David B. Rye
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Why Is David B. Rye Influential?
(Suggest an Edit or Addition)David B. Rye's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- International multicenter pilot study of the first comprehensive self‐completed nonmotor symptoms questionnaire for Parkinson's disease: The NMSQuest study (2006) (912)
- The metric properties of a novel non‐motor symptoms scale for Parkinson's disease: Results from an international pilot study (2007) (819)
- Cortical projections arising from the basal forebrain: A study of cholinergic and noncholinergic components employing combined retrograde tracing and immunohistochemical localization of choline acetyltransferase (1984) (740)
- Localization of D1 and D2 dopamine receptors in brain with subtype-specific antibodies. (1993) (616)
- The origins of cholinergic and other subcortical afferents to the thalamus in the rat (1987) (595)
- Pedunculopontine tegmental nucleus of the rat: Cytoarchitecture, cytochemistry, and some extrapyramidal connections of the mesopontine tegmentum (1987) (544)
- Prevalence of nonmotor symptoms in Parkinson's disease in an international setting; Study using nonmotor symptoms questionnaire in 545 patients (2007) (511)
- Review of the relationship of restless legs syndrome and periodic limb movements in sleep to hypertension, heart disease, and stroke. (2009) (384)
- Stabilization of the tetramethylbenzidine (TMB) reaction product: application for retrograde and anterograde tracing, and combination with immunohistochemistry. (1984) (365)
- Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD (2005) (321)
- Medullary and spinal efferents of the pedunculopontine tegmental nucleus and adjacent mesopontine tegmentum in the rat (1988) (307)
- Contributions of the pedunculopontine region to normal and altered REM sleep. (1997) (306)
- Microelectrode-guided pallidotomy: technical approach and its application in medically intractable Parkinson's disease. (1998) (303)
- Cholinergic and non-cholinergic septohippocampal pathways (1985) (303)
- A genetic risk factor for periodic limb movements in sleep. (2007) (295)
- An algorithm for the management of restless legs syndrome. (2004) (292)
- Choline acetyltransferase-immunoreactive neurons intrinsic to rodent cortex and distinction from acetylcholinesterase-positive neurons (1984) (279)
- Restless legs syndrome (2006) (274)
- Afferent projections to the cholinergic pedunculopontine tegmental nucleus and adjacent midbrain extrapyramidal area in the albino rat. I. Retrograde tracing studies (1992) (269)
- Substance P-Containing terminals in synaptic contact with cholinergic neurons in the neostriatum and basal forebrain: a double immunocytochemical study in the rat (1986) (268)
- Diagnostic standards for dopaminergic augmentation of restless legs syndrome: report from a World Association of Sleep Medicine-International Restless Legs Syndrome Study Group consensus conference at the Max Planck Institute. (2007) (247)
- A light and electron microscopic procedure for sequential double antigen localization using diaminobenzidine and benzidine dihydrochloride. (1986) (239)
- Emerging views of dopamine in modulating sleep/wake state from an unlikely source: PD. (2002) (215)
- Dopamine D5 receptor immunolocalization in rat and monkey brain (2000) (206)
- Immunochemical analysis of dopamine transporter protein in Parkinson's disease (1997) (197)
- Daytime sleepiness in Parkinson’s disease (2000) (185)
- Immunochemical Analysis of Vesicular Monoamine Transporter (VMAT2) Protein in Parkinson's Disease (1999) (183)
- Cholinergic vs. noncholinergic efferents from the mesopontine tegmentum to the extrapyramidal motor system nuclei (1988) (164)
- Chronic Interferon-α Decreases Dopamine 2 Receptor Binding and Striatal Dopamine Release in Association with Anhedonia-Like Behavior in Nonhuman Primates (2013) (144)
- Test-retest reliability of the multiple sleep latency test in narcolepsy without cataplexy and idiopathic hypersomnia. (2013) (143)
- Modulation of Vigilance in the Primary Hypersomnias by Endogenous Enhancement of GABAA Receptors (2012) (142)
- Challenges in diagnosing narcolepsy without cataplexy: a consensus statement. (2014) (139)
- Higher heart rate and reduced heart rate variability persist during sleep in chronic fatigue syndrome: A population-based study (2007) (129)
- Episodic neonatal hypoxia evokes executive dysfunction and regionally specific alterations in markers of dopamine signaling (2003) (112)
- Nigrostriatal collaterals to thalamus degenerate in parkinsonian animal models (2001) (111)
- Sleep Fragmentation and Motor Restlessness in a Drosophila Model of Restless Legs Syndrome (2012) (108)
- Parkinson's disease and RLS: the dopaminergic bridge. (2004) (108)
- Juvenile Parkinson’s disease with REM sleep behavior disorder, sleepiness, and daytime REM onset (1999) (107)
- The two faces of Eve (2004) (107)
- Daytime sleepiness in stable hemodialysis patients. (2003) (104)
- Chronic Interferon-Alpha Administration Disrupts Sleep Continuity and Depth in Patients with Hepatitis C: Association with Fatigue, Motor Slowing, and Increased Evening Cortisol (2010) (103)
- Colocalization of atriopeptin-like immunoreactivity with choline acetyltransferase-and substance P-like immunoreactivity in the pedunculopontine and laterodorsal tegmental nuclei in the rat (1986) (99)
- Nocturnal sleep, daytime sleepiness, and quality of life in stable patients on hemodialysis (2003) (98)
- Serotonergic dorsal raphe nucleus projections to the cholinergic and noncholinergic neurons of the pedunculopontine tegmental region: a light and electron microscopic anterograde tracing and immunohistochemical study (1997) (89)
- FAST TRACK: daytime sleepiness in Parkinson's disease. (2000) (87)
- Assessment of sleepiness and unintended sleep in Parkinson's disease patients taking dopamine agonists. (2003) (87)
- Sleep characteristics of persons with chronic fatigue syndrome and non-fatigued controls: results from a population-based study (2006) (84)
- Polysomnographic measures of nocturnal sleep in patients on chronic, intermittent daytime haemodialysis vs those with chronic kidney disease. (2005) (82)
- Randomized, double-blind, placebo-controlled, short-term trial of ropinirole in restless legs syndrome. (2005) (81)
- Augmentation as a treatment complication of restless legs syndrome: Concept and management (2007) (80)
- Disruptive Nocturnal Behavior in Parkinson's Disease and Alzheimer's Disease (1995) (79)
- Stabilization of TMB Reaction Product for electron microscopic retrograde and anterograde fiber tracing (1985) (78)
- Correlates of PLMs variability over multiple nights and impact upon RLS diagnosis. (2009) (77)
- Genetics of restless legs syndrome (RLS): State‐of‐the‐art and future directions (2007) (74)
- The Berlin Questionnaire Screens for Obstructive Sleep Apnea in Idiopathic Intracranial Hypertension (2011) (73)
- Reduced extracellular dopamine and increased responsiveness to novelty: neurochemical and behavioral sequelae of intermittent hypoxia. (2005) (71)
- Retrograde horseradish peroxidase tracing combined with localization of choline acetyltransferase immunoreactivity. (1984) (69)
- Cholinergic innervation displays strikingly different laminar preferences in several cortical areas (1986) (66)
- Clarithromycin in γ‐aminobutyric acid–Related hypersomnolence: A randomized, crossover trial (2015) (65)
- Inter-rater reliability for identification of REM sleep in Parkinson's disease. (2000) (65)
- Polymorphisms in hypocretin/orexin pathway genes and narcolepsy (2001) (64)
- Restless legs syndrome and periodic limb movement disorder. (2002) (63)
- The ICSD-3 and DSM-5 guidelines for diagnosing narcolepsy: clinical relevance and practicality (2016) (61)
- Excessive daytime sleepiness and unintended sleep in Parkinson’s disease (2006) (60)
- Inhibition of tumor necrosis factor improves sleep continuity in patients with treatment resistant depression and high inflammation (2015) (60)
- REM sleep behavior disorder and SCA-3 (Machado-Joseph disease) (2003) (59)
- Phasic muscle activity in sleep and clinical features of Parkinson disease (2010) (59)
- Restless legs syndrome, pica, and iron status in blood donors (2013) (58)
- Quantification of Electromyographic Activity During Sleep: A Phasic Electromyographic Metric (2006) (56)
- An update on the pathophysiology and genetics of restless legs syndrome (2008) (55)
- Obstructive sleep apnea in idiopathic intracranial hypertension: comparison with matched population data (2013) (55)
- Elevated PEM (phasic electromyographic metric) rates identify rapid eye movement behavior disorder patients on nights without behavioral abnormalities. (2008) (52)
- Hemodialysis disrupts basic sleep regulatory mechanisms: building hypotheses. (2000) (52)
- Flumazenil for the Treatment of Refractory Hypersomnolence: Clinical Experience with 153 Patients. (2016) (51)
- Elevated C-reactive protein is associated with severe periodic leg movements of sleep in patients with restless legs syndrome (2012) (51)
- The MSLT is Repeatable in Narcolepsy Type 1 But Not Narcolepsy Type 2: A Retrospective Patient Study. (2018) (51)
- Presentation of narcolepsy after 40 (1998) (49)
- Neonatal Intermittent Hypoxia Impairs Dopamine Signaling and Executive Functioning (2002) (49)
- Evidence continues to mount on the relationship of restless legs syndrome/ periodic limb movements in sleep to hypertension, cardiovascular disease, and stroke. (2010) (49)
- Narcolepsy in the Older Adult (2003) (47)
- Immunochemical Studies of Bovine and Human Choline‐O‐Acetyltransferase Using Monoclonal Antibodie (1982) (46)
- Restless legs syndrome and periodic leg movements of sleep. (2012) (46)
- Improvement in daytime sleepiness with clarithromycin in patients with GABA-related hypersomnia: Clinical experience (2014) (45)
- Presenilin‐1 protein expression in familial and sporadic Alzheimer's disease (1997) (44)
- Daytime alertness in Parkinson's disease: Potentially dose‐dependent, divergent effects by drug class (2012) (44)
- Regulation of CART mRNA in the rat nucleus accumbens via D3 dopamine receptors (2006) (42)
- Focus on the pedunculopontine nucleus. Consensus review from the May 2018 brainstem society meeting in Washington, DC, USA (2019) (42)
- A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis (2021) (40)
- Amelioration of sensory limb discomfort of restless legs syndrome by pallidotomy (1999) (40)
- Prolonged assessment of sleep and daytime sleepiness in unrestrained Macaca mulatta. (2006) (38)
- Restless legs syndrome in children with chronic kidney disease (2013) (37)
- Reversal of atypical depression, sleepiness, and REM‐sleep propensity in narcolepsy with bupropion (1998) (37)
- Colocalization of gamma-aminobutyric acid and acetylcholinesterase in rodent cortical neurons (1986) (36)
- Periodic leg movements in sleep in elderly patients with Parkinsonism and Alzheimer’s disease (2012) (35)
- Stabilization of the Tetramethylbenzidine (TMB) Reaction Product (1984) (35)
- Lowering dialysate temperature improves sleep and alters nocturnal skin temperature in patients on chronic hemodialysis (2007) (34)
- Restless abdomen (2011) (33)
- Solving the mysteries of narcolepsy (2001) (32)
- Effects of &ggr;-Aminobutyric Acid Type A Receptor Modulation by Flumazenil on Emergence from General Anesthesia (2016) (32)
- Daytime REM sleep in Parkinson's disease. (2013) (31)
- Animal models of RLS phenotypes. (2017) (31)
- Rotigotine's effect on PLM-associated blood pressure elevations in restless legs syndrome (2016) (30)
- Lesions in monkey globus pallidus externus exacerbate parkinsonian symptoms (2006) (29)
- Greater Daytime Sleepiness in Subcortical Stroke Relative to Parkinson's Disease and Alzheimer's Disease (2002) (29)
- The distribution of Alz-50 immunoreactivity in the normal human brain (1993) (28)
- Sleepiness and unintended sleep in Parkinson’s disease (2003) (28)
- Genetics of restless legs syndrome. (2006) (27)
- Wake promoting effects of cocaine and amphetamine-regulated transcript (CART) (2010) (25)
- Cortical asymmetry of REM sleep EEG following unilateral pontine hemorrhage (1991) (24)
- Where you least expect it: dopamine in the pons and modulation of sleep and REM-sleep. (2003) (24)
- The molecular basis of restless legs syndrome (2013) (24)
- A Prospective Photographic Study of the Ocular Fundus in Obstructive Sleep Apnea (2013) (22)
- Ultrastructural study of cholinergic and noncholinergic neurons in the pars compacta of the rat pedunculopontine tegmental nucleus (1997) (22)
- Large genome-wide association study identifies three novel risk variants for restless legs syndrome (2020) (21)
- Tracking neural pathways with MRI (1999) (21)
- The Molecular Genetics of Restless Legs Syndrome. (2015) (20)
- Ultrastructural study of cholinergic and noncholinergic neurons in the pars compacta of the rat pedunculopontine tegmental nucleus. (1997) (20)
- Anatomical Investigations of the Pallidotegmental Pathway in Monkey and Man (1996) (18)
- Hypersomnia: Evaluation, Treatment, and Social and Economic Aspects. (2017) (16)
- Consensus Guidelines on Rodent Models of Restless Legs Syndrome (2020) (15)
- Narcolepsy in the Older Adult Epidemiology, Diagnosis and Management (2012) (15)
- Modulation of normal and pathologic motoneuron activity during sleep: insights from the neurology clinic, Parkinson's disease, and comments on parkinsonian-related sleepiness. (2002) (14)
- A Hybrid Approach for Artifact Detection in EEG Data (2010) (14)
- Narcolepsy risk loci are enriched in immune cells and suggest autoimmune modulation of the T cell receptor repertoire (2018) (14)
- Wavelet analysis for detection of phasic electromyographic activity in sleep: Influence of mother wavelet and dimensionality reduction (2014) (13)
- Intradialytic subjective sleepiness and oral body temperature. (2000) (13)
- High dose CART peptide induces abnormal EEG activity and behavioral seizures (2008) (13)
- Differences in the retinohypothalamic tract in albino lewis versus brown norway rat strains (1993) (12)
- Neurochemistry of Sleep and Wakefulness: Dopamine in behavioral state control (2008) (11)
- Insomnia on dialysis nights: the beneficial effects of cool dialysate. (2008) (11)
- Falling asleep at the wheel: motor vehicle mishaps in people taking pramipexole and ropinirole. (2000) (10)
- Excessive Daytime Sleepiness and Functioning in Dialysis Patients (1999) (9)
- Systemic exertion intolerance disease/chronic fatigue syndrome is common in sleep centre patients with hypersomnolence: A retrospective pilot study (2019) (9)
- Seeing beyond one's nose: Sleep disruption and excessive sleepiness accompany motor disability in the MPTP treated primate (2010) (8)
- Restless legs syndrome. (2011) (8)
- Functional Organization of Brainstem-Basal Ganglia Interactions as Viewed from the Pedunculopontine Region (2001) (8)
- Regional brain metabolism differentiates narcolepsy type 1 and idiopathic hypersomnia. (2021) (8)
- Daytime Sleepiness and Sleep Attacks in Idiopathic Parkinson’s Disease (2003) (7)
- Inter-rater agreement for visual discrimination of phasic and tonic electromyographic activity in sleep (2018) (7)
- TOX3 gene variant could be associated with painful restless legs. (2019) (7)
- Phasic Electromyographic Metric detection based on wavelet analysis (2011) (6)
- Heart rate changes accompanying periodic leg movements during sleep in narcoleptic patients. (2011) (5)
- Further experience using clarithromycin in patients with Kleine-Levin syndrome. (2014) (5)
- Comment on Shpirer et al. (“Excessive daytime sleepiness in patients with Parkinson's disease: A polysomnographic study”) (2007) (5)
- Sleep/Wake Behavior and EEG Signatures of the TgF344-AD Rat Model at the Prodromal Stage (2020) (5)
- Cerebrospinal Fluid Hypocretin and Nightmares in Dementia Syndromes (2021) (5)
- Frequency of multiple sleep onset REM periods in "control" subjects. (1997) (5)
- Retrograde Horseradish Peroxidase Tracing Combined with Localization of Choline Acetyltransferase mm1 (1984) (4)
- Hypocretin measurement: shelf age of radioimmunoassay kit, but not freezer time, influences assay variability (2017) (4)
- What should we be measuring? Defining the "P" in PLMS. (2006) (4)
- Neurobiology of sleep: the role of dopamine in Parkinson’s disease (2009) (4)
- Restless legs syndrome with augmentation successfully treated with IV iron. (2017) (3)
- Inability to replicate cerebrospinal fluid histamine deficits in the primary hypersomnias: a back to the drawing board moment. (2012) (3)
- Dopaminergic Substrates Underlying Hypersomnia, Sleepiness, and REM Sleep Expression (2011) (3)
- Frequency of and Factors Associated With Obstructive Sleep Apnea and Periodic Limb Movements in Stroke and TIA Patients (2018) (3)
- Challenges in diagnosing narcolepsy without cataplexy (2014) (3)
- Idiopathic recurrent stupor: Munchausen by proxy and medical litigation. (2014) (3)
- Erratum to “Diagnostic standards for dopaminergic augmentation of restless legs syndrome: Report from a World Association of Sleep Medicine – International Restless Legs Syndrome Study Group consensus conference at the Max Planck Institute” [Sleep Med. 8 (2007) 520–530] (2007) (2)
- Rigor, reproducibility, and in vitro cerebrospinal fluid assays: The devil in the details (2017) (2)
- SYMBOLIC REPRESENTATION OF HUMAN ELECTROMYOGRAMS FOR AUTOMATED DETECTION OF PHASIC ACTIVITY DURING SLEEP (2014) (2)
- Paradoxical Sleep Suppresses Immediate Early Gene Expression in the Rodent Suprachiasmatic Nuclei (2010) (2)
- Postnatal hypoxia evokes persistent changes within the male rat’s dopaminergic system (2018) (2)
- Paralysis lost: a new cause for a common parasomnia? (2014) (2)
- An open-label study of the efficacy, safety and tolerability of oral BTD-001 in adults with idiopathic hypersomnia or narcolepsy type 2 (2017) (1)
- Chapter 11 – The Brain's Dopamine Systems and Their Relevance to Restless Legs Syndrome (2009) (1)
- Parkinson’s disease and sleep (2004) (1)
- Relief in sight for restless legs syndrome (2004) (1)
- 0627 Initial Use of the Sleep Inertia Questionnaire in Hypersomnolence Disorders (2019) (1)
- Vesicular monoamine transporter immunoreactivity is reduced in Parkinsons diseased striatum (1996) (1)
- Semi-Automated Annotation of Phasic Electromyographic Activity (2014) (1)
- Effect Of Rotigotine Transdermal System On Nocturnal Blood Pressure Changes Associated With Periodic Limb Movements During Sleep In Patients With Restless Legs Syndrome (P5.268) (2014) (1)
- International validation study of the first comprehensive unified Nonmotor Symptoms Scale (NMSS) for Parkinson's disease (PD) (2006) (1)
- 0658 FREQUENCY AND PREDICTORS OF SYSTEMIC EXERTION INTOLERANCE DISEASE/CHRONIC FATIGUE SYNDROME AMONG SLEEP CENTER PATIENTS REFERRED FOR HYPERSOMNOLENCE EVALUATION (2017) (0)
- Neurobiology of sleep: the role of dopamine in Parkinson’s disease-related sleep disorders (2014) (0)
- Reply (2011) (0)
- Effects of 24-h Transdermal Delivery of Rotigotine on the Core Symptoms and Symptom Impact of Restless Legs Syndrome/Willis-Ekbom Disease: A Post Hoc Analysis of IRLS Single Item Data from a 6-Month Placebo-Controlled European Study (P04.037) (2012) (0)
- Obstructive Sleep Apnea in Idiopathic Intracranial Hypertension: Comparison with Matched Population Data (P07.261) (2012) (0)
- Rye ReceptorsAEnhancement of GABA Modulation of Vigilance in the Primary Hypersomnias by Endogenous (2012) (0)
- Chapter 9 Future directions (2009) (0)
- 0658 Phenotypic Characterization Of Rls In African-americans (2019) (0)
- immunotherapies, and by a presumptive role of neural- cell adhesion molecules in the modulation of REM-sleep (2014) (0)
- 96. Chronic IFN-alpha administration reduces basal ganglia dopamine release in rhesus monkeys: Preliminary results from in vivo microdialysis and neuroimaging (2011) (0)
- 0769 FDG-PET Imaging In Narcolepsy Type 1, Idiopathic Hypersomnia, And Non-Sleepy Controls (2020) (0)
- Sleepiness: Excessive daytime sleepiness in Parkinson's disease (2011) (0)
- Rotigotine Improves Core Symptoms and Symptom Impact in Patients with Restless Legs Syndrome/Willis-Ekbom Disease: A Post Hoc Analysis of IRLS Single Item Data from a 6-Month Placebo-Controlled US Study (P04.032) (2012) (0)
- hronic Interferon-Alpha Administration Disrupts leep Continuity and Depth in Patients with Hepatitis : Association with Fatigue, Motor Slowing, and ncreased Evening Cortisol (0)
- Restless legs syndrome: treatment options (2008) (0)
- Author's Reply (1996) (0)
- 0617 Working Memory and Psychomotor Vigilance Performance After Brief Naps in Hypersomnolent Patients: MSLT Correlates (2018) (0)
- Chapter 21 The nocturnal manifestations of waking movement disorders: focus on Parkinson's disease (2005) (0)
- Obituary for Charlotte McCutchen, MD. (2013) (0)
- Towards a fully automated tool for annotation of phasic electromyographic activity (2016) (0)
- Restless legs syndrome and periodic limb movement disorder : Sleep disorders (2002) (0)
- Chapter 24 – Restless Legs Syndrome and Periodic Limb Movement Disorders (2012) (0)
- RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY INVESTIGATING CHANGES IN NOCTURNAL BLOOD PRESSURE ELEVATIONS ASSOCIATED WITH PERIODIC LEG MOVEMENTS FOLLOWING TREATMENT WITH ROTIGOTINE IN PATIENTS WITH RESTLESS LEGS SYNDROME (WILLIS-EKBOM DISEASE) (2014) (0)
- Acknowledgment of reviewers (1994) (0)
- Respect for muscle. (2012) (0)
- Chapter 5 Differential diagnosis of restless legs syndrome (2009) (0)
- RESTLESS LEGS SYNDROME (RLS) IS CHARACTER- IZED BY (A) A DESIRE TO MOVE THE LEGS OFTEN, BUT NOT NECESSARILY, ACCOMPANIED BY ABNORMAL (2009) (0)
- Impaired consciousness states in myotonic dystrophy-type 1 mediation by γ-amino butyric acid (GABA) (2017) (0)
- PTPRD expression regulates sleep consolidation in Drosophila (2013) (0)
- 0600 Visual Processing Speed After Brief Naps in Hypersomnolent Patients: MSLT and PVT Correlates (2019) (0)
- 0653 WORSENING PSYCHOMOTOR VIGILANCE AFTER BRIEF NAPS IN HYPERSOMNOLENT PATIENTS: MSLT NAP CORRELATES (2017) (0)
- 0663 Buprenorphine/naloxone Treatment Of Refractory RLS (2019) (0)
- Chapter 3 Epidemiology (2009) (0)
- Cytoarchitectonic cytochemical features of the nucleus tegmenti pedunculopontinus in the rat are distinct from extrapyramidal projections to the mesopontine tegmentum (1985) (0)
- 0622 The Psychomotor Vigilance Task as a Diagnostic Tool for Hypersomnolence (2019) (0)
- Photographic Assessment of Optic Disc and Retinal Vasculature in Obstructive Sleep Apnea (OSA) Patients (P07.262) (2012) (0)
- Sleep medicine. Contemporary neurology series, vol 53 (2000) (0)
- In Reply. (2017) (0)
- New approaches to the study of periodic leg movements during sleep in restless legs syndrome. Commentary (2006) (0)
- Commonly Used Therapeutics Associated with Changes in Arousal Inhibit GABAAR Activation (2023) (0)
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What Schools Are Affiliated With David B. Rye?
David B. Rye is affiliated with the following schools:
