Daniel P. Kelly

Q: What Schools Are Affiliated With Daniel P. Kelly

Daniel P. Kelly is affiliated with the following schools: Washington University in St. Louis, University of Wisconsin–Madison, Sanford Burnham Prebys Medical Discovery Institute, Rush University, University of California, San Francisco, Massachusetts General Hospital, University of Utah, University of Pennsylvania, Harvard University

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Daniel P. Kelly

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#4213

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Philosophy

Why Is Daniel P. Kelly Influential?

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According to Wikipedia, Daniel P. Kelly is an American physician and Willard and Rhoda Ware Professor of Diabetes and Metabolic Diseases at the University of Pennsylvania. He is known for his contributions to biomedical research.

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Daniel P. Kelly's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. (2006) (1300)
Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. (2000) (1242)
The Coactivator PGC-1 Cooperates with Peroxisome Proliferator-Activated Receptor α in Transcriptional Control of Nuclear Genes Encoding Mitochondrial Fatty Acid Oxidation Enzymes (2000) (1191)
Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. (2004) (1189)
Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC‐1 (2002) (1039)
A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders. (1999) (969)
The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus. (2002) (935)
PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis (2005) (751)
Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1 (2001) (670)
Fatty acid oxidation enzyme gene expression is downregulated in the failing heart. (1996) (668)
Transcriptional integration of mitochondrial biogenesis (2012) (633)
The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression. (1994) (585)
A critical role for PPARα-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: Modulation by dietary fat content (2003) (513)
Mitochondrial energy metabolism in heart failure: a question of balance. (2005) (497)
Fatty Acids Activate Transcription of the Muscle Carnitine Palmitoyltransferase I Gene in Cardiac Myocytes via the Peroxisome Proliferator-activated Receptor α* (1998) (494)
Deactivation of peroxisome proliferator-activated receptor-alpha during cardiac hypertrophic growth. (2000) (486)
Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs (2012) (478)
PPAR signaling in the control of cardiac energy metabolism. (2000) (473)
Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy. (2002) (472)
Nuclear receptor signaling and cardiac energetics. (2004) (459)
Lipin 1 is an inducible amplifier of the hepatic PGC-1α/PPARα regulatory pathway (2006) (457)
The Failing Heart Relies on Ketone Bodies as a Fuel (2016) (456)
A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator- activated receptor alpha- deficient mice. (1998) (431)
Estrogen-Related Receptor α Directs Peroxisome Proliferator-Activated Receptor α Signaling in the Transcriptional Control of Energy Metabolism in Cardiac and Skeletal Muscle (2004) (414)
Peroxisome Proliferator-activated Receptor Coactivator-1α (PGC-1α) Coactivates the Cardiac-enriched Nuclear Receptors Estrogen-related Receptor-α and -γ (2002) (407)
Cardiac-Specific Induction of the Transcriptional Coactivator Peroxisome Proliferator-Activated Receptor &ggr; Coactivator-1&agr; Promotes Mitochondrial Biogenesis and Reversible Cardiomyopathy in a Developmental Stage-Dependent Manner (2004) (373)
Genome-wide Orchestration of Cardiac Functions by the Orphan Nuclear Receptors ERRα and γ (2007) (359)
PGC-1α Coactivates PDK4 Gene Expression via the Orphan Nuclear Receptor ERRα: a Mechanism for Transcriptional Control of Muscle Glucose Metabolism (2005) (320)
Mitochondrial biogenesis and dynamics in the developing and diseased heart (2015) (311)
Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice (2015) (308)
Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart. (2008) (305)
Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. (2006) (287)
A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes. (2005) (266)
The nuclear receptor ERRalpha is required for the bioenergetic and functional adaptation to cardiac pressure overload. (2007) (264)
Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice (2005) (260)
Transcriptional Activation Of Energy Metabolic Switches In The Developing And Hypertrophied Heart (2002) (254)
PPARalpha deficiency reduces insulin resistance and atherosclerosis in apoE-null mice. (2001) (246)
Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency. (2003) (244)
Nuclear receptors PPARβ/δ and PPARα direct distinct metabolic regulatory programs in the mouse heart (2007) (242)
A Role for the Transcriptional Coactivator PGC-1α in Muscle Refueling* (2007) (239)
Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity. (2010) (238)
p38 Mitogen-activated Protein Kinase Activates Peroxisome Proliferator-activated Receptor α (2001) (236)
Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma. (2007) (234)
CD36 Deficiency Rescues Lipotoxic Cardiomyopathy (2007) (229)
Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle. (2004) (229)
A Role for Peroxisome Proliferator-activated Receptor α (PPARα) in the Control of Cardiac Malonyl-CoA Levels (2002) (228)
Peroxisome Proliferator–Activated Receptor γ Coactivator-1 (PGC-1) Regulatory Cascade in Cardiac Physiology and Disease (2007) (226)
The PPAR trio: regulators of myocardial energy metabolism in health and disease. (2008) (223)
Dexamethasone induction of hypertension and diabetes is PPAR-α dependent in LDL receptor–null mice (2003) (222)
A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program. (1997) (221)
RGS4 causes increased mortality and reduced cardiac hypertrophy in response to pressure overload. (1999) (207)
Energy Metabolic Reprogramming in the Hypertrophied and Early Stage Failing Heart: A Multisystems Approach (2014) (204)
Fatty acid utilization in the hypertrophied and failing heart: molecular regulatory mechanisms. (1999) (199)
Insulin-Resistant Heart Exhibits a Mitochondrial Biogenic Response Driven by the Peroxisome Proliferator-Activated Receptor-&agr;/PGC-1&agr; Gene Regulatory Pathway (2007) (198)
Effect of endurance training on lipid metabolism in women: a potential role for PPARalpha in the metabolic response to training. (2000) (181)
PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism. (2005) (180)
Hypoxia inhibits the peroxisome proliferator-activated receptor alpha/retinoid X receptor gene regulatory pathway in cardiac myocytes: a mechanism for O2-dependent modulation of mitochondrial fatty acid oxidation. (2001) (180)
Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha. (2002) (176)
Gene Regulatory Mechanisms Governing Energy Metabolism during Cardiac Hypertrophic Growth (2002) (174)
Molecular Mechanisms Underlying Cardiac Adaptation to Exercise. (2017) (171)
Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism. (2013) (168)
Decreased Contractile and Metabolic Reserve in Peroxisome Proliferator–Activated Receptor-&agr;–Null Hearts Can Be Rescued by Increasing Glucose Transport and Utilization (2005) (168)
A Role for Peroxisome Proliferator-Activated Receptor &ggr; Coactivator-1 in the Control of Mitochondrial Dynamics During Postnatal Cardiac Growth (2014) (166)
Myocardial Fatty Acid Metabolism: Independent Predictor of Left Ventricular Mass in Hypertensive Heart Disease (2003) (162)
The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis. (2008) (162)
Nuclear receptors PPARbeta/delta and PPARalpha direct distinct metabolic regulatory programs in the mouse heart. (2007) (160)
The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense. (2019) (159)
A Role for Estrogen-related Receptor α in the Control of Mitochondrial Fatty Acid β-Oxidation during Brown Adipocyte Differentiation* (1997) (156)
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease. (2007) (156)
A role for the transcriptional coactivator PGC-1alpha in muscle refueling. (2007) (149)
Preferential Oxidation of Triacylglyceride-Derived Fatty Acids in Heart Is Augmented by the Nuclear Receptor PPAR&agr; (2010) (140)
Mitochondrial ultrastructural and molecular changes induced by zidovudine in rat hearts. (1991) (138)
Peroxisome Proliferator-activated Receptor α (PPARα) Signaling in the Gene Regulatory Control of Energy Metabolism in the Normal and Diseased Heart (2002) (136)
Mitochondrial protein hyperacetylation in the failing heart. (2016) (135)
The role of the peroxisome proliferator-activated receptor α (PPARα) in the control of cardiac lipid metabolism (1999) (124)
Rescue of Cardiomyopathy in Peroxisome Proliferator-Activated Receptor-α Transgenic Mice by Deletion of Lipoprotein Lipase Identifies Sources of Cardiac Lipids and Peroxisome Proliferator-Activated Receptor-α Activators (2010) (122)
Irisin, Light My Fire (2012) (118)
Cardiac-specific overexpression of peroxisome proliferator-activated receptor-alpha causes insulin resistance in heart and liver. (2005) (118)
The nuclear receptor PPARβ/δ programs muscle glucose metabolism in cooperation with AMPK and MEF2. (2011) (118)
Toll-Like Receptor-Mediated Inflammatory Signaling Reprograms Cardiac Energy Metabolism by Repressing Peroxisome Proliferator-Activated Receptor &ggr; Coactivator-1 Signaling (2011) (116)
The tissue-specific expression and developmental regulation of two nuclear genes encoding rat mitochondrial proteins. Medium chain acyl-CoA dehydrogenase and mitochondrial malate dehydrogenase. (1989) (115)
Skeletal muscle mitochondrial remodeling in exercise and diseases (2018) (114)
Sudden cardiac death in hypertrophic cardiomyopathy (1995) (107)
Liver fatty acid‐binding protein is required for high rates of hepatic fatty acid oxidation but not for the action of PPAR‐α in fasting mice (2004) (104)
Chronic Inhibition of Pyruvate Dehydrogenase in Heart Triggers an Adaptive Metabolic Response* (2011) (103)
Nucleotide sequence of medium-chain acyl-CoA dehydrogenase mRNA and its expression in enzyme-deficient human tissue. (1987) (103)
The energy substrate switch during development of heart failure: gene regulatory mechanisms (Review). (1998) (102)
Chronic activation of PPARα is detrimental to cardiac recovery after ischemia (2006) (101)
Mouse models of mitochondrial dysfunction and heart failure. (2005) (98)
Maintaining ancient organelles: mitochondrial biogenesis and maturation. (2015) (95)
Calcineurin and Calcium/Calmodulin-dependent Protein Kinase Activate Distinct Metabolic Gene Regulatory Programs in Cardiac Muscle* (2004) (94)
The PGC-1 cascade as a therapeutic target for heart failure. (2011) (92)
Mitochondrial Dysfunction in Heart Failure With Preserved Ejection Fraction (2019) (92)
Peroxisome proliferator-activated receptor alpha (PPARalpha) signaling in the gene regulatory control of energy metabolism in the normal and diseased heart. (2002) (89)
Molecular characterization of inherited medium-chain acyl-CoA dehydrogenase deficiency. (1990) (87)
Perturbations in the gene regulatory pathways controlling mitochondrial energy production in the failing heart. (2013) (87)
A Role for Peroxisome Proliferator-activated Receptor γ Coactivator 1 (PGC-1) in the Regulation of Cardiac Mitochondrial Phospholipid Biosynthesis*♦ (2013) (86)
A pleiotropic element in the medium-chain acyl coenzyme A dehydrogenase gene promoter mediates transcriptional regulation by multiple nuclear receptor transcription factors and defines novel receptor-DNA binding motifs (1994) (84)
PPARα suppresses insulin secretion and induces UCP2 in insulinoma cells (2002) (83)
Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency. (2019) (82)
Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis. (2015) (79)
Ubiquitin Proteasome-dependent Degradation of the Transcriptional Coactivator PGC-1α via the N-terminal Pathway* (2010) (76)
Implications of Altered Ketone Metabolism and Therapeutic Ketosis in Heart Failure (2020) (73)
Coupling of mitochondrial function and skeletal muscle fiber type by a miR‐499/Fnip1/AMPK circuit (2016) (73)
Mutations in the medium chain acyl‐CoA dehydrogenase (MCAD) gene (1992) (73)
Transcriptional control of a nuclear gene encoding a mitochondrial fatty acid oxidation enzyme in transgenic mice: role for nuclear receptors in cardiac and brown adipose expression (1996) (72)
The role of the peroxisome proliferator-activated receptor alpha (PPAR alpha) in the control of cardiac lipid metabolism. (1999) (71)
PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein (2015) (70)
Activation of a novel metabolic gene regulatory pathway by chronic stimulation of skeletal muscle. (1996) (68)
Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop (2019) (67)
Inherited cardiomyopathies. (1994) (67)
PPARs of the heart: three is a crowd. (2003) (67)
Sarcolipin Signaling Promotes Mitochondrial Biogenesis and Oxidative Metabolism in Skeletal Muscle (2018) (65)
Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation (2019) (65)
Transcriptional control of cardiac fuel metabolism and mitochondrial function. (2011) (64)
Sudden cardiac death in hypertrophic cardiomyopathy. Variability in phenotypic expression of beta-myosin heavy chain mutations. (1995) (62)
Hepatocyte nuclear factor-4 activates medium chain acyl-CoA dehydrogenase gene transcription by interacting with a complex regulatory element. (1993) (61)
Chronic activation of PPARalpha is detrimental to cardiac recovery after ischemia. (2006) (60)
Fatty Acid Synthase Modulates Homeostatic Responses to Myocardial Stress* (2011) (59)
Cell biology: Ageing theories unified (2011) (58)
Characterization of wild-type and an active site mutant of human medium chain acyl-CoA dehydrogenase after expression in Escherichia coli. (1990) (57)
Ketone Ester Treatment Improves Cardiac Function and Reduces Pathologic Remodeling in Preclinical Models of Heart Failure (2020) (55)
Identification of a novel retinoid-responsive element in the promoter region of the medium chain acyl-coenzyme A dehydrogenase gene. (1992) (54)
The Human Medium Chain Acyl-CoA Dehydrogenase Gene Promoter Consists of a Complex Arrangement of Nuclear Receptor Response Elements and Sp1 Binding Sites (*) (1995) (52)
Therapeutic Potential of Ketone Bodies for Patients With Cardiovascular Disease: JACC Focus Seminar. (2021) (52)
Cardiac nuclear receptors: architects of mitochondrial structure and function (2017) (50)
Metabolic Dysfunction Consistent With Premature Aging Results From Deletion of Pim Kinases (2014) (49)
Exercise Inducible Lactate Dehydrogenase B Regulates Mitochondrial Function in Skeletal Muscle* (2016) (48)
A Critical Role for Estrogen-Related Receptor Signaling in Cardiac Maturation (2020) (46)
Retinoid X Receptor α Represses GATA-4-mediated Transcription via a Retinoid-dependent Interaction with the Cardiac-enriched Repressor FOG-2* (2003) (45)
The transcriptional coactivators, PGC-1α and β, cooperate to maintain cardiac mitochondrial function during the early stages of insulin resistance. (2012) (45)
MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling. (2016) (44)
Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice. (2009) (44)
PPARalpha suppresses insulin secretion and induces UCP2 in insulinoma cells. (2002) (44)
Structural organization and regulatory regions of the human medium-chain acyl-CoA dehydrogenase gene. (1992) (44)
Bcl3 Interacts Cooperatively with Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Coactivator 1α To Coactivate Nuclear Receptors Estrogen-Related Receptor α and PPARα (2009) (41)
PPARalpha-mediated remodeling of repolarizing voltage-gated K+ (Kv) channels in a mouse model of metabolic cardiomyopathy. (2008) (41)
G-protein signaling participates in the development of diabetic cardiomyopathy. (2004) (39)
Novel mouse model of left ventricular pressure overload and infarction causing predictable ventricular remodelling and progression to heart failure (2015) (38)
Signalling in cardiac metabolism. (2008) (36)
KDM5B Promotes Drug Resistance by Regulating Melanoma-Propagating Cell Subpopulations (2018) (32)
Extreme Acetylation of the Cardiac Mitochondrial Proteome Does Not Promote Heart Failure (2020) (32)
Mitochondrial function in melanoma. (2014) (32)
The complete nucleotide sequence of canine brain B creatine kinase mRNA: homology in the coding and 3' noncoding regions among species. (1986) (32)
Molecular basis of inherited medium-chain acyl-CoA dehydrogenase deficiency causing sudden child death (1992) (31)
Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics (2019) (31)
Skeletal Muscle Energetics and Mitochondrial Function Are Impaired Following 10 Days of Bed Rest in Older Adults (2020) (31)
Fetal PGC-1α Overexpression Programs Adult Pancreatic β-Cell Dysfunction (2013) (30)
Liver-Specific PGC-1beta Deficiency Leads to Impaired Mitochondrial Function and Lipogenic Response to Fasting-Refeeding (2012) (30)
PGC1α Plays a Critical Role in TWEAK–Induced Cardiac Dysfunction (2013) (30)
Detection and assessment by positron emission tomography of a genetically determined defect in myocardial fatty acid utilization (long-chain acyl-CoA dehydrogenase deficiency). (1993) (29)
Regulation of ATP synthase subunit e gene expression by hypoxia: cell differentiation stage-specific control. (1997) (29)
Impaired Mitochondrial Energetics Characterize Poor Early Recovery of Muscle Mass Following Hind Limb Unloading in Old Mice (2018) (29)
Characterization of altered myocardial fatty acid metabolism in patients with inherited cardiomyopathy (2001) (28)
Molecular characterization of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency: identification of a lys329 to glu mutation in the MCAD gene, and expression of inactive mutant enzyme protein in E. coli (1991) (28)
Transcriptional regulation by glucocorticoids of mitochondrial oxidative enzyme genes in the developing rat kidney. (1996) (28)
Regulatory networks controlling mitochondrial energy production in the developing, hypertrophied, and diabetic heart. (2002) (25)
Loss of mitochondrial energetics is associated with poor recovery of muscle function but not mass following disuse atrophy (2019) (25)
Identification of a Retinoid/Chicken Ovalbumin Upstream Promoter Transcription Factor Response Element in the Human Retinoid X Receptor γ2 Gene Promoter* (1997) (24)
Interaction between PPARA genotype and beta-blocker treatment influences clinical outcomes following acute coronary syndromes. (2008) (22)
Peripheral Determinants of Oxygen Utilization in Heart Failure With Preserved Ejection Fraction (2020) (21)
The PPAR-RXR Transcriptional Complex in the Vasculature Energy in the Balance (2011) (21)
Cost of transport is increased after cold exposure in Monodelphis domestica: training for inefficiency (2005) (21)
Angiotensin-converting enzyme inhibitors in adults with cyanotic congenital heart disease. (1996) (20)
A PPARα Promoter Variant Impairs ERR-Dependent Transactivation and Decreases Mortality after Acute Coronary Ischemia in Patients with Diabetes (2010) (20)
The pleiotropic nature of the vascular PPAR gene regulatory pathway. (2001) (20)
Mitochondrial transcription factor A is increased but expression of ATP synthase beta subunit and medium-chain acyl-CoA dehydrogenase genes are decreased in hearts of copper-deficient rats. (2000) (19)
MondoA drives muscle lipid accumulation and insulin resistance. (2019) (19)
Novel Göttingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities (2021) (19)
Interaction between the UCP2 -866 G>A polymorphism, diabetes, and β-blocker use among patients with acute coronary syndromes (2010) (18)
Hypoxic reprogramming (2008) (18)
Three RFLPs defining a haplotype associated with the common mutation in human medium-chain acyl-CoA dehydrogenase (MCAD) deficiency occur in Alu repeats. (1993) (17)
Structure and chromosomal location of the mouse medium-chain acyl-CoA dehydrogenase-encoding gene and its promoter. (1996) (16)
Fetal PGC-1 alpha Overexpression Programs Adult Pancreatic beta-Cell Dysfunction (2013) (15)
Differential effects of luminal arginine and glutamine on metalloproteinase production in the postischemic gut. (2008) (15)
Introducing JACC: Basic to Translational Science (2016) (14)
A missense mutation in the β myosin heavy chain gene is a predictor of premature sudden death in patients with hypertrophic cardiomyopathy (1994) (14)
The role of PPAR alpha as a "lipostat" transcription factor. (1999) (13)
Hypoxia Inhibits the Peroxisome Proliferator-activated Receptor α/ Retinoid X Receptor Gene Regulatory Pathway in Cardiac Myocytes (2001) (13)
Peroxisome Proliferator-Activated Receptor α as a Genetic Determinant of Cardiac Hypertrophic Growth (2002) (12)
Harnessing the Power of Integrated Mitochondrial Biology and Physiology: A Special Report on the NHLBI Mitochondria in Heart Diseases Initiative. (2015) (12)
Circadian REV-ERBs repress E4bp4 to activate NAMPT-dependent NAD+ biosynthesis and sustain cardiac function (2021) (11)
Acute Echocardiographic Effects of Exogenous Ketone Administration in Healthy Participants. (2021) (11)
Skeletal muscle PGC-1β signaling is sufficient to drive an endurance exercise phenotype and to counteract components of detraining in mice. (2017) (11)
Multimodality assessment of heart failure with preserved ejection fraction skeletal muscle reveals differences in the machinery of energy fuel metabolism (2021) (10)
Mitochondrial Biogenesis and Maturation (2015) (10)
A silent A to G mutation in exon 11 of the medium-chain acyl-CoA dehydrogenase (MCAD) gene. (1993) (10)
The Role of PPARα as a“lipostat” Transcription Factor (2002) (10)
Single-Nucleotide Polymorphism of the MLX Gene Is Associated With Takayasu Arteritis (2018) (9)
Molecular analysis of medium chain acyl-CoA dehydrogenase deficiency. (1990) (8)
Evidence for a Novel Cardiac-enriched Retinoid X Receptor Partner* (1999) (8)
Fueling Cardiac Hypertrophy. (2020) (7)
Expression and Characterization of Human Mutant (Glutamic Acid304) Medium-Chain Acyl-Coenzyme A Dehydrogenase in Mammalian Cells (1993) (7)
The nuclear receptor ERR cooperates with the cardiogenic factor GATA4 to orchestrate cardiomyocyte maturation (2022) (6)
Response to Letter Regarding Article, “Toll-like Receptor-Mediated Inflammatory Signaling Reprograms Cardiac Energy Metabolism by Repressing Peroxisome Proliferator-Activated Receptor γ Coactivator-I Signaling” (2011) (6)
Characterization of the human very-long-chain acyl-CoA dehydrogenase gene promoter region: a role for activator protein 2. (1999) (6)
Characterization of a disease-causing Lys329 to Glu mutation in 16 patients with medium-chain Acyl-CoA dehydrogenase deficiency (1991) (5)
Identification of Inhibitors of Triacylglyceride Accumulation in Muscle Cells (2014) (5)
Peroxisome proliferator-activated receptor alpha as a genetic determinant of cardiac hypertrophic growth: culprit or innocent bystander? (2002) (5)
A missense mutation in the beta myosin heavy chain gene is a predictor of premature sudden death in patients with hypertrophic cardiomyopathy. (1994) (4)
Erratum: Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity (Cell Metabolism) (2011) (4)
Glutaminolysis is Essential for Myofibroblast Persistence and In Vivo Targeting Reverses Fibrosis and Cardiac Dysfunction in Heart Failure. (2022) (4)
Nuclear Receptor Signaling and Cardiac Energetics PPARs and Atherogenesis: Regulators of Gene Expression in Vascular Cells Nuclear Receptor Signaling in the Control of Cholesterol Homeostasis (2004) (4)
Defects in the Proteome and Metabolome in Human Hypertrophic Cardiomyopathy (2022) (3)
Response to Handschin and Spiegelman (2011) (3)
In Vivo Dissection of Chamber-Selective Enhancers Reveals Estrogen-Related Receptor as a Regulator of Ventricular Cardiomyocyte Identity (2023) (3)
A Case for Adaptive Cardiac Hypertrophic Remodeling Is CITED. (2020) (3)
Ketolysis is a metabolic driver of CD8+ T cell effector function through histone acetylation (2022) (2)
Novel communication between myocyte lipid storage and fat burning unveiled. (2012) (2)
Some Properties of Glu-376-Gln Active Site Mutant of Human Medium-Chain Acyl-CoA Dehydrogenase (1991) (2)
Transcriptional Control of Mitochondrial Biogenesis and Maturation (2014) (2)
Molecular studies of mouse medium and long-chain acyl-CoA dehydrogenase genes for site-directed mutagenesis of embryonic stem cells. (1992) (2)
HPV E6 regulates therapy responses in oropharyngeal cancer by repressing the PGC-1α/ERRα axis (2022) (2)
Myocardial Metabolomics of Human Heart Failure With Preserved Ejection Fraction (2023) (2)
Cardiovascular Drug Discovery in the Academic Setting: Building Infrastructure, Harnessing Strengths, and Seeking Synergies (2010) (2)
Mitochondrial Dynamics During Postnatal Cardiac Growth Coactivator-1 in the Control of γ A Role for Peroxisome Proliferator-Activated Receptor (2014) (1)
THE ROLE OF AS A "LIPOSTAT" TRANSCRIPTION FACTOR (1999) (1)
Introduction to the nuclear receptor review series. (2010) (1)
Energy Metabolic Re-Programming in the Hypertrophied and Early Stage Failing Heart: A Multi-systems Approach Lai et al: Metabolic Remodeling in Heart Failure (2014) (1)
Ketones and the Heart: Metabolic Principles and Therapeutic Implications (2023) (1)
Empagliflozin and the Prevention of Heart Failure (2017) (1)
Genetic Modification of the Heart Mouse models of mitochondrial dysfunction and heart failure (2005) (1)
Estrogen Signaling and Cardiovascular Disease (2011) (1)
The Molecular Basis of Cardiomyopathies Due to Genetic Deficiencies of Mitochondrial Proteins (1998) (1)
Transcriptional Control of Striated Muscle Mitochondrial Biogenesis and Function (2012) (1)
Current concepts of the molecular basis of heart failure. (1994) (1)
Molecular characterization of medium-chain acyl-CoA dehydrogenase deficiency causing sudden death. (1992) (1)
Nicotinamide Riboside Improves Cardiac Function and Prolongs Survival After Disruption of the Cardiomyocyte Clock (2022) (1)
The human medium chain acyl-CoA dehydrogenase gene promoter consists of a complex arrangement of nuclear receptor response elements and Sp1 binding sites. (1995) (1)
Abstract 3065: Acute Deactivation of Cardiac PGC-1 Signaling in Adult Mice Causes Cardiomyopathy Associated With Derangements in Mitochondrial Structure (2009) (0)
Scheme 1, Synthesis of ML377 (2015) (0)
Liver fatty acidâ•’binding protein is required for high rates of hepatic fatty acid oxidation but not for the action of PPARâ•’Î± in fasting mice (2003) (0)
Human papilloma virus E6 regulates therapy responses in oropharyngeal cancer by repressing the PGC-1α/ERRα axis (2022) (0)
Abstract P386: Supplementation Of Tyrode With Fatty Acids And 3-hydroxybutyrate Improves Adult Cardiomyocytes Contractility Of Failing Human Hearts. (2021) (0)
PPARα regulates cardiac energy metabolism by controlling malonyl COA concentrations in the heart (2001) (0)
Abstract 110: The Estrogen-related Receptor Gamma Promotes Maturation of iPSC-derived Cardiac Myocytes (2016) (0)
1142-180 Peroxisome proliferator-activated receptor-alpha intron 7 polymorphism exhibits racial dimorphism and is associated with increased left ventricular mass (2004) (0)
Figure 3, Potency of ML377 inhibition for triacylglycerol accumulation in both H9c2 cells and differentiated human skeletal myotubes (2015) (0)
Low fatty acid oxidation rates in isolated working hearts from PPAR alpha null mice does not impair functional recovery following ischemia (2001) (0)
COMPREHENSIVE NUTRIENT CONSUMPTION AND METABOLIC PROFILING DURING KETOGENIC DIET AND RELATIONSHIP WITH MYOCARDIAL GLUCOSE UPTAKE ON FDG-PET (2022) (0)
What's Your Availability? Novel Substrate Design for DNA Catalytic Reaction Networks Based on Thermodynamic Analysis of Target Molecules (2016) (0)
The tissue-specific and developmental regulation of expression of rat medium-chain acyl-CoA dehydrogenase mRNA. (1990) (0)
Abstract 2384: Calcineurin-mediated Activation of the Human PPAR{gamma} Coactivator-1{alpha} (PGC-1{alpha}) Gene promoter is Influenced by Haplotype (2006) (0)
Figure 2, Stability of ML377 in 1× PBS at RT (2015) (0)
Metabolic and Proteomic Defects in Human Hypertrophic Cardiomyopathy (2021) (0)
Myocardial Disease Altered Myocardial Fatty Acid and Glucose Metabolism in Idiopathic Dilated Cardiomyopathy (2016) (0)
Identification and characterization of the 5' regulatory region of the human medium-chain acyl-CoA dehydrogenase (MCAD) gene. (1992) (0)
4582 NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD) DEPLETION MUST BE SEVERE TO INDUCE CARDIAC DYSFUNCTION AND EVENTUAL FAILURE (2020) (0)
Abstract 517: Glutaminolysis is Required to Initiate Myofibroblast Differentiation and Persistence During Stress (2019) (0)
JACC: Basic to Translational Science Top Reviewers 2022: With Appreciation and Gratitude (2023) (0)
Empagli fl ozin and the Prevention of Heart Failure Will Reverse Translation Lead to New Paradigms for the Treatment of Heart Failure ? * (2017) (0)
Ketone Bodies as a Therapeutic Strategy for Heart Failure (2019) (0)
MBNL1 regulates programmed postnatal switching between regenerative and differentiated cardiac states (2023) (0)
JACC: Basic to Translational Science Top Reviewers 2021: With Appreciation (2022) (0)
PPARs of the Heart Three Is a (2003) (0)
Bcl3 Interacts Cooperatively with Peroxisome Proliferator-Activated Receptor Gamma (PPAR (cid:2) ) Coactivator 1 (cid:3) To Coactivate Nuclear Receptors Estrogen-Related Receptor (cid:3) and PPAR (cid:3) (cid:1) † (2009) (0)
A human mitofusin 2 mutation causes mitophagic cardiomyopathy (2022) (0)
Abstract 13487: A Key Role for the PGC-1 Transcriptional Coactivators in Cardiac Postnatal Mitochondrial Maturation and Dynamics (2011) (0)
Abstract 19005: PGC1α Play a Critical Role in TWEAK Mediating Cardiac Dysfunction (2012) (0)
wheel running in the mouse Cardiac and skeletal muscle adaptations to voluntary (2015) (0)
Figure 1, Structure of ML377 (2015) (0)
Abstract 562: Comprehensive Arteriovenous Metabolomics in the Human Heart (2019) (0)
Tissue-specific expression and developmental regulation of rat medium-chain acyl-CoA dehydrogenase (1987) (0)
EFFECT OF IMMUNE ENHANCING AGENTS ON MMP PRODUCTION IN THE JEJUNUM FOLLOWING INTESTINAL ISCHEMIA/REPERFUSION INJURY (2006) (0)
TLR4-Mediated Signals Converge on the PGC-1 Family of Nuclear Receptor Coactivators to Control Myocardial Metabolism and Function (2009) (0)
PGC-1: A Physiologic Transducer Linked to Gene Regulatory Networks Controlling Cardiac Metabolism and Function (2006) (0)
Metabolite profile and mitochondrial energetics characterize poor early recovery of muscle mass following hind limb unloading in old mice (2017) (0)
Abstract 13921: Targeting Receptor-Interacting Protein 140 to Modulate Energy Metabolism in the Failing Heart (2020) (0)
Table 4, Summary of in vitro ADME Properties of TAG inhibitor probe ML377 (2015) (0)
Abstract 3692: PPARA Genotype is Associated with Differential Response to Beta-Blocker Therapy in Patients Following Acute Coronary Syndromes (2006) (0)
Abstract 1819: Co-Upregulation of Peroxisome Proliferator-Activated Receptor-Alpha (PPARalpha) and Silent Information Regulator 1 (Sirt1) Negatively Regulates Cardiac Function Under Pressure Overload Induced Heart Failure (2008) (0)
RIP140 deficiency enhances cardiac fuel metabolism and protects mice from heart failure (2023) (0)
Table 3, Probe and Analog Submissions to MLSMR (Evotec) for TAG inhibitors (2015) (0)
Abstract 20546: PPARalpha-Sirt1 Complex Downregulates Mitochondrial Gene Expression Through Suppression of the ERR Response Element in the Heart Under Pressure Overload (2010) (0)
Abstract 16406: Epigenetic Regulation of Myofibroblast Differentiation and Persistence is Mediated by Enhanced Glutaminolysis (2020) (0)
Special Issue: The evolving role of mitochondria in metabolism (2012) (0)
Ketone body metabolism declines with age in mice in a sex-dependent manner (2022) (0)
PGC-1 (cid:2) Coactivates PDK4 Gene Expression via the Orphan Nuclear Receptor ERR (cid:2) : a Mechanism for Transcriptional Control of Muscle Glucose Metabolism (2005) (0)
Abstract 222: The Estrogen-related Receptor (ERR) Drives Cardiac Myocyte Maturation in Cooperation With GATA4 (2020) (0)
03 Alterations in fatty acid utilization modulate voltage-dependent K+ currents in mouse ventricular myocytes (2002) (0)
Abstract 14182: Identification of a Candidate Alternative Fuel Source in the Failing Heart Using Quantitative Mitochondrial Proteomics and Metabolomics (2011) (0)
Abstract 14219: Enhancing Cardiac Beta-Hydroxybutyrate Consumption Halts the Progression From Compensated to Decompensated Heart Failure in Dogs With Tachypacing-Induced Dilated Cardiomyopathy (2018) (0)
Abstract 9576: A Nuclear Receptor-microRNA Circuit Links Control of Muscle Fiber Type to Energy Metabolism (2012) (0)
Abstract 648: Cardiac Lipoprotein Lipase Deficiency Rescues Lipotoxic Cardiomyopathy and Identifies a Distinct Cellular PPAR{alpha} Signaling Pathway (2007) (0)
Abstract 5382: Accelerated Triacylglyceride Dynamics Induced by Cardiac PPAR{alpha} Overexpression are Potentiated by Adrenergic Stress to Reveal Increased Reliance on Endogenous Lipid Stores (2008) (0)
Control of Macrophage Activation and Function by PPARs (2010) (0)
Abstract 113: Targeting Receptor-interacting Protein 140 (RIP140) To Modulate Energy Metabolism In The Failing Heart (2021) (0)
Inhibitors of Myocyte Triacylglyceride Accumulation (2015) (0)
PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein (2015) (0)
Peroxisome Proliferator–Activated Receptor (cid:1) Coactivator-1 (PGC-1) Regulatory Cascade in Cardiac Physiology and Disease Basic Science for Clinicians (2007) (0)
Decreased triglyceride turnover in PGC1αKO mice during adrenergic stress (2007) (0)
Increasing fatty acid oxidation in the failing heart does not improve cardiac function (2018) (0)
Hypertrophic Growth : Culprit or Innocent Bystander ? as a Genetic Determinant of Cardiac α Peroxisome Proliferator-Activated Receptor (2002) (0)
Abstract 13898: Estrogen-Related Receptor Signaling is Critical for Postnatal Cardiac Maturation (2019) (0)
Abstract 12289: The Nuclear Receptor NR4A1 Regulates Transcriptional Programs Involved in Cardiac Fuel Metabolism and Hypertrophic Growth (2015) (0)
Skeletal muscle mitochondrial remodeling in exercise and diseases (2018) (0)

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