Daniela Rotin
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Computer Science
Daniela Rotin's Degrees
- PhD Computer Science Stanford University
- Masters Computer Science Stanford University
- Bachelors Computer Science Stanford University
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(Suggest an Edit or Addition)Daniela Rotin's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Acid pH in tumors and its potential for therapeutic exploitation. (1989) (1592)
- Physiological functions of the HECT family of ubiquitin ligases (2009) (961)
- WW domains of Nedd4 bind to the proline‐rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome. (1996) (833)
- Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation. (1989) (737)
- Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination (1997) (696)
- Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor (1994) (480)
- A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1 (1991) (439)
- Ubiquitination and Endocytosis of Plasma Membrane Proteins: Role of Nedd4/Rsp5p Family of Ubiquitin-Protein Ligases (2000) (378)
- Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome. (1999) (366)
- SH3 domains direct cellular localization of signaling molecules (1993) (308)
- SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high‐affinity binding site for SH2 domains of phospholipase C gamma. (1992) (276)
- Autoinhibition of the HECT-Type Ubiquitin Ligase Smurf2 through Its C2 Domain (2007) (270)
- The Grb10/Nedd4 Complex Regulates Ligand-Induced Ubiquitination and Stability of the Insulin-Like Growth Factor I Receptor (2003) (254)
- A Strategy for Modulation of Enzymes in the Ubiquitin System (2013) (240)
- Role of ubiquitylation in cellular membrane transport. (2006) (235)
- Activation of the mitogen-activated protein kinase signaling pathway in neutrophils. Role of oxidants. (1994) (226)
- An SH3 binding region in the epithelial Na+ channel (alpha rENaC) mediates its localization at the apical membrane. (1994) (225)
- Regulation of the epithelial Na+ channel by Nedd4 and ubiquitination. (2000) (220)
- Activation of the Na+/H+ antiporter during cell volume regulation. Evidence for a phosphorylation-independent mechanism. (1992) (213)
- Solution structure of a Nedd4 WW domain–ENaC peptide complex (2001) (209)
- The C2 Domain of the Ubiquitin Protein Ligase Nedd4 Mediates Ca2+-dependent Plasma Membrane Localization* (1997) (201)
- Drosophila Nedd4, a Ubiquitin Ligase, Is Recruited by Commissureless to Control Cell Surface Levels of the Roundabout Receptor (2002) (181)
- Requirement of the Na+/H+ exchanger for tumor growth. (1989) (180)
- The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization (2008) (179)
- Latent Membrane Protein 2A of Epstein-Barr Virus Binds WW Domain E3 Protein-Ubiquitin Ligases That Ubiquitinate B-Cell Tyrosine Kinases (2000) (176)
- Ubiquitination screen using protein microarrays for comprehensive identification of Rsp5 substrates in yeast (2007) (166)
- Apical Membrane Targeting of Nedd4 Is Mediated by an Association of Its C2 Domain with Annexin Xiiib (2000) (157)
- The guanine nucleotide exchange factor CNrasGEF activates Ras in response to cAMP and cGMP (2000) (153)
- Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins. (2005) (150)
- LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation (2015) (146)
- Influence of hypoxia and an acidic environment on the metabolism and viability of cultured cells: potential implications for cell death in tumors. (1986) (143)
- Neuronal defects and posterior pituitary hypoplasia in mice lacking the receptor tyrosine phosphatase PTPσ (1999) (141)
- Trafficking and cell surface stability of ENaC. (2001) (137)
- Electrophysiological Characterization of the Rat Epithelial Na+ Channel (rENaC) Expressed in MDCK Cells (1998) (135)
- Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays (2009) (134)
- Polymorphisms in E-cadherin (CDH1) result in a mis-localised cytoplasmic protein that is associated with Crohn’s disease (2009) (133)
- The PY Motif of ENaC, Mutated in Liddle Syndrome, Regulates Channel Internalization, Sorting and Mobilization from Subapical Pool (2007) (133)
- Trafficking and Cell Surface Stability of the Epithelial Na+ Channel Expressed in Epithelial Madin-Darby Canine Kidney Cells* (2002) (128)
- System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes. (2016) (126)
- Impaired cell volume regulation in Na(+)-H+ exchange-deficient mutants. (1989) (120)
- mGrb10 Interacts with Nedd4* (1999) (115)
- Enhanced Rate of Nerve Regeneration and Directional Errors After Sciatic Nerve Injury in Receptor Protein Tyrosine Phosphatase ς Knock-Out Mice (2002) (110)
- Cytotoxicity of compounds that interfere with the regulation of intracellular pH: a potential new class of anticancer drugs. (1987) (105)
- Regulation of Nedd4-2 self-ubiquitination and stability by a PY motif located within its HECT-domain. (2008) (104)
- Rsp5/Nedd4 is the major ubiquitin ligase that targets cytosolic misfolded proteins upon heat-stress (2014) (102)
- Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination (2006) (101)
- Role of the ubiquitin system in regulating ion transport (2010) (100)
- Correction of the ΔPhe508 Cystic Fibrosis Transmembrane Conductance Regulator Trafficking Defect by the Bioavailable Compound Glafenine (2010) (98)
- Heterodimerization of c-erbB2 with different epidermal growth factor receptor mutants elicits stimulatory or inhibitory responses. (1992) (95)
- Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease (2011) (95)
- The Second Catalytic Domain of Protein Tyrosine Phosphatase δ (PTPδ) Binds to and Inhibits the First Catalytic Domain of PTPς (1998) (93)
- Ubiquitylation-dependent localization of PLK1 in mitosis (2013) (92)
- Affinity and Specificity of Interactions between Nedd4 Isoforms and the Epithelial Na+ Channel* (2003) (90)
- Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth (2014) (86)
- Structural determinants for high-affinity binding in a Nedd4 WW3* domain-Comm PY motif complex. (2006) (82)
- Immunolocalization of the ubiquitin-protein ligase Nedd4 in tissues expressing the epithelial Na+ channel (ENaC). (1997) (81)
- Tyrosine phosphorylation of NEDD4 activates its ubiquitin ligase activity (2014) (78)
- Nedd4‐1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function (2011) (76)
- Direct Binding of the β1 Adrenergic Receptor to the Cyclic AMP-Dependent Guanine Nucleotide Exchange Factor CNrasGEF Leads to Ras Activation (2002) (72)
- Sequential assignment of proline-rich regions in proteins: Application to modular binding domain complexes (2000) (68)
- The Ubiquitin Ligase Nedd4-1 Participates in Denervation-Induced Skeletal Muscle Atrophy in Mice (2012) (64)
- The Ubiquitin Ligase Nedd4-1 Is Required for Heart Development and Is a Suppressor of Thrombospondin-1* (2009) (64)
- Nedd4-2 and the Regulation of Epithelial Sodium Transport (2012) (63)
- Regulation of the epithelial sodium channel (ENaC) by accessory proteins (2000) (63)
- Presence of SH2 domains of phospholipase C gamma 1 enhances substrate phosphorylation by increasing the affinity toward the epidermal growth factor receptor. (1992) (61)
- Drosophila larval foraging behavior. II. Selection in the sibling species,D. melanogaster andD. simulans (1983) (58)
- Inhaled ENaC antisense oligonucleotide ameliorates cystic fibrosis-like lung disease in mice. (2017) (58)
- Nedd4 Regulates Ubiquitination and Stability of the Guanine-Nucleotide Exchange Factor CNrasGEF* (2001) (57)
- Protein tyrosine phosphatase σ‐deficient mice show aberrant cytoarchitecture and structural abnormalities in the central nervous system (2002) (56)
- Protein-Tyrosine Phosphatase Sigma Is Associated with Ulcerative Colitis (2007) (55)
- LAPTM5 Protein Is a Positive Regulator of Proinflammatory Signaling Pathways in Macrophages* (2012) (54)
- N-Cadherin Is an In Vivo Substrate for Protein Tyrosine Phosphatase Sigma (PTPσ) and Participates in PTPσ-Mediated Inhibition of Axon Growth (2006) (54)
- Synthesis and degradation of C16 juvenile hormone (JH III) during the final two stadia of the cockroach, Diploptera punctata. (1982) (52)
- High-content Functional Screen to Identify Proteins that Correct F508del-CFTR Function*S (2009) (51)
- Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking. (2015) (50)
- Overexpression of protein-tyrosine phosphatase PTP sigma is linked to impaired glucose-induced insulin secretion in hereditary diabetic Goto-Kakizaki rats. (2002) (47)
- Role of the UPS in Liddle syndrome (2007) (46)
- ENaC and its regulatory proteins as drug targets for blood pressure control. (2008) (45)
- WW (WWP) domains: from structure to function. (1998) (45)
- A High Throughput Screen to Identify Substrates for the Ubiquitin Ligase Rsp5* (2005) (45)
- Ubiquitylation‐dependent oligomerization regulates activity of Nedd4 ligases (2017) (44)
- Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice (2020) (44)
- WW domains. (1996) (42)
- Regulation of Commissureless by the Ubiquitin Ligase DNedd4 Is Required for Neuromuscular Synaptogenesis in Drosophila melanogaster (2006) (41)
- The second catalytic domain of protein tyrosine phosphatase delta (PTP delta) binds to and inhibits the first catalytic domain of PTP sigma. (1998) (40)
- The Guanine Nucleotide Exchange Factor CNrasGEF Regulates Melanogenesis and Cell Survival in Melanoma Cells* (2006) (37)
- Interactions between the three CIN85 SH3 domains and ubiquitin: implications for CIN85 ubiquitination. (2008) (36)
- Proline-rich Motifs of the Na+/H+Exchanger 2 Isoform (1999) (34)
- Pituitary, pancreatic and gut neuroendocrine defects in protein tyrosine phosphatase-sigma-deficient mice. (2002) (34)
- Protein tyrosine phosphatase sigma-deficient mice show aberrant cytoarchitecture and structural abnormalities in the central nervous system. (2002) (34)
- N-cadherin is an in vivo substrate for protein tyrosine phosphatase sigma (PTPsigma) and participates in PTPsigma-mediated inhibition of axon growth. (2007) (33)
- A Role for the Ubiquitin Ligase Nedd4 in Membrane Sorting of LAPTM4 Proteins (2011) (33)
- Haemolymph juvenile hormone esterase activity during the reproductive cycle of the viviparous cockroach Diploptera punctata (1982) (32)
- The Ion Transporter NKCC1 Links Cell Volume to Cell Mass Regulation by Suppressing mTORC1. (2019) (30)
- Use of Kinase Inhibitors to Correct ΔF508-CFTR Function* (2012) (28)
- Dynamin inhibitors block activation of mTORC1 by amino acids independently of dynamin (2018) (24)
- Protein tyrosine phosphatase σ targets apical junction complex proteins in the intestine and regulates epithelial permeability (2014) (24)
- PDGF-induced glycosaminoglycan synthesis is mediated via phosphatidylinositol 3-kinase. (1998) (23)
- Functional rescue of DeltaF508-CFTR by peptides designed to mimic sorting motifs. (2009) (23)
- SH 2 domains prevent tyrosine dephosphorylation of the EGF receptor : identification of Tyr 992 as the high-affinity binding site for SH 2 domains of phospholipase CT (23)
- RNA Interference Screen to Identify Kinases That Suppress Rescue of ΔF508-CFTR* (2015) (23)
- NMR studies of tandem WW domains of Nedd4 in complex with a PY motif-containing region of the epithelial sodium channel. (1998) (23)
- Neural stem cells from protein tyrosine phosphatase sigma knockout mice generate an altered neuronal phenotype in culture (2006) (22)
- The Grb 10 / Nedd 4 Complex Regulates Ligand-Induced Ubiquitination and Stability of the Insulin-Like Growth Factor I Receptor (2003) (22)
- Intestinal knockout of Nedd4 enhances growth of Apcmin tumors (2016) (21)
- NMR studies of tandem WW domains of Nedd4 in complex with a PY motif-containing region of the epithelial sodium channel (1998) (21)
- Regulation of ion transport by protein–protein interaction domains (1997) (21)
- Mechanisms of interaction between radiation and drugs with potential for improvements in therapy. (1988) (20)
- [All-Russian Consensus on Diagnosis and Treatment of Celiac Disease in Children and Adults]. (2017) (20)
- Function and Regulation of the Epithelial Na+ Channel ENaC. (2021) (19)
- Expression of the tyrosine phosphatase LAR-PTP2 is developmentally regulated in lung epithelia. (1994) (18)
- The Ubiquitin Ligase Nedd4L Regulates the Na/K/2Cl Co-transporter NKCC1/SLC12A2 in the Colon* (2017) (17)
- Regulation of the Epithelial Na+ Channel by Cytosolic ATP* (2003) (16)
- Abstract CT042: Fecal microbiota transplantation (FMT) and re-induction of anti-PD-1 therapy in refractory metastatic melanoma patients - preliminary results from a phase I clinical trial (NCT03353402) (2019) (15)
- Expression of LAR-PTP2 in rat lung is confined to proliferating epithelia lining the airways and air sacs. (1996) (15)
- Detection of the env MMTV-homologous sequences in mammary carcinoma patient intestine lymphoid tissue (2004) (15)
- CFTR stabilizes ENaC at the plasma membrane. (2007) (15)
- Use of proteome arrays to globally identify substrates for E3 ubiquitin ligases. (2011) (10)
- The possible role of juvenile hormone esterase in the regulation of juvenile hormone titre in the female cockroach Diploptera punctata. (1983) (10)
- A Splice Isoform of DNedd4, DNedd4-Long, Negatively Regulates Neuromuscular Synaptogenesis and Viability in Drosophila (2011) (10)
- Transport of LAPTM 5 to lysosomes requires association with the ubiquitin ligase Nedd 4 , but not LAPTM 5 ubiquitination (2006) (10)
- Apical junction complex proteins and ulcerative colitis: a focus on the PTPRS gene (2008) (9)
- [Breast carcinoma metastasis to the optic nerve: case report and review of literature]. (2013) (8)
- [Diabetes mellitus and nonalcoholic fatty liver disease: The verges of contingency]. (2017) (8)
- Channels, Antiports, and the Regulation of Cell Volume in Lymphoid Cells (1991) (8)
- Regulation of lipid droplet turnover by ubiquitin ligases (2010) (8)
- Problems with Co-Funding in Canada (2005) (7)
- [Clinical and morphological characteristics, diagnostic criteria, and outcomes of surgical treatment of TSH-secreting pituitary adenomas]. (2016) (6)
- [Primary and metastatic Ewing sarcoma of the skull base - case reports and comparative analysis]. (2013) (6)
- Inhibition of eEF2K synergizes with glutaminase inhibitors or 4EBP1 depletion to suppress growth of triple-negative breast cancer cells (2021) (5)
- High-Throughput Functional Analysis of CFTR and Other Apically Localized Proteins in iPSC-Derived Human Intestinal Organoids (2021) (5)
- Drosophila Nedd4-long reduces Amphiphysin levels in muscles and leads to impaired T-tubule formation (2016) (4)
- Phosphorylation of the Chaperone-Like HspB5 Rescues Trafficking and Function of F508del-CFTR (2020) (4)
- Regulation of SH3PX1 by dNedd4-long at the Drosophila neuromuscular junction (2018) (4)
- SOLUTION STRUCTURE OF THE RNEDD4 WWIII DOMAIN-RENAL BP2 PEPTIDE COMPLEX (2001) (4)
- The effect of the drug lonidamine on Chinese hamster ovary cells in vitro and on experimental tumors. (1984) (4)
- Apparent normal lung architecture in protein tyrosine phosphatase-ς-deficient mice (2003) (3)
- [Orbitosphenopetroclival meningeomas: clinical and topographic features and results of combined treatment]. (2013) (3)
- [Stereotactic radiotherapy for cerebral metastases using CyberKnife]. (2012) (3)
- [Development of secondary resistance to dopamine agonists in a patient with giant prolactinoma]. (2010) (3)
- [Lung cancer metastases to the brain: clinical and morphological prognostic factors]. (2013) (3)
- High-throughput functional analysis of CFTR and other apically localized channels in iPSC derived intestinal organoids (2021) (3)
- PDGF-induced glycosaminoglycan synthesis is mediated via phosphatidylinositol 3-kinase. (1998) (2)
- Apparent normal lung architecture in protein tyrosine phosphatase-sigma-deficient mice. (2003) (2)
- [Askenazi (Hurtle) cell tumors of the thyroid]. (2005) (2)
- [Seronegative celiac disease: A case report]. (2016) (2)
- [A new non-invasive method for assessing steatosis in chronic liver diseases]. (2016) (2)
- Regulation of the p38-MAPK pathway by hyperosmolarity and by WNK kinases (2022) (1)
- [Biology of the craniopharyngioma]. (2013) (1)
- Regulation of ENaC by interacting proteins and by ubiquitination. (1999) (1)
- [Transformation of trigeminal nerve tumor into malignant peripheral nerve sheath tumor (MPNST)]. (2012) (1)
- MICROSATELLITE INSTABILITY AND GASTRIC CARCINOMA. REVIEW OF THELITERATURE (2019) (1)
- [Formalized macroscopic description and computer analyser of macroscopic image (as illustrated by gastric pathology)]. (2003) (1)
- Development of pulmonary fibrosis in conditional Nedd4-2 deficient mice (2018) (1)
- [Meningioma with extracranial metastases]. (2011) (1)
- [Melanotic schwannoma of C(III) spinal root]. (2010) (1)
- Perspectivesin CancerResearch Acid pH in Tumors and Its Potential for Therapeutic Exploitation 1 (2006) (1)
- [Sentinel lymph nodes in squamous cell cancer of the head and neck]. (2007) (1)
- The Diagnosis of Breast Cancer after Augmentation Mammoplasty (Case Report) (2017) (1)
- Vasculogenic mimicry in melanoma: molecular mechanisms and clinical significance (2019) (1)
- Regulation of the Epithelial Na (cid:1) Channel by Cytosolic ATP* (2003) (0)
- Health care crisis in Gaza (2009) (0)
- Solution Structure of the dNedd4 WW3* Domain- Comm LPSY Peptide Complex (2006) (0)
- [Hormonally inactivated pituitary adenoma: morphological, immunohistochemical and electron-microscopic characteristic]. (2012) (0)
- [Rare thyroid tumors: spindle-cell epithelial tumor and thyroid carcinoma with thymus-like differentiation]. (2007) (0)
- HspB5 in Cystic Fibrosis (2018) (0)
- In vivo regulation of ENaC by the ubiquitin ligase Nedd4L in lung and intestinal epithelia (2013) (0)
- WS01.1 Identification of a human antisense inhibitor against ENaC for the treatment of cystic fibrosis (2017) (0)
- [Combination of pulmonary lymphangioleiomyomatosis (LAM) with angiomyolipoma (AML) of the kidney and multilocular cystic nephroma]. (2004) (0)
- [Anaplastic thyroid carcinoma: a case report]. (2020) (0)
- Chemical Shift Assignments and Coupling Constants for the rat Nedd4 WWIII domain - rat ENaC bP2 Peptide Complex (2001) (0)
- Resource System-Wide Modulation o f HECT E 3 Ligases with Selective Ubiquitin Variant Probes Graphical Abstract Highlights (2016) (0)
- Split chloramphenicol acetyl-transferase assay reveals self-ubiquitylation-dependent regulation of UBE3B. (2021) (0)
- [Primary esophageal melanoma]. (2018) (0)
- Elevated intracellular Na+ and osmolarity stimulate catalytic activity of the ubiquitin ligase Nedd4-2 (2022) (0)
- [Expert system for the diagnosis of thyroid neoplasms]. (2004) (0)
- Expression rate of ALK tyrosine kinase and TAG-72 oncoprotein in primary skin melanoma (2018) (0)
- Neuromuscular Synaptogenesis in Drosophila (2006) (0)
- Technical Note: The Use of RNA-interference as a Tool to Find Proteins Involved in Melanosome Formation or Transport (2009) (0)
- Hierarchy ofBinding Sites forGrb2andShcontheEpidermal GrowthFactor Receptor (1994) (0)
- C O M M E N TA R Y Open Access (2010) (0)
- [A familial form of medullary carcinoma of the thyroid gland]. (2003) (0)
- Cytotoxic effect of hypoxia plus low ph and of agents that interfere with the regulation of intracellular ph (1986) (0)
- Solution Structure of the C2 domain of human Smurf2 (2007) (0)
- Table of Contents (1994) (0)
- Osobennosti lecheniya bol'noy neorgannoy pleomorfnoy liposarkomoy (2002) (0)
- RNA Interference Screen to Identify Kinases That Suppress Rescue of (cid:2) F508-CFTR* □ S (2015) (0)
- A Novel Mouse Model To Study Innate Immunity And Neutrophil Extracellular Traps (NETs) In Cystic Fibrosis (CF) Lung Disease (2012) (0)
- CURRENT POINT OF VIEW ON PROGNOSTIC AND PREDICTIVE ROLES AND PRACTICAL APPLICATION OF HER2 RECEPTOR’S DETECTION. LITERATURE REVIEW (2020) (0)
- Ki-67 and survivin immunostaining for evaluation of cervical precancer lesions (2008) (0)
- Solitary Fibrous Tumor of Common Bile Duct. CaseReport and Literature Review (2020) (0)
- invited review Trafficking and cell surface stability of ENaC (2001) (0)
- [Insullar cancer. Diagnosis and place in the structure of thyroid carcinoma]. (2005) (0)
- [Mesenteric inflammatory veno-occlusive disease is a rare nosological entity: Literature review and the authors' clinical observation]. (2014) (0)
- 5-ALA-induced PPIX fluorescence in intramedullary tumors (2011) (0)
- [Metastatic skull base tumors (biology, clinical presentation and evaluation)]. (2011) (0)
- [Rupture of thoracic aorta aneurysm 6 years after endoprosthetic surgery]. (2002) (0)
- N-Cadherin Is an In Vivo Substrate for Protein Tyrosine Phosphatase Sigma (PTP (cid:2) ) and Participates in PTP (cid:2) -Mediated Inhibition of Axon Growth (cid:1) † (2006) (0)
- -deficient mice Ϛ phosphatase-normal lung architecture in protein tyrosine (2016) (0)
- Key moments of morphological examination of pancreatic tumors considering modern morphological classification (2019) (0)
- CNrasGEF Leads to Ras Activation Guanine Nucleotide Exchange Factor Receptor to the Cyclic AMP-Dependent 1 Adrenergic β Direct Binding of the (2002) (0)
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Daniela Rotin is affiliated with the following schools:
