Dan Tawfik
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Evolutionary biochemsitry researcher
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Dan Tawfik's Degrees
- Bachelors Biochemistry University of California, Berkeley
Why Is Dan Tawfik Influential?
(Suggest an Edit or Addition)According to Wikipedia, Dan Salah Tawfik was an Israeli biochemist, best known for his contributions in protein engineering, evolutionary biochemistry and, more particularly, enzyme evolution. Biography Tawfik was born in Jerusalem to a family of Jewish immigrants originally from Iraq. He received his BSc in chemistry and biochemistry and MSc in biotechnology from the Hebrew University in Jerusalem, and his PhD from the Weizmann Institute of Science . He then moved to the United Kingdom where, after two years of postdoctoral research working under Alan Fersht at the University of Cambridge and at the Medical Research Council Centre for Protein Engineering, he became a senior research fellow at Sidney Sussex College and at the Centre for Protein Engineering, where he was appointed group leader in 1999. In 2001 he joined the Department of Biological Chemistry at the Weizmann Institute of Science and held the Nella and Leon Benoziyo Professorial Chair of Biochemistry from 2010. Tawfik was Vice-Chair of the Scientific Council of the Weizmann Institute of Science from 2019 until the time of his death.
Dan Tawfik's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Kemp elimination catalysts by computational enzyme design (2008) (1139)
- Enzyme promiscuity: a mechanistic and evolutionary perspective. (2010) (1102)
- Man-made cell-like compartments for molecular evolution (1998) (901)
- The 'evolvability' of promiscuous protein functions (2005) (768)
- The moderately efficient enzyme: evolutionary and physicochemical trends shaping enzyme parameters. (2011) (749)
- Protein Dynamism and Evolvability (2009) (732)
- Antibody Multispecificity Mediated by Conformational Diversity (2003) (693)
- Stability effects of mutations and protein evolvability. (2009) (615)
- Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes (2004) (589)
- Enzyme promiscuity: evolutionary and mechanistic aspects. (2006) (588)
- Conformational diversity and protein evolution--a 60-year-old hypothesis revisited. (2003) (496)
- How Protein Stability and New Functions Trade Off (2008) (467)
- Structure-reactivity studies of serum paraoxonase PON1 suggest that its native activity is lactonase. (2005) (429)
- Robustness–epistasis link shapes the fitness landscape of a randomly drifting protein (2006) (386)
- Local fitness landscape of the green fluorescent protein (2016) (383)
- The stability effects of protein mutations appear to be universally distributed. (2007) (374)
- Mutational effects and the evolution of new protein functions (2010) (362)
- Amplification of complex gene libraries by emulsion PCR (2006) (346)
- Miniaturising the laboratory in emulsion droplets. (2006) (343)
- Chaperonin overexpression promotes genetic variation and enzyme evolution (2009) (330)
- Directed evolution of an extremely fast phosphotriesterase by in vitro compartmentalization (2003) (307)
- Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization. (2004) (279)
- Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability (2016) (256)
- The latent promiscuity of newly identified microbial lactonases is linked to a recently diverged phosphotriesterase. (2006) (244)
- Initial Mutations Direct Alternative Pathways of Protein Evolution (2011) (242)
- Intense neutral drifts yield robust and evolvable consensus proteins. (2008) (236)
- Messy biology and the origins of evolutionary innovations. (2010) (225)
- The Catalytic Histidine Dyad of High Density Lipoprotein-associated Serum Paraoxonase-1 (PON1) Is Essential for PON1-mediated Inhibition of Low Density Lipoprotein Oxidation and Stimulation of Macrophage Cholesterol Efflux* (2006) (224)
- Advances in laboratory evolution of enzymes. (2008) (216)
- High-throughput screening of enzyme libraries: thiolactonases evolved by fluorescence-activated sorting of single cells in emulsion compartments. (2005) (214)
- High affinity, stability, and lactonase activity of serum paraoxonase PON1 anchored on HDL with ApoA-I. (2005) (211)
- Do viral proteins possess unique biophysical features? (2009) (209)
- Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59 (2012) (196)
- Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis. (2012) (195)
- Directed evolution by in vitro compartmentalization (2006) (195)
- High-throughput screens and selections of enzyme-encoding genes. (2005) (187)
- Erratum: Diminishing returns and tradeoffs constrain the laboratory optimization of an enzyme (2012) (185)
- Directed evolution of hydrolases for prevention of G-type nerve agent intoxication. (2011) (179)
- The molecular basis of phosphate discrimination in arsenate-rich environments (2012) (178)
- Directed enzyme evolution: beyond the low-hanging fruit. (2012) (172)
- Identification of the algal dimethyl sulfide–releasing enzyme: A missing link in the marine sulfur cycle (2015) (168)
- The Histidine 115-Histidine 134 Dyad Mediates the Lactonase Activity of Mammalian Serum Paraoxonases* (2006) (160)
- Protein engineers turned evolutionists (2007) (156)
- Optimization of the in-silico-designed kemp eliminase KE70 by computational design and directed evolution. (2011) (155)
- Evolutionary optimization of computationally designed enzymes: Kemp eliminases of the KE07 series. (2010) (154)
- The universality of enzymatic rate-temperature dependency. (2014) (153)
- In vitro compartmentalization by double emulsions: sorting and gene enrichment by fluorescence activated cell sorting. (2004) (151)
- Noise–mean relationship in mutated promoters (2012) (149)
- What makes a protein fold amenable to functional innovation? Fold polarity and stability trade-offs. (2013) (145)
- Latent evolutionary potentials under the neutral mutational drift of an enzyme (2007) (144)
- The specificity of cross‐reactivity: Promiscuous antibody binding involves specific hydrogen bonds rather than nonspecific hydrophobic stickiness (2003) (140)
- Catalytic versatility and backups in enzyme active sites: the case of serum paraoxonase 1. (2012) (139)
- Off-the-shelf proteins that rival tailor-made antibodies as catalysts (1996) (135)
- Directed evolution of proteins for heterologous expression and stability. (2005) (134)
- The 192R/Q polymorphs of serum paraoxonase PON1 differ in HDL binding, lipolactonase stimulation, and cholesterol efflux Published, JLR Papers in Press, August 16, 2006.s⃞ (2006) (134)
- Man-made enzymes--from design to in vitro compartmentalisation. (2000) (133)
- Arsenate replacing phosphate: alternative life chemistries and ion promiscuity. (2011) (133)
- Reconstructing a missing link in the evolution of a recently diverged phosphotriesterase by active-site loop remodeling. (2012) (131)
- Directed enzyme evolution via small and effective neutral drift libraries (2008) (126)
- Shared promiscuous activities and evolutionary features in various members of the amidohydrolase superfamily. (2005) (118)
- Incorporating Synthetic Oligonucleotides via Gene Reassembly (ISOR): a versatile tool for generating targeted libraries. (2007) (116)
- Microbead display by in vitro compartmentalisation: selection for binding using flow cytometry (2002) (111)
- Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase (2009) (109)
- The Evolutionary Origins of Detoxifying Enzymes (2013) (106)
- Automated Design of Efficient and Functionally Diverse Enzyme Repertoires. (2018) (103)
- Altering the sequence specificity of HaeIII methyltransferase by directed evolution using in vitro compartmentalization. (2004) (103)
- The robustness and innovability of protein folds. (2014) (102)
- Divergence and Convergence in Enzyme Evolution: Parallel Evolution of Paraoxonases from Quorum-quenching Lactonases* (2011) (101)
- catELISA: a facile general route to catalytic antibodies. (1993) (100)
- Evolution of new protein topologies through multistep gene rearrangements (2006) (100)
- Accuracy-rate tradeoffs: how do enzymes meet demands of selectivity and catalytic efficiency? (2014) (98)
- Directed evolution of phosphotriesterase from Pseudomonas diminuta for heterologous expression in Escherichia coli results in stabilization of the metal-free state. (2005) (97)
- Unexpectedly high occurrence of catalytic antibodies in MRL/lpr and SJL mice immunized with a transition-state analog: is there a linkage to autoimmunity? (1995) (93)
- Enhanced stereoselective hydrolysis of toxic organophosphates by directly evolved variants of mammalian serum paraoxonase (2006) (93)
- Evolution of chalcone isomerase from a noncatalytic ancestor (2018) (89)
- Evolved stereoselective hydrolases for broad-spectrum G-type nerve agent detoxification. (2012) (89)
- Engineering V-type nerve agents detoxifying enzymes using computationally focused libraries. (2013) (88)
- Metamorphic proteins mediate evolutionary transitions of structure (2010) (88)
- Negative Epistasis and Evolvability in TEM-1 β-Lactamase--The Thin Line between an Enzyme's Conformational Freedom and Disorder. (2015) (88)
- Structure and kinetics of a transient antibody binding intermediate reveal a kinetic discrimination mechanism in antigen recognition. (2005) (85)
- Chromogenic and Fluorogenic Assays for the Lactonase Activity of Serum Paraoxonases (2006) (84)
- Slow protein evolutionary rates are dictated by surface–core association (2011) (82)
- Directed evolution of the promiscuous esterase activity of carbonic anhydrase II. (2005) (82)
- The Moderately Efficient Enzyme: Futile Encounters and Enzyme Floppiness. (2015) (81)
- Potential role of phenotypic mutations in the evolution of protein expression and stability (2009) (80)
- The development of human sera tests for HDL-bound serum PON1 and its lipolactonase activitys⃞ Published, JLR Papers in Press, April 13, 2007. (2007) (80)
- Rescue of conformational dynamics in enzyme catalysis by directed evolution (2017) (78)
- Quantifying and understanding the fitness effects of protein mutations: Laboratory versus nature (2016) (78)
- De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints (2016) (78)
- Metabolite-Enzyme Coevolution: From Single Enzymes to Metabolic Pathways and Networks. (2018) (77)
- Design and in vitro realization of carbon-conserving photorespiration (2018) (77)
- Catalytic and binding poly‐reactivities shared by two unrelated proteins: The potential role of promiscuity in enzyme evolution (2001) (77)
- Following evolutionary paths to protein-protein interactions with high affinity and selectivity (2009) (77)
- On the Potential Origins of the High Stability of Reconstructed Ancestral Proteins. (2016) (77)
- Systematic Mapping of Protein Mutational Space by Prolonged Drift Reveals the Deleterious Effects of Seemingly Neutral Mutations (2015) (75)
- Enzyme engineering: reaching the maximal catalytic efficiency peak. (2017) (73)
- Enzyme engineering by targeted libraries. (2013) (70)
- Structural Convergence in the Active Sites of a Family of Catalytic Antibodies (1997) (69)
- Ohno's model revisited: measuring the frequency of potentially adaptive mutations under various mutational drifts. (2008) (69)
- A Bird's-Eye View of Enzyme Evolution: Chemical, Physicochemical, and Physiological Considerations. (2018) (68)
- An Ancient Fingerprint Indicates the Common Ancestry of Rossmann-Fold Enzymes Utilizing Different Ribose-Based Cofactors (2016) (67)
- Protein engineers turned evolutionists-the quest for the optimal starting point. (2019) (66)
- Reconstruction of functional beta-propeller lectins via homo-oligomeric assembly of shorter fragments. (2007) (65)
- Investigating the target recognition of DNA cytosine-5 methyltransferase HhaI by library selection using in vitro compartmentalisation. (2002) (65)
- Directed evolution of protein inhibitors of DNA-nucleases by in vitro compartmentalization (IVC) and nano-droplet delivery. (2005) (64)
- Simple method for selecting catalytic monoclonal antibodies that exhibit turnover and specificity. (1990) (63)
- Functional Proteins from Short Peptides: Dayhoff's Hypothesis Turns 50. (2016) (62)
- Loop Grafting and the Origins of Enzyme Species (2006) (61)
- Directed evolution of sulfotransferases and paraoxonases by ancestral libraries. (2011) (60)
- Catalytic metal ion rearrangements underline promiscuity and evolvability of a metalloenzyme. (2013) (57)
- Characterization of Proton-Transfer Catalysis by Serum Albumins (2000) (56)
- Efficient Catalysis of Proton Transfer by Synzymes (1997) (55)
- Simple yet functional phosphate-loop proteins (2018) (51)
- Crystal structure of a catalytic antibody Fab with esterase-like activity. (1994) (51)
- On the magnitude and specificity of medium effects in enzyme-like catalysts for proton transfer. (2001) (49)
- Protein insertions and deletions enabled by neutral roaming in sequence space. (2013) (49)
- Overcoming an optimization plateau in the directed evolution of highly efficient nerve agent bioscavengers (2017) (49)
- Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro (2014) (48)
- Role of chemistry versus substrate binding in recruiting promiscuous enzyme functions. (2011) (47)
- Functional β-propeller lectins by tandem duplications of repetitive units. (2011) (47)
- The evolution of oxygen-utilizing enzymes suggests early biosphere oxygenation (2021) (47)
- On the evolution of chaperones and cochaperones and the expansion of proteomes across the Tree of Life (2020) (46)
- Directed evolution of serum paraoxonase PON3 by family shuffling and ancestor/consensus mutagenesis, and its biochemical characterization. (2009) (45)
- DddD is a CoA-transferase/lyase producing dimethyl sulfide in the marine environment. (2014) (45)
- In vivo administration of BL-3050: highly stable engineered PON1-HDL complexes (2009) (43)
- ApoE induces serum paraoxonase PON1 activity and stability similar to ApoA-I. (2010) (43)
- Mechanisms of Protein Sequence Divergence and Incompatibility (2013) (42)
- The Evolutionary Potential of Phenotypic Mutations (2015) (41)
- On the emergence of P-Loop NTPase and Rossmann enzymes from a Beta-Alpha-Beta ancestral fragment (2020) (40)
- Post-exposure treatment of VX poisoned guinea pigs with the engineered phosphotriesterase mutant C23: a proof-of-concept study. (2014) (39)
- The Antioxidant Role of Paraoxonase 1 and Vitamin E in Three Autoimmune Diseases (2012) (38)
- Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro (2016) (38)
- Native Mass Spectrometry of Recombinant Proteins from Crude Cell Lysates. (2017) (37)
- Correlated Occurrence and Bypass of Frame-Shifting Insertion-Deletions (InDels) to Give Functional Proteins (2013) (37)
- Conformational changes affect binding and catalysis by ester-hydrolysing antibodies. (1999) (37)
- Avoiding and controlling double transformation artifacts. (2007) (36)
- Flow cytometry: a new method to investigate the properties of water-in-oil-in-water emulsions. (2004) (35)
- Evolutionary transitions to new DNA methyltransferases through target site expansion and shrinkage (2012) (35)
- Differences in the biochemical properties of esterolytic antibodies correlate with structural diversity. (1994) (34)
- Catalytic stimulation by restrained active-site floppiness--the case of high density lipoprotein-bound serum paraoxonase-1. (2015) (34)
- Stereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers. (2010) (34)
- Assessing the prediction fidelity of ancestral reconstruction by a library approach. (2015) (33)
- Promiscuous methylation of non-canonical DNA sites by HaeIII methyltransferase. (2002) (33)
- Spontaneous Emergence of S-Adenosylmethionine and the Evolution of Methylation. (2016) (31)
- Antibiotic resistance evolved via inactivation of a ribosomal RNA methylating enzyme (2016) (30)
- Primordial emergence of a nucleic acid-binding protein via phase separation and statistical ornithine-to-arginine conversion (2020) (28)
- How evolution shapes enzyme selectivity – lessons from aminoacyl‐tRNA synthetases and other amino acid utilizing enzymes (2019) (28)
- Short and simple sequences favored the emergence of N-helix phospho-ligand binding sites in the first enzymes (2020) (27)
- Primordial emergence of a nucleic acid binding protein via phase separation and statistical ornithine to arginine conversion (2020) (27)
- pH on-off switching of antibody-hapten binding by site-specific chemical modification of tyrosine. (1994) (26)
- Exogenous immunoglobulin downregulates T‐cell receptor signaling and cytokine production (2012) (26)
- 1,8-Diazabicyclo[5.4.0]undecene Mediated Transesterification of p-Nitrophenyl Phosphonates: A Novel Route to Phosphono Esters (1993) (25)
- Mechanism of hydrolysis and aminolysis of homocysteine thiolactone. (2006) (24)
- Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability (2018) (24)
- Diadenosine tetraphosphate (Ap4A) – an E. coli alarmone or a damage metabolite? (2017) (23)
- Bridging Themes: Short Protein Segments Found in Different Architectures (2020) (23)
- A “Fuzzy”-Logic Language for Encoding Multiple Physical Traits in Biomolecules (2014) (22)
- The Dimethylsulfoniopropionate (DMSP) Lyase and Lyase-Like Cupin Family Consists of Bona Fide DMSP lyases as Well as Other Enzymes with Unknown Function. (2018) (22)
- Paraoxonase-1 and clopidogrel efficacy (2011) (22)
- Catalytic monoclonal antibodies: tailor-made, enzyme-like catalysts for chemical reactions (1989) (21)
- 8.03 – Enzyme Promiscuity – Evolutionary and Mechanistic Aspects (2010) (21)
- Single treatment of VX poisoned guinea pigs with the phosphotriesterase mutant C23AL: Intraosseous versus intravenous injection. (2016) (20)
- TRINS: a method for gene modification by randomized tandem repeat insertions. (2012) (20)
- Efficient and selective p-nitrophenyl-ester-hydrolyzing antibodies elicited by a p-nitrobenzyl phosphonate hapten. (1997) (20)
- The Limited Information Capacity of Cross-Reactive Sensors Drives the Evolutionary Expansion of Signaling. (2019) (19)
- Protein Promiscuity: Drug Resistance and Native Functions—HIV-1 Case (2005) (19)
- Bacilli glutamate dehydrogenases diverged via coevolution of transcription and enzyme regulation (2017) (19)
- Catalytic antibodies: A critical assessment (1994) (19)
- In vitro detoxification of cyclosarin in human blood pre-incubated ex vivo with recombinant serum paraoxonases. (2011) (19)
- Protein Promiscuity: Drug Resistance and Native Functions—HIV-1 Case (2005) (19)
- Ambiguous evidence for assigning DddQ as a dimethylsulfoniopropionate lyase and oceanic dimethylsulfide producer (2014) (18)
- Methanol-free biosynthesis of fatty acid methyl ester (FAME) in Synechocystis sp. PCC 6803. (2019) (18)
- Expression and characterization of recombinant single-chain Fv and Fv fragments derived from a set of catalytic antibodies. (1997) (17)
- A new post-intoxication treatment of paraoxon and parathion poisonings using an evolved PON1 variant and recombinant GOT1. (2016) (17)
- Determinants of cofactor binding to DNA methyltransferases: insights from a systematic series of structural variants of S-adenosylhomocysteine. (2005) (17)
- Enzyme neo- versus re-functionalization - an epistatic ratchet versus a smooth reversible transition. (2019) (17)
- Chance and pleiotropy dominate genetic diversity in complex bacterial environments (2018) (16)
- Enzyme evolution in natural products biosynthesis: target- or diversity-oriented? (2020) (16)
- Corrigendum: Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes (2004) (16)
- Hopeful (protein InDel) monsters? (2014) (16)
- On the Mechanism and Origin of Isoleucyl-tRNA Synthetase Editing against Norvaline. (2019) (14)
- Detection of catalytic monoclonal antibodies. (1992) (14)
- Gal3 Binds Gal80 Tighter than Gal1 Indicating Adaptive Protein Changes Following Duplication. (2016) (14)
- Polyamines Mediate Folding of Primordial Hyperacidic Helical Proteins (2020) (13)
- Assigning the Algal Source of Dimethylsulfide Using a Selective Lyase Inhibitor. (2017) (13)
- Nonspecific catalysis by protein surfaces (2000) (12)
- Helicase-like functions in phosphate loop containing beta-alpha polypeptides (2020) (11)
- The number and type of oxygen-utilizing enzymes indicates aerobic vs. anaerobic phenotype. (2019) (11)
- Enzyme promiscuity and evolution in light of cellular metabolism (2020) (11)
- Esterolytic antibodies as mechanistic and structural models of hydrolases-a quantitative analysis. (2002) (11)
- Dimethyl sulfide mediates microbial predator–prey interactions between zooplankton and algae in the ocean (2021) (11)
- Modification of Sulfhydryl Groups with DTNB (1996) (10)
- Peptide-RNA Coacervates as a Cradle for the Evolution of Folded Domains (2022) (10)
- Generating targeted libraries by the combinatorial incorporation of synthetic oligonucleotides during gene shuffling (ISOR). (2014) (10)
- Directed evolution of recombinant serum paraoxonase (PON) variants. (2004) (7)
- Erratum to: “The universality of enzymatic rate–temperature dependency”: [Trends in Biochemical Sciences 39 (2014) 1–7] (2014) (7)
- igh-throughput screens and selections of enzyme-encoding enes (2005) (7)
- Determining the interaction status and evolutionary fate of duplicated homomeric proteins (2020) (6)
- Protein technologies. (2009) (6)
- In vitro compartmentalization (IVC): A high-throughput screening technology using emulsions and FACS. (2004) (6)
- Bifunctional Substrate Activation via an Arginine Residue Drives Catalysis in Chalcone Isomerases (2018) (6)
- Side Chain Selective Chemical Modifications of Proteins (1996) (6)
- On the evolution of chaperones and co-chaperones and the exponential expansion of proteome complexity (2020) (6)
- Editorial overview: Biocatalysis and Biotransformation: Esoteric, Niche Enzymology. (2016) (6)
- A counter-enzyme complex regulates glutamate metabolism in Bacillus subtilis (2021) (5)
- 1,8-Diazabicyclo(5.4.0)undecene-Mediated Transesterification of p- Nitrophenyl Phosphonates: A Novel Route to Phosphono Esters. (1994) (4)
- Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance (2021) (4)
- Amidation of Carboxyl Groups (1996) (4)
- Evolution of chalcone isomerase from a non-catalytic ancestor (2017) (4)
- Diminishing returns and tradeoffs constrain the laboratory optimization of an enzyme (2012) (4)
- Modification of Tryptophan with 2-Hydroxy-5-Nitrobenzylbromide (2002) (4)
- The evolutionary history of the HUP domain (2021) (4)
- Proto‐proteins in Protocells (2021) (3)
- DddY is a bacterial dimethylsulfoniopropionate lyase representing a new cupin enzyme superfamily with unknown primary function (2017) (3)
- Funktionelle Proteine aus kurzen Peptiden: 50 Jahre nach Margaret Dayhoffs Hypothese (2016) (3)
- How gene duplication diversifies the landscape of protein oligomeric state and function (2022) (3)
- Special Issue: Special Issue on Protein Evolution and Design July 2016 (2016) (3)
- A mixture of three engineered phosphotriesterases enables rapid detoxification of the entire spectrum of known threat nerve agents. (2019) (3)
- Modification of Arginine Side Chains with p-Hydroxyphenylglyoxal (1996) (3)
- Uniform binding and negative catalysis at the origin of enzymes (2022) (3)
- A Personal Reflection on the Chemistry‐Biology Interface (2019) (2)
- Publisher Correction: Evolution of chalcone isomerase from a noncatalytic ancestor (2018) (2)
- A mixture of three engineered phosphotriesterases enables rapid detoxification of the entire spectrum of known threat nerve agents (2019) (2)
- Amidination of Lysine Side Chains (1996) (2)
- Quantifying and understanding the fitness effects of protein mutations: Laboratory versus nature (2019) (2)
- Engineering and Directed Evolution of DNA Methyltransferases. (2016) (2)
- Nitration of Tyrosines (1996) (2)
- Quinone Methide‐Based Organophosphate Hydrolases Inhibitors: Trans Proximity Labelers versus Cis Labeling Activity‐Based Probes (2020) (2)
- Characterization of ancestral Fe/Mn superoxide dismutases indicates their cambialistic origin (2022) (1)
- In Vitro Compartmentalization (IVC) and Other High‐Throughput Screens of Enzyme Libraries (2011) (1)
- From Phosphonates to Catalytic Antibodies. A Novel Route to Phosphonoester Transition State Analogs and Haptens (1993) (1)
- Perspectives in protein engineering and complementary technologies, Oxford, UK, September 13–17, 1994 (1995) (1)
- Editorial (2016) (1)
- In silico designed of an improved Kemp eliminase KE70 mutant by computational design and directed evolution (2011) (1)
- Developing a Carbon-Conserving Photorespiration Bypass Pathway through Ancestral Genome Mining and Engineering (2020) (1)
- Erratum to: Bridging themes: short protein segments found in different architectures (2021) (1)
- Utilization of diverse organophosphorus pollutants by marine bacteria (2022) (1)
- Innovation and tinkering in the evolution of oxidases (2022) (1)
- Ethoxyformylation of Histidine (1996) (1)
- Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance. (2022) (1)
- Biochemical Profiling of DMSP Lyases. (2018) (1)
- Dimethyl sulfide acts as eat-me signal during microbial predator-prey interactions in the ocean (2021) (1)
- Editorial overview: Engineering and design. (2016) (1)
- Catalytic Antibodies as Mechanistic and Structural Models of Hydrolytic Enzymes (2008) (1)
- Polyamines Mediate Folding of Primordial Hyper-Acidic Helical Proteins (2020) (0)
- Protein evolution – a reconstructive approach (363.2) (2014) (0)
- Solution structure of a phosphate-loop protein (2018) (0)
- serum paraoxonase by directed evolution (2004) (0)
- 163D structure of mammalian paraoxonase at 2.2 Å resolution (2006) (0)
- Preface. (2020) (0)
- Serum paraoxonase-1 by directed evolution at pH 6.5 (2012) (0)
- Serum paraoxonase-1 by directed evolution with the K192Q mutation (2015) (0)
- On the Origins of Enzymes: Phosphate-Binding Polypeptides Mediate Phosphoryl Transfer to Synthesize Adenosine Triphosphate (2023) (0)
- Molecular Evolution of Human PON to Design Enhanced Catalytic Efficiency for Hydrolysis of Nerve Agents (2011) (0)
- Designed protein KE59 R1 7/10H with G130S mutation (2012) (0)
- Chance and pleiotropy dominate genetic diversity in complex bacterial environments (2019) (0)
- Native or promiscuous? Analyzing putative dimethylsulfoniopropionate lyases using a substrate proofing approach (2017) (0)
- Room temperature crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying R164S/G238S mutations (2015) (0)
- Crystal structure of chalcone isomerase engineered from ancestral inference (ancCHI (2018) (0)
- A Structural Biology and Protein Engineering Approach to the Development of Antidotes against the Inhibition of Human Acetylcholinesterase by OP-based Nerve Agents (2015) (0)
- Crystal Structure of Chalcone Isomerase from Medicago Truncatula Complexed with (2S) Naringenin (2019) (0)
- The crystal structures of two fragments truncated from 5-bladed beta-propeller lectin, tachylectin-2 (Lib2-D2-15) (2010) (0)
- Repertoires of functionally diverse enzymes through computational design at epistatic active-site positions (2018) (0)
- Crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying G238S/E104K mutations (2015) (0)
- Serum paraoxonase-1 by directed evolution with the L69G/H134R/F222S/T332S mutations (2019) (0)
- Engineering of Paraoxonases for Pre- and Post-treatment of Intoxication by a Broad Spectrum of Nerve Agents and Pesticides (2014) (0)
- Serum paraoxonase-1 by directed evolution at pH 6.5 in complex with 2-hydroxyquinoline (2012) (0)
- Engineered glycolyl-CoA reductase comprising 8 mutations with bound NADP+ (2018) (0)
- Preface. (2020) (0)
- Crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying R164S/G238S mutation in complex with boron-based inhibitor EC25 (2015) (0)
- Designed protein KE59 R13 3/11H with benzotriazole (2012) (0)
- Stable, high-expression variant of human acetylcholinesterase (2016) (0)
- Crystal Structure of Chalcone Isomerase from Medicago Sativa with the G95S mutation. (2019) (0)
- Crystal Structure of Chalcone Isomerase from Medicago Sativa with the G95T mutation (2019) (0)
- The evolutionary history of class I aminoacyl-tRNA synthetases indicates early statistical translation (2022) (0)
- Round 18 Arylesterase Variant of Phosphotriesterase with Bound Transition State Analog (2013) (0)
- Round 18 Arylesterase Variant of Phosphotriesterase (2013) (0)
- Off-the-Shelf Proteins that Rival Tailor-Made Antibodies as Catalysts. (1997) (0)
- From chance to necessity in the evolution of an antibiotic resistance gene (2010) (0)
- Serum paraoxonase PON1 and its interactions with HDL (2008) (0)
- IgE Fv SPE7 complexed with a recombinant thioredoxin (2004) (0)
- Loss of homomeric interactions and heteromers formation is the long-term fate of duplicated homomers (2020) (0)
- Crystal structure of chalcone isomerase engineered from ancestral inference complexed with naringenin (ancCC) (2018) (0)
- Free conformation Ab2 of the IgE SPE-7 (2004) (0)
- Phosphotriesterases for treating or preventing organophosphate exposure associated damage (2017) (0)
- Fv Structure of the IgE SPE-7 in complex with acenaphthenequinone (2004) (0)
- Widespread Utilization of Diverse Organophosphate Pollutants by Marine Bacteria (2021) (0)
- Noise-mean relationship in mutated promoters Material (2012) (0)
- Serum paraoxonase-1 by directed evolution with the L69S/H115W/F222S mutations (2019) (0)
- catELISAELISA-based detection of catalytic antibodies and enzymes1 (1996) (0)
- Fv IgE SPE-7 in complex with Alizarin Red (2004) (0)
- Subatomic resolution structure of a high affinity periplasmic phosphate-binding protein (PfluDING) bound with phosphate at pH 4.5 (2012) (0)
- The 3D structure of chain D, cyclase subunit of imidazoleglycerol_evolvedcerolphosphate synthase (2008) (0)
- Structural Characterization of the Emergence and Evolution of Catalysis in the Chalcone Isomerase Family Fold (2016) (0)
- Crystal structure of Ancestral variant b9 of SULT 1A1 in complex with PAP and p-nitrophenol (2011) (0)
- Isolement d'enzymes (1997) (0)
- Structure of OpdA mutant (G60A/A80V/R118Q/K185R/Q206P/D208G/I260T/G273S) (2010) (0)
- How do enzymes evolve? (2018) (0)
- Designed protein KE59 R13 3/11H (2012) (0)
- The crystal structures of two fragments truncated from 5-bladed beta-propeller lectin, tachylectin-2 (Lib1-B7-18 and Lib2-D2-15) (2010) (0)
- SPE7:Anthrone Complex (2005) (0)
- Crystal structure of Ancestral variant b9 of SULT 1A1 in complex with PAP and 3-CyC (2011) (0)
- Rescue of conformational dynamics in enzyme catalysis by directed evolution (2018) (0)
- Designed protein KE59 R5_11/5F (2012) (0)
- Proteine de liaison modifiee chimiquement (1994) (0)
- Crystal structure of stabilized TEM-1 beta-lactamase variant v.13 (2013) (0)
- Distributions of the relative fitness effect values ( W rel ) for all possible single nucleotide mutations along M.HaeIII gene. (2015) (0)
- A Structural Biology and Protein Engineering Approach to the Engineering Highly Proficient Catalytic Bioscavengers for In Vivo Detoxification of a Broad Spectrum of Nerve Agents (2016) (0)
- Structure of OpdA mutant (G60A/A80V/S92A/R118Q/K185R/Q206P/D208G/I260T/G273S) with diethyl 4-methoxyphenyl phosphate bound in the active site (2010) (0)
- Correction to “Peptide-RNA Coacervates as a Cradle for the Evolution of Folded Domains” (2022) (0)
- Crystal structure of TEM-1 beta-lactamase in complex with boron-based inhibitor EC25 (2015) (0)
- The alpha-esterase-7 carboxylesterase, E3, from the blowfly Lucilia cuprina (2013) (0)
- Crystal structure of the alpha-esterase-7 carboxyl esterase (dimer), E3, from Lucilia cuprina (2013) (0)
- Round 18 Arylesterase Variant of Phosphotriesterase with Bound Cacodylate (2013) (0)
- Structural studies of catalytic antibodies with esterase activity (1996) (0)
- Following evolutionary paths to high affinity and selectivity protein-protein interactions using Colicin7 and Immunity proteins (2009) (0)
- Free conformation Ab1 of the IgE SPE-7 (2004) (0)
- Optical sorting process (2000) (0)
- Fv Structure of the IgE SPE-7 in complex with DNP-Ser (immunising hapten) (2004) (0)
- Making the paper: Dan Tawfik & Nobuhiko Tokuriki (2009) (0)
- In vitro sorting process (1998) (0)
- An in vitro method of sorting (1998) (0)
- Phosphotriesterase PTE_A53_1 (2019) (0)
- Phosphotriesterase PTE_C23M_1 (2019) (0)
- Optical classification procedure. (2000) (0)
- Phosphotriesterase PTE_C23_3 (2019) (0)
- Phosphotriesterase PTE_C23_5 (2019) (0)
- Une methode pour augmenter la concentration d'acides nucleiques (1998) (0)
- Phosphotriesterase PTE_C23_7 (2019) (0)
- In vitro sort method (1998) (0)
- Phosphotriesterase PTE_C23M_2 (2019) (0)
- Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro (2015) (0)
- Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro (2014) (0)
- Phosphotriesterase PTE_C23_4 (2019) (0)
- 421.4: Evolution of Thromboelastography Parameters During Pediatric Liver Transplantation (2022) (0)
- Transduction of hTR into Hematopoietic Stem Cells Increases Telomerase Activity (2008) (0)
- Measuring Innovation in Carver County (2016) (0)
- Phosphotriesterase PTE_C23_6 (2019) (0)
- Method for increasing the concentration of nucleic acid molecules (1998) (0)
- Phosphotriesterase PTE_C23_2 (2019) (0)
- selektion method in vitro (1998) (0)
- Phosphotriesterase PTE_C23M_4 (2019) (0)
- Phosphotriesterase PTE_C23_A203L_3 (2019) (0)
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