David Barford
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British medical researcher
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David Barford's Degrees
- Bachelors Biology University of Oxford
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Why Is David Barford Influential?
(Suggest an Edit or Addition)According to Wikipedia, David Barford is a British medical researcher and structural biologist at the MRC Laboratory of Molecular Biology Cambridge, UK. Education Barford studied Biochemistry at the University of Bristol and then went on to earn a Doctor of Philosophy from the University of Oxford, supervised by Professor Dame Louise Johnson.
David Barford's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF (2004) (2524)
- Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate (2003) (865)
- The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR‐mediated protein–protein interactions (1998) (802)
- Crystal structure of human protein tyrosine phosphatase 1B. (1994) (690)
- The structure and mechanism of protein phosphatases: insights into catalysis and regulation. (1998) (682)
- Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases. (1997) (676)
- Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1 (1997) (603)
- Molecular discrimination of structurally equivalent Lys 63‐linked and linear polyubiquitin chains (2009) (572)
- A Family with Severe Insulin Resistance and Diabetes Due to a Mutation in AKT2 (2004) (555)
- Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B. (1995) (543)
- Structural insights into mRNA recognition from a PIWI domain–siRNA guide complex (2005) (528)
- TYK2 and JAK2 Are Substrates of Protein-tyrosine Phosphatase 1B* (2001) (465)
- Crystal structure of an activated Akt/Protein Kinase B ternary complex with GSK3-peptide and AMP-PNP (2002) (458)
- The Structure of the Protein Phosphatase 2A PR65/A Subunit Reveals the Conformation of Its 15 Tandemly Repeated HEAT Motifs (1999) (449)
- The Crystal Structure of Human Eukaryotic Release Factor eRF1—Mechanism of Stop Codon Recognition and Peptidyl-tRNA Hydrolysis (2000) (447)
- Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution. (1996) (429)
- Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation. (2002) (426)
- Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B. (2000) (420)
- Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization. (2005) (404)
- Molecular mechanisms of the protein serine/threonine phosphatases. (1996) (372)
- Crystal structure of the catalytic subunit of human protein phosphatase 1 and its complex with tungstate. (1995) (369)
- Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity (2004) (352)
- Topological characteristics of helical repeat proteins. (1999) (341)
- Getting into position: the catalytic mechanisms of protein ubiquitylation. (2004) (322)
- The role of cysteine residues as redox-sensitive regulatory switches. (2004) (310)
- Structure of the mitotic checkpoint complex (2012) (310)
- PTPN11 (Shp2) Mutations in LEOPARD Syndrome Have Dominant Negative, Not Activating, Effects* (2006) (309)
- Functions and mechanisms of redox regulation of cysteine-based phosphatases. (2005) (298)
- Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2. (1998) (282)
- The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module. (2008) (275)
- The effects of phosphorylation on the structure and function of proteins. (1993) (268)
- Molecular basis of AKAP specificity for PKA regulatory subunits. (2006) (265)
- The allosteric transition of glycogen phosphorylase (1989) (260)
- A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK (2011) (232)
- The structure of cat muscle pyruvate kinase. (1986) (221)
- Structural mechanism for glycogen phosphorylase control by phosphorylation and AMP. (1992) (218)
- Molecular basis for TPR domain‐mediated regulation of protein phosphatase 5 (2005) (207)
- Visualization of the Cysteinyl-phosphate Intermediate of a Protein-tyrosine Phosphatase by X-ray Crystallography* (1998) (206)
- Structures of APC/CCdh1 with substrates identify Cdh1 and Apc10 as the D-box co-receptor (2010) (206)
- Doc1 mediates the activity of the anaphase‐promoting complex by contributing to substrate recognition (2003) (206)
- Atomic structure of the APC/C and its mechanism of protein ubiquitination (2015) (200)
- Molecular architecture and mechanism of the anaphase-promoting complex (2014) (181)
- Structural basis for the subunit assembly of the anaphase-promoting complex (2011) (177)
- Protein tyrosine phosphatases take off (1995) (173)
- Structure of the A20 OTU domain and mechanistic insights into deubiquitination. (2008) (173)
- Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2. (2001) (173)
- Argonaute: A scaffold for the function of short regulatory RNAs. (2006) (167)
- Conservation analysis and structure prediction of the protein serine/threonine phosphatases. Sequence similarity with diadenosine tetraphosphatase from Escherichia coli suggests homology to the protein phosphatases. (1994) (166)
- Molecular basis of APC/C regulation by the spindle assembly checkpoint (2016) (166)
- KSR2 Mutations Are Associated with Obesity, Insulin Resistance, and Impaired Cellular Fuel Oxidation (2013) (158)
- Expression, purification, crystallization, and biochemical characterization of a recombinant protein phosphatase. (1993) (153)
- Molecular mechanism of APC/C activation by mitotic phosphorylation (2016) (152)
- The structure of the cell cycle protein Cdc14 reveals a proline‐directed protein phosphatase (2003) (144)
- Mechanism of farnesylated CAAX protein processing by the integral membrane protease Rce1 (2013) (140)
- Enhancement of the Seed-Target Recognition Step in RNA Silencing by a PIWI/MID Domain Protein (2009) (135)
- Differential Oxidation of Protein-tyrosine Phosphatases* (2005) (130)
- Conformation-Sensing Antibodies Stabilize the Oxidized Form of PTP1B and Inhibit Its Phosphatase Activity (2011) (129)
- Protein phosphatases. (1995) (129)
- Insights into Degron Recognition by APC/C Coactivators from the Structure of an Acm1-Cdh1 Complex (2013) (125)
- Regulation of A20 and other OTU deubiquitinases by reversible oxidation (2013) (121)
- Crystal structure and functional analysis of the eukaryotic class II release factor eRF3 from S. pombe. (2004) (121)
- Identification of inhibitors of protein kinase B using fragment-based lead discovery. (2007) (120)
- Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C) (2017) (112)
- Insights into the anaphase-promoting complex: a molecular machine that regulates mitosis. (2014) (110)
- Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics. (1998) (108)
- Structure of the SARS-CoV-2 RNA-dependent RNA polymerase in the presence of favipiravir-RTP (2021) (106)
- Structure, function and mechanism of the anaphase promoting complex (APC/C) (2010) (100)
- Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13 (2018) (98)
- Catalysis in the crystal: synchrotron radiation studies with glycogen phosphorylase b. (1987) (97)
- An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signaling. (2008) (95)
- Reversible oxidation of the membrane distal domain of receptor PTPalpha is mediated by a cyclic sulfenamide. (2007) (93)
- Sorafenib Functions to Potently Suppress RET Tyrosine Kinase Activity by Direct Enzymatic Inhibition and Promoting RET Lysosomal Degradation Independent of Proteasomal Targeting* (2007) (91)
- Structural analysis of the anaphase-promoting complex reveals multiple active sites and insights into polyubiquitylation. (2005) (90)
- Architecture and dynamics of an A-kinase anchoring protein 79 (AKAP79) signaling complex (2011) (89)
- Structural insights into anaphase-promoting complex function and mechanism (2011) (87)
- Molecular recognition via coupled folding and binding in a TPR domain. (2005) (84)
- Multiple Factors Confer Specific Cdc42 and Rac Protein Activation by Dedicator of Cytokinesis (DOCK) Nucleotide Exchange Factors* (2011) (84)
- Structure of the inner kinetochore CCAN complex assembled onto a centromeric nucleosome (2019) (84)
- Lining the pockets of kinases and phosphatases. (2006) (81)
- Crystal structure of the M‐fragment of α‐catenin: implications for modulation of cell adhesion (2001) (79)
- Conformational diversity in the TPR domain-mediated interaction of protein phosphatase 5 with Hsp90. (2006) (78)
- Structure of TOR and its complex with KOG1. (2007) (78)
- Protein-oligosaccharide interactions: lysozyme, phosphorylase, amylases. (1988) (77)
- A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera. (2007) (76)
- Regulation of protein kinases in insulin, growth factor and Wnt signalling. (2002) (75)
- Glycogen phosphorylase. The structural basis of the allosteric response and comparison with other allosteric proteins. (1990) (70)
- The structure of the 26S proteasome subunit Rpn2 reveals its PC repeat domain as a closed toroid of two concentric α-helical rings. (2012) (69)
- Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure (2008) (67)
- The APC/C subunit Cdc16/Cut9 is a contiguous tetratricopeptide repeat superhelix with a homo‐dimer interface similar to Cdc27 (2010) (65)
- Structural studies with inhibitors of the cell cycle regulatory kinase cyclin-dependent protein kinase 2. (2002) (63)
- Coactivator functions in a stoichiometric complex with anaphase‐promoting complex/cyclosome to mediate substrate recognition (2005) (62)
- Further evidence that inhibitor‐2 acts like a chaperone to fold PP1 into its native conformation (1996) (60)
- Crystal structure of the PP2A phosphatase activator: implications for its PP2A-specific PPIase activity. (2006) (55)
- AKAP18 contains a phosphoesterase domain that binds AMP. (2008) (54)
- Protein-Tyrosine Phosphatase Inhibition by a Peptide Containing the Phosphotyrosyl Mimetic, L-O-Malonyltyrosine (L-OMT) (1995) (52)
- Mechanism of isoprenylcysteine carboxyl methylation from the crystal structure of the integral membrane methyltransferase ICMT. (2011) (49)
- Recombinant expression, reconstitution and structure of human anaphase-promoting complex (APC/C). (2013) (49)
- Implications for the ubiquitination reaction of the anaphase-promoting complex from the crystal structure of the Doc1/Apc10 subunit. (2002) (49)
- Cryo-EM structure of a separase-securin complex at near-atomic resolution (2017) (48)
- The molecular mechanism for the tetrameric association of glycogen phosphorylase promoted by protein phosphorylation (1992) (46)
- Eliminylation: a post-translational modification catalyzed by phosphothreonine lyases. (2009) (46)
- Purification and crystallization of the catalytic domain of human protein tyrosine phosphatase 1B expressed in Escherichia coli. (1994) (46)
- Catalysis in enzyme crystals. (1988) (44)
- Crystallographic binding studies on the allosteric inhibitor glucose-6-phosphate to T state glycogen phosphorylase b. (1993) (43)
- Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase. (2005) (40)
- The structure of Tap42/alpha4 reveals a tetratricopeptide repeat-like fold and provides insights into PP2A regulation. (2007) (39)
- Recombinant expression and reconstitution of multiprotein complexes by the USER cloning method in the insect cell-baculovirus expression system. (2016) (37)
- Pyridoxal phosphate site in glycogen phosphorylase b: structure in native enzyme and in three derivatives with modified cofactors. (1987) (34)
- Co-crystallization of the catalytic subunit of the serine/threonine specific protein phosphatase 1 from human in complex with microcystin LR. (1994) (33)
- Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C (2019) (32)
- Molecular mechanism of target RNA transcript recognition by Argonaute-guide complexes. (2006) (31)
- Channels at the catalytic site of glycogen phosphorylase b: binding and kinetic studies with the beta-glycosidase inhibitor D-gluconohydroximo-1,5-lactone N-phenylurethane. (1988) (31)
- Structural interconversions of the anaphase-promoting complex/cyclosome (APC/C) regulate cell cycle transitions. (2019) (31)
- Catalytic mechanism of glycogen phosphorylase. (1992) (31)
- Structural basis of human separase regulation by securin and CDK1–cyclin B1 (2021) (31)
- Structure of the DOCK2−ELMO1 complex provides insights into regulation of the auto-inhibited state (2020) (30)
- Pellino1 Is Required for Interferon Production by Viral Double-stranded RNA* (2012) (30)
- Electrostatic effects in the control of glycogen phosphorylase by phosphorylation (1994) (29)
- Baculovirus expression: tackling the complexity challenge (2013) (27)
- Molecular structure of the N-terminal domain of the APC/C subunit Cdc27 reveals a homo-dimeric tetratricopeptide repeat architecture. (2010) (27)
- Crystal structure of an activated Akt/protein kinase B (PKB-PIF chimera) ternary complex with AMP-PNP and GSK3 peptide (2002) (26)
- The potential of cryo-electron microscopy for structure-based drug design. (2017) (24)
- Purification and assay of the budding yeast anaphase-promoting complex. (2005) (24)
- Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome (2022) (23)
- The Four Canonical TPR Subunits of Human APC/C Form Related Homo-Dimeric Structures and Stack in Parallel to Form a TPR Suprahelix☆ (2013) (22)
- Molecular discrimination of structurally equivalent Lys 63‐linked and linear polyubiquitin chains (2009) (20)
- TETRATRICOPEPTIDE REPEATS OF PROTEIN PHOSPHATASE 5 (1998) (19)
- Redox Regulation of Protein Tyrosine Phosphatase Involves a Sulfenyl-Amide Intermediate (2003) (18)
- Time-resolved structural studies on catalysis in the crystal with glycogen phosphorylase b. (1986) (16)
- Molecular mechanism of Mad1 kinetochore targeting by phosphorylated Bub1 (2021) (16)
- Architecture of the CBF3-Centromere Complex of the Budding Yeast Kinetochore (2018) (16)
- The mechanism of protein kinase regulation by protein phosphatases. (2001) (15)
- WD40 domain of Apc1 is critical for the coactivator-induced allosteric transition that stimulates APC/C catalytic activity (2016) (15)
- Getting in the Ring: Proline-Directed Substrate Specificity in the Cell Cycle Proteins Cdc14 and CDK2-CyclinA3 (2003) (14)
- Crystal structure of the Cenp-HIKHead-TW sub-module of the inner kinetochore CCAN complex (2020) (13)
- A unique binding mode of Nek2A to the APC/C allows its ubiquitination during prometaphase (2020) (13)
- Understanding the structural basis for controlling chromosome division (2015) (11)
- Data collection with a tailored X-ray beam size at 2.69 Å wavelength (4.6 keV): sulfur SAD phasing of Cdc23Nterm (2016) (11)
- Control of phosphorylase b conformation by a modified cofactor: Crystallographic studies on R‐state glycogen phosphorylase reconstituted with pyridoxal 5′‐diphosphate (1992) (10)
- PROTEIN TYROSINE PHOSPHATASE 1B CYSTEINYL-PHOSPHATE INTERMEDIATE (1998) (9)
- Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain (2015) (9)
- From phosphorylase to phosphorylase kinase. (1997) (8)
- The Structure and Topology of Protein Serine/Threonine Phosphatases (2010) (8)
- Supplemental Data The Structure of the CYLD USP Domain Explains Its Specificity for Lys 63-Linked Polyubiquitin and Reveals a B Box Module (2008) (8)
- Molecular mechanisms of APC/C release from spindle assembly checkpoint inhibition by APC/C SUMOylation (2021) (7)
- Juxtaposition of Bub1 and Cdc20 on phosphorylated Mad1 during catalytic mitotic checkpoint complex assembly (2022) (7)
- Purification and crystallization of the CDK‐associated protein phosphatase KAP expressed in escherichia coli (1998) (6)
- The APC/C targets the Cep152–Cep63 complex at the centrosome to regulate mitotic spindle assembly (2021) (6)
- Building a pseudo-atomic model of the anaphase-promoting complex (2013) (6)
- Methods for preparing crystals of reversibly oxidized proteins: crystallization of protein tyrosine phosphatase 1B as an example. (2008) (5)
- Protein-tyrosine phosphatase inhibition by a peptide containing the phosphotyrosyl mimetic, L-O-malonyltyrosine. (1995) (5)
- The APC / C subunit Cdc 16 is a contiguous tetratricopeptide superhelix with a homodimer interface similar to Cdc 27 (2010) (5)
- Catalysis in the crystal: synchrotron radiation studies with glycogen phosphorylase b (1987) (5)
- Structural basis for the inhibition of the SARS-CoV-2 RNA-dependent RNA polymerase by favipiravir-RTP (2020) (4)
- Structural biology of DOCK‐family guanine nucleotide exchange factors (2022) (3)
- Cryo-EM structure of the CBF3-core-Ndc10-DBD complex of the budding yeast kinetochore (2018) (3)
- Phosphate-recognition sites in catalysis and control of glycogen phosphorylase b. (1987) (3)
- The Role of Multiple Sequence Repeat Motifs in the Assembly of Multi-protein Complexes (2012) (2)
- Sorafenib functions to potently suppress RET tyrosine kinase activity by direct enzymatic inhibition and promoting RET lysosomal degradation independent of proteasomal targeting. (2009) (2)
- Germline Missense Variants in CDC20 Result in Aberrant Mitotic Progression and Familial Cancer (2021) (2)
- Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1 location , organelle or process (2013) (2)
- Solid state 31P cross-polarization/magic angle sample spinning nuclear magnetic resonance of crystalline glycogen phosphorylase b. (1993) (2)
- Structure of the mitotic checkpoint (2012) (2)
- Crystal structure of a complex between PTP1B and the insulin receptor tyrosine kinase (2005) (2)
- A Raf-Induced Allosteric Transition of Ksr Stimulates Ksr and Raf Phosphorylation of Mek (2011) (2)
- Signal transduction proteins: Structural basis of control by phosphorylation (1999) (1)
- Nsp7-Nsp8-Nsp12 SARS-CoV2 RNA-dependent RNA polymerase in complex with template:primer dsRNA and favipiravir-RTP (2020) (1)
- Biasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration (2022) (1)
- Structure of the proline directed phosphatase cdc14 (2003) (1)
- Structural studies of protein phosphatases (1997) (1)
- Louise N. Johnson 1940–2012 (2012) (1)
- CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH PHOSPHOTYROSINE (1996) (1)
- CRYSTAL STRUCTURE OF THE PP2A PHOSPHATASE ACTIVATOR Ypa1 PTPA1 (2006) (1)
- Faculty Opinions recommendation of X-ray structure of a voltage-dependent K+ channel. (2003) (0)
- structure of cdc14 in complex with tungstate (2003) (0)
- Negative feedback between the APC/C and Cep152 at the centrosome regulates mitotic spindle assembly (2020) (0)
- Solution structure of the TPR domain from Protein phosphatase 5 in complex with Hsp90 derived peptide (2006) (0)
- Atomic structure of the human Anaphase-Promoting Complex (2015) (0)
- Glycogen Phosphorylase b (2020) (0)
- Structure of inner kinetochore CCAN complex with mask1 (2019) (0)
- CryoEM structure of the binary DOCK2-ELMO1 complex (2020) (0)
- Decision letter: Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme (2020) (0)
- CRYSTAL STRUCTURE OF THE PP2A PHOSPHATASE ACTIVATOR Ypa2 PTPA2 (2006) (0)
- STRUCTURE OF THE COMPLEX BETWEEN Dock2 AND Rac1. (2011) (0)
- Structure of protein kinase B unphosphorylated (2003) (0)
- Structure of the A20 Ovarian Tumour (OTU) domain (2007) (0)
- crystal structure of Lys63-linked di-ubiquitin (2008) (0)
- Methods for Preparing Cryo-EM Grids of Large Macromolecular Complexes. (2018) (0)
- 20 B-RAF is an oncogene and therapeutic target in melanoma (2004) (0)
- SUMOylated apoAPC/C with repositioned APC2 WHB domain (2021) (0)
- Cryo-EM structure of the CBF3-msk complex of the budding yeast kinetochore (2018) (0)
- Structure of inner kinetochore CCAN complex (2019) (0)
- HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH TPI (1999) (0)
- Structure of PKA-PKB chimera complexed with 4-(4-chloro-phenyl)-4-(4- (1H-pyrazol-4-yl)-phenyl)-piperidine (2007) (0)
- Structure of PKA-PKB chimera complexed with A-443654 (2007) (0)
- CHAPTER 101 – The Structure and Topology of Protein Serine/Threonine Phosphatases (2003) (0)
- G83N TPR domain of Ppp5 (2006) (0)
- Orthorhombic P21212 Structure of Human Mad1 C-terminal Domain in Complex with Phosphorylated Bub1 CD1 Domain (0)
- A20 OTU domain in reversibly oxidised (SOH) state (2013) (0)
- A20 OTU domain in reduced, active state at 1.87 A resolution (2013) (0)
- Protein tyrosine phosphatases: X-ray crystallographic observation of cysteinyl-phosphate reaction intermediate. (2002) (0)
- AKAP18 delta central domain (2008) (0)
- Structure of the complex between DOCK9 and Cdc42. (2009) (0)
- 332 Fragment-based and structure based optimisation of potent PKB/AKT inhibitors (2004) (0)
- Abstract PR13: Germ-line mutations in CDC20 result in familial cancers via deregulation of the cell cycle (2016) (0)
- Interaction of the catalytic subunit of protein phosphatase 1 (1997) (0)
- The Structure of Tap42 Alpha4 Subunit (2007) (0)
- HUMAN RECEPTOR PROTEIN TYROSINE PHOSPHATASE MU, DOMAIN 1 (1998) (0)
- CryoEM structure of the human Separase-Securin complex (2021) (0)
- CryoEM structure of the ternary DOCK2-ELMO1-RAC1 complex (2020) (0)
- Structure and mechanisms of protein phosphatases (2010) (0)
- Faculty Opinions recommendation of Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. (2002) (0)
- APC10/DOC1 SUBUNIT OF S. cerevisiae (2002) (0)
- 109 Identification of small molecule inhibitors of PKB/AKT in a high throughput screen (2004) (0)
- Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Mitotic checkpoint complex (APC/C-MCC) at 3.8 angstrom resolution (2020) (0)
- Structure-based design of small molecule protein-tyrosine phosphatase inhibitors (2002) (0)
- Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D1 box class (2019) (0)
- Structure of the Chromobacterium violaceum VirA (SpvC) Phosphothreonine Lyase effector protein (2008) (0)
- A20 OTU domain with irreversibly oxidised Cys103 from 270 min H2O2 soak. (2013) (0)
- Crystal Structure of the ELMO1 PH domain (2009) (0)
- Structural basis for phosphopeptide recognition and catalysis by protein phosphatases (1996) (0)
- Thestructure ofcatmuscle pyruvate kinase (1986) (0)
- sulfur SAD phasing of Cdc23Nterm: data collection with a tailored X- ray beam size at 2.69 A wavelength (4.6 keV) (2016) (0)
- Mechanism of Protein Kinase Inactivation by Protein Phosphatases (2001) (0)
- Cryo-EM structure of combined apo phosphorylated APC (2016) (0)
- Structure of cdc14b phosphatase with a peptide ligand (2003) (0)
- Crystal structure of the kinetochore subunits H/I/K/T/W penta-complex from S. cerevisiae at 2.9 angstroms (2020) (0)
- Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Nek2A substrate at 3.9 angstrom resolution (2020) (0)
- The N-terminal WD40 domain of Apc1 (Anaphase promoting complex subunit 1) (2016) (0)
- Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Mitotic checkpoint complex (APC/C-MCC) at 4.2 angstrom resolution (2016) (0)
- Crystal structure of APC/C hetero-tetramer Cut9-Hcn1 (2011) (0)
- PTP1B with the catalytic cysteine oxidized to sulfonic acid (2003) (0)
- CRYSTAL STRUCTURE OF KINASE ASSOCIATED PHOSPHATASE (KAP) IN COMPLEX WITH PHOSPHO-CDK2 (2001) (0)
- Structure of PKB kinase domain (2003) (0)
- N-terminal domain of S. pombe Cdc23 APC subunit (2013) (0)
- The structure of a Piwi protein from Archaeoglobus fulgidus complexed with a 16nt siRNA duplex. (2005) (0)
- Cryo-EM structure of the CBF3-CEN3 complex of the budding yeast kinetochore (2018) (0)
- CryoEM structure of the human Separase-Cdk1-cyclin B1-Cks1 complex (2021) (0)
- Structure of cAMP-dependent protein kinase complexed with A-443654 (2007) (0)
- The complex of wild type B-RAF and BAY439006. (2004) (0)
- Structural basis of the anaphase promoting complex (2011) (0)
- Human ptp1b complexed with tpicooh (1999) (0)
- The complex of mutant V599E B-RAF and BAY439006. (2004) (0)
- Cyclic peptide inhibitor of human PTP1B (1999) (0)
- AKAP18 delta central domain - AMP (2008) (0)
- Structure of activated form of PKB kinase domain S474D with GSK3 peptide and AMP-PNP (2002) (0)
- Structure of inner kinetochore CCAN-Cenp-A complex (2019) (0)
- alpha-catenin M-domain (2001) (0)
- Crystal structure of the DHR2 domain of DOCK10 in complex with CDC42 (2020) (0)
- CRYSTAL STRUCTURE ANALYSIS OF KINASE ASSOCIATED PHOSPHATASE (KAP) WITH A SUBSTITUTION OF THE CATALYTIC SITE CYSTEINE (CYS140) TO A SERINE (2001) (0)
- Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D2 box class (2019) (0)
- Crystal structure of the Pp2A phosphatase activator Ypa1 PTPA1 in complex with model substrate (2006) (0)
- A MAD way to regulate mitosis (2018) (0)
- Cryo-EM structure of TRIP13 in complex with ATP gamma S, p31comet, C-Mad2 and Cdc20 (2018) (0)
- Table of Contents (1986) (0)
- Structure of PKA-PKB chimera complexed with ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY) ETHYLAMINO)ETHYL)AMIDE (2007) (0)
- Structure of the human APC-Cdc20-Hsl1 complex (2016) (0)
- Orthorhombic P212121 Structure of Human Mad1 C-terminal Domain in Complex with Phosphorylated Bub1 CD1 Domain (2021) (0)
- Structure of the human APC-Cdh1-Hsl1-UbcH10 complex. (2015) (0)
- CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH A BIS-PHOSPHORYLATED PEPTIDE (ETD(PTR)(PTR)RKGGKGLL) FROM THE INSULIN RECEPTOR KINASE (2001) (0)
- The Structure of the Cyld Usp Domain Explains its Specificity for Lys63-Linked Polyubiquitin and Reveals a B-Box Module (2008) (0)
- The structure of protein tyrosine phosphatase-1B complexed to a high affinity inhibitor (1996) (0)
- Solid state 3'P cross-polarization/magic angle sample spinning nuclear magnetic resonance studies of crystalline glycogen phosphorylase b (2005) (0)
- Crystal Structure of Ma-ICMT (2012) (0)
- STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH 4-(4-chloro-phenyl)-4-(4-(1H-pyrazol-4-yl)-phenyl)-piperidine (2007) (0)
- Crystal structure of 26S proteasome subunit Rpn2 (2012) (0)
- crystal structure of linear di-ubiquitin (2009) (0)
- Human protein-tyrosine phosphatase 1b C215A, S216A mutant (2011) (0)
- The Structure of a Piwi protein from Archaeoglobus fulgidus. (2005) (0)
- Structure of human PTPA (2006) (0)
- Structure of PKA-PKB chimera complexed with 2-(4-(5-methyl-1H-pyrazol- 4-yl)-phenyl)-ethylamine (2007) (0)
- CRYSTAL STRUCTURE OF CONSTANT REGULATORY DOMAIN OF HUMAN PP2A, PR65ALPHA (1999) (0)
- Structure of PKA-PKB chimera complexed with 5-methyl-4-phenyl-1H- pyrazole (2007) (0)
- Monoclinic P21 Structure of Human Mad1 C-terminal Domain in Complex with Phosphorylated Bub1 CD1 Domain (2021) (0)
- Structure of PKA-PKB chimera complexed with (R)-2-(4-chloro-phenyl)- 2-(4-1H-pyrazol-4-yl)-phenyl)-ethylamine (2007) (0)
- Structure of PKA-PKB chimera complexed with 2-(4-chloro-phenyl)-2- phenyl-ethylamine (2007) (0)
- Cdc27 N-terminus (2010) (0)
- Mitotic spindle assembly is controlled by the APC/C localized at the centrosome (2020) (0)
- Table of Contents (1996) (0)
- STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH THE INHIBITOR A-443654 (2007) (0)
- Cryo-EM structure of a Separase-Securin complex from Caenorhabditis elegans at 3.8 A resolution (2017) (0)
- CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH A TRI-PHOSPHORYLATED PEPTIDE (RDI(PTR)ETD(PTR)(PTR)RK) FROM THE INSULIN RECEPTOR KINASE (2001) (0)
- Crystal Structure of Mitotic Checkpoint Complex (2012) (0)
- CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH PHOSPHOTYROSINE-CONTAINING TETRA-PEPTIDE (AC-DEPYL-NH2) (1996) (0)
- Editorial overview: Macromolecular machines and assemblies. (2016) (0)
- Insights into mRNA recognition from a PIWI-siRNA complex (2005) (0)
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