Darryle D. Schoepp
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Darryle D. Schoepp's Degrees
- PhD Pharmacology University of California, San Francisco
- Doctorate Medicine Stanford University
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(Suggest an Edit or Addition)Darryle D. Schoepp's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Pharmacological agents acting at subtypes of metabotropic glutamate receptors (1999) (1057)
- Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial (2007) (1029)
- Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo (2005) (979)
- Regulation of Neurotransmitter Release by Metabotropic Glutamate Receptors (2000) (898)
- Metabotropic glutamate receptors in brain function and pathology. (1993) (805)
- Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system. (2001) (719)
- Metabotropic glutamate receptors as novel targets for anxiety and stress disorders (2005) (604)
- Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo. (2005) (595)
- Metabotropic glutamate receptors: From the workbench to the bedside (2011) (562)
- Pharmacological and functional characteristics of metabotropic excitatory amino acid receptors. (1990) (462)
- A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission (1997) (424)
- LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors (1998) (360)
- Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): a potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties. (1997) (352)
- Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex. (2000) (280)
- The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-amphetamine motor behaviors in rats. (1999) (278)
- Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors. (1998) (277)
- Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors. (1999) (269)
- 3,5‐Dihydroxyphenylglycine Is a Highly Selective Agonist for Phosphoinositide‐Linked Metabotropic Glutamate Receptors in the Rat Hippocampus (1994) (261)
- LY354740, an mGlu2/3 Receptor Agonist as a Novel Approach to Treat Anxiety/Stress (2003) (206)
- LY354740 is a Potent and Highly Selective Group II Metabotropic Glutamate Receptor Agonist in Cells Expressing Human Glutamate Receptors (1997) (198)
- Evidence for the Role of Metabotropic Glutamate (mGlu)2 Not mGlu3 Receptors in the Preclinical Antipsychotic Pharmacology of the mGlu2/3 Receptor Agonist (–)-(1R,4S,5S,6S)-4-Amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic Acid (LY404039) (2008) (193)
- Activation of hippocampal metabotropic excitatory amino acid receptors leads to seizures and neuronal damage (1992) (191)
- Activity of 2,3-benzodiazepines at Native Rat and Recombinant Human Glutamate Receptors In Vitro: Stereospecificity and Selectivity Profiles (1996) (189)
- Excitatory Amino Acid Agonist‐Antagonist Interactions at 2‐Amino‐4‐Phosphonobutyric Acid‐Sensitive Quisqualate Receptors Coupled to Phosphoinositide Hydrolysis in Slices of Rat Hippocampus (1988) (185)
- In vivo inhibition of veratridine-evoked release of striatal excitatory amino acids by the group II metabotropic glutamate receptor agonist LY354740 in rats (1997) (170)
- Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine. (2003) (170)
- The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity (1998) (169)
- Inhibition of Cyclic AMP Formation by a Selective Metabotropic Glutamate Receptor Agonist (1992) (162)
- A major role for thalamocortical afferents in serotonergic hallucinogen receptor function in the rat neocortex (2001) (156)
- Translating Glutamate: From Pathophysiology to Treatment (2011) (153)
- Preparative methods for brain slices: a discussion (1995) (153)
- Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s) (2005) (149)
- In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disorders (2007) (145)
- Metabotropic glutamate receptors in the control of mood disorders. (2007) (141)
- Induction or protection of limbic seizures in mice by mGluR subtype selective agonists (1995) (139)
- (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord (2001) (139)
- Novel functions for subtypes of metabotropic glutamate receptors (1994) (135)
- AMPA/Kainate Antagonist LY293558 Reduces Capsaicin‐evoked Hyperalgesia but Not Pain in Normal Skin in Humans (1998) (125)
- Efficacy and Tolerability of an mGlu2/3 Agonist in the Treatment of Generalized Anxiety Disorder (2008) (122)
- Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice (2005) (121)
- Metabotropic Glutamate Receptor Activation Produces Extrapyramidal Motor System Activation That Is Mediated by Striatal Dopamine (1992) (120)
- Attenuation of specific PCP-evoked behaviors by the potent mGlu2/3 receptor agonist, LY379268 and comparison with the atypical antipsychotic, clozapine (2000) (117)
- Inhibition of Excitatory Amino Acid‐Stimulated Phosphoinositide Hydrolysis in the Neonatal Rat Hippocampus by 2‐Amino‐3‐Phosphonopropionate (1989) (116)
- Stereoselectivity and mode of inhibition of phosphoinositide-coupled excitatory amino acid receptors by 2-amino-3-phosphonopropionic acid. (1990) (111)
- Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. (1998) (103)
- The metabotropic excitatory amino acid receptor agonist 1S,3R-ACPD selectively potentiates N-methyl-D-aspartate-induced brain injury. (1992) (102)
- Discovery of a potent, peripherally selective trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonist for the treatment of gastrointestinal motility disorders. (1994) (101)
- LY354740: a metabotropic glutamate receptor agonist which ameliorates symptoms of nicotine withdrawal in rats (1997) (101)
- (3SR,4aRS,6RS,8aRS)-6-[2-(1H-tetrazol-5-yl)ethyl]decahydroisoquinoline-3 - carboxylic acid: a structurally novel, systemically active, competitive AMPA receptor antagonist. (1993) (99)
- Pharmacological discrimination of GluR5 and GluR6 kainate receptor subtypes by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahyd roisdoquinoline-3 carboxylic-acid. (1996) (99)
- Increased anxiety-related behavior in mice deficient for metabotropic glutamate 8 (mGlu8) receptor (2002) (98)
- Metabotropic glutamate receptors (1994) (97)
- The Novel Metabotropic Glutamate Receptor Agonist 2R,4R-APDC Potentiates Stimulation of Phosphoinositide Hydrolysis in the Rat Hippocampus by 3,5-dihydroxyphenylglycine: Evidence for a Synergistic Interaction Between Group 1 and Group 2 Receptors (1996) (95)
- [3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells (1999) (95)
- Design, Synthesis, and Pharmacological Characterization of (+)-2- Aminobicyclo(3.1.0)hexane-2,6-dicarboxylic Acid (LY354740): A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvulsant and Anxiolytic Properties. (1997) (95)
- [3H]LY341495 binding to group II metabotropic glutamate receptors in rat brain. (2001) (93)
- Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanism of action in vivo. (2000) (93)
- 2-substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioavailability. (1998) (92)
- The metabotropic glutamate 2/3 receptor agonist LY404039 reduces alcohol-seeking but not alcohol self-administration in alcohol-preferring (P) rats (2006) (92)
- Neuroprotection by metabotropic glutamate receptor agonists: LY354740, LY379268 and LY389795 (1999) (89)
- The mGlu(2/3) receptor agonist LY379268 selectively blocks amphetamine ambulations and rearing. (2000) (88)
- Endothelium-dependent modulation of angiotensin II-induced contraction in blood vessels. (1988) (88)
- Intrastriatal injection of a selective metabotropic excitatory amino acid receptor agonist induces contralateral turning in the rat. (1991) (86)
- CNS distribution of metabotropic glutamate 2 and 3 receptors: Transgenic mice and [3H]LY459477 autoradiography (2013) (83)
- Pharmacological and Pharmacokinetic Properties of a Structurally Novel, Potent, and Selective Metabotropic Glutamate 2/3 Receptor Agonist: In Vitro Characterization of Agonist (–)-(1R,4S,5S,6S)-4-Amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic Acid (LY404039) (2007) (82)
- Comparison of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD)- and 1R,3S-ACPD-stimulated brain phosphoinositide hydrolysis. (1991) (81)
- Selective inhibition of excitatory amino acid-stimulated phosphoinositide hydrolysis in the rat hippocampus by activation of protein kinase C. (1988) (80)
- Schizophrenia: moving beyond monoamine antagonists. (2008) (80)
- Comparison of Excitatory Amino Acid‐Stimulated Phosphoinositide Hydrolysis and N‐[3H]Acetylaspartylglutamate Binding in Rat Brain: Selective Inhibition of Phosphoinositide Hydrolysis by 2‐Amino‐3‐Phosphonopropionate (1989) (79)
- The Rapidly Acting Antidepressant Ketamine and the mGlu2/3 Receptor Antagonist LY341495 Rapidly Engage Dopaminergic Mood Circuits (2016) (78)
- Selective inhibition of forskolin-stimulated cyclic AMP formation in rat hippocampus by a novel mGluR agonist, 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate (1995) (77)
- Cloning and expression of a human metabotropic glutamate receptor 1 alpha: enhanced coupling on co-transfection with a glutamate transporter. (1995) (74)
- Excitatory amino acid-induced convulsions in neonatal rats mediated by distinct receptor subtypes. (1990) (70)
- The anxiolytic action of mGlu2/3 receptor agonist, LY354740, in the fear-potentiated startle model in rats is mechanistically distinct from diazepam (2002) (69)
- A novel, competitive mGlu5 receptor antagonist (LY344545) blocks DHPG‐induced potentiation of NMDA responses but not the induction of LTP in rat hippocampal slices (2000) (68)
- Norepinephrine Stimulation of Phosphoinositide Hydrolysis in Rat Cerebral Cortex Is Associated with the Alpha1‐Adrenoceptor (1984) (68)
- Pharmacological Characterization of the Competitive GLUK5 Receptor Antagonist Decahydroisoquinoline LY466195 in Vitro and in Vivo (2006) (66)
- D,L-(tetrazol-5-yl) glycine: a novel and highly potent NMDA receptor agonist. (1991) (65)
- Tolerance to the motor impairment, but not to the reversal of PCP-induced motor activities by oral administration of the mGlu2/3 receptor agonist, LY379268 (1999) (64)
- 2-Substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 1. Effects of alkyl, arylalkyl, and diarylalkyl substitution. (1998) (64)
- 4-(Tetrazolylalkyl)piperidine-2-carboxylic acids. Potent and selective N-methyl-D-aspartic acid receptor antagonists with a short duration of action. (1991) (64)
- In vitro and in vivo antagonism of AMPA receptor activation by (3s,4ar,6r,8ar)-6-[2-(1(2)h-tetrazole-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid (1995) (63)
- Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl)glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes (2000) (63)
- In Vitro and In Vivo Pharmacology of trans‐ and cis‐(±)‐1‐Amino‐1,3‐Cyclopentanedicarboxylic Acid: Dissociation of Metabotropic and Ionotropic Excitatory Amino Acid Receptor Effects (1991) (61)
- Improved Bioavailability of the mGlu2/3 Receptor Agonist LY354740 Using a Prodrug Strategy: In Vivo Pharmacology of LY544344 (2006) (60)
- Dipeptides as effective prodrugs of the unnatural amino acid (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740), a selective group II metabotropic glutamate receptor agonist. (2005) (60)
- Neuroprotective Actions of Novel and Potent Ligands of Group I and Group II Metabotropic Glutamate Receptors (1999) (59)
- Acute increases in monoamine release in the rat prefrontal cortex by the mGlu2/3 agonist LY379268 are similar in profile to risperidone, not locally mediated, and can be elicited in the presence of uptake blockade (2001) (58)
- The Group II Metabotropic Glutamate Receptor Agonist (−)-2-Oxa-4-aminobicyclo[3.1.0.]hexane-4,6-dicarboxylate (LY379268) and Clozapine Reverse Phencyclidine-Induced Behaviors in Monoamine-Depleted Rats (2002) (57)
- Neurochemical effects of the M1 muscarinic agonist xanomeline (LY246708/NNC11-0232). (1994) (56)
- Synthesis and metabotropic glutamate receptor activity of S-oxidized variants of (-)-4-amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate: identification of potent, selective, and orally bioavailable agonists for mGlu2/3 receptors. (2007) (55)
- Molecular Cloning, Expression, and Pharmacological Characterization of humEAA1, a Human Kainate Receptor Subunit (1994) (52)
- Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase. (1996) (52)
- Methyl substitution of 2-aminobicyclo[3.1.0]hexane 2,6-dicarboxylate (LY354740) determines functional activity at metabotropic glutamate receptors: identification of a subtype selective mGlu2 receptor agonist. (2005) (51)
- The selective group mGlu2/3 receptor agonist LY379268 suppresses REM sleep and fast EEG in the rat (2002) (50)
- SAR study of a subtype selective allosteric potentiator of metabotropic glutamate 2 receptor, N-(4-phenoxyphenyl)-N-(3-pyridinylmethyl)ethanesulfonamide. (2004) (50)
- Synthesis and excitatory amino acid pharmacology of a series of heterocyclic-fused quinoxalinones and quinazolinones. (1992) (49)
- Intracerebral 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) produces limbic seizures that are not blocked by ionotropic glutamate receptor antagonists (1993) (48)
- Effects of mGlu2 or mGlu3 receptor deletions on mGlu2/3 receptor agonist (LY354740)-induced brain c-Fos expression: Specific roles for mGlu2 in the amygdala and subcortical nuclei, and mGlu3 in the hippocampus (2006) (48)
- Metabotropic glutamate receptor modulation of cAMP accumulation in the neonatal rat hippocampus (1993) (47)
- Dopamine and 5-HT turnover are increased by the mGlu2/3 receptor agonist LY379268 in rat medial prefrontal cortex, nucleus accumbens and striatum (2000) (47)
- Pharmacology of metabotropic glutamate receptor inhibition of cyclic AMP formation in the adult rat hippocampus (1993) (47)
- Aurintricarboxylic Acid Prevents NMDA‐Mediated Excitotoxicity: Evidence for Its Action as an NMDA Receptor Antagonist (1993) (46)
- (2S,4S)-2-amino-4-(4,4-diphenylbut-1-yl)- pentane-1,5-dioic acid: a potent and selective antagonist for metabotropic glutamate receptors negatively linked to adenylate cyclase. (1996) (45)
- Effects of Intrastriatal Kainic Acid Injection on [3H]Dopamine Metabolism in Rat Striatal Slices: Evidence for Postsynaptic Glial Cell Metabolism by Both the Type A and B Forms of Monoamine Oxidase (1983) (44)
- 1S,3R-ACPD-sensitive (metabotropic) [3H]glutamate receptor binding in membranes (1992) (43)
- Efficacy and Tolerability of an mGlu2/3 Agonist in the Treatment of Generalized Anxiety Disorder (2008) (42)
- Effects of the selective metabotropic glutamate agonist LY354740 in a rat model of permanent ischaemia (1998) (40)
- Inhibition of group I metabotropic glutamate receptor responses in vivo in rats by a new generation of carboxyphenylglycine-like amino acid antagonists (2002) (39)
- Glutamate—Hypothalamic-Pituitary-Adrenal Axis Interactions: Implications for Mood and Anxiety Disorders (2001) (39)
- A novel, competitive mGlu(5) receptor antagonist (LY344545) blocks DHPG-induced potentiation of NMDA responses but not the induction of LTP in rat hippocampal slices. (2000) (39)
- Comparison of c-Fos induction in the brain by the mGlu2/3 receptor antagonist LY341495 and agonist LY354740: Evidence for widespread endogenous tone at brain mGlu2/3 receptors in vivo (2005) (39)
- Alzheimer's disease research and development: a call for a new research roadmap (2014) (39)
- Cyclothiazide acts at a site on the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor complex that does not recognize competitive or noncompetitive AMPA receptor antagonists. (1995) (38)
- [3H]LY341495, a highly potent, selective and novel radioligand for labeling Group II metabotropic glutamate receptors. (1998) (38)
- The biochemical pharmacology of metabotropic glutamate receptors. (1993) (37)
- The Metabotropic Glutamate (mGLU)2/3 Receptor Antagonist LY341495 [2S-2-Amino-2-(1S,2S-2-carboxycyclopropyl-1-yl)-3-(xanth-9-yl)propanoic Acid] Stimulates Waking and Fast Electroencephalogram Power and Blocks the Effects of the mGLU2/3 Receptor Agonist LY379268 [(-)-2-Oxa-4-aminobicyclo[3.1.0]hexane (2005) (37)
- A Role for Noradrenergic Transmission in the Actions of Phencyclidine and the Antipsychotic and Antistress Effects of mGlu2/3 Receptor Agonists (2003) (37)
- Structure-activity studies of 6-(tetrazolylalkyl)-substituted decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists. 1. Effects of stereochemistry, chain length, and chain substitution. (1996) (36)
- Effects of the mGlu2/3 receptor agonist LY379268 on motor activity in phencyclidine-sensitized rats (2002) (36)
- Distribution and Ontogeny of 1S,3R‐1‐Aminocyclopentane‐1,3‐Dicarboxylic Acid‐Sensitive and Quisqualate‐Insensitive [3H]Glutamate Binding Sites in the Rat Brain (1994) (36)
- Role of type A and type B monoamine oxidase in the metabolism of released [3H]dopamine from rat striatal slices. (1982) (35)
- Molecular structure and pharmacological characterization of humEAA2, a novel human kainate receptor subunit. (1992) (35)
- Metabotropic glutamate receptor targets for neuropsychiatric disorders (2006) (34)
- Systemic administration of the potent mGlu8 receptor agonist (S)-3,4-DCPG induces c-Fos in stress-related brain regions in wild-type, but not mGlu8 receptor knockout mice (2003) (33)
- 6-substituted decahydroisoquinoline-3-carboxylic acids as potent and selective conformationally constrained NMDA receptor antagonists. (1992) (32)
- The mGlu2/3 receptor agonist LY379268 injected into cortex or thalamus decreases neuronal injury in retrosplenial cortex produced by NMDA receptor antagonist MK-801: possible implications for psychosis (2004) (32)
- Manganese Stimulates the Incorporation of [3H]Inositol into a Pool of Phosphatidylinositol in Brain That Is Not Coupled to Agonist‐Induced Hydrolysis (1985) (32)
- Increased c-Fos expression in the centromedial nucleus of the thalamus in metabotropic glutamate 8 receptor knockout mice following the elevated plus maze test (2003) (31)
- Enzymatic resolution and pharmacological activity of the enantiomers of 3,5-dihydroxyphenylglycine, a metabotropic glutamate receptor agonist (1995) (31)
- Differentiation of group 2 and group 3 metabotropic glutamate receptor cAMP responses in the rat hippocampus. (1996) (29)
- Corrigenda: Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial (2007) (29)
- Structure-activity studies of 6-substituted decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists. 2. Effects of distal acid bioisosteric substitution, absolute stereochemical preferences, and in vivo activity. (1996) (29)
- DL-tetrazol-5-ylglycine, a highly potent NMDA agonist: its synthesis and NMDA receptor efficacy. (1992) (29)
- Potent, stereoselective, and brain region selective modulation of second messengers in the rat brain by (+)LY354740, a novel group II metabotropic glutamate receptor agonist (1998) (29)
- Evaluation of the activity of a novel metabotropic glutamate receptor antagonist (±)-2-amino-2-(3-cis and trans-carboxycyclobutyl-3-(9-thioxanthyl)propionic acid) in the in vitro neonatal spinal cord and in an in vivo pain model (1999) (29)
- (2S,1'S,2'R,3'R)-2-(2'-Carboxy-3'-hydroxymethylcyclopropyl) glycine is a highly potent group 2 and 3 metabotropic glutamate receptor agonist with oral activity. (2004) (28)
- Second-messenger responses in brain slices to elucidate novel glutamate receptors (1995) (28)
- (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine is a potent and selective metabotropic group 2 receptor agonist with anxiolytic properties. (2002) (28)
- Receptor Subtypes Linked to Metabotropic Glutamate Receptor Agonist‐Mediated Limbic Seizures in Mice (1995) (27)
- Endothelium enhances tachyphylaxis to angiotensins II and III in rat aorta. (1987) (25)
- Alteration of Dopamine Synthesis in Rat Striatum Subsequent to Selective Type A Monoamine Oxidase Inhibition (1981) (25)
- Use of MGLUR2 and MGLUR3 knockout mice to explore in vivo receptor specificity of the MGLUR2/3 selective antagonist LY341495 (2009) (25)
- Contractile serotonin-2A receptor signal transduction in guinea pig trachea: importance of protein kinase C and extracellular and intracellular calcium but not phosphoinositide hydrolysis. (1994) (24)
- Pharmacological characterization of desensitization in a human mGlulα‐expressing non‐neuronal cell line co‐transfected with a glutamate transporter (1996) (24)
- Comparison of contractions to serotonin, carbamylcholine and prostaglandin F2 alpha in rat stomach fundus. (1989) (24)
- 1-BCP, a memory-enhancing agent, selectively potentiates AMPA-induced [3H]norepinephrine release in rat hippocampal slices (1995) (23)
- 5-Hydroxytryptamine2A (5-HT2A) receptor regulation in rat prefrontal cortex: Interaction of a phenethylamine hallucinogen and the metabotropic glutamate2/3 receptor agonist LY354740 (2006) (22)
- Comparison of postnatal changes in alpha 1-adrenoceptor binding and adrenergic stimulation of phosphoinositide hydrolysis in rat cerebral cortex. (1985) (21)
- Synthesis, structure elucidation, and pharmacological evaluation of 5-methyl-oxymorphone (=4,5α-epoxy-3,14-dihydroxy-5,17-dimethylmorphinan-6-one) (1988) (21)
- Where will new neuroscience therapies come from? (2011) (20)
- Structure-activity studies of aryl-spaced decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists (1997) (20)
- Metabotropic glutamate receptors and neuronal degenerative disorders (1994) (20)
- Excitotoxicity at Both NMDA and Non‐NMDA Glutamate Receptors Is Antagonized by Aurintricarboxylic Acid: Evidence for Differing Mechanisms of Action (1995) (19)
- Tetrazole amino acids as competitive NMDA antagonists (1993) (19)
- Synthesis and structure-activity relationship studies of novel 2-diarylethyl substituted (2-carboxycycloprop-1-yl)glycines as high-affinity group II metabotropic glutamate receptor ligands. (2003) (19)
- Synthesis of a mGluR5 antagonist using [11C]copper(I) cyanide (2006) (19)
- Neuroprotectant effects of LY 274614, a structurally novel systemically active competitive NMDA receptor antagonist (2005) (18)
- EARLY CLINICAL RESULTS AND PRECLINICAL VALIDATION OF THE O-GLCNACASE (OGA) INHIBITOR MK-8719 AS A NOVEL THERAPEUTIC FOR THE TREATMENT OF TAUOPATHIES (2016) (18)
- Synthesis and pharmacological characterization of l-trans-4-tetrazolylproline (ly300020): A novel systemically-active ampa receptor agonist (1993) (18)
- (2S,4S)-amino-4-(2,2-diphenylethyl)pentanedioic acid selective group 2 metabotropic glutamate receptor antagonist. (1998) (18)
- Neuroprotection by metabotropic glutamate receptor glutamate receptor agonists: LY354740, LY379268 and LY389795. (1999) (18)
- Pharmacological characterization of LY233053: a structurally novel tetrazole-substituted competitive N-methyl-D-aspartic acid antagonist with a short duration of action. (1990) (17)
- Neonatal exposure to D,L-2-amino-3-phosphonopropionate (D,L-AP3) produces lesions in the eye and optic nerve of adult rats. (1993) (16)
- Effects of LY354740, a Novel Glutamatergic Metabotropic Agonist, on Nonhuman Primate Hypothalamic-Pituitary-Adrenal Axis and Noradrenergic Function (2001) (16)
- Aminooxyacetic acid produces excitotoxic brain injury in neonatal rats (1993) (16)
- Reversible and irreversible neuronal injury induced by intrahippocampal infusion of the mGluR agonist 1S,3R-ACPD in the rat. (1995) (15)
- Thyrotropin-releasing hormone (protirelin) inhibits potassium-stimulated glutamate and aspartate release from hippocampal slices in vitro (2005) (15)
- In vivo 2-amino-3-phosphonopropionic acid administration to neonatal rats selectively inhibits metabotropic excitatory amino acid receptors ex vivo in brain slices (1991) (14)
- Protein kinase C-mediated inhibition of excitatory amino acid-stimulated phosphoinositide hydrolysis in the neonatal rat hippocampus (1989) (14)
- NMDA antagonist activity of (+/-)-(2SR,4RS)-4-(1H-tetrazol-5-ylmethyl)piperidine-2-carboxylic acid resides with the (-)-2R,4S-isomer. (1992) (14)
- Heteroatom-substitution as a strategy for increasing the potency of competitive NMDA antagonists. (1998) (14)
- LY3 54740: A Systemically Active mGlu2/mGlu3 Receptor Agonist (2006) (13)
- (3SR,4aRS,6SR,8aRS)-6-(1H-tetrazol-5-yl)decahydroisoquinoline-3-carboxylic acid, a novel, competitive, systemically active NMDA and AMPA receptor antagonist. (1995) (12)
- Synthesis and metabotropic glutamate receptor antagonist activity of N1-substituted analogs of 2R,4R-4-aminopyrrolidine-2,4-dicarboxylic acid. (1998) (12)
- Disruption of Potential α‐Helix in the G Loop of the Guinea: Pig 5‐Hydroxytryptamine2 Receptor Does Not Prevent Receptor Coupling to Phosphoinositide Hydrolysis (1994) (11)
- 2,3'-disubstituted-2-(2'-carboxycyclopropyl)glycines as potent and selective antagonists of metabotropic glutamate receptors. (1998) (10)
- Pharmacological Properties of Metabotropic Glutamate Receptors (1994) (9)
- Relationship between developmental changes in angiotensin II-induced contractions and stimulation of phosphatidylinositol labeling of rat aorta. (1984) (9)
- C3'-cis-Substituted carboxycyclopropyl glycines as metabotropic glutamate 2/3 receptor agonists: synthesis and SAR studies. (2005) (8)
- Estrogen modulation of angiotensin-stimulated phosphoinositide hydrolysis in slices of rat anterior pituitary (1987) (8)
- Chapter 6. Recent Progress in Excitatory Amino Acid Research (1994) (7)
- The NMDA receptor agonist DL-(tetrazol-5-yl)glycine is a highly potent excitotoxin. (1994) (7)
- Metabotropic glutamate receptors (2002) (7)
- [H]LY341495 Binding to Group II Metabotropic Glutamate Receptors in Rat Brain (2001) (6)
- Group II Metabotropic Glutamate Receptors (mGlu2 and mGlu3) (2008) (6)
- Chapter 1. Metabotropic glutamate receptor modulators: Recent advances and therapeutic potential (2000) (6)
- Unusual stereochemical preferences of decahydroisoquinoline-3-cargoxylic acid competitive NMDA antagonists (1993) (6)
- Striatal quinolinic acid lesions increase [3H]WIN 35,428 binding to the dopamine transporter (1992) (6)
- LY 354740 : A Systemically Active mGlu 2 / mGlu 3 Receptor Agonist (1999) (5)
- Synthesis of the Four Isomers of 4‐Aminopyrrolidine‐2,4‐dicarboxylate: Identification of a Potent, Highly Selective, and Systemically‐Active Agonist for Metabotropic Glutamate Receptors Negatively Coupled to Adenylate Cyclase. (1996) (5)
- Muscarinic antagonist activity of 3-(5-alkoxy-oxazol-2-yl)-1,2,5,6-tetrahydropyridines. (1994) (5)
- Pharmacology of metabotropic glutamate receptors (2001) (5)
- Evaluation of [3H]LY341495 for labeling group II metabotropic glutamate receptors in vivo. (2003) (5)
- Discovery of a Potent, Peripherally Selective trans-3,4-Dimethyl-4-(3- hydroxyphenyl)piperidine Opioid Antagonist for the Treatment of Gastrointestinal Motility Disorders. (1994) (5)
- Cortical influences of serotonin and glutamate on layer V pyramidal neurons. (2021) (5)
- Novel antagonists for metabotropic glutamate receptors (1996) (4)
- Pharmacokinetics of Gold Sodium Thiomalate in Rabbits (1987) (4)
- Abstracts of the International Symposium Excitatory Amino Acids "Ten Years Later" held in Manaus, Brazil on November 1922, 1998 (1998) (4)
- CGS-19755 and MK-801 selectively prevent rat striatal cholinergic and gabaergic neuronal degeneration induced by N-methyl-D-aspartate and ibotenate in vivo (2005) (4)
- (2S,1'S,2'R,3'R)-2(2'-Carboxy-3'-hydroxymethylcyclopropyl)glycine-[3H], a potent and selective radioligand for labeling group 2 and 3 metabotropic glutamate receptors. (2005) (3)
- Improved Bioavailability of the mGlu 2 / 3 Receptor Agonist LY 354740 Using a Prodrug Strategy : In Vivo Pharmacology of LY 544344 (2005) (3)
- Control of neurotransmitter release by metabotropic glutamate receptors (2002) (3)
- (2S,4S)-2-Amino-4-(2,2-diphenylethyl)pentanedioic Acid Selective Group 2 Metabotropic Glutamate Receptor Antagonist. (1998) (3)
- Metabotropic glutamate receptors, 5 years on (2017) (3)
- Metabotropic glutamate receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database (2019) (2)
- Selective protection against AMPA- and kainate-evoked neurotoxicity by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid (LY293558) and its racemate (LY215490) (2005) (2)
- 5-Methylated naloxone, naltrexone, oxymorphone, and their 14-O-methyl ethers. (1990) (2)
- Enzymatic Resolution and Pharmacological Activity of the Enantiomers of 3,5-Dihydroxyphenylglycine, a Metabotropic Glutamate Receptor Agonist. (1995) (2)
- Muscarinic Antagonist Activity of 3‐(5‐Alkoxy‐oxazol‐2‐yl)‐1,2,5,6‐ tetrahydropyridines. (1995) (2)
- Corrigendum to “(2S,1′S,2′R,3′R)-2(2′-Carboxy-3′-hydroxymethylcyclopropyl)glycine–[3H], a potent and selective radioligand for labeling group 2 and 3 metabotropic glutamate receptors” [Bioorg. Med. Chem. Lett. 15 (2005) 349] (2005) (1)
- INTRACEREBRAL INJECTIONS OF METABOTROPIC GLUTAMATE RECEPTOR AGONISTS CAN INDUCE OR PROTECT AGAINST LIMBIC SEIZURES IN MICE (1995) (1)
- Development of metabotropic glutamate receptor subtype selective drugs (1999) (1)
- S.08.01 The metabotropic glutamate receptor progress towards novel therapeutics (2003) (1)
- Translating Glutamate : From Pathophysiology to Treatment Citation Javitt (2012) (1)
- Agonists and antagonists of metabotropic glutamate receptor subtypes as anticonvulsant agents (1996) (1)
- SAR Study of a Subtype Selective Allosteric Potentiator of Metabotropic Glutamate 2 Receptor, N‐(4‐Phenoxyphenyl)‐N‐(3‐pyridinylmethyl)ethanesulfonamide. (2004) (1)
- Presynaptic modulation of excitatory amino acid release: An in vivo microdialysis study (1996) (1)
- (3 S ,4a R ,6 R ,8a R )-6-[2-(1(2) H -Tetrazole-5-yl) ethyl]decahydroisoquinoline-3-carboxylic Acid (LY293558) and its Racemate (LY215490): A Selective and Competitive AMPA/Kainate Receptor Antagonist (1997) (1)
- LY233053: a structurally novel, potent and selective competitive N-methyl-D-aspartate receptor antagonist. (1990) (1)
- 2008 Eruptions in metabotropic glutamate receptors (2008) (1)
- Structure‐Activity Studies of 6‐(Tetrazolylalkyl)‐Substituted Decahydroisoquinoline‐3‐carboxylic Acid AMPA Receptor Antagonists. Part 1. Effects of Stereochemistry, Chain Length, and Chain Substitution. (2010) (1)
- Synthesis, Structure Elucidation, and Pharmacological Evaluation of 5-Methyl-oxymorphone (= 4,5α-Epoxy-3,14-dihydroxy-5,17-dimethylmorphinan-6-one). (1989) (1)
- 2-aminobicyclo [3.1.0] hexane-2,6-dicarboxylic acid compounds (1995) (0)
- CHAPTER 22:Future Drug Discovery for Psychiatric Disorders (2012) (0)
- in or relating to antagonists of excitatory amino acid receptors improvements. (1992) (0)
- Synthesis and metabotropic activity of [3.2.0] and [3.1.0] bicyclo glutamate analogues (1996) (0)
- The effects of the selective group II metabotropic glutamate receptor agonist LY354740 on local cerebral glucose metabolism in the rat brain (1998) (0)
- Stimulation of phosphoinositide hydrolysis by a novel substance partially purified from rat and bovine brain (1986) (0)
- Improvements in or relating to excitatory amino acid receptor (1992) (0)
- Synthetic amino acids stimulable (1995) (0)
- 2,3′‐Disubstituted‐2‐(2′‐carboxycyclopropyl)glycines as Potent and Selective Antagonists of Metabotropic Glutamate Receptors. (1999) (0)
- Aspartic acid derivatives or homologs thereof, and their use in treating neurological disorders (1994) (0)
- Metabotropic glutamate receptors in GtoPdb v.2021.3 (2021) (0)
- BEHAVIORAL EFFECTS OF COMPOUNDS ACTING AT SUBTYPES OF METABOTROPIC GLUTAMATE RECEPTORS (1995) (0)
- JPET #76547 1 The mGLU2/3 receptor antagonist LY341495 stimulates waking and fast EEG power and blocks the effects of the mGLU2/3 receptor agonist LY379268 in rats (2004) (0)
- P.3.027 Activity in the fear-potentiated startle (FPS) in rodents and healthy subjects with LY354740, a novel mGlu2/3 receptor agonist (2003) (0)
- Synthesis and Characterization of Phosphonic Acid-Substituted Amino Acids as Excitatory Amino Acid Receptor Antagonists (1996) (0)
- Molecular cloning, functional expression and pharmacological properties of human metabotropic glutamate receptors 4 and 7 (1996) (0)
- (3SR,4aRS,6SR,8aRS)-6-(1H-Tetrazol-5-yl)decahydroisoquinoline-3- carboxylic Acid, a Novel, Competitive, Systemically Active NMDA, and AMPA Receptor Antagonist. (1996) (0)
- Agonists and Antagonists for Metabotropic Glutamate Receptors (1995) (0)
- Pyrrolidinyldicarbonsäure derivatives for use as metabotropic glutamate receptor antagonists (1995) (0)
- Neuroprotective Actions of Novel and Potent Agonists of Group II Metabotropic Glutamate Receptors (2006) (0)
- Neuroprotective effects of mGlu receptor agonists (1999) (0)
- Discovery of LY314582 and its (+) enantiomer, LY354740: Highly potent and selective group 2 metabotropic glutamate receptor agonists (1996) (0)
- (3S,4aR,6R,8aR)-6-[2-(1(2)H-Tetrazole-5-yl) ethyl]decahydroisoquinoline-3-carboxylic Acid (LY293558) and its Racemate (LY215490) (1997) (0)
- 14. Second messenger responses in brain slices to elucidate novel glutamate receptors (1994) (0)
- Synthesis and Metabotropic Glutamate Receptor Antagonist Activity of N1-Substituted Analogues of 2R,4R-4-Aminopyrrolidine-2,4-dicarboxylic Acid. (1998) (0)
- A Neurochemical Approach to Elucidate Metabotropic vs. Ionotropic Glutamate Receptor Activities in Rat Hippocampal Slices (2020) (0)
- S.08.05 New directions in the drug treatment of schizophrenia: metabotropic glutamate receptors (2006) (0)
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