Daniel L. Simmons

Daniel L. Simmons's AcademicInfluence.com Rankings

Daniel L. Simmons

Chemistry

#1225

World Rank

#1896

Historical Rank

#480

USA Rank

chemistry Degrees

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Chemistry

Daniel L. Simmons's Degrees

Bachelors Chemistry University of California, Berkeley
PhD Chemistry Stanford University

Why Is Daniel L. Simmons Influential?

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According to Wikipedia, Daniel L. Simmons is a professor of chemistry and former director of the Cancer Research Center at Brigham Young University . He was the discoverer of the COX-2 enzyme that is the target of celecoxib and other COX-2 inhibitors. He and BYU felt that Pfizer had not properly credited or paid them for Simmons work in this development and brought a suit against Pfizer.

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Daniel L. Simmons's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression (2002) (1916)
Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. (1991) (1749)
Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition (2004) (1612)
Identification of a novel aspartic protease (Asp 2) as beta-secretase. (1999) (433)
Identification of a phorbol ester-repressible v-src-inducible gene. (1989) (338)
Mitogen‐inducible prostaglandin G/H synthase: A new target for nonsteroidal antiinflammatory drugs (1992) (318)
Hormonal regulation of messenger ribonucleic acid encoding a novel isoform of prostaglandin endoperoxide H synthase in rat preovulatory follicles. Induction in vivo and in vitro. (1992) (285)
Isolation of cDNA clones encoding the beta isozyme of human DNA topoisomerase II and localisation of the gene to chromosome 3p24. (1992) (233)
The cyclooxygenases (2004) (223)
Identification of an early-growth-response gene encoding a novel putative protein kinase (1992) (208)
Nonsteroidal antiinflammatory drugs cause apoptosis and induce cyclooxygenases in chicken embryo fibroblasts. (1995) (205)
Characterization and hormonal regulation of the promoter of the rat prostaglandin endoperoxide synthase 2 gene in granulosa cells. Identification of functional and protein-binding regions. (1993) (187)
Rel-associated pp40: an inhibitor of the rel family of transcription factors. (1991) (186)
Cis-acting sequences regulating expression of the human α-globin cluster lie within constitutively open chromatin (1992) (155)
Induction of an acetaminophen-sensitive cyclooxygenase with reduced sensitivity to nonsteroid antiinflammatory drugs. (1999) (154)
Prostaglandin G/H synthase isoenzyme 2 expression in fibroblasts: regulation by dexamethasone, mitogens, and oncogenes. (1993) (139)
Visual spatial memory is enhanced in female rats (but inhibited in males) by dietary soy phytoestrogens (2001) (136)
Structural determination and promoter analysis of the chicken mitogen-inducible prostaglandin G/H synthase gene and genetic mapping of the murine homolog. (1993) (128)
ASP1 (BACE2) Cleaves the Amyloid Precursor Protein at the β-Secretase Site (2000) (126)
Induction of the hepatic mixed-function oxidase system by synthetic glucocorticoids. Transcriptional and post-transcriptional regulation. (1987) (115)
Constitutive expression of a gene encoding a polypeptide homologous to biologically active human platelet protein in Rous sarcoma virus-transformed fibroblasts. (1987) (112)
Bacterial lipopolysaccharide-mediated fetal death. Production of a newly recognized form of inducible cyclooxygenase (COX-2) in murine decidua in response to lipopolysaccharide. (1995) (110)
Chromosomal assignments of genes coding for components of the mixed-function oxidase system in mice. Genetic localization of the cytochrome P-450PCN and P-450PB gene families and the nadph-cytochrome P-450 oxidoreductase and epoxide hydratase genes. (1985) (109)
Multiple Cyclooxygenases: Cloning of a Mitogen-Inducible Form (1991) (107)
The effect of the aged garlic extract, 'Kyolic', on the development of experimental atherosclerosis. (1997) (104)
Determination of expression of cyclooxygenase-1 and -2 isozymes in canine tissues and their differential sensitivity to nonsteroidal anti-inflammatory drugs. (2004) (89)
Interaction of cyclooxygenases with an apoptosis- and autoimmunity-associated protein. (1996) (86)
Nonsteroidal anti-inflammatory drugs, acetaminophen, cyclooxygenase 2, and fever. (2000) (82)
Cloning and expression of a chicken c-rel cDNA: unlike p59v-rel, p68c-rel is a cytoplasmic protein in chicken embryo fibroblasts. (1990) (71)
ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site. (2000) (69)
Variants of cyclooxygenase-1 and their roles in medicine. (2003) (62)
Rapid repression of quiescence-specific gene expression by epidermal growth factor, insulin, and pp60v-src (1989) (62)
Cyclooxygenase-3 Gene Expression in Alzheimer Hippocampus and in Stressed Human Neural Cells (2004) (59)
Trifunctional inhibition of COX-2 by extracts of Lonicera japonica: direct inhibition, transcriptional and post-transcriptional down regulation. (2007) (56)
Structure of the human 3-methyladenine DNA glycosylase gene and localization close to the 16p telomere. (1993) (55)
Quantitation of mRNAs specific for the mixed-function oxidase system in rat liver and extrahepatic tissues during development. (1989) (54)
Genetic polymorphisms for a phenobarbital-inducible cytochrome P-450 map to the Coh locus in mice. (1983) (54)
Cyclooxygenase-1 or -2--which one mediates lipopolysaccharide-induced hypothermia? (2009) (48)
COX-2 inhibition, apoptosis, and chemoprevention by nonsteroidal anti-inflammatory drugs. (2000) (37)
Human leukemia inhibitory factor inhibits development of experimental atherosclerosis. (1994) (36)
Cyclooxygenase variants: the role of alternative splicing. (2005) (34)
DP-155, a lecithin derivative of indomethacin, is a novel nonsteroidal antiinflammatory drug for analgesia and Alzheimer's disease therapy. (2007) (29)
Delayed DNA methylation is an integral feature of DNA replication in mammalian cells. (1986) (27)
Different patterns of developmental toxicity in the rat following prenatal administration of structurally diverse chemicals. (1984) (24)
NSAID-induced apoptosis in Rous sarcoma virus-transformed chicken embryo fibroblasts is dependent on v-src and c-myc and is inhibited by bcl-2. (1997) (24)
Regulation of hen granulosa cell prostaglandin production by transforming growth factors during follicular development: involvement of cyclooxygenase II. (1996) (22)
In vivo and in vitro expression of a non-mammalian cyclooxygenase-1. (1996) (21)
Drug inhibition and cellular regulation of prostaglandin G/H synthase isoenzyme 2. (1993) (15)
Phylogenetic Relationships of the Sceloporus scalaris Species Group (Squamata) (1997) (15)
BioID reveals an ATG9A interaction with ATG13‐ATG101 in the degradation of p62/SQSTM1‐ubiquitin clusters (2021) (12)
Comments on “Acetaminophen and the Cyclooxygenase-3 Puzzle: Sorting out Facts, Fictions, and Uncertainties” (2005) (11)
Answering the Burning Question of How Transient Receptor Potential Vanilloid-1 Channel Antagonists Cause Unwanted Hyperthermia (2009) (10)
Levels and stability of DNA methylation in random surviving cell clones derived from a Chinese hamster cell line after prolonged treatment with 5-aza-2'-deoxycytidine. (1986) (10)
The N-terminus of COX-1 and its effect on cyclooxygenase-1 catalytic activity. (2010) (7)
Molecular analyses of gene products associated with the response of cells to mitogenic stimulation. (1988) (7)
Sequence specificity of cytosine methylation in the DNA of the Chinese hamster ovary (CHO-K1) cell line. (1984) (6)
COX-2 and apoptosis: NSAIDs as effectors of programmed cell death (1998) (5)
Antipyretic therapy: clinical pharmacology. (2018) (5)
Role and regulation of prostaglandin synthesis in the mitogenic response of ovarian granulosa cells to transforming growth factor alpha. (1997) (4)
Localisation of cyclooxygenase-3 in rat central nervous system (2004) (3)
Expression of cyclooxygenase isoforms in the baculovirus expression system. (2010) (2)
Screening large numbers of recombinant plasmids： modifications and additions to alkaline lysis for greater efficiency (2006) (1)
The effect of short-term thermal stresses on the survival of nearshore copepods (1978) (0)
2.0. LITERATURE REVIEW 2.1. BACKGROUND INFORMATION AND BIOANALYTICAL ASSAY METHODS OVERVIEW OF DRUGS 2.1.1. Aceclofenac (2013) (0)
The dilemma of two cyclooxygenases: identifying the roles of COX-1 and COX-2 in inflammation and apoptosis (1996) (0)
C 88 Organisation of sensitisation of hind limb withdrawal reflexes during the development of acute antigen-induced inflammation in the anaesthetised rabbit (2004) (0)
Distribution of trace elements during retorting of eastern oil shales (1985) (0)
- Snk: Serum-inducible kinase (vertebrates) (1995) (0)
PC14 POSSIBLE ROLE FOR CYCLOOXYGENASE 3 IN HEADACHE (2004) (0)
Rous Sarcoma Virus Induces a New Form of Prostaglandin G/H Synthase (Cyclooxygenase) (1993) (0)
Accidental Child Poisonings. Aspirin and other Medicines, not Household Chemical Specialties, are the most Commonly Ingested Substances in Accidental Poisonings. (1960) (0)

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Daniel L. Simmons's Academic­Influence.com Rankings