Darlene Dixon
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American veterinary scientist and toxicologic pathologist
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Darlene Dixonmedical Degrees
Medical
#3512
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#3983
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#519
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Toxicology
#54
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#58
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#10
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Darlene Dixonphilosophy Degrees
Philosophy
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#16753
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#2340
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#11228
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#1515
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Medical Philosophy
Darlene Dixon's Degrees
- Bachelors Biology University of California, Davis
- Doctorate Veterinary Medicine University of California, Davis
- PhD Toxicology Cornell University
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Why Is Darlene Dixon Influential?
(Suggest an Edit or Addition)According to Wikipedia, Darlene Dixon is an American veterinary scientist and toxicologic pathologist researching the pathogenesis/carcinogenesis of tumors affecting the reproductive tract of rodents and humans and assessing the role of environmental and endogenous hormonal factors in the growth of these tumors. She is a senior investigator at the National Institute of Environmental Health Sciences.
Darlene Dixon's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Etiology and pathogenesis of uterine leiomyomas: a review. (2003) (531)
- Classification of Proliferative Pulmonary Lesions of the Mouse (2004) (321)
- Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium. (2004) (268)
- Estrogen Receptor-α Knockout Mice Exhibit Resistance to the Developmental Effects of Neonatal Diethylstilbestrol Exposure on the Female Reproductive Tract (2001) (174)
- Proceedings from the Third National Institutes of Health International Congress on Advances in Uterine Leiomyoma Research: comprehensive review, conference summary and future recommendations. (2014) (142)
- Immortalization of Human Uterine Leiomyoma and Myometrial Cell Lines After Induction of Telomerase Activity: Molecular and Phenotypic Characteristics (2002) (125)
- Nonproliferative and Proliferative Lesions of the Rat and Mouse Female Reproductive System (2014) (108)
- The Placenta in Toxicology. Part II (2014) (104)
- Recommendations from the INHAND Apoptosis/Necrosis Working Group (2016) (104)
- Immunohistochemical localization of growth factors and their receptors in uterine leiomyomas and matched myometrium. (2000) (100)
- Estrogen receptor-alpha knockout mice exhibit resistance to the developmental effects of neonatal diethylstilbestrol exposure on the female reproductive tract. (2001) (90)
- Postnatal Ovary Development in the Rat (2015) (89)
- Differential Expression of Receptor Tyrosine Kinases (RTKs) and IGF-I Pathway Activation in Human Uterine Leiomyomas (2008) (86)
- From the Cover: Three-Dimensional (3D) HepaRG Spheroid Model With Physiologically Relevant Xenobiotic Metabolism Competence and Hepatocyte Functionality for Liver Toxicity Screening (2017) (82)
- Toll-like receptor 4 in butylated hydroxytoluene-induced mouse pulmonary inflammation and tumorigenesis. (2005) (81)
- Estrogen-induced changes in IGF-I, Myb family and MAP kinase pathway genes in human uterine leiomyoma and normal uterine smooth muscle cell lines. (2005) (79)
- Effects of Liver X Receptor Agonist Treatment on Pulmonary Inflammation and Host Defense1 (2008) (78)
- Analysis of genetic alterations in uterine leiomyomas and leiomyosarcomas by comparative genomic hybridization (1997) (75)
- Enhanced susceptibility of staggerer (RORalphasg/sg) mice to lipopolysaccharide-induced lung inflammation. (2005) (73)
- Characterization of Uterine Leiomyomas in CD-1 Mice Following Developmental Exposure to Diethylstilbestrol (DES) (2002) (71)
- Cell proliferation and apoptosis in human uterine leiomyomas and myometria (2002) (71)
- Modulatory Role for Retinoid-related Orphan Receptor α in Allergen-induced Lung Inflammation (2006) (68)
- A low concentration of genistein induces estrogen receptor-alpha and insulin-like growth factor-I receptor interactions and proliferation in uterine leiomyoma cells. (2008) (65)
- What do we need to know prior to thinking about incorporating an epigenetic evaluation into safety assessments? (2010) (60)
- Lung tumors in mice induced by “whole-life” inorganic arsenic exposure at human-relevant doses (2014) (60)
- Stimulatory and inhibitory effects of genistein on human uterine leiomyoma cell proliferation are influenced by the concentration. (2007) (55)
- p53 integrates host defense and cell fate during bacterial pneumonia (2013) (51)
- Three-Dimensional (3D) HepaRG Spheroid Model With Physiologically Relevant Xenobiotic Metabolism Competence and Hepatocyte Functionality for Liver Toxicity Screening. (2017) (48)
- Subchronic Toxicity Studies Indicate that Tris(2-Chloroethyl)Phosphate Administration Results in Lesions in the Rat Hippocampus1 (1990) (47)
- Human uterine leiomyoma-derived fibroblasts stimulate uterine leiomyoma cell proliferation and collagen type I production, and activate RTKs and TGF beta receptor signaling in coculture (2010) (46)
- Advances in uterine leiomyoma research: conference overview, summary, and future research recommendations. (2000) (42)
- Histopathologic changes in the uterus, cervix and vagina of immature CD-1 mice exposed to low doses of perfluorooctanoic acid (PFOA) in a uterotrophic assay. (2012) (40)
- Association of race, age and body mass index with gross pathology of uterine fibroids. (2008) (40)
- Estrogen Regulates MAPK-Related Genes through Genomic and Nongenomic Interactions between IGF-I Receptor Tyrosine Kinase and Estrogen Receptor-Alpha Signaling Pathways in Human Uterine Leiomyoma Cells (2012) (39)
- Glucocorticoids Regulate Gene Expression and Repress Cellular Proliferation in Human Uterine Leiomyoma Cells (2012) (38)
- Estrogen receptor alpha (ERα) phospho-serine-118 is highly expressed in human uterine leiomyomas compared to matched myometrium (2008) (38)
- The Natural History of Uterine Leiomyomas: Light and Electron Microscopic Studies of Fibroid Phases, Interstitial Ischemia, Inanosis, and Reclamation (2013) (37)
- Effects of Neonatal Diethylstilbestrol (DES) Exposure on Morphology and Growth Patterns of Endometrial Epithelial Cells in CD-1 Mice (1999) (37)
- ATP-binding cassette transporter G1 deficiency dysregulates host defense in the lung. (2010) (37)
- Uterine Smooth Muscle Tumors in Potbellied Pigs (Sus scrofa) Resemble Human Fibroids: A Potential Animal Model (2004) (36)
- A high concentration of genistein down-regulates activin A, Smad3 and other TGF-β pathway genes in human uterine leiomyoma cells (2012) (34)
- Retinoid-Related Orphan Receptor γ Controls Immunoglobulin Production and Th1/Th2 Cytokine Balance in the Adaptive Immune Response to Allergen1 (2007) (34)
- Modulatory role for retinoid-related orphan receptor alpha in allergen-induced lung inflammation. (2006) (34)
- Inhibition of lung immunity after intratracheal instillation of benzo(a)pyrene. (1994) (33)
- Molecular Mechanisms of Renal Tissue Repair in Survival from Acute Renal Tubule Necrosis: Role of ERK1/2 Pathway (2003) (32)
- An endocrine-disrupting chemical, fenvalerate, induces cell cycle progression and collagen type I expression in human uterine leiomyoma and myometrial cells. (2010) (32)
- Histomorphology and ultrastructure of spontaneous pulmonary neoplasms in strain A mice. (1991) (30)
- Implanted coil MR microscopy of renal pathology (1989) (30)
- IL-4–secreting eosinophils promote endometrial stromal cell proliferation and prevent Chlamydia-induced upper genital tract damage (2017) (29)
- Summary of Chemically Induced Pulmonary Lesions in the National Toxicology Program (NTP) Toxicology and Carcinogenesis Studies (2008) (29)
- Cadmium and Proliferation in Human Uterine Leiomyoma Cells: Evidence of a Role for EGFR/MAPK Pathways but Not Classical Estrogen Receptor Pathways (2014) (29)
- Inhibition of urethane-induced genotoxicity and cell proliferation in CYP2E1-null mice. (2005) (29)
- Receptor tyrosine kinases and their hormonal regulation in uterine leiomyoma. (2010) (29)
- Erratum: Classification of proliferative pulmonary lesions of the mouse: Recommendations of the mouse models of human cancers consortium (Cancer Research (April 1, 2004) 64 (2307-2316)) (2004) (24)
- Bisphenol A induces human uterine leiomyoma cell proliferation through membrane-associated ERα36 via nongenomic signaling pathways (2019) (23)
- The Placenta in Toxicology. Part IV (2014) (22)
- Abnormal Cell Differentiation and p21 Expression of Endometrial Epithelial Cells Following Developmental Exposure to Diethylstilbestrol (DES) (2000) (22)
- Pulmonary response of Fischer 344 rats to acute nose-only inhalation of indium trichloride. (1994) (21)
- Pulmonary toxicity to intratracheally administered indium trichloride in Fischer 344 rats. (1994) (20)
- Bromoethane, chloroethane and ethylene oxide induced uterine neoplasms in B6C3F1 mice from 2-year NTP inhalation bioassays: pathology and incidence data revisited. (2003) (20)
- Characterization of the expression of the retinoid-related, testis-associated receptor (RTR) in trophoblasts. (2002) (20)
- ERα36, a variant of estrogen receptor α, is predominantly localized in mitochondria of human uterine smooth muscle and leiomyoma cells (2017) (19)
- The Placenta in Toxicology. Part I (2014) (19)
- Incorporation of bromodeoxyuridine (BrdU) in the bronchiolar-alveolar regions of the lungs following two inhalation exposures to chrysotile asbestos in strain A/J mice. (1995) (18)
- Development of Novel Cell Lines for High-Throughput Screening to Detect Estrogen-Related Receptor Alpha Modulators (2017) (17)
- Epigenetic Enzymes, Age, and Ancestry Regulate the Efficiency of Human iPSC Reprogramming (2018) (17)
- The second National Institutes of Health International Congress on advances in uterine leiomyoma research: conference summary and future recommendations. (2006) (17)
- Expression of calmodulin in germ cells is associated with fenvalerate-induced male reproductive toxicity (2012) (16)
- A High Concentration of Genistein Induces Cell Death in Human Uterine Leiomyoma Cells by Autophagy. (2016) (16)
- “Lipomatous” Lesions of Unknown Cellular Origin in the Liver of B6C3F1 Mice (1994) (16)
- The Natural History of Uterine Leiomyomas: Morphometric Concordance with Concepts of Interstitial Ischemia and Inanosis (2013) (15)
- Histomorphologic features of spontaneous and chemically-induced pulmonary neoplasms in B6C3F1 mice and Fischer 344 rats. (1991) (15)
- Pulmonary Toxicity to Intratracheally Administered Indium Trichloride in Fischer 344 Rats (1994) (15)
- Double-stranded RNA-activated protein kinase regulates early innate immune responses during respiratory syncytial virus infection. (2010) (14)
- Disruption of the Estrogen Receptor Gene in Mice† (1997) (14)
- Genistein: Dual Role in Women’s Health (2021) (13)
- Transforming growth factor-alpha, epidermal growth factor receptor, and PCNA immunoexpression in uterine leiomyosarcomas and leiomyomas in B6C3F1 mice. (2000) (13)
- Environmental Factors Involved in Maternal Morbidity and Mortality. (2020) (13)
- Magnetic Resonance Imaging (MRI): A New Tool in Experimental Toxicologic Pathology (1988) (12)
- Scientific and Regulatory Policy Committee (SRPC) Points to Consider* (2015) (11)
- Immunoexpression of Steroid Hormone Receptors and Proliferation Markers in Uterine Leiomyoma and Normal Myometrial Tissues from the Miniature Pig, Sus scrofa (2016) (11)
- Epigenetic regulation of transcription factor promoter regions by low-dose genistein through mitogen-activated protein kinase and mitogen-and-stress activated kinase 1 nongenomic signaling (2016) (11)
- The Placenta in Toxicology. Part III (2014) (10)
- Characterization of Uterine Granular Cell Tumors in B6C3F1 Mice: A Histomorphologic, Immunohistochemical, and Ultrastructural Study (2008) (10)
- Oviduct, Uterus, and Vagina (2018) (10)
- Karyotypic characteristics of human uterine leiomyoma and myometrial cell lines following telomerase induction. (2006) (9)
- Short-term oral administration of polybrominated biphenyls enhances the development of hepatic enzyme-altered foci in initiated rats. (1987) (9)
- Tumor-Promoting, Initiating, and Hepatotoxic Effects of 3,4,3',4'-Tetrabromobiphenyl (34-TBB) in Rats (1988) (9)
- Differential responses to retinoic acid and endocrine disruptor compounds of subpopulations within human embryonic stem cell lines. (2012) (9)
- An essential role of p27 downregulation in fenvalerate-induced cell growth in human uterine leiomyoma and smooth muscle cells. (2012) (8)
- Toxicologic testing methods (2020) (8)
- Juvenile Toxicology (2015) (8)
- Preparation of Three-dimensional (3-D) Human Liver (HepaRG) Cultures for Histochemical and Immunohistochemical Staining and Light Microscopic Evaluation (2018) (7)
- Erratum to: Differential Expression of Receptor Tyrosine Kinases (RTKs) and IGF-I Pathway Activation in Human Uterine Leiomyomas (2008) (7)
- The Life Cycle of the Uterine Fibroid Myocyte (2018) (7)
- Endocrine Disruption and Reproductive Pathology (2019) (7)
- A nongenomic mechanism for “metalloestrogenic” effects of cadmium in human uterine leiomyoma cells through G protein-coupled estrogen receptor (2019) (6)
- Cornerstones of Toxicology (2017) (6)
- Prolonged cadmium exposure alters benign uterine fibroid cell behavior, extracellular matrix components, and TGFB signaling (2021) (6)
- Effects of Hormonally Active Agents on Steroid Hormone Receptor Expression and Cell Proliferation in the Myometrium of Ovariectomized Macaques (2011) (5)
- Characterization of primary mouse hepatocyte spheroids as a model system to support investigations of drug-induced liver injury. (2020) (4)
- Upregulation of estrogen receptor expression in the uterus of ovariectomized B6C3F1 mice and Ishikawa cells treated with bromoethane. (2005) (4)
- Short‐term tetrabromobisphenol A exposure promotes fibrosis of human uterine fibroid cells in a 3D culture system through TGF‐beta signaling (2022) (4)
- Immunogold electron microscopy and confocal analyses reveal distinctive patterns of histone H3 phosphorylation during mitosis in MCF‐7 cells (2016) (4)
- Summary of the Proceedings of the Basic Science of Uterine Fibroids Meeting: New Developments February 28, 2020. (2020) (4)
- “Metalloestrogenic” effects of cadmium downstream of G protein-coupled estrogen receptor and mitogen-activated protein kinase pathways in human uterine fibroid cells (2021) (3)
- Assessment of Hyperplastic Lesions in Rodent Carcinogenicity Studies (2003) (3)
- Dose and dose-response relationships in toxicology (2020) (3)
- Response to letter to the editor by Cohen et al. (2014) “Re: Waalkes et al.: Lung tumors in mice induced by “whole-life” inorganic arsenic exposure at human-relevant doses, Arch Toxicol, 2014” (2014) (3)
- NTP Research Report on Absence of Formaldehyde-Induced Neoplasia in Trp53 Haploinsufficient Mice Exposed by Inhalation (2017) (3)
- An essential role of p 27 downregulation in fenvalerate-induced cell growth in human uterine leiomyoma and smooth muscle cells (2012) (2)
- Tumours of the pancreas. (1994) (2)
- Assessment of hyperplastic lesions in rodent carcinogenicity studies. (2003) (2)
- The basis of selective toxicity (2020) (2)
- INHAND: Nonproliferative and Proliferative Lesions of the Rat and Mouse FemaleReproductive Tract (2014) (2)
- Response to letter to the editor by Cohen et al. (2014) “Re: Waalkes et al.: Lung tumors in mice induced by “whole-life” inorganic arsenic exposure at human-relevant doses, Arch Toxicol, 2014” (2014) (1)
- Immunopathology of the Male Reproductive Tract (2017) (1)
- NTP/NIEHS Global Contributions to Toxicologic Pathology (2017) (1)
- Society of Toxicologic Pathology Position on Assessment of Hyperplastic Lesions in Rodent Carcinogenicity Studies (2004) (1)
- Immunohistochemical Characterization of Sarcomas in Trp53+/− Haploinsufficient Mice (2017) (1)
- Differential receptor tyrosine kinase phosphorylation in the uterus of rats following developmental exposure to tetrabromobisphenol A (2021) (1)
- Evaluation of Cystic Endometrial Hyperplasia and the Normal Estrous Cycle in Longitudinal Sections of Uterus from Female Harlan Sprague-Dawley Rats (2020) (1)
- Comparison of Automated and Manual immunohistochemical, Staining of Bromodeoxyuridine (BrdU)-Labeled Pulmonary Epithelial Cells in Mice (1994) (1)
- A Brief Overview of the STP 35th Annual Symposium on the Basis and Relevance of Variation in Toxicologic Responses (2017) (1)
- Bisphenol A and its analogues induce Fibrosis in a 3D Human Uterine Fibroid Model through TGF‐beta Signaling (2020) (1)
- Epigenetic regulation of transcription factor promoter regions by low-dose genistein through mitogen-activated protein kinase and mitogen-and-stress activated kinase 1 nongenomic signaling (2016) (1)
- Immunopathology of the Female Reproductive Tract and Mammary Gland (2017) (1)
- Abnormal response to chemicals (2020) (0)
- Classification of harmful effects of chemicals (2020) (0)
- Biologic factors that influence toxicity (2020) (0)
- Lung tumors in mice induced by “whole-life” inorganic arsenic exposure at human-relevant doses (2014) (0)
- The basis of antidotal therapy (2020) (0)
- Letter to the Editor (1996) (0)
- Principles of biological tests for toxicity (2020) (0)
- NTP RR 3: Absence of Formaldehyde-Induced Neoplasia in TRP53 Haploinsufficient Mice Exposed by Inhalation; August 2017 (2018) (0)
- Molecules in the Cynomolgus Monkey ( Macaca fascicularis ) The Placenta in Toxicology . Part I : Animal Models in Toxicology : Placental Morphology and Tolerance (2014) (0)
- Chronic PFOA exposure in vitro causes acquisition of multiple tumor cell characteristics in rat liver cells. (2023) (0)
- Chemical factors that influence toxicity (2020) (0)
- Histomorphologic Features of Spontaneous and Chemically-Induced Pulmonary Neoplasms in B6C3F1 Mice and Fischer 344 Rats 1 (1991) (0)
- Host Defense Treatment on Pulmonary Inflammation and Effects of Liver X Receptor Agonist (2008) (0)
- Influence of route of administration on systemic toxicity (2020) (0)
- Uterine Paramesonephric Cysts in Sprague-Dawley Rats from National Toxicology Program Studies (2018) (0)
- 18 Validation of Flow Cytometry-Based Quantitation of Reticulated Platelets in Cynomolgus Monkeys and Wistar Rats (2018) (0)
- Toxic effects of chemicals (2020) (0)
- Introduction, scope, and principles (2020) (0)
- Comparison of Automated and Manual Staining Techniques for the Binding of Wheat Germ Agglutinin (WGA) Modified B5- and Formalin-Fixed Pulmonary Tissue (1991) (0)
- Prolonged Cadmium Exposure Alters Migration Dynamics and Increases Heterogeneity of Human Uterine Fibroid Cells—Insights from Time Lapse Analysis (2022) (0)
- Information sources in toxicology (2020) (0)
- Expression of calmodulin in germ cells is associated with fenvalerate-induced male reproductive toxicity (2012) (0)
- Genetic factors that influence toxicity (2020) (0)
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