Daniel j. Cua

Daniel j. Cua's AcademicInfluence.com Rankings

Daniel j. Cua

Biology

#11663

World Rank

#15075

Historical Rank

Immunology

#763

World Rank

#785

Historical Rank

biology Degrees

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Biology

Daniel j. Cua's Degrees

PhD Immunology Stanford University
Doctorate Medicine Stanford University

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Daniel j. Cua's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation (2005) (4179)
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells (2006) (3309)
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain (2003) (3016)
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. (2006) (2263)
Development, cytokine profile and function of human interleukin 17–producing helper T cells (2007) (2100)
Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation (2003) (1810)
IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. (2006) (1574)
TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology (2007) (1459)
Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction (2006) (1358)
In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines (2002) (1250)
The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing (2014) (1176)
Generation of Pathogenic Th17 Cells in the Absence of TGF-β Signaling (2010) (1126)
Innate IL-17-producing cells: the sentinels of the immune system (2010) (1024)
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo (2009) (1020)
IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4−CD8− entheseal resident T cells (2012) (910)
Interleukin-23 drives innate and T cell–mediated intestinal inflammation (2006) (853)
Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. (2007) (786)
Understanding the IL-23-IL-17 immune pathway. (2006) (783)
Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals. (2009) (781)
IL‐12 and IL‐23: master regulators of innate and adaptive immunity (2004) (779)
Th17 cell differentiation: the long and winding road. (2008) (721)
Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category (2008) (708)
Fate mapping of interleukin 17-producing T cells in inflammatory responses (2011) (646)
IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases (2015) (615)
IL-23 plays a key role in Helicobacter hepaticus–induced T cell–dependent colitis (2006) (613)
Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis. (2006) (613)
Innate IL-17-producing cells: the sentinels of the immune system (2010) (595)
The IL-17 Family of Cytokines in Health and Disease. (2019) (580)
RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota (2011) (559)
Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability. (2015) (506)
Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells (2010) (476)
Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury (2009) (472)
Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling (2009) (458)
IL-25 regulates Th17 function in autoimmune inflammation (2007) (405)
Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract (2006) (380)
IL-27 Blocks RORc Expression to Inhibit Lineage Commitment of Th17 Cells (2009) (332)
IL-17 Regulates Adipogenesis, Glucose Homeostasis, and Obesity (2010) (324)
The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis. (2007) (322)
The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology. (2012) (309)
Commensal-dependent expression of IL-25 regulates the IL-23–IL-17 axis in the intestine (2008) (295)
MAIT cells are imprinted by the microbiota in early life and promote tissue repair (2019) (262)
Self-antigen-induced Th2 responses in experimental allergic encephalomyelitis (EAE)-resistant mice. Th2-mediated suppression of autoimmune disease. (1995) (225)
Transgenic Interleukin 10 Prevents Induction of Experimental Autoimmune Encephalomyelitis (1999) (216)
Th17 cell development: from the cradle to the grave (2013) (208)
The role of interleukin-10 in autoimmune disease: systemic lupus erythematosus (SLE) and multiple sclerosis (MS). (2002) (195)
The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation. (2010) (191)
Involvement of Th17 cells and the effect of anti-IL-6 therapy in autoimmune uveitis. (2009) (180)
CTL effector function within the central nervous system requires CD4+ T cells. (1998) (178)
IL-23 Provides a Limited Mechanism of Resistance to Acute Toxoplasmosis in the Absence of IL-121 (2004) (172)
A role for IL-27p28 as an antagonist of gp130-mediated signaling (2010) (168)
The link between IL-23 and Th17 cell-mediated immune pathologies. (2007) (151)
Foxp3(+) regulatory T cells promote T helper 17 cell development in vivo through regulation of interleukin-2. (2011) (151)
Interleukin-23 is sufficient to induce rapid de novo gut tumorigenesis, independent of carcinogens, through activation of innate lymphoid cells (2013) (126)
Interleukin-23-Induced Transcription Factor Blimp-1 Promotes Pathogenicity of T Helper 17 Cells. (2016) (124)
Central Nervous System Expression of IL-10 Inhibits Autoimmune Encephalomyelitis1 (2001) (120)
Immunization with Staphylococcus aureus iron regulated surface determinant B (IsdB) confers protection via Th17/IL17 pathway in a murine sepsis model (2012) (115)
Interleukin-17-Producing gd T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals (107)
LAG3+ Regulatory T Cells Restrain Interleukin‐23‐Producing CX3CR1+ Gut‐Resident Macrophages during Group 3 Innate Lymphoid Cell‐Driven Colitis (2018) (101)
IL-23 Is Required for the Development of Severe Egg-Induced Immunopathology in Schistosomiasis and for Lesional Expression of IL-171 (2008) (100)
Epithelial Cell-Derived IL-25, but Not Th17 Cell-Derived IL-17 or IL-17F, Is Crucial for Murine Asthma (2012) (100)
Cytokines that regulate autoimmunity. (2008) (98)
Kinetics of Cytokine mRNA Expression in the Central Nervous System Following Lethal and Nonlethal Coronavirus-Induced Acute Encephalomyelitis (1997) (92)
Dual Roles for Regulatory T-cell Depletion and Costimulatory Signaling in Agonistic GITR Targeting for Tumor Immunotherapy. (2017) (89)
Exposure to T helper 2 cytokines in vivo before encounter with antigen selects for T helper subsets via alterations in antigen-presenting cell function. (1996) (79)
Activation of regulatory cells suppresses experimental allergic encephalomyelitis via secretion of IL-10. (1999) (79)
Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis (2010) (78)
Autoimmune memory T helper 17 cell function and expansion are dependent on interleukin-23. (2013) (74)
Macrophages regulate induction of delayed‐type hypersensitivity and experimental allergic encephalomyelitis in SJL mice (1995) (72)
IL-23-mediated mononuclear phagocyte crosstalk protects mice from Citrobacter rodentium-induced colon immunopathology (2015) (68)
Natural Occurring IL-17 Producing T Cells Regulate the Initial Phase of Neutrophil Mediated Airway Responses1 (2009) (66)
Central Nervous System Expression of IL-10 Inhibits Autoimmune Encephalomyelitis (2000) (66)
TGF-β, a 'double agent' in the immune pathology war (2006) (62)
Rationale and safety of anti-interleukin-23 and anti-interleukin-17A therapy (2006) (59)
In vivo effects of T helper cell type 2 cytokines on macrophage antigen-presenting cell induction of T helper subsets. (1997) (58)
Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice. (2011) (57)
Therapeutic potential of targeting IL-17 (2012) (54)
Blockade of interleukin-23 signaling results in targeted protection of the colon and allows for separation of graft-versus-host and graft-versus-leukemia responses. (2009) (53)
Tumor necrosis factor expression during mouse hepatitis virus-induced demyelinating encephalomyelitis (1995) (53)
Biomarkers of Therapeutic Response in the IL-23 Pathway in Inflammatory Bowel Disease (2012) (51)
Interleukin-12 (IL-12), but Not IL-23, Deficiency Ameliorates Viral Encephalitis without Affecting Viral Control (2009) (49)
Inhibition of RORγT Skews TCRα Gene Rearrangement and Limits T Cell Repertoire Diversity. (2016) (47)
Prostaglandin E 2 regulates Th 17 cell diff erentiation and function through cyclic AMP and EP 2 / EP 4 receptor signaling (2009) (46)
The critical role of interleukin-23 in spondyloarthropathy. (2014) (45)
Autoimmunity's collateral damage: Gut microbiota strikes 'back' (2011) (41)
Dysregulation of Suppressor of Cytokine Signaling 3 in Keratinocytes Causes Skin Inflammation Mediated by Interleukin-20 Receptor-Related Cytokines (2012) (40)
TGF-beta, a 'double agent' in the immune pathology war. (2006) (39)
Regulation of the development of acute hepatitis by IL‐23 through IL‐22 and IL‐17 production (2011) (39)
A Highly Focused Antigen Receptor Repertoire Characterizes γδ T Cells That are Poised to Make IL-17 Rapidly in Naive Animals (2015) (38)
Location of antibody epitopes within the mouse hepatitis virus nucleocapsid protein. (1994) (37)
GITR Agonism Enhances Cellular Metabolism to Support CD8+ T-cell Proliferation and Effector Cytokine Production in a Mouse Tumor Model (2018) (35)
Expression of Interferon-γ by a Coronavirus Defective-Interfering RNA Vector and Its Effect on Viral Replication, Spread, and Pathogenicity (1997) (35)
NK Cells Regulate CD4 Responses Prior to Antigen Encounter1 (2003) (34)
T Cells Doing It for Themselves: TGF-β Regulation of Th1 and Th17 Cells (2007) (33)
T cells doing it for themselves: TGF-beta regulation of Th1 and Th17 cells. (2007) (31)
IL‐17A‐producing CD30+ Vδ1 T cells drive inflammation‐induced cancer progression (2016) (31)
Essential roles of IL‐12 and dendritic cells but not IL‐23 and macrophages in lupus‐like diseases initiated by cell surface HSP gp96 (2007) (31)
A colitogenic memory CD4+ T cell population mediates gastrointestinal graft-versus-host disease. (2016) (26)
SnapShot: Cytokines II (2008) (26)
The emerging landscape of RORγt biology. (2014) (24)
Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells (2011) (23)
SnapShot: Cytokines I (2008) (23)
IL-23 and IL-2 activation of STAT5 is required for optimal IL-22 production in ILC3s during colitis (2020) (23)
IFN-γ protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophils (2012) (22)
The Myeloid Receptor PILRβ Mediates the Balance of Inflammatory Responses through Regulation of IL-27 Production (2012) (20)
Cutting Edge: CLEC5A Mediates Macrophage Function and Chronic Obstructive Pulmonary Disease Pathologies (2016) (19)
SnapShot: Cytokines IV (2008) (18)
Melatonin Lulling Th17 Cells to Sleep (2015) (18)
IL-23 Promotes TCR-mediated Negative Selection of Thymocytes through the Upregulation of IL-23 Receptor and RORγt (2014) (18)
College of Science (2009) (17)
SnapShot: Cytokines III (2008) (14)
Spondyloarthropathy: interleukin 23 and disease modification (2015) (14)
Alternative lifestyles of T cells (2008) (13)
IL-23 Is Essential for the Development of Elastase-Induced Pulmonary Inflammation and Emphysema (2016) (11)
The Orphan Nuclear Receptor ROR g t Directs the Differentiation Program of Proinflammatory IL-17 + T Helper Cells (2014) (11)
IL-23 Is Essential for the Development of Elastase-Induced Pulmonary Inflammation and Emphysema. (2016) (10)
Interleukin-23: a promising therapeutic target in seronegative spondyloarthropathy. (2013) (10)
Experimental Lung Metastases in Mice Are More Effectively Inhibited by Blockade of IL23R than IL23 (2018) (10)
Dual roles for regulatory T cell depletion and co-stimulatory signaling in agonistic GITR targeting for tumor immunotherapy (2016) (10)
Genetic control of T helper subset differentiation in Leishmania major infection of mice. (1999) (7)
A novel mechanism for IL-23 to up-regulate AICDA and promote pathogenic autoantibodies in lupus (2018) (6)
IL-26 AMPs up the TH17 arsenal (2015) (6)
IL-23 Promotes a Coordinated B Cell Germinal Center Program for Class-Switch Recombination to IgG2b in BXD2 Mice (2020) (6)
Apoptosis of JHMV-specific CTL in the CNS in the absence of CD4+ T cells. (1998) (6)
Induction and Analysis of Anti-CD40-induced Colitis in Mice. (2019) (4)
Either a Th 17 or a Th 1 eff ector response can drive autoimmunity : conditions of disease induction aff ect dominant eff ector category (2008) (4)
Role of IL-23 in mobilization of immunoregulatory nitric oxide- or superoxide-producing Gr-1+ cells from bone marrow. (2009) (4)
IL‐23 promotes the development of castration‐resistant prostate cancer (2018) (4)
IL-23 and IL-17 in pathogenesis of experimental ocular autoimmunity: requirement for IL–23 may extend beyond its role in sustaining the IL-17 effector response (129.26) (2007) (4)
Local IL-23 is required for proliferation and retention of skin-resident memory TH17 cells (2022) (4)
Interleukin-23 in perspective (2021) (3)
IL-23 and Not IL-12 Is Essential for the Development of IBD (2006) (3)
IL-23 induces apoptosis of self-reactive thymocytes in thymic negative selection by an Rorc dependent mechanism (64.19) (2011) (3)
IL-23 p19 Knockout Mice Exhibit Minimal Defects in Responses to Primary and Secondary Infection with Francisella tularensis LVS (2014) (3)
IL-23 in Health and Disease (2014) (2)
Orphan cytokine reveals IL-17 family secret. (2011) (2)
Th17 stimulation and IL17A play critical roles in the Staphylococcus aureus iron regulated surface determinant B (IsdB) mediated protection in a disseminated challenge model. (99.11) (2011) (2)
Interleukin 23 is critical in the pathogenesis of spondyloarthropathy and acts on a novel population of interleukin 23R+ entheseal resident cells (2013) (2)
IFN-γ protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophils (2012) (2)
Antibodies to ILT3 abrogate myeloid immunosuppression and enable tumor killing (2021) (2)
SS1-2 SIGIRR protein suppresses Th17 cell proliferation via negative regulation of the Interleukin-1 receptor pathway and inhibition of mTOR kinase activation (2010) (1)
IL-23 drives the expansion of pathogenic ThIL-17 cells required for autoimmune inflammation (2005) (1)
A colitogenic memory CD 4 + T cell population mediates gastrointestinal graft-versus-host disease (2016) (1)
97 IL-23 is Vital for Effector Th17 Cell Function In Vivo (2007) (1)
Correction: IL-17 Regulates Adipogenesis, Glucose Homeostasis, and Obesity (2011) (1)
Foxp3+ regulatory T cells promote Th17 development in vivo through regulation of IL-2 (2011) (1)
Activation of the TLR2-MyD88 pathway is required for in-vivo efficacy of Lipid Nanoparticle based vaccine formulation (2017) (1)
Cytokine regulation in diseases (PP-090) (2010) (1)
Th17 / Treg (SY2-1) Chairpersons: Shimon Sakaguchi, Daniel Cua (2010) (0)
Determination of the functional biology of IL‐25 (2008) (0)
IL-17 — a novel adipose tissue cytokine with anti-adipogenic and pro-osteogenic properties (114.6) (2011) (0)
Commensal‐dependent regulation of the IL‐17 cytokine family governs susceptibility to intestinal inflammation (2008) (0)
RORgT modulates key features in adult thymopoiesis (HEM2P.235) (2015) (0)
SS1-4 Foxp3+ Tregs promote Th17 development in vivo by regulating IL-2 (2010) (0)
, F M encephalomyelitis . mouse hepatitis virus-induced demyelinating Tumor necrosis factor expression during (1995) (0)
, without Affecting Viral Control Deficiency Ameliorates Viral Encephalitis Interleukin-12 ( IL-12 ) , but Not IL-23 (2009) (0)
Homeostasis, and Obesity IL-17 Regulates Adipogenesis, Glucose (2010) (0)
Brain Poster Session: Inflammation (2009) (0)
S745 Differential and Combinatorial Mechanism of Action of Golimumab and Guselkumab in Ulcerative Colitis Induction Therapy: IL-23 Blockade Drives Restoration of Normal Epithelium and Mucosal Healing (2022) (0)
IL-25 the IL-23-IL-17 axis in the (2008) (0)
Schistosomiasis and for Lesional Expression Severe Egg-Induced Immunopathology in IL-23 Is Required for the Development of (2017) (0)
IL-23 is essential for the switching between Tfh-IFN-γ and Tfh-IL-17 in lupus (2019) (0)
Interleukin-23-Induced Tra nscription Factor Blimp-1 Promotes Pathogenicity of T Helper 17 Cells Highlights d IL-23-dependent Blimp-1 enhances Th 17 pathogenic factors including GM-CSF and IFN-g d Distal Lck-Cre-mediatedBlimp-1 deletion in peripheral T cells ameliorates (2015) (0)
Prolonged Airway Inflammation And Responsiveness In Mice Sensitized Via The Skin Is IL-23-Dependent (2011) (0)
Lineage Commitment of Th 17 Cells IL-27 Blocks RORc Expression to Inhibit (2009) (0)
The Emerging Landscape of RORgt Biology (2014) (0)
IL-23 induces IRF5 and polarizes inflammatory M1 macrophages to promote inflammation in a mouse model of arthritis (171.5) (2012) (0)
Coordinate Expression of Beta 2 Integrins and the Interleukin 23 Receptor Define a Pathogenic CD4+ T Cell Population That Induces Colonic Inflammation during Graft Versus Host Disease (2014) (0)
IFN-{gamma} protects from IL-17 mediated lethal encephalomyelitis independent of neutrophils (2011) (0)
Uses of mammalian cytokine il-23; related reagents (2003) (0)
IL-23 controls autoimmunity by maintaining the integrity of marginal zone barrier that clears apoptotic bodies (P4178) (2013) (0)
Mediated Airway Responses Regulate the Initial Phase of Neutrophil Natural Occurring IL-17 Producing T Cells (2009) (0)
32 IL-27P28 Protects Mice From EAE (2007) (0)
IL-23 promotes autoimmune Th17 memory formation and function (59.6) (2012) (0)
IL-23 inhibits autoimmunity by facilitating clearance of apoptotic bodies in the marginal zone (171.26) (2012) (0)
IFN-γ protects from IL-17 mediated lethal encephalomyelitis independent of neutrophils (114.4) (2011) (0)
93 Essential Role for IL-23 but not for the Th17 Effector Response in Pathogenesis of Experimental Ocular Autoimmunity (2007) (0)
ID: 184: RORγt regulation of IL-23 and Th17 responses in autoimmunity (2015) (0)
Use of IL-23 and IL-17 antagonists for the treatment of autoimmune inflammatory eye disease (2006) (0)
Use of antagonists of IL-23 and IL-17 to treat autoimmune ocular inflammatory disease. (2006) (0)
Psoriasis and skin diseases (WS-055) Chairpersons: Masayuki Amagai, Akira Takashima (2010) (0)
Systemicinflammatoryresponsesyndrome(SIRS)isapotentiallylethalcondition,asitcanprogressto shock,multi-organfailure,anddeath.Itcanbetriggeredbyinfection,tissuedamage,orhemorrhage.The roleoftissueinjuryintheprogressionfromSIRStoshockisincompletelyunderstood.Here,weshowthat treatmentofmicewithconcanava (2011) (0)
Inhibits Autoimmune Encephalomyelitis Central Nervous System Expression of IL-10 (0)
Foxp3+ regulatory T cells promote Th17 development in vivo through regulation of IL-2 (168.16) (2011) (0)
The Emerging Landscape of RORg tB iology (2014) (0)
Regulate the Initial Phase of Neutrophil Natural Occurring IL-17 Producing T Cells (2009) (0)
Absence of IL-12 Resistance to Acute Toxoplasmosis in the IL-23 Provides a Limited Mechanism of (2013) (0)
cytokine IL-23 uses mammal; related reagents. (2003) (0)

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What Schools Are Affiliated With Daniel j. Cua?

Daniel j. Cua is affiliated with the following schools:

University of Southern California