Daniel W. Nebert
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American physician-scientist
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Daniel W. Nebert's Degrees
- Doctorate Medicine University of Cincinnati
- PhD Pharmacology University of Cincinnati
Why Is Daniel W. Nebert Influential?
(Suggest an Edit or Addition)According to Wikipedia, Daniel Walter Nebert is an American physician-scientist. He is a professor emeritus at the University of Cincinnati College of Medicine. His research has revolved around the central theme of gene–environment interaction.
Daniel W. Nebert's Published Works
Published Works
- P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. (1996) (2884)
- P450 genes: structure, evolution, and regulation. (1987) (1576)
- Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. I. Assay and properties of induced enzyme. (1968) (1534)
- Clinical importance of the cytochromes P450 (2002) (1344)
- Role of Aryl Hydrocarbon Receptor-mediated Induction of the CYP1 Enzymes in Environmental Toxicity and Cancer* (2004) (1114)
- The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. (1997) (1089)
- The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature. (1991) (1056)
- Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (2004) (999)
- Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis. (2000) (973)
- The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis (2006) (834)
- Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. (2005) (827)
- The P450 gene superfamily: recommended nomenclature. (1987) (774)
- Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents (1989) (721)
- Characterization of the common genetic defect in humans deficient in debrisoquine metabolism (1988) (714)
- Human ATP-binding cassette (ABC) transporter family (2009) (619)
- Metabolism of polycyclic aromatic hydrocarbons: etiologic role in carcinogenesis. (1982) (565)
- The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromosomal loci. (1989) (552)
- Evolution of the P450 gene superfamily: animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation. (1990) (505)
- The Ah locus: genetic differences in toxicity, cancer, mutation, and birth defects. (1989) (462)
- Role of the Ah Receptor and the Dioxin‐Inducible [Ah] Gene Battery in Toxicity, Cancer, and Signal Transduction a (1993) (454)
- The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal states. (1969) (412)
- Nomenclature for human CYP2D6 alleles. (1996) (409)
- Human cytochromes P450 in health and disease (2013) (392)
- Regulatory gene product of the Ah locus. Characterization of the cytosolic inducer-receptor complex and evidence for its nuclear translocation. (1979) (352)
- Human drug-metabolizing enzyme polymorphisms: effects on risk of toxicity and cancer. (1996) (335)
- Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family (2005) (334)
- Analysis and update of the human solute carrier (SLC) gene superfamily (2009) (326)
- Feedback Control of AHR Signaling Regulates Intestinal Immunity (2017) (319)
- Oral exposure to benzo[a]pyrene in the mouse: detoxication by inducible cytochrome P450 is more important than metabolic activation. (2004) (316)
- ZIP8, Member of the Solute-Carrier-39 (SLC39) Metal-Transporter Family: Characterization of Transporter Properties (2006) (309)
- Analysis of the glutathione S-transferase (GST) gene family (2004) (301)
- Slc39a14 Gene Encodes ZIP14, A Metal/Bicarbonate Symporter: Similarities to the ZIP8 Transporter (2008) (296)
- Evolutionary divergence and functions of the human interleukin (IL) gene family (2010) (290)
- Genetic expression of aryl hydrocarbon hydroxylase activity. Induction of monooxygenase activities and cytochrome P1-450 formation by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice genetically "nonresponsive" to other aromatic hydrocarbons. (1974) (281)
- The vascular system as a target of metal toxicity. (2008) (275)
- Proposed role of drug-metabolizing enzymes: regulation of steady state levels of the ligands that effect growth, homeostasis, differentiation, and neuroendocrine functions. (1991) (274)
- Update on the aldehyde dehydrogenase gene (ALDH) superfamily (2011) (272)
- Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis. (2005) (265)
- Genetic mechanisms controlling the induction of polysubstrate monooxygenase (P-450) activities. (1981) (262)
- The UDP glucuronosyltransferase gene superfamily: suggested nomenclature based on evolutionary divergence. (1991) (257)
- Genetically altered mice to evaluate glutathione homeostasis in health and disease. (2004) (256)
- Role of genetics and drug metabolism in human cancer risk. (1991) (252)
- Initial Characterization of the Glutamate-Cysteine Ligase Modifier Subunit Gclm(−/−) Knockout Mouse (2002) (247)
- ZIP8 regulates host defense through zinc-mediated inhibition of NF-κB. (2013) (245)
- Pharmacogenetics and pharmacogenomics: why is this relevant to the clinical geneticist? (1999) (242)
- The chemical defensome: environmental sensing and response genes in the Strongylocentrotus purpuratus genome. (2006) (235)
- Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse (1975) (232)
- Oral Benzo[a]pyrene in Cyp1 Knockout Mouse Lines: CYP1A1 Important in Detoxication, CYP1B1 Metabolism Required for Immune Damage Independent of Total-Body Burden and Clearance Rate (2006) (225)
- Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous. (2000) (221)
- Genetic regulation of aryl hydrocarbon hydroxylase induction. II. Simple Mendelian expression in mouse tissues in vivo. (1972) (218)
- Eukaryotic aldehyde dehydrogenase (ALDH) genes: human polymorphisms, and recommended nomenclature based on divergent evolution and chromosomal mapping. (1999) (216)
- Human dioxin-inducible cytochrome P1-450: complementary DNA and amino acid sequence. (1985) (215)
- SLC39A8 Deficiency: A Disorder of Manganese Transport and Glycosylation. (2015) (214)
- Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. II. Cellular responses during enzyme induction. (1968) (210)
- Aryl hydrocarbon hydroxylase induction by polycyclic hydrocarbons: simple autosomal dominant trait in the mouse. (1972) (206)
- Drug-metabolizing enzymes in ligand-modulated transcription. (1994) (206)
- Temperature-dependent cytosol-to-nucleus translocation of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in continuous cell culture lines. (1980) (205)
- Cellular responses to oxidative stress: the [Ah] gene battery as a paradigm. (1990) (204)
- Update of human and mouse forkhead box (FOX) gene families (2010) (202)
- The Ah locus and the metabolism of chemical carcinogens and other foreign compounds. (1977) (200)
- Trout P450IA1: cDNA and deduced protein sequence, expression in liver, and evolutionary significance. (1988) (200)
- NAD(P)H:quinone oxidoreductase (NQO1) polymorphism, exposure to benzene, and predisposition to disease: A HuGE review (2002) (198)
- Human CYP1A1 gene: cosegregation of the enzyme inducibility phenotype and an RFLP. (1991) (197)
- Dioxin induces expression of c-fos and c-jun proto-oncogenes and a large increase in transcription factor AP-1. (1992) (193)
- Aryl hydrocarbon hydroxylase activity in human placenta from cigarette smoking and nonsmoking women. (1969) (180)
- Evolution of the cytochrome P450 genes. (1989) (178)
- Update of the human and mouse SERPIN gene superfamily (2013) (177)
- Tissue-specific expression of the mouse dioxin-inducible P(1)450 and P(3)450 genes: differential transcriptional activation and mRNA stability in liver and extrahepatic tissues (1986) (176)
- Glutathione defense mechanism in liver injury: insights from animal models. (2013) (175)
- Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16. (1988) (175)
- Genetic expression of aryl hydrocarbon hydroxylase induction. IV. Interaction of various compounds with different forms of cytochrome P-450 and the effect on benzo(a)pyrene metabolism in vitro. (1972) (168)
- Dioxin causes a sustained oxidative stress response in the mouse. (1998) (166)
- Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin. (2006) (165)
- Update of the NAD(P)H:quinone oxidoreductase (NQO) gene family (2006) (165)
- The murine Ah locus: in utero toxicity and teratogenesis associated with genetic differences in benzo[a]pyrene metabolism. (1979) (164)
- Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22. (1988) (160)
- The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis. (2010) (159)
- Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism. (1996) (156)
- The murine Ah locus. Comparison of the complete cytochrome P1-450 and P3-450 cDNA nucleotide and amino acid sequences. (1984) (156)
- Dioxin-dependent activation of murine Cyp1a-1 gene transcription requires protein kinase C-dependent phosphorylation (1992) (155)
- Mitochondrial reactive oxygen production is dependent on the aromatic hydrocarbon receptor. (2002) (154)
- Ontogenetic expression of polycyclic aromatic compound-inducible monooxygenase activities and forms of cytochrome P-450 in rabbit. Evidence for temporal control and organ specificity of two genetic regulatory systems. (1977) (153)
- Endogenous Functions of the Aryl Hydrocarbon Receptor (AHR): Intersection of Cytochrome P450 1 (CYP1)-metabolized Eicosanoids and AHR Biology* (2008) (153)
- Complete cDNA and protein sequence of a pregnenolone 16 alpha-carbonitrile-induced cytochrome P-450. A representative of a new gene family. (1985) (153)
- Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family Published, JLR Papers in Press, August 1, 2004. DOI 10.1194/jlr.E400002-JLR200 (2004) (152)
- The Ah locus: Correlation of intranuclear appearance of inducer-receptor complex with induction of cytochrome P1-450 mRNA (1982) (149)
- Update on the olfactory receptor (OR) gene superfamily (2008) (148)
- Regulatory gene product of the Ah locus. Characterization of receptor mutants among mouse hepatoma clones. (1982) (148)
- Aryl hydrocarbon receptor (AHR): "pioneer member" of the basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family of "sensors" of foreign and endogenous signals. (2017) (147)
- Regulation of the mammalian cytochrome P1-450 (CYP1A1) gene. (1989) (146)
- Autosomal-Recessive Intellectual Disability with Cerebellar Atrophy Syndrome Caused by Mutation of the Manganese and Zinc Transporter Gene SLC39A8. (2015) (146)
- Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression. (1989) (145)
- Structural gene products of the Ah locus. Transcriptional regulation of cytochrome P1-450 and P3-450 mRNA levels by 3-methylcholanthrene. (1984) (142)
- Debrisoquine 4-hydroxylase: characterization of a new P450 gene subfamily, regulation, chromosomal mapping, and molecular analysis of the DA rat polymorphism. (1987) (140)
- Cd2+ versus Zn2+ uptake by the ZIP8 HCO3--dependent symporter: kinetics, electrogenicity and trafficking. (2008) (139)
- Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism. (1985) (139)
- Genetic control of interindividual variations in the inducibility of aryl hydrocarbon hydroxylase in cultured human lymphocytes. (1976) (138)
- Glutathione Redox State Regulates Mitochondrial Reactive Oxygen Production* (2005) (137)
- Autoregulation plus upstream positive and negative control regions associated with transcriptional activation of the mouse P1(450) gene. (1985) (137)
- The Evolution of Drug Metabolism (2000) (137)
- Polymorphisms in drug-metabolizing enzymes: what is their clinical relevance and why do they exist? (1997) (134)
- Update of the human and mouse Fanconi anemia genes (2015) (132)
- Isolation and sequence of cDNA encoding a cytochrome P-450 from an insecticide-resistant strain of the house fly, Musca domestica. (1989) (130)
- Structural gene products of the Ah locus. Genetic and immunochemical evidence for two forms of mouse liver cytochrome P-450 induced by 3-methylcholanthrene. (1979) (130)
- Sulfobetaine derivatives of bile acids: nondenaturing surfactants for membrane biochemistry. (1983) (126)
- Aldehyde dehydrogenase (ALDH) superfamily in plants: gene nomenclature and comparative genomics (2012) (126)
- Glutamate Cysteine Ligase Catalysis (2005) (123)
- Multiple forms of cytochrome P-450 and the importance of molecular biology and evolution. (1982) (122)
- Genetic epidemiology of environmental toxicity and cancer susceptibility: human allelic polymorphisms in drug-metabolizing enzyme genes, their functional importance, and nomenclature issues. (1999) (119)
- Targeted knockout of Cyp1a1 gene does not alter hepatic constitutive expression of other genes in the mouse [Ah] battery. (2000) (118)
- Dioxin exposure is an environmental risk factor for ischemic heart disease (2007) (118)
- Cyp1a1(-/-) male mice: protection against high-dose TCDD-induced lethality and wasting syndrome, and resistance to intrahepatocyte lipid accumulation and uroporphyria. (2004) (117)
- Dioxin increases reactive oxygen production in mouse liver mitochondria. (2002) (117)
- Oral Benzo[a]pyrene: Understanding Pharmacokinetics, Detoxication, and Consequences—Cyp1 Knockout Mouse Lines as a Paradigm (2013) (116)
- Human AH locus polymorphism and cancer: inducibility of CYP1A1 and other genes by combustion products and dioxin. (1991) (115)
- Benzo[a]pyrene-induced toxicity: paradoxical protection in Cyp1a1(-/-) knockout mice having increased hepatic BaP-DNA adduct levels. (2001) (113)
- Discovery of ZIP transporters that participate in cadmium damage to testis and kidney. (2009) (113)
- Hepatocyte‐specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure (2007) (113)
- Regulation of mouse CYP1A1 gene expression by dioxin: requirement of two cis-acting elements during induction (1989) (112)
- Tissue- and cell type-specific expression of cytochrome P450 1A1 and cytochrome P450 1A2 mRNA in the mouse localized in situ hybridization. (1999) (111)
- COVID-19 vulnerability: the potential impact of genetic susceptibility and airborne transmission (2020) (110)
- Transgenic Zebrafish as Sentinels for Aquatic Pollution (2000) (110)
- Enhanced cadmium-induced testicular necrosis and renal proximal tubule damage caused by gene-dose increase in a Slc39a8-transgenic mouse line. (2007) (109)
- Extreme discordant phenotype methodology: an intuitive approach to clinical pharmacogenetics. (2000) (108)
- From Human Genetics and Genomics to Pharmacogenetics and Pharmacogenomics: Past Lessons, Future Directions (2008) (106)
- The Ah regulatory gene product. Survey of nineteen polycyclic aromatic compounds' and fifteen benzo[a]pyrene metabolites' capacity to bind to the cytosolic receptor. (1982) (104)
- Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of Cyp1 enzymes (2013) (103)
- Ten nucleotide differences, five of which cause amino acid changes, are associated with the Ah receptor locus polymorphism of C57BL/6 and DBA/2 mice. (1993) (101)
- Glutamate-cysteine ligase modifier subunit: mouse Gclm gene structure and regulation by agents that cause oxidative stress. (2002) (100)
- Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2. (2005) (100)
- Mutations affecting the regulation of transcription of the cytochrome P1-450 gene in the mouse Hepa-1 cell line. (1985) (100)
- Aryl hydrocarbon hydroxylase induction in mammalian liver-derived cell cultures. Stimulation of "cytochrome P1-450-associated" enzyme activity by many inducing compounds. (1975) (99)
- Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype (2006) (98)
- The Ah locus, a multigene family necessary for survival in a chemically adverse environment: comparison with the immune system. (1982) (96)
- ZIP8 Zinc Transporter: Indispensable Role for Both Multiple-Organ Organogenesis and Hematopoiesis In Utero (2012) (94)
- Mouse cytosolic class 3 aldehyde dehydrogenase (Aldh3a1): gene structure and regulation of constitutive and dioxin-inducible expression. (1999) (94)
- Purification and characterization of heterologously expressed mouse CYP2A5 and CYP2G1: role in metabolic activation of acetaminophen and 2,6-dichlorobenzonitrile in mouse olfactory mucosal microsomes. (1998) (92)
- Transcription factors and cancer: an overview. (2002) (91)
- Advances in pharmacogenomics and individualized drug therapy: exciting challenges that lie ahead. (2004) (90)
- Role of CYP1A2 in the hepatotoxicity of acetaminophen: investigations using Cyp1a2 null mice. (1998) (90)
- Protection of the Cyp1a2(-/-) null mouse against uroporphyria and hepatic injury following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. (2001) (89)
- Genetic expression of aryl hydrocarbon hydroxylase induction. Evidence for the involvement of other genetic loci. (1974) (88)
- Evolutionary divergence and functions of the ADAM and ADAMTS gene families (2009) (88)
- Update of human and mouse matrix metalloproteinase families (2010) (85)
- Suggestions for the nomenclature of human alleles: relevance to ecogenetics, pharmacogenetics and molecular epidemiology. (2000) (85)
- Toward the evaluation of function in genetic variability: Characterizing human SNP frequencies and establishing BAC‐transgenic mice carrying the human CYP1A1_CYP1A2 locus (2005) (85)
- Genetic differences in microsomal electron transport: the Ah locus. (1978) (84)
- Genetic differences in induction of cytosol reduced-NAD(P):menadione oxidoreductase and microsomal aryl hydrocarbon hydroxylase in the mouse. (1977) (84)
- Cytosolic receptor for aryl hydrocarbon hydroxylase induction by polycyclic aromatic compounds. Evidence for structural and regulatory variants among established cell cultured lines. (1977) (83)
- TCDD decreases ATP levels and increases reactive oxygen production through changes in mitochondrial F(0)F(1)-ATP synthase and ubiquinone. (2006) (83)
- Genetic differences in the extent of aryl hydrocarbon hydroxylase induction in mouse fetal cell cultures. (1970) (83)
- Pharmacogenomics and “Individualized Drug Therapy” (2003) (82)
- Regulatory gene product of the Ah complex. Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methylcholanthrene binding to several moieties in mouse liver cytosol. (1981) (81)
- Cytochrome P450 gene expression and regulation (1985) (80)
- P450 gene nomenclature based on evolution. (1991) (80)
- Evidence in rat and mouse liver for temporal control of two forms of cytochrome P-450 inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin. (1978) (80)
- Assignment of the human 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 gene to chromosome 15. (1985) (80)
- Aryl hydrocarbon hydroxylase induction in human lymphocyte cultures by 2,3,7,8-tetrachlorodibenzo-p-dioxin. (1974) (79)
- Xenobiotic-metabolizing Cytochromes P450 Convert Prostaglandin Endoperoxide to Hydroxyheptadecatrienoic Acid and the Mutagen, Malondialdehyde* (2000) (77)
- 2,3,7,8-tetrachlorodibenzo-p-dioxin as cocarcinogen causing 3-methylcholanthrene-initiated subcutaneous tumors in mice genetically "nonresponsive" at Ah locus. (1978) (77)
- Aryl hydrocarbon hydroxylase induction in mammalian liver cell culture. I. Stimulation of enzyme activity in nonhepatic cells and in hepatic cells by phenobarbital, polycyclic hydrocarbons, and 2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane. (1971) (77)
- The role of ribonucleic acid and protein synthesis in microsomal aryl hydrocarbon hydroxylase induction in cell culture. The independence of transcription and translation. (1970) (77)
- Pharmacogenomics and "individualized drug therapy": high expectations and disappointing achievements. (2003) (76)
- Induction of Aryl Hydrocarbon Hydroxylase Activity in Various Cell Cultures by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (1975) (76)
- Uroporphyria produced in mice by iron and 5-aminolaevulinic acid does not occur in Cyp1a2(-/-) null mutant mice. (1998) (75)
- 4-aminobiphenyl-induced liver and urinary bladder DNA adduct formation in Cyp1a2(-/-) and Cyp1a2(+/+) mice. (2003) (74)
- Comparison of the flanking regions and introns of the mouse 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 and P3-450 genes. (1985) (74)
- From human genetics and genomics to pharmacogenetics and pharmacogenomics: past lessons, future directions. (2008) (74)
- Human cytochrome P450 (CYP) genes: recommendations for the nomenclature of alleles. (2000) (73)
- Tentative identification of benzo[a]pyrene metabolite-nucleoside complexes produced in vitro by mouse liver microsomes. (1978) (73)
- CHAPTER 7 – The Ah Receptor: Controlling Factor in the Induction of Drug-Metabolizing Enzymes by Certain Chemical Carcinogens and Other Environmental Pollutants (1983) (73)
- Genetic evidence for many unique liver microsomal P-450-mediated monooxygenase activities in heterogeneic stock mice. (1981) (72)
- Genetically mediated induction of drug-metabolizing enzymes associated with congenital defects in the mouse. (1977) (72)
- Role of cytochrome p4501 family members in the metabolic activation of polycyclic aromatic hydrocarbons in mouse epidermis. (2004) (72)
- Human Ah receptor (AHR) gene: localization to 7p15 and suggestive correlation of polymorphism with CYP1A1 inducibility. (1997) (72)
- NAD(P)H:menadione oxidoreductase. Novel purification of enzyme cDNA and complete amino acid sequence, and gene regulation. (1986) (72)
- Cytochrome P450: evolution and functional diversity. (1994) (71)
- How knockout mouse lines will be used to study the role of drug-metabolizing enzymes and their receptors during reproduction and development, and in environmental toxicity, cancer, and oxidative stress. (1997) (71)
- Genetic expression of aryl hydrocarbon hydroxylase induction. Presence or absence of association with zoxazolamine, diphenylhydantoin, and hexobarbital metabolism. (1974) (69)
- A sensitive radiometric assay of aminopyrine N-demethylation. (1973) (69)
- Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily (2011) (68)
- Structural gene products of the Ah locus. Evidence for many unique P-450-mediated monooxygenase activities reconstituted from 3-methylcholanthrene-treated C57BL/6N mouse liver microsomes. (1981) (68)
- Structural gene product of the [Ah] complex. Evidence for transcriptional control of cytochrome P1-450 induction by use of a cloned DNA sequence. (1981) (68)
- Human P3450: cDNA and complete amino acid sequence (1986) (67)
- Generation of 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-) mouse line. (2007) (67)
- Pharmacogenomics, ethnicity, and susceptibility genes (2001) (67)
- Correlation of type I, type II, and reverse type I difference spectra with absolute changes in spin state of hepatic microsomal cytochrome P-450 iron from five mammalian species. (1978) (66)
- Basal and inducible CYP1 mRNA quantitation and protein localization throughout the mouse gastrointestinal tract. (2008) (66)
- Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2. (2012) (65)
- Genetic polymorphisms in human drug-metabolizing enzymes: potential uses of reverse genetics to identify genes of toxicological relevance. (1997) (65)
- The murine Cyp1a-1 gene negatively regulates its own transcription and that of other members of the aromatic hydrocarbon-responsive [Ah] gene battery. (1990) (63)
- Comparison of aryl hydrocarbon hydroxylase and acetanilide 4-hydroxylase induction by polycyclic aromatic compounds in human and mouse cell lines. (1985) (62)
- Human aldehyde dehydrogenase genes: alternatively spliced transcriptional variants and their suggested nomenclature (2009) (62)
- Characterization of the MTF-1 transcription factor from zebrafish and trout cells. (2000) (62)
- Genetic regulation of aryl hydrocarbon hydroxylase induction in the mouse. (1972) (62)
- Evolutionary divergence and functions of the human acyl-CoA thioesterase gene (ACOT) family (2010) (62)
- Human cytochrome P-450 (CYP) genes: a web page for the nomenclature of alleles. (2001) (62)
- Drug metabolic enzymes in developmental toxicology. (1996) (61)
- Differential regulation of mouse Ah receptor gene expression in cell lines of different tissue origins. (1996) (61)
- Electrofocusing of integral membrane proteins in mixtures of zwitterionic and nonionic detergents. (1979) (60)
- Isolation and characterization of full-length mouse cDNA and genomic clones of 3-methylcholanthrene-inducible cytochrome P1-450 and P3-450. (1984) (60)
- Inhibition of CYP1A1 enzyme activity in mouse hepatoma cell culture by soybean isoflavones. (1999) (59)
- Recommendations for locus‐specific databases and their curation (2008) (59)
- Phenotype of the Cyp1a1/1a2/1b1(-/-) Triple-Knockout Mouse (2008) (59)
- Genetic differences in susceptibility to chemically induced myelotoxicity and leukemia. (1981) (58)
- CYP1A2 is essential in murine uroporphyria caused by hexachlorobenzene and iron. (2000) (58)
- Genetic differences in aryl hydrocarbon hydroxylase induction and benzo(a)pyrene-produced tumorigenesis in the mouse. (1973) (58)
- Association between DNA variant sites in the apolipoprotein A5 gene and coronary heart disease in Chinese. (2005) (58)
- Perturbation of the mitosis/apoptosis balance: a fundamental mechanism in toxicology. (1997) (58)
- Lipid metabolism and body composition in Gclm(-/-) mice. (2011) (58)
- Interaction between the Ah receptor and proteins binding to the AP-1-like electrophile response element (EpRE) during murine phase II [Ah] battery gene expression. (1995) (57)
- Uncoupling-mediated generation of reactive oxygen by halogenated aromatic hydrocarbons in mouse liver microsomes. (2004) (57)
- Statistical power of association using the extreme discordant phenotype design (2006) (56)
- Drug-Metabolizing Enzymes, Polymorphisms and Interindividual Response to Environmental Toxicants (2000) (56)
- Aryl hydrocarbon hydroxylase, epoxide hydrase, and 7,12-dimethylbenz(a)anthracene-produced skin tumorigenesis in the mouse. (1972) (55)
- Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. Distinction between the "responsive" homozygote and heterozygote at the Ah locus. (1975) (55)
- The Ah receptor: binding specificity only for foreign chemicals? (1984) (55)
- The human dioxin-inducible NAD(P)H: quinone oxidoreductase cDNA-encoded protein expressed in COS-1 cells is identical to diaphorase 4. (1991) (54)
- Organ-Specific Roles of CYP1A1 during Detoxication of Dietary Benzo[a]pyrene (2010) (54)
- Activation of transcription factors in zebrafish cell cultures by environmental pollutants. (2000) (54)
- Aryl hydrocarbon hydroxylase induction in mammalian liver cell culture. 3. Effects of various sera, hormones, biogenic amines, and other endogenous compounds on the enzyme activity. (1972) (53)
- Comparison of mouse hepatic mitochondrial versus microsomal cytochromes P450 following TCDD treatment. (2006) (53)
- Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse. (1998) (53)
- “Gene‐Swap Knock‐in” Cassette in Mice to Study Allelic Differences in Human Genes (2000) (53)
- Aryl hydrocarbon hydroxylase induction in mammalian liver cell culture. II. Effects of actinomycin D and cycloheximide on induction processes by phenobarbital or polycyclic hydrocarbons. (1971) (53)
- Genetic expression of aryl hydrocarbon hydroxylase induction. Genetic specificity resides in the fraction containing cytochromes P448 and P450. (1973) (53)
- Isolation and characterization of a cloned DNA sequence associated with the murine Ah locus and a 3-methylcholanthrene-induced form of cytochrome P-450. (1981) (53)
- The in vitro metabolism and convalent binding of benzo[a]pyrene to DNA catalysed by trout liver microsomes. (1979) (53)
- Genetic association of increases in naphthalene, acetanilide, and biphenyl hydroxylations with inducible aryl hydrocarbon hydroxylase in mice. (1976) (52)
- Regulation of mouse cytochrome P3-450 by the Ah receptor. Studies with a P3-450 cDNA clone. (1984) (52)
- Effects of cytochrome P1-450 inducers on the cell-surface receptors for epidermal growth factor, phorbol 12,13-dibutyrate, or insulin of cultured mouse hepatoma cells. (1983) (52)
- Mouse cytochrome P3-450: complete cDNA and amino acid sequence. (1984) (52)
- Structural gene products of the Ah complex. Increases in large mRNA from mouse liver associated with cytochrome P1-450 induction by 3-methylcholanthrene. (1981) (51)
- Cyp1a2 protects against reactive oxygen production in mouse liver microsomes. (2004) (51)
- Genetic differences in the induction of monooxygenase activities by polycyclic aromatic compounds (1979) (51)
- Regulation of [Ah] gene battery enzymes and glutathione levels by 5,10-dihydroindeno[1,2-b]indole in mouse hepatoma cell lines. (1994) (50)
- Human cytochromes P 450 in health and disease (2012) (50)
- Genetic expression of aryl hydrocarbon hydroxylase induction. VI. Control of other aromatic hydrocarbon-inducible mono-oxygenase activities at or near the same genetic locus. (1973) (50)
- Isolation, sequence, and developmental expression of rat UGT2B2: the gene encoding a constitutive UDP glucuronosyltransferase that metabolizes etiocholanolone and androsterone. (1991) (50)
- Microsomal Hydroxylase Induction in Liver Cell Culture by Phenobarbital, Polycyclic Hydrocarbons, and p,p'-DDT (1971) (50)
- Contributions of the Three CYP1 Monooxygenases to Pro-Inflammatory and Inflammation-Resolution Lipid Mediator Pathways (2013) (49)
- Growth signal pathways (1990) (49)
- ZIP14 and ZIP8 zinc/bicarbonate symporters in Xenopus oocytes: characterization of metal uptake and inhibition. (2012) (49)
- Altered regulation of P-450IA1 expression in a multidrug-resistant MCF-7 human breast cancer cell line. (1988) (49)
- For Dioxin-induced Birth Defects, Mouse or Human CYP1A2 in Maternal Liver Protects whereas Mouse CYP1A1 and CYP1B1 Are Inconsequential* (2006) (48)
- Developmental and tissue-specific differential regulation of the mouse dioxin-inducible P1-450 and P3-450 genes. (1985) (48)
- Dioxin-inducible enhancer region upstream from the mouse P(1)450 gene and interaction with a heterologous SV40 promoter. (1986) (48)
- Update on the human and mouse lipocalin (LCN) gene family, including evidence the mouse Mup cluster is result of an “evolutionary bloom” (2019) (47)
- The Y-box Motif Mediates Redox-dependent Transcriptional Activation in Mouse Cells (*) (1995) (47)
- Analysis of human CYP1A1 and CYP1A2 genes and their shared bidirectional promoter in eight world populations (2010) (47)
- SLC39A8 gene encoding a metal ion transporter: discovery and bench to bedside (2019) (47)
- Separation of acetanilide and its hydroxylated metabolites and quantitative determination of "acetanilide 4-hydroxylase activity" by high-pressure liquid chromatography. (1979) (46)
- Genetic regulation of aryl hydrocarbon hydroxylase induction. V. Specific changes in spin state of cytochrome P 450 from genetically responsive animals. (1973) (46)
- Ontogenetic expression of regulatory and structural gene products associated with the Ah locus. Comparison of rat, mouse, rabbit and Sigmoden hispedis. (1980) (45)
- In Utero and Lactational Exposure to PCBs in Mice: Adult Offspring Show Altered Learning and Memory Depending on Cyp1a2 and Ahr Genotypes (2011) (45)
- Can personalized drug therapy be achieved? A closer look at pharmaco-metabonomics. (2006) (45)
- Genetic expression of aryl hydrocarbon hydroxylase induction. 3. Changes in the binding of n-octylamine to cytochrome P-450. (1972) (45)
- Oral benzo[a]pyrene‐induced cancer: Two distinct types in different target organs depend on the mouse Cyp1 genotype (2010) (44)
- Genetically regulated aryl hydrocarbon hydroxylase induction in the eye: possible significance of the drug-metabolizing enzyme system for the retinal pigmented epithelium-choroid. (1975) (44)
- Negative regulation of the murine cytosolic aldehyde dehydrogenase-3 (Aldh-3c) gene by functional CYP1A1 and CYP1A2 proteins. (1992) (44)
- Mice deficient in the gene for cytochrome P450 (CYP)1A1 are more susceptible than wild-type to hyperoxic lung injury: evidence for protective role of CYP1A1 against oxidative stress. (2014) (44)
- Clinical pharmacology. Possible clinical importance of genetic differences in drug metabolism. (1981) (44)
- Enzyme induction by L-buthionine (S,R)-sulfoximine in cultured mouse hepatoma cells. (1995) (43)
- 21 – The Ah Locus: Genetic Regulation of the Enzymes which Metabolize Polycyclic Hydrocarbons and the Risk for Cancer (1978) (43)
- Role of cytochrome P450 1A2 in bilirubin degradation Studies in Cyp1a2 (-/-) mutant mice. (2001) (43)
- Markedly increased constitutive CYP1A1 mRNA levels in the fertilized ovum of the mouse. (1998) (43)
- Perturbation of the mitosis/apoptosis balance: A fundamental mechanism in toxicology (1997) (42)
- Role of P450 1A1 and P450 1A2 in bioactivation versus detoxication of the renal carcinogen aristolochic acid I: studies in Cyp1a1-/-, Cyp1a2-/-, and Cyp1a1/1a2-/- mice. (2011) (42)
- P450 genes: evolution, regulation, and relationship to human cancer and pharmacogenetics. (1986) (42)
- AN ELECTRON SPIN RESONANCE STUDY OF NEOPLASMS. (1963) (42)
- Generation of a Slc39a8 hypomorph mouse: markedly decreased ZIP8 Zn²⁺/(HCO₃⁻)₂ transporter expression. (2011) (41)
- Mouse microsomal Class 3 aldehyde dehydrogenase: AHD3 cDNA sequence, inducibility by dioxin and clofibrate, and genetic mapping. (1996) (40)
- Differential induction of murine Ah locus-associated monooxygenase activities in rabbit liver and kidney. (1975) (40)
- Interaction between the catalytic and modifier subunits of glutamate-cysteine ligase. (2007) (40)
- Elevated estrogen 16 alpha-hydroxylase activity: is this a genotoxic or nongenotoxic biomarker in human breast cancer risk? (1993) (40)
- Pharmacogenetics: 65 candles on the cake (1997) (40)
- Theophylline pharmacokinetics: comparison of Cyp1a1(−/−) and Cyp1a2(−/−) knockout mice, humanized hCYP1A1_1A2 knock-in mice lacking either the mouse Cyp1a1 or Cyp1a2 gene, and Cyp1(+/+) wild-type mice (2005) (39)
- Knock-In Mouse Lines Expressing either Mitochondrial or Microsomal CYP1A1: Differing Responses to Dietary Benzo[a]pyrene as Proof of Principle (2009) (39)
- Characterization of cytochrome P2-450 (20-S) mRNA. Association with the P1-450 genomic gene and differential response to the inducers 3-methylcholanthrene and isosafrole. (1983) (38)
- Marked increases in hepatic NAD(P)H:oxidoreductase gene transcription and mRNA levels correlated with a mouse chromosome 7 deletion. (1989) (38)
- Pharmacogenomics: out of the lab and into the community. (2001) (38)
- Genetic differences in alcohol drinking preference between inbred strains of mice. (1997) (37)
- Pharmacogenetics: an approach to understanding chemical and biologic aspects of cancer. (1980) (37)
- Applying new biotechnologies to the study of occupational cancer--a workshop summary. (2004) (37)
- Mouse dioxin-inducible cytosolic aldehyde dehydrogenase-3: AHD4 cDNA sequence, genetic mapping, and differences in mRNA levels. (1993) (36)
- Cytochrome P450 1A1 (CYP1A1) protects against nonalcoholic fatty liver disease caused by Western diet containing benzo[a]pyrene in mice. (2018) (36)
- Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences in the 3' nontranslated region, and localization of gene to chromosome 15. (1987) (36)
- Structural gene products of the murine Ah complex. Differences in ontogenesis and glucosamine incorporation between liver microsomal cytochromes P1-450 and P-448 induced by polycyclic aromatic compounds. (2005) (36)
- Quantitation of hepatic cytochrome P1-450 mRNA with the use of a cloned DNA probe. Effects of various P-450 inducers in C57BL/6N and DBA/2N mice. (1982) (35)
- Stable expression of mouse Cyp1a1 and human CYP1A2 cDNAs transfected into mouse hepatoma cells lacking detectable P450 enzyme activity. (1990) (35)
- Regulation of mouse Ah receptor (Ahr) gene basal expression by members of the Sp family of transcription factors. (1998) (35)
- Association of fertility, fitness and longevity with the murine Ah locus among (C57BL/6N) (C3H/HeN) recombinant inbred lines. (1984) (35)
- Stimulation of Aryl Hydrocarbon Hydroxylase Induction in Cell Cultures by Interferon (1973) (35)
- Cell-specific induction of mouse Cyp1a1 mRNA during development. (1989) (34)
- Nomenclature for alleles of the cytochrome P450 oxidoreductase gene. (2009) (34)
- Microsomal aryl hydrocarbon hydroxylase in rat adrenal: regulation by ACTH but not by polycyclic hydrocarbons. (1979) (33)
- Isosafrole-induced cytochrome P2-450 in DBA/2N mouse liver. Characterization and genetic control of induction. (1984) (33)
- Biological effects of the Sudan dyes. Role of the Ah cytosolic receptor. (1983) (33)
- Personalized medicine: Genetic risk prediction of drug response (2017) (33)
- Further studies on genetically mediated differences in monooxygenase activities and spin state of cytochrome P450 iron from rabbit, rat, and mouse liver. (1973) (33)
- Binding of polycyclic aromatic hydrocarbons to DNA: comparison with mutagenesis and tumorigenesis. (1980) (32)
- Inter-individual susceptibility to environmental toxicants--a current assessment. (2005) (32)
- Aromatic hydrocarbon receptor polymorphism: development of new methods to correlate genotype with phenotype. (1998) (32)
- Interaction of the regulatory domains of the murine Cyp1a1 gene with two DNA-binding proteins in addition to the Ah receptor and the Ah receptor nuclear translocator (ARNT). (1994) (31)
- Role of Protein Kinase C-mediated Protein Phosphorylation in Mitochondrial Translocation of Mouse CYP1A1, Which Contains a Non-canonical Targeting Signal* (2006) (31)
- Genes encoding drug-metabolizing enzymes: possible role in human disease. (1988) (31)
- Inducible monooxygenase activities and 3-methyl-cholanthrene-initiated tumorigenesis in mouse recombinant inbred sublines. (1976) (31)
- Pyrolysis products from amino acids and protein: highest mutagenicity requires cytochrome P1-450. (1979) (31)
- Purification and characterization of a microsomal cytochrome P‐450 with high activity of coumarin 7‐hydroxylase from mouse lives (1984) (30)
- Pharmacogenetics in clinical pharmacology and toxicology. (1995) (30)
- Localization of cytochrome P1-450 and P3-450 genes to mouse chromosome 9. (1984) (30)
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin: covalent binding of reactive metabolic intermediates principally to protein in vitro. (1979) (30)
- 1462V mutation in the human CYP1A1 gene: lack of correlation with either the Msp I 1.9 kb (M2) allele or CYP1A1 inducibility in a three-generation family of east Mediterranean descent. (1994) (29)
- Effects of microsomal enzyme inducers in vivo and inhibitors in vitro on the covalent binding of benzo[a]pyrene metabolites to DNA catalyzed by liver microsomes from genetically responsive and nonresponsive mice. (1979) (29)
- Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). (2006) (29)
- Tissue-Specific Induction of Mouse ZIP8 and ZIP14 Divalent Cation/Bicarbonate Symporters by, and Cytokine Response to, Inflammatory Signals (2014) (29)
- Mouse dioxin-inducible NAD(P)H: menadione oxidoreductase: NMO1 cDNA sequence and genetic differences in mRNA levels. (1994) (29)
- CYP1A1 and CYP1A2 expression: comparing 'humanized' mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines. (2009) (29)
- Update on genome completion and annotations: Protein Information Resource (2004) (29)
- Evolution of the P450 gene superfamily. (1988) (28)
- Formation of benzo[a]pyrene metabolite-nucleoside adducts in isolated perfused rat and mouse liver and in mouse lung slices. (1979) (28)
- NADPH-cytochrome P-450 reductase: preferential inhibition by ellipticine and other type II compounds having little effect on NADPH-cytochrome c reductase. (1980) (28)
- Naphthalene toxicity in mice and aryl hydrocarbon receptor-mediated CYPs. (2006) (28)
- Improved drug therapy: triangulating phenomics with genomics and metabolomics (2014) (28)
- Uroporphyria in mice: Thresholds for hepatic CYP1A2 and iron (2002) (28)
- Decreased Hnf-1 gene expression in mice homozygous for a 1.2-centiMorgan deletion on chromosome 7. (1990) (27)
- The DNA binding of benzo[alpha]pyrene metabolites catalysed by rat lung microsomes in vitro and in isolated perfused rat lung. (1979) (27)
- "Oxidative stress" response in liver of an untreated newborn mouse having a 1.2-centimorgan deletion on chromosome 7. (1992) (27)
- Regional linkage analysis of the dioxin-inducible P-450 gene family on mouse chromosome 9. (1985) (27)
- Cytochrome P450 (CYP) Gene Superfamily (2011) (27)
- Aryl hydrocarbon receptor ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin enhances liver damage in bile duct-ligated mice. (2011) (27)
- Possible Role of Cytochromes P450 in Lupus Erythematosus and Related Disorders (1994) (26)
- Proposal for an allele nomenclature system based on the evolutionary divergence of haplotypes (2002) (26)
- Expression of the mouse P(1)450 gene during differentiation without foreign chemical stimulation. (1987) (26)
- Early onset senescence occurs when fibroblasts lack the glutamate-cysteine ligase modifier subunit. (2009) (26)
- Identification of genetic differences in drug metabolism: Prediction of individual risk of toxicity or cancer (1991) (26)
- Novel P143L polymorphism of the LCAT gene is associated with dyslipidemia in Chinese patients who have coronary atherosclerotic heart disease. (2004) (26)
- The AP-1 site and the cAMP- and serum response elements of the c-fos gene are constitutively occupied in vivo. (1991) (25)
- Oral N-acetylcysteine rescues lethality of hepatocyte-specific Gclc-knockout mice, providing a model for hepatic cirrhosis. (2010) (25)
- Genetic control of carcinogen metabolism leading to individual differences in cancer risk (1978) (25)
- Murine mdr-1, mdr-2, and mdr-3 gene expression: no coinduction with the Cyp1a-1 and Nmo-1 genes in liver by 2,3,7,8-tetrachlorodibenzo-p-dioxin. (1991) (25)
- The 1986 Bernard B. Brodie award lecture. The genetic regulation of drug-metabolizing enzymes. (1988) (25)
- Use of fetal cell culture as an experimental system for predicting drug metabolism in the intact animal (1973) (24)
- Genetic differences in phenytoin pharmacokinetics. In vivo clearance and in vitro metabolism among inbred strains of mice. (1980) (24)
- Manganese accumulation in the mouse ear following systemic exposure (2008) (24)
- Pharmacological rescue of the 14CoS/14CoS mouse: hepatocyte apoptosis is likely caused by endogenous oxidative stress. (2003) (24)
- Fate of inducer during induction of aryl hydrocarbon hydroxylase activity in mammalian cell culture. I. Intracellular entry, binding, distribution, and metabolism. (1970) (24)
- Effects of environmental chemicals on the genetic regulation of microsomal enzyme systems (1977) (24)
- Aryl hydrocarbon hydroxylase induction in mammalian liver-derived cell cultures. Effects of various metabolic inhibitors on the enzyme activity in hepatoma cells. (1976) (24)
- Decrease in 4-aminobiphenyl-induced methemoglobinemia in Cyp1a2(-/-) knockout mice. (2002) (24)
- Expression of aryl hydrocarbon hydroxylase induction and suppression of tyrosine aminotransferase induction in somatic-cell hybrids. (1972) (23)
- NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I. (2012) (23)
- Genetic architecture of susceptibility to PCB126-induced developmental cardiotoxicity in zebrafish. (2011) (23)
- Glutathione-deficient mice are susceptible to TCDD-Induced hepatocellular toxicity but resistant to steatosis. (2012) (23)
- Response of [Ah] battery genes to compounds that protect against menadione toxicity. (1995) (23)
- Protective role of cytochrome P450 1A1 (CYP1A1) against benzo[a]pyrene-induced toxicity in mouse aorta. (2014) (23)
- Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins. (2013) (22)
- Genetic risk prediction: individualized variability in susceptibility to toxicants. (2013) (22)
- Similarities between mouse and rat-liver microsomal cytochromes P-450 induced by 3-methylcholanthrene. Evidence from catalytic, immunologic, and recombinant DNA studies. (1982) (22)
- Spectral evidence for weak ligand in sixth position of hepatic microsomal cytochrome P-450 low spin ferric iron in vivo. (1978) (22)
- P450 genes and evolutionary genetics. (1987) (22)
- Hyperfine Structure in the EPR Spectrum of the Manganous Ion in Frozen Solutions (1964) (22)
- Pharmacogenetics: a possible pragmatic perspective in neoplasm predictability. (1978) (21)
- Genetic differences in drug metabolism associated with ocular toxicity. (1982) (21)
- Comparing gene expression during cadmium uptake and distribution: untreated versus oral Cd-treated wild-type and ZIP14 knockout mice. (2015) (21)
- Cytochrome P1-450 structural gene in mouse, rat, and rabbit: differences in DNA methylation and developmental expression of mRNA. (1982) (20)
- Menadione toxicity in two mouse liver established cell lines having striking genetic differences in quinone reductase activity and glutathione concentrations. (1993) (20)
- Generation of a 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahrd mouse line harboring the poor-affinity aryl hydrocarbon receptor. (2008) (20)
- Trout CYP1A3 Gene: Recognition of Fish DNA Motifs by Mouse Regulatory Proteins (1999) (20)
- Cellular Responses To Oxidative Stress (1990) (19)
- cDNA and complete amino acid sequence of mouse P2(450): allelic variant of mouse P3(450) gene. (1986) (19)
- Structure of the mouse cytochrome P1-450 genomic gene. (1983) (19)
- In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes. (2011) (19)
- Oral Cadmium in Mice Carrying 5 Versus 2 Copies of the Slc39a8 Gene (2014) (19)
- CYTOCHROME P450 KNOCKOUT MICE: NEW TOXICOLOGICAL MODELS (1998) (19)
- Aryl hydrocarbon hydroxylase induction by benzo[a]anthracene: regulatory gene localized to the distal portion of mouse chromosome 17. (1984) (19)
- Genetic aspects of toxicity during development. (1976) (19)
- Tyrphostin [correction of Tryphostin] AG879, a tyrosine kinase inhibitor: prevention of transcriptional activation of the electrophile and the aromatic hydrocarbon response elements. (2001) (19)
- Subcellular events occurring during aryl hydrocarbon hydroxylase induction: no requirement for metabolism of polycyclic hydrocarbon inducer. (1977) (19)
- A novel allele in the promoter of the hepatic lipase is associated with increased concentration of HDL-C and decreased promoter activity DOI 10.1194/jlr.M200046-JLR200 (2002) (18)
- Effect of chronic glutathione deficiency on the behavioral phenotype of Gclm-/- knockout mice. (2012) (18)
- Zinc- and bicarbonate-dependent ZIP8 transporter mediates selenite uptake (2016) (18)
- 7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes. (2007) (18)
- Genetic Differences in Benzo[a]pyrene Carcinogenic Index in Vivo and in Mouse Cytochrome P1 450-Mediated Benzo[a]pyrene Metabolite Binding to DNA in Vitro (1977) (18)
- Ecogenetics: From Ecology To Health (1997) (17)
- Chapter 3 – Human Genetic Variation in the Enzymes of Detoxication (1980) (17)
- The Ah locus: aromatic hydrocarbon responsiveness... of mice and men. (1978) (17)
- Aryl hydrocarbon hydroxylase inducibility among primary relatives of children with leukemia or solid tumors. (1984) (17)
- Hepatic ZIP8 deficiency is associated with disrupted selenium homeostasis, liver pathology, and tumor formation. (2018) (17)
- Comparison of gene expression in cell culture to that in the intact animal: relevance to drugs and environmental toxicants. Focus on "development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes". (2006) (17)
- Multiple forms of inducible drug-metabolizing enzymes: A reasonable mechanism by which any organism can cope with adversity (1979) (17)
- Genetics and functions of the retinoic acid pathway, with special emphasis on the eye (2019) (17)
- Transcriptional derepression of the murine Cyp1a‐1 gene by mevinolin (1992) (16)
- Characterization of a cDNA clone for mouse phenobarbital-inducible cytochrome P-450b. (1984) (16)
- Retrovirally expressed metal response element-binding transcription factor-1 normalizes metallothionein-1 gene expression and protects cells against zinc, but not cadmium, toxicity. (2002) (16)
- Carcinogenic benzo(a)pyrene metabolites bound to DNA: metabolic formation by human cultured lymphocytes and by human liver microsomes. (1978) (15)
- Association of the Ah locus with specific changes in metyrapone and ethylisocyanide binding to mouse liver microsomes. (1976) (15)
- Fate of inducer during induction of aryl hydrocarbon hydroxylase activity in mammalian cell culture. II. Levels of intracellular polycyclic hydrocarbon during enzyme induction and decay. (1970) (15)
- Drug metabolism and signal transduction: possible role of Ah receptor and arachidonic acid cascade in protection from ethanol toxicity. (1994) (15)
- Sensitivity of CYP1A1 mRNA inducibility by dioxin is the same in Cyp1a2(+/+) wild-type and Cyp1a2(-/-) null mutant mice. (1997) (15)
- Genetic differences in metabolism of polycyclic aromatic carcinogens and aromatic amines by mouse liver microsomes. Detection by DNA binding of metabolites and by mutagenicity in histidine-dependent Salmonella typhimurium in vitro. (1979) (14)
- Overview of PAX gene family: analysis of human tissue-specific variant expression and involvement in human disease (2020) (14)
- DNA Binding of Benzo[a]pyrene Metabolites (1980) (14)
- In utero gene expression in the Slc39a8(neo/neo) knockdown mouse (2018) (14)
- Uroporphyria and hepatic carcinogenesis induced by polychlorinated biphenyls-iron interaction: absence in the Cyp1a2(-/-) knockout mouse. (2005) (13)
- Update on human genome completion and annotations: Gene nomenclature (2003) (13)
- A MICROSOMAL DIFFERENCE BETWEEN NORMAL LIVER AND "MINIMAL-DEVIATION" HEPATOMA 5123 DETECTABLE BY ELECTRON SPIN RESONANCE. (1964) (13)
- Birth defects and aplastic anemia: differences in polycyclic hydrocarbon toxicity associated with the Ah locus (1977) (13)
- Comparative EPR study on high-spin ferric porphine complexes and cytochrome P-450 having rhombic character. (1977) (13)
- THE MURINE Ah LOCUS AND DYSMORPHOGENESIS (1977) (13)
- Inbreeding and epigenetics: beneficial as well as deleterious effects (2010) (13)
- Genetic differences in the metabolism of carcinogens and in the binding of benzo (a) pyrene metabolites to DNA. (1976) (13)
- Mouse lung CYP 1 A 1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo [ 4 , 5b ] pyridine ( PhIP ) (2007) (12)
- Two RFLPs associated with the human P1450 gene linked to the MPI locus on chromosome 15 [HGM8 D15S8]. (1986) (12)
- Selective mouse breeding for short ethanol sleep time has led to high levels of hepatic aromatic hydrocarbon (Ah) receptor. (1989) (12)
- Microsomal cytochromes b5 and P450 during induction of aryl hydrocarbon hydroxylase activity in mammalian cell culture. (1970) (12)
- The murine aromatic hydrocarbon responsiveness locus: a comparison of receptor levels and several inducible enzyme activities among recombinant inbred lines. (1986) (12)
- Genetic differences in cytochrome P-450 during induction of mono-oxygenase activities. (1973) (12)
- A structured simple form for ordering genetic tests is needed to ensure coupling of clinical detail (phenotype) with DNA variants (genotype) to ensure utility in publication and databases (2007) (12)
- Comparison of oxidative stress response parameters in newborn mouse liver versus simian virus 40 (SV40)-transformed hepatocyte cell lines. (2000) (12)
- Human P3(450): cDNA and complete amino acid sequence. (1986) (12)
- Localization of UDP glucuronosyltransferase gene(s) on mouse chromosome 5 (1987) (12)
- Olfactory Receptor Gene Polymorphisms and Nonallergic Vasomotor Rhinitis (2008) (12)
- Uroporphyrin accumulation in hepatoma cells expressing human or mouse CYP1A2: relation to the role of CYP1A2 in human porphyria cutanea tarda. (2003) (11)
- Polymorphism of human CYP2D genes involved in drug metabolism: possible relationship to individual cancer risk. (1991) (11)
- Evolution of the P450 gene superfamily and regulation of the murine Cyp1a1 gene. (1990) (11)
- Possible effect of neonatal polybrominated biphenyl exposure on the developmental abilities of children. (1983) (11)
- ASSOCIATION ON TYPE I, TYPE II, AND REVERSE TYPE I DIFFERENCE SPECTRA WITH ABSOLUTE SPIN STATE OF CYTOCHROME P-450 IRON (1977) (11)
- Dibenz[a,h]anthracene-induced subcutaneous tumors in mice. Strain sensitivity and the role of carcinogen metabolism. (1983) (11)
- Multiple forms of inducible drug-metabolizing enzymes: A reasonable mechanism by which any organism can cope with adversity (2004) (11)
- Oral benzo[a]pyrene in Cyp1a1/1b1(–/–) double‐knockout mice: Microarray analysis during squamous cell carcinoma formation in preputial gland duct (2013) (11)
- Coffee, myocardial infarction, and CYP nomenclature. (2006) (10)
- Benzo[a]pyrene metabolism in mouse liver. Association of both 7,8-epoxidation and covalent binding of a metabolite of the 7,8-diol with the Ah locus. (1985) (10)
- Single-nucleotide polymorphisms in the lipoprotein lipase gene associated with coronary heart disease in Chinese. (2002) (10)
- Given the complexity of the human genome, can 'personalised medicine' or 'individualised drug therapy' ever be achieved? (2009) (10)
- Human Cytochrome P-450 (CYP) Genes (2001) (10)
- Update of the keratin gene family: evolution, tissue-specific expression patterns, and relevance to clinical disorders (2022) (10)
- Mouse class 3 aldehyde dehydrogenases: positive and negative regulation of gene expression. (1993) (10)
- Genetic differences in lethality of newborn mice treated in utero with coplanar versus non-coplanar hexabromobiphenyl. (2006) (10)
- Subcellular localization of membrane-bound aryl-hydrocarbon hydroxylase and NAD(P)H-dependent reductase activities in mouse liver. (1980) (9)
- Variations in Aryl Hydrocarbon Hydroxylase Activities in Mitogen-Activated Human and Nonhuman Primate Lymphocytes (1984) (9)
- A single gene difference in early death caused by hypoplastic anemia in mice receiving oral benzo[a]pyrene daily (1975) (9)
- Phospholipase A2 activation and increases in specific prostaglandins in the oxidatively stressed 14CoS/14CoS mouse hepatocyte line. (1998) (9)
- Methylation differences in the murine P1450 and P3450 genes in wild-type and mutant hepatoma cell culture. (1986) (9)
- Genetic control of drug metabolism: relationship to birth defects. (1982) (8)
- Dioxin-induced birth defects : mouse or human CYP 1 A 2 in maternal liver protects , whereas mouse CYP 1 A 1 and CYP 1 B 1 are inconsequential (2006) (8)
- A new home for Human Genomics (2012) (8)
- Mouse class 3 aldehyde dehydrogenases. (1995) (8)
- Changes in aryl hydrocarbon hydroxylase activity and microsomal P450 during polycyclic hydrocarbon treatment of mammalian cells in culture. (1969) (8)
- Induction of immunotoxicity by polycyclic hydrocarbons: Role of the Ah locus (1984) (8)
- DRUGS AND MICROSOMAL ENZYME FORMATION IN VIVO AND IN MAMMALIAN CELL CULTURE (1969) (8)
- Balancer-Cre transgenic mouse germ cells direct the incomplete resolution of a tri-loxP-targeted Cyp1a1 allele, producing a conditional knockout allele. (2003) (7)
- An investigation of genetic variation within a series of congenic strains of mice (1984) (7)
- Relative roles of CYP2E1 and CYP1A2 in mouse uroporphyria caused by acetone. (2000) (7)
- Cyclophilin nomenclature problems, or, 'a visit from the sequence police' (2004) (7)
- Expression of the chloramphenicol acetyltransferase (CAT) reporter gene by the murine Cyp1a-2 (cytochrome P3(450)) promoter in hepatoma cell cultures. (1990) (7)
- Aryl hydrocarbon hydroxylase induction in cell culture as a function of gene expression. (1971) (7)
- Update on human genome completion and annotations: Protein information resource (2004) (6)
- Circular dichroism studies on the binding of type I substrates and reverse type I compounds to rabbit liver microsomal cytochrome P-450. (1978) (6)
- Aryl Hydrocarbon Hydroxylase Activity “Of Mice and Humans” (1983) (6)
- Association between susceptibility to dibenzanthracene‐induced fibrosarcoma formation and the Ah locus (1983) (6)
- The Ah locus. A gene with possible importance in cancer predictability. (1980) (6)
- Use of reporter genes and vertebrate DNA motifs in transgenic zebrafish as sentinels for assessing aquatic pollution. (2002) (6)
- An example of P-450 catalytic activities not correlated with corresponding P-450 mRNA concentrations. (1986) (6)
- Pharmacogenetics and Pharmacogenomics (2006) (5)
- Genetic control of drug metabolism. (1978) (5)
- Lack of response of the rat liver "class 3" cytosolic aldehyde dehydrogenase to toxic chemicals, glutathione depletion, and other forms of stress. (1994) (5)
- Update of the human and mouse Fanconi anemia genes (2015) (5)
- Drug metabolism. Growth signal pathways. (1990) (5)
- Current cellular assays for measuring clinical drug metabolizing capacity--impact of new molecular biologic techniques. (1986) (5)
- Hypoproteinemia and cystic fibrosis. (1966) (5)
- Developmental pharmacology and the Ah locus: regulatory and temporal genes affecting teratogenesis. (1979) (5)
- Genetic Differences in Enzymes which Metabolize Drugs, Chemical Carcinogens, and Other Environmental Pollutants (1983) (5)
- Aldehyde dehydrogenase (ALDH) superfamily in plants: gene nomenclature and comparative genomics (2012) (5)
- Purification and characterization of a microsomal cytochrome P-450 with high activity of coumarin 7-hydroxylase from mouse liver. (1984) (5)
- Corrigendum to “Advances in pharmacogenomics and individualized drug therapy: exciting challenges that lie ahead” [Eur. J. Pharmacol. 500 (2004) 267–280] (2005) (4)
- Structural gene products of the murine ah locus: immunochemical evidence for two forms of liver p-450 induced by 3-methylcholanthrene. Abstr. (1979) (4)
- Role of molecular biology in risk assessment. (1996) (4)
- Environmental and genetic factors influencing drug metabolism and toxicity (1984) (4)
- Pharmacogenetics and human cancer. (1982) (4)
- SYMPOSIUM OVERVIEW Drug Metabolic Enzymes in Developmental Toxicology1 (1996) (4)
- Head-and-neck squamous cell carcinoma risk in smokers: no association detected between phenotype and AHR, CYP1A1, CYP1A2, or CYP1B1 genotype (2016) (4)
- The truth about mouse, human, worms and yeast (2004) (4)
- Expression of benz[a]anthracene-inducible aryl hydrocarbon hydroxylase activity in mouse-hamster and mouse-human somatic-cell hybrids. (1972) (4)
- Human drug metabolism polymorphisms: use of recombinant DNA techniques. (1987) (4)
- Environmental factors influencing the hyperfine structure of manganous low-temperature electron paramagnetic resonance spectra. (1966) (4)
- Genetic Differences in Drug Metabolism: Proposed Relationship to Human Birth Defects (1983) (4)
- Comparison of the mouse P(1)450 gene and flanking sequences from a MOPC 41 plasmacytoma and normal liver. (1985) (4)
- Extrahepatic expression of NAD(P)H:menadione oxidoreductase, UDP glucuronosyltransferase-1A6, microsomal aldehyde dehydrogenase, and hepatic nuclear factor-1 alpha mRNAs in ch/ch and 14CoS/14CoS mice. (1997) (4)
- Networking nomenclature (1998) (4)
- Measurements of the cytosolic Ah receptor among four strains of Drosophila melanogaster (1985) (3)
- Role of host susceptibility to toxicity and cancer caused by pesticides: Cytochromes P450 (2005) (3)
- P450 genes and their regulation (1985) (3)
- Ornithine decarboxylase induction in liver- and hepatoma-derived cell cultures: no detectable differences between control and 3-methylcholanthrene-treated cells. (1981) (3)
- What do animal experiments tell us that in vitro systems cannot? The Human Toxome Project. (2016) (3)
- Ligands of four receptors in the nuclear steroid/thyroid hormone superfamily inhibit induction of rat cytosolic aldehyde dehydrogenase-3 (ALDH3c) by 3-methylcholanthrene. (1995) (3)
- Analysis and update of the human aldehyde dehydrogenase ( ALDH )g ene (2005) (3)
- Covalent binding of diethylstilbestrol to dna catalyzed by hepatic and uterine microsomes. Abstr. (1979) (3)
- Aryl hydrocarcon hydroxylase and tyrosine aminotransferase activities in somatic-cell hybrids derived from hepatoma tissue culture HTC (rat) cells and 3T3 (mouse) benzo(a)pyrene-resistant cells. (1974) (3)
- Perceptions of genetic research in three rural Appalachian Ohio communities (2012) (3)
- Reply to the letter of doctors Shepard and Fantel (1980) (3)
- Coffee, myocardial infarction, and CYP nomenclature. Authors' reply (2006) (3)
- Hepatic Drug-Metabolizing Enzymes during Embryonic and Fetal Development (1983) (3)
- Aryl Hydrocarbon Hydroxylase. Evidence of Receptors for Induction Process in Cell Culture (1979) (2)
- COVID-19 vulnerability: the potential impact of genetic susceptibility and airborne transmission (2020) (2)
- Drug Metabolism: Evolution (2006) (2)
- Localization of the murine Hmg1 gene, encoding an HMG-box protein, to mouse Chromosome 2 (2004) (2)
- Cloning genes that encode inducible forms of P-450. (1984) (2)
- Identification of genetic differences in debrisoquine hydroxylase activity (1992) (2)
- Hemopexin and aryl hydrocarbon hydroxylase induction in the mouse and in cell culture. (1978) (2)
- Ecogenetics: genetic susceptibility to environmental adversity (2002) (2)
- Designer Genes: A new Era in the Evolution of Man (2011) (2)
- Placing human gene families into their evolutionary context (2022) (2)
- Birth defects and the potential role of genetic differences in drug metabolism. (1981) (2)
- STRUCTURAL GENE PRODUCTS OF THE MURINE Ah LOCUS. IMMUNOCHEMICAL CHARACTERIZATION OF TWO FORMS OF P-450 INDUCED BY POLYCYCLIC AROMATIC COMPOUNDS (1980) (2)
- Changes in cytochrome P-450 iron spin state as a function of castration, testosterone or estrogen treatment, vigorous exercise, or starvation. (1984) (2)
- The importance of genetics in the metabolism and fate of mutagens and promutagens (1982) (2)
- Conflicts of Interests: Declarations for All (2004) (2)
- Update of the human and mouse SERPINgene superfamily (2013) (2)
- Pharmacogenetics, Wendell W. Weber (Ed.). Oxford University Press, New York (1997), 344, $60.00. (1997) (2)
- Effects of cimetidine on theophylline, acetaminophen, and zoxazolamine toxicity in the intact mouse. (1984) (2)
- Cloning genes that encode drug-metabolizing enzymes: developmental pharmacology and teratology. (1983) (2)
- Improved drug therapy: triangulating phenomics with genomics and metabolomics (2014) (1)
- Reply to Kalow et al (2001) (1)
- Networking nomenclature [news] (1998) (1)
- 22LA-03-2 Environmental Susceptibility Genes That Cause Toxicity and Cancer (1999) (1)
- Corrigendum to "Personalized medicine: Genetic risk prediction of drug response" [Pharmacol. Ther. 175 (2017) 75-90.]. (2018) (1)
- IMPACT OF GENETICS AND GENETIC MONITORING ON PHARMACOLOGY STUDIES (1983) (1)
- A Case in Which a Second Gastrointestinal Lesion Was Masked by a Gastrostomy (1966) (1)
- Letter to the editor for “Update of the human and mouse Fanconi anemia genes” (2016) (1)
- Drugs and the MousePharmacology, Pharmacogenetics, and Pharmacogenomics (2007) (1)
- Odorant receptor polymorphisms in patients with non-allergic vasomotor rhinitis☆ (2004) (1)
- Mouse Dioxin-Inducible Ahd4 Gene (1996) (1)
- Expression, Function and Regulation of Mouse Cytochrome P450 Enzymes: Comparison With Human Cytochrome P450 Enzymes (2010) (1)
- Mouse dioxin-inducible Ahd4 gene. Structure of the 5' flanking region and transcriptional regulation. (1997) (1)
- The murine Ah locus: genetic differences in birth defects among individuals in the same uterus. (1980) (1)
- DNA binding of benzo[a]pyrene metabolites. Effects of substrate and microsomal protein concentration in vitro, dietary contaminants, and tissue differences. (1980) (1)
- Thoughts and Speculation about the Role of Arsenic in Toxicity and Cancer IN (1)
- Perceptions of genetic research in three rural Appalachian Ohio communities (2012) (0)
- Subject Index, Vol. 18, 1979 (1979) (0)
- Behavioral phenotyping of two mouse lines with reduced antioxidant capacity (2012) (0)
- Mouse cytochrome P3450: complete cDNA and amino acid sequence (0)
- Chapter 2 The P450 Gene Superfamily (1990) (0)
- Regulation ofMouseCYPIAJGeneExpression byDioxin: Requirement ofTwocis-Acting Elements during Induction (1989) (0)
- Genetics and functions of the retinoic acid pathway, with special emphasis on the eye (2019) (0)
- Motion: “Omics are of Value in Safety Evaluation” (2006) (0)
- 913 – EVIDENCE FOR DE NOVO SYNTHESIS OF CYTOCHROME P-448 IN THE “AROMATIC HYDROCARBON RESPONSIVE” MOUSE (1977) (0)
- 1076 – GENETIC REGULATION OF ARYL HYDROCARBON HYDROXYLASE INDUCTION BY CHEMICAL CARCINOGENS AND OTHER ENVIRONMENTAL POLLUTANTS (1978) (0)
- The zinc transporter SLC39A8 is a novel negative feedback regulator of the NF-{kappa}B pathway and innate immune activation (2011) (0)
- Update on the human and mouse lipocalin (LCN) gene family, including evidence the mouse Mup cluster is result of an “evolutionary bloom” (2019) (0)
- Ecogenetics: The Study of Gene–Environment Interactions (2001) (0)
- Autoregulation plus negative and positive control of murine Cyp1a-1 gene expression and the [Ah]battery (1992) (0)
- Fatal Epileptic Seizures in Mice Having Compromised Glutathione and Ascorbic Acid Biosynthesis (2023) (0)
- Abstracts (2002) (0)
- Genetic differences in theophylline (THEO) toxicity associated with the Ah locus: Effects of cimetidine in vitro and in vivo (1982) (0)
- The zinc transporter SLC39A8 is a novel negative feedback regulator of the NF-κB pathway and innate immune activation (116.33) (2011) (0)
- Genetic Dissection of Complex Traits : Susceptibility to Environmental Agents IN THIS ISSUE (2000) (0)
- Cytochrome p1-450 induction involves transcriptional control: proof with the use of a cloned dna probe. Abstr. (1981) (0)
- The Environment , Genes , and Asthma (2000) (0)
- A new home for Human Genomics (2012) (0)
- Why are keratins important? (2022) (0)
- SNP‐chips versus CNV patterns: Thinking outside the box (2009) (0)
- Head-and-neck squamous cell carcinoma risk in smokers: no association detected between phenotype and AHR, CYP1A1, CYP1A2, or CYP1B1 genotype (2016) (0)
- Update of the keratin gene family: evolution, tissue-specific expression patterns, and relevance to clinical disorders (2022) (0)
- Cypla2(-/-) null mutant mice develop normally but show deficient drug metabolism (cytochrome P450/embryonic stem cells/arylamine carcinogenesis) (2005) (0)
- CONTENTS (2006) (0)
- Preservation of the negative image of tooth enamel with dental impression material enhances morphometric measurements of gingival overgrowth (2003) (0)
- Personalized medicine: Advantages and shortcomings of genomics versus metabonomics (2008) (0)
- Association of the ah locus in the mouse with induction of four microsomal enzyme activities by aromatic hydrocarbon. Abstr (1973) (0)
- Differential neurobehavioral responses in PCB-treated mice having different Ahr and Cyp1a2 alleles (2009) (0)
- Why are keratins important? (2022) (0)
- Inducible aryl hydrocarbon hydroxylase and 7, 12-dimethylbenz(a)- anthracene-produced skin tumorigenesis in the mouse. Abstr. (1972) (0)
- Analysis of Constitutive and TCDD-Inducible Expression of Genes in the [Ah] Battery (1991) (0)
- Assignment of dioxin-inducible cytochrome P-450 gene family to Chinese hamster chromosome 4 (1985) (0)
- Letter to the editor for “Update of the human and mouse Fanconi anemia genes” (2016) (0)
- Mammalian GenesCoordinately Regulated byGrowthArrest Signals andDNA-Damaging Agents (1989) (0)
- Differences in Patient Response to Psychotropic Drugs (1999) (0)
- The metabolism of dibenz(a,h)anthracene (dba) by mouse hepatic microcomses and its relationship to dba-induced tumor formation. Abstr. (1982) (0)
- Erratum to: Perceptions of genetic research in three rural Appalachian Ohio communities (2012) (0)
- 823 – THE Ah LOCUS: REGULATORY AND TEMPORAL GENES AFFECTING DRUG TOXICITY AND TERATOGENESIS (1978) (0)
- In utero gene expression in the Slc39a8(neo/neo) knockdown mouse (2018) (0)
- Contents, Vol. 18, 1979 (1979) (0)
- 733 – THE BINDING OF BENZO (A) PYRENE TO DNA CATALYZED BY LUNG MICROSOMES IN VITRO AND IN ISOLATED PERFUSED LUNG (1978) (0)
- Genetic differences in carcinogenic index of benzo[a] pyrene in vivo and binding of its metabolites to dna in vitro. Abstr. (1976) (0)
- Effect of vitamin C deficiency during postnatal development on adult behavior: functional phenotype of Gulo(–/–) knockout mice (2012) (0)
- ベンゾ[a]ピレンの代謝活性化におけるCYP1ファミリーの役割 (2005) (0)
- Pyrolysis products from amino acids and protein : Highest mutagenicity requires cytochrome P 1450 ( environmental mutagenesis / chemical carcinogenesis / cigarette smoking / cytochrome P 450-mediated monooxygenase / metabolic activation ) (0)
- An electron spin resonance study of normal and neoplastic biological material (1964) (0)
- Screening of 16 common therapeutic drugs. Possible association with the Ah locus. (1983) (0)
- A single-gene difference associated with theophylline toxicity in mice (1979) (0)
- Cytosolic receptor for ah locus. Evidence for regulatory gene dysfunction in nonresponsive cell cultures containing the receptor. Abstr. (1977) (0)
- List of Contributors (2019) (0)
- 373 CONTENT AND ORGANIZATION OF SPERMATOZOAN DNA (1981) (0)
- A Tribute to Elliot S. Vesell (1933–2018) (2018) (0)
- Transcriptional start site in the mouse Cyp1a1 (cytochrome P1450) gene. (1989) (0)
- 14 – PRIMARY LIVER, HEPATOMA, AND LYMPHOCYTE CULTURES USED AS MODELS FOR STUDYING GENETIC REGULATION OF DRUG METABOLISM (1977) (0)
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