Daniela M. Ferreira
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Brazilian immunologist and vaccinologist
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Daniela M. Ferreira's Degrees
- Bachelors Biology Federal University of Rio de Janeiro
- Masters Immunology University of São Paulo
- PhD Vaccinology University of Brasília
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Why Is Daniela M. Ferreira Influential?
(Suggest an Edit or Addition)According to Wikipedia, Daniela M. Ferreira is a Brazilian British immunologist. She is a specialist in bacterial infection, respiratory co-infection, mucosal immunology and vaccine responses. She is currently Professor of Respiratory Infection and Vaccinology at the Oxford Vaccine Group in the Department of Paediatrics at the University of Oxford and the Director of the Liverpool Vaccine Group at the Liverpool School of Tropical Medicine. She leads a team of scientists studying protective immune responses against pneumococcus and other respiratory pathogens such as SARS-CoV2. Her team has established a novel method of inducing pneumococcal carriage in human volunteers. They use this model to:Discover how people with risk factors make responses to respiratory bacteria and virus and how this is different from healthy peoplePre-select vaccine candidates and test new vaccines more rapidlyDiscover how the host alters the biology of the bacteria while it is being carriedHer team has played a substantial role in the UK covid-19 pandemic response as a trial site for several COVID-19 vaccine studies including the Oxford / Astrazeneca vaccine.
Daniela M. Ferreira's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK (2020) (3297)
- Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials (2021) (812)
- Streptococcus pneumoniae: transmission, colonization and invasion (2018) (463)
- Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial (2021) (404)
- Pneumolysin Activates the NLRP3 Inflammasome and Promotes Proinflammatory Cytokines Independently of TLR4 (2010) (346)
- Safety and immunogenicity of heterologous versus homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine (Com-COV): a single-blind, randomised, non-inferiority trial (2021) (275)
- Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials (COV001 and COV002) (2021) (150)
- Controlled human infection and rechallenge with Streptococcus pneumoniae reveals the protective efficacy of carriage in healthy adults. (2013) (149)
- Characterization of Protective Mucosal and Systemic Immune Responses Elicited by Pneumococcal Surface Protein PspA and PspC Nasal Vaccines against a Respiratory Pneumococcal Challenge in Mice (2009) (112)
- Immunogenicity, safety, and reactogenicity of heterologous COVID-19 primary vaccination incorporating mRNA, viral-vector, and protein-adjuvant vaccines in the UK (Com-COV2): a single-blind, randomised, phase 2, non-inferiority trial (2021) (108)
- Inflammation induced by influenza virus impairs human innate immune control of pneumococcus (2018) (104)
- T Regulatory Cells Control Susceptibility to Invasive Pneumococcal Pneumonia in Mice (2012) (103)
- The immunising effect of pneumococcal nasopharyngeal colonisation; protection against future colonisation and fatal invasive disease. (2010) (95)
- Experimental infection of human volunteers. (2018) (89)
- Immunization of Mice with Single PspA Fragments Induces Antibodies Capable of Mediating Complement Deposition on Different Pneumococcal Strains and Cross-Protection (2010) (87)
- Experimental Human Pneumococcal Carriage Augments IL-17A-dependent T-cell Defence of the Lung (2013) (82)
- Human alveolar macrophages predominately express combined classical M1 and M2 surface markers in steady state (2018) (76)
- Experimental Human Pneumococcal Carriage (2013) (75)
- Fusion Proteins Containing Family 1 and Family 2 PspA Fragments Elicit Protection against Streptococcus pneumoniae That Correlates with Antibody-Mediated Enhancement of Complement Deposition (2007) (73)
- Efficacy of ChAdOx1 nCoV-19 (AZD1222) Vaccine Against SARS-CoV-2 VOC 202012/01 (B.1.1.7) (2021) (72)
- Human Nasal Challenge with Streptococcus pneumoniae Is Immunising in the Absence of Carriage (2012) (71)
- The adult nasopharyngeal microbiome as a determinant of pneumococcal acquisition (2014) (69)
- First human challenge testing of a pneumococcal vaccine. Double-blind randomized controlled trial. (2015) (65)
- The immunological mechanisms that control pneumococcal carriage (2017) (60)
- Recognition of pneumococcal isolates by antisera raised against PspA fragments from different clades. (2008) (59)
- Nasal immunization of mice with Lactobacillus casei expressing the Pneumococcal Surface Protein A: induction of antibodies, complement deposition and partial protection against Streptococcus pneumoniae challenge. (2008) (57)
- Pulmonary dry powder vaccine of pneumococcal antigen loaded nanoparticles. (2015) (54)
- Optimized Immune Response Elicited by a DNA Vaccine Expressing Pneumococcal Surface Protein A Is Characterized by a Balanced Immunoglobulin G1 (IgG1)/IgG2a Ratio and Proinflammatory Cytokine Production (2008) (53)
- A framework for Controlled Human Infection Model (CHIM) studies in Malawi: Report of a Wellcome Trust workshop on CHIM in Low Income Countries held in Blantyre, Malawi (2017) (51)
- Interaction between the nasal microbiota and S. pneumoniae in the context of live-attenuated influenza vaccine (2019) (47)
- Novel Analysis of Immune Cells from Nasal Microbiopsy Demonstrates Reliable, Reproducible Data for Immune Populations, and Superior Cytokine Detection Compared to Nasal Wash (2017) (47)
- Saliva Alternative to Upper Respiratory Swabs for SARS-CoV-2 Diagnosis (2020) (46)
- Density and duration of experimental human pneumococcal carriage (2014) (45)
- Analysis of Serum Cross-Reactivity and Cross-Protection Elicited by Immunization with DNA Vaccines against Streptococcus pneumoniae Expressing PspA Fragments from Different Clades (2002) (45)
- Combination of Pneumococcal Surface Protein A (PspA) with Whole Cell Pertussis Vaccine Increases Protection Against Pneumococcal Challenge in Mice (2010) (45)
- Polysaccharide-Specific Memory B Cells Predict Protection against Experimental Human Pneumococcal Carriage. (2016) (44)
- Nasal immunization of mice with Lactobacillus casei expressing the pneumococcal surface protein C primes the immune system and decreases pneumococcal nasopharyngeal colonization in mice. (2011) (41)
- Mucosal immunization with PspA (Pneumococcal surface protein A)-adsorbed nanoparticles targeting the lungs for protection against pneumococcal infection (2018) (40)
- Protection against nasal colonization with Streptococcus pneumoniae by parenteral immunization with a DNA vaccine encoding PspA (Pneumococcal surface protein A). (2010) (39)
- Neuraminidase A-Exposed Galactose Promotes Streptococcus pneumoniae Biofilm Formation during Colonization (2016) (39)
- Modulation of nasopharyngeal innate defenses by viral coinfection predisposes individuals to experimental pneumococcal carriage (2015) (37)
- Microinvasion by Streptococcus pneumoniae induces epithelial innate immunity during colonisation at the human mucosal surface (2019) (35)
- Experimental human pneumococcal carriage models for vaccine research. (2011) (34)
- (2021). Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK. The Lancet, 397(10269), 99-111. (2020) (29)
- Pneumococcal Capsular Polysaccharide Immunity in the Elderly (2017) (28)
- Detection of high levels of anti-α-galactosyl antibodies in sera of patients with Old World cutaneous leishmaniasis: a possible tool for diagnosis and biomarker for cure in an elimination setting (2014) (28)
- Characterization of the antibody response elicited by immunization with pneumococcal surface protein A (PspA) as recombinant protein or DNA vaccine and analysis of protection against an intranasal lethal challenge with Streptococcus pneumoniae. (2012) (26)
- Saliva offers a sensitive, specific and non-invasive alternative to upper respiratory swabs for SARS-CoV-2 diagnosis. (2020) (25)
- Pneumococcal Colonization in Healthy Adult Research Participants in the Conjugate Vaccine Era, United Kingdom, 2010–2017 (2019) (24)
- Two Randomized Trials of the Effect of Live Attenuated Influenza Vaccine on Pneumococcal Colonization (2019) (23)
- Innate and adaptive nasal mucosal immune responses following experimental human pneumococcal colonization (2019) (23)
- Upper respiratory tract colonization with Streptococcus pneumoniae in adults (2020) (23)
- Single use and conventional bronchoscopes for Broncho alveolar lavage (BAL) in research: a comparative study (NCT 02515591) (2017) (22)
- Mapping of Epitopes Recognized by Antibodies Induced by Immunization of Mice with PspA and PspC (2014) (21)
- Cross-Reactivity of Antipneumococcal Surface Protein C (PspC) Antibodies with Different Strains and Evaluation of Inhibition of Human Complement Factor H and Secretory IgA Binding via PspC (2012) (21)
- Safety and Immunogenicity Report from the Com-COV Study – a Single-Blind Randomised Non-Inferiority Trial Comparing Heterologous And Homologous Prime-Boost Schedules with An Adenoviral Vectored and mRNA COVID-19 Vaccine (2021) (21)
- DNA vaccines expressing pneumococcal surface protein A (PspA) elicit protection levels comparable to recombinant protein. (2006) (20)
- Comparison of the pulmonary response against lethal and non-lethal intranasal challenges with two different pneumococcal strains. (2009) (20)
- Nasal Pneumococcal Density is Associated with Microaspiration and Heightened Human Alveolar Macrophage Responsiveness to Bacterial Pathogens. (2020) (20)
- Oral Typhoid Vaccination With Live-Attenuated Salmonella Typhi Strain Ty21a Generates Ty21a-Responsive and Heterologous Influenza Virus–Responsive CD4+ and CD8+ T Cells at the Human Intestinal Mucosa (2016) (19)
- Augmented Passive Immunotherapy with P4 Peptide Improves Phagocyte Activity in Severe Sepsis (2016) (17)
- Controlled Inflammatory Responses in the Lungs Are Associated with Protection Elicited by a Pneumococcal Surface Protein A-Based Vaccine against a Lethal Respiratory Challenge with Streptococcus pneumoniae in Mice (2012) (17)
- Antibodies Reactive to Commensal Streptococcus mitis Show Cross-Reactivity With Virulent Streptococcus pneumoniae Serotypes (2018) (15)
- State-of-the-art in the pneumococcal field: Proceedings of the 11th International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD-11) (2020) (15)
- Effect of priming interval on reactogenicity, peak immunological response, and waning after homologous and heterologous COVID-19 vaccine schedules: exploratory analyses of Com-COV, a randomised control trial (2022) (15)
- Protective effect of PCV vaccine against experimental pneumococcal challenge in adults is primarily mediated by controlling colonisation density (2019) (14)
- Upper airways colonisation of Streptococcus pneumoniae in adults aged 60 years and older: A systematic review of prevalence and individual participant data meta-analysis of risk factors (2020) (14)
- Experimental human pneumococcal colonisation in older adults is feasible and safe, not immunogenic (2020) (14)
- Pneumococcal colonisation is an asymptomatic event in healthy adults using an experimental human colonisation model (2019) (12)
- Increased IgG but normal IgA anti-pneumococcal protein antibodies in lung of HIV-infected adults☆ (2013) (12)
- Streptococcus pneumoniae colonization associates with impaired adaptive immune responses against SARS-CoV-2 (2022) (12)
- Nonspecific effects of oral vaccination with live-attenuated Salmonella Typhi strain Ty21a (2019) (11)
- Pneumococcal colonization impairs mucosal immune responses to live attenuated influenza vaccine (2021) (11)
- Human leukocyte antigen alleles associate with COVID-19 vaccine immunogenicity and risk of breakthrough infection (2022) (11)
- Intrapulmonary Pharmacokinetics of Cefepime and Enmetazobactam in Healthy Volunteers: Towards New Treatments for Nosocomial Pneumonia (2020) (10)
- DNA vaccines based on genetically detoxified derivatives of pneumolysin fail to protect mice against challenge with Streptococcus pneumoniae. (2006) (10)
- Preclinical Development of Virulence Attenuated Streptococcus pneumoniae Strains Able to Enhance Protective Immunity Against Pneumococcal Infection. (2020) (10)
- The whole blood phagocytosis assay: a clinically relevant test of neutrophil function and dysfunction in community-acquired pneumonia (2020) (9)
- Hands are vehicles for transmission of Streptococcus pneumoniae in novel controlled human infection study (2018) (9)
- Effect of Live Attenuated Influenza Vaccine on Pneumococcal Carriage (2018) (8)
- Experimental Human Challenge Defines Distinct Pneumococcal Kinetic Profiles and Mucosal Responses between Colonized and Non-Colonized Adults (2021) (8)
- Experimental Human Challenge Reveals Distinct Mechanisms of Acquisition or Protection Against Pneumococcal Colonization (2018) (7)
- Twelve lateral flow immunoassays (LFAs) to detect SARS-CoV-2 antibodies (2021) (6)
- Pneumococcal colonization impairs nasal and lung mucosal immune responses to Live Attenuated Influenza Vaccination in adults (2020) (6)
- Pneumococcal Colonization Rates in Patients Admitted to a United Kingdom Hospital with Lower Respiratory Tract Infection: a Prospective Case-Control Study (2016) (6)
- Evaluation of polymer choice on immunogenicity of chitosan coated PLGA NPs with surface-adsorbed pneumococcal protein antigen PspA4Pro (2021) (6)
- Exploring metal availability in the natural niche of Streptococcus pneumoniae to discover potential vaccine antigens (2020) (6)
- Symptoms associated with influenza vaccination and experimental human pneumococcal colonisation of the nasopharynx (2020) (6)
- Nasopharyngeal colonisation with Streptococcus pneumoniae in malnourished children: a systematic review and meta-analysis of prevalence (2019) (6)
- Airway-resident T cells from unexposed individuals cross-recognize SARS-CoV-2 (2022) (6)
- Dynamic changes in innate immune and T cell function and composition at the nasal mucosa across the human lifespan (2019) (5)
- Association between household air pollution and nasopharyngeal pneumococcal carriage in Malawian infants (MSCAPE): a nested, prospective, observational study (2022) (5)
- A feasibility study of controlled human infection with Streptococcus pneumoniae in Malawi (2021) (5)
- Elicitation of mucosal immunity by proteins of Streptococcus pneumoniae. (2011) (5)
- Microbiota and compartment matter in the COVID-19 response (2021) (5)
- Insights Into the Effects of Mucosal Epithelial and Innate Immune Dysfunction in Older People on Host Interactions With Streptococcus pneumoniae (2021) (4)
- Streptococcus pneumoniae: transmission, colonization and invasion (2018) (4)
- Antibiotic Resistance Is Associated with Integrative and Conjugative Elements and Genomic Islands in Naturally Circulating Streptococcus pneumoniae Isolates from Adults in Liverpool, UK (2020) (4)
- Human Infection Challenge with Serotype 3 Pneumococcus. (2022) (4)
- Epithelial control of colonisation by Streptococcus pneumoniae at the human mucosal surface (2018) (4)
- When Do Coughs and Sneezes Cause Diseases? (2016) (3)
- Mechanisms Causing the Inflammatory Response to Streptococcus pneumoniae (2015) (3)
- Minimally-invasive nasal sampling in children offers accurate pneumococcal colonization detection (2019) (2)
- Streptococcus pneumoniae colonisation associates with impaired adaptive immune responses against SARS-CoV-2 (2021) (2)
- Anti-protein immunoglobulin M responses to pneumococcus are not associated with aging (2018) (2)
- Alveolar T-helper 17 responses to streptococcus pneumoniae are preserved in ART-untreated and treated HIV-infected Malawian adults (2017) (2)
- Mechanisms and kinetics of bacterial clearance after experimental colonisation in adults with asthma (2020) (1)
- The influence of pneumococcal conjugate vaccine-13 on nasal colonisation in a controlled human infection model of pneumococcal carriage in Malawi: a double-blinded randomised controlled trial protocol (2021) (1)
- Obesity, leptin and host defence of Streptococcus pneumoniae: the case for more human research (2022) (1)
- Longevity of duodenal and peripheral T-cell and humoral responses to live-attenuated Salmonella Typhi strain Ty21a (2018) (1)
- Minimally Invasive Nasal Sampling in Children Offers Accurate Pneumococcal Colonization Detection (2019) (1)
- Serum levels of anti-PspA and anti-PspC IgG decrease with age and do not correlate with susceptibility to experimental human pneumococcal colonization (2021) (1)
- Inflammation induced by influenza virus impairs innate control of human pneumococcal carriage (2018) (1)
- Detection of SARS-CoV-2 infection by saliva and nasopharyngeal sampling in frontline healthcare workers: An observational cohort study (2021) (1)
- The influence of pneumococcal conjugate vaccine-13 on nasal colonisation in a controlled human infection model of pneumococcal carriage in Malawi: a double-blinded randomised controlled trial protocol. (2021) (1)
- Innate and adaptive nasal mucosal immune responses following experimental human pneumococcal colonization (2022) (1)
- The nose is the best niche for detection of experimental pneumococcal colonisation in adults of all ages, using nasal wash (2021) (1)
- PCV13 induced IgG responses in serum associate with serotype-specific IgG in the lung. (2021) (1)
- The adult nasopharyngeal microbiome as a determinant of pneumococcal acquisition (2014) (1)
- Targeted Transcriptomic Screen of Pneumococcal Genes Expressed during Murine and Human Infection (2022) (1)
- PWE-130 The human gut mucosal cognate cellular response to live oral typhoid vaccination (2012) (0)
- Intracellular survival of Streptococcus pneumoniae in human alveolar macrophages is augmented with HIV infection (2022) (0)
- Combinatorial multimer staining and spectral flow cytometry facilitate quantification and characterization of polysaccharide-specific B cell immunity (2023) (0)
- Persistence of immune response in heterologous COVID vaccination schedules in the Com-COV2 study – A single-blind, randomised trial incorporating mRNA, viral-vector and protein-adjuvant vaccines (2023) (0)
- Long-term respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination (2023) (0)
- Practical considerations for a TB controlled human infection model (TB-CHIM); the case for TB-CHIM in Africa, a systematic review of the literature and report of 2 workshop discussions in UK and Malawi (2023) (0)
- Pneumococcal Re-Vaccination in Patients Over 65 Years Old with Chronic Respiratory Disease: Clearer Guidance and More Evidence Required (2019) (0)
- Household Air Pollution (HAP) is Associated With Increased Pneumococcal Carriage in Malawian Infants – Malawi Streptococcus pneumoniae Carriage and Air Pollution Exposure (MSCAPE) Study (2021) (0)
- Variability of PspC (Pneumococcal surface protein C) in strains isolated in the University Hospital of the University of São Paulo (Brazil) (2010) (0)
- The nose is the best niche for detection of pneumococcal colonisation following experimental challenge in adults of all ages (2021) (0)
- Isolate differences in colonization efficiency during experimental human pneumococcal challenge (2020) (0)
- Inflammation induced by influenza virus impairs human innate immune control of pneumococcus (2018) (0)
- Induction of IFN-γ and IL-17 by Pneumococcal Surface Protein C-Based Vaccines does not Protect Against a Streptococcus pneumoniae Invasive Challenge (2008) (0)
- Microinvasion by Streptococcus pneumoniae induces epithelial innate immunity during colonisation at the human mucosal surface (2019) (0)
- Experimental Human Nasopharyngeal Challenge With Streptococcus Pneumoniae Results In Humoral And Cellular Immunising Responses In The Lung When Carriage Is Established (2011) (0)
- Thirteen-Valent Pneumococcal Conjugate Vaccine–Induced Immunoglobulin G (IgG) Responses in Serum Associated With Serotype-Specific IgG in the Lung (2021) (0)
- Comprehensive review of safety in Experimental Human Pneumococcal Challenge (2023) (0)
- Nonspecific effects of oral vaccination with live-attenuated Typhi strain Ty21a (2019) (0)
- Quality of antibody responses by adults and young children to 13-valent pneumococcal conjugate vaccination and Streptococcus pneumoniae colonisation. (2022) (0)
- Interaction between the nasal microbiota and S. pneumoniae in the context of live-attenuated influenza vaccine (2019) (0)
- TITLE: BIOFILM FORMATION BY CLOSTRIDIUM DIFFICILE STRAIN FROM CEARÁ, BRAZIL (ICC-45) (2019) (0)
- Evaluation of live attenuated Streptococcus pneumoniae vaccine strains on the epithelial response to colonisation using a human challenge model (2020) (0)
- Neuraminidase A exposed galactose promotes Streptococcus pneumoniae biofilm formation 1 during colonization 2 3 RUNNING TITLE : Galactose promotes pneumococcal biofilms in vivo 4 5 (2016) (0)
- Influence of sex, season and environmental air quality on experimental human pneumococcal carriage acquisition: a retrospective cohort analysis (2021) (0)
- Pneumococcal Specific Lung T Cells Produce Interleukin-17 That Can Increase Uptake Of Pneumococci By Human Alveolar Macrophages (2012) (0)
- Epithelial micro-invasion by Streptococcus pneumoniae induces epithelial-derived innate immunity during colonisation at the human mucosal surface (2018) (0)
- Protection against pneumococcal nasopharyngeal colonization in mice immunized with PspC (“Pneumococcal Surface Protein C”)-based vaccines formulated with whole bacteria as carriers or adjuvants (2010) (0)
- longevity of duodenal and peripheral T-cell and humoral responses to live-attenuated Salmonella Typhy strain Ty21a or Longevity of duodenal T-Cell Responses to TY21a (2018) (0)
- Combination of whole cell pertussis vaccine and the pneumococcal surface protein A (PspA) antigen: proposal of a combined vaccine against pertussis and pneumococcal diseases (2010) (0)
- Randomised Controlled Trial of Pneumococcal Conjugate Vaccine Shows Protection Against Experimental Pneumococcal Carriage in First Human Infection Study in Africa (2022) (0)
- Defining mucosal immunity using mass cytometry following experimental human pneumococcal challenge (2019) (0)
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