David A. Greenberg
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Biology
David A. Greenberg's Degrees
- Doctorate Medicine Stanford University
Why Is David A. Greenberg Influential?
(Suggest an Edit or Addition)David A. Greenberg's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Evidence for a susceptibility gene for autism on chromosome 2 and for genetic heterogeneity. (2001) (340)
- Association between a GABRB3 polymorphism and autism (2002) (325)
- Juvenile myoclonic epilepsy (JME) may be linked to the BF and HLA loci on human chromosome 6. (1988) (279)
- NOS1AP Is a Genetic Modifier of the Long-QT Syndrome (2009) (260)
- Linkage analysis of "necessary" disease loci versus "susceptibility" loci. (1993) (222)
- A C/T single-nucleotide polymorphism in the region of the CD40 gene is associated with Graves' disease. (2002) (219)
- Common and unique susceptibility loci in Graves and Hashimoto diseases: results of whole-genome screening in a data set of 102 multiplex families. (2003) (213)
- The power to detect linkage in complex disease by means of simple LOD-score analyses. (1998) (205)
- HLA associations reveal genetic heterogeneity in psoriatic arthritis and in the psoriasis phenotype. (2012) (196)
- Localization of idiopathic generalized epilepsy on chromosome 6p in families of juvenile myoclonic epilepsy patients (1991) (194)
- Centrotemporal sharp wave EEG trait in rolandic epilepsy maps to Elongator Protein Complex 4 (ELP4) (2009) (190)
- Mapping the major susceptibility loci for familial Graves' and Hashimoto's diseases: evidence for genetic heterogeneity and gene interactions. (1999) (186)
- Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease (2003) (184)
- BRD2 (RING3) is a probable major susceptibility gene for common juvenile myoclonic epilepsy. (2003) (176)
- Thyroglobulin is a thyroid specific gene for the familial autoimmune thyroid diseases. (2002) (167)
- CTLA-4 and not CD28 is a susceptibility gene for thyroid autoantibody production. (2001) (153)
- Evidence for association of polycystic ovary syndrome in caucasian women with a marker at the insulin receptor gene locus. (2001) (153)
- Double bromodomain‐containing gene Brd2 is essential for embryonic development in mouse (2009) (145)
- Genome scan of idiopathic generalized epilepsy: Evidence for major susceptibility gene and modifying genes influencing the seizure type (2001) (143)
- Genetics of autoimmune thyroid disease: lack of evidence for linkage to HLA within families. (1992) (139)
- Direct power comparisons between simple LOD scores and NPL scores for linkage analysis in complex diseases. (1999) (139)
- Arginine at position 74 of the HLA-DR β1 chain is associated with Graves' disease (2004) (138)
- Magnitude of type I error when single-locus linkage analysis is maximized over models: a simulation study. (1997) (131)
- Reproducibility and complications in gene searches: linkage on chromosome 6, heterogeneity, association, and maternal inheritance in juvenile myoclonic epilepsy. (2000) (128)
- Linkage analysis of candidate genes in autoimmune thyroid disease. II. Selected gender-related genes and the X-chromosome. International Consortium for the Genetics of Autoimmune Thyroid Disease. (1998) (121)
- Limited genetic susceptibility to severe Graves' ophthalmopathy: no role for CTLA-4 but evidence for an environmental etiology. (2000) (116)
- Adequacy of single‐locus approximations for linkage analyses of oligogenic traits (1992) (114)
- Mapping of a major susceptibility locus for Graves' disease (GD-1) to chromosome 14q31. (1997) (108)
- Inferring mode of inheritance by comparison of lod scores. (1989) (108)
- Sibling recurrence risk in autoimmune thyroid disease. (2003) (107)
- A C/T single nucleotide polymorphism at the tyrosine kinase domain of the insulin receptor gene is associated with polycystic ovary syndrome. (2002) (105)
- A new Graves disease-susceptibility locus maps to chromosome 20q11.2. International Consortium for the Genetics of Autoimmune Thyroid Disease. (1998) (105)
- Genetic analysis of families with autoimmune diabetes and thyroiditis: evidence for common and unique genes. (2005) (102)
- Autoimmune thyroiditis and diabetes: dissecting the joint genetic susceptibility in a large cohort of multiplex families. (2009) (98)
- Molecular amino acid signatures in the MHC class II peptide-binding pocket predispose to autoimmune thyroiditis in humans and in mice (2008) (96)
- Familial risk factors for microvascular complications and differential male-female risk in a large cohort of American families with type 1 diabetes. (2007) (94)
- Non-replication of association studies: “pseudo-failures” to replicate? (2007) (93)
- Further evidence for the increased power of LOD scores compared with nonparametric methods. (1999) (93)
- The influence of human leucocyte antigen (HLA) genes on autoimmune thyroid disease (AITD): results of studies in HLA‐DR3 positive AITD families (2002) (92)
- Excess of twins among affected sibling pairs with autism: implications for the etiology of autism. (2001) (91)
- Malic enzyme 2 may underlie susceptibility to adolescent-onset idiopathic generalized epilepsy. (2005) (86)
- Analysis of the CTLA-4, CD28, and inducible costimulator (ICOS) genes in autoimmune thyroid disease (2003) (83)
- Evidence for multiple gene loci in the expression of the common generalized epilepsies. (1992) (78)
- Analysis of HLA genes in families with autoimmune diabetes and thyroiditis. (2004) (77)
- Mapping the Gene for Juvenile Myoclonic Epilepsy (1989) (74)
- Inter- and intrafamilial heterogeneity: effective sampling strategies and comparison of analysis methods. (1992) (73)
- Autosomal Dominant Inheritance of Centrotemporal Sharp Waves in Rolandic Epilepsy Families (2007) (73)
- Possible interaction between HLA-DRbeta1 and thyroglobulin variants in Graves' disease. (2006) (72)
- Shared molecular amino acid signature in the HLA-DR peptide binding pocket predisposes to both autoimmune diabetes and thyroiditis (2010) (71)
- Linkage analysis under “random” and “genetic” reduced penetrance (1989) (70)
- Novel Variant of Thyroglobulin Promoter Triggers Thyroid Autoimmunity through an Epigenetic Interferon α-modulated Mechanism* (2011) (69)
- Determining trait locus position from multipoint analysis: Accuracy and power of three different statistics (2001) (68)
- Genome wide identification of new genes and pathways in patients with both autoimmune thyroiditis and type 1 diabetes. (2015) (65)
- The genetics of idiopathic generalized epilepsies of adolescent onset (1995) (64)
- GABAergic Neuron Deficit As An Idiopathic Generalized Epilepsy Mechanism: The Role Of BRD2 Haploinsufficiency In Juvenile Myoclonic Epilepsy (2011) (63)
- Linkage analysis of candidate genes in autoimmune thyroid disease: 1. Selected immunoregulatory genes. International Consortium for the Genetics of Autoimmune Thyroid Disease. (1998) (63)
- There is more than one way to collect data for linkage analysis. What a study of epilepsy can tell us about linkage strategy for psychiatric disease. (1992) (62)
- Evidence of a locus for schizophrenia and related disorders on the short arm of chromosome 5 in a large pedigree. (1996) (60)
- Sensitivity of lod scores to changes in diagnostic status. (1992) (57)
- A germline single nucleotide polymorphism at the intracellular domain of the human thyrotropin receptor does not have a major effect on the development of Graves' disease. (2002) (57)
- Evidence for linkage of adolescent-onset idiopathic generalized epilepsies to chromosome 8-and genetic heterogeneity. (1999) (57)
- Segregation analysis of juvenile myoclonic epilepsy (1994) (56)
- Adequacy of single-locus approximations for linkage analyses of oligogenic traits: extension to multigenerational pedigree structures. (1993) (56)
- Analysis of immune regulatory genes in familial and sporadic Graves' disease. (2004) (56)
- Evidence for recessive and against dominant inheritance at the HLA-"linked" locus in coeliac disease. (1982) (55)
- Dissecting genetic heterogeneity in autoimmune thyroid diseases by subset analysis. (2007) (52)
- 'Linkage analysis of thyroid antibody production: evidence for shared susceptibility to clinical autoimmune thyroid disease. (2008) (51)
- Blinders, phenotype, and fashionable genetic analysis: A critical examination of the current state of epilepsy genetic studies (2011) (50)
- "Susceptibility" Loci (2006) (49)
- Osteonectin/SPARC polymorphisms in Caucasian men with idiopathic osteoporosis (2008) (49)
- Linkage analysis of candidate genes in autoimmune thyroid disease. III. Detailed analysis of chromosome 14 localizes Graves' disease-1 (GD-1) close to multinodular goiter-1 (MNG-1). International Consortium for the Genetics of Autoimmune Thyroid Disease. (1998) (49)
- Fine mapping of loci linked to autoimmune thyroid disease identifies novel susceptibility genes. (2013) (47)
- Affecteds-only linkage methods are not a panacea. (1996) (46)
- Effect of Population Stratification on Case-Control Association Studies (2004) (46)
- Centralizing the non‐central chi‐square: a new method to correct for population stratification in genetic case‐control association studies (2006) (46)
- Quantification of type I error probabilities for heterogeneity LOD scores (2002) (45)
- HLODs remain powerful tools for detection of linkage in the presence of genetic heterogeneity. (2002) (44)
- Is juvenile myoclonic epilepsy an autosomal recessive disease? (1990) (41)
- Linkage analysis assuming a single‐locus mode of inheritance for traits determined by two loci: Inferring mode of inheritance and estimating penetrance (1990) (40)
- Complex inheritance and parent-of-origin effect in juvenile myoclonic epilepsy (2006) (39)
- Effect of Population Stratification on Case-Control Association Studies (2004) (37)
- Genetic association analysis: a primer on how it works, its strengths and its weaknesses. (2008) (37)
- Two locus models for gluten sensitive enteropathy: population genetic considerations. (1981) (36)
- The Chromosome 6p Epilepsy Locus: Exploring Mode of Inheritance and Heterogeneity Through Linkage Analysis (1993) (35)
- An autosomal dominant genetically heterogeneous variant of rolandic epilepsy and speech disorder (2008) (35)
- The state of the art in the genetic analysis of the epilepsies (2007) (34)
- A simple method for testing two-locus models of inheritance. (1981) (34)
- Possible Association of Juvenile Myoclonic Epilepsy with HLA‐DRw6 (1992) (33)
- A maximum likelihood test of the two locus model for coeliac disease. (1982) (33)
- The Immunogenetics of Autoimmune Diabetes and Autoimmune Thyroid Disease (1997) (32)
- The emperor's new methods. (2003) (31)
- Using lod-score differences to determine mode of inheritance: a simple, robust method even in the presence of heterogeneity and reduced penetrance. (1994) (30)
- Effect of heterogeneity and assumed mode of inheritance on lod scores. (1992) (30)
- Dissecting the Genetic Susceptibility to Graves’ Disease in a Cohort of Patients of Italian Origin (2016) (29)
- The effects of conditioning on probands to correct for multiple ascertainment. (1984) (29)
- Effect of misspecification of gene frequency on the two-point LOD score (2001) (28)
- Association of HLA class II alleles in patients with juvenile myoclonic epilepsy compared with patients with other forms of adolescent-onset generalized epilepsy (1996) (28)
- Is there a genetic relationship between epilepsy and birth defects? (1992) (26)
- Lack of disease associated HLA-DQ restriction fragment length polymorphisms in families with autoimmune thyroid disease. (1993) (26)
- Autoimmune thyroid disease susceptibility loci in a large Chinese family (2002) (25)
- A Unified Approach for Quantifying, Testing and Correcting Population Stratification in Case-Control Association Studies (2007) (25)
- Genetic analysis in young-age-of-onset Graves' disease reveals new susceptibility loci. (2014) (24)
- Simulated data for a complex genetic trait (Problem 2 for GAW11): How the model was developed, and why (1999) (23)
- Sub-genic intolerance, ClinVar, and the epilepsies: A whole-exome sequencing study of 29,165 individuals. (2021) (23)
- Estimation of the frequency of hexosaminidase a variant alleles in the American Jewish population. (1982) (23)
- Case-Control Association Studies in Mixed Populations: Correcting Using Genomic Control (2005) (23)
- The thyroglobulin gene as the first thyroid-specific susceptibility gene for autoimmune thyroid disease. (2004) (23)
- Partitioned association‐linkage test: distinguishing “necessary” from “susceptibility” loci (1996) (22)
- Evaluating Genetic Heterogeneity in Complex Disorders (2002) (22)
- Pathogenic EFHC1 mutations are tolerated in healthy individuals dependent on reported ancestry (2014) (22)
- What is the contribution of a kozak snp in the CD40 gene to graves’ disease? (2005) (21)
- Linkage analysis of two-locus diseases under single-locus and two-locus analysis models. (1992) (21)
- The effect of proband designation on segregation analysis. (1986) (21)
- The bromodomain‐containing gene BRD2 is regulated at transcription, splicing, and translation levels (2011) (21)
- Power, mode of inheritance, and type I error in LOD scores and affecteds-only methods: reply to Kruglyak. (1998) (21)
- DNA methylation of the BRD2 promoter is associated with juvenile myoclonic epilepsy in Caucasians (2018) (21)
- Genetics of epilepsy: epilepsy research foundation workshop report. (2007) (20)
- How Can We Explain Very Low Odds Ratios in GWAS? I. Polygenic Models (2017) (20)
- Looking for epilepsy genes: clinical and molecular genetic studies. (1986) (20)
- Sex‐specific behavioral traits in the Brd2 mouse model of juvenile myoclonic epilepsy (2014) (18)
- No evidence for a major susceptibility locus for juvenile myoclonic epilepsy on chromosome 15q. (2000) (18)
- Novel loci interacting epistatically with bone morphogenetic protein receptor 2 cause familial pulmonary arterial hypertension. (2010) (17)
- Construction of the model for the Genetic Analysis Workshop 14 simulated data: genotype-phenotype relationships, gene interaction, linkage, association, disequilibrium, and ascertainment effects for a complex phenotype (2005) (17)
- A NOVEL VARIANT OF THE THYROGLOBULIN PROMOTER TRIGGERS THYROID AUTOIMMUNITY THROUGH AN EPIGENETIC INTERFERON ALPHA-MODULATED MECHANISM (2011) (16)
- Methods for Assessing Familial Aggregation: Family History Measures and Confounding in the Standard Cohort, Reconstructed Cohort and Case-Control Designs (2009) (16)
- Trait impulsivity in Juvenile Myoclonic Epilepsy (2020) (15)
- Evaluating candidate genes in common epilepsies and the nature of evidence (2008) (14)
- The genetics of the autoimmune thyroid diseases. (2003) (13)
- Biologic markers, genetics, and Alzheimer's disease. (1988) (12)
- HLA class I and II alleles are associated with microvascular complications of type 1 diabetes. (2013) (12)
- Simulation studies of segregation analysis: application to two-locus models. (1984) (12)
- Genetic and environmental influences on the overlap between premorbid IQ, premorbid social adjustment and schizophrenia: A population-based twin and sibling study (2008) (12)
- Comparative Informativeness for Linkage of Multiple SNPs and Single Microsatellites (2005) (12)
- Phenocopies versus genetic heterogeneity: can we use phenocopy frequencies in linkage analysis to compensate for heterogeneity? (1996) (12)
- Comparison of fetal and maternal chromosome polymorphisms: Applications in prenatal diagnosis (1982) (12)
- How should we be searching for genes for common epilepsy? A critique and a prescription (2012) (11)
- Sex-specific disease modifiers in juvenile myoclonic epilepsy (2022) (11)
- Multipoint lods provide reliable linkage evidence despite unknown limiting distribution: type I error probabilities decrease with sample size for multipoint lods and mods (2008) (11)
- Finding disease genes: a fast and flexible approach for analyzing high-throughput data (2011) (11)
- Sa.26. Heterogeneity of the Psoriasis Phenotype Revealed by HLA Class I Haplotype Associations in Psoriatic Arthritis and Psoriasis (2008) (10)
- Summary of analyses of problem 2 simulated data for GAW11 (1999) (10)
- Using Linkage Analysis to Detect Gene-Gene Interactions. 2. Improved Reliability and Extension to More-Complex Models (2016) (9)
- Linkage Analysis of Genomic Regions Contributing to the Expression of Type 1 Diabetes Microvascular Complications and Interaction with HLA (2015) (9)
- Simulation study comparing interval estimates for the recombination fraction (1995) (8)
- Multiple Subsampling of Dense SNP Data Localizes Disease Genes with Increased Precision (2009) (8)
- The heterogeneity problem. I: Separating genetic from environmental forms of the same disease. (1985) (7)
- Computer Simulation Is an Undervalued Tool for Genetic Analysis: A Historical View and Presentation of SHIMSHON – A Web-Based Genetic Simulation Package (2011) (7)
- Using Linkage Analysis to Detect Gene-Gene Interaction by Stratifying Family Data on Known Disease, or Disease-Associated, Alleles (2014) (7)
- Paraoxonase genes and susceptibility to ALS (2009) (7)
- Mapping genes in juvenile myoclonic epilepsy. (1987) (7)
- Better data analysis through data exploration. (1993) (7)
- The Genetics of Febrile Seizures (2002) (7)
- Major Susceptibility Genes for Common Idiopathic Epilepsies: ELP4 in Rolandic Epilepsy and BRD2 in Juvenile Myoclonic Epilepsy (2012) (7)
- Robustness of Case-Control Studies to Population Stratification (2005) (6)
- A comparison of multiplex and simplex families with Alzheimer's disease/senile dementia of Alzheimer type within a well defined population (1994) (6)
- The Reliability of Haplotyping Inference in Nuclear Families: Misassignment Rates for SNPs and Microsatellites (2004) (6)
- Identifying genetic risk loci for diabetic complications and showing evidence for heterogeneity of type 1 diabetes based on complications risk (2018) (6)
- Next-generation linkage and association methods applied to hypertension: a multifaceted approach to the analysis of sequence data (2014) (6)
- Replication, reanalysis, and gene expression: ME2 and genetic generalized epilepsy (2019) (6)
- Developmental decrease in parvalbumin‐positive neurons precedes increase in flurothyl‐induced seizure susceptibility in the Brd2+/− mouse model of juvenile myoclonic epilepsy (2020) (6)
- Brd2 haploinsufficiency extends lifespan and healthspan in C57B6/J mice (2020) (5)
- Using Lod Scores to Detect Sex Differences in Male-Female Recombination Fractions (2004) (5)
- Response to Visscher (2002) (5)
- Genetic epidemiology and the search for epilepsy genes. (1999) (5)
- Remind me again what disease we are studying? A population genetics, genetic analysis, and real data perspective on why progress on identifying genetic influences on common epilepsies has been so slow. (2014) (5)
- Genetic Analysis Workshop 14: Introduction to Workshop Summaries (2005) (5)
- The Rise and Fall and Rise of Linkage Analysis as a Technique for Finding and Characterizing Inherited Influences on Disease Expression. (2018) (4)
- The Genetic Susceptibility to Type 1 (Insulin-Dependent) Diabetes Mellitus and the Autoimmune Thyroid Diseases (1999) (4)
- Effect of Population Stratification on (2004) (3)
- Is Juvenile Myoclonic Epilepsy Polygenic (1989) (3)
- Perspectives: Clues in Mapping Epilepsy Genes (1989) (3)
- The Essence of Linkage‐based Imprinting Detection: Comparing Power, Type 1 Error, and the Effects of Confounders in Two Different Analysis Approaches (2010) (3)
- HLA and Epilepsy (1989) (3)
- The choice of epilepsy syndromes for genetic analysis. (1991) (3)
- Investigations of a Two-Locus Model for Coeliac Disease (1981) (3)
- An Improved Delta-Centralization Method for Population Stratification (2011) (2)
- Second-order approximations of ascertainment probabilities. (1980) (2)
- Major Susceptibility Genes for Common Idiopathic Epilepsies (2012) (2)
- Reply to Farrall. LOD wars: The affected-sib-pair paradigm strikes back! (1997) (2)
- Genetic studies of typical Alzheimer's disease (1989) (2)
- Genetics of juvenile myoclonic epilepsy (2005) (2)
- Testing the simple 3‐allele model of inheritance of IDDM at the HLA‐associated locus (1986) (1)
- NOS1AP Is a Genetic Modifier of Congenital Long-QT Syndrome (2009) (1)
- Correction: Using Linkage Analysis to Detect Gene-Gene Interactions. 2. Improved Reliability and Extension to More-Complex Models (2016) (1)
- Comments on: Review and Evaluation of Methods Correcting for Population Stratification with a Focus on Underlying Statistical Principles (2008) (1)
- Sub-genic intolerance, ClinVar, and the epilepsies: A whole-exome sequencing study of 29,165 individuals. (2021) (1)
- ELP4 in rolandic epilepsy and BRD2 in juvenile myoclonic epilepsy (2010) (1)
- In Response: ME2 association analysis in adolescent‐onset genetic generalized epilepsy (2019) (1)
- The application of jackknife statistics to estimates of the recombination fraction (1993) (1)
- Subject Index Vol. 58, 2004 (2005) (0)
- Figure 6, Sagittal sections of E11.5 embryos of wild-type and mutant embryos (2012) (0)
- Figure 8, Seizure sensitivity to pentylenetetrazol in Wild-type and Brd2+/− mice (2012) (0)
- 30. Genetics of autism (2000) (0)
- Figure 7, Whole-mount in situ hybridization of wild-type and Brd2 mutant E9.5 embryos using digoxygenin-labeled Brd2 RNA probes (2012) (0)
- SLCO5A1 and synaptic assembly genes contribute to impulsivity in juvenile myoclonic epilepsy (2022) (0)
- Contents Vol. 53, 2002 (2002) (0)
- Response to comments on the paper “Blinders, phenotype, and fashionable genetic analysis: A critical examination of the current state of epilepsy genetic studies” (2011) (0)
- Contents Vol. 58, 2004 (2005) (0)
- Comments on ‘Delta-Centralization Fails to Control for Population Stratification in Genetic Association Studies’ (2010) (0)
- AUTOSOMAL DOMINANT TRANSMISSION OF CENTROTEMPORAL SPIKES IN ROLANDIC EPILEPSY FAMILIES (2006) (0)
- Genetics of juvenile myoclonic epilepsy: faulty components and faulty wiring? (2005) (0)
- INVITED EDITORIAL The Emperor's New Methods (2003) (0)
- Contributors and Participants (1982) (0)
- Figure 2, Joint Analysis of Discovery (US) and Replication (Canadian) datasets (2012) (0)
- 84: Combined linkage-methylome analysis to uncover the molecular basis of racial disparities in preterm birth (PTB) (2020) (0)
- Figure 9, Differences in density of parvalbumin-stained neurons in Brd2+/− vs WT in four brain regions: Cg1 – cingulated cortex, area 1; Prl – prelimbic cortex; IL – infralimbic cortex; DP – dorsal peduncular cortex (2012) (0)
- Subject Index Vol. 69, 2010 (2010) (0)
- The BTK Gene as Candidate Gene for Graves’ Disease (2000) (0)
- The Genetics of Common Epilepsy Disorders: Lessons Learned from the Channelopathy Era (2014) (0)
- Contents Vol. 72, 2011 (2011) (0)
- BRD2: The First Locus Discovered for a Common Epilepsy (Juvenile Myoclonic Epilepsy): What Was Right, What Was Wrong, and How Studies of IGE Make Progress (2019) (0)
- Contents Vol. 69, 2010 (2010) (0)
- Subject Index Vol. 53, 2002 (2002) (0)
- Figure 1, Pure likelihood plot of association evidence in discovery set and in joint analysis of data sets (Figure 2) (2012) (0)
- How many false positives do we get when we maximize Zmax (1996) (0)
- A linkage marker for schizophrenia and related disorders (1994) (0)
- HLA Sharing and History of Miscarriage among Women with Rheumatoid Arthritis (2006) (0)
- Contents, Vol. 43, 1993 (1993) (0)
- Subject Index, Vol. 43, 1993 (1993) (0)
- A neuroimaging correlate for a schizophrenia-related genetic marker in one pedigree (1995) (0)
- Figure 5, Photographs of wild-type (Brd2−/−, left) and Brd2−/− (right) embryos at embryonic day (E) 9.5 of gestation (2012) (0)
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