David A. Greenberg

David A. Greenberg's AcademicInfluence.com Rankings

David A. Greenberg

Biology

#14366

World Rank

#18095

Historical Rank

Genetics

#1635

World Rank

#1743

Historical Rank

biology Degrees

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Biology

David A. Greenberg's Degrees

Doctorate Medicine Stanford University

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David A. Greenberg's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Evidence for a susceptibility gene for autism on chromosome 2 and for genetic heterogeneity. (2001) (340)
Association between a GABRB3 polymorphism and autism (2002) (325)
Juvenile myoclonic epilepsy (JME) may be linked to the BF and HLA loci on human chromosome 6. (1988) (279)
NOS1AP Is a Genetic Modifier of the Long-QT Syndrome (2009) (260)
Linkage analysis of "necessary" disease loci versus "susceptibility" loci. (1993) (222)
A C/T single-nucleotide polymorphism in the region of the CD40 gene is associated with Graves' disease. (2002) (219)
Common and unique susceptibility loci in Graves and Hashimoto diseases: results of whole-genome screening in a data set of 102 multiplex families. (2003) (213)
The power to detect linkage in complex disease by means of simple LOD-score analyses. (1998) (205)
HLA associations reveal genetic heterogeneity in psoriatic arthritis and in the psoriasis phenotype. (2012) (196)
Localization of idiopathic generalized epilepsy on chromosome 6p in families of juvenile myoclonic epilepsy patients (1991) (194)
Centrotemporal sharp wave EEG trait in rolandic epilepsy maps to Elongator Protein Complex 4 (ELP4) (2009) (190)
Mapping the major susceptibility loci for familial Graves' and Hashimoto's diseases: evidence for genetic heterogeneity and gene interactions. (1999) (186)
Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease (2003) (184)
BRD2 (RING3) is a probable major susceptibility gene for common juvenile myoclonic epilepsy. (2003) (176)
Thyroglobulin is a thyroid specific gene for the familial autoimmune thyroid diseases. (2002) (167)
CTLA-4 and not CD28 is a susceptibility gene for thyroid autoantibody production. (2001) (153)
Evidence for association of polycystic ovary syndrome in caucasian women with a marker at the insulin receptor gene locus. (2001) (153)
Double bromodomain‐containing gene Brd2 is essential for embryonic development in mouse (2009) (145)
Genome scan of idiopathic generalized epilepsy: Evidence for major susceptibility gene and modifying genes influencing the seizure type (2001) (143)
Genetics of autoimmune thyroid disease: lack of evidence for linkage to HLA within families. (1992) (139)
Direct power comparisons between simple LOD scores and NPL scores for linkage analysis in complex diseases. (1999) (139)
Arginine at position 74 of the HLA-DR β1 chain is associated with Graves' disease (2004) (138)
Magnitude of type I error when single-locus linkage analysis is maximized over models: a simulation study. (1997) (131)
Reproducibility and complications in gene searches: linkage on chromosome 6, heterogeneity, association, and maternal inheritance in juvenile myoclonic epilepsy. (2000) (128)
Linkage analysis of candidate genes in autoimmune thyroid disease. II. Selected gender-related genes and the X-chromosome. International Consortium for the Genetics of Autoimmune Thyroid Disease. (1998) (121)
Limited genetic susceptibility to severe Graves' ophthalmopathy: no role for CTLA-4 but evidence for an environmental etiology. (2000) (116)
Adequacy of single‐locus approximations for linkage analyses of oligogenic traits (1992) (114)
Mapping of a major susceptibility locus for Graves' disease (GD-1) to chromosome 14q31. (1997) (108)
Inferring mode of inheritance by comparison of lod scores. (1989) (108)
Sibling recurrence risk in autoimmune thyroid disease. (2003) (107)
A C/T single nucleotide polymorphism at the tyrosine kinase domain of the insulin receptor gene is associated with polycystic ovary syndrome. (2002) (105)
A new Graves disease-susceptibility locus maps to chromosome 20q11.2. International Consortium for the Genetics of Autoimmune Thyroid Disease. (1998) (105)
Genetic analysis of families with autoimmune diabetes and thyroiditis: evidence for common and unique genes. (2005) (102)
Autoimmune thyroiditis and diabetes: dissecting the joint genetic susceptibility in a large cohort of multiplex families. (2009) (98)
Molecular amino acid signatures in the MHC class II peptide-binding pocket predispose to autoimmune thyroiditis in humans and in mice (2008) (96)
Familial risk factors for microvascular complications and differential male-female risk in a large cohort of American families with type 1 diabetes. (2007) (94)
Non-replication of association studies: “pseudo-failures” to replicate? (2007) (93)
Further evidence for the increased power of LOD scores compared with nonparametric methods. (1999) (93)
The influence of human leucocyte antigen (HLA) genes on autoimmune thyroid disease (AITD): results of studies in HLA‐DR3 positive AITD families (2002) (92)
Excess of twins among affected sibling pairs with autism: implications for the etiology of autism. (2001) (91)
Malic enzyme 2 may underlie susceptibility to adolescent-onset idiopathic generalized epilepsy. (2005) (86)
Analysis of the CTLA-4, CD28, and inducible costimulator (ICOS) genes in autoimmune thyroid disease (2003) (83)
Evidence for multiple gene loci in the expression of the common generalized epilepsies. (1992) (78)
Analysis of HLA genes in families with autoimmune diabetes and thyroiditis. (2004) (77)
Mapping the Gene for Juvenile Myoclonic Epilepsy (1989) (74)
Inter- and intrafamilial heterogeneity: effective sampling strategies and comparison of analysis methods. (1992) (73)
Autosomal Dominant Inheritance of Centrotemporal Sharp Waves in Rolandic Epilepsy Families (2007) (73)
Possible interaction between HLA-DRbeta1 and thyroglobulin variants in Graves' disease. (2006) (72)
Shared molecular amino acid signature in the HLA-DR peptide binding pocket predisposes to both autoimmune diabetes and thyroiditis (2010) (71)
Linkage analysis under “random” and “genetic” reduced penetrance (1989) (70)
Novel Variant of Thyroglobulin Promoter Triggers Thyroid Autoimmunity through an Epigenetic Interferon α-modulated Mechanism* (2011) (69)
Determining trait locus position from multipoint analysis: Accuracy and power of three different statistics (2001) (68)
Genome wide identification of new genes and pathways in patients with both autoimmune thyroiditis and type 1 diabetes. (2015) (65)
The genetics of idiopathic generalized epilepsies of adolescent onset (1995) (64)
GABAergic Neuron Deficit As An Idiopathic Generalized Epilepsy Mechanism: The Role Of BRD2 Haploinsufficiency In Juvenile Myoclonic Epilepsy (2011) (63)
Linkage analysis of candidate genes in autoimmune thyroid disease: 1. Selected immunoregulatory genes. International Consortium for the Genetics of Autoimmune Thyroid Disease. (1998) (63)
There is more than one way to collect data for linkage analysis. What a study of epilepsy can tell us about linkage strategy for psychiatric disease. (1992) (62)
Evidence of a locus for schizophrenia and related disorders on the short arm of chromosome 5 in a large pedigree. (1996) (60)
Sensitivity of lod scores to changes in diagnostic status. (1992) (57)
A germline single nucleotide polymorphism at the intracellular domain of the human thyrotropin receptor does not have a major effect on the development of Graves' disease. (2002) (57)
Evidence for linkage of adolescent-onset idiopathic generalized epilepsies to chromosome 8-and genetic heterogeneity. (1999) (57)
Segregation analysis of juvenile myoclonic epilepsy (1994) (56)
Adequacy of single-locus approximations for linkage analyses of oligogenic traits: extension to multigenerational pedigree structures. (1993) (56)
Analysis of immune regulatory genes in familial and sporadic Graves' disease. (2004) (56)
Evidence for recessive and against dominant inheritance at the HLA-"linked" locus in coeliac disease. (1982) (55)
Dissecting genetic heterogeneity in autoimmune thyroid diseases by subset analysis. (2007) (52)
'Linkage analysis of thyroid antibody production: evidence for shared susceptibility to clinical autoimmune thyroid disease. (2008) (51)
Blinders, phenotype, and fashionable genetic analysis: A critical examination of the current state of epilepsy genetic studies (2011) (50)
"Susceptibility" Loci (2006) (49)
Osteonectin/SPARC polymorphisms in Caucasian men with idiopathic osteoporosis (2008) (49)
Linkage analysis of candidate genes in autoimmune thyroid disease. III. Detailed analysis of chromosome 14 localizes Graves' disease-1 (GD-1) close to multinodular goiter-1 (MNG-1). International Consortium for the Genetics of Autoimmune Thyroid Disease. (1998) (49)
Fine mapping of loci linked to autoimmune thyroid disease identifies novel susceptibility genes. (2013) (47)
Affecteds-only linkage methods are not a panacea. (1996) (46)
Effect of Population Stratification on Case-Control Association Studies (2004) (46)
Centralizing the non‐central chi‐square: a new method to correct for population stratification in genetic case‐control association studies (2006) (46)
Quantification of type I error probabilities for heterogeneity LOD scores (2002) (45)
HLODs remain powerful tools for detection of linkage in the presence of genetic heterogeneity. (2002) (44)
Is juvenile myoclonic epilepsy an autosomal recessive disease? (1990) (41)
Linkage analysis assuming a single‐locus mode of inheritance for traits determined by two loci: Inferring mode of inheritance and estimating penetrance (1990) (40)
Complex inheritance and parent-of-origin effect in juvenile myoclonic epilepsy (2006) (39)
Effect of Population Stratification on Case-Control Association Studies (2004) (37)
Genetic association analysis: a primer on how it works, its strengths and its weaknesses. (2008) (37)
Two locus models for gluten sensitive enteropathy: population genetic considerations. (1981) (36)
The Chromosome 6p Epilepsy Locus: Exploring Mode of Inheritance and Heterogeneity Through Linkage Analysis (1993) (35)
An autosomal dominant genetically heterogeneous variant of rolandic epilepsy and speech disorder (2008) (35)
The state of the art in the genetic analysis of the epilepsies (2007) (34)
A simple method for testing two-locus models of inheritance. (1981) (34)
Possible Association of Juvenile Myoclonic Epilepsy with HLA‐DRw6 (1992) (33)
A maximum likelihood test of the two locus model for coeliac disease. (1982) (33)
The Immunogenetics of Autoimmune Diabetes and Autoimmune Thyroid Disease (1997) (32)
The emperor's new methods. (2003) (31)
Using lod-score differences to determine mode of inheritance: a simple, robust method even in the presence of heterogeneity and reduced penetrance. (1994) (30)
Effect of heterogeneity and assumed mode of inheritance on lod scores. (1992) (30)
Dissecting the Genetic Susceptibility to Graves’ Disease in a Cohort of Patients of Italian Origin (2016) (29)
The effects of conditioning on probands to correct for multiple ascertainment. (1984) (29)
Effect of misspecification of gene frequency on the two-point LOD score (2001) (28)
Association of HLA class II alleles in patients with juvenile myoclonic epilepsy compared with patients with other forms of adolescent-onset generalized epilepsy (1996) (28)
Is there a genetic relationship between epilepsy and birth defects? (1992) (26)
Lack of disease associated HLA-DQ restriction fragment length polymorphisms in families with autoimmune thyroid disease. (1993) (26)
Autoimmune thyroid disease susceptibility loci in a large Chinese family (2002) (25)
A Unified Approach for Quantifying, Testing and Correcting Population Stratification in Case-Control Association Studies (2007) (25)
Genetic analysis in young-age-of-onset Graves' disease reveals new susceptibility loci. (2014) (24)
Simulated data for a complex genetic trait (Problem 2 for GAW11): How the model was developed, and why (1999) (23)
Sub-genic intolerance, ClinVar, and the epilepsies: A whole-exome sequencing study of 29,165 individuals. (2021) (23)
Estimation of the frequency of hexosaminidase a variant alleles in the American Jewish population. (1982) (23)
Case-Control Association Studies in Mixed Populations: Correcting Using Genomic Control (2005) (23)
The thyroglobulin gene as the first thyroid-specific susceptibility gene for autoimmune thyroid disease. (2004) (23)
Partitioned association‐linkage test: distinguishing “necessary” from “susceptibility” loci (1996) (22)
Evaluating Genetic Heterogeneity in Complex Disorders (2002) (22)
Pathogenic EFHC1 mutations are tolerated in healthy individuals dependent on reported ancestry (2014) (22)
What is the contribution of a kozak snp in the CD40 gene to graves’ disease? (2005) (21)
Linkage analysis of two-locus diseases under single-locus and two-locus analysis models. (1992) (21)
The effect of proband designation on segregation analysis. (1986) (21)
The bromodomain‐containing gene BRD2 is regulated at transcription, splicing, and translation levels (2011) (21)
Power, mode of inheritance, and type I error in LOD scores and affecteds-only methods: reply to Kruglyak. (1998) (21)
DNA methylation of the BRD2 promoter is associated with juvenile myoclonic epilepsy in Caucasians (2018) (21)
Genetics of epilepsy: epilepsy research foundation workshop report. (2007) (20)
How Can We Explain Very Low Odds Ratios in GWAS? I. Polygenic Models (2017) (20)
Looking for epilepsy genes: clinical and molecular genetic studies. (1986) (20)
Sex‐specific behavioral traits in the Brd2 mouse model of juvenile myoclonic epilepsy (2014) (18)
No evidence for a major susceptibility locus for juvenile myoclonic epilepsy on chromosome 15q. (2000) (18)
Novel loci interacting epistatically with bone morphogenetic protein receptor 2 cause familial pulmonary arterial hypertension. (2010) (17)
Construction of the model for the Genetic Analysis Workshop 14 simulated data: genotype-phenotype relationships, gene interaction, linkage, association, disequilibrium, and ascertainment effects for a complex phenotype (2005) (17)
A NOVEL VARIANT OF THE THYROGLOBULIN PROMOTER TRIGGERS THYROID AUTOIMMUNITY THROUGH AN EPIGENETIC INTERFERON ALPHA-MODULATED MECHANISM (2011) (16)
Methods for Assessing Familial Aggregation: Family History Measures and Confounding in the Standard Cohort, Reconstructed Cohort and Case-Control Designs (2009) (16)
Trait impulsivity in Juvenile Myoclonic Epilepsy (2020) (15)
Evaluating candidate genes in common epilepsies and the nature of evidence (2008) (14)
The genetics of the autoimmune thyroid diseases. (2003) (13)
Biologic markers, genetics, and Alzheimer's disease. (1988) (12)
HLA class I and II alleles are associated with microvascular complications of type 1 diabetes. (2013) (12)
Simulation studies of segregation analysis: application to two-locus models. (1984) (12)
Genetic and environmental influences on the overlap between premorbid IQ, premorbid social adjustment and schizophrenia: A population-based twin and sibling study (2008) (12)
Comparative Informativeness for Linkage of Multiple SNPs and Single Microsatellites (2005) (12)
Phenocopies versus genetic heterogeneity: can we use phenocopy frequencies in linkage analysis to compensate for heterogeneity? (1996) (12)
Comparison of fetal and maternal chromosome polymorphisms: Applications in prenatal diagnosis (1982) (12)
How should we be searching for genes for common epilepsy? A critique and a prescription (2012) (11)
Sex-specific disease modifiers in juvenile myoclonic epilepsy (2022) (11)
Multipoint lods provide reliable linkage evidence despite unknown limiting distribution: type I error probabilities decrease with sample size for multipoint lods and mods (2008) (11)
Finding disease genes: a fast and flexible approach for analyzing high-throughput data (2011) (11)
Sa.26. Heterogeneity of the Psoriasis Phenotype Revealed by HLA Class I Haplotype Associations in Psoriatic Arthritis and Psoriasis (2008) (10)
Summary of analyses of problem 2 simulated data for GAW11 (1999) (10)
Using Linkage Analysis to Detect Gene-Gene Interactions. 2. Improved Reliability and Extension to More-Complex Models (2016) (9)
Linkage Analysis of Genomic Regions Contributing to the Expression of Type 1 Diabetes Microvascular Complications and Interaction with HLA (2015) (9)
Simulation study comparing interval estimates for the recombination fraction (1995) (8)
Multiple Subsampling of Dense SNP Data Localizes Disease Genes with Increased Precision (2009) (8)
The heterogeneity problem. I: Separating genetic from environmental forms of the same disease. (1985) (7)
Computer Simulation Is an Undervalued Tool for Genetic Analysis: A Historical View and Presentation of SHIMSHON – A Web-Based Genetic Simulation Package (2011) (7)
Using Linkage Analysis to Detect Gene-Gene Interaction by Stratifying Family Data on Known Disease, or Disease-Associated, Alleles (2014) (7)
Paraoxonase genes and susceptibility to ALS (2009) (7)
Mapping genes in juvenile myoclonic epilepsy. (1987) (7)
Better data analysis through data exploration. (1993) (7)
The Genetics of Febrile Seizures (2002) (7)
Major Susceptibility Genes for Common Idiopathic Epilepsies: ELP4 in Rolandic Epilepsy and BRD2 in Juvenile Myoclonic Epilepsy (2012) (7)
Robustness of Case-Control Studies to Population Stratification (2005) (6)
A comparison of multiplex and simplex families with Alzheimer's disease/senile dementia of Alzheimer type within a well defined population (1994) (6)
The Reliability of Haplotyping Inference in Nuclear Families: Misassignment Rates for SNPs and Microsatellites (2004) (6)
Identifying genetic risk loci for diabetic complications and showing evidence for heterogeneity of type 1 diabetes based on complications risk (2018) (6)
Next-generation linkage and association methods applied to hypertension: a multifaceted approach to the analysis of sequence data (2014) (6)
Replication, reanalysis, and gene expression: ME2 and genetic generalized epilepsy (2019) (6)
Developmental decrease in parvalbumin‐positive neurons precedes increase in flurothyl‐induced seizure susceptibility in the Brd2+/− mouse model of juvenile myoclonic epilepsy (2020) (6)
Brd2 haploinsufficiency extends lifespan and healthspan in C57B6/J mice (2020) (5)
Using Lod Scores to Detect Sex Differences in Male-Female Recombination Fractions (2004) (5)
Response to Visscher (2002) (5)
Genetic epidemiology and the search for epilepsy genes. (1999) (5)
Remind me again what disease we are studying? A population genetics, genetic analysis, and real data perspective on why progress on identifying genetic influences on common epilepsies has been so slow. (2014) (5)
Genetic Analysis Workshop 14: Introduction to Workshop Summaries (2005) (5)
The Rise and Fall and Rise of Linkage Analysis as a Technique for Finding and Characterizing Inherited Influences on Disease Expression. (2018) (4)
The Genetic Susceptibility to Type 1 (Insulin-Dependent) Diabetes Mellitus and the Autoimmune Thyroid Diseases (1999) (4)
Effect of Population Stratification on (2004) (3)
Is Juvenile Myoclonic Epilepsy Polygenic (1989) (3)
Perspectives: Clues in Mapping Epilepsy Genes (1989) (3)
The Essence of Linkage‐based Imprinting Detection: Comparing Power, Type 1 Error, and the Effects of Confounders in Two Different Analysis Approaches (2010) (3)
HLA and Epilepsy (1989) (3)
The choice of epilepsy syndromes for genetic analysis. (1991) (3)
Investigations of a Two-Locus Model for Coeliac Disease (1981) (3)
An Improved Delta-Centralization Method for Population Stratification (2011) (2)
Second-order approximations of ascertainment probabilities. (1980) (2)
Major Susceptibility Genes for Common Idiopathic Epilepsies (2012) (2)
Reply to Farrall. LOD wars: The affected-sib-pair paradigm strikes back! (1997) (2)
Genetic studies of typical Alzheimer's disease (1989) (2)
Genetics of juvenile myoclonic epilepsy (2005) (2)
Testing the simple 3‐allele model of inheritance of IDDM at the HLA‐associated locus (1986) (1)
NOS1AP Is a Genetic Modifier of Congenital Long-QT Syndrome (2009) (1)
Correction: Using Linkage Analysis to Detect Gene-Gene Interactions. 2. Improved Reliability and Extension to More-Complex Models (2016) (1)
Comments on: Review and Evaluation of Methods Correcting for Population Stratification with a Focus on Underlying Statistical Principles (2008) (1)
Sub-genic intolerance, ClinVar, and the epilepsies: A whole-exome sequencing study of 29,165 individuals. (2021) (1)
ELP4 in rolandic epilepsy and BRD2 in juvenile myoclonic epilepsy (2010) (1)
In Response: ME2 association analysis in adolescent‐onset genetic generalized epilepsy (2019) (1)
The application of jackknife statistics to estimates of the recombination fraction (1993) (1)
Subject Index Vol. 58, 2004 (2005) (0)
Figure 6, Sagittal sections of E11.5 embryos of wild-type and mutant embryos (2012) (0)
Figure 8, Seizure sensitivity to pentylenetetrazol in Wild-type and Brd2+/− mice (2012) (0)
30. Genetics of autism (2000) (0)
Figure 7, Whole-mount in situ hybridization of wild-type and Brd2 mutant E9.5 embryos using digoxygenin-labeled Brd2 RNA probes (2012) (0)
SLCO5A1 and synaptic assembly genes contribute to impulsivity in juvenile myoclonic epilepsy (2022) (0)
Contents Vol. 53, 2002 (2002) (0)
Response to comments on the paper “Blinders, phenotype, and fashionable genetic analysis: A critical examination of the current state of epilepsy genetic studies” (2011) (0)
Contents Vol. 58, 2004 (2005) (0)
Comments on ‘Delta-Centralization Fails to Control for Population Stratification in Genetic Association Studies’ (2010) (0)
AUTOSOMAL DOMINANT TRANSMISSION OF CENTROTEMPORAL SPIKES IN ROLANDIC EPILEPSY FAMILIES (2006) (0)
Genetics of juvenile myoclonic epilepsy: faulty components and faulty wiring? (2005) (0)
INVITED EDITORIAL The Emperor's New Methods (2003) (0)
Contributors and Participants (1982) (0)
Figure 2, Joint Analysis of Discovery (US) and Replication (Canadian) datasets (2012) (0)
84: Combined linkage-methylome analysis to uncover the molecular basis of racial disparities in preterm birth (PTB) (2020) (0)
Figure 9, Differences in density of parvalbumin-stained neurons in Brd2+/− vs WT in four brain regions: Cg1 – cingulated cortex, area 1; Prl – prelimbic cortex; IL – infralimbic cortex; DP – dorsal peduncular cortex (2012) (0)
Subject Index Vol. 69, 2010 (2010) (0)
The BTK Gene as Candidate Gene for Graves’ Disease (2000) (0)
The Genetics of Common Epilepsy Disorders: Lessons Learned from the Channelopathy Era (2014) (0)
Contents Vol. 72, 2011 (2011) (0)
BRD2: The First Locus Discovered for a Common Epilepsy (Juvenile Myoclonic Epilepsy): What Was Right, What Was Wrong, and How Studies of IGE Make Progress (2019) (0)
Contents Vol. 69, 2010 (2010) (0)
Subject Index Vol. 53, 2002 (2002) (0)
Figure 1, Pure likelihood plot of association evidence in discovery set and in joint analysis of data sets (Figure 2) (2012) (0)
How many false positives do we get when we maximize Zmax (1996) (0)
A linkage marker for schizophrenia and related disorders (1994) (0)
HLA Sharing and History of Miscarriage among Women with Rheumatoid Arthritis (2006) (0)
Contents, Vol. 43, 1993 (1993) (0)
Subject Index, Vol. 43, 1993 (1993) (0)
A neuroimaging correlate for a schizophrenia-related genetic marker in one pedigree (1995) (0)
Figure 5, Photographs of wild-type (Brd2−/−, left) and Brd2−/− (right) embryos at embryonic day (E) 9.5 of gestation (2012) (0)

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