Dario Alessi

Q: What Schools Are Affiliated With Dario Alessi

Dario Alessi is affiliated with the following schools: University of Oxford, Central South University, University of Dundee, Institute of Science Tokyo, University of Birmingham, University of California, San Francisco

Dario Alessi's AcademicInfluence.com Rankings

Dario Alessi

Biology

#1410

World Rank

#2373

Historical Rank

Biochemistry

#380

World Rank

#453

Historical Rank

biology Degrees

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Biology

Dario Alessi's Degrees

PhD Biochemistry University of Dundee
Bachelors Biochemistry University of Dundee

Why Is Dario Alessi Influential?

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According to Wikipedia, Dario Renato Alessi is a French-born British biochemist, Director of the Medical Research Council Protein Phosphorylation and Ubiquitylation Unit and Professor of Signal Transduction, at the School of Life Sciences, University of Dundee.

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Dario Alessi's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B (1995) (5216)
PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo(*) (1995) (3549)
Mechanism of activation of protein kinase B by insulin and IGF‐1. (1996) (3060)
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα (1997) (2859)
The selectivity of protein kinase inhibitors: a further update. (2007) (2545)
Metformin and reduced risk of cancer in diabetic patients (2005) (2232)
The PI3K-PDK1 connection: more than just a road to PKB. (2000) (1660)
Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade (2003) (1547)
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1 (2004) (1295)
The nuts and bolts of AGC protein kinases (2010) (1246)
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. (1998) (1152)
PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? (2001) (1150)
Role of Translocation in the Activation and Function of Protein Kinase B* (1997) (1094)
Mitogen‐ and stress‐activated protein kinase‐1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB (1998) (1039)
New Users of Metformin Are at Low Risk of Incident Cancer (2009) (1031)
Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. (1999) (946)
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). (2008) (888)
PDK1, the master regulator of AGC kinase signal transduction. (2004) (830)
Mechanism of activation and function of protein kinase B. (1998) (808)
Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase (2001) (786)
LKB1-dependent signaling pathways. (2006) (755)
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65 (2012) (744)
3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase (1997) (735)
Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases (2016) (680)
Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase‐1 and p70 S6 kinase (1996) (650)
Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65 (2014) (630)
Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis (2005) (605)
Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction (2005) (571)
3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro (1998) (569)
Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. (2000) (567)
Identification of the sites in MAP kinase kinase‐1 phosphorylated by p74raf‐1. (1994) (539)
FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P (2004) (533)
Emerging roles of pseudokinases. (2006) (523)
LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity. (2007) (514)
The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells (2000) (495)
Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR) (2009) (476)
The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. (2005) (449)
Identification of Protor as a novel Rictor-binding component of mTOR complex-2. (2007) (447)
PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2 (1999) (446)
Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling Cascades* (1997) (445)
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms (2020) (444)
Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual‐specificity phosphatase. (1996) (429)
Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice. (2008) (404)
Mitogenic Activation, Phosphorylation, and Nuclear Translocation of Protein Kinase Bβ* (1997) (402)
Activation of the tumour suppressor kinase LKB1 by the STE20‐like pseudokinase STRAD (2003) (387)
Characterization of a selective inhibitor of the Parkinson’s disease kinase LRRK2 (2011) (383)
The PIF‐binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB (2001) (381)
MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm (2003) (380)
Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines (1995) (373)
The control of protein phosphatase-1 by targetting subunits. The major myosin phosphatase in avian smooth muscle is a novel form of protein phosphatase-1. (1992) (368)
14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization (2010) (363)
Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells. (2012) (362)
Kinase drug discovery--what's next in the field? (2013) (361)
Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1. (1999) (352)
Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser910/Ser935, disruption of 14-3-3 binding and altered cytoplasmic localization (2010) (351)
Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells. (1998) (343)
Essential role of PDK1 in regulating cell size and development in mice (2002) (337)
Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity. (2000) (337)
Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR. (2004) (332)
LRRK2 activation in idiopathic Parkinson’s disease (2018) (332)
Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation (2009) (329)
Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation. (1996) (323)
The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts. (1993) (321)
Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo. (1999) (320)
Activation of the thiazide-sensitive Na+-Cl– cotransporter by the WNK-regulated kinases SPAK and OSR1 (2008) (317)
The insulin signalling pathway (2002) (317)
Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer. (2013) (306)
Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. (2001) (305)
Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis (2017) (301)
Discovery of potent and selective covalent inhibitors of JNK. (2012) (298)
Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C‐terminal residues of PKA (2000) (292)
Phosphorylation of the Protein Kinase Mutated in Peutz-Jeghers Cancer Syndrome, LKB1/STK11, at Ser431 by p90RSK and cAMP-dependent Protein Kinase, but Not Its Farnesylation at Cys433, Is Essential for LKB1 to Suppress Cell Growth* (2001) (290)
High-Resolution Structure of the Pleckstrin Homology Domain of Protein Kinase B/Akt Bound to Phosphatidylinositol (3,4,5)-Trisphosphate (2002) (285)
Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1. (2006) (282)
Phosphoprotein Analysis Using Antibodies Broadly Reactive against Phosphorylated Motifs* (2002) (275)
The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2. (1998) (273)
LKB1 and AMPK and the cancer-metabolism link - ten years after (2013) (271)
BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo. (2007) (270)
The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway (2008) (270)
Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha. (1998) (261)
Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast (1999) (259)
Screening of DUB activity and specificity by MALDI-TOF mass spectrometry (2014) (259)
PDK1, one of the missing links in insulin signal transduction? 1 (1997) (258)
Protein Lipid Overlay Assay (2002) (257)
Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change. (2003) (254)
Role of the WNK-activated SPAK kinase in regulating blood pressure (2010) (250)
Further evidence that the inhibition of glycogen synthase kinase‐3β by IGF‐1 is mediated by PDK1/PKB‐induced phosphorylation of Ser‐9 and not by dephosphorylation of Tyr‐216 (1997) (249)
Arachidonic acid inhibits myosin light chain phosphatase and sensitizes smooth muscle to calcium. (1992) (245)
Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). (2010) (243)
Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway (2009) (238)
Rab29 activation of the Parkinson's disease‐associated LRRK2 kinase (2017) (237)
MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. (2003) (235)
Activation of the renal Na+:Cl− cotransporter by angiotensin II is a WNK4-dependent process (2012) (231)
Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains. (2008) (231)
The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase‐1β (Rsk‐2) and p70 S6 kinase (1997) (230)
Further evidence that 3‐phosphoinositide‐dependent protein kinase‐1 (PDK1) is required for the stability and phosphorylation of protein kinase C (PKC) isoforms (2000) (221)
Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1. (2006) (218)
The role of PI 3-kinase in insulin action. (1998) (217)
The WNK-SPAK/OSR1 pathway: Master regulator of cation-chloride cotransporters (2014) (213)
Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop (2011) (210)
USP7 small-molecule inhibitors interfere with ubiquitin binding (2017) (203)
Modulation of Insulin-stimulated Degradation of Human Insulin Receptor Substrate-1 by Serine 312 Phosphorylation* (2003) (200)
Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia (2003) (199)
Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase (2014) (198)
Regulation of Akt/PKB Ser473 phosphorylation. (2005) (197)
Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease. (2009) (197)
The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling (2012) (195)
High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site (2002) (190)
In vivo role of the PIF‐binding docking site of PDK1 defined by knock‐in mutation (2003) (189)
A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer (2014) (188)
LKB1, a protein kinase regulating cell proliferation and polarity (2003) (185)
A 3-Phosphoinositide-dependent Protein Kinase-1 (PDK1) Docking Site Is Required for the Phosphorylation of Protein Kinase Cζ (PKCζ) and PKC-related Kinase 2 by PDK1* (2000) (184)
The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction (2013) (182)
Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates (2004) (182)
LRRK2 kinase in Parkinson's disease (2018) (181)
New Insights into mTOR Signaling: mTORC2 and Beyond (2009) (181)
Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney. (2011) (179)
Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase. (2002) (176)
New Roles for the LKB1-NUAK Pathway in Controlling Myosin Phosphatase Complexes and Cell Adhesion (2010) (174)
Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress (2007) (173)
PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition (2016) (172)
The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+–Cl− co-transporters (2014) (170)
Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf. (1995) (169)
Inhibitor-2 functions like a chaperone to fold three expressed isoforms of mammalian protein phosphatase-1 into a conformation with the specificity and regulatory properties of the native enzyme. (1993) (169)
Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation (2015) (168)
PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response. (2008) (163)
Identification of the sucrose non‐fermenting related kinase SNRK, as a novel LKB1 substrate (2005) (163)
Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways (2011) (161)
The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation (2004) (159)
Effect of Contraction on Mitogen-activated Protein Kinase Signal Transduction in Skeletal Muscle (2000) (159)
Analysis of the LKB1-STRAD-MO25 complex (2004) (155)
TSC1–TSC2: a complex tale of PKB-mediated S6K regulation (2002) (154)
Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors (2013) (148)
Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation (2017) (147)
Evidence That 3-Phosphoinositide-dependent Protein Kinase-1 Mediates Phosphorylation of p70 S6 Kinase in Vivoat Thr-412 as well as Thr-252* (1999) (147)
ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor (2009) (143)
Hypomorphic Mutation of PDK1 Suppresses Tumorigenesis in PTEN+/− Mice (2005) (140)
Characterisation of a plant 3‐phosphoinositide‐dependent protein kinase‐1 homologue which contains a pleckstrin homology domain (1999) (140)
GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor. (2012) (136)
Lithium Prevents and Ameliorates Experimental Autoimmune Encephalomyelitis1 (2008) (136)
The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development (2004) (134)
Discovery of PDK1, one of the missing links in insulin signal transduction. Colworth Medal Lecture. (2001) (134)
Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1. (2011) (133)
A pathway for Parkinson’s Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain (2018) (131)
Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors (2016) (130)
Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance (2008) (130)
Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366. (2002) (129)
LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages (2018) (126)
PRR5L degradation promotes MTORC2-mediated PKCδ phosphorylation and cell migration downstream of Gα12 (2012) (125)
Phosphorylation of STIM1 at ERK1/2 target sites modulates store-operated calcium entry (2010) (121)
MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases (2011) (121)
Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity (2014) (121)
Use of Akt Inhibitor and a Drug-resistant Mutant Validates a Critical Role for Protein Kinase B/Akt in the Insulin-dependent Regulation of Glucose and System A Amino Acid Uptake* (2008) (120)
Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils (2017) (118)
Functional Characterization of Human RSK4, a New 90-kDa Ribosomal S6 Kinase, Reveals Constitutive Activation in Most Cell Types* (2005) (115)
Brain Penetrant LRRK2 Inhibitor. (2012) (115)
The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human (2018) (114)
Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M (1994) (113)
Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition. (2003) (113)
Phosphoinositide-regulated kinases and phosphoinositide phosphatases. (2001) (112)
The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation. (2006) (112)
A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research (2021) (111)
SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation (2011) (110)
WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate. (2004) (109)
Small‐Molecule Inhibitors of PDK1 (2008) (109)
14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK (2005) (108)
Characterization of a Protein Kinase B Inhibitor In Vitro and in Insulin-Treated Liver Cells (2007) (107)
Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome. (2002) (106)
Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase (2017) (102)
Lithium inhibits caspase 3 activation and dephosphorylation of PKB and GSK3 induced by K+ deprivation in cerebellar granule cells (2001) (102)
Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo. (2002) (101)
Role of the PDK1–PKB–GSK3 pathway in regulating glycogen synthase and glucose uptake in the heart (2005) (98)
Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations (2011) (95)
Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure. (2005) (94)
Phenformin as prophylaxis and therapy in breast cancer xenografts (2012) (94)
Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability. (2003) (93)
Parkin is activated by PINK 1-dependent phosphorylation of ubiquitin at Ser 65 (2014) (93)
Molecular Basis for the Substrate Specificity of NIMA-related Kinase-6 (NEK6) (2002) (93)
DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides. (1999) (90)
Structural insights into the recognition of substrates and activators by the OSR1 kinase (2007) (83)
Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies (2013) (83)
High-content peptide microarrays for deciphering kinase specificity and biology. (2004) (80)
Interactions of LY333531 and other bisindolyl maleimide inhibitors with PDK1. (2004) (79)
LKB 1 is a master kinase that activates 13 protein kinases of the AMPK subfamily , including the MARK / PAR-1 kinases (2004) (77)
Heart 6-Phosphofructo-2-kinase Activation by Insulin Results from Ser-466 and Ser-483 Phosphorylation and Requires 3-Phosphoinositide-dependent Kinase-1, but Not Protein Kinase B* (1999) (77)
Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity. (2013) (76)
Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo (2002) (76)
Characterization of TAE684 as a potent LRRK2 kinase inhibitor. (2012) (76)
Use of kinase inhibitors to dissect signaling pathways. (2000) (76)
Crystal structure of MO25α in complex with the C terminus of the pseudo kinase STE20-related adaptor (2004) (71)
Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B. (2003) (70)
Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation (2006) (70)
Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease (2020) (69)
Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors. (2012) (68)
Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade (2011) (68)
Phosphatidylinositol 3-Kinase/Akt Signaling Pathway Activates the WNK-OSR1/SPAK-NCC Phosphorylation Cascade in Hyperinsulinemic db/db Mice (2012) (68)
Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity. (2001) (64)
The WNK 1 and WNK 4 protein kinases that are mutated in Gordon ’ s hypertension syndrome phosphorylate and activate SPAK and OSR 1 protein kinases (2005) (64)
Discovery of PDK1, one of the missing links in insulin signal transduction. Colworth Medal Lecture (2001) (63)
PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins (2019) (63)
Phosphorylation of Synaptic Vesicle Protein 2A at Thr84 by Casein Kinase 1 Family Kinases Controls the Specific Retrieval of Synaptotagmin-1 (2015) (61)
Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases (2013) (61)
Membrane association but not identity is required for LRRK2 activation and phosphorylation of Rab GTPases (2019) (61)
Integrated single-cell genetic and transcriptional analysis suggests novel drivers of chronic lymphocytic leukemia (2017) (60)
Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation (2014) (59)
Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1. (2003) (58)
Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader (2019) (57)
Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity (2013) (57)
Nerve growth factor promotes activation of the alpha, beta and gamma isoforms of protein kinase B in PC12 pheochromocytoma cells. (1998) (55)
A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo (2011) (55)
Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader (2019) (54)
Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P2 in regulating insulin sensitivity defined by knock-in analysis. (2011) (54)
Effect of heterozygous deletion of WNK1 on the WNK-OSR1/SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels (2012) (53)
In vivo role of the phosphate groove of PDK1 defined by knockin mutation (2005) (53)
Effects of exercise on mitogen- and stress-activated kinase signal transduction in human skeletal muscle. (2000) (52)
Peroxovanadate induces tyrosine phosphorylation of phosphoinositide-dependent protein kinase-1 potential involvement of src kinase. (2000) (52)
Photoactivatable Prodrugs of Antimelanoma Agent Vemurafenib. (2015) (51)
Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity (2001) (51)
BI-D 1870 is a specific inhibitor of the p 90 RSK ( ribosomal S 6 kinase ) isoforms in vitro and in vivo (2006) (50)
Functional analysis of LKB1/STK11 mutants and two aberrant isoforms found in Peutz‐Jeghers Syndrome patients (2003) (50)
TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development. (2011) (49)
SORLA/SORL1 Functionally Interacts with SPAK To Control Renal Activation of Na+-K+-Cl− Cotransporter 2 (2010) (49)
Effect of PI3K- and mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKB1-deficient mice (2011) (48)
3'phosphoinositide‐dependent kinase‐1 is essential for ischemic preconditioning of the myocardium (2006) (46)
Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation. (2010) (46)
Crystal structure of the WD40 domain dimer of LRRK2 (2019) (44)
The hVps34‐SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth (2016) (44)
USP45 deubiquitylase controls ERCC1–XPF endonuclease-mediated DNA damage responses (2014) (44)
Role of T-loop Phosphorylation in PDK1 Activation, Stability, and Substrate Binding* (2005) (43)
Structure of the OSR1 kinase, a hypertension drug target (2008) (43)
Evaluation of Approaches to Generation of Tissue-specific Knock-in Mice* (2006) (42)
Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2 (2020) (41)
Phosphoinositide 3-kinase-dependent phosphorylation of the dual adaptor for phosphotyrosine and 3-phosphoinositides by the Src family of tyrosine kinase. (2000) (40)
N-terminal Serine Dephosphorylation Is Required for KCC3 Cotransporter Full Activation by Cell Swelling* (2013) (40)
Crystal Structure of the PTPL1/FAP-1 Human Tyrosine Phosphatase Mutated in Colorectal Cancer (2004) (39)
Vomocytosis of live pathogens from macrophages is regulated by the atypical MAP kinase ERK5 (2017) (39)
Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor. (2015) (39)
Interaction of TAPP adapter proteins with phosphatidylinositol (3,4)‐bisphosphate regulates B‐cell activation and autoantibody production (2012) (38)
Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains. (2018) (37)
Functional kinomics establishes a critical node of volume-sensitive cation-Cl− cotransporter regulation in the mammalian brain (2016) (37)
Activation of protein kinase B β and γ isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro : comparison with protein kinase B α (1998) (37)
Uncoupling the Warburg effect from cancer (2010) (36)
Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones (2013) (36)
Proteinuria in mice expressing PKB/SGK-resistant GSK3. (2009) (34)
Reduced intestinal and renal amino acid transport in PDK1 hypomorphic mice (2006) (33)
The hVps34‐SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth (2016) (33)
Partial purification and characterization of a wortmannin-sensitive and insulin-stimulated protein kinase that activates heart 6-phosphofructo-2-kinase. (2000) (32)
R1441G but not G2019S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophils (2021) (32)
Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity (2020) (31)
Critical role of the SPAK protein kinase CCT domain in controlling blood pressure (2015) (31)
Accurate MS-based Rab10 phosphorylation stoichiometry determination as readout for LRRK2 activity in Parkinson’s disease (2019) (29)
Structural Characterization of LRRK2 Inhibitors. (2015) (29)
Characterization of VPS 34-IN 1 , a selective inhibitor of Vps 34 , reveals that the phosphatidylinositol 3-phosphate-binding SGK 3 protein kinase is a downstream target of class III phosphoinositide 3-kinase (2014) (29)
Temporal Differences in the Dependency on Phosphoinositide-Dependent Kinase 1 Distinguish the Development of Invariant Vα14 NKT Cells and Conventional T Cells (2010) (28)
Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3. (2005) (28)
Mechanism of activation of SGK3 by growth factors via the Class 1 and Class 3 PI3Ks (2017) (28)
Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites (2020) (27)
New anti-cancer role for PDK1 inhibitors: preventing resistance to tamoxifen. (2009) (26)
Regulation of Glucose-6-phosphatase Gene Expression by Protein Kinase Bα and the Forkhead Transcription Factor FKHR (2000) (26)
Substrate specificity and inhibitors of LRRK 2 , a protein kinase mutated in Parkinson ’ s disease (2009) (26)
Small-Molecule Inhibitors of LRRK2. (2017) (25)
Structural insights into the activation of MST3 by MO25 (2013) (23)
Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain (2021) (22)
Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation. (2013) (22)
Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms (2020) (22)
Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPK 2 but not AMPK 1 (2006) (21)
PKB/SGK-Resistant GSK-3 Signaling Following Unilateral Ureteral Obstruction (2014) (21)
Regulation of membrane ruffling by polarized STIM1 and ORAI1 in cortactin-rich domains (2017) (20)
Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase (2014) (20)
Synthesis and properties of a conformationally restricted spin-labeled analog of ATP and its interaction with myosin and skeletal muscle. (1992) (20)
Phosphorylation of Parkin at Serine 65 is essential for activation : elaboration of a Miro 1 substrate-based assay of Parkin E 3 ligase activity (2014) (20)
Impact of Type II LRRK2 inhibitors on signaling and mitophagy (2021) (20)
Deﬁciency of LKB1 in heart prevents ischemia-mediated activation of AMPK (cid:1) 2 but not AMPK (cid:1) 1 (2006) (19)
Impaired intestinal NHE3 activity in the PDK1 hypomorphic mouse. (2006) (18)
Bi-functional, Substrate Mimicking RNA Inhibits MSK1-mediated cAMP-response Element-binding Protein Phosphorylation and Reveals Magnesium Ion-dependent Conformational Changes of the Kinase* (2002) (18)
MO 25 is a master regulator of SPAK / OSR 1 and MST 3 / MST 4 / YSK 1 protein kinases (2011) (18)
Development of BromoTag: A “Bump-and-Hole”–PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins (2021) (16)
Structural basis of human LRRK2 membrane recruitment and activation (2022) (16)
Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice (2018) (15)
Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction (2014) (15)
Mutation of the PDK 1 PH Domain Inhibits Protein Kinase B / Akt , Leading to Small Size and Insulin Resistance † (2008) (15)
Impaired intestinal and renal glucose transport in PDK-1 hypomorphic mice. (2006) (14)
How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance (2010) (13)
The role that inactivation of GSK 3 isoforms resulting from Ser 9 / Ser 21 phosphorylation plays in insulin-signalling and Wnt-mediated-catenin stabilisation defined by knockin analysis (2005) (13)
University of Dundee LKB 1 and AMPK and the cancer-metabolism link-ten years after (2013) (12)
Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding (2022) (12)
Mutational analysis of the coding regions of the genes encoding protein kinase B-alpha and -beta, phosphoinositide-dependent protein kinase-1, phosphatase targeting to glycogen, protein phosphatase inhibitor-1, and glycogenin: lessons from a search for genetic variability of the insulin-stimulated g (1999) (12)
Rab29 activation of the Parkinson's disease‐associated LRRK2 kinase (2019) (12)
Accurate MS-based Rab10 Phosphorylation Stoichiometry Determination as Readout for LRRK2 Activity in Parkinson's Disease (2020) (12)
Characterization of GSK 2334470 , a novel and highly specific inhibitor of PDK 1 (2010) (12)
35th Annual meeting of the European Association for the Study of Diabetes. Brussels, Belgium, 28 September-2 October, 1999. Abstracts. (1999) (11)
Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood–Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2 (2022) (11)
Author response: Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases (2016) (11)
ACCELERATED PUBLICATION Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser 65 (2014) (10)
Role of TAPP 1 and TAPP 2 adaptor binding to PtdIns ( 3 , 4 ) P 2 in regulating insulin sensitivity defined by knockin analysis (2011) (9)
A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation (2022) (9)
Structural insights into the recognition of substrates and activators by the OSR 1 kinase (2013) (9)
Discovery of PDKI One of the Missing Links in Insulin (2001) (9)
Crystal structure of LRRK2 WD40 domain dimer (2019) (9)
B‐cell‐intrinsic function of TAPP adaptors in controlling germinal center responses and autoantibody production in mice (2017) (9)
PP1 Phosphatase Complexes: Undruggable No Longer (2018) (8)
Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44 (2019) (8)
correlates with PRAS40 phosphorylation 2 (2010) (8)
Corrigendum The hVps 34-SGK 3 pathway alleviates sustained PI 3 K / Akt inhibition by stimulating mTORC 1 and tumour growth (2016) (8)
University of Dundee PDK 1-SGK 1 signaling sustains AKT-independent mTORC 1 activation and confers resistance to PI 3 K inhibition (2016) (8)
Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson’s disease in midbrain dopaminergic neurons (2022) (6)
Accurate MS-based Rab10 Phosphorylation Stoichiometry Determination as Readout for LRRK2 Activity in Parkinson's Disease. (2020) (6)
Phosphatidylinositol 3-Kinase / Akt Signaling Pathway Activates the WNK-OSR 1 / SPAK-NCC Phosphorylation Cascade in Hyperinsulinemic db / db Mice (6)
Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation. (2020) (6)
How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance (2011) (6)
Structural biology: Security measures of a master regulator (2013) (5)
Role of KLHL3 and dietary K+ in regulating KS-WNK1 expression (2021) (5)
Conformationally restricted spin labelled nucleotides: a model study of the synthesis and properties of the 2′,3′-O-spiro ketal of uridine and 4-oxo-2,2,6,6-tetramethyl-1-piperidyloxy (1991) (5)
Discovery of potent and selective 5-azaindazole inhibitors of leucine-rich repeat kinase 2 (LRRK2) - Part 1. (2019) (5)
Author response: Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis (2017) (5)
A minimal cytoplasmic subdomain of the erythropoietin receptor mediates p70 S6 kinase phosphorylation. (2001) (5)
Deciphering the function of leucine-rich repeat kinase 2 and targeting its dysfunction in disease. (2012) (5)
High resolution crystal structure of the human PDK1 catalytic domain (2003) (4)
LRP10 interacts with SORL1 in the intracellular vesicle trafficking pathway in non-neuronal brain cells and localises to Lewy bodies in Parkinson’s disease and dementia with Lewy bodies (2021) (4)
Rab29 knock-out or transgenic overexpression does not impact basal LRRK2 activity in wildtype and pathogenic mouse and cell line models (2020) (4)
PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain (2022) (4)
Novel role for the LKB1 pathway in controlling monocarboxylate fuel transporters (2008) (4)
LKB1 and AMPK and the cancer-metabolism link - ten years after (2013) (4)
Structural insights into the activation of MST 3 by MO 25 (2013) (3)
Endogenous Rab29 does not impact basal or nigericin and monensin stimulated LRRK2 pathway activity (2020) (3)
A mitochondrial blood-based patient stratification candidate biomarker for Parkinson’s disease (2022) (3)
A meeting of minds: Overcoming roadblocks in the development of therapies for neurodegenerative disorders (2009) (3)
Abstract A04: Characterization of VPS34-IN1, a specific inhibitor of Vps34 reveals that the phosphatidylinositol 3-phosphate binding SGK3 protein kinase is regulated by class III PI-3 kinase (2015) (3)
Regulation of Glucose-6-phosphatase Gene Expression by Protein Kinase B a and the Forkhead Transcription Factor (2000) (3)
Cancer, oncogenes and signal transduction (2004) (2)
Disruption of the with no lysine kinase–STE20-proline alanine-rich kinase pathway reduces the hypertension induced by angiotensin II (2017) (2)
Impaired intestinal NHE 3 activity in the PDK 1 hypomorphic mouse (2006) (2)
Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase (2020) (2)
Structural basis for the specificity of PPM1H phosphatase for Rab GTPases (2021) (2)
Structural basis for Rab8a GTPase recruitment of RILPL2 via LRRK2 phosphorylation of switch 2 (2019) (1)
Explorer Deficiency of PDK 1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia (2017) (1)
Crystal structure of the PEPP1 pleckstrin homology domain in complex with Inositol 1,3,4,5-tetrakisphosphate (2004) (1)
Genome-wide screen reveals Rab12 GTPase as a critical activator of pathogenic LRRK2 kinase (2023) (1)
Author response: A pathway for Parkinson’s Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain (2018) (1)
PDK1, the missing link in insulin signal transduction (2000) (1)
Crystal structure of MO25 alpha (2004) (1)
Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration (2022) (1)
Temporal differences in the dependency on Phosphoinositide Dependent Kinase 1 distinguish the development of iNKT cells and conventional T cells (2011) (1)
PDK1, but not PKB, is required for the activation of the Mtor/P70s6k pathway by leucine in the heart (2008) (1)
Structural Basis for Rab8a GTPase Recruitment of RILPL2 via LRRK2-Mediated Phosphorylation of Switch 2 (2020) (1)
University of Dundee Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK 2 Parkinson ’ s disease kinase (2017) (1)
Crystal structure of the pleckstrin homology (PH) domain of PEPP1 (2004) (1)
Golgi-IP, a novel tool for multimodal analysis of Golgi molecular content (2022) (1)
Suppression of cAMP/dexamethasone induced glucose-6-phosphatase gene transcription by insulin (1999) (0)
WNK1 pathway and its role in regulating hypertension (2011) (0)
DISCOVERY OF A NEW ROLE FOR PINK1: PHOSPHORYLATION OF UBIQUITIN BY PINK1 ACTIVATES PARKIN (2014) (0)
Regulation of membrane ruffling by polarized STIM1 and ORAI1 in cortactin-rich domains (2017) (0)
Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation (2017) (0)
Human MST3 (STK24) in complex with MO25beta (2013) (0)
Preface to IUBMB life special issue on protein phosphorylation dedicated to Eddy Fischer (2023) (0)
Abstract 2107: PDK1 blockade overcomes intrinsic resistance to PI3Kα inhibition (2016) (0)
Title Development of phospho-specific Rab protein antibodies tomonitor in vivo activity of the LRRK 2 Parkinson ' s disease kinase (2017) (0)
Crystal structure of the phosphoinositol (3,4)-bisphosphate binding PH domain of TAPP1 from human. (2002) (0)
Science Signaling Podcast: 30 March 2010 (2010) (0)
Structure of Synaptotagmin-1 with SV2A peptide phosphorylated at Thr84 (2015) (0)
Assay for assessing LRRK2 inhibitors (2010) (0)
1 A Feed-forward Pathway Drives LRRK 2 kinase 1 Membrane Recruitment and Activation 2 3 4 5 (0)
Bone loss in KLHL3 knock-in mice characterized by a pseudohypoaldosteronism type II-like phenotype is mediated by renal PTH resistance (2016) (0)
University of Dundee Interplay between Polo kinase , LKB 1-activated NUAK 1 kinase , PP 1 MYPT 1 phosphatase complex and the SCFTrCP E 3 ubiquitin ligase (2014) (0)
A process for the activation of a kinase (1996) (0)
Crystal structure of the human KLHL3 Kelch domain in complex with a WNK4 peptide (2014) (0)
Crystal structure of MO25 in complex with a C-terminal peptide of STRAD (2004) (0)
University of Dundee Characterization of VPS 34-IN 1 , a selective inhibitor of Vps 34 , reveals that the phosphatidylinositol 3-phosphate-binding SGK 3 protein kinase is a downstream target of class III phosphoinositide 3-kinase (2014) (0)
Structure of human PDK1 kinase domain in complex with LY333531 (2004) (0)
Crystal structure of the human KLHL2 Kelch domain in complex with a WNK4 peptide (2014) (0)
Phosphorylation of S6K1 at Thr389 following resistance exercise does not require the PIF‐pocket of PDK1 (2006) (0)
Conformationally Restricted Spin Labelled Nucleotides: A Model Study of the Synthesis and Properties of the 2′,3′-O-Spiro Ketal of Uridine and 4-Oxo-2,2,6,6-tetramethyl-1-piperidyloxy. (1991) (0)
Structure of human PDK1 kinase domain in complex with staurosporine (2004) (0)
Crystal structure of the PH domain of PKB alpha in complex with a sulfate molecule (2004) (0)
Structure of human PDK1 kinase domain in complex with UCN-01 (2004) (0)
Structural and atropisomeric factors governing the selectivity profile of pyrimido-benzodiazipinones as inhibitors of kinases and bromo- domains (2019) (0)
University of Dundee The hVPS 34-SGK 3 pathway counteracts inhibition of the PI 3 K-Akt to maintain mTORC 1 and tumour growth (2016) (0)
Method for screening compounds that interact with protein kinase rac. (1996) (0)
LRRK2 mutations, regulation and 14–3–3 protein interaction: implications for Parkinson’s disease (2011) (0)
Mechanism and activation and function of protein kinase B (2000) (0)
Interactions of the novel PtdIns(3,4)P2 binding proteins TAPP1 and TAPP2 with PDZ domain containing proteins (2001) (0)
CHAPTER 154 – Role of PDK1 in Activating AGC Protein Kinase (2003) (0)
University of Dundee Interrogating Parkinson ' s disease LRRK 2 kinase pathway activity by assessing Rab 10 phosphorylation in human neutrophils (2017) (0)
SPAK/OSR1 kinases directly phosphorylate the K+‐Cl‐ co‐transporters (1109.7) (2014) (0)
A method for application of an on LKB1 / STRAD / MO25 complex (2004) (0)
LKB1 pathway and its role in cancer (2011) (0)
Signal Transduction Downstrean of PI 3-kinase (2001) (0)
Crystal Structure of the PDK1 Pleckstrin Homology (PH) domain bound to DiC4-phosphatidylinositol (3,4,5)-trisphosphate (2004) (0)
Pleckstrin homology polypeptides and dna encoding such (2001) (0)
Decision letter: Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72 (2019) (0)
Structure of PDK1-S241A mutant kinase domain (2005) (0)
University of Dundee The WNK-regulated SPAK / OSR 1 kinases directly phosphorylate and inhibit the K +-Cl-co-transporters (2014) (0)
84th Annual Meeting DPG (2005) (0)
BI-D 1870 is a specific inhibitor of the p 90 Ribosomal S 6 Kinase ( RSK ) isoforms in vitro and in vivo (2006) (0)
The New p.F1700L LRRK2 Variant Causes Parkinson's Disease by Extensively Increasing Kinase Activity. (2023) (0)
Abstract 27: Integrated analysis of targeted single-cell genetic and transcriptional heterogeneity suggests novel drivers of chronic lymphocytic leukemia (2017) (0)
Cloning and characterisation of novel phosphoinositide effector proteins (2001) (0)
1 USP 7 Small Molecule Inhibitors Interfere with Ubiquitin Binding 1 2 (2017) (0)
Cell Highlight_PV_DA (2018) (0)
University of Dundee LRRK 2 is a negative regulator of phagosome maturation in macrophages (2018) (0)
Structure of STRAD and MO25 (2009) (0)
Ronald R. Tasker Young Investigator Award 165 Promoting Endogenous GABAergic Analgesia via Kinase Modulation of Neuronal Ion Plasticity. (2014) (0)
A possible mechanism by which Protein Kinase B is phosphorylated at Ser473 (1999) (0)
Disruption of the WNK/SPAK pathway attenuates angiotensin II, but enhances aldosterone‐induced hypertension (1136.3) (2014) (0)
University of Dundee The Parkinson's disease VPS35[D620N] mutation enhances LRRK2 mediated Rab protein phosphorylation in mouse and human Mir, (2018) (0)
Role of FBXO7 in hereditary parkinsonism (2014) (0)
Abstract SY23-03: Development and mechanistic characterization of USP7 deubiquitinase inhibitors (2018) (0)
SUBSTRATE RECOGNITION POCKET SECOND PHOSPHOTYROSINE Colorectal Cancer: EVIDENCE FOR A Human Tyrosine Phosphatase Mutated in Crystal Structure of the PTPL1/FAP-1 Protein Structure and Folding: (2014) (0)
Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging (2013) (0)
Crystal Structure of the PDK1 Pleckstrin Homology (PH) domain bound to Inositol (1,3,4,5)-tetrakisphosphate (2004) (0)
University of Dundee Structural and biochemical characterization of the KLHL 3-WNK kinase interaction important in blood pressure regulation (2014) (0)
SORLA/SORL1 Functionally Interacts with SPAK To Control Renal Activation of Na (cid:1) -K (cid:1) -Cl (cid:2) Cotransporter 2 (cid:1) (2010) (0)
Phosphoinositide‐Regulated Kinases and Phosphoinositide Phosphatases (2001) (0)
University of Dundee Mechanism of activation of SGK 3 by growth factors-via the Class 1 and Class 3 PI 3 (2017) (0)
Method of identifying compounds interact with RAC kinase proteins (1996) (0)
Humanized Roco4 bound to Compound 19 (2015) (0)
Method for activating a kinase. (1996) (0)
Crystal structure of the pleckstrin homology domain of PKB alpha (2004) (0)
Glycogen synthase kinase-3 (GSK3): a potential therapeutic target to treat neuroinflammation? (2008) (0)
Function and regulation of the PDK1 kinase (2010) (0)
High resolution crystal structure of the Pleckstrin Homology Domain Of Protein Kinase B/Akt Bound To Ins(1,3,4,5)-Tetrakisphophate (2003) (0)
Crystal Structure of the PDK1 Pleckstrin Homology (PH) domain (2004) (0)
Humanized Roco4 bound to LRRK2-In1 (2015) (0)
Structure of the PDK1 PH domain K465E mutant (2008) (0)
32 Functional analysis of PDK1 signalling pathway using knockout and knockin approaches; evaluation of PDK1 as a cancer target (2004) (0)

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