Dario DiFrancesco

Dario DiFrancesco's AcademicInfluence.com Rankings

Dario DiFrancesco

Biology

#4460

World Rank

#6644

Historical Rank

Physiology

#143

World Rank

#309

Historical Rank

biology Degrees

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Biology

Dario DiFrancesco's Degrees

Doctorate Medicine University of Milan
PhD Physiology University of Milan

Why Is Dario DiFrancesco Influential?

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According to Wikipedia, Dario DiFrancesco is a Professor Emeritus at the University of Milano. In 1979, he and collaborators discovered the so-called "funny" current in cardiac pacemaker cells, a new mechanism involved in the generation of cardiac spontaneous activity and autonomic regulation of heart rate. That initiated a new field of research in the heart and brain, where hyperpolarization-activated, cyclic nucleotide-gated channels, the molecular components of "funny" channels cloned in the late 90's, are today known to play fundamental roles in health and disease. Clinically relevant exploitation of the properties of "funny" channels has developed a channel blocker with specific heart rate-slowing action, ivabradine, marketed for the therapy of coronary artery disease, heart failure and the symptomatic treatment of chronic stable angina.

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Dario DiFrancesco's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Pacemaker mechanisms in cardiac tissue. (1993) (872)
A model of cardiac electrical activity incorporating ionic pumps and concentration changes. (1985) (861)
Direct activation of cardiac pacemaker channels by intracellular cyclic AMP (1991) (815)
How does adrenaline accelerate the heart? (1979) (558)
The Role of the Funny Current in Pacemaker Activity (2010) (524)
Properties of the hyperpolarizing‐activated current (if) in cells isolated from the rabbit sino‐atrial node. (1986) (469)
A new interpretation of the pace‐maker current in calf Purkinje fibres. (1981) (391)
Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel. (2006) (389)
Molecular Architecture of the Human Sinus Node: Insights Into the Function of the Cardiac Pacemaker (2009) (367)
A study of the ionic nature of the pace‐maker current in calf Purkinje fibres. (1981) (347)
Voltage‐clamp investigations of membrane currents underlying pace‐maker activity in rabbit sino‐atrial node. (1980) (346)
Physiology and pharmacology of the cardiac pacemaker ("funny") current. (2005) (336)
Muscarinic modulation of cardiac rate at low acetylcholine concentrations. (1989) (283)
What keeps us ticking: a funny current, a calcium clock, or both? (2009) (276)
Properties of the hyperpolarization-activated current in rat hippocampal CA1 pyramidal cells. (1993) (266)
Current-dependent Block of Rabbit Sino-Atrial Node If Channels by Ivabradine (2002) (266)
Characterization of single pacemaker channels in cardiac sino-atrial node cells (1986) (263)
The contribution of the ‘pacemaker’ current (if) to generation of spontaneous activity in rabbit sino‐atrial node myocytes. (1991) (261)
Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4 (2011) (256)
Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease. (2004) (244)
Action of the hyperpolarization-activated current (Ih) blocker ZD 7288 in hippocampal CA1 neurons (1997) (233)
The cardiac hyperpolarizing-activated current, if. Origins and developments. (1985) (220)
Heart Rate Lowering by Specific and Selective If Current Inhibition with Ivabradine (2012) (218)
From funny current to HCN channels: 20 years of excitation. (2002) (216)
Exercise training reduces resting heart rate via downregulation of the funny channel HCN4 (2014) (212)
Heteromeric HCN1–HCN4 Channels: A Comparison with Native Pacemaker Channels from the Rabbit Sinoatrial Node (2003) (211)
Block and activation of the pace‐maker channel in calf Purkinje fibres: effects of potassium, caesium and rubidium (1982) (190)
Funny channels in the control of cardiac rhythm and mode of action of selective blockers. (2006) (190)
Properties of the current if in the sino‐atrial node of the rabbit compared with those of the current iK, in Purkinje fibres. (1980) (185)
A potassium channel protein encoded by chlorella virus PBCV-1. (2000) (183)
Inhibition of the hyperpolarization‐activated current (if) induced by acetylcholine in rabbit sino‐atrial node myocytes. (1988) (181)
Modulation of single hyperpolarization‐activated channels (i(f)) by cAMP in the rabbit sino‐atrial node. (1994) (178)
Muscarinic control of the hyperpolarization‐activated current (if) in rabbit sino‐atrial node myocytes. (1988) (177)
Reduction of K+ Uptake in Glia Prevents Long-Term Depression Maintenance and Causes Epileptiform Activity (1997) (170)
Integrated Allosteric Model of Voltage Gating of Hcn Channels (2001) (146)
Properties of ivabradine‐induced block of HCN1 and HCN4 pacemaker channels (2006) (144)
Localization of Pacemaker Channels in Lipid Rafts Regulates Channel Kinetics (2004) (136)
Interaction of the Pacemaker Channel HCN1 with Filamin A* (2004) (120)
Human cardiac and bone marrow stromal cells exhibit distinctive properties related to their origin. (2011) (116)
Hyperpolarization-activated Cyclic Nucleotide-gated Channel 1 Is a Molecular Determinant of the Cardiac Pacemaker Current I f * (2001) (113)
Dual allosteric modulation of pacemaker (f) channels by cAMP and voltage in rabbit SA node (1999) (110)
Cardiac mesoangioblasts are committed, self-renewable progenitors, associated with small vessels of juvenile mouse ventricle (2008) (108)
Localization of f-channels to caveolae mediates specific beta2-adrenergic receptor modulation of rate in sinoatrial myocytes. (2007) (101)
The onset and autonomic regulation of cardiac pacemaker activity: relevance of the f current. (1995) (99)
Basal responses of the L‐type Ca2+ and hyperpolarization‐activated currents to autonomic agonists in the rabbit sino‐atrial node. (1996) (97)
HCN-related channelopathies (2010) (96)
Serious workings of the funny current. (2006) (95)
A TTX‐sensitive inward sodium current contributes to spontaneous activity in newborn rabbit sino‐atrial node cells. (1996) (94)
Dysfunctional HCN ion channels in neurological diseases (2015) (94)
An updated computational model of rabbit sinoatrial action potential to investigate the mechanisms of heart rate modulation (2012) (94)
Reciprocal role of the inward currents ib, Na and if in controlling and stabilizing pacemaker frequency of rabbit sino-atrial node cells (1992) (88)
Recessive Loss-of-Function Mutation in the Pacemaker HCN2 Channel Causing Increased Neuronal Excitability in a Patient with Idiopathic Generalized Epilepsy (2011) (85)
Differential control of the hyperpolarization‐activated current (i(f)) by cAMP gating and phosphatase inhibition in rabbit sino‐atrial node myocytes. (1997) (83)
Effects of protein kinase inhibitors on canine Purkinje fibre pacemaker depolarization and the pacemaker current i(f). (1991) (83)
The pacemaker current (I(f)) plays an important role in regulating SA node pacemaker activity. (1995) (82)
Distribution of the pacemaker HCN4 channel mRNA and protein in the rabbit sinoatrial node. (2009) (82)
Modulation of rate by autonomic agonists in SAN cells involves changes in diastolic depolarization and the pacemaker current. (2007) (82)
The funny current: cellular basis for the control of heart rate. (2007) (82)
Characterization of the pace‐maker current kinetics in calf Purkinje fibres. (1984) (80)
The effects of calcium on outward membrane currents in the cardiac Purkinje fibre. (1979) (76)
Kinetic and ionic properties of the human HCN2 pacemaker channel (2000) (76)
Small potassium ion channel proteins encoded by chlorella viruses. (2004) (74)
The human gene coding for HCN2, a pacemaker channel of the heart. (1999) (73)
I(f)-dependent modulation of pacemaker rate mediated by cAMP in the presence of ryanodine in rabbit sino-atrial node cells. (2003) (73)
A gain-of-function mutation in the cardiac pacemaker HCN4 channel increasing cAMP sensitivity is associated with familial Inappropriate Sinus Tachycardia (2017) (73)
The Pacemaker Current: From Basics to the Clinics (2007) (72)
The funny current has a major pacemaking role in the sinus node. (2012) (72)
Cardiac pacemaker oscillation and its modulation by autonomic transmitters. (1979) (72)
The Funny Current (2012) (71)
C Terminus-mediated Control of Voltage and cAMP Gating of Hyperpolarization-activated Cyclic Nucleotide-gated Channels* (2001) (70)
Heart rate reduction via selective 'funny' channel blockers. (2007) (68)
Action of serotonin on the hyperpolarization‐activated cation current (Ih) in rat CA1 hippocampal neurons (1999) (68)
The newborn rabbit sino‐atrial node expresses a neuronal type I‐like Na+ channel. (1997) (68)
HCN1 mutation spectrum: from neonatal epileptic encephalopathy to benign generalized epilepsy and beyond (2018) (67)
Cardiac pacemaker /f current and its inhibition by heart rate-reducing agents (2005) (66)
Properties and modulation of If in newborn versus adult cardiac SA node. (1997) (65)
Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): Standardised Reporting for Model Reproducibility, Interoperability, and Data Sharing (2011) (63)
Activation of f‐channels by cAMP analogues in macropatches from rabbit sino‐atrial node myocytes (1997) (63)
Functional characterisation and subcellular localisation of HCN1 channels in rabbit retinal rod photoreceptors (2002) (62)
Functional comparison of HCN isoforms expressed in ventricular and HEK 293 cells (2002) (59)
The viral potassium channel Kcv: structural and functional features (2003) (57)
Some properties of the UL-FS 49 block of the hyperpolarization-activated current (if) in sino-atrial node myocytes (1994) (57)
Modulation of the hyperpolarization-activated current (I(f)) by adenosine in rabbit sinoatrial myocytes. (1996) (56)
Embryonic Stem Cell–Derived CD166+ Precursors Develop Into Fully Functional Sinoatrial-Like Cells (2013) (56)
Cadmium-induced blockade of the cardiac fast Na channels in calf Purkinje fibres (1985) (55)
Control of Cardiac Rate by “Funny” Channels in Health and Disease (2008) (53)
Measurement and significance of the reversal potential for the pace‐maker current (iK2) in sheep Purkinje fibres. (1979) (52)
Cytoskeletal control of rectification and expression of four substates in cardiac inward rectifier K+ channels (1996) (52)
Identification of the Molecular Site of Ivabradine Binding to HCN4 Channels (2013) (50)
Funny Current and Cardiac Rhythm: Insights from HCN Knockout and Transgenic Mouse Models (2012) (50)
An isoform of the cGMP-gated retinal photoreceptor channel gene expressed in the sinoatrial node (pacemaker) region of rabbit heart. (1993) (48)
Na(+) current contribution to the diastolic depolarization in newborn rabbit SA node cells. (2000) (47)
Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness. (2014) (47)
Funny channel gene mutations associated with arrhythmias (2013) (47)
The short N‐terminus is required for functional expression of the virus‐encoded miniature K+ channel Kcv (2002) (47)
Acetylcholine inhibits activation of the cardiac hyperpolarizing-activated current,if (1987) (47)
A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels (2018) (45)
A caveolin-binding domain in the HCN4 channels mediates functional interaction with caveolin proteins. (2012) (43)
Pacemaker Channels (2004) (43)
Long Distance Interactions within the Potassium Channel Pore Are Revealed by Molecular Diversity of Viral Proteins* (2004) (42)
Effects of dronedarone on Acetylcholine‐activated current in rabbit SAN cells (2000) (41)
Acetylcholine reverses effects of beta-agonists on pacemaker current in canine cardiac Purkinje fibers but has no direct action. A difference between primary and secondary pacemakers. (1990) (41)
In Vitro Epigenetic Reprogramming of Human Cardiac Mesenchymal Stromal Cells into Functionally Competent Cardiovascular Precursors (2012) (40)
Molecular composition and functional properties of f-channels in murine embryonic stem cell-derived pacemaker cells. (2009) (39)
Kinetics and magnitude of the time-dependent potassium current in the rabbit sinoatrial node (1979) (39)
Internal and external K+ help gate the inward rectifier. (1989) (38)
L-type but not T-type calcium current changes during postnatal development in rabbit sinoatrial node. (2001) (38)
Mammalian γ2 AMPK regulates intrinsic heart rate (2017) (38)
Implications of the Re-Interpretation of iK2 for the Modelling of the Electrical Activity of Pacemaker Tissues in the Heart (1982) (36)
HCN4, Sinus Bradycardia and Atrial Fibrillation. (2014) (35)
Human iPSC modelling of a familial form of atrial fibrillation reveals a gain of function of If and ICaL in patient-derived cardiomyocytes (2019) (34)
Action of internal pronase on the f‐channel kinetics in the rabbit SA node (1999) (34)
An LQTS6 MiRP1 Mutation Suppresses Pacemaker Current and is Associated with Sinus Bradycardia (2013) (33)
Human cord blood CD34+ progenitor cells acquire functional cardiac properties through a cell fusion process. (2011) (33)
The contribution of potassium accumulation to outward currents in frog atrium. (1980) (31)
Voltage-Dependence of Virus-encoded Miniature K+ Channel Kcv (2002) (31)
Barium-induced blockade of the inward rectifier in calf Purkinje fibres (1984) (30)
Current understanding of the pathophysiological mechanisms responsible for inappropriate sinus tachycardia: role of the If “funny” current (2016) (29)
A novel de novo HCN1 loss-of-function mutation in genetic generalized epilepsy causing increased neuronal excitability (2018) (29)
A circadian clock in the sinus node mediates day-night rhythms in Hcn4 and heart rate (2020) (27)
Inhibition of the hyperpolarization-activated current (if) of rabbit SA node myocytes by niflumic acid (1996) (27)
Intracellular Ca modulates K-inward rectification in cardiac myocytes (2004) (26)
Cardiac pacemaker: 15 years of "new" interpretation. (1995) (25)
A Brief History of Pacemaking (2020) (25)
Mutation in S6 domain of HCN4 channel in patient with suspected Brugada syndrome modifies channel function (2016) (24)
The pacemaker current in cardiac cells (1995) (24)
HCN ion channels and accessory proteins in epilepsy: genetic analysis of a large cohort of patients and review of the literature (2019) (23)
Gating movements and ion permeation in HCN4 pacemaker channels (2020) (21)
If inhibition: a novel mechanism of action (2003) (21)
Intracellular calcium does not directly modulate cardiac pacemaker (if) channels (1991) (21)
A Loss-of-Function HCN4 Mutation Associated With Familial Benign Myoclonic Epilepsy in Infancy Causes Increased Neuronal Excitability (2018) (21)
Mesoangioblasts from ventricular vessels can differentiate in vitro into cardiac myocytes with sinoatrial-like properties. (2010) (20)
Cell-specific Dynamic Clamp analysis of the role of funny If current in cardiac pacemaking. (2016) (18)
Two distinct pathways of muscarinic current responses in rabbit sino-atrial node myocytes (1998) (17)
beta-modulation of pacemaker rate: novel mechanism or novel mechanics of an old one? (2002) (17)
Preferential myofibroblast differentiation of cardiac mesenchymal progenitor cells in the presence of atrial fibrillation (2017) (16)
The pacemaker current in the sinus node. (1987) (15)
The expression of the rare caveolin-3 variant T78M alters cardiac ion channels function and membrane excitability (2017) (15)
The time course of potassium current following potassium accumulation in frog atrium: analytical solutions using a linear approximation. (1980) (15)
Activation of the hyperpolarization-activated current (if) in sino-atrial node myocytes of the rabbit by vasoactive intestinal peptide (1996) (14)
Cesium prevents maintenance of long-term depression in rat hippocampal CA1 neurons. (1994) (14)
Rebuttal: "The funny current in the context of the coupled clock pacemaker cell system". (2012) (14)
Higher cardiogenic potential of iPSCs derived from cardiac versus skin stromal cells. (2016) (13)
Cesium and the Pacemaker Current (1995) (12)
Mutation in pore domain uncovers cation- and voltage-sensitive recovery from inactivation in KAT1 channel. (2000) (12)
Delayed activation of the cardiac pacemaker current and its dependence on conditioning pre-hyperpolarizations (1983) (11)
Funny channel-based pacemaking. (2010) (11)
Discovery of Herbacetin as a Novel SGK1 Inhibitor to Alleviate Myocardial Hypertrophy (2021) (10)
Single-channel properties of the sinoatrial node Na+ current in the newborn rabbit (2001) (9)
The Cardiac Pacemaker Current if (1992) (9)
Block of the cardiac pacemaker current (If) in the rabbit sino-atrial node and in canine Purkinje fibres by 9-amino-1,2,3,4-tetrahydroacridine (1991) (9)
The Ionic Currents Underlying Pacemaker Activity (1985) (9)
Considerations on the size of currents required for pacemaking (2010) (9)
Generation and control of cardiac pacing the pacemaker current. (1991) (8)
Billman Physiology and pharmacology of the cardiac pacemaker ( b funny Q ) current (2005) (7)
Separation of current induced by potassium accumulation from acetylcholine-induced relaxation current in the rabbit S-A node (1980) (7)
The hyperpolarization-activated (if) current: Autonomic regulation and the control of pacing (1996) (7)
The Hyperpolarization-Activated Current (Ih/Iq) in Rat Hippocampal Neurons (1996) (7)
Expression and characterization of a canine hippocampal inwardly rectifying K+ current in Xenopus oocytes. (1992) (6)
AND IDENTIFIED WITH THE CURRENT IF IN THE SA NODE (1982) (5)
Age-Related Changes in Cardiac Autonomic Modulation and Heart Rate Variability in Mice (2021) (5)
Anacardic acid and thyroid hormone enhance cardiomyocytes production from undifferentiated mouse ES cells along functionally distinct pathways (2016) (5)
Multinucleated giant cells with an osteoclast phenotype derived from caprine peripheral blood mononuclear cells. (2011) (4)
Autonomic modulation of heart rate: pitfalls of nonselective channel blockade. (2003) (4)
Differential effects of ACH on cardiac pacemaker cells (1992) (4)
Poster session 2 (2004) (4)
The ‘funny’ side of sepsis (2014) (4)
Letter regarding article by Michels et al, "Single-channel properties support a potential contribution of hyperpolarization-activated cyclic nucleotide-gated channels and If to cardiac arrhythmias". (2005) (4)
The influence of voltage non-uniformity on the determination of Erev for iK2. (1979) (3)
Dependence of the apparent reversal potential for the pace-maker current iK2 on its degree of activation in cardiac Purkinje fibres [proceedings]. (1978) (3)
CHAPTER 18 – Cardiac Pacemaker Currents (2001) (3)
HCN 4 , Sinus Bradycardia and Atrial Fibrillation (2015) (3)
Activation of the hyperpolarization-activated current (i (1996) (3)
Generation of human induced pluripotent stem cells (EURACi001-A, EURACi002-A, EURACi003-A) from peripheral blood mononuclear cells of three patients carrying mutations in the CAV3 gene. (2018) (3)
Ivabradine block of If is current dependent (2002) (3)
Cardiac Pacemaker (If) Current: Physiological and Pharmacological Properties (2006) (3)
Implications of electrogenic Na/Ca exchange in mammalian heart: Computer model (1983) (2)
Comparing pathways for long-term heart rate modulation by the funny current (2019) (2)
Poster Session 2 (2009) (2)
The “Funny” Pacemaker Current (2009) (2)
Properties of the cardiac pacemaker (if) current. (1984) (2)
HCN Channels and Cardiac Pacemaking (2018) (2)
Chapter 12 – Pacemaker Channels and Normal Automaticity (2004) (2)
Low-potassium inotropy in cardiac muscle [proceedings]. (1978) (2)
Molecular localization of HCN4 in rabbit sinoatrial node (2005) (2)
The effects of manganese and barium on the cardiac pacemaker current, i f , in rabbit sino-atrial node myocytes (1991) (2)
On the time course of extracellular ion concentration changes in frog atrium [proceedings]. (1979) (2)
High Na permeability of L-type Ca channels in isolated rabbit SA node cells (1990) (2)
Leonardo da Vinci and the origin of semen (2014) (1)
How “Funny” is the Cardiac Pacemaking? a Quantitative Analysis Based on Dynamic Clamp Recordings (2014) (1)
Developing Synthetic Peptides to Regulate Native HCN Channels (2019) (1)
MiRP 1 Mutation Suppresses Pacemaker Current and is Associated with Sinus Bradycardia (2013) (1)
Mammalian γ2 AMPK regulates intrinsic heart rate (2017) (1)
CHAPTER 22 – Hyperpolarization-Activated (if) Current in Heart (1994) (1)
The effects of calcium on outward membrane currents in Purkinje fibres from sheep hearts [proceedings]. (1977) (1)
F-channel-dependent modulation of cardiac SAN activity in the presence and absence of ryanodine (2002) (1)
Silvio Weidmann: laying the foundations for unravelling the mechanism of heart rhythm (2023) (1)
Characterization of pluripotent stem cells derived from adult mouse testes (2009) (1)
Abstract 11048: Downregulation of HCN4 and the Pacemaker Current (If) Underlies Exercise Training-Induced Sinus Bradycardia (2013) (1)
Funny channels: relevance to pacemaking and importance as a new drug target (2007) (0)
Identification of residues involved in binding of ivabradine to hHCN4 channels (2007) (0)
Pacemaker properties of autorhythmic cells derived from mouse embryonic stem cells (2008) (0)
HCN3 Channel Expression in Human Leukocytes (2017) (0)
Cardiac-derived mesoangioblasts can differentiate into autorhythmic myocytes (2006) (0)
Chinese natural compound decreases pacemaking of rabbit cardiac sinoatrial cells by targeting second messenger regulation of f-channels (2022) (0)
High cardiac differentiation properties are evident in induced pluripotent stem cells obtained from atrial mesenchymal cells (2015) (0)
The pacemaker funny channel : a tool to control heart rate (2007) (0)
Autonomic rate modulation in san cells involves changes in diastolic depolarization and the i(f) current (2007) (0)
The newborn rabbit sino-atrial node expresses an inward sodium current with novel pharmacological characteristics (1997) (0)
Author response: A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels (2018) (0)
Influence of ouabain on the spontaneous oscillations frequency in cardiac pacemaker (1974) (0)
Erratum to: Intracellular Ca modulates K-inward rectification in cardiac myocytes (1989) (0)
Familial Sinus Bradycardia- Bradicardia sinusale familiare (2006) (0)
Cyclic AMP Regulation of the Pacemaker (I f ) Current in Heart (1992) (0)
P1582Molecular basis of cardiac pacemaker ageing in mouse (2017) (0)
Rate-adapted dynamic-clamp of the funny current in sinoatrial pacemaker cells (2015) (0)
Current If and the control of cardiac pacemaking (1990) (0)
The hyperpolarization-activated F-channel (1990) (0)
Characterization of a TTX-sensitive sodium current in neonatal sino-atrial node (1997) (0)
Effects of intracellular cleavage of rabbit SA node f-channel by aspecific protease (2000) (0)
Structural determinant of the ivabradine-induced block of pacemaker HCN channels. (2023) (0)
Mutation in S6 domain of HCN4 channel in patient with suspected Brugada syndrome modifies channel function (2016) (0)
Effects of SR33589B on the ACh-dependent current (IKACh) in the rabbit sinoatrial node cells (1998) (0)
TTX-sensitive inward sodium current in sinoatrial cells isolated from newborn rabbit (1995) (0)
Assessment of the functional relevance of the pacemaker If current using a cardiac-specific and inducible HCN4 KO mouse model (2011) (0)
and secondary pacemakers cardiac Purkinje fibers but has no direct action. A difference between primary Acetylcholine reverses effects of beta-agonists on pacemaker current in canine (2011) (0)
siRNA-mediated knock-down of the HCN4 gene in cultured rabbit neonatal SAN cells (2005) (0)
Pacemaker Mechanism: Control of Heart Rate in Health and Disease (2008) (0)
Physiology and pharmacology of cardiac pacemakers (“funny”) current (2009) (0)
The If current not the SR calcium release, mediates modulation of cardiac pacemaker rate (2005) (0)
Camp-induced control of cardiac pacemaker current (1992) (0)
University of Birmingham Mammalian 2 AMPK regulates intrinsic heart rate (2017) (0)
Abstract 808: Functional Characterization of a Novel Scn5a Mutation Associated With the Brugada Syndrome (2019) (0)
Results 3 . 1 CStC and BMStC morphology , immunophenotype , and molecular marker expression (2011) (0)
Properties of the Current (if) which Underlies Adrenaline Action in the SA Node. Comparison with ik2 in the Purkinje Fibre (1980) (0)
Exercise training reduces the resting heart rate via downregulation of the funny channel, HCN4, and the funny current, If. (2014) (0)
Short sequence-paper The human gene coding for HCN2, a pacemaker channel of the heart 1 (1999) (0)
A Validated Computational Model of Cardiac Pacemaking: Mechanisms of Physiological and Pharmacological Rate Modulation (2012) (0)
postnatal development in rabbit sinoatrial node L-type but not T-type calcium current changes during (2006) (0)
Discovery and Characterization of a Distinct Cyclic Nucleotide Binding Pocket in HCN Channels (2014) (0)
depolarization in newborn rabbit SA node cells current contribution to the diastolic + Na (2000) (0)
Nonselective Channel Blockade Autonomic Modulation of Heart Rate: Pitfalls of (2006) (0)
Saturday, 17 July 2010 (2010) (0)
Expression of KAT1, a plant inward-rectifying potassium channel, in Xenopus oocytes (1995) (0)
Discovery of Herbacetin as a Novel SGK1 Inhibitor to Alleviate Myocardial Hypertrophy (Adv. Sci. 2/2022) (2022) (0)
Dcm Mutations in Tropomyosin Induce Loss of Thermal Stability When the Mutation is Present in a Single Chain of the Tm Dimer (2014) (0)
HCN4 CNBD in complex with cGMP (2014) (0)
Identification of ESC-derived pacemaker myocytes by EGFP expression specifically driven by the promoter of the HCN4 gene (2009) (0)
Obituary: Susan Noble: 1940 – 2015 (2016) (0)
Funny channel-based arrhythmias (2012) (0)
The natural compound TMYX reduces SAN cells rate by antagonizing the cAMP modulation of f-channels (2021) (0)
Rabbit sinoatrial node Nav1.1: identification of splicing variants (2004) (0)
Abstract 12965: Higher Cardiac Differentiation Properties are Evident in Long Term Cultured Induced Pluripotent Stem Cells Obtained From Atrial Mesenchymal Cells Compared to Skin Mesenchymal Cells (2014) (0)
Epigenetics in Cardiac Health and Disease (2016) (0)
Multifactorial Impact of Channel Beta‐Subunit Gene Mutation on Automaticity (2013) (0)
Kinetic properties and molecular determinants of the newborn SAN Na channel (2001) (0)
Abstracts of Papers at the Fifty-Sixth Annual Meeting of the Society of General Physiologists (2002) (0)
Toward a better understanding of HCN4 inhibition by the heart rate reducing agent ivabradine (2008) (0)
More seafood to control heart rate? (2009) (0)
Circadian control of intrinsic heart rate via a sinus node clock and the pacemaker channel (2019) (0)
A Traditional Chinese Medicine Drug (TMYX) Controls Heart Rate by Modulation of the Pacemaker (F) Channels (2017) (0)
Ventricular remodeling in a murine model of cardiac selective and inducible deletion of HCN4 gene (2012) (0)

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