Opinions recommendation of A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal. (2009) (0)
- Abstract SY24-03: The signaling landscape of oncogenic ras (2010) (0)
- Preclinical immunotherapy studies using an orthotopic pancreatic cancer mouse model. (2015) (0)
- Abstract 3441: A multivalent peptoid conjugate that inhibits therapy-resistant prostate cancer cell proliferation by modulating androgen receptor transcriptional activity (2023) (0)
- Faculty Opinions recommendation of An immunosurveillance mechanism controls cancer cell ploidy. (2012) (0)
- Abstract PR03: Selective sensitization of mutant K-Ras cancer cells to DNA damage based therapies by targeting wild type H- and N-Ras. (2013) (0)
- Faculty Opinions recommendation of Recruitment of actin modifiers to TrkA endosomes governs retrograde NGF signaling and survival. (2011) (0)
- The Biology of K-Ras Signaling Pathways in Pancreatic Cancer (2013) (0)
- ReviewRas and Rho GTPases : A Family Reunion Rap 1 , is required to define the position of the new bud (2000) (0)
- HYPERLIPIDEMIA CAUSES PANCREATIC INFLAMMATION AND DUCTAL PROLIFERATION IN APOLIPOPROTEIN E DEFICIENT MICE (2007) (0)
- Plasma membrane V-ATPase controls oncogenic RAS-induced macropinocytosis (2019) (0)
- Abstract PR-005: Tumor intrinsic p53 mutation drives accumulation of neutrophils in the pancreatic tumor microenvironment promoting resistance to immunotherapy (2020) (0)
- Acknowledgment of Reviewers for 2011 (2012) (0)
- Crystal structure of the DH-PH-cat module of Son of Sevenless (SOS) (2004) (0)
- Acknowledgment of Reviewers, 2019 (2019) (0)
- Crystal Structure of catalytic domain of Son of sevenless (Rem-Cdc25) in the absence of Ras (2006) (0)
- Abstract PR12: Bringing the outside in: Macropinocytosis and cancer therapeutics (2013) (0)
- Faculty Opinions recommendation of Clathrin-independent endocytosis of ubiquitinated cargos. (2005) (0)
- Tumor-Intrinsic Gain-of-Function p53 R172H Mutation Drives Accumulation of Neutrophils in the Pancreatic Tumor Microenvironment that Promotes Resistance to Immunotherapy (2020) (0)
- of epithelial wound healing Role of boundary conditions in an experimental model (2006) (0)
- Abstract IA21: Ras oncogene in cancer pathogenesis and therapy (2016) (0)
- Crystal Structure of RasA59G in the GDP-bound Form (2002) (0)
- Abstract IA24: Oncogenic Ras-dependent tumor cell vulnerabilities (2020) (0)
- Crystal Structure of a ternary Ras:SOS:Ras*GDP complex (2004) (0)
- Abstract IA002: Contextual determinants of pancreatic tumorigenesis (2022) (0)
- PROLONGED EXPOSURE TO HIGH FAT DIET AND HYPERLIPIDEMIA IN MICE EXACERBATES ACUTE PANCREATITIS (2008) (0)
- Generation of a mouse model of hereditary pancreatitis: Analysis of a predisposing condition for pancreatic adenocarcinoma (2004) (0)
- Faculty Opinions recommendation of Differential targeting of Gbetagamma-subunit signaling with small molecules. (2006) (0)
- MECHANISMS & MODELS OF CANCER (2010) (0)
- Trifluoperazine, a Calmodulin Inhibits Muscle Cell Fusion Antagonist, (2002) (0)
- Faculty Opinions recommendation of Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. (2002) (0)
- Abstract PR22: Collagen scavenging alters macrophage phenotype in pancreatic cancer (2020) (0)
- Abstract 6142: Gain-of-function p53R172H mutation drives accumulation of neutrophils in the pancreatic tumor microenvironment promoting resistance to immunotherapy (2022) (0)
- Table of Contents (1994) (0)
- Tyrosine kinases to Ras (1993) (0)
- silenced in mouse and human B-cell lymphomas Expression of sprouty2 inhibits B-cell proliferation and is epigenetically (2009) (0)
- Abstract B46: Stabilized helices targeting the RAS-SOS interaction as inhibitors of RAS-dependent cancer cell growth (2014) (0)
- Abstract A102: Dendritic cells contribute to pancreatic fibroinflammatory disease and the transition to neoplasia. (2012) (0)
- Abstract A100: Crosstalk between regulatory T cells and tumor-associated dendritic cells controls antitumor immunity in pancreatic cancer (2016) (0)
- Book Review:Guidebook to the Small GTPases. Marino Zerial, Lukas A. Huber (1997) (0)
- Abstract LT005: Tumor-intrinsic gain of function p53R172H mutation drives accumulation of neutrophils in the pancreatic tumor microenvironment that promotes resistance to immunotherapy (2021) (0)
- Faculty Opinions recommendation of Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. (2012) (0)
- Selective sensitization of Ras-mutant (Ras-m) cancer cells to DNA-damaging chemotherapy by Wee1 inhibition with AZD1775. (2015) (0)
- Integrated Systems-Analysis of the Human and Murine Pancreatic Cancer Glycomes Reveal a Tumor Promoting Role for ST6GAL1 (2021) (0)
- Experimentally Phased Structure of Human the Son of Sevenless protein at 4.1 Ang. (2004) (0)
- Abstract PR005: Primary results of PanCAN-SR1, a phase 1b study evaluating Gemcitabine, nab-Paclitaxel, Canakinumab, and Spartalizumab to target IL-1β and PD-1 in metastatic pancreatic cancer with correlative tissue and blood biomarker analysis (2022) (0)
- Acknowledgment of Reviewers 2013 (2013) (0)
- Compartment‐dependent modulation of Ras ubiquitination (2008) (0)
- Exercise-Induced Engagement of the IL-15/IL15Rα axis Promotes Anti-Tumor Immunity (2021) (0)
- Histone‐folds: A novel membrane‐anchoring domain in Son of Sevenless (2009) (0)
- Crystal Structure of the Histone domain of Son of Sevenless (2003) (0)
- Abstract IA21: Immune rewiring of mutant Ras tumors: Mechanisms and translational implications (2023) (0)
- Abstract B62: The role of B regulatory cells in pancreatic cancer (2015) (0)
- Faculty Opinions recommendation of Son of sevenless directly links the Robo receptor to rac activation to control axon repulsion at the midline. (2006) (0)
- Abstract A12: Establishing in vitro and in vivo models of pancreatic ductal adenocarcinoma (PDA) utilizing both acinar and ductal lineages (2015) (0)
- CHAPTER 239 – The Role of Rac and Rho in Cell Cycle Progression (2003) (0)
- P21-Ras Involvement in T-Lymphocyte Activation (1991) (0)
- Faculty Opinions recommendation of A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. (2007) (0)
- Transmembrane signaling protocols (1998) (0)
- Abstract B060: Investigating the role of ERphagy in pancreatic cancer (2022) (0)
- ONCOLOGISTS’ GuIDe TO GeNOMICS (2016) (0)
- Cytoskeletal association of ATP citrate lyase controls the mechanodynamics of macropinocytosis (2022) (0)
- Abstract B39: Regulation and function of IL-1b in immune modulation of pancreatic cancer (2020) (0)
- Faculty Opinions recommendation of A dimerization-dependent mechanism drives RAF catalytic activation. (2009) (0)
- LIST OF POSTERS - RESEARCH DAY - 2006 (2006) (0)
- Faculty Opinions recommendation of Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms. (2003) (0)
- Faculty Opinions recommendation of K-Ras mediates cytokine-induced formation of E-cadherin-based adherens junctions during liver development. (2002) (0)
- Time course of increased manganese superoxide dismutase (MnSOD) biochemical activity and cell types specific expression in lungs of C57BL/6J mice intratracheally injected with MnSOD plasmid/liposome complex (MnSOD-PL) (2002) (0)
- Abstract 5147: Glutamine addiction: Recognizing and harnessing the pathometabolic potential of Ras-mediated macropinocytosis (2012) (0)
- Regulation of HRas signaling by Rabex‐5‐mediated ubiquitination (2009) (0)
- Cell Signalling. Cancer Surveys: Advances and Prospects in Clinical, Epidemiological and Laboratory Oncology, Volume 27.P. J. Parker , T. Pawson (1998) (0)
- Abstract A66: KRas-mediated modulation of the immune response in pancreatic neoplasia. (2012) (0)
- Identification of the Role of MnSOD in EGFR-Positive Breast Cancer Development (2003) (0)
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