David A. Agard

Q: What Schools Are Affiliated With David A. Agard

David A. Agard is affiliated with the following schools: Kyoto Institute of Technology, San Diego State University, University of Florida, University of California, San Francisco, University of Massachusetts

David A. Agard's AcademicInfluence.com Rankings

David A. Agard

Physics

#3170

World Rank

#4544

Historical Rank

Biophysics

#83

World Rank

#88

Historical Rank

physics Degrees

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Physics

David A. Agard's Degrees

PhD Biophysics University of California, Berkeley
Bachelors Physics University of California, Berkeley

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David A. Agard's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy (2017) (4591)
Microtubule nucleation by γ-tubulin complexes (2011) (3079)
A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug-Repurposing (2020) (3012)
The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen (1998) (2498)
Electron counting and beam-induced motion correction enable near atomic resolution single particle cryoEM (2013) (1658)
Three-dimensional resolution doubling in wide-field fluorescence microscopy by structured illumination. (2008) (1290)
Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin (2017) (1086)
Subdiffraction Multicolor Imaging of the Nuclear Periphery with 3D Structured Illumination Microscopy (2008) (1063)
Estrogen receptor pathways to AP-1 (2000) (934)
Fluorescence microscopy in three dimensions. (1989) (700)
Interphase chromosomes undergo constrained diffusional motion in living cells (1997) (638)
Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E. (1991) (615)
Optical sectioning microscopy: cellular architecture in three dimensions. (1984) (509)
Microtubule nucleation by γ-tubulin-containing rings in the centrosome (1995) (496)
A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing (2020) (456)
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms (2020) (444)
Perturbation of Nuclear Architecture by Long-Distance Chromosome Interactions (1996) (433)
Structural studies of the scrapie prion protein by electron crystallography (2002) (421)
Structural Analysis of E. coli hsp90 Reveals Dramatic Nucleotide-Dependent Conformational Rearrangements (2006) (421)
Three-dimensional architecture of a polytene nucleus (1983) (416)
Subdiffraction-resolution fluorescence microscopy reveals a domain of the centrosome critical for pericentriolar material organization (2012) (342)
Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism (2002) (341)
Glucocorticoid Receptor Function Regulated by Coordinated Action of the Hsp90 and Hsp70 Chaperone Cycles (2014) (315)
Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase (2016) (300)
The use of a charge-coupled device for quantitative optical microscopy of biological structures. (1987) (297)
Telomeres Cluster De Novo before the Initiation of Synapsis: A Three-dimensional Spatial Analysis of Telomere Positions before and during Meiotic Prophase (1997) (297)
Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms. (1994) (296)
A molecular pore spans the double membrane of the coronavirus replication organelle (2020) (293)
Structure of the γ-tubulin ring complex: a template for microtubule nucleation (2000) (264)
A protein-folding reaction under kinetic control (1992) (263)
Determination of three-dimensional imaging properties of a light microscope system. Partial confocal behavior in epifluorescence microscopy. (1990) (248)
Conformational dynamics of the molecular chaperone Hsp90 (2011) (247)
UCSF tomography: an integrated software suite for real-time electron microscopic tomographic data collection, alignment, and reconstruction. (2007) (227)
Specific interactions of chromatin with the nuclear envelope: positional determination within the nucleus in Drosophila melanogaster. (1996) (224)
The three-dimensional architecture of chromatin in situ: electron tomography reveals fibers composed of a continuously variable zig-zag nucleosomal ribbon (1994) (223)
Fast and sensitive multi-color 3D imaging using aberration-corrected multi-focus microscopy (2012) (223)
Microtubule nucleating γTuSC assembles structures with 13-fold microtubule-like symmetry (2010) (222)
Kinetics versus thermodynamics in protein folding. (1994) (221)
Three-dimensional structural characterization of centrosomes from early Drosophila embryos (1995) (217)
Species-dependent ensembles of conserved conformational states define the Hsp90 chaperone ATPase cycle. (2008) (207)
The αlytic protease pro-region does not require a physical linkage to activate the protease domain in vivo (1989) (200)
The onset of homologous chromosome pairing during Drosophila melanogaster embryogenesis (1993) (199)
Intramolecular signaling pathways revealed by modeling anisotropic thermal diffusion. (2005) (198)
The lattice as allosteric effector: Structural studies of αβ- and γ-tubulin clarify the role of GTP in microtubule assembly (2008) (196)
Microtubule nucleation by gamma-tubulin-containing rings in the centrosome. (1995) (194)
Homologous Chromosome Pairing in Drosophila melanogaster Proceeds through Multiple Independent Initiations (1998) (191)
Interphase nuclear envelope lamins form a discontinuous network that interacts with only a fraction of the chromatin in the nuclear periphery (1990) (188)
The crystal structure of the carboxy-terminal dimerization domain of htpG, the Escherichia coli Hsp90, reveals a potential substrate binding site. (2004) (185)
Automated microscopy for electron tomography. (1992) (183)
A three-dimensional approach to mitotic chromosome structure: evidence for a complex hierarchical organization (1987) (182)
Multiple chromosomal populations of topoisomerase II detected in vivo by time-lapse, three-dimensional wide-field microscopy (1993) (178)
Unfolded conformations of α-lytic protease are more stable than its native state (1998) (178)
Fast live simultaneous multiwavelength four-dimensional optical microscopy (2010) (177)
GCP5 and GCP6: Two New Members of the Human γ-Tubulin Complex (2001) (175)
fast multicolor 3 d imaging using aberration-corrected multifocus microscopy (2012) (173)
Structural Basis of Mitochondrial Receptor Binding and Constriction by DRP1 (2018) (173)
Structural studies of a membrane-bound acetylcholine receptor from Torpedo californica. (1977) (168)
Evidence for the coincident initiation of homolog pairing and synapsis during the telomere-clustering (bouquet) stage of meiotic prophase. (2000) (165)
Fully automated, sequential tilt-series acquisition with Leginon. (2009) (165)
The role of pro regions in protein folding. (1993) (164)
Sevenfold improvement of axial resolution in 3D wide-field microscopy using two objective lenses (1995) (162)
Insights into microtubule nucleation from the crystal structure of human γ-tubulin (2005) (157)
Meiotic chromosome pairing in maize is associated with a novel chromatin organization (1994) (153)
Multiple conformations of E. coli Hsp90 in solution: insights into the conformational dynamics of Hsp90. (2008) (152)
Structural plasticity broadens the specificity of an engineered protease (1989) (151)
I5S: wide-field light microscopy with 100-nm-scale resolution in three dimensions. (2008) (151)
Energetic landscape of α-lytic protease optimizes longevity through kinetic stability (2002) (146)
Phase‐retrieved pupil functions in wide‐field fluorescence microscopy (2004) (146)
γ-Tubulin complexes and microtubule nucleation (2001) (146)
Substrate binding drives large-scale conformational changes in the Hsp90 molecular chaperone. (2011) (146)
Assembly of a nucleus-like structure during viral replication in bacteria (2017) (145)
IVE (Image Visualization Environment): a software platform for all three-dimensional microscopy applications. (1996) (144)
Amorphous no more: subdiffraction view of the pericentriolar material architecture. (2014) (139)
Integration of small-angle X-ray scattering data into structural modeling of proteins and their assemblies. (2008) (139)
Client-loading conformation of the Hsp90 molecular chaperone revealed in the cryo-EM structure of the human Hsp90:Hop complex. (2011) (139)
Three-dimensional multiple-wavelength fluorescence microscopy for the structural analysis of biological phenomena. (1991) (134)
Analysis of prepro-alpha-lytic protease expression in Escherichia coli reveals that the pro region is required for activity (1989) (133)
Serine protease mechanism: structure of an inhibitory complex of alpha-lytic protease and a tightly bound peptide boronic acid. (1987) (130)
Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism. (2014) (128)
Direct measurement of interfacial curvature distributions in a bicontinuous block copolymer morphology. (2000) (128)
Activation of a Retroviral Membrane Fusion Protein: Soluble Receptor-induced Liposome Binding of the ALSV Envelope Glycoprotein (1997) (127)
Three-dimensional structure of basal body triplet revealed by electron cryo-tomography (2011) (123)
Doubling the lateral resolution of wide-field fluorescence microscopy using structured illumination (2000) (123)
Drosophila gastrulation: analysis of cell shape changes in living embryos by three-dimensional fluorescence microscopy. (1991) (121)
Structure of the gamma-tubulin ring complex: a template for microtubule nucleation. (2000) (120)
Author Correction: Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosome (2011) (118)
An improved strategy for automated electron microscopic tomography. (2004) (117)
Large-scale chromatin structural domains within mitotic and interphase chromosomes in vivo and in vitro (1989) (109)
Direct cell lineage analysis in Drosophila melanogaster by time-lapse, three-dimensional optical microscopy of living embryos (1989) (108)
Uncovering a region of heat shock protein 90 important for client binding in E. coli and chaperone function in yeast. (2013) (107)
Focal points for chromosome condensation and decondensation revealed by three-dimensional in vivo time-lapse microscopy (1989) (106)
Computational adaptive optics for live three-dimensional biological imaging (2001) (105)
The cancer cell map initiative: defining the hallmark networks of cancer. (2015) (105)
Chromosome elasticity and mitotic polar ejection force measured in living Drosophila embryos by four-dimensional microscopy-based motion analysis (2001) (105)
Dispersion, aberration and deconvolution in multi‐wavelength fluorescence images (1996) (104)
Protease pro region required for folding is a potent inhibitor of the mature enzyme (1992) (104)
Ring closure activates yeast γTuRC for species-specific microtubule nucleation (2014) (102)
Tilted view reconstruction in optical microscopy. Three-dimensional reconstruction of Drosophila melanogaster embryo nuclei. (1989) (101)
Influence of electron dose rate on electron counting images recorded with the K2 camera. (2013) (100)
Hsp70 Forms Antiparallel Dimers Stabilized by Post-translational Modifications to Position Clients for Transfer to Hsp90 (2015) (99)
Temporal and spatial coordination of chromosome movement, spindle formation, and nuclear envelope breakdown during prometaphase in Drosophila melanogaster embryos (1990) (99)
Intra- and Intermonomer Interactions Are Required to Synergistically Facilitate ATP Hydrolysis in Hsp90*S⃞♦ (2008) (98)
Chapter 16 Solid-State Imagers for Microscopy (1988) (98)
Mechanistic studies of Sansalvamide A-amide: an allosteric modulator of Hsp90. (2010) (97)
GCP5 and GCP6: two new members of the human gamma-tubulin complex. (2001) (97)
A bacteriophage nucleus-like compartment shields DNA from CRISPR nucleases (2019) (97)
Suite of three protein crystallography beamlines with single superconducting bend magnet as the source. (2004) (96)
Gamma-tubulin complexes and microtubule nucleation. (2001) (95)
Modeling side-chain conformation for homologous proteins using an energy-based rotamer search. (1993) (95)
Turnover of regulatory subunit of cyclic AMP-dependent protein kinase in S49 mouse lymphoma cells. Regulation by catalytic subunit and analogs of cyclic AMP. (1981) (93)
To fold or not to fold.... (1993) (93)
Three-dimensional study of cylindrical morphology in a styrene-butadiene-styrene block copolymer (1988) (92)
The structure of the gamma-tubulin small complex: implications of its architecture and flexibility for microtubule nucleation. (2008) (92)
Kinetic stability as a mechanism for protease longevity. (1999) (91)
The Collection, Processing, and Display of Digital Three-Dimensional Images of Biological Specimens (1995) (90)
Asynchronous data acquisition and on-the-fly analysis of dose fractionated cryoEM images by UCSFImage. (2015) (90)
Subangstrom crystallography reveals that short ionic hydrogen bonds, and not a His-Asp low-barrier hydrogen bond, stabilize the transition state in serine protease catalysis. (2006) (89)
A Phage Tubulin Assembles Dynamic Filaments by an Atypical Mechanism to Center Viral DNA within the Host Cell (2012) (86)
Linking regions between helices in bacteriorhodopsin revealed. (1982) (86)
A least-squares method for determining structure factors in three-dimensional tilted-view reconstructions. (1983) (86)
Deconvolution in optical microscopy (1996) (86)
Phase Behavior of Ordered Diblock Copolymer Blends: Effect of Compositional Heterogeneity (1996) (85)
Salt bridge relay triggers defective LDL receptor binding by a mutant apolipoprotein. (1994) (84)
Phase retrieval for high-numerical-aperture optical systems. (2003) (84)
Toward fully automated high-resolution electron tomography. (1996) (84)
Oestrogen receptor function at classical and alternative response elements. (2000) (84)
A simple and robust procedure for preparing graphene-oxide cryo-EM grids. (2018) (83)
Precise determination of the molecular limits of a polytene chromosome band: Regulatory sequences for the Notch gene are in the interband (1988) (82)
Crystal structure of γ-tubulin complex protein GCP4 provides insight into microtubule nucleation (2011) (82)
Condensed Mitotic Chromosome Structure at Nanometer Resolution Using PALM and EGFP- Histones (2010) (82)
AIDA: an adaptive image deconvolution algorithm with application to multi-frame and three-dimensional data. (2007) (81)
A method for integrative structure determination of protein-protein complexes (2012) (80)
Anisotropic Correction of Beam-induced Motion for Improved Single-particle Electron Cryo-microscopy (2016) (79)
Cryo automated electron tomography: Towards high‐resolution reconstructions of plastic‐embedded structures (1994) (76)
Computational method for the design of enzymes with altered substrate specificity. (1991) (75)
Time-resolved, in vivo studies of mitotic spindle formation and nuclear lamina breakdown in Drosophila early embryos. (1996) (74)
High-performance iterative electron tomography reconstruction with long-object compensation using graphics processing units (GPUs). (2010) (74)
Quantitative analysis of nucleic acids, proteins, and viruses by Raman band deconvolution. (1984) (73)
The Structure and Assembly Dynamics of Plasmid Actin AlfA Imply a Novel Mechanism of DNA Segregation (2009) (72)
Structural analysis of specificity: .alpha.-lytic protease complexes with analogs of reaction intermediates (1989) (70)
Structure determination of asymmetric membrane profiles using an iterative Fourier method. (1979) (69)
Unfolded conformations of alpha-lytic protease are more stable than its native state. (1998) (69)
Structural analysis of specificity: alpha-lytic protease complexes with analogues of reaction intermediates. (1990) (69)
Kinetic properties of the binding of alpha-lytic protease to peptide boronic acids. (1988) (68)
Enzyme specificity under dynamic control: A normal mode analysis of α-lytic protease (1999) (68)
Insights into microtubule nucleation from the crystal structure of human gamma-tubulin. (2005) (68)
On the efficiency of iterative ordered subset reconstruction algorithms for acceleration on GPUs (2010) (67)
High‐resolution wide‐field microscopy with adaptive optics for spherical aberration correction and motionless focusing (2010) (66)
High-resolution restoration of 3D structures from widefield images with extreme low signal-to-noise-ratio (2013) (65)
How Hsp90 and Cdc37 Lubricate Kinase Molecular Switches. (2017) (63)
Structure of α-lytic protease complexed with its pro region (1998) (62)
Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2 (2020) (62)
Osmolyte‐induced conformational changes in the Hsp90 molecular chaperone (2009) (62)
Microstructural Analysis of a Cubic Bicontinuous Morphology in a Neat SIS Triblock Copolymer (1997) (61)
Modelling the application of adaptive optics to wide‐field microscope live imaging (2007) (61)
Molecular Dynamics Simulations Reveal the Mechanisms of Allosteric Activation of Hsp90 by Designed Ligands (2016) (61)
Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau (2018) (60)
Solid-state imagers for microscopy. (1989) (60)
Electron energy filtering significantly improves amplitude contrast of frozen-hydrated protein at 300kV. (2006) (60)
Probing the Flexibility of Large Conformational Changes in Protein Structures through Local Perturbations (2009) (59)
The conserved arginine 380 of Hsp90 is not a catalytic residue, but stabilizes the closed conformation required for ATP hydrolysis (2012) (59)
Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands. (2015) (58)
α-Bungaratoxin structure revealed by a rapid method for averaging electron density of non-crystallographically translationally related molecules (1980) (57)
Grp94, the endoplasmic reticulum Hsp90, has a similar solution conformation to cytosolic Hsp90 in the absence of nucleotide (2009) (57)
General and robust covalently linked graphene oxide affinity grids for high-resolution cryo-EM (2019) (55)
Quantitative analysis of electrophoretograms: a mathematical approach to super-resolution. (1981) (54)
pH-dependent conformational changes in bacterial Hsp90 reveal a Grp94-like conformation at pH 6 that is highly active in suppression of citrate synthase aggregation. (2009) (54)
Molecular analysis of the gene encoding α-lytic protease: evidence for a preproenzyme (1988) (53)
Crystal structures of alpha-lytic protease complexes with irreversibly bound phosphonate esters. (1993) (53)
Clathrin light and heavy chain interface: α‐helix binding superhelix loops via critical tryptophans (2002) (53)
Manipulation, Display, and Analysis of Three-Dimensional Biological Images (1990) (52)
Spatial Organization of the Drosophila Nucleus: A Three-Dimensional Cytogenetic Study (1984) (52)
The 0.83 A resolution crystal structure of alpha-lytic protease reveals the detailed structure of the active site and identifies a source of conformational strain. (2004) (52)
Correct folding of alpha-lytic protease is required for its extracellular secretion from Escherichia coli (1992) (52)
Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1 (2017) (52)
MRC2014: Extensions to the MRC format header for electron cryo-microscopy and tomography (2015) (51)
Spindle pole body duplication in fission yeast occurs at the G1/S boundary but maturation is blocked until exit from S by an event downstream of cdc10+. (2004) (51)
The three-dimensional structure of in vitro reconstituted Xenopus laevis chromosomes by EM tomography (2007) (50)
Structural basis for broad specificity in alpha-lytic protease mutants. (1993) (49)
Energetic landscape of alpha-lytic protease optimizes longevity through kinetic stability. (2002) (49)
A bacteriophage tubulin harnesses dynamic instability to center DNA in infected cells (2014) (49)
Influenza hemagglutinin: kinetic control of protein function. (1994) (47)
Cross-monomer substrate contacts reposition the Hsp90 N-terminal domain and prime the chaperone activity. (2012) (47)
The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis (2020) (46)
CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. (2021) (45)
Pro region C-terminus:protease active site interactions are critical in catalyzing the folding of alpha-lytic protease. (1998) (44)
Conformational substates in enzyme mechanism: The 120 K structure of α‐lytic protease at 1.5 Å resolution (1997) (44)
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing (2020) (43)
A Parallel Product-Convolution approach for representing the depth varying Point Spread Functions in 3D widefield microscopy based on principal component analysis. (2010) (43)
Elucidating the mechanism of substrate recognition by the bacterial Hsp90 molecular chaperone. (2014) (43)
A novel N-terminal extension in mitochondrial TRAP1 serves as a thermal regulator of chaperone activity (2014) (42)
Comprehensive analysis of protein folding activation thermodynamics reveals a universal behavior violated by kinetically stable proteases. (2005) (42)
Self-assembling SAS-6 Multimer Is a Core Centriole Building Block* (2010) (42)
Topological Similarity of Sponge‐like Bicontinuous Morphologies Differing in Length Scale (2002) (42)
Conserved tertiary couplings stabilize elements in the PDZ fold, leading to characteristic patterns of domain conformational flexibility (2010) (41)
Viral Capsid Trafficking along Treadmilling Tubulin Filaments in Bacteria (2019) (41)
Functional linkage between the active site of alpha-lytic protease and distant regions of structure: scanning alanine mutagenesis of a surface loop affects activity and substrate specificity. (1995) (40)
The Structural Asymmetry of Mitochondrial Hsp90 (Trap1) Determines Fine Tuning of Functional Dynamics. (2018) (40)
Insights into centriole geometry revealed by cryotomography of doublet and triplet centrioles (2018) (39)
Structure of Hsp90–Hsp70–Hop–GR reveals the Hsp90 client-loading mechanism (2021) (39)
Cell-cycle regulation of formin-mediated actin cable assembly (2013) (38)
Nanofibrillar Networks in Poly(ethyl methacrylate) and Its Silica Nanocomposites (2003) (38)
Structural and mechanistic exploration of acid resistance: kinetic stability facilitates evolution of extremophilic behavior. (2007) (37)
The folding landscape of Streptomyces griseus protease B reveals the energetic costs and benefits associated with evolving kinetic stability (2004) (37)
Structure of Hsp90–p23–GR reveals the Hsp90 client-remodelling mechanism (2021) (37)
The Bacterial Actin MamK (2012) (36)
Mind the gap: micro-expansion joints drastically decrease the bending of FIB-milled cryo-lamellae. (2019) (35)
Activity-Independent Discovery of Secondary Metabolites Using Chemical Elicitation and Cheminformatic Inference. (2015) (35)
Kinetic and structural characterization of mutations of glycine 216 in alpha-lytic protease: a new target for engineering substrate specificity. (1995) (35)
Design and construction of an optimal illumination system for quantitative wide‐field multi‐dimensional microscopy (1993) (34)
PRIISM: an integrated system for display and analysis of 3-D microscope images (1992) (34)
A three-dimensional structural dissection of Drosophila polytene chromosomes (1995) (34)
How general is the nucleation–condensation mechanism? (2008) (34)
Amino and PEG-Amino Graphene Oxide Grids Enrich and Protect Samples for High-resolution Single Particle Cryo-electron Microscopy (2019) (34)
The Free Energy Profile of Tubulin Straight-Bent Conformational Changes, with Implications for Microtubule Assembly and Drug Discovery (2014) (33)
3D Nanometer-Scale Study of Coexisting Bicontinuous Morphologies in a Block Copolymer/Homopolymer Blend (2006) (33)
3D widefield microscopy with two objective lenses: experimental verification of improved axial resolution (1996) (32)
Mesophile versus thermophile: insights into the structural mechanisms of kinetic stability. (2007) (32)
Mind the gap: micro-expansion joints drastically decrease the bending of FIB-milled cryo-lamellae (2019) (32)
Bacterial tubulin TubZ-Bt transitions between a two-stranded intermediate and a four-stranded filament upon GTP hydrolysis (2014) (31)
Three-Dimensional Microscopy: Image Processing For High Resolution Subcellular Imaging (1989) (31)
Mob4 plays a role in spindle focusing in Drosophila S2 cells (2008) (31)
Effect of depth dependent spherical aberrations in 3D structured illumination microscopy. (2012) (30)
The structure and assembly mechanism of a novel three-stranded tubulin filament that centers phage DNA. (2014) (30)
Interdependent folding of the N- and C-terminal domains defines the cooperative folding of alpha-lytic protease. (2003) (30)
alpha-lytic protease precursor: characterization of a structured folding intermediate. (1999) (29)
Disabling the folding catalyst is the last critical step in α‐lytic protease folding (2004) (29)
Higher-order oligomerization of Spc110p drives γ-tubulin ring complex assembly (2016) (29)
Closed loop adaptive optics for microscopy without a wavefront sensor (2010) (28)
Studies on the phosphorylation and synthesis of type I regulatory subunit of cyclic AMP-dependent protein kinase in intact S49 mouse lymphoma cells. (1981) (28)
Architecture and Assembly of a Divergent Member of the ParM Family of Bacterial Actin-like Proteins (2011) (27)
The solution structure of the viral binding domain of Tva, the cellular receptor for subgroup A avian leukosis and sarcoma virus1 (2001) (27)
Cryo-tomography tilt-series alignment with consideration of the beam-induced sample motion (2018) (27)
Binding mode prediction for a flexible ligand in a flexible pocket using multi-conformation simulated annealing pseudo crystallographic refinement. (2001) (27)
Enzyme specificity under dynamic control II: Principal component analysis of α‐lytic protease using global and local solvent boundary conditions (2001) (27)
Enzyme specificity under dynamic control: a normal mode analysis of alpha-lytic protease. (1999) (26)
Inhibition of alpha-lytic protease by pro region C-terminal steric occlusion of the active site. (1997) (26)
Single-Particle Cryo-Electron Microscopy (Cryo-EM): Progress, Challenges, and Perspectives for Further Improvement (2014) (26)
Design of Allosteric Stimulators of the Hsp90 ATPase as New Anticancer Leads. (2017) (26)
Localization and orientation of the gamma-tubulin small complex components using protein tags as labels for single particle EM. (2009) (26)
The Seckel syndrome and centrosomal protein Ninein localizes asymmetrically to stem cell centrosomes but is not required for normal development, behavior, or DNA damage response in Drosophila (2016) (25)
Microarray-based screening of heat shock protein inhibitors. (2014) (25)
Evaluation of super-resolution performance of the K2 electron-counting camera using 2D crystals of aquaporin-0. (2015) (25)
Electron cryotomography of intact motile cilia defines the basal body to axoneme transition (2019) (24)
PRISM: topologically constrained phased refinement for macromolecular crystallography. (1993) (24)
Architecture-induced phase immiscibility in a diblock/multiblock copolymer blend (1996) (24)
The Bacterial Actin MamK INVITROASSEMBLYBEHAVIORANDFILAMENTARCHITECTURE (2013) (24)
Unfolding Simulations Reveal the Mechanism of Extreme Unfolding Cooperativity in the Kinetically Stable α-Lytic Protease (2010) (24)
Automated data collection for electron microscopic tomography. (2010) (23)
Structure of alpha-lytic protease complexed with its pro region. (1998) (22)
Electron cryo-tomography provides insight into procentriole architecture and assembly mechanism (2018) (22)
Interaction of CK1δ with γTuSC ensures proper microtubule assembly and spindle positioning (2015) (22)
A novel 3D wavelet‐based filter for visualizing features in noisy biological data (2005) (22)
Internal Structure and Preferential Protein Binding of Colloidal Aggregates. (2017) (21)
Consideration of sample motion in cryo-tomography based on alignment residual interpolation. (2019) (21)
Relationship between enzyme specificity and the backbone dynamics of free and inhibited alpha-lytic protease. (1998) (21)
PRISM : automated crystallographic phase refinement by iterative skeletonization (1993) (21)
Sparse labeling of proteins: structural characterization from long range constraints. (2014) (21)
Chromosome structure inside the nucleus. (1993) (20)
Free energy calculations on binding and catalysis by α‐lytic protease: The role of substrate size in the P1 pocket (1991) (19)
Three‐dimensional microscopy in thick biological samples: A fresh approach for adjusting focus and correcting spherical aberration (1997) (19)
Crystallization and preliminary X-ray diffraction studies on the amino-terminal (receptor-binding) domain of human apolipoprotein E3 from serum very low density lipoproteins. (1988) (19)
Uniqueness and the ab initio phase problem in macromolecular crystallography. (1993) (19)
Interphase Composition Profile in SB/SBS Block Copolymers, Measured with Electron Microscopy, and Microstructural Implications (1988) (19)
Hsp70 chaperone blocks α-synuclein oligomer formation via a novel engagement mechanism (2020) (19)
Mechanism of image formation for thick biological specimens: exit wavefront reconstruction and electron energy‐loss spectroscopic imaging (1995) (19)
Mutational remodeling of enzyme specificity. (1991) (18)
Practical considerations for using K3 cameras in CDS mode for high-resolution and high-throughput single particle cryo-EM. (2021) (17)
XMAP215 and γ-tubulin additively promote microtubule nucleation in purified solutions (2020) (17)
Two energetically disparate folding pathways of α-lytic protease share a single transition state (2000) (17)
Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions (2019) (17)
Automated acquisition of electron microscopic random conical tilt sets. (2007) (17)
The pro region N-terminal domain provides specific interactions required for catalysis of alpha-lytic protease folding. (2002) (17)
Solution of Toeplitz systems for the restoration of 3-D optical-sectioning microscopy data (1990) (17)
Disabling the folding catalyst is the last critical step in alpha-lytic protease folding. (2004) (16)
Synthesis of Functionalized 2-(4-Hydroxyphenyl)-3-methylbenzofuran Allosteric Modulators of Hsp90 Activity (2016) (16)
A distributed multi-GPU system for high speed electron microscopic tomographic reconstruction. (2011) (16)
A small molecule that preferentially binds the closed conformation of Hsp90. (2011) (15)
Structure of γ-tubulin small complex based on a cryo-EM map, chemical cross-links, and a remotely related structure. (2016) (15)
Increased depth of field and stereo pairs of fluorescence micrographs via inverse filtering and maximum‐likelihood estimation (1991) (15)
Practical considerations for using K3 cameras in CDS mode for high-resolution and high-throughput single particle cryo-EM (2020) (15)
The folding landscape of an α‐lytic protease variant reveals the role of a conserved β‐hairpin in the development of kinetic stability (2005) (15)
NMR characterization of HtpG, the E. coli Hsp90, using sparse labeling with 13C-methyl alanine (2017) (14)
AreTomo: An integrated software package for automated marker-free, motion-corrected cryo-electron tomographic alignment and reconstruction (2022) (14)
A High-Speed Electron-Counting Direct Detection Camera for TEM (2011) (14)
Three-Dimensional Analysis of Biological Specimens Utilizing Image Processing Techniques (1980) (14)
Dual-axis target mapping and automated sequential acquisition of dual-axis EM tomographic data. (2009) (13)
CM1-driven assembly and activation of yeast γ-tubulin small complex underlies microtubule nucleation (2020) (13)
GR chaperone cycle mechanism revealed by cryo-EM: reactivation of GR by the GR:Hsp90:p23 client-maturation complex (2020) (13)
Practical image restoration of thick biological specimens using multiple focus levels in transmission electron microscopy. (1997) (13)
Calcium binding to a remote site can replace magnesium as cofactor for mitochondrial Hsp90 (TRAP1) ATPase activity (2018) (13)
Engineering substrate specificity (1991) (12)
Optimal strategies for imaging thick biological specimens: exit wavefront reconstruction and energy‐filtered imaging (1996) (12)
Author Correction: Structures of the HER2–HER3–NRG1β complex reveal a dynamic dimer interface (2021) (12)
Tunable instability mechanisms of polymer thin films by molecular self-assembly. (2006) (11)
An Improved Strategy for Generating Forces in Steered Molecular Dynamics: The Mechanical Unfolding of Titin, e2lip3 and Ubiquitin (2010) (11)
A nucleus-like compartment shields bacteriophage DNA from CRISPR-Cas and restriction nucleases (2018) (11)
A novel conformation of E. coli Hsp90 in solution: insights into the conformational dynamics of Hsp90 (2008) (11)
Three-dimensional light microscopy of diploid Drosophila chromosomes. (1988) (11)
From Micelles to Randomly Connected, Bilayered Membranes in Dilute Block Copolymer Blends (1997) (10)
Cryo-EM reveals the dynamic interplay between mitochondrial Hsp90 and SdhB folding intermediates (2020) (10)
The folding landscape of an alpha-lytic protease variant reveals the role of a conserved beta-hairpin in the development of kinetic stability. (2005) (10)
Centriole Duplication: Centrin in on Answers? (2002) (10)
The centrosomin CM2 domain is a multi-functional binding domain with distinct cell cycle roles (2017) (10)
An extended view of nuclear lamin structure, function, and dynamics. (1992) (9)
Molecular analysis of the gene encoding alpha-lytic protease: evidence for a preproenzyme. (1988) (9)
Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1 (2020) (9)
GR chaperone cycle mechanism revealed by cryo-EM: inactivation of GR by GR:Hsp90:Hsp70:Hop client-loading complex (2020) (9)
Crystal Structures of the Common Apolipoprotein E Variants: Insights into Functional Mechanisms (1993) (9)
Interferometer-based structured-illumination microscopy utilizing complementary phase relationship through constructive and destructive image detection by two cameras (2012) (8)
Electron cryo-tomography structure of axonemal doublet microtubule from Tetrahymena thermophila (2021) (8)
Analysis of Three-Dimensional Image Data: Display and Feature Tracking (1992) (8)
CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. (2021) (7)
Entropy-regularized deconvolution of cellular cryotransmission electron tomograms (2021) (7)
Alterations in chemical shifts and exchange broadening upon peptide boronic acid inhibitor binding to α-lytic protease (1997) (7)
Two energetically disparate folding pathways of alpha-lytic protease share a single transition state. (2000) (7)
Functional modulation of a protein folding landscape via side-chain distortion (2012) (7)
PRISM: application to the solution of two protein structures. (1993) (7)
Identification of new, well-populated amino-acid sidechain rotamers involving hydroxyl-hydrogen atoms and sulfhydryl-hydrogen atoms (2008) (7)
Performance Evaluation of a Transmission Scintillator-Based Lens-Coupled 4K CCD Camera for Use in Low-Dose Electron Cryo-Tomography (2004) (6)
Three-dimensional organization of chromosomes studied by in-situ hybridization and optical-sectioning microscopy (1990) (6)
Microtubules form by progressively faster tubulin accretion, not by nucleation-elongation (2019) (6)
Tilted view reconstruction in optical microscopy (2005) (6)
Modulation of mitochondrial Hsp90 (TRAP1) ATPase activity by calcium and magnesium (2018) (5)
The ϕPA3 phage nucleus is enclosed by a self-assembling 2D crystalline lattice (2022) (5)
Fluorescence microscopy without resolution limit (2004) (5)
Structures of the HER2–HER3–NRG1β complex reveal a dynamic dimer interface (2021) (5)
Cryo-EM analysis of human mitochondrial Hsp90 in multiple tetrameric states (2020) (5)
Proteomic analysis of microtubule inner proteins (MIPs) in Rib72 null Tetrahymena cells reveals functional MIPs (2020) (5)
Mob 4 plays a role in spindle focusing in Drosophila S 2 cells (4)
Applying adaptive optics to three-dimensional wide-field microscopy (2008) (4)
In situ cryo-electron tomography reveals the asymmetric architecture of mammalian sperm axonemes (2022) (4)
Phase retrieval of widefield microscopy point spread functions (2001) (4)
Atomic structure of Hsp90:Cdc37:Cdk4 reveals Hsp90 regulates kinase via dramatic unfolding (2016) (4)
The interplay between Bag-1, Hsp70, and Hsp90 reveals that inhibiting Hsp70 rebinding is essential for Glucocorticoid Receptor activity (2020) (4)
Editorial, Electron Tomography Workshop (1997) (3)
Reply to Letter to the Editor (2007) (3)
Three-Dimensional reconstruction of the synaptonemal complex from high-pressure frozen maize meiocytes using IVEM Tomography (1994) (3)
Functional analysis of beta-secretase using mutagenesis and structural homology modeling (2000) (3)
A family of novel immune systems targets early infection of nucleus-forming jumbo phages (2022) (3)
Assessment of the role of computations in structural biology. (2003) (3)
Three-dimensional organization of chromatin fibers in situ examined by EM tomography (1992) (3)
The Atomic Structure of the Microtubule-Nucleating γ-Tubulin Small Complex and its Implications for Regulation (2018) (3)
Structure and Action of Molecular Chaperones: Machines that Assist Protein Folding in the Cell (2016) (3)
Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt (2022) (3)
Structure and action of molecular chaperones (2016) (3)
K3 - A First Look at The New Direct Electron Detection Camera from Gatan Company (2018) (3)
Approaches for High Resolution Cryo-Electron Tomography of Biological Specimens (1997) (2)
Adaptive optics in wide-field microscopy (2011) (2)
De novo protein identification in mammalian sperm using high-resolution in situ cryo-electron tomography (2022) (2)
Application of phase-retrieved pupil functions in wide-field fluorescence microscopy (2002) (2)
Optical Sectioning Microscopy: Cellular Architecture in Three Dimensions (1984) (2)
Three-dimensional fluorescence microscopy for the analysis of spatial arrangement of chromosomes (1991) (2)
Crystal Structure of gamma-tubulin bound to GTP (2005) (2)
Mechanistic Origins of Dynamic Instability in Filaments from the Phage Tubulin, PhuZ (2018) (2)
Structural Basis of Mitochondrial Receptor Binding and GTP-Driven Conformational Constriction by Dynamin-Related Protein 1 (2017) (2)
MULTIPLE CONFORMATION STRUCTURE OF ALPHA-LYTIC PROTEASE AT 120 K (1997) (2)
Structural basis of mitochondrial receptor binding and constriction by DRP1 (2018) (2)
Full-length human mitochondrial Hsp90 (TRAP1) with ADP-BeF3 (2020) (2)
Motion estimation and visualization for four-dimensional optical microscopy (1994) (2)
Implementing Direct Electron Detection Camera K2 and Dose Fractionation for Near Atomic Resolution Single Particle CryoEM (2013) (2)
MICROSCOPY: Cellular Architecture in Three Dimensions (1984) (2)
Protein Expression and Purification of the Hsp90-Cdc37-Cdk4 Kinase Complex from Saccharomyces cerevisiae. (2017) (2)
Use of surface affinity enrichment and cryo-embedding to prepare in vitro reconstituted mitotic chromosomes for EM tomography. (2005) (2)
Hsp90 provides a platform for kinase dephosphorylation by PP5 (2022) (2)
Reconstitution of centrosome microtubule nucleation in Drosophila. (2001) (2)
α-Lytic Protease (2013) (1)
Microtubules form by progressively faster tubulin accretion, not by nucleation–elongation (2021) (1)
Electron tomography of microstructural elements in strongly segregated block copolymers (1993) (1)
Image Information Transfer Through a Post-Column Energy Filter with Detection by a Lens-Coupled Transmission-Scintillator CCD Camera (2008) (1)
Spc110 N-Terminal Domains Act Independently to Mediate Stable γ-Tubulin Small Complex Binding and γ-Tubulin Ring Complex Assembly (2018) (1)
Crystal structure of mitochondrial Hsp90 (TRAP1) NTD-Middle domain dimer with AMPPNP (2014) (1)
HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH 4-HYDROXYTAMOXIFEN (1999) (1)
Quantitative analysis of chromosome motion in Drosophila melanogaster (1995) (1)
Crystal structure of mitochondrial Hsp90 (TRAP1) with AMPPNP (2014) (1)
Automatic Multiple Tilt Series Acquisition in Leginon (2006) (1)
Kinase Regulation Through Dramatic Unfolding, as Told by Hsp90:Cdc37:Cdk4 Atomic Cryoem Structure (2017) (1)
Spatial arrangement of homologous chromosomes during anaphase in early embryos of Drosophila melanogaster studied by three-dimensional fluorescence microscopy (1997) (1)
Transmission Electron Microtomography (TEMT) of Nanostructured Polymers under Dynamically Evolving Conditions (2006) (1)
Sub-100nm Axial Resolution in 3D Widefield Optical Microscopy Using Two Opposing Objective Lenses (1997) (1)
Automated data collection for electron tomography (1992) (1)
A simple and robust procedure for preparing graphene-oxide cryo-EM grids (2018) (1)
Bacterial extracellular secretion: Transport of α-lytic protease across the outer membrane of Escherichia coli (1996) (1)
Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the Glucocorticoid Receptor (2023) (1)
Crystal structure of mitochondrial Hsp90 (TRAP1) with ATP in absence of Mg, fully hydrolyzed (2017) (1)
New Insights Into the Three-Dimensional Structure of the Nucleus and Chromosomes (1997) (1)
Automated Acquisition of Tomographic and Random Conical Tilt Series and Real-time Reconstruction Using UCSF Tomography (2006) (1)
Author Correction: Structures of the HER2–HER3–NRG1β complex reveal a dynamic dimer interface (2022) (1)
Author Correction: Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosome (2020) (1)
Connectivity and the phase problem in macromolecular crystallography (1993) (1)
Structures of the active HER2/HER3 receptor complex reveal dynamics at the dimerization interface induced by binding of a single ligand (2021) (1)
Insights into centriole biogenesis and evolution revealed by cryoTomography of doublet and triplet centrioles (2018) (1)
TomoAlign : cryo-tomography tilt-series alignment and tomographic reconstruction with motion compensation (2017) (0)
0.9A resolution crystal structure of alpha-lytic protease complexed with a transition state analogue, MeOSuc-Ala-Ala-Pro-Val boronic acid (2006) (0)
Structural Insights into the Regulation Mechanism of HSP90 by Co-chaperone AHA1 (2018) (0)
S09-04 OMX, a new microscope platform for increased time and spatial resolution (2009) (0)
ALPHA-LYTIC PROTEASE WITH MET 190 REPLACED BY ALA (1996) (0)
Growth factors and genetic modifiers in vascular biology and cancer Program : Developmental and Stem Cell Biology (2017) (0)
Structural studies of the scra electron crystallography (2016) (0)
Three-dimensional Optical Microscopy of Biological Specimens (1986) (0)
STRUCTURAL PLASTICITY AS A DETERMINANT OF ENZYME SPECIFICITY. CREATING BROADLY SPECIFIC PROTEASES (1990) (0)
Crystal structure of mitochondrial Hsp90 (TRAP1) with ATP in absence of Mg (2018) (0)
Crystal Structure of Alpha-Lytic Protease SB1+2 R64A/E182Q Mutant (2011) (0)
Elucidating the Mechanism of Protein Remodeling by the Hsp90 Molecular Chaperone (2011) (0)
Allosteric Modulation Synthesis of Functionalized 2-( 4-Hydroxyphenyl )-3-methylbenzo-furan Allosteric Modulators of Hsp 90 Activity (2016) (0)
GR chaperone cycle mechanism revealed by cryo-EM: the GR-maturation complex (2020) (0)
Cryo-EM structure of heavy chain mouse apoferritin (2020) (0)
Practical Considerations of Using the K3 Camera in CDS Mode for High-resolution and High-throughput Single Particle Cryo-EM (2020) (0)
Influence of allosteric Hsp90 ATPase activators on its chaperoning activity (2016) (0)
Thermoplasma acidophilum 20S proteasome (2015) (0)
Serial Acquisition of Dual Axis EM Tomographic Data (2008) (0)
Crystal structure of human gamma-tubulin bound to GTPgammaS (2005) (0)
Structure of Centrosomes and Chromosomes Through IVEM Tomography (1997) (0)
Crystal Structure of Full-length HtpG, the Escherichia coli Hsp90, Bound to ADP (2006) (0)
Dynamic Behavior and Three-Dimensional Shape of Nanoscale Inclusions Embedded in a Crystalline Matrix (2005) (0)
High resolution IVEM tomography of biological specimens (1997) (0)
Graphene-Oxide Substrate for High-Resolution Single Particle Cryo-EM (2018) (0)
Structural features of mTORC2 that control substrate-specific activities (2022) (0)
Tetrameric ring structure of 201phi2-1p060 from Pseudomonas phage 201phi2-1 (2014) (0)
Structure of mitochondrial Hsp90 (TRAP1) with ADP-ALF4- (2014) (0)
Imagerie adaptative informatisee (1999) (0)
Centriole Duplication: Centrin in on Answers? Dispatch (2002) (0)
PRO REGION OF ALPHA-LYTIC PROTEASE (1999) (0)
Engineered disulfide cross-linked closed conformation of the Yeast gamma-TuRC(SS) (2021) (0)
The (a) probability distribution and (b) free energy profile for the laterally-paired tubulins. (2014) (0)
Structural Insights into Hsp90 Function (2016) (0)
Full-length human mitochondrial Hsp90 (TRAP1) SpyCatcher/SpyTag-SdhB heterodimer in the presence of AMP-PNP (2021) (0)
Improved Analysis of Cross-Linking Mass Spectrometry Data with Kojak 2.0, Advanced by Integration into the Trans-Proteomic Pipeline. (2023) (0)
Chromosome structure and dynamics as revealed by 3-D and 4-D imaging (1991) (0)
Human Estrogen Receptor alpha Ligand-binding Domain in Complex with (R,R)-5,11-cis-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol and a Glucocorticoid Receptor Interacting Protein 1 NR box II Peptide (2002) (0)
Lothar Schermelleh Structured Illumination Microscopy Subdiffraction Multicolor Imaging of the Nuclear Periphery with 3 D (2012) (0)
Structure of the phage tubulin PhuZ-GDP (2012) (0)
SUPPLEMENTAL METHODS : IMAGE PROCESSING ALGORITHM STEP I – Image Deblurring via 3 D Deconvolution (2013) (0)
Crystal Structure of the Middle Domain of HtpG, the E. coli Hsp90 (2006) (0)
ALPHA-LYTIC PROTEASE WITH MET 190 REPLACED BY ALA AND GLY 216 REPLACED BY ALA COMPLEX WITH METHOXYSUCCINYL-ALA-ALA-PRO-PHENYLALANINE BORONIC ACID (1996) (0)
Synthesis and characterization of Hsp90 allosteric activators (2016) (0)
Structure and function relationships—The diploid nucleus of Drosophila (1989) (0)
Cryo-EM structures of the near full-length HER2/HER3 heterodimer reveal a novel allosteric mechanism of activation (2022) (0)
Structure of Hsp90–Hsp70–Hop–GR reveals the Hsp90 client-loading mechanism (2021) (0)
Cryo-EM structure of gamma-TuSC oligomers in a closed conformation (2016) (0)
ALPHA-LYTIC PROTEASE WITH MET 190 REPLACED BY ALA AND GLY 216 REPLACED BY ALA (1996) (0)
A bacteriophage nucleus-like compartment shields DNA from CRISPR nucleases (2019) (0)
Xrcc4-Spc110p(164-207) fusion (2021) (0)
Lothar Schermelleh , Microscopy Periphery with 3 D Structured Illumination Subdiffraction Multicolor Imaging of the Nuclear (2008) (0)
Conformational Dynamics, Structure & Substrate Protein Interactions of Hsp90 Chaperones (2012) (0)
Structure of the phage tubulin PhuZ(SeMet)-GDP (2012) (0)
T181A mutant of alpha-Lytic Protease (2012) (0)
NMR Solution Structure of sTva47, the Viral-Binding Domain of Tva (2001) (0)
Tetrameric human mitochondrial Hsp90 (TRAP1) in the presence of AMP-PNP (2021) (0)
Cryo-EM Reveals the Dynamic Interplay between Mitochondrial Hsp90 and Folding Intermediates of its SdhB Client Protein (2020) (0)
Frontispiece: Design of Allosteric Stimulators of the Hsp90 ATPase as New Anticancer Leads (2017) (0)
The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis (2020) (0)
NMR characterization of HtpG, the E. coli Hsp90, using sparse labeling with 13C-methyl alanine (2017) (0)
Structural Basis of Mitochondrial Receptor Binding and Constriction by Dynamin-Related Protein 1 (2018) (0)
Solution of the protein structure prediction problem at last: crucial innovations and next frontiers. (2022) (0)
Zebrafish TRAP1 bound to AMPPNP and calcium in the asymmetric closed state (2018) (0)
Transmission Electron Microtomography (TEMT) of Nanostructured Polymers and Polymer Nanocomposites (2005) (0)
Abstract OR-16: High Resolution Cryo-Electron Microscopy and New Direct Electron Detector from Gatan - K3 (2019) (0)
A Genetic Screen That Targets Specifically the Folding Transition State of Alpha-Lytic Protease (1999) (0)
Crystal Structure of Nocardiopsis Protease (NAPase) (2007) (0)
Image Information transfer through a post-column energy filter detected by a lens-coupled CCD camera (2008) (0)
ALPHA-LYTIC PROTEASE AT 120 K (SINGLE STRUCTURE MODEL) (1997) (0)
Crystal Structure of the N-terminal Domain of HtpG, the Escherichia coli Hsp90, Bound to ADP (2006) (0)
Next-generation interaction proteomics for quantitative Jumbophage-bacteria interaction mapping (2023) (0)
Apo full-length Hsc82 in complex with Aha1 (2021) (0)
The interface of clathrin heavy and light chain contact (2002) (0)
Full-length Hsc82 bound to AMPPNP (2021) (0)
Atomic cryoEM structure of Hsp90-Cdc37-Cdk4 complex (2016) (0)
The Onset of Homologous Chromosome Pairing (2002) (0)
Automatic tracing of ultra-volumes of neuronal images (2017) (0)
CRYSTAL STRUCTURE OF WILD-TYPE ALPHA-LYTIC PROTEASE AT 1.6 A, PH 5.14 (1999) (0)
Image reconstruction using a focus series on thick biological specimens: TEM CTF correction (1993) (0)
Crystal structure of the carboxy-terminal domain of htpG, the E. coli Hsp90 (2004) (0)
Transmission electron microtomography of multicomponent block copolymer systems (2007) (0)
Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau (2018) (0)
Heterodimeric SpyCatcher/SpyTag-fused zebrafish TRAP1 in ATP/ADP-hybrid state (2017) (0)
Front Cover: Macromol. Rapid Commun. 17/2006 (2005) (0)
0.83A resolution crystal structure of alpha-lytic protease at pH 8 (2004) (0)
Repack mutant (T181I, W199L, Q210I) of alpha-Lytic Protease (2012) (0)
Approaches to Macromolecular and Supramolecular Structure Determination (1981) (0)
Effect of monomer sequencing on the phase behavior of novel block copolymer/homopolymer blends (1996) (0)
Structure of Hsp90-p23-GR reveals the Hsp90 client-maturation mechanism (2022) (0)
Open conformation of the Yeast wild-type gamma-TuRC (2021) (0)
ALPHA-LYTIC PROTEASE COMPLEXED WITH PRO REGION (1999) (0)
Human Estrogen Receptor beta Ligand-binding Domain in Complex with (R,R)-5,11-cis-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol (2002) (0)
STRUCTURAL BASIS FOR ALTERED FUNCTION IN THE COMMON MUTANTS OF HUMAN APOLIPOPROTEIN-E (1992) (0)
0.82A resolution crystal structure of alpha-lytic protease at pH 5 (2006) (0)
Crystal Structure of full-length HTPG, the Escherichia coli HSP90 (2006) (0)
This paper was presented at the National Academy of Sciences colloquium ''Proteolytic Processing and Physiological Regulation,'' held February 20-21, 1999, at the Arnold and Mabel Beckman Center in Irvine, CA. (1999) (0)
GR chaperone cycle mechanism revealed by cryo-EM: the GR-loading complex (2020) (0)
Asymmetric hydrolysis state of Hsc82 in complex with Aha1 bound with ADP and ATPgammaS (2021) (0)
Paper of the year draft (2022) (0)
Closed conformation of the Yeast wild-type gamma-TuRC (0)
ALPHA-LYTIC PROTEASE COMPLEXED WITH C-TERMINAL TRUNCATED PRO REGION (1999) (0)
Allosteric modulators of Hsp90: design, synthesis and activity evaluation (2016) (0)
Embryonic lineage analysis using three-dimensional, time-lapse in-vivo fluorescent microscopy (1990) (0)
The role of I ; ‘ 0 regions in protein folding (2004) (0)
Regularized Reconstruction of Nonnegative Images Degraded by a Point-spread Function with a Band-limited Transfer Function (1989) (0)
Crystal Structure of Actin-like protein Alp7A (2016) (0)
An algorithm for estimation of chromosome motion in Four-Dimensional microscopic images (1994) (0)
High resolution restoration of 3 D structures from extreme low dose widefield images (2012) (0)
Quantitative Transmission Electron Microtomography of Complex Bicontinuous Polymer Nanostructures (2000) (0)
Monomeric single-particle reconstruction of the Yeast gamma-TuSC (2021) (0)
CryoEM Reveals Multi-step Activation of γTubulin and Assemblies to Optimize Microtubule Nucleation (2019) (0)
Chromosome mechanics in vivo: quantitative analysis of nonrigid 3D chromosome motion in Drosophila embryos (1996) (0)
ALPHA-LYTIC PROTEASE WITH MET 190 REPLACED BY ALA COMPLEX WITH METHOXYSUCCINYL-ALA-ALA-PRO-PHENYLALANINE BORONIC ACID (1996) (0)
Crystal Structure of Alpha-Lytic Protease SB2+3 E8A/R105S Mutant (2011) (0)
Five-Dimensional Microscopy using Widefield-Deconvolution: Practical Considerations and Biological Applications (1996) (0)
Running title : Electron Cryo-Tomography of Procentriole 1 2 3 4 5 6 7 Electron Cryo-Tomography Provides Insight into Procentriole 8 Architecture and Assembly Mechanism 9 10 (0)
Software And Hardware For 3-D Gray Level Image Analysis And Quantization (1989) (0)
Phase Behavior of Complex Diblock Copolymer Blends: A Transmission Electron Microscopy Study (1997) (0)
Structure of Hsp90–p23–GR reveals the Hsp90 client-remodelling mechanism (2021) (0)
Determination of three-dimensional imaging properties (2005) (0)
PNAS Plus Significance Statements (2013) (0)
Benzofuran Derivatives Activators of the Chaperone Protein Hsp90: Synthesis, Interaction Studies and Biological Effects (2016) (0)
Influenza hemagglutinin: kinetic control of protein function In response to decreased pH, influenza hemagglutinin changes to a more stable conformation. Such changes, which can be controlled thermodynamically or kinetically, are the method by which many biological 'switches' are thrown. (1994) (0)
Helical Model of TubZ-Bt four-stranded filament (2014) (0)
Crystal Structure of Thermobifida fusca Protease A (TFPA) (2007) (0)
Transmission Electron Microtomography of Gyroid-Forming Diblock Copolymer Blends (2004) (0)
HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH DIETHYLSTILBESTROL AND A GLUCOCORTICOID RECEPTOR INTERACTING PROTEIN 1 NR BOX II PEPTIDE (1999) (0)
Estimation and analysis of 3-D chromosome motion (1995) (0)
Crystal structure of human gamma-tubulin bound to GDP (2008) (0)

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