Daniel Mansuy
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Biology
Daniel Mansuy's Degrees
- PhD Molecular Biology University of California, San Francisco
- Bachelors Biochemistry University of California, Berkeley
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(Suggest an Edit or Addition)Daniel Mansuy's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- JunD Reduces Tumor Angiogenesis by Protecting Cells from Oxidative Stress (2004) (558)
- Monooxygenase-like oxidation of hydrocarbons by hydrogen peroxide catalyzed by manganese porphyrins and imidazole: selection of the best catalytic system and nature of the active oxygen species (1988) (367)
- Activation of alkanes : the biomimetic approach (1993) (308)
- Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug. (1987) (299)
- Cytochrome P-450 and synthetic models (1987) (226)
- The great diversity of reactions catalyzed by cytochromes P450. (1998) (212)
- A brief history of the contribution of metalloporphyrin models to cytochrome P450 chemistry and oxidation catalysis (2007) (208)
- Structure of a substrate complex of mammalian cytochrome P450 2C5 at 2.3 A resolution: evidence for multiple substrate binding modes. (2003) (186)
- N omega-hydroxyl-L-arginine, an intermediate in the L-arginine to nitric oxide pathway, is a strong inhibitor of liver and macrophage arginase. (1994) (175)
- Interaction of cationic porphyrins with DNA: importance of the number and position of the charges and minimum structural requirements for intercalation. (1990) (174)
- Structure of mammalian cytochrome P450 2C5 complexed with diclofenac at 2.1 A resolution: evidence for an induced fit model of substrate binding. (2003) (171)
- Chemical model systems for drug-metabolizing cytochrome-P-450-dependent monooxygenases. (1989) (161)
- Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid. (1994) (160)
- Ferrocenyl quinone methides as strong antiproliferative agents: formation by metabolic and chemical oxidation of ferrocenyl phenols. (2009) (159)
- Ticlopidine as a selective mechanism-based inhibitor of human cytochrome P450 2C19. (2001) (158)
- Substrate Specificity of NO Synthases: Detailed Comparison of l-Arginine, Homo-l-arginine, Their Nω-Hydroxy Derivatives, and Nω-Hydroxynor-l-arginine† (1998) (154)
- Iron- and manganese-porphyrin catalysed aziridination of alkenes by tosyl- and acyl-iminoiodobenzene (1984) (151)
- Highly oxidation resistant inorganic-porphyrin analog polyoxometalate oxidation catalysts. 2. Catalysis of olefin epoxidation and aliphatic and aromatic hydroxylations starting from .alpha.2-P2W17O61(Mn+.cntdot.Br)(n-11) (Mn+ = Mn3+,Fe3+,Co2+,Ni2+,Cu2+), including quantitative comparisons to metallo (1991) (146)
- Effects of the new arginase inhibitor N(omega)-hydroxy-nor-L-arginine on NO synthase activity in murine macrophages. (1999) (141)
- Biomimetic catalysts for selective oxidation in organic chemistry (1990) (135)
- Interaction of sulfaphenazole derivatives with human liver cytochromes P450 2C: molecular origin of the specific inhibitory effects of sulfaphenazole on CYP 2C9 and consequences for the substrate binding site topology of CYP 2C9. (1996) (122)
- Evidence for phosgene formation during liver microsomal oxidation of chloroform. (1977) (116)
- Cytochrome P450 catalyzes the oxidation of N omega-hydroxy-L-arginine by NADPH and O2 to nitric oxide and citrulline. (1992) (115)
- The substrate binding site of human liver cytochrome P450 2C9: an approach using designed tienilic acid derivatives and molecular modeling. (1995) (115)
- Formation of nitrogen oxides and citrulline upon oxidation of N omega-hydroxy-L-arginine by hemeproteins. (1992) (113)
- Cytochromes P450 catalyze both steps of the major pathway of clopidogrel bioactivation, whereas paraoxonase catalyzes the formation of a minor thiol metabolite isomer. (2012) (113)
- Dual effects of macrolide antibiotics on rat liver cytochrome P-450. Induction and formation of metabolite-complexes: a structure-activity relationship. (1983) (107)
- Specificity of in vitro covalent binding of tienilic acid metabolites to human liver microsomes in relationship to the type of hepatotoxicity: comparison with two directly hepatotoxic drugs. (1994) (107)
- Nitric oxide formation during microsomal hepatic denitration of glyceryl trinitrate: involvement of cytochrome P-450. (1989) (107)
- Particular ability of cytochromes P450 3A to form inhibitory P450-iron-metabolite complexes upon metabolic oxidation of aminodrugs. (1995) (105)
- Alkane hydroxylation catalyzed by metalloporhyrins : evidence for different active oxygen species with alkylhydroperoxides and iodosobenzene as oxidants. (1982) (102)
- Self-induction by triacetyloleandomycin of its own transformation into a metabolite forming a stable 456 nm-absorbing complex with cytochrome P-450. (1981) (101)
- The reduction of polyhalogenated methanes by liver microsomal cytochrome P450. (1977) (101)
- Manganese Porphyrins Adsorbed or Intercalated in Different Mineral Matrices: Preparation and Compared Properties as Catalysts for Alkene and Alkane Oxidation (1992) (101)
- Particular ability of liver P450s3A to catalyze the oxidation of N omega-hydroxyarginine to citrulline and nitrogen oxides and occurrence in no synthases of a sequence very similar to the heme-binding sequence in P450s. (1993) (95)
- Preparation of functionalized polyhalogenated tetraaryl-porphyrins by selective substitution of the p-Fluorines of meso-tetra-(pentafluorophenyl)porphyrins (1991) (93)
- Metabolic oxidative cleavage of thioesters: evidence for the formation of sulfenic acid intermediates in the bioactivation of the antithrombotic prodrugs ticlopidine and clopidogrel. (2009) (90)
- New iron-porphyrin complexes with metal-carbon bond - biological implications (1980) (88)
- Allylic amination of alkenes by tosyliminoiodobenzene: manganese porphyrins as suitable catalysts (1988) (88)
- Substrate selectivity of human cytochrome P450 2C9: importance of residues 476, 365, and 114 in recognition of diclofenac and sulfaphenazole and in mechanism-based inactivation by tienilic acid. (2003) (88)
- A very efficient system for alkene epoxidation by hydrogen peroxide: catalysis by manganese-porphyrins in the presence of imidazole (1985) (87)
- Expression of human liver cytochrome P450 IIIA4 in yeast. A functional model for the hepatic enzyme. (1990) (87)
- Optimization of yeast-expressed human liver cytochrome P450 3A4 catalytic activities by coexpressing NADPH-cytochrome P450 reductase and cytochrome b5. (1992) (84)
- Interaction of cis-diaquodiammineplatinum dinitrate with ribose dinucleoside monophosphates (1980) (83)
- Substrate specificity of NO synthases: detailed comparison of L-arginine, homo-L-arginine, their N omega-hydroxy derivatives, and N omega-hydroxynor-L-arginine. (1998) (83)
- Thiophene S-oxides as new reactive metabolites: formation by cytochrome P-450 dependent oxidation and reaction with nucleophiles (1991) (82)
- Human-liver cytochromes P-450 expressed in yeast as tools for reactive-metabolite formation studies. Oxidative activation of tienilic acid by cytochromes P-450 2C9 and 2C10. (1993) (82)
- Manganese porphyrins covalently bound to silica and montmorillonite K10 as efficient catalysts for alkene and alkane oxidation by hydrogen peroxide (1996) (81)
- Chemical and Biological Oxidation of Thiophene: Preparation and Complete Characterization of Thiophene S-Oxide Dimers and Evidence for Thiophene S-Oxide as an Intermediate in Thiophene Metabolism in Vivo and in Vitro (1997) (81)
- Ellipticines as potent inhibitors of aryl hydrocarbon hydroxylase: their binding to microsomal cytochromes P450 and protective effect against benzo(a)pyrene mutagenicity. (1978) (79)
- First evidence that cytochrome P450 may catalyze both S-oxidation and epoxidation of thiophene derivatives. (2005) (79)
- Microsomal cytochrome P450 dependent oxidation of N-hydroxyguanidines, amidoximes, and ketoximes: mechanism of the oxidative cleavage of their C=N(OH) bond with formation of nitrogen oxides. (1998) (79)
- Nitrosoalkanes as Fe(II) ligands in the 455-nm-absorbing cytochrome P-450 complexes formed from nitroalkanes in reducing conditions. (1977) (79)
- Monooxygenase-like oxidations of olefins and alkanes catalyzed by manganese porphyrins : comparison of systems involving either O2 and ascorbate or iodosylbenzene (1984) (77)
- Metalloporphyrinosilicas: a new class of hybrid organic–inorganic materials acting as selective biomimetic oxidation catalysts (1996) (77)
- Oxidation of Cyclohexane by Molecular Oxygen Photoassisted by meso-Tetraarylporphyrin Iron(III)-Hydroxo Complexes. (1996) (76)
- Polymeric polyhalogenated metalloporphyrin catalysts for hydroxylation of alkanes and epoxidation of alkenes (1991) (76)
- Hydroxylation and formation of electrophilic metabolites of tienilic acid and its isomer by human liver microsomes. Catalysis by a cytochrome P450 IIC different from that responsible for mephenytoin hydroxylation. (1991) (75)
- The new alpha-amino acid N-omega-hydroxy-nor-L-arginine: A high-affinity inhibitor of arginase well adapted to bind to its manganese cluster (1997) (75)
- A class of strong inhibitors of microsomal monooxygenases: the ellipticines. (1979) (74)
- Thiophene sulfoxides as reactive metabolites: formation upon microsomal oxidation of a 3-aroylthiophene and fate in the presence of nucleophiles in vitro and in vivo. (1996) (74)
- A new potent inhibitor of lipid peroxidation in vitro and in vivo, the hepatoprotective drug anisyldithiolthione. (1986) (73)
- Autoantibodies against cytochromes P450: role in human diseases. (1994) (73)
- Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs. (1999) (73)
- Preparation of a porphyrin-iron-carbene model for the cytochrome P 450 complexes obtained upon metabolic oxidation of the insecticide synergists of the 1,3-benzodioxole series (1979) (73)
- Spectroscopic Characterization of an FeIV Intermediate Generated by Reaction of XO− (X = Cl, Br) with an FeII Complex Bearing a Pentadentate Non-Porphyrinic Ligand − Hydroxylation and Epoxidation Activity (2004) (72)
- Aziridination of alkenes catalysed by porphyrinirons: selection of catalysts for optimal efficiency and stereospecificity (1988) (72)
- Formation of a complex with a carbide bridge between two iron atoms from the reaction of (tetraphenylporphyrin)iron(II) with carbon tetraiodide (1981) (72)
- Metabolism of polychlorinated phenols by Pseudomonas cepacia AC1100: determination of the first two steps and specific inhibitory effect of methimazole (1995) (71)
- Mechanistic and metabolic inferences from the binding of substrate analogues and products to arginase. (2001) (71)
- The nature of the "455 nm absorbing complex" formed during the cytochrome P450 dependent oxidative metabolism of amphetamine. (1976) (69)
- Hydroxylation of linear alkanes catalysed by iron porphyrins: particular efficacy and regioselectivity of perhalogenated porphyrins (1991) (69)
- Paraoxonase-1 and clopidogrel efficacy (2011) (68)
- Hypoactivity of cytochrome P-450 after triacetyloleandomycin administration. (1981) (67)
- Antigenic targets in tienilic acid hepatitis. Both cytochrome P450 2C11 and 2C11-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera. (1996) (67)
- Evidence for thiophene-S-oxide as a primary reactive metabolite of thiophene in vivo: formation of a dihydrothiophene sulfoxide mercapturic acid. (1992) (67)
- Deciphering the activation sequence of ferrociphenol anticancer drug candidates. (2012) (66)
- Dichlorocarbene Complexes of Iron(II)‐Porphyrins–Crystal and Molecular Structure of Fe(TPP)(CCl2)(H2O) (1978) (65)
- Dehydration of alkyl- and arylaldoximes as a new cytochrome P450-catalyzed reaction: mechanism and stereochemical characteristics. (1994) (64)
- Synthesis and Catalytic Properties of Manganese Porphyrins Incorporated into Phosphonate Networks (1995) (64)
- Iron porphyrin-catalyzed oxidation of 1,2-dimethoxyarenes : a discussion of the different reactions involved and the competition between the formation of methoxyquinones or muconic dimethyl esters (1993) (63)
- 5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazol-2(3H)-one derivatives and related analogues: new reversible, highly potent, and selective monamine oxidase type B inhibitors. (1993) (62)
- Mono-oxygenase-like oxidation of hydrocarbons using supported manganese–porpnyrin catalysts: beneficial effects of a silica support for alkane hydroxylation (1989) (61)
- Mechanisms of inactivation of lipoxygenases by phenidone and BW755C. (1991) (60)
- Manganese porphyrins supported on montmorillonite as hydrocarbon mono-oxygenation catalysts: particular efficacy for linear alkane hydroxylation (1990) (59)
- High affinity of ergopeptides for cytochromes P450 3A. Importance of their peptide moiety for P450 recognition and hydroxylation of bromocriptine. (1994) (59)
- Biomimetic hydroxylation of aromatic compounds: Hydrogen peroxide and manganese-polyhalogenated porphyrins as a particularly good system. (1992) (59)
- Formation of nitric oxide by cytochrome P450-catalyzed oxidation of aromatic amidoximes. (1992) (58)
- Formation of an iron(III)-porphyrin complex with a nitrene moiety inserted into an iron-nitrogen bond during alkene aziridination by (tosylimidoiodo)benzene catalyzed by iron(III) porphyrins (1986) (57)
- Asymmetric epoxidation of alkenes catalysed by a basket-handlë iron-porphyrin bearing amino acids (1985) (57)
- Unusual regioselectivity and active site topology of human cytochrome P450 2J2. (2007) (56)
- The substrate binding site of human liver cytochrome P450 2C9: an NMR study. (1997) (56)
- Inhibitor coordination interactions in the binuclear manganese cluster of arginase. (2004) (55)
- Structure-activity relationships for DNA photocleavage by cationic porphyrins. (1993) (55)
- Nitrosoalkane complexes of iron-porphyrins: analogy between the bonding properties of nitrosoalkanes and dioxygen (1983) (55)
- New Catalytic Properties of Iron Porphyrins: Model Systems for Cytochrome P450-Catalyzed Dehydration of Aldoximes (1998) (55)
- The New α-Amino Acid Nω-Hydroxy-nor-L-arginine: A High- Affinity Inhibitor of Arginase Well Adapted to Bind to Its Manganese Cluster. (1997) (55)
- Amination of alkanes catalyzed by iron- and manganese-porphyrins: particular selectivity for ω and ω−1 oxidations of linear alkanes (1990) (54)
- Partial purification of human liver cytochrome P 450. (1979) (54)
- Oxidative metabolism of linoleic acid by human leukocytes. (1989) (54)
- Oxidation of tienilic acid by human yeast-expressed cytochromes P-450 2C8, 2C9, 2C18 and 2C19. Evidence that this drug is a mechanism-based inhibitor specific for cytochrome P-450 2C9. (1996) (54)
- Oxidative activation of the thiophene ring by hepatic enzymes. Hydroxylation and formation of electrophilic metabolites during metabolism of tienilic acid and its isomer by rat liver microsomes. (1990) (53)
- Mono-oxigenase-like dioxygen activation leading to alkane hydroxylation and olefin epoxidation by an MnIII(porphyrin)–ascorbate biphasic system (1983) (53)
- Thermodynamic studies of substrate binding and spin transitions in human cytochrome P-450 3A4 expressed in yeast microsomes. (1996) (53)
- Ammonium acetate as a very simple and efficient cocatalyst for manganese porphyrin-catalysed oxygenation of hydrocarbons by hydrogen peroxide (1994) (53)
- On the mechanism of nitric oxide formation upon oxidative cleavage of C = N(OH) bonds by NO-synthases and cytochromes P450. (1995) (52)
- Cytochromes P450 and flavin monooxygenases--targets and sources of nitric oxide. (2001) (52)
- Opposite behaviors of reactive metabolites of tienilic acid and its isomer toward liver proteins: use of specific anti-tienilic acid-protein adduct antibodies and the possible relationship with different hepatotoxic effects of the two compounds. (1999) (52)
- Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site-directed mutants. (2004) (51)
- Reaction of carbon tetrachloride with 5,10,15,20-tetraphenyl-porphinatoiron(II)[(TPP)FeII]: evidence for the formation of the carbene complex [(TPP)FeII(CCl2)] (1977) (51)
- Phororedox and photocatalytic processes on Fe(III)–porphyrin surface modified nanocrystalline TiO2 (2000) (51)
- An iron(III)-porphyrin complex with a vinylidene group inserted into an iron-nitrogen bond: relevance to the structure of the active oxygen complex of catalase (1981) (50)
- Selective, competitive and mechanism-based inhibitors of human cytochrome P450 2J2. (2007) (49)
- Hydroxylation of alkanes by hydrogen peroxide: and efficient system using manganese porphyrins and imidazole as catalysts (1986) (48)
- Photoredox and photocatalytic characteristics of various iron meso-tetraarylporphyrins (1991) (47)
- New manganese β-polynitroporphyrins as particularly efficient catalysts for biomimetic hydroxylation of aromatic compounds with H2O2 (2000) (47)
- Non-heme iron polyazadentate complexes as catalysts for oxidations by H2O2: particular efficiency in aromatic hydroxylations and beneficial effects of a reducing agent (2004) (46)
- Design and synthesis of selective, high-affinity inhibitors of human cytochrome P450 2J2. (2006) (46)
- Soybean lipoxygenase-catalyzed oxidations by linoleic acid hydroperoxide: different reducing substrates and dehydrogenation of phenidone and BW 755C. (1988) (46)
- N-Aryl N'-hydroxyguanidines, a new class of NO-donors after selective oxidation by nitric oxide synthases: structure-activity relationship. (2002) (46)
- A new and efficient biomimetic system for hydrocarbon oxidation by dioxygen using manganese porphyrins, imidazole, and zinc (1987) (45)
- Iron porphyrin-nitrene complexes: preparation from 1,1-dialkylhydrazines. Electronic structure from NMR, Moessbauer, and magnetic susceptibility studies and crystal structure of the [tetrakis(p-chlorophenyl)porphyrinato][(2,2,6,6-tetramethyl-1-piperidyl)nitrene]iron complex (1984) (45)
- Thiophene 1-oxides. V. Comparison of the crystal structures and thiophene ring aromaticity of 2,5-diphenylthiophene, its sulfoxide and sulfone†‡§¶ (1997) (45)
- Non-heme iron polyazadentate complexes as catalysts for aromatic hydroxylation by H2O2: Particular efficiency of tetrakis(2-pyridylmethyl)ethylenediamine–iron(II) complexes (2008) (45)
- Recombinant yeast in drug metabolism. (1993) (45)
- Recognition of alpha-amino acids bearing various C=NOH functions by nitric oxide synthase and arginase involves very different structural determinants. (2000) (44)
- Molecular structure and hepatotoxicity: compared data about two closely related thiophene compounds. (1997) (44)
- Nitrosoalkanes as Fe(II) ligands in the hemoglobin and myoglobin complexes formed from nitroalkanes in reducing conditions. (1977) (44)
- Drug-induced immunotoxicity (1998) (43)
- Alternative nitric oxide-producing substrates for NO synthases. (2004) (43)
- Cytochromes P-450 and model systems: great diversity of catalyzed reactions (1994) (43)
- In the presence of imidazole, iron-and manganese-porphyrins catalyse the epoxidation of alkenes by alkyl hydroperoxides (1984) (42)
- Formation of complexes between microsomal cytochrome P-450-Fe(II) and nitrosoarenes obtained by oxidation of arylhydroxylamines or reduction of nitroarenes in situ. (1978) (42)
- Sulfenic acids as reactive intermediates in xenobiotic metabolism. (2011) (41)
- Synthesis and remarkable properties of iron β-polynitroporphyrins as catalysts for monooxygenation reactions (1994) (41)
- Metalloporphyrin‐Catalyzed Hydroxylation of Cyclohexane by Alkyl Hydroperoxides: Pronounced Efficiency of Iron‐Porphyrins (1980) (41)
- An easy access to polyhalogenated metalloporphyrins covalently bound to polymeric supports as efficient catalysts for hydrocarbon oxidation (1992) (40)
- Mode of interaction and apparent binding constants of meso-tetraaryl porphyrins bearing between one and four positive charges with DNA. (1986) (40)
- Nω-Hydroxyamino-α-amino acids as a new class of very strong inhibitors of arginases (1996) (40)
- The stimulatory effects of asbestos on NADPH-dependent lipid peroxidation in rat liver microsomes. (1987) (40)
- Metabolic hydroxylation of the thiophene ring: isolation of 5-hydroxy-tienilic acid as the major urinary metabolite of tienilic acid in man and rat. (1984) (39)
- Regioselectivity of olefin oxidation by iodosobenzene catalyzed by metalloporphyrins : control by the catalyst (1984) (39)
- Isolation of an iron-nitrene complex from the dioxygen- and iron porphyrin-dependent oxidation of a hydrazine (1982) (39)
- Artificial peroxidase‐like hemoproteins based on antibodies constructed from a specifically designed ortho‐carboxy substituted tetraarylporphyrin hapten and exhibiting a high affinity for iron‐porphyrins (1996) (39)
- Chaperone-assisted expression, purification, and characterization of recombinant nitrile hydratase NI1 from Comamonas testosteroni. (2003) (39)
- A biomimetic electrochemical system for the oxidation of hydrocarbons by dioxygen catalyzed by manganese-porphyrins and imidazole. (1988) (39)
- Reductive electrochemistry of iron-carbene porphyrins (1983) (38)
- Iron-porphyrin-nitrene complexes: preparation, properties, and crystal structure of porphyrin-iron(III) complexes with a tosylnitrene inserted into an iron-nitrogen bond (1988) (38)
- In vivo and in vitro effects of a new macrolide antibiotic roxithromycin on rat liver cytochrome P-450: comparison with troleandomycin and erythromycin. (1988) (38)
- Reversible iron-nitrogen migration of alkyl, aryl, or vinyl groups in iron porphyrins: a possible passage between .sigma. FeIII(porphyrin)(R) and FeII(N-R)(porphyrin)complexes (1982) (37)
- New Metalloporphyrins with Extremely Altered Redox Properties: Synthesis, Structure, and Facile Reduction to Air-Stable π-Anion Radicals of Zinc and Nickel β-Heptanitroporphyrins (1997) (37)
- Highly efficient control of iron‐containing nitrile hydratases by stoichiometric amounts of nitric oxide and light (1997) (37)
- Particular ability of cytochrome P-450 CYP3A to reduce glyceryl trinitrate in rat liver microsomes: subsequent formation of nitric oxide. (1993) (37)
- Interaction of aliphatic N-hydroxylamines with microsomal cytochrome P450: nature of the different derived complexes and inhibitory effects on monoxygenases activities. (1978) (37)
- Ellipticines as potent inhibitors of microsomes-dependent chemical mutagenesis. (1979) (36)
- Reactivity of polyhalogenated and zeolite-encapsulated metalloporphyrins in oxidation with dioxygen (1996) (36)
- Photocatalytic oxidation of cyclohexane by (nBu4N)4W10O32Fe(III)prophyrins integrated systems (1996) (36)
- Reduction of nilutamide by NO synthases: implications for the adverse effects of this nitroaromatic antiandrogen drug. (2003) (35)
- Thiophene S-oxides: convenient preparation, first complete structural characterization and unexpected dimerization of one of them, 2,5-diphenylthiophene-1-oxide (1995) (35)
- Phenylhydrazones as new good substrates for the dioxygenase and peroxidase reactions of prostaglandin synthase: formation of iron(III)-sigma-phenyl complexes. (1993) (35)
- Formation of a ferric carbanion complex from halothane and cytochrome P-450: electron spin resonance, electronic spectra, and model complexes (1984) (35)
- Formation of nitrogen oxides including NO from oxidative cleavage of CN(OH) bonds: A general cytochrome P450-dependent reaction. (1995) (35)
- Oxidation of monosubstituted olefins by cytochromes P-450 and heme models: evidence for the formation of aldehydes in addition to epoxides and allylic alcohols. (1984) (34)
- Nitrosoalkanes as new ligands of iron(II) porphyrins and hemoproteins. (1977) (34)
- Interactions of DNA with a new electron-deficient tentacle porphyrin: meso-tetrakis[2,3,5,6-tetrafluoro-4-(2-t rimethylammoniumethyl-amine)phenyl]porphy rin. (1997) (34)
- Strong inhibition of neuronal nitric oxide synthase by the calmodulin antagonist and anti-estrogen drug tamoxifen. (1997) (33)
- Microperoxidase 8 catalyzed nitration of phenol by nitrogen dioxide radicals. (2001) (33)
- OXIDATION OF N-HYDROXYGUANIDINES BY CYTOCHROMES P450 AND NO-SYNTHASES AND FORMATION OF NITRIC OXIDE (2002) (32)
- Metabolic stability of superoxide adducts derived from newly developed cyclic nitrone spin traps. (2014) (32)
- Involvement of NO in the Endothelium-Independent Relaxing Effects of N ω-Hydroxy-l-arginine and Other Compounds Bearing a C=NOH Function in the Rat Aorta (2002) (32)
- Formation and fate of a sulfenic acid intermediate in the metabolic activation of the antithrombotic prodrug prasugrel. (2010) (32)
- Formation and fate of iron-carbene complexes in reactions between a diazoalkane and iron-porphyrins: relevance to the mechanism of formation of N-substituted hemes in cytochrome P-450-dependent oxidation of sydnones (1990) (32)
- The cytochrome P-450 metabolite complex derived from troleandomycin: properties in vitro and stability in vivo. (1984) (32)
- Reaction of 2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane (DDT) with iron(II) porphyrins. Isolation of the vinylidene carbene complex, tetraphenylporphyriniron(II) (C:C(p-Cl-C6H4)2) (1978) (32)
- Superoxide anion efficiently performs the oxidative cleavage of CNOH bonds of amidoximes and N-hydroxyguanidines with formation of nitrogen oxides (1995) (31)
- Reaction of monosubstituted hydrazines and diazenes with rat-liver cytochrome P450. Formation of ferrous-diazene and ferric sigma-alkyl complexes. (1983) (31)
- Mechanism of the aromatic hydroxylation of thiophene by acid-catalyzed peracid oxidation. (2002) (31)
- Oxidation of alkanes by dioxygen catalysed by photoactivated iron porphyrins (1991) (30)
- Selective Oxygenation of Hydrocarbons and Sulfoxidation of Thioethers by Dioxygen with a Mn-Porphyrin-Based Cytochrome P450 Model System Using Zn as Electron Donor. (2010) (30)
- Peroxidase-like activity of lipoxygenases: different substrate specificity of potato 5-lipoxygenase and soybean 15-lipoxygenase and particular affinity of vitamin E derivatives for the 5-lipoxygenase. (1991) (29)
- Ferrocenyl Quinone Methide-Thiol Adducts as New Antiproliferative Agents: Synthesis, Metabolic Formation from Ferrociphenols, and Oxidative Transformation. (2016) (29)
- Biotransformation of chloroform by rat and human liver microsomes; in vitro effect on some enzyme activities and mechanism of irreversible binding to macromolecules. (1979) (29)
- Iron polynitroporphyrins bearing up to eight beta-nitro groups as interesting new catalysts for H2O2-dependent hydrocarbon oxidation: unusual regioselectivity in hydroxylation of alkoxybenzenes. (2001) (29)
- Phosphines as ligands to microsomal cytochrome P-450. (1974) (29)
- Anti‐cytochrome P450 autoantibodies in drug‐induced disease (1996) (29)
- A new generation of ferrociphenols leads to a great diversity of reactive metabolites, and exhibits remarkable antiproliferative properties (2017) (29)
- Iron porphyrin dependent oxidation of methyl- and phenylhydrazine: isolation of iron(II)-diazene and .sigma.-alkyliron(III) [or aryliron(III)] complexes. Relevance to the reactions of hemoproteins with hydrazines (1983) (29)
- Structure-activity relationships in the inhibitory effects of ellipticines on benzo(a)pyrene hydroxylase activity and 3-methylcholanthrene mutagenicity. (1980) (28)
- OXIDATION OF N-HETEROCYCLES BY H2O2 CATALYZED BY A MN-PORPHYRIN: AN EASY ACCESS TO N-OXIDES UNDER MILD CONDITIONS (1997) (28)
- Heme model studies related to cytochrome P-450 reactions: preparation of iron porphyrin complexes with carbenes bearing a .beta.-oxygen atom and their transformation into iron-N-alkylporphyrins and iron-metallacyclic complexes (1988) (28)
- Synthesis and evaluation of new ω-borono-α-amino acids as rat liver arginase inhibitors (2005) (28)
- Oxidative and reductive metabolism of tris(p-carboxyltetrathiaaryl)methyl radicals by liver microsomes. (2009) (28)
- Oxidative Metabolism of Ferrocene Analogues of Tamoxifen: Characterization and Antiproliferative Activities of the Metabolites (2015) (28)
- Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450. (2003) (27)
- Reduction of the Fe(III)-tyrosyl radical center of Escherichia coli ribonucleotide reductase by dithiothreitol. (1990) (27)
- Hydroxylation of the thiophene ring by hepatic monooxygenases. Evidence for 5-hydroxylation of 2-aroylthiophenes as a general metabolic pathway using a simple UV-visible assay. (1990) (27)
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- NITROSOALKANES AS NEW LIGANDS OF IRON(II) PORPHYRINS AND HEMOPROTEINS (1977) (2)
- Thiophene S-Oxides: Convenient Preparation, First Complete Structural Characterization and Unexpected Dimerization of One of Them, 2,5- Diphenylthiophene-1-oxide. (2010) (2)
- Hydroxylation of leukotriene B4 in leukocytes from various species: identification of a metabolite to authentic 5S,12R,19-trihydroxy-6Z,8E,10E,14Z-eicosatetra enoic acid and relative importance of 19- and 20-hydroxylations. (1989) (2)
- Oxidation of N(omega)-hydroxyarginine analogues by NO-synthase: the simple, non amino acid N-butyl N'-hydroxyguanidine is almost as efficient an NO precursor as N(omega)-hydroxyarginine. (2001) (2)
- Surface Active Sites and Catalytic Properties of Asbestos Mineral. Possible Consequence for their Activity in Biological Medium (1985) (2)
- Comparison of wild type neuronal nitric oxide synthase and its Tyr588Phe mutant towards various L-arginine analogues. (2010) (2)
- INHmITION BY TICLOPIDINE AND ITS DERIVATIVES OF HUMAN LIVER CYTOCHROME P 450 . MECHANISM-BASED INACTIVATION OF CYP 2 C 19 BY TICLOPIDINE (2)
- New Recognition Elements in Biosensing (1998) (2)
- An Easy Access to Polyhalogenated Metalloporphyrins Covalently Bound to Polymeric Supports as Efficient Catalysts for Hydrocarbon Oxidation. (1992) (2)
- IRON PORPHYRIN DEPENDENT OXIDATION OF METHYL‐ AND PHENYLHYDRAZINE: ISOLATION OF IRON(II)‐DIAZENE AND Σ‐ALKYLIRON(III) (OR ARYLIRON(III)) COMPLEXES. RELEVANCE TO THE REACTIONS OF HEMOPROTEINS WITH HYDRAZINES (2002) (2)
- 3 Interaction of cis-[Pt(NH3)2Cl2] and cis-[Pt(NH3)2(H2O2)2]2+ 2 NO3− with 3′5-diinosine phosphate (I3′p5′I) and 3′5′-diadenosine phosphate (A3′p5′A) (1978) (2)
- Cytochromes P450 and drug toxicity (1995) (2)
- Reactive Intermediates Derived from Cytochrome P-450 Monooxygenases (1983) (1)
- Hydroxylation of Linear Alkanes Catalyzed by Iron Porphyrins: Particular Efficacy and Regioselectivity of Perhalogenated Porphyrins. (1991) (1)
- Immunostimulating lipopeptide, LtriP (RP 56142): Comparison of the effect on hepatic cytochrome P 450 modulation and radioprotection in male and female of three mouse strains (1995) (1)
- Microperoxidase 8 (mp8) as a convenient model for hemoproteins: formation and characterisation of new iron(II)-nitrosoalkane complexes of biological relevance. (2001) (1)
- On the Investigation by EXAFS Spectroscopy of a Selenocarbonyl Complex (CSe = Fe(II)TPP) (1983) (1)
- A new resonance Raman band characteristic of pentaco-ordination in iron tetraphenylporphyrin complexes (1980) (1)
- A New General Method for Selective β-Polynitration of Porphyrins; Preparation and Redox Properties of Zn-Porphyrins Bearing One Through to Eight β-Nitro Substituents and X-Ray Structure of the First Zn β-Pernitro Porphyrin. (2001) (1)
- Structural Investigations of Biomimetic Complexes of Cytochrome P-450 by Difference EXAFS Spectroscopy (1987) (1)
- Unstability of cinnabarinic acid, an endogenous metabolite of tryptophan, under situations mimicking physiological conditions. (2022) (1)
- Iron Polynitroporphyrins Bearing up to Eight β‐Nitro Groups as Interesting New Catalysts for H2O2‐Dependent Hydrocarbon Oxidation: Unusual Regioselectivity in Hydroxylation of Alkoxybenzenes. (2002) (1)
- Inhibition by pesticides of the DJ-1/Park7 protein related to Parkinson disease. (2023) (1)
- Critical role of Val567 in substrate recognition by neuronal nitric oxide synthase for NO formation activity (2003) (1)
- N-SUBSTITUTED PORPHYRIN FORMATION FROM CARBENE IRON-PORPHYRIN COMPLEXES : A POSSIBLE PATHWAY FOR CYTOCHROME P450 HEME DESTRUCTION (1981) (1)
- REVERSIBLE IRON-NITROGEN MIGRATION OF ALKYL, ARYL, OR VINYL GROUPS IN IRON PORPHYRINS: A POSSIBLE PASSAGE BETWEEN Σ FEIII(PORPHYRIN)(R) AND FEII(N-R)(PORPHYRIN)COMPLEXES (1983) (1)
- Oxidation of N-Heterocycles by H2O2 Catalyzed by a Mn-Porphyrin: An Easy Access to N-Oxides under Mild Conditions. (1998) (1)
- IRON PORPHYRIN-NITRENE COMPLEXES: PREPARATION FROM 1,1-DIALKYLHYDRAZINES. ELECTRONIC STRUCTURE FROM NMR, MOESSBAUER, AND MAGNETIC SUSCEPTIBILITY STUDIES AND CRYSTAL STRUCTURE OF THE (TETRAKIS(P-CHLOROPHENYL)PORPHYRINATO)((2,2,6,6-TETR (1984) (1)
- Metalloporphyrinosilicas: A New Class of Hybrid Organic-Inorganic Materials Acting as Selective Biomimetic Oxidation Catalysts (1997) (1)
- Inside Back Cover: Ferrocenyl Quinone Methide–Thiol Adducts as New Antiproliferative Agents: Synthesis, Metabolic Formation from Ferrociphenols, and Oxidative Transformation (Angew. Chem. Int. Ed. 35/2016) (2016) (1)
- Reactions de substitution des sels d'alkoxy-4 pyridinium (1976) (1)
- Synthesis of (4-Chlorophenyl)-(1-oxo-1λ4-benzo [b]thien-2-yl)methanone and Study of Its Reactivity Towards Sulfur- and Oxygen-Containing Nucleophiles. (1999) (1)
- Cytochrome P450 2U1, a very peculiar member of the human P450s family (2017) (0)
- Reaction of a Carbon Equivalent of Iodosylbenzene with Iron-Porphyrins: A Ready Access to N-Alkylporphyrin Complexes Involving Five-Membered cyclic Fe-O-C-C-N Metallocycles. (1987) (0)
- DICHLOROCARBENE(MESO-TETRAPHENYLPORPHYRINATO)IRON(II)COMPLEXES. CRYSTAL AND MOLECULAR STRUCTURE OF FE(TPP)(CCL2)(H2O) (1979) (0)
- Medicines at base of new derivatives 1h-4,1,2-benzoxadiazine derivatives and their processes of preparation (1989) (0)
- Demetallization of hydrocarbon petroleum cuts and use. (2006) (0)
- PSEUDO-SUICIDE INHIBITION AND INDUCTION OF CYTOCHROME P-450 (1986) (0)
- OXIDATION OF CAMPHENE BY TERT-BUTYL PERBENZOATE CATALYZED BY COPPER SALTS. SYNTHESIS OF NOJIGIKU ALCOHOL (1976) (0)
- SYNTHESIS OF PENTOS-3-ULOSE DERIVATIVES BRANCHED AT CARBON-2. CHEMICAL AND ENZYMIC EPOXIDATION OF 2-DEOXY-4,5-O-ISOPROPYLIDENE-2-C-METHYLENE-D-GLYCERO-PENTOS-3-ULOSE DIETHYL ACETAL (1984) (0)
- Oxidation of Cyclohexane Catalyzed by Polyhalogenated and Perhalogenated Iron Porphyrins (1993) (0)
- REACTION OF 2,2-BIS(P-CHLOROPHENYL)-1,1,1-TRICHLOROETHANE (DDT) WITH IRON(II) PORPHYRINS. ISOLATION OF THE VINYLIDENE CARBENE COMPLEX, TETRAPHENYLPORPHYRINIRON(II) (C-C(P-CL-C6H4)2) (1978) (0)
- Ammonium Acetate as a Very Simple and Efficient Cocatalyst for Manganese Porphyrin‐Catalyzed Oxygenation of Hydrocarbons by Hydrogen Peroxide. (1994) (0)
- Suicidal Inactivation of Iron Porphyrin Catalysts During Alk‐1‐ene Oxidation: Isolation of a New Type of N‐Alkylporphyrins. (1987) (0)
- TRANS‐BONDING BIDENTATE MACROLIGANDS IN PLATINUM(II) COMPLEXES (1974) (0)
- CCDC 736718: Experimental Crystal Structure Determination (2010) (0)
- Nature of the Complexes Derived from the Reaction of 1,1-Bis(p-chlorophenyl)-2,2,2-trichloroethane (DDT) with Iron Porphyrins: Crystal and Molecular Structure of the Vinylidene Carbene Complex Fe(TPP)(C=C(p-ClC6H4)2). (1988) (0)
- [Nobel Prize in Chemistry, 2005. Yves Chauvin, Robert H. Grubbs and Richard R. Schrock. Metathesis and catalysis honored]. (2005) (0)
- New Manganese β‐Polynitroporphyrins as Particularly Efficient Catalysts for Biomimetic Hydroxylation of Aromatic Compounds with H2O2. (2000) (0)
- Rapid synthesis of radiolabeled porphyrin complexes for medical application (1989) (0)
- The Chemistry of N-Alkylporphyrin Complexes: A Comparison of Reactivities and Structures of Chlorozinc(II) Complexes of N-Benzyl-, N-Methyl-, and N-Phenyltetraphenylporphyrin. (1987) (0)
- Design of CYP 2C18 and 2C19 substrates based on hydroxylation of 2-aroyl-thiophenes (1998) (0)
- Preparation and Properties of Iron(II), Cobalt(III), and Zinc(II) N-Alkylporphyrin Complexes Involving Five-Membered Cyclic Metal-O-C=C-N Metallacycles. (1987) (0)
- Oxidation of Arylamidoximes by Hydrogen Peroxide and Horseradish Peroxidase in Water: Easy Preparation and X-Ray Structure of 0-( Arylimidoyl)arylamidoximes. (1996) (0)
- CLEAVAGE OF SILICON-CARBON BONDS BY PLATINUM(II) COMPLEXES. II. REACTIONS OF VINYL-, ALLYL-, AND BUT-3-EN-1-YL-TRIMETHYLSILANES (1976) (0)
- HYDROXYLATION OF ELLIPTICINE IN THE RAT‐ STRUCTURE OF THE TWO PRINCIPAL METABOLITES. SYNTHESIS OF 7‐HYDROXYELLIPTICINE (1978) (0)
- Microsomal Cytochrome P450 2C5/3LVdH Complex with a dimethyl derivative of sulfaphenazole (2003) (0)
- Synthesis and spectroscopic characterizations of a binuclear [Mn(II)bipyridine-Fe(III)porphyrin] complex first evidence of catalytic production of Mn(III) as model of manganese peroxidase activity (1995) (0)
- Activation of Alkanes: The Biomimetic Approach (1993) (0)
- Allylic Amination of Alkenes by Tosyliminoiodobenzene: Manganese Porphyrins as Suitable Catalysts. (1988) (0)
- A New Easy Access to Quinones from Iron Porphyrin-Catalyzed Oxidation of Methoxyarenes by Magnesium Monoperoxyphthalate. (1991) (0)
- Unprecedented ipso Aromatic Nucleophilic Substitution upon Oxidative Decarboxylation of Tris(p‐carboxytetrathiaaryl)methyl (TAM) Radicals: A New Access to Diversely Substituted TAM Radicals. (2011) (0)
- Chapter 2. Catalytically Active Metalloporphyrin Models for Cytochrome P-450 (1989) (0)
- [P-450 cytochromes and mono-oxygenases. Mechanism of action. Consequences in pharmacology and toxicology (author's transl)]. (1980) (0)
- Preparation of Functionalized Polyhalogenated Tetraarylporphyrins by Selective Substitution of p‐Fluorines of meso‐Tetrakis( pentafluorophenyl)porphyrins. (1992) (0)
- O63. Inhibitory effects of a series of 7-substituted-indazoles towards nitric oxide synthases (2008) (0)
- Human Orphan Cytochrome P450 2U1 Catalyzes the ω-Hydroxylation of Leukotriene B4 (2022) (0)
- Cover Picture: Oxidative Metabolism of Ferrocene Analogues of Tamoxifen: Characterization and Antiproliferative Activities of the Metabolites (ChemMedChem 6/2015) (2015) (0)
- Arginase-F2-L-Arginine complex (2004) (0)
- Cytochromes P450 and drug toxicity. Immunological consequences. (1995) (0)
- REACTIONS OF TRICHLOROMETHYLTRIMETHYLSILANE WITH FERROTETRAARYL PORPHYRINS (1981) (0)
- METALLOPORPHYRIN-CATALYZED HYDROXYLATION OF CYCLOHEXANE BY ALKYL HYDROPEROXIDES: SPECIAL EFFICIENCY OF IRON PORPHYRINS (1981) (0)
- arginase-descarboxy-nor-NOHA complex (2005) (0)
- biological implications of the formation of these cytochrome P 450- iron-carbon bonds, (1980) (0)
- Manganese Porphyrins Adsorbed or Intercatalated in Different Mineral Matrices: Preparation and Compared Properties as Catalysts for Alkene and Alkane Oxidation. (1993) (0)
- Great adaptability of the heme-cysteinate monooxygenases family to very diverse substrates and sophisticated reactions (2007) (0)
- New drugs containing 1,2-dithiol compounds-3-thion-5-oxide. (1989) (0)
- Aziridination of Alkenes Catalyzed by Porphyrinirons: Selection of Catalysts for Optimal Efficiency and Stereospecificity. (1988) (0)
- Shape Selectivity for Alkane Hydroxylation with a New Class of Phosphonate‐Based Heterogenized Manganese Porphyrins. (1999) (0)
- Heme-Thiolate Proteins Differentfrom Cytochromes P450 Catalyzing (1995) (0)
- The Role of Drug Metabolism in Immune-Mediated Drug Toxicity : Molecular , Clinical and Mechanistic Aspects Poster (2013) (0)
- Arginase-dehydro-ABH complex (2005) (0)
- The dehydration of aldoximes to give nitriles: Chemical modelling of a recently discovered enzymatic activity cytochromes P450 (1995) (0)
- CCDC 736717: Experimental Crystal Structure Determination (2010) (0)
- Metalloporphyrino-silica: A new class of biomimetic oxidation catalysts (1995) (0)
- Structure-Activity Relationships of a New Family of Steroidal Aromatase Inhibitors. Part 1. Synthesis and Evaluation of a Series of Analogues Related to 19-((Methylthio)methyl)androstenedione (RU54115). (1996) (0)
- Spectroscopic characterization of a Fe(IV) intermediate with a non-porphyrin ligand. Hydroxylation and epoxidation activity (2003) (0)
- Diversity of catalytic functions of heme-thiolate proteins (1995) (0)
- ALKYLATION OF THE α AND Γ MESO POSITIONS OF TETRAPHENYLPORPHYRIN UPON REDUCTION OF ALLYL AND PROPARGYL BROMIDE BY IRON(II) TETRAPHENYLPORPHYRIN: A NEW ROUTE TO PORPHODIMETHENE COMPLEXES (1984) (0)
- STUDY OF HYDROXYLASE AND ITS COMPONENTS IN CANDIDA TROPICALIS GROWN ON ALKANE (1981) (0)
- REACTION OF IRON(II) TETRAPHENYLPORPHYRIN DICHLOROCARBENE COMPLEX WITH PRIMARY AMINES: FORMATION OF ISONITRILES (1978) (0)
- arginase-dinor-NOHA complex (2005) (0)
- EASY TRANSFORMATION OF BENZYLIC ALCOHOLS TO ARYLACETIC ALDEHYDES (1977) (0)
- THE TWO BINDING MODES OF N-HYDROXYGUANIDINES TO NO SYNTHASES : FIRST EVIDENCE FOR THE FORMATION OF IRON-N-HYDROXYGUANIDINE COMPLEXES AND KEY ROLE OF TETRAHYDROBIOPROTERIN DETERMINING THE BINDING MODE (2003) (0)
- Iron-Porphyrin-Nitrene Complexes: Preparation, Properties, and Crystal Structure of Porphyrin-Iron(III) Complexes with a Tosylnitrene Inserted into an Fe-N Bond. (1988) (0)
- 54 Ellipticines: antitumor properties and metabolism (1978) (0)
- New supported perhalogenated metalloporphyrin catalysts for biomimetic oxidations. (1993) (0)
- arginase-L-valine complex (2004) (0)
- Proceedings: P-450 carbene-complexes. (1975) (0)
- SELECTIVE ESTERIFICATIONS INDUCED BY PROXIMITY TO THE CENTER OF A PLATINUM COMPLEX (1976) (0)
- NEW IRON-PORPHYRIN COMPLEXES WITH METAL-CARBON BOND. BIOLOGICAL IMPLICATIONS (1980) (0)
- SUBSTITUTION REACTIONS OF 4-ALKOXYPYRIDINIUM SALTS (1976) (0)
- CCDC 1527404: Experimental Crystal Structure Determination (2017) (0)
- Synthesis and Effects on Arginase and Nitric Oxide Synthase of Two Novel Analogues of Nω-Hydroxyarginine, Nω- Hydroxyindospicine, and p-Hydroxyamidinophenylalanine. (1996) (0)
- Mössbauer study of (2-nitrisopropane)(n-methylimidazole) and (2-nitrosopropane)(isoropylamie) iron(II) tetraphenylporphyrins (1980) (0)
- RADICAL CYCLIZATIONS. XXIX. REDOX-CATALYZED CYCLIZATION OF Δ-ETHYLENIC BENZYL CHLORIDES (1976) (0)
- Kinetic nature of the inhibition of a mixed-function oxidase by hydroxylamines; effect of the pretreatment of rats by inducing agents. (1982) (0)
- Innenrücktitelbild: Ferrocenyl Quinone Methide-Thiol Adducts as New Antiproliferative Agents: Synthesis, Metabolic Formation from Ferrociphenols, and Oxidative Transformation (Angew. Chem. 35/2016) (2016) (0)
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